3NTZA

Design, synthesis, biological evaluation and x-ray crystal structures of novel classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Dihydrofolate reductase
publication title Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 54
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3ntzA00
4QLGA 3RG9A 3DAUA 3FYVX 4DFRA 3NXRA 4KFJA 3KJSA 3JWCA 1DHJA 3NZDA 3D84X 2HXVA 1DG7A 3S3VA 2BLBA 3FY9X 3JW3A 2ITHA 3NXOA 3FQVA 4GH8A 2ANOA 3IRNA 3SA1A 1D1GA 4G8ZX 3CD2A 4X5HA 3F0QX 3DFRA 2FZHA 1DDSA 1HFRA 5CCCA 5HSRA 1RE7A 3QYOA 4QHVA 3OCHA 3UM8A 1BZFA 3JTWA 3QG2A 2OBCA 5HF0X 1DISA 3GHWA 2KGKA 4XECX 2QK8A 1DLSA 1S3UA 1RX8A 4OSGA 5HT5A 2W3BA 5HQZA 4I1NA 4HA7A 5ECXA 3IX9A 3OAFA 4QJZD 2W3VA 1DR4A 1HFPA 1RX1A 1RH3A 1LY3A 3F0BX 3FL9A 4IXFX 1PD8A 3FQFA 1KMSA 3JWKA 3SRWX 4KJLA 2W3AA 4EJ1A 4H97A 1DDRA 3FQZA 5HSUA 1RA2A 3E0BA 5JG0X 3TQ9A 2D0KA 2W9SA 4HOEA 4H96A 2ANQA 3NXXA 3QLWA 1M78A 2H2QA 4M6LA 3ZPGA 4LAGX 1M79A 3SRUX 1DYIA 4X5JA 2CD2A 3NXTA 1DRHA 4PSYA 2CIGA 3JWFA 1DR5A 3HBBA 3R33A 4KBNA 8DFRA 4KM0A 3FRBX 4KM2A 4DDRA 2LF1A 1RX5A 3TD8A 4KY8A 1IA1A 1RX2A 1RF7A 3FQCA 4KNEA 3UM6A 4FHBA 4HA9A 3RO9A 5HUIA 1S3VA 2GD9A 5HT4A 3IA5A 2B3ZA 4ELHA 4DP3A 3NTZA 1DR2A 4RGCA 3EEMA 7DFRA 3FRFX 3DGAA 3K74A 4LEKX 4G3MA 3QGTA 1RD7A 4PSTA 4KY4A 1DG5A 2DRCA 3M09A 3ZPCA 1RX4A 1RX7A 4EILA 1PDBA 5U27A 5CC9A 1J3KA 1CD2A 3DL6A 3K45A 4H95A 3SH2A 1YHOA 3DRCA 3EELA 5HF2X 1DHIA 1KMVA 3F0SX 1U72A 3JWMA 1SEJA 5EAJA 1JOLA 1ZDRA 2AZNA 1S3YA 3JSUA 5HVEA 4P3RA 1HFQA 5HQYA 4NX7A 3N0HA 2DHFA 3SR5X 4KYAA 3QLRA 3DG8A 3S7AA 3LG4A 4DPDA 3GHVA 1DR7A 3KJRA 3SRSX 3IROA 5JA3A 3SRQX 3NZCX 3FS6A 3QFXA 3L3RA 3NZAX 1DR6A 3F0XX 3KGYA 1CZ3A 3QLZA 1M7AA 4M6KA 1RX3A 3SRRX 4XE6X 5HI6A 1DR3A 4KD7A 4M2XA 1QZFA 4QI9A 2FZJA 4HOFA 4X5GA 3NU0A 4XT4A 2XW7A 1RA9A 5DXVA 3EEJA 3TQ8A 4XT8A 3INVA 1DG8A 2G6VA 1RB2A 2ZZAA 3I8AX 3QYLA 1PD9A 1RA1A 5FDAA 1IA2A 4Q6AA 1AOEA 1RB3A 2O7PA 5HVBA 3NZ6X 2P4GA 3VCOA 4PTHA 3ROAA 3QL0A 1DAJA 3CSEA 4Q0EA 1DRFA 3SGYA 3QLXA 4QLEA 3K47A 4X5FA 4H98A 4LAEX 2W9HA 3F0VX 4QJCA 1U71A 1VJ3A 2W9GA 2JYBA 3I3RA 1DLRA 4OR7A 4KLXA 4M6JA 4KAKA 1TDRA 4LAHX 4M7UA 2D5NA 4CD2A 1DYJA 3NZBX 3HJ3A 3CLBA 4G95A 3IA4A 1RX9A 3EIGA 3EEKA 1DRAA 4PTJA 1J3JA 5HPBA 4FGHA 3IRMA 3F8ZA 3UM5A 4XRBA 4Q0DA 2BL9A 3F8YA 2C2TA 3GI2A 3SA2A 1LY4A 4TU5X 4QLFA 5E8QA 4XT7A 4PDJA 2L28A 1DYHA 3FREX 3DL5A 3EX8A 3FQ0A 1LUDA 3GYFA 5DFRA 1DHFA 1DREA 4ELEA 4P3QA 1DF7A 2BLCA 1U70A 2HM9A 3M08A 3D80A 4Q67A 1VDRA 5U26A 4IXGX 3QLYA 4I13A 1JUVA 1RX6A 2W3MA 3FY8X 4KL9A 3FL8A 4HOGA 3JW5A 1RC4A 3QL3A 4FGGA 2HQPA 1DR1A 3JVXA 3NRRA 1DYRA 1AO8A 4ELFA 1MVSA 4EIGA 4XT6A 1RA8A 