1DRBA

Crystal structure of unliganded escherichia coli dihydrofolate reductase. ligand-induced conformational changes and cooperativity in binding
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPACLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 44
structure length 159
sequence length 159
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1991-11-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1drbA00
4KAKA 3DGAA 4G8ZX 3SQYX 1JOLA 4DPHA 3S3VA 4X5GA 3LG4A 4M2XA 3N0HA 3K45A 2ANQA 4TU5X 1TDRA 3CLBA 4H95A 1DG5A 3L3RA 4QI9A 3INVA 3SAIA 4XT8A 4RGCA 4P3QA 3NZCX 4X5FA 2ANOA 2QK8A 4QJCA 3SRSX 5EAJA 1S3UA 3FL9A 1JUVA 2B3ZA 3S7AA 3UM8A 1IA1A 1DRBA 4EIGA 2W3WA 4Q0DA 4ELGA 5U26A 3NZ6X 4XECX 3EEKA 1DG7A 5DXVA 1IA4A 3UM6A 3SA2A 1DG8A 1DIUA 4EJ1A 4Q6AA 1S3YA 3JW5A 1RX8A 2W9HA 2L28A 2LF1A 1SEJA 2HM9A 1DRFA 1DISA 3HBBA 1DYHA 4P68A 3FRBX 4IXED 2BLAA 1RA9A 3F0XX 3EEMA 1RE7A 3FREX 3CSEA 1RC4A 4I13A 3IRNA 3CD2A 3JWKA 1RX6A 4HOFA 3F0SX 5E8QA 3I8AX 5JG0X 3M09A 3JSUA 3SGYA 4X5IA 3RO9A 5HI6A 3FS6A 4KFJA 4ELFA 3TQBA 5HVEA 4KY4A 1HFRA 1KMVA 3QLZA 4XT5A 3DFRA 3GI2A 4QLGA 5CCCA 1DHIA 3IA5A 4LEKX 8DFRA 4H98A 7DFRA 3TD8A 2GD9A 3QL3A 1DR1A 4M6KA 3E0BA 1IA2A 3NZBX 4M6JA 3SRRX 1DR3A 1DHFA 1VJ3A 3SRQX 4XT6A 4ELEA 1HFPA 1VDRA 4X5HA 1HFQA 2CIGA 2FZJA 4PDJA 3QLRA 3F0BX 3IA4A 4KM2A 4CD2A 4FHBA 3F0QX 2CD2A 2W3MA 1RX5A 3I3RA 4X5JA 1LUDA 4KYAA 1RG7A 2OIPA 3FQFA 3EELA 2JYBA 3FL8A 1DR6A 4XE6X 3FQCA 2FZIA 3QGTA 1OHKA 3KJSA 3UM5A 4OR7A 4ELHA 1RF7A 4GH8A 4DP3A 3FYVX 3NRRA 3JVXA 4IXGX 4M6LA 2W3BA 3JWFA 2O7PA 5HSRA 5HF2X 5U27A 6DFRA 1J3JA 3FRFX 4PTHA 2FZHA 3F8YA 3FRAX 3D80A 3JWCA 5HT5A 3EIGA 1LY3A 3FQ0A 3FY9X 1AOEA 1DRAA 4HOGA 1RH3A 4PSYA 4Q0EA 1BZFA 5HSUA 4Q67A 4QLEA 4KJJA 4DFRA 2BLBA 3ROAA 3F91A 4KJLA 4KEBA 3NXOA 3SR5X 1U71A 1ZDRA 1DYIA 3FRDX 1KMSA 2BLCA 1IA3A 3VCOA 1JOMA 4XT4A 3EX8A 4OSGA 4PSSA 3NTZA 3OAFA 4LAEX 4QJZD 3FQVA 4ECKA 1CD2A 3NZ9X 1RX1A 3KY8A 1RA2A 1AO8A 3NXXA 1MVSA 2HXVA 2OBCA 1DAJA 3DAUA 4HA7A 3D84X 4KNEA 2W3VA 1YHOA 3M08A 1U72A 3GHVA 1M79A 3FQOA 3ZPGA 3NXVA 1RX7A 3QYLA 4KM0A 4KBNA 3EEJA 4FGHA 2C2SA 2DRCA 4P3RA 4HA9A 5ECXA 2INQA 1DYJA 3K2HA 1DHJA 4KY8A 3SH2A 3FY8X 5HT4A 4G95A 4ELBA 4LAGX 1RX2A 1BOZA 1OHJA 3TQ8A 3GHCA 1U70A 3FQZA 3QLWA 4XRBA 1RA8A 4IXFX 3K74A 2ZZAA 3KJRA 5HVBA 5DFRA 1DR4A 4P66A 2AZNA 3JW3A 3TQ9A 3QG2A 3QL0A 4QLFA 4LAHX 3DL5A 1CZ3A 1RA1A 4DPDA 1J3IA 4PTJA 3NZDA 3SRUX 1DREA 5FDAA 3IX9A 1D1GA 1M7AA 5ECCA 5CC9A 4EIZA 1MVTA 2P4GA 3OCHA 1RX4A 4KJKA 4HOEA 2C2TA 2KGKA 3TQAA 4FGGA 1DYRA 4M7UA 3NXRA 1AI9A 2D5NA 2H2QA 4PSTA 5HF0X 4KLXA 1DRHA 3RG9A 3QFXA 3SRWX 4G3MA 1DDRA 1DF7A 3NXTA 5HPBA 