1DRHA

Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
pubmed doi rcsb
molecule keywords DIHYDROFOLATE REDUCTASE
molecule tags Oxidoreductase
source organism Escherichia coli
total genus 40
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1994-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1drhA00
4G8ZX 3TQAA 2W3AA 4ELFA 1RX6A 4KM0A 6DFRA 1DYHA 3QYLA 4M7VA 4XT4A 5HI6A 3IROA 2FZHA 3HBBA 1DHFA 4HA9A 3D84X 1DLRA 3KJRA 7DFRA 1DIUA 1ZDRA 4KD7A 3OCHA 4X5GA 1RD7A 2W9SA 1RX5A 3SRQX 1RX9A 3F0BX 4X5HA 3JWMA 1IA1A 1M79A 3K47A 1DDSA 5HQYA 1DLSA 2W3WA 3FYWX 4KYAA 3SR5X 1RA1A 3SQYX 1CZ3A 3IA4A 2ANOA 4QLFA 1JUVA 1RH3A 3SGYA 1OHKA 1JOLA 3FQCA 3ZPCA 3TQ9A 3LG4A 2C2SA 4DPHA 1S3UA 4PSYA 3QG2A 3NXVA 1J3KA 3QL3A 1J3IA 4H97A 2D0KA 3JSUA 1LY4A 3NZ6X 3NTZA 3QGTA 1U72A 5HQZA 3JW3A 3EEMA 4QHVA 4RGCA 3HJ3A 5CC9A 3FYVX 1RF7A 4PTJA 3F8YA 4XE6X 3QL0A 3FRFX 4DP3A 2O7PA 3QLRA 3FREX 3GYFA 1HFRA 3I8AX 4DDRA 3F0QX 3UM5A 1DDRA 1RX2A 3L3RA 5DXVA 3QLWA 1DYJA 1LUDA 4ELGA 5CCCA 3JWCA 3K74A 3NZCX 3UM6A 2CD2A 1DISA 2KGKA 2ZZAA 3NRRA 3DAUA 3FY8X 1RA2A 2B3ZA 4KL9A 3NXYA 1IA2A 4KAKA 4PSTA 4TU5X 4PTHA 4KM2A 1S3YA 1DRAA 4ELBA 3KGYA 3DG8A 4P68A 3KJSA 3JW5A 4M7UA 5EAJA 4KY4A 4X5JA 4Q0EA 4KBNA 1AI9A 3QLSA 4KFJA 4OSGA 3SRRX 1KMSA 5HPBA 3DL6A 1DR1A 4XT8A 1DR3A 2P4GA 3FQZA 1RG7A 1RA3A 4FGGA 4XRBA 4Q67A 1RA9A 1QZFA 4HOGA 3FRBX 3FL9A 1PDBA 3GHCA 3EELA 1AO8A 1JOMA 2H2QA 3DGAA 3GHWA 3FL8A 1E26A 2W3MA 3CL9A 3KY8A 3IA5A 4ELHA 4QI9A 4FHBA 3SRSX 3SA2A 1IA4A 1RB2A 5HT5A 3IRMA 4M6LA 3TQ8A 2OBCA 5HUIA 3F0UX 4IXGX 4NX6A 1RX8A 3D80A 1DYRA 3FS6A 5FDAA 4DPDA 3E0BA 3CLBA 4KLXA 4I13A 1DF7A 1DREA 3F0XX 2DHFA 3F91A 1OHJA 4IXFX 1DR2A 1RC4A 3DRCA 3QLYA 4KEBA 3FQVA 1DRHA 3F0VX 4EIGA 4QJCA 4DFRA 1VDRA 4KJJA 1DYIA 3GHVA 4GH8A 5U27A 1HFPA 2D5NA 4OR7A 4H96A 3FRDX 4PSSA 4PDJA 4XECX 1CD2A 2JYBA 3S7AA 3ROAA 2ANQA 2DRCA 1LY3A 3S9UA 2BLCA 1M7AA 5HSUA 3FRAX 4Q6AA 4ECKA 4I1NA 1DHJA 1BOZA 4QLEA 3CD2A 4P3RA 1IA3A 3FQFA 2L28A 4M2XA 3SRUX 3EEKA 1DAJA 3CSEA 5U26A 4QJZD 3EX8A 2BLAA 4XT6A 4P66A 2XW7A 2FZJA 3S3VA 3IX9A 5JA3A 4HOEA 1M78A 1VJ3A 3NZ9X 3IRNA 4KY8A 4XT7A 4G3MA 3NXOA 4LAEX 4X5IA 2QK8A 3JWKA 2CIGA 2BL9A 3INVA 2W3VA 3NZAX 3EIGA 3OAFA 5HF0X 4KJLA 2W9GA 3F8ZA 3SH2A 5HVBA 3QLXA 4XT5A 4KJKA 4H95A 3DATA 2ITHA 4LAGX 1D1GA 3RG9A 1MVSA 3SA1A 1PD9A 2C2TA 5ECXA 5DFRA 3UM8A 3SRWX 5ECCA 3JVXA 1DR5A 1DR6A 4QLGA 2W3BA 3TD8A 1RA8A 2BLBA 2W9TA 3QLZA 4LAHX 1RB3A 3GI2A 1AOEA 4P3QA 1RX4A 4LEKX 3NZBX 