3DATA 3FRDX 1RG7A 2W9TA 3NXVA 4P68A 4KEBA 4ECKA 2INQA 3SAIA 4X5IA 4XT5A 3K2HA 3FYWX 1DRBA 3NXYA 4KJJA 1MVTA 3SQYX 3QLSA 3KY8A 3GHCA 3FRAX 1JOMA 6DFRA 1IA4A 4ELGA 1AI9A 4NX6A 4PSSA 2W3WA 1J3IA 3TQBA 4ELBA 2FZIA 4IXED 4DPHA 1E26A 3CL9A 3S9UA 1BOZA 4P66A 3TQAA 1KLKA 1DIUA 4KJKA 3Q1HA 4M7VA 4EIZA 1OHKA 2C2SA 3KFYA 1S3WA 3F91A 1OHJA 3F0UX 3NZ9X 5ECCA 1IA3A 2BLAA 1RA3A 2OIPA 3FQOA
chains in the Genus database with same CATH superfamily
4QLGA 3RG9A 3DAUA 3FYVX 4DFRA 3NXRA 4KFJA 3KJSA 3JWCA 1DHJA 3NZDA 3D84X 2HXVA 1DG7A 3S3VA 2BLBA 3FY9X 3JW3A 2ITHA 3NXOA 3FQVA 4GH8A 2ANOA 3IRNA 3SA1A 1D1GA 4G8ZX 3CD2A 4X5HA 3F0QX 3DFRA 2FZHA 1DDSA 1HFRA 5CCCA 5HSRA 1RE7A 3QYOA 4QHVA 3OCHA 3UM8A 1BZFA 3JTWA 3QG2A 2OBCA 5HF0X 1DISA 3GHWA 2KGKA 4XECX 2QK8A 1DLSA 1S3UA 1RX8A 4OSGA 5HT5A 2W3BA 5HQZA 4I1NA 4HA7A 5ECXA 3IX9A 3OAFA 4QJZD 2W3VA 1DR4A 1HFPA 1RX1A 1RH3A 1LY3A 3F0BX 3FL9A 4IXFX 1PD8A 3FQFA 1KMSA 3JWKA 3SRWX 4KJLA 2W3AA 4EJ1A 4H97A 1DDRA 3FQZA 5HSUA 1RA2A 3E0BA 5JG0X 3TQ9A 2D0KA 2W9SA 4HOEA 4H96A 2ANQA 3NXXA 3QLWA 1M78A 2H2QA 4M6LA 3ZPGA 4LAGX 1M79A 3SRUX 1DYIA 4X5JA 2CD2A 3NXTA 1DRHA 4PSYA 2CIGA 3JWFA 1DR5A 3HBBA 3R33A 4KBNA 8DFRA 4KM0A 3FRBX 4KM2A 4DDRA 2LF1A 1RX5A 3TD8A 4KY8A 1IA1A 1RX2A 1RF7A 3FQCA 4KNEA 3UM6A 4FHBA 4HA9A 3RO9A 5HUIA 1S3VA 2GD9A 5HT4A 3IA5A 2B3ZA 4ELHA 4DP3A 3NTZA 1DR2A 4RGCA 3EEMA 7DFRA 3FRFX 3DGAA 3K74A 4LEKX 4G3MA 3QGTA 1RD7A 4PSTA 4KY4A 1DG5A 2DRCA 3M09A 3ZPCA 1RX4A 1RX7A 4EILA 1PDBA 5U27A 5CC9A 1J3KA 1CD2A 3DL6A 3K45A 4H95A 3SH2A 1YHOA 3DRCA 3EELA 5HF2X 1DHIA 1KMVA 3F0SX 1U72A 3JWMA 1SEJA 5EAJA 1JOLA 1ZDRA 2AZNA 1S3YA 3JSUA 5HVEA 4P3RA 1HFQA 5HQYA 4NX7A 3N0HA 2DHFA 3SR5X 4KYAA 3QLRA 3DG8A 3S7AA 3LG4A 4DPDA 3GHVA 1DR7A 3KJRA 3SRSX 3IROA 5JA3A 3SRQX 3NZCX 3FS6A 3QFXA 3L3RA 3NZAX 1DR6A 3F0XX 3KGYA 1CZ3A 3QLZA 1M7AA 4M6KA 1RX3A 3SRRX 4XE6X 5HI6A 1DR3A 4KD7A 4M2XA 1QZFA 4QI9A 2FZJA 4HOFA 4X5GA 3NU0A 4XT4A 2XW7A 1RA9A 5DXVA 3EEJA 3TQ8A 4XT8A 3INVA 1DG8A 2G6VA 1RB2A 2ZZAA 3I8AX 3QYLA 1PD9A 1RA1A 5FDAA 1IA2A 4Q6AA 1AOEA 1RB3A 2O7PA 5HVBA 3NZ6X 2P4GA 3VCOA 4PTHA 3ROAA 3QL0A 1DAJA 3CSEA 4Q0EA 1DRFA 3SGYA 3QLXA 4QLEA 3K47A 4X5FA 4H98A 4LAEX 2W9HA 3F0VX 4QJCA 1U71A 1VJ3A 2W9GA 2JYBA 3I3RA 1DLRA 4OR7A 4KLXA 4M6JA 4KAKA 1TDRA 4LAHX 4M7UA 2D5NA 4CD2A 1DYJA 3NZBX 3HJ3A 3CLBA 4G95A 3IA4A 1RX9A 3EIGA 3EEKA 1DRAA 4PTJA 1J3JA 5HPBA 4FGHA 3IRMA 3F8ZA 3UM5A 4XRBA 4Q0DA 2BL9A 3F8YA 2C2TA 3GI2A 3SA2A 1LY4A 4TU5X 4QLFA 5E8QA 4XT7A 4PDJA 2L28A 1DYHA 3FREX 3DL5A 3EX8A 3FQ0A 1LUDA 3GYFA 5DFRA 1DHFA 1DREA 4ELEA 4P3QA 1DF7A 2BLCA 1U70A 2HM9A 3M08A 3D80A 4Q67A 1VDRA 5U26A 4IXGX 3QLYA 