4NX6A 1RB2A 4KD7A 1DR7A 1RA3A 1PDBA 2W9TA 1KLKA 3DATA 3IROA 3QLSA 3CL9A 3KFYA 1DR2A 2XW7A 3S9UA 3JWMA 1DR5A 2DHFA 2BL9A 4KL9A 1PD9A 1S3WA 1DDSA 4M7VA 1DLRA 2ITHA 4EILA 1RX9A 3K47A 5JA3A 3R33A 2HQPA 3DL6A 3GYFA 4NX7A 5HQZA 1J3KA 1DLSA 3QLXA 3FYWX 2W9SA 3Q1HA 1QZFA 3DG8A 4XT7A 1RB3A 5HQYA 1M78A 3NU0A 5HUIA 3HJ3A 3NZAX 3KGYA 4DDRA 3F8ZA 1E26A 3ZPCA 4H97A 3SA1A 1RX3A 3QYOA 2W3AA 3IRMA 1LY4A 2G6VA 3F0VX 1PD8A 1RD7A 3DRCA 3GHWA 2W9GA 3JTWA 2D0KA 4H96A 3F0UX 1S3VA 3QLYA 4QHVA 3NXYA 4I1NA
chains in the Genus database with same CATH superfamily
4KAKA 3DGAA 4G8ZX 3SQYX 1JOLA 4DPHA 3S3VA 4X5GA 3LG4A 4M2XA 3N0HA 3K45A 2ANQA 4TU5X 1TDRA 3CLBA 4H95A 1DG5A 3L3RA 4QI9A 3INVA 3SAIA 4XT8A 4RGCA 4P3QA 3NZCX 4X5FA 2ANOA 2QK8A 4QJCA 3SRSX 5EAJA 1S3UA 3FL9A 1JUVA 2B3ZA 3S7AA 3UM8A 1IA1A 1DRBA 4EIGA 2W3WA 4Q0DA 4ELGA 5U26A 3NZ6X 4XECX 3EEKA 1DG7A 5DXVA 1IA4A 3UM6A 3SA2A 1DG8A 1DIUA 4EJ1A 4Q6AA 1S3YA 3JW5A 1RX8A 2W9HA 2L28A 2LF1A 1SEJA 2HM9A 1DRFA 1DISA 3HBBA 1DYHA 4P68A 3FRBX 4IXED 2BLAA 1RA9A 3F0XX 3EEMA 1RE7A 3FREX 3CSEA 1RC4A 4I13A 3IRNA 3CD2A 3JWKA 1RX6A 4HOFA 3F0SX 5E8QA 3I8AX 5JG0X 3M09A 3JSUA 3SGYA 4X5IA 3RO9A 5HI6A 3FS6A 4KFJA 4ELFA 3TQBA 5HVEA 4KY4A 1HFRA 1KMVA 3QLZA 4XT5A 3DFRA 3GI2A 4QLGA 5CCCA 1DHIA 3IA5A 4LEKX 8DFRA 4H98A 7DFRA 3TD8A 2GD9A 3QL3A 1DR1A 4M6KA 3E0BA 1IA2A 3NZBX 4M6JA 3SRRX 1DR3A 1DHFA 1VJ3A 3SRQX 4XT6A 4ELEA 1HFPA 1VDRA 4X5HA 1HFQA 2CIGA 2FZJA 4PDJA 3QLRA 3F0BX 3IA4A 4KM2A 4CD2A 4FHBA 3F0QX 2CD2A 2W3MA 1RX5A 3I3RA 4X5JA 1LUDA 4KYAA 1RG7A 2OIPA 3FQFA 3EELA 2JYBA 3FL8A 1DR6A 4XE6X 3FQCA 2FZIA 3QGTA 1OHKA 3KJSA 3UM5A 4OR7A 4ELHA 1RF7A 4GH8A 4DP3A 3FYVX 3NRRA 3JVXA 4IXGX 4M6LA 2W3BA 3JWFA 2O7PA 5HSRA 5HF2X 5U27A 6DFRA 1J3JA 3FRFX 4PTHA 2FZHA 3F8YA 3FRAX 3D80A 3JWCA 5HT5A 3EIGA 1LY3A 3FQ0A 3FY9X 1AOEA 1DRAA 4HOGA 1RH3A 4PSYA 4Q0EA 1BZFA 5HSUA 4Q67A 4QLEA 4KJJA 4DFRA 2BLBA 3ROAA 3F91A 4KJLA 4KEBA 3NXOA 3SR5X 1U71A 1ZDRA 1DYIA 3FRDX 1KMSA 2BLCA 1IA3A 3VCOA 1JOMA 4XT4A 3EX8A 4OSGA 4PSSA 3NTZA 3OAFA 4LAEX 4QJZD 3FQVA 4ECKA 1CD2A 3NZ9X 1RX1A 3KY8A 1RA2A 1AO8A 3NXXA 1MVSA 2HXVA 2OBCA 1DAJA 3DAUA 4HA7A 3D84X 4KNEA 2W3VA 1YHOA 3M08A 1U72A 3GHVA 1M79A 3FQOA 3ZPGA 3NXVA 1RX7A 3QYLA 4KM0A 4KBNA 3EEJA 4FGHA 2C2SA 2DRCA 4P3RA 4HA9A 5ECXA 2INQA 1DYJA 3K2HA 1DHJA 4KY8A 3SH2A 3FY8X 5HT4A 4G95A 4ELBA 4LAGX 1RX2A 1BOZA 1OHJA 3TQ8A 3GHCA 1U70A 3FQZA 3QLWA 4XRBA 1RA8A 4IXFX 3K74A 2ZZAA 3KJRA 5HVBA 5DFRA 1DR4A 4P66A 2AZNA 3JW3A 3TQ9A 3QG2A 3QL0A 4QLFA 4LAHX 3DL5A 1CZ3A 1RA1A 4DPDA 1J3IA 4PTJA 3NZDA 3SRUX 1DREA 5FDAA 3IX9A 1D1GA 1M7AA 5ECCA 5CC9A 4EIZA 1MVTA 2P4GA 3OCHA 1RX4A 4KJKA 4HOEA 2C2TA 2KGKA 