4I13A 1JUVA 1RX6A 2W3MA 3FY8X 4KL9A 3FL8A 4HOGA 3JW5A 1RC4A 3QL3A 4FGGA 2HQPA 1DR1A 3JVXA 3NRRA 1DYRA 1AO8A 4ELFA 1MVSA 4EIGA 4XT6A 1RA8A 3DATA 3FRDX 1RG7A 2W9TA 3NXVA 4P68A 4KEBA 4ECKA 2INQA 3SAIA 4X5IA 4XT5A 3K2HA 3FYWX 1DRBA 3NXYA 4KJJA 1MVTA 3SQYX 3QLSA 3KY8A 3GHCA 3FRAX 1JOMA 6DFRA 1IA4A 4ELGA 1AI9A 4NX6A 4PSSA 2W3WA 1J3IA 3TQBA 4ELBA 2FZIA 4IXED 4DPHA 1E26A 3CL9A 3S9UA 1BOZA 4P66A 3TQAA 1KLKA 1DIUA 4KJKA 3Q1HA 4M7VA 4EIZA 1OHKA 2C2SA 3KFYA 1S3WA 3F91A 1OHJA 3F0UX 3NZ9X 5ECCA 1IA3A 2BLAA 1RA3A 2OIPA 3FQOA
chains in the Genus database with same CATH topology
4QLGA 3RG9A 3DAUA 3FYVX 4DFRA 3NXRA 4KFJA 3KJSA 3JWCA 1DHJA 3NZDA 3D84X 2HXVA 1DG7A 3S3VA 2BLBA 3FY9X 3JW3A 2ITHA 3NXOA 3FQVA 4GH8A 2ANOA 3IRNA 3SA1A 1D1GA 4G8ZX 3CD2A 4X5HA 3F0QX 3DFRA 2FZHA 1DDSA 1HFRA 5CCCA 5HSRA 1RE7A 3QYOA 4QHVA 3OCHA 3UM8A 1BZFA 3JTWA 3QG2A 2OBCA 5HF0X 1DISA 3GHWA 2KGKA 4XECX 2QK8A 1DLSA 1S3UA 1RX8A 4OSGA 5HT5A 2W3BA 5HQZA 4I1NA 4HA7A 5ECXA 3IX9A 3OAFA 4QJZD 2W3VA 1DR4A 1HFPA 1RX1A 1RH3A 1LY3A 3F0BX 3FL9A 4IXFX 1PD8A 3FQFA 1KMSA 3JWKA 3SRWX 4KJLA 2W3AA 4EJ1A 4H97A 1DDRA 3FQZA 5HSUA 1RA2A 3E0BA 5JG0X 3TQ9A 2D0KA 2W9SA 4HOEA 4H96A 2ANQA 3NXXA 3QLWA 1M78A 2H2QA 4M6LA 3ZPGA 4LAGX 1M79A 3SRUX 1DYIA 4X5JA 2CD2A 3NXTA 1DRHA 4PSYA 2CIGA 3JWFA 1DR5A 3HBBA 3R33A 4KBNA 8DFRA 4KM0A 3FRBX 4KM2A 4DDRA 2LF1A 1RX5A 3TD8A 4KY8A 1IA1A 1RX2A 1RF7A 3FQCA 4KNEA 3UM6A 4FHBA 4HA9A 3RO9A 5HUIA 1S3VA 2GD9A 5HT4A 3IA5A 2B3ZA 4ELHA 4DP3A 3NTZA 1DR2A 4RGCA 3EEMA 7DFRA 3FRFX 3DGAA 3K74A 4LEKX 4G3MA 3QGTA 1RD7A 4PSTA 4KY4A 1DG5A 2DRCA 3M09A 3ZPCA 1RX4A 1RX7A 4EILA 1PDBA 5U27A 5CC9A 1J3KA 1CD2A 3DL6A 3K45A 4H95A 3SH2A 1YHOA 3DRCA 3EELA 5HF2X 1DHIA 1KMVA 3F0SX 1U72A 3JWMA 1SEJA 5EAJA 1JOLA 1ZDRA 2AZNA 1S3YA 3JSUA 5HVEA 4P3RA 1HFQA 5HQYA 4NX7A 3N0HA 2DHFA 3SR5X 4KYAA 3QLRA 3DG8A 3S7AA 3LG4A 4DPDA 3GHVA 1DR7A 3KJRA 3SRSX 3IROA 5JA3A 3SRQX 3NZCX 3FS6A 3QFXA 3L3RA 3NZAX 1DR6A 3F0XX 3KGYA 1CZ3A 3QLZA 1M7AA 4M6KA 1RX3A 3SRRX 4XE6X 5HI6A 1DR3A 4KD7A 4M2XA 1QZFA 4QI9A 2FZJA 4HOFA 4X5GA 3NU0A 4XT4A 2XW7A 1RA9A 5DXVA 3EEJA 3TQ8A 4XT8A 3INVA 1DG8A 2G6VA 1RB2A 2ZZAA 3I8AX 3QYLA 1PD9A 1RA1A 5FDAA 1IA2A 4Q6AA 1AOEA 1RB3A 2O7PA 5HVBA 3NZ6X 2P4GA 3VCOA 4PTHA 3ROAA 3QL0A 1DAJA 3CSEA 4Q0EA 1DRFA 3SGYA 3QLXA 4QLEA 3K47A 4X5FA 4H98A 4LAEX 2W9HA 3F0VX 4QJCA 1U71A 1VJ3A 2W9GA 2JYBA 3I3RA 1DLRA 4OR7A 4KLXA 4M6JA 4KAKA 1TDRA 4LAHX 4M7UA 2D5NA 4CD2A 1DYJA 3NZBX 3HJ3A 3CLBA 4G95A 3IA4A 1RX9A 3EIGA 3EEKA 1DRAA 4PTJA 1J3JA 5HPBA 4FGHA 3IRMA 3F8ZA 3UM5A 4XRBA 4Q0DA 2BL9A 3F8YA 2C2TA 3GI2A 3SA2A 1LY4A 4TU5X 4QLFA 5E8QA 4XT7A 4PDJA 2L28A 1DYHA 3FREX 