3TQAA 4FGGA 1DYRA 4M7UA 3NXRA 1AI9A 2D5NA 2H2QA 4PSTA 5HF0X 4KLXA 1DRHA 3RG9A 3QFXA 3SRWX 4G3MA 1DDRA 1DF7A 3NXTA 5HPBA 4NX6A 1RB2A 4KD7A 1DR7A 1RA3A 1PDBA 2W9TA 1KLKA 3DATA 3IROA 3QLSA 3CL9A 3KFYA 1DR2A 2XW7A 3S9UA 3JWMA 1DR5A 2DHFA 2BL9A 4KL9A 1PD9A 1S3WA 1DDSA 4M7VA 1DLRA 2ITHA 4EILA 1RX9A 3K47A 5JA3A 3R33A 2HQPA 3DL6A 3GYFA 4NX7A 5HQZA 1J3KA 1DLSA 3QLXA 3FYWX 2W9SA 3Q1HA 1QZFA 3DG8A 4XT7A 1RB3A 5HQYA 1M78A 3NU0A 5HUIA 3HJ3A 3NZAX 3KGYA 4DDRA 3F8ZA 1E26A 3ZPCA 4H97A 3SA1A 1RX3A 3QYOA 2W3AA 3IRMA 1LY4A 2G6VA 3F0VX 1PD8A 1RD7A 3DRCA 3GHWA 2W9GA 3JTWA 2D0KA 4H96A 3F0UX 1S3VA 3QLYA 4QHVA 3NXYA 4I1NA
chains in the Genus database with same CATH topology
4KAKA 3DGAA 4G8ZX 3SQYX 1JOLA 4DPHA 3S3VA 4X5GA 3LG4A 4M2XA 3N0HA 3K45A 2ANQA 4TU5X 1TDRA 3CLBA 4H95A 1DG5A 3L3RA 4QI9A 3INVA 3SAIA 4XT8A 4RGCA 4P3QA 3NZCX 4X5FA 2ANOA 2QK8A 4QJCA 3SRSX 5EAJA 1S3UA 3FL9A 1JUVA 2B3ZA 3S7AA 3UM8A 1IA1A 1DRBA 4EIGA 2W3WA 4Q0DA 4ELGA 5U26A 3NZ6X 4XECX 3EEKA 1DG7A 5DXVA 1IA4A 3UM6A 3SA2A 1DG8A 1DIUA 4EJ1A 4Q6AA 1S3YA 3JW5A 1RX8A 2W9HA 2L28A 2LF1A 1SEJA 2HM9A 1DRFA 1DISA 3HBBA 1DYHA 4P68A 3FRBX 4IXED 2BLAA 1RA9A 3F0XX 3EEMA 1RE7A 3FREX 3CSEA 1RC4A 4I13A 3IRNA 3CD2A 3JWKA 1RX6A 4HOFA 3F0SX 5E8QA 3I8AX 5JG0X 3M09A 3JSUA 3SGYA 4X5IA 3RO9A 5HI6A 3FS6A 4KFJA 4ELFA 3TQBA 5HVEA 4KY4A 1HFRA 1KMVA 3QLZA 4XT5A 3DFRA 3GI2A 4QLGA 5CCCA 1DHIA 3IA5A 4LEKX 8DFRA 4H98A 7DFRA 3TD8A 2GD9A 3QL3A 1DR1A 4M6KA 3E0BA 1IA2A 3NZBX 4M6JA 3SRRX 1DR3A 1DHFA 1VJ3A 3SRQX 4XT6A 4ELEA 1HFPA 1VDRA 4X5HA 1HFQA 2CIGA 2FZJA 4PDJA 3QLRA 3F0BX 3IA4A 4KM2A 4CD2A 4FHBA 3F0QX 2CD2A 2W3MA 1RX5A 3I3RA 4X5JA 1LUDA 4KYAA 1RG7A 2OIPA 3FQFA 3EELA 2JYBA 3FL8A 1DR6A 4XE6X 3FQCA 2FZIA 3QGTA 1OHKA 3KJSA 3UM5A 4OR7A 4ELHA 1RF7A 4GH8A 4DP3A 3FYVX 3NRRA 3JVXA 4IXGX 4M6LA 2W3BA 3JWFA 2O7PA 5HSRA 5HF2X 5U27A 6DFRA 1J3JA 3FRFX 4PTHA 2FZHA 3F8YA 3FRAX 3D80A 3JWCA 5HT5A 3EIGA 1LY3A 3FQ0A 3FY9X 1AOEA 1DRAA 4HOGA 1RH3A 4PSYA 4Q0EA 1BZFA 5HSUA 4Q67A 4QLEA 4KJJA 4DFRA 2BLBA 3ROAA 3F91A 4KJLA 4KEBA 3NXOA 3SR5X 1U71A 1ZDRA 1DYIA 3FRDX 1KMSA 2BLCA 1IA3A 3VCOA 1JOMA 4XT4A 3EX8A 4OSGA 4PSSA 3NTZA 3OAFA 4LAEX 4QJZD 3FQVA 4ECKA 1CD2A 3NZ9X 1RX1A 3KY8A 1RA2A 1AO8A 3NXXA 1MVSA 2HXVA 2OBCA 1DAJA 3DAUA 4HA7A 3D84X 4KNEA 2W3VA 1YHOA 3M08A 1U72A 3GHVA 1M79A 3FQOA 3ZPGA 3NXVA 1RX7A 3QYLA 4KM0A 4KBNA 3EEJA 4FGHA 2C2SA 2DRCA 4P3RA 4HA9A 5ECXA 2INQA 1DYJA 3K2HA 1DHJA 4KY8A 3SH2A 3FY8X 5HT4A 4G95A 4ELBA 4LAGX 1RX2A 1BOZA 1OHJA 3TQ8A 3GHCA 1U70A 3FQZA 3QLWA 4XRBA 1RA8A 4IXFX 3K74A 2ZZAA 3KJRA 5HVBA 5DFRA 1DR4A 4P66A 2AZNA 3JW3A 3TQ9A 3QG2A 3QL0A 4QLFA 4LAHX 3DL5A 1CZ3A 1RA1A 4DPDA 1J3IA 