3DL5A 3EX8A 3FQ0A 1LUDA 3GYFA 5DFRA 1DHFA 1DREA 4ELEA 4P3QA 1DF7A 2BLCA 1U70A 2HM9A 3M08A 3D80A 4Q67A 1VDRA 5U26A 4IXGX 3QLYA 4I13A 1JUVA 1RX6A 2W3MA 3FY8X 4KL9A 3FL8A 4HOGA 3JW5A 1RC4A 3QL3A 4FGGA 2HQPA 1DR1A 3JVXA 3NRRA 1DYRA 1AO8A 4ELFA 1MVSA 4EIGA 4XT6A 1RA8A 3DATA 3FRDX 1RG7A 2W9TA 3NXVA 4P68A 4KEBA 4ECKA 2INQA 3SAIA 4X5IA 4XT5A 3K2HA 3FYWX 1DRBA 3NXYA 4KJJA 1MVTA 3SQYX 3QLSA 3KY8A 3GHCA 3FRAX 1JOMA 6DFRA 1IA4A 4ELGA 1AI9A 4NX6A 4PSSA 2W3WA 1J3IA 3TQBA 4ELBA 2FZIA 4IXED 4DPHA 1E26A 3CL9A 3S9UA 1BOZA 4P66A 3TQAA 1KLKA 1DIUA 4KJKA 3Q1HA 4M7VA 4EIZA 1OHKA 2C2SA 3KFYA 1S3WA 3F91A 1OHJA 3F0UX 3NZ9X 5ECCA 1IA3A 2BLAA 1RA3A 2OIPA 3FQOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QLG A;  3RG9 A;  3DAU A;  3FYV X;  4DFR A;  3NXR A;  4KFJ A;  3KJS A;  3JWC A;  1DHJ A;  3NZD A;  3D84 X;  2HXV A;  1DG7 A;  3S3V A;  2BLB A;  3FY9 X;  3JW3 A;  2ITH A;  3NXO A;  3FQV A;  4GH8 A;  2ANO A;  3IRN A;  3SA1 A;  1D1G A;  4G8Z X;  3CD2 A;  4X5H A;  3F0Q X;  3DFR A;  2FZH A;  1DDS A;  1HFR A;  5CCC A;  5HSR A;  1RE7 A;  3QYO A;  4QHV A;  3OCH A;  3UM8 A;  1BZF A;  3JTW A;  3QG2 A;  2OBC A;  5HF0 X;  1DIS A;  3GHW A;  2KGK A;  4XEC X;  2QK8 A;  1DLS A;  1S3U A;  1RX8 A;  4OSG A;  5HT5 A;  2W3B A;  5HQZ A;  4I1N A;  4HA7 A;  5ECX A;  3IX9 A;  3OAF A;  4QJZ D;  2W3V A;  1DR4 A;  1HFP A;  1RX1 A;  1RH3 A;  1LY3 A;  3F0B X;  3FL9 A;  4IXF X;  1PD8 A;  3FQF A;  1KMS A;  3JWK A;  3SRW X;  4KJL A;  2W3A A;  4EJ1 A;  4H97 A;  1DDR A;  3FQZ A;  5HSU A;  1RA2 A;  3E0B A;  5JG0 X;  3TQ9 A;  2D0K A;  2W9S A;  4HOE A;  4H96 A;  2ANQ A;  3NXX A;  3QLW A;  1M78 A;  2H2Q A;  4M6L A;  3ZPG A;  4LAG X;  1M79 A;  3SRU X;  1DYI A;  4X5J A;  2CD2 A;  3NXT A;  1DRH A;  4PSY A;  2CIG A;  3JWF A;  1DR5 A;  3HBB A;  3R33 A;  4KBN A;  8DFR A;  4KM0 A;  3FRB X;  4KM2 A;  4DDR A;  2LF1 A;  1RX5 A;  3TD8 A;  4KY8 A;  1IA1 A;  1RX2 A;  1RF7 A;  3FQC A;  4KNE A;  3UM6 A;  4FHB A;  4HA9 A;  3RO9 A;  5HUI A;  1S3V A;  2GD9 A;  5HT4 A;  3IA5 A;  2B3Z A;  4ELH A;  4DP3 A;  3NTZ A;  1DR2 A;  4RGC A;  3EEM A;  7DFR A;  3FRF X;  3DGA A;  3K74 A;  4LEK X;  4G3M A;  3QGT A;  1RD7 A;  4PST A;  4KY4 A;  1DG5 A;  2DRC A;  3M09 A;  3ZPC A;  1RX4 A;  1RX7 A;  4EIL A;  1PDB A;  5U27 A;  5CC9 A;  1J3K A;  1CD2 A;  3DL6 A;  3K45 A;  4H95 A;  3SH2 A;  1YHO A;  3DRC A;  3EEL A;  5HF2 X;  1DHI A;  1KMV A;  3F0S X;  1U72 A;  3JWM A;  1SEJ A;  5EAJ A;  1JOL A;  1ZDR A;  2AZN A;  1S3Y A;  3JSU A;  5HVE A;  4P3R A;  1HFQ A;  5HQY A;  4NX7 A;  3N0H A;  2DHF A;  3SR5 X;  4KYA A;  3QLR A;  3DG8 A;  3S7A A;  3LG4 A;  4DPD A;  3GHV