4PTJA 3NZDA 3SRUX 1DREA 5FDAA 3IX9A 1D1GA 1M7AA 5ECCA 5CC9A 4EIZA 1MVTA 2P4GA 3OCHA 1RX4A 4KJKA 4HOEA 2C2TA 2KGKA 3TQAA 4FGGA 1DYRA 4M7UA 3NXRA 1AI9A 2D5NA 2H2QA 4PSTA 5HF0X 4KLXA 1DRHA 3RG9A 3QFXA 3SRWX 4G3MA 1DDRA 1DF7A 3NXTA 5HPBA 4NX6A 1RB2A 4KD7A 1DR7A 1RA3A 1PDBA 2W9TA 1KLKA 3DATA 3IROA 3QLSA 3CL9A 3KFYA 1DR2A 2XW7A 3S9UA 3JWMA 1DR5A 2DHFA 2BL9A 4KL9A 1PD9A 1S3WA 1DDSA 4M7VA 1DLRA 2ITHA 4EILA 1RX9A 3K47A 5JA3A 3R33A 2HQPA 3DL6A 3GYFA 4NX7A 5HQZA 1J3KA 1DLSA 3QLXA 3FYWX 2W9SA 3Q1HA 1QZFA 3DG8A 4XT7A 1RB3A 5HQYA 1M78A 3NU0A 5HUIA 3HJ3A 3NZAX 3KGYA 4DDRA 3F8ZA 1E26A 3ZPCA 4H97A 3SA1A 1RX3A 3QYOA 2W3AA 3IRMA 1LY4A 2G6VA 3F0VX 1PD8A 1RD7A 3DRCA 3GHWA 2W9GA 3JTWA 2D0KA 4H96A 3F0UX 1S3VA 3QLYA 4QHVA 3NXYA 4I1NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KAK A;  3DGA A;  4G8Z X;  3SQY X;  1JOL A;  4DPH A;  3S3V A;  4X5G A;  3LG4 A;  4M2X A;  3N0H A;  3K45 A;  2ANQ A;  4TU5 X;  1TDR A;  3CLB A;  4H95 A;  1DG5 A;  3L3R A;  4QI9 A;  3INV A;  3SAI A;  4XT8 A;  4RGC A;  4P3Q A;  3NZC X;  4X5F A;  2ANO A;  2QK8 A;  4QJC A;  3SRS X;  5EAJ A;  1S3U A;  3FL9 A;  1JUV A;  2B3Z A;  3S7A A;  3UM8 A;  1IA1 A;  1DRB A;  4EIG A;  2W3W A;  4Q0D A;  4ELG A;  5U26 A;  3NZ6 X;  4XEC X;  3EEK A;  1DG7 A;  5DXV A;  1IA4 A;  3UM6 A;  3SA2 A;  1DG8 A;  1DIU A;  4EJ1 A;  4Q6A A;  1S3Y A;  3JW5 A;  1RX8 A;  2W9H A;  2L28 A;  2LF1 A;  1SEJ A;  2HM9 A;  1DRF A;  1DIS A;  3HBB A;  1DYH A;  4P68 A;  3FRB X;  4IXE D;  2BLA A;  1RA9 A;  3F0X X;  3EEM A;  1RE7 A;  3FRE X;  3CSE A;  1RC4 A;  4I13 A;  3IRN A;  3CD2 A;  3JWK A;  1RX6 A;  4HOF A;  3F0S X;  5E8Q A;  3I8A X;  5JG0 X;  3M09 A;  3JSU A;  3SGY A;  4X5I A;  3RO9 A;  5HI6 A;  3FS6 A;  4KFJ A;  4ELF A;  3TQB A;  5HVE A;  4KY4 A;  1HFR A;  1KMV A;  3QLZ A;  4XT5 A;  3DFR A;  3GI2 A;  4QLG A;  5CCC A;  1DHI A;  3IA5 A;  4LEK X;  8DFR A;  4H98 A;  7DFR A;  3TD8 A;  2GD9 A;  3QL3 A;  1DR1 A;  4M6K A;  3E0B A;  1IA2 A;  3NZB X;  4M6J A;  3SRR X;  1DR3 A;  1DHF A;  1VJ3 A;  3SRQ X;  4XT6 A;  4ELE A;  1HFP A;  1VDR A;  4X5H A;  1HFQ A;  2CIG A;  2FZJ A;  4PDJ A;  3QLR A;  3F0B X;  3IA4 A;  4KM2 A;  4CD2 A;  4FHB A;  3F0Q X;  2CD2 A;  2W3M A;  1RX5 A;  3I3R A;  4X5J A;  1LUD A;  4KYA A;  1RG7 A;  2OIP A;  3FQF A;  3EEL A;  2JYB A;  3FL8 A;  1DR6 A;  4XE6 X;  3FQC A;  2FZI A;  3QGT A;  1OHK A;  3KJS A;  3UM5 A;  4OR7 A;  4ELH A;  1RF7 A;  4GH8 A;  4DP3 A;  3FYV X;  3NRR A;  3JVX A;  4IXG X;  4M6L A;  2W3B A;  3JWF A;  2O7P A;  5HSR A;  5HF2 X;  5U27 A;  6DFR A;  1J3J A;  3FRF X;  4PTH A;  2FZH A;  3F8Y A;  3FRA X;  3D80 A;  3JWC A;  5HT5 A;  3EIG A;  1LY3 