A;  1DR7 A;  3KJR A;  3SRS X;  3IRO A;  5JA3 A;  3SRQ X;  3NZC X;  3FS6 A;  3QFX A;  3L3R A;  3NZA X;  1DR6 A;  3F0X X;  3KGY A;  1CZ3 A;  3QLZ A;  1M7A A;  4M6K A;  1RX3 A;  3SRR X;  4XE6 X;  5HI6 A;  1DR3 A;  4KD7 A;  4M2X A;  1QZF A;  4QI9 A;  2FZJ A;  4HOF A;  4X5G A;  3NU0 A;  4XT4 A;  2XW7 A;  1RA9 A;  5DXV A;  3EEJ A;  3TQ8 A;  4XT8 A;  3INV A;  1DG8 A;  2G6V A;  1RB2 A;  2ZZA A;  3I8A X;  3QYL A;  1PD9 A;  1RA1 A;  5FDA A;  1IA2 A;  4Q6A A;  1AOE A;  1RB3 A;  2O7P A;  5HVB A;  3NZ6 X;  2P4G A;  3VCO A;  4PTH A;  3ROA A;  3QL0 A;  1DAJ A;  3CSE A;  4Q0E A;  1DRF A;  3SGY A;  3QLX A;  4QLE A;  3K47 A;  4X5F A;  4H98 A;  4LAE X;  2W9H A;  3F0V X;  4QJC A;  1U71 A;  1VJ3 A;  2W9G A;  2JYB A;  3I3R A;  1DLR A;  4OR7 A;  4KLX A;  4M6J A;  4KAK A;  1TDR A;  4LAH X;  4M7U A;  2D5N A;  4CD2 A;  1DYJ A;  3NZB X;  3HJ3 A;  3CLB A;  4G95 A;  3IA4 A;  1RX9 A;  3EIG A;  3EEK A;  1DRA A;  4PTJ A;  1J3J A;  5HPB A;  4FGH A;  3IRM A;  3F8Z A;  3UM5 A;  4XRB A;  4Q0D A;  2BL9 A;  3F8Y A;  2C2T A;  3GI2 A;  3SA2 A;  1LY4 A;  4TU5 X;  4QLF A;  5E8Q A;  4XT7 A;  4PDJ A;  2L28 A;  1DYH A;  3FRE X;  3DL5 A;  3EX8 A;  3FQ0 A;  1LUD A;  3GYF A;  5DFR A;  1DHF A;  1DRE A;  4ELE A;  4P3Q A;  1DF7 A;  2BLC A;  1U70 A;  2HM9 A;  3M08 A;  3D80 A;  4Q67 A;  1VDR A;  5U26 A;  4IXG X;  3QLY A;  4I13 A;  1JUV A;  1RX6 A;  2W3M A;  3FY8 X;  4KL9 A;  3FL8 A;  4HOG A;  3JW5 A;  1RC4 A;  3QL3 A;  4FGG A;  2HQP A;  1DR1 A;  3JVX A;  3NRR A;  1DYR A;  1AO8 A;  4ELF A;  1MVS A;  4EIG A;  4XT6 A;  1RA8 A;  3DAT A;  3FRD X;  1RG7 A;  2W9T A;  3NXV A;  4P68 A;  4KEB A;  4ECK A;  2INQ A;  3SAI A;  4X5I A;  4XT5 A;  3K2H A;  3FYW X;  1DRB A;  3NXY A;  4KJJ A;  1MVT A;  3SQY X;  3QLS A;  3KY8 A;  3GHC A;  3FRA X;  1JOM A;  6DFR A;  1IA4 A;  4ELG A;  1AI9 A;  4NX6 A;  4PSS A;  2W3W A;  1J3I A;  3TQB A;  4ELB A;  2FZI A;  4IXE D;  4DPH A;  1E26 A;  3CL9 A;  3S9U A;  1BOZ A;  4P66 A;  3TQA A;  1KLK A;  1DIU A;  4KJK A;  3Q1H A;  4M7V A;  4EIZ A;  1OHK A;  2C2S A;  3KFY A;  1S3W A;  3F91 A;  1OHJ A;  3F0U X;  3NZ9 X;  5ECC A;  1IA3 A;  2BLA A;  1RA3 A;  2OIP A;  3FQO A; 
#chains in the Genus database with same CATH topology
 4QLG A;  3RG9 A;  3DAU A;  3FYV X;  4DFR A;  3NXR A;  4KFJ A;  3KJS A;  3JWC A;  1DHJ A;  3NZD A;  3D84 X;  2HXV A;  1DG7 A;  3S3V A;  2BLB A;  3FY9 X;  3JW3 A;  2ITH A;  3NXO A;  3FQV A;  4GH8 A;  2ANO A;  3IRN A;  3SA1 A;  1D1G A;  4G8Z X;  3CD2 A;  4X5H A;  3F0Q X;  3DFR A;  2FZH A;  1DDS A;  1HFR A;  5CCC A;  5HSR A;  1RE7 A;  3QYO A;  4QHV A;  3OCH A;  3UM8 A;  1BZF A;  3JTW A;  