A;  3FQ0 A;  3FY9 X;  1AOE A;  1DRA A;  4HOG A;  1RH3 A;  4PSY A;  4Q0E A;  1BZF A;  5HSU A;  4Q67 A;  4QLE A;  4KJJ A;  4DFR A;  2BLB A;  3ROA A;  3F91 A;  4KJL A;  4KEB A;  3NXO A;  3SR5 X;  1U71 A;  1ZDR A;  1DYI A;  3FRD X;  1KMS A;  2BLC A;  1IA3 A;  3VCO A;  1JOM A;  4XT4 A;  3EX8 A;  4OSG A;  4PSS A;  3NTZ A;  3OAF A;  4LAE X;  4QJZ D;  3FQV A;  4ECK A;  1CD2 A;  3NZ9 X;  1RX1 A;  3KY8 A;  1RA2 A;  1AO8 A;  3NXX A;  1MVS A;  2HXV A;  2OBC A;  1DAJ A;  3DAU A;  4HA7 A;  3D84 X;  4KNE A;  2W3V A;  1YHO A;  3M08 A;  1U72 A;  3GHV A;  1M79 A;  3FQO A;  3ZPG A;  3NXV A;  1RX7 A;  3QYL A;  4KM0 A;  4KBN A;  3EEJ A;  4FGH A;  2C2S A;  2DRC A;  4P3R A;  4HA9 A;  5ECX A;  2INQ A;  1DYJ A;  3K2H A;  1DHJ A;  4KY8 A;  3SH2 A;  3FY8 X;  5HT4 A;  4G95 A;  4ELB A;  4LAG X;  1RX2 A;  1BOZ A;  1OHJ A;  3TQ8 A;  3GHC A;  1U70 A;  3FQZ A;  3QLW A;  4XRB A;  1RA8 A;  4IXF X;  3K74 A;  2ZZA A;  3KJR A;  5HVB A;  5DFR A;  1DR4 A;  4P66 A;  2AZN A;  3JW3 A;  3TQ9 A;  3QG2 A;  3QL0 A;  4QLF A;  4LAH X;  3DL5 A;  1CZ3 A;  1RA1 A;  4DPD A;  1J3I A;  4PTJ A;  3NZD A;  3SRU X;  1DRE A;  5FDA A;  3IX9 A;  1D1G A;  1M7A A;  5ECC A;  5CC9 A;  4EIZ A;  1MVT A;  2P4G A;  3OCH A;  1RX4 A;  4KJK A;  4HOE A;  2C2T A;  2KGK A;  3TQA A;  4FGG A;  1DYR A;  4M7U A;  3NXR A;  1AI9 A;  2D5N A;  2H2Q A;  4PST A;  5HF0 X;  4KLX A;  1DRH A;  3RG9 A;  3QFX A;  3SRW X;  4G3M A;  1DDR A;  1DF7 A;  3NXT A;  5HPB A;  4NX6 A;  1RB2 A;  4KD7 A;  1DR7 A;  1RA3 A;  1PDB A;  2W9T A;  1KLK A;  3DAT A;  3IRO A;  3QLS A;  3CL9 A;  3KFY A;  1DR2 A;  2XW7 A;  3S9U A;  3JWM A;  1DR5 A;  2DHF A;  2BL9 A;  4KL9 A;  1PD9 A;  1S3W A;  1DDS A;  4M7V A;  1DLR A;  2ITH A;  4EIL A;  1RX9 A;  3K47 A;  5JA3 A;  3R33 A;  2HQP A;  3DL6 A;  3GYF A;  4NX7 A;  5HQZ A;  1J3K A;  1DLS A;  3QLX A;  3FYW X;  2W9S A;  3Q1H A;  1QZF A;  3DG8 A;  4XT7 A;  1RB3 A;  5HQY A;  1M78 A;  3NU0 A;  5HUI A;  3HJ3 A;  3NZA X;  3KGY A;  4DDR A;  3F8Z A;  1E26 A;  3ZPC A;  4H97 A;  3SA1 A;  1RX3 A;  3QYO A;  2W3A A;  3IRM A;  1LY4 A;  2G6V A;  3F0V X;  1PD8 A;  1RD7 A;  3DRC A;  3GHW A;  2W9G A;  3JTW A;  2D0K A;  4H96 A;  3F0U X;  1S3V A;  3QLY A;  4QHV A;  3NXY A;  4I1N A; 
#chains in the Genus database with same CATH topology