3QG2 A;  2OBC A;  5HF0 X;  1DIS A;  3GHW A;  2KGK A;  4XEC X;  2QK8 A;  1DLS A;  1S3U A;  1RX8 A;  4OSG A;  5HT5 A;  2W3B A;  5HQZ A;  4I1N A;  4HA7 A;  5ECX A;  3IX9 A;  3OAF A;  4QJZ D;  2W3V A;  1DR4 A;  1HFP A;  1RX1 A;  1RH3 A;  1LY3 A;  3F0B X;  3FL9 A;  4IXF X;  1PD8 A;  3FQF A;  1KMS A;  3JWK A;  3SRW X;  4KJL A;  2W3A A;  4EJ1 A;  4H97 A;  1DDR A;  3FQZ A;  5HSU A;  1RA2 A;  3E0B A;  5JG0 X;  3TQ9 A;  2D0K A;  2W9S A;  4HOE A;  4H96 A;  2ANQ A;  3NXX A;  3QLW A;  1M78 A;  2H2Q A;  4M6L A;  3ZPG A;  4LAG X;  1M79 A;  3SRU X;  1DYI A;  4X5J A;  2CD2 A;  3NXT A;  1DRH A;  4PSY A;  2CIG A;  3JWF A;  1DR5 A;  3HBB A;  3R33 A;  4KBN A;  8DFR A;  4KM0 A;  3FRB X;  4KM2 A;  4DDR A;  2LF1 A;  1RX5 A;  3TD8 A;  4KY8 A;  1IA1 A;  1RX2 A;  1RF7 A;  3FQC A;  4KNE A;  3UM6 A;  4FHB A;  4HA9 A;  3RO9 A;  5HUI A;  1S3V A;  2GD9 A;  5HT4 A;  3IA5 A;  2B3Z A;  4ELH A;  4DP3 A;  3NTZ A;  1DR2 A;  4RGC A;  3EEM A;  7DFR A;  3FRF X;  3DGA A;  3K74 A;  4LEK X;  4G3M A;  3QGT A;  1RD7 A;  4PST A;  4KY4 A;  1DG5 A;  2DRC A;  3M09 A;  3ZPC A;  1RX4 A;  1RX7 A;  4EIL A;  1PDB A;  5U27 A;  5CC9 A;  1J3K A;  1CD2 A;  3DL6 A;  3K45 A;  4H95 A;  3SH2 A;  1YHO A;  3DRC A;  3EEL A;  5HF2 X;  1DHI A;  1KMV A;  3F0S X;  1U72 A;  3JWM A;  1SEJ A;  5EAJ A;  1JOL A;  1ZDR A;  2AZN A;  1S3Y A;  3JSU A;  5HVE A;  4P3R A;  1HFQ A;  5HQY A;  4NX7 A;  3N0H A;  2DHF A;  3SR5 X;  4KYA A;  3QLR A;  3DG8 A;  3S7A A;  3LG4 A;  4DPD A;  3GHV A;  1DR7 A;  3KJR A;  3SRS X;  3IRO A;  5JA3 A;  3SRQ X;  3NZC X;  3FS6 A;  3QFX A;  3L3R A;  3NZA X;  1DR6 A;  3F0X X;  3KGY A;  1CZ3 A;  3QLZ A;  1M7A A;  4M6K A;  1RX3 A;  3SRR X;  4XE6 X;  5HI6 A;  1DR3 A;  4KD7 A;  4M2X A;  1QZF A;  4QI9 A;  2FZJ A;  4HOF A;  4X5G A;  3NU0 A;  4XT4 A;  2XW7 A;  1RA9 A;  5DXV A;  3EEJ A;  3TQ8 A;  4XT8 A;  3INV A;  1DG8 A;  2G6V A;  1RB2 A;  2ZZA A;  3I8A X;  3QYL A;  1PD9 A;  1RA1 A;  5FDA A;  1IA2 A;  4Q6A A;  1AOE A;  1RB3 A;  2O7P A;  5HVB A;  3NZ6 X;  2P4G A;  3VCO A;  4PTH A;  3ROA A;  3QL0 A;  1DAJ A;  3CSE A;  4Q0E A;  1DRF A;  3SGY A;  3QLX A;  4QLE A;  3K47 A;  4X5F A;  4H98 A;  4LAE X;  2W9H A;  3F0V X;  4QJC A;  1U71 A;  1VJ3 A;  2W9G A;  2JYB A;  3I3R A;  1DLR A;  4OR7 A;  4KLX A;  4M6J A;  4KAK A;  1TDR A;  4LAH X;  4M7U A;  2D5N A;  4CD2 A;  1DYJ A;  3NZB X;  3HJ3 A;  3CLB A;  4G95 A;  3IA4 A;  1RX9 A;  3EIG A;  3EEK A;  1DRA A;  4PTJ A;  1J3J A;  5HPB A;  4FGH A;  3IRM A;  3F8Z A;  3UM5 A;  4XRB A;  4Q0D A;  2BL9 A;  3F8Y A;  2C2T A;  3GI2 A;  3SA2 A;  1LY4 A;  4TU5 X;  4QLF A;  5E8Q A;  4XT7 A;  4PDJ A;  2L28 A;  1DYH A;  3FRE X;  3DL5 A;  3EX8 A;  3FQ0 A;  1LUD A;  3GYF A;  5DFR A;  1DHF A;  1DRE A;  4ELE A;  4P3Q A;  1DF7 A;  2BLC A;  1U70 A;  2HM9 A;  3M08 A;  3D80 A;  4Q67 A;  1VDR A;  5U26 A;  4IXG X;  3QLY A;  4I13 A;  1JUV A;  1RX6 A;  2W3M A;  3FY8 X;  4KL9 A;  3FL8 A;  4HOG A;  3JW5 A;  1RC4 A;  3QL3 A;  4FGG A;  2HQP A;  1DR1 A;  3JVX A;  3NRR A;  1DYR A;  1AO8 A;  4ELF A;  1MVS A;  4EIG A;  4XT6 A;  1RA8 A;  3DAT A;  3FRD X;  1RG7 A;  2W9T A;  3NXV A;  4P68 A;  4KEB A;  4ECK A;  2INQ A;  3SAI A;  4X5I A;  4XT5 A;  3K2H A;  3FYW X;  1DRB A;  3NXY A;  4KJJ A;  1MVT A;  3SQY X;  3QLS A;  3KY8 A;  3GHC A;  3FRA X;  1JOM A;  6DFR A;  1IA4 A;  4ELG A;  1AI9 A;  4NX6 A;  4PSS A;  2W3W A;  1J3I A;  3TQB A;  4ELB A;  2FZI A;  4IXE D;  4DPH A;  1E26 A;  3CL9 A;  3S9U A;  1BOZ A;  4P66 A;  3TQA A;  1KLK A;  1DIU A;  4KJK A;  3Q1H A;  4M7V A;  4EIZ A;  1OHK A;  2C2S A;  3KFY A;  1S3W A;  3F91 A;  1OHJ A;  3F0U X;  3NZ9 X;  5ECC A;  1IA3 A;  2BLA A;  1RA3 A;  2OIP A;  3FQO A; 
#chains in the Genus database with same CATH homology
 4QLG A;  3RG9 A;  3DAU A;  3FYV X;  4DFR A;  3NXR A;  4KFJ A;  3KJS A;  3JWC A;  1DHJ A;  3NZD A;  3D84 X;  2HXV A;  1DG7 A;  3S3V A;  2BLB A;  3FY9 X;  3JW3 A;  2ITH A;  3NXO A;  3FQV A;  4GH8 A;  2ANO A;  3IRN A;  3SA1 A;  1D1G A;  4G8Z X;  3CD2 A;  4X5H A;  3F0Q X;  3DFR A;  2FZH A;  1DDS A;  1HFR A;  5CCC A;  5HSR A;  1RE7 A;  3QYO A;  4QHV A;  3OCH A;  3UM8 A;  1BZF A;  3JTW A;  3QG2 A;  2OBC A;  5HF0 X;  1DIS A;  3GHW A;  2KGK A;  4XEC X;  2QK8 A;  1DLS A;  1S3U A;  1RX8 A;  4OSG A;  5HT5 A;  2W3B A;  5HQZ A;  4I1N A;  4HA7 A;  5ECX A;  3IX9 A;  3OAF A;  4QJZ D;  2W3V A;  1DR4 A;  1HFP A;  1RX1 A;  1RH3 A;  1LY3 A;  3F0B X;  3FL9 A;  4IXF X;  1PD8 A;  3FQF A;  1KMS A;  3JWK A;  3SRW X;  4KJL A;  2W3A A;  4EJ1 A;  4H97 A;  1DDR A;  3FQZ A;  5HSU A;  1RA2 A;  3E0B A;  5JG0 X;  3TQ9 A;  2D0K A;  2W9S A;  4HOE A;  4H96 A;  2ANQ A;  3NXX A;  3QLW A;  1M78 A;  2H2Q A;  4M6L A;  3ZPG A;  4LAG X;  1M79 A;  3SRU X;  1DYI A;  4X5J A;  2CD2 A;  3NXT A;  1DRH A;  4PSY A;  2CIG A;  3JWF A;  1DR5 A;  3HBB A;  3R33 A;  4KBN A;  8DFR A;  4KM0 A;  3FRB X;  4KM2 A;  4DDR A;  2LF1 A;  1RX5 A;  3TD8 A;  4KY8 A;  1IA1 A;  1RX2 A;  1RF7 A;  3FQC A;  4KNE A;  3UM6 A;  4FHB A;  4HA9 A;  3RO9 A;  5HUI A;  1S3V A;  2GD9 A;  5HT4 A;  3IA5 A;  2B3Z A;  4ELH A;  4DP3 A;  3NTZ A;  1DR2 A;  4RGC A;  3EEM A;  7DFR A;  3FRF X;  3DGA A;  3K74 A;  4LEK X;  4G3M A;  3QGT A;  1RD7 A;  4PST A;  4KY4 A;  1DG5 A;  2DRC A;  3M09 A;  3ZPC A;  1RX4 A;  1RX7 A;  4EIL A;  1PDB A;  5U27 