 4KAK A;  3DGA A;  4G8Z X;  3SQY X;  1JOL A;  4DPH A;  3S3V A;  4X5G A;  3LG4 A;  4M2X A;  3N0H A;  3K45 A;  2ANQ A;  4TU5 X;  1TDR A;  3CLB A;  4H95 A;  1DG5 A;  3L3R A;  4QI9 A;  3INV A;  3SAI A;  4XT8 A;  4RGC A;  4P3Q A;  3NZC X;  4X5F A;  2ANO A;  2QK8 A;  4QJC A;  3SRS X;  5EAJ A;  1S3U A;  3FL9 A;  1JUV A;  2B3Z A;  3S7A A;  3UM8 A;  1IA1 A;  1DRB A;  4EIG A;  2W3W A;  4Q0D A;  4ELG A;  5U26 A;  3NZ6 X;  4XEC X;  3EEK A;  1DG7 A;  5DXV A;  1IA4 A;  3UM6 A;  3SA2 A;  1DG8 A;  1DIU A;  4EJ1 A;  4Q6A A;  1S3Y A;  3JW5 A;  1RX8 A;  2W9H A;  2L28 A;  2LF1 A;  1SEJ A;  2HM9 A;  1DRF A;  1DIS A;  3HBB A;  1DYH A;  4P68 A;  3FRB X;  4IXE D;  2BLA A;  1RA9 A;  3F0X X;  3EEM A;  1RE7 A;  3FRE X;  3CSE A;  1RC4 A;  4I13 A;  3IRN A;  3CD2 A;  3JWK A;  1RX6 A;  4HOF A;  3F0S X;  5E8Q A;  3I8A X;  5JG0 X;  3M09 A;  3JSU A;  3SGY A;  4X5I A;  3RO9 A;  5HI6 A;  3FS6 A;  4KFJ A;  4ELF A;  3TQB A;  5HVE A;  4KY4 A;  1HFR A;  1KMV A;  3QLZ A;  4XT5 A;  3DFR A;  3GI2 A;  4QLG A;  5CCC A;  1DHI A;  3IA5 A;  4LEK X;  8DFR A;  4H98 A;  7DFR A;  3TD8 A;  2GD9 A;  3QL3 A;  1DR1 A;  4M6K A;  3E0B A;  1IA2 A;  3NZB X;  4M6J A;  3SRR X;  1DR3 A;  1DHF A;  1VJ3 A;  3SRQ X;  4XT6 A;  4ELE A;  1HFP A;  1VDR A;  4X5H A;  1HFQ A;  2CIG A;  2FZJ A;  4PDJ A;  3QLR A;  3F0B X;  3IA4 A;  4KM2 A;  4CD2 A;  4FHB A;  3F0Q X;  2CD2 A;  2W3M A;  1RX5 A;  3I3R A;  4X5J A;  1LUD A;  4KYA A;  1RG7 A;  2OIP A;  3FQF A;  3EEL A;  2JYB A;  3FL8 A;  1DR6 A;  4XE6 X;  3FQC A;  2FZI A;  3QGT A;  1OHK A;  3KJS A;  3UM5 A;  4OR7 A;  4ELH A;  1RF7 A;  4GH8 A;  4DP3 A;  3FYV X;  3NRR A;  3JVX A;  4IXG X;  4M6L A;  2W3B A;  3JWF A;  2O7P A;  5HSR A;  5HF2 X;  5U27 A;  6DFR A;  1J3J A;  3FRF X;  4PTH A;  2FZH A;  3F8Y A;  3FRA X;  3D80 A;  3JWC A;  5HT5 A;  3EIG A;  1LY3 A;  3FQ0 A;  3FY9 X;  1AOE A;  1DRA A;  4HOG A;  1RH3 A;  4PSY A;  4Q0E A;  1BZF A;  5HSU A;  4Q67 A;  4QLE A;  4KJJ A;  4DFR A;  2BLB A;  3ROA A;  3F91 A;  4KJL A;  4KEB A;  3NXO A;  3SR5 X;  1U71 A;  1ZDR A;  1DYI A;  3FRD X;  1KMS A;  2BLC A;  1IA3 A;  3VCO A;  1JOM A;  4XT4 A;  3EX8 A;  4OSG A;  4PSS A;  3NTZ A;  3OAF A;  4LAE X;  4QJZ D;  3FQV A;  4ECK A;  1CD2 A;  3NZ9 X;  1RX1 A;  3KY8 A;  1RA2 A;  1AO8 A;  3NXX A;  1MVS A;  2HXV A;  2OBC A;  1DAJ A;  3DAU A;  4HA7 A;  3D84 X;  4KNE A;  2W3V A;  1YHO A;  3M08 A;  1U72 A;  3GHV A;  1M79 A;  3FQO A;  3ZPG A;  3NXV A;  1RX7 A;  3QYL A;  4KM0 A;  4KBN A;  3EEJ A;  4FGH A;  2C2S A;  2DRC A;  4P3R A;  4HA9 A;  5ECX A;  2INQ A;  1DYJ A;  3K2H A;  1DHJ A;  4KY8 A;  3SH2 A;  3FY8 X;  5HT4 A;  4G95 A;  4ELB A;  4LAG X;  1RX2 A;  1BOZ A;  1OHJ A;  3TQ8 A;  3GHC A;  1U70 A;  3FQZ A;  3QLW A;  4XRB A;  1RA8 A;  4IXF X;  3K74 A;  2ZZA A;  3KJR A;  5HVB A;  5DFR A;  1DR4 A;  4P66 A;  2AZN A;  3JW3 A;  3TQ9 A;  3QG2 A;  3QL0 A;  4QLF A;  4LAH X;  3DL5 A;  1CZ3 A;  1RA1 A;  4DPD A;  1J3I A;  4PTJ A;  3NZD A;  3SRU X;  1DRE A;  5FDA A;  3IX9 A;  1D1G A;  1M7A A;  5ECC A;  5CC9 A;  4EIZ A;  1MVT A;  2P4G A;  3OCH A;  1RX4 A;  4KJK A;  4HOE A;  2C2T A;  2KGK A;  3TQA A;  4FGG A;  1DYR A;  4M7U A;  3NXR A;  1AI9 A;  2D5N A;  2H2Q A;  4PST A;  5HF0 X;  4KLX A;  1DRH A;  3RG9 A;  3QFX A;  3SRW X;  4G3M A;  1DDR A;  1DF7 A;  3NXT A;  5HPB A;  4NX6 A;  1RB2 A;  4KD7 A;  1DR7 A;  1RA3 A;  1PDB A;  2W9T A;  1KLK A;  3DAT A;  3IRO A;  3QLS A;  3CL9 A;  3KFY A;  1DR2 A;  2XW7 A;  3S9U A;  3JWM A;  1DR5 A;  2DHF A;  2BL9 A;  4KL9 A;  1PD9 A;  1S3W A;  1DDS A;  4M7V A;  1DLR A;  2ITH A;  4EIL A;  1RX9 A;  3K47 A;  5JA3 A;  3R33 A;  2HQP A;  3DL6 A;  3GYF A;  4NX7 A;  5HQZ A;  1J3K A;  1DLS A;  3QLX A;  3FYW X;  2W9S A;  3Q1H A;  1QZF A;  3DG8 A;  4XT7 A;  1RB3 A;  5HQY A;  1M78 A;  3NU0 A;  5HUI A;  3HJ3 A;  3NZA X;  3KGY A;  4DDR A;  3F8Z A;  1E26 A;  3ZPC A;  4H97 A;  3SA1 A;  1RX3 A;  3QYO A;  2W3A A;  3IRM A;  1LY4 A;  2G6V A;  3F0V X;  1PD8 A;  1RD7 A;  3DRC A;  3GHW A;  2W9G A;  3JTW A;  2D0K A;  4H96 A;  3F0U X;  1S3V A;  3QLY A;  4QHV A;  3NXY A;  4I1N A; 
#chains in the Genus database with same CATH homology
 4KAK A;  3DGA A;  4G8Z X;  3SQY X;  1JOL A;  4DPH A;  3S3V A;  4X5G A;  3LG4 A;  4M2X A;  3N0H A;  3K45 A;  2ANQ A;  4TU5 X;  1TDR A;  3CLB A;  4H95 A;  1DG5 A;  3L3R A;  4QI9 A;  3INV A;  3SAI A;  4XT8 A;  4RGC A;  4P3Q A;  3NZC X;  4X5F A;  2ANO A;  2QK8 A;  4QJC A;  3SRS X;  5EAJ A;  1S3U A;  3FL9 A;  1JUV A;  2B3Z A;  3S7A A;  3UM8 A;  1IA1 A;  1DRB A;  4EIG A;  2W3W A;  4Q0D A;  4ELG A;  5U26 A;  3NZ6 X;  4XEC X;  3EEK A;  1DG7 A;  5DXV A;  1IA4 A;  3UM6 A;  3SA2 A;  1DG8 A;  1DIU A;  4EJ1 A;  4Q6A A;  1S3Y A;  3JW5 A;  1RX8 A;  2W9H A;  2L28 A;  2LF1 A;  1SEJ A;  2HM9 A;  1DRF A;  1DIS A;  3HBB A;  1DYH A;  4P68 A;  3FRB X;  4IXE D;  2BLA A;  1RA9 A;  3F0X X;  3EEM A;  1RE7 A;  3FRE X;  3CSE A;  1RC4 A;  4I13 A;  3IRN A;  3CD2 A;  3JWK A;  1RX6 A;  4HOF A;  3F0S X;  5E8Q A;  3I8A X;  5JG0 X;  3M09 A;  3JSU A;  3SGY A;  4X5I A;  3RO9 A;  5HI6 A;  3FS6 A;  4KFJ A;  4ELF A;  3TQB A;  5HVE A;  4KY4 A;  1HFR A;  1KMV A;  3QLZ A;  4XT5 A;  3DFR A;  3GI2 A;  4QLG A;  5CCC A;  1DHI A;  3IA5 A;  4LEK X;  8DFR A;  4H98 A;  7DFR A;  3TD8 A;  2GD9 A;  3QL3 A;  1DR1 A;  4M6K A;  3E0B A;  1IA2 A;  3NZB X;  4M6J A;  3SRR X;  1DR3 A;  1DHF A;  1VJ3 A;  3SRQ X;  4XT6 A;  4ELE A;  1HFP A;  1VDR A;  4X5H A;  1HFQ A;  2CIG A;  2FZJ A;  4PDJ A;  3QLR A;  3F0B X;  3IA4 A;  4KM2 A;  4CD2 A;  4FHB A;  3F0Q X;  2CD2 A;  2W3M A;  1RX5 A;  3I3R A;  4X5J A;  1LUD A;  4KYA A;  1RG7 A;  2OIP A;  3FQF A;  3EEL A;  2JYB A;  3FL8 A;  1DR6 A;  4XE6 X;  3FQC A;  