A;  5CC9 A;  1J3K A;  1CD2 A;  3DL6 A;  3K45 A;  4H95 A;  3SH2 A;  1YHO A;  3DRC A;  3EEL A;  5HF2 X;  1DHI A;  1KMV A;  3F0S X;  1U72 A;  3JWM A;  1SEJ A;  5EAJ A;  1JOL A;  1ZDR A;  2AZN A;  1S3Y A;  3JSU A;  5HVE A;  4P3R A;  1HFQ A;  5HQY A;  4NX7 A;  3N0H A;  2DHF A;  3SR5 X;  4KYA A;  3QLR A;  3DG8 A;  3S7A A;  3LG4 A;  4DPD A;  3GHV A;  1DR7 A;  3KJR A;  3SRS X;  3IRO A;  5JA3 A;  3SRQ X;  3NZC X;  3FS6 A;  3QFX A;  3L3R A;  3NZA X;  1DR6 A;  3F0X X;  3KGY A;  1CZ3 A;  3QLZ A;  1M7A A;  4M6K A;  1RX3 A;  3SRR X;  4XE6 X;  5HI6 A;  1DR3 A;  4KD7 A;  4M2X A;  1QZF A;  4QI9 A;  2FZJ A;  4HOF A;  4X5G A;  3NU0 A;  4XT4 A;  2XW7 A;  1RA9 A;  5DXV A;  3EEJ A;  3TQ8 A;  4XT8 A;  3INV A;  1DG8 A;  2G6V A;  1RB2 A;  2ZZA A;  3I8A X;  3QYL A;  1PD9 A;  1RA1 A;  5FDA A;  1IA2 A;  4Q6A A;  1AOE A;  1RB3 A;  2O7P A;  5HVB A;  3NZ6 X;  2P4G A;  3VCO A;  4PTH A;  3ROA A;  3QL0 A;  1DAJ A;  3CSE A;  4Q0E A;  1DRF A;  3SGY A;  3QLX A;  4QLE A;  3K47 A;  4X5F A;  4H98 A;  4LAE X;  2W9H A;  3F0V X;  4QJC A;  1U71 A;  1VJ3 A;  2W9G A;  2JYB A;  3I3R A;  1DLR A;  4OR7 A;  4KLX A;  4M6J A;  4KAK A;  1TDR A;  4LAH X;  4M7U A;  2D5N A;  4CD2 A;  1DYJ A;  3NZB X;  3HJ3 A;  3CLB A;  4G95 A;  3IA4 A;  1RX9 A;  3EIG A;  3EEK A;  1DRA A;  4PTJ A;  1J3J A;  5HPB A;  4FGH A;  3IRM A;  3F8Z A;  3UM5 A;  4XRB A;  4Q0D A;  2BL9 A;  3F8Y A;  2C2T A;  3GI2 A;  3SA2 A;  1LY4 A;  4TU5 X;  4QLF A;  5E8Q A;  4XT7 A;  4PDJ A;  2L28 A;  1DYH A;  3FRE X;  3DL5 A;  3EX8 A;  3FQ0 A;  1LUD A;  3GYF A;  5DFR A;  1DHF A;  1DRE A;  4ELE A;  4P3Q A;  1DF7 A;  2BLC A;  1U70 A;  2HM9 A;  3M08 A;  3D80 A;  4Q67 A;  1VDR A;  5U26 A;  4IXG X;  3QLY A;  4I13 A;  1JUV A;  1RX6 A;  2W3M A;  3FY8 X;  4KL9 A;  3FL8 A;  4HOG A;  3JW5 A;  1RC4 A;  3QL3 A;  4FGG A;  2HQP A;  1DR1 A;  3JVX A;  3NRR A;  1DYR A;  1AO8 A;  4ELF A;  1MVS A;  4EIG A;  4XT6 A;  1RA8 A;  3DAT A;  3FRD X;  1RG7 A;  2W9T A;  3NXV A;  4P68 A;  4KEB A;  4ECK A;  2INQ A;  3SAI A;  4X5I A;  4XT5 A;  3K2H A;  3FYW X;  1DRB A;  3NXY A;  4KJJ A;  1MVT A;  3SQY X;  3QLS A;  3KY8 A;  3GHC A;  3FRA X;  1JOM A;  6DFR A;  1IA4 A;  4ELG A;  1AI9 A;  4NX6 A;  4PSS A;  2W3W A;  1J3I A;  3TQB A;  4ELB A;  2FZI A;  4IXE D;  4DPH A;  1E26 A;  3CL9 A;  3S9U A;  1BOZ A;  4P66 A;  3TQA A;  1KLK A;  1DIU A;  4KJK A;  3Q1H A;  4M7V A;  4EIZ A;  1OHK A;  2C2S A;  3KFY A;  1S3W A;  3F91 A;  1OHJ A;  3F0U X;  3NZ9 X;  5ECC A;  1IA3 A;  2BLA A;  1RA3 A;  2OIP A;  3FQO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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