2FZI A;  3QGT A;  1OHK A;  3KJS A;  3UM5 A;  4OR7 A;  4ELH A;  1RF7 A;  4GH8 A;  4DP3 A;  3FYV X;  3NRR A;  3JVX A;  4IXG X;  4M6L A;  2W3B A;  3JWF A;  2O7P A;  5HSR A;  5HF2 X;  5U27 A;  6DFR A;  1J3J A;  3FRF X;  4PTH A;  2FZH A;  3F8Y A;  3FRA X;  3D80 A;  3JWC A;  5HT5 A;  3EIG A;  1LY3 A;  3FQ0 A;  3FY9 X;  1AOE A;  1DRA A;  4HOG A;  1RH3 A;  4PSY A;  4Q0E A;  1BZF A;  5HSU A;  4Q67 A;  4QLE A;  4KJJ A;  4DFR A;  2BLB A;  3ROA A;  3F91 A;  4KJL A;  4KEB A;  3NXO A;  3SR5 X;  1U71 A;  1ZDR A;  1DYI A;  3FRD X;  1KMS A;  2BLC A;  1IA3 A;  3VCO A;  1JOM A;  4XT4 A;  3EX8 A;  4OSG A;  4PSS A;  3NTZ A;  3OAF A;  4LAE X;  4QJZ D;  3FQV A;  4ECK A;  1CD2 A;  3NZ9 X;  1RX1 A;  3KY8 A;  1RA2 A;  1AO8 A;  3NXX A;  1MVS A;  2HXV A;  2OBC A;  1DAJ A;  3DAU A;  4HA7 A;  3D84 X;  4KNE A;  2W3V A;  1YHO A;  3M08 A;  1U72 A;  3GHV A;  1M79 A;  3FQO A;  3ZPG A;  3NXV A;  1RX7 A;  3QYL A;  4KM0 A;  4KBN A;  3EEJ A;  4FGH A;  2C2S A;  2DRC A;  4P3R A;  4HA9 A;  5ECX A;  2INQ A;  1DYJ A;  3K2H A;  1DHJ A;  4KY8 A;  3SH2 A;  3FY8 X;  5HT4 A;  4G95 A;  4ELB A;  4LAG X;  1RX2 A;  1BOZ A;  1OHJ A;  3TQ8 A;  3GHC A;  1U70 A;  3FQZ A;  3QLW A;  4XRB A;  1RA8 A;  4IXF X;  3K74 A;  2ZZA A;  3KJR A;  5HVB A;  5DFR A;  1DR4 A;  4P66 A;  2AZN A;  3JW3 A;  3TQ9 A;  3QG2 A;  3QL0 A;  4QLF A;  4LAH X;  3DL5 A;  1CZ3 A;  1RA1 A;  4DPD A;  1J3I A;  4PTJ A;  3NZD A;  3SRU X;  1DRE A;  5FDA A;  3IX9 A;  1D1G A;  1M7A A;  5ECC A;  5CC9 A;  4EIZ A;  1MVT A;  2P4G A;  3OCH A;  1RX4 A;  4KJK A;  4HOE A;  2C2T A;  2KGK A;  3TQA A;  4FGG A;  1DYR A;  4M7U A;  3NXR A;  1AI9 A;  2D5N A;  2H2Q A;  4PST A;  5HF0 X;  4KLX A;  1DRH A;  3RG9 A;  3QFX A;  3SRW X;  4G3M A;  1DDR A;  1DF7 A;  3NXT A;  5HPB A;  4NX6 A;  1RB2 A;  4KD7 A;  1DR7 A;  1RA3 A;  1PDB A;  2W9T A;  1KLK A;  3DAT A;  3IRO A;  3QLS A;  3CL9 A;  3KFY A;  1DR2 A;  2XW7 A;  3S9U A;  3JWM A;  1DR5 A;  2DHF A;  2BL9 A;  4KL9 A;  1PD9 A;  1S3W A;  1DDS A;  4M7V A;  1DLR A;  2ITH A;  4EIL A;  1RX9 A;  3K47 A;  5JA3 A;  3R33 A;  2HQP A;  3DL6 A;  3GYF A;  4NX7 A;  5HQZ A;  1J3K A;  1DLS A;  3QLX A;  3FYW X;  2W9S A;  3Q1H A;  1QZF A;  3DG8 A;  4XT7 A;  1RB3 A;  5HQY A;  1M78 A;  3NU0 A;  5HUI A;  3HJ3 A;  3NZA X;  3KGY A;  4DDR A;  3F8Z A;  1E26 A;  3ZPC A;  4H97 A;  3SA1 A;  1RX3 A;  3QYO A;  2W3A A;  3IRM A;  1LY4 A;  2G6V A;  3F0V X;  1PD8 A;  1RD7 A;  3DRC A;  3GHW A;  2W9G A;  3JTW A;  2D0K A;  4H96 A;  3F0U X;  1S3V A;  3QLY A;  4QHV A;  3NXY A;  4I1N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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