8DFRA 1U71A 4KNEA 1SEJA 4M6KA 4EIZA 1DR4A 3RO9A 1U70A 2G6VA 2HM9A 1KLKA 3I3RA 3DL5A 2HXVA 4Q0DA 1DRFA 1J3JA 1YHOA 2LF1A 5HF2X 1MVTA 3N0HA 1RX7A 3KFYA 4NX7A 1DR7A 1TDRA 3SAIA 1RE7A 3NXRA 4EJ1A 1DHIA 4CD2A 3JTWA 3JWFA 3M08A 4G95A 2INQA 3FQOA 1HFQA 3ZPGA 2AZNA 1S3VA 2HQPA 2GD9A 4M6JA 3FY9X 1PD8A 1DG5A 3QYOA 4EILA 3NXTA 3K2HA 1DG8A 5HVEA 3F0SX 1S3WA 4IXED 3Q1HA 2OIPA 4H98A 3NU0A 3VCOA 5HT4A 4ELEA 1RX3A 3QFXA 1DG7A 3M09A 1RX1A 5HSRA 5E8QA 1BZFA 4FGHA 1DRBA 3DFRA 3R33A 1KMVA 3FQ0A 4HOFA 4X5FA 3K45A 4HA7A 3TQBA 2W9HA 3EEJA 3NZDA 5JG0X 2FZIA 3NXXA
chains in the Genus database with same CATH superfamily
4G8ZX 3TQAA 2W3AA 4ELFA 1RX6A 4KM0A 6DFRA 1DYHA 3QYLA 4M7VA 4XT4A 5HI6A 3IROA 2FZHA 3HBBA 1DHFA 4HA9A 3D84X 1DLRA 3KJRA 7DFRA 1DIUA 1ZDRA 4KD7A 3OCHA 4X5GA 1RD7A 2W9SA 1RX5A 3SRQX 1RX9A 3F0BX 4X5HA 3JWMA 1IA1A 1M79A 3K47A 1DDSA 5HQYA 1DLSA 2W3WA 3FYWX 4KYAA 3SR5X 1RA1A 3SQYX 1CZ3A 3IA4A 2ANOA 4QLFA 1JUVA 1RH3A 3SGYA 1OHKA 1JOLA 3FQCA 3ZPCA 3TQ9A 3LG4A 2C2SA 4DPHA 1S3UA 4PSYA 3QG2A 3NXVA 1J3KA 3QL3A 1J3IA 4H97A 2D0KA 3JSUA 1LY4A 3NZ6X 3NTZA 3QGTA 1U72A 5HQZA 3JW3A 3EEMA 4QHVA 4RGCA 3HJ3A 5CC9A 3FYVX 1RF7A 4PTJA 3F8YA 4XE6X 3QL0A 3FRFX 4DP3A 2O7PA 3QLRA 3FREX 3GYFA 1HFRA 3I8AX 4DDRA 3F0QX 3UM5A 1DDRA 1RX2A 3L3RA 5DXVA 3QLWA 1DYJA 1LUDA 4ELGA 5CCCA 3JWCA 3K74A 3NZCX 3UM6A 2CD2A 1DISA 2KGKA 2ZZAA 3NRRA 3DAUA 3FY8X 1RA2A 2B3ZA 4KL9A 3NXYA 1IA2A 4KAKA 4PSTA 4TU5X 4PTHA 4KM2A 1S3YA 1DRAA 4ELBA 3KGYA 3DG8A 4P68A 3KJSA 3JW5A 4M7UA 5EAJA 4KY4A 4X5JA 4Q0EA 4KBNA 1AI9A 3QLSA 4KFJA 4OSGA 3SRRX 1KMSA 5HPBA 3DL6A 1DR1A 4XT8A 1DR3A 2P4GA 3FQZA 1RG7A 1RA3A 4FGGA 4XRBA 4Q67A 1RA9A 1QZFA 4HOGA 3FRBX 3FL9A 1PDBA 3GHCA 3EELA 1AO8A 1JOMA 2H2QA 3DGAA 3GHWA 3FL8A 1E26A 2W3MA 3CL9A 3KY8A 3IA5A 4ELHA 4QI9A 4FHBA 3SRSX 3SA2A 1IA4A 1RB2A 5HT5A 3IRMA 4M6LA 3TQ8A 2OBCA 5HUIA 3F0UX 4IXGX 4NX6A 1RX8A 3D80A 1DYRA 3FS6A 5FDAA 4DPDA 3E0BA 3CLBA 4KLXA 4I13A 1DF7A 1DREA 3F0XX 2DHFA 3F91A 1OHJA 4IXFX 1DR2A 1RC4A 3DRCA 3QLYA 4KEBA 3FQVA 1DRHA 3F0VX 4EIGA 4QJCA 4DFRA 1VDRA 4KJJA 1DYIA 3GHVA 4GH8A 5U27A 1HFPA 2D5NA 4OR7A 4H96A 3FRDX 4PSSA 4PDJA 4XECX 1CD2A 2JYBA 3S7AA 3ROAA 2ANQA 2DRCA 1LY3A 3S9UA 2BLCA 1M7AA 5HSUA 3FRAX 4Q6AA 4ECKA 4I1NA 1DHJA 1BOZA 4QLEA 3CD2A 4P3RA 1IA3A 3FQFA 2L28A 4M2XA 3SRUX 3EEKA 1DAJA 3CSEA 5U26A 4QJZD 3EX8A 2BLAA 4XT6A 4P66A 2XW7A 2FZJA 3S3VA 3IX9A 5JA3A 4HOEA 1M78A 1VJ3A 3NZ9X 3IRNA 4KY8A 4XT7A 4G3MA 3NXOA 4LAEX 4X5IA 2QK8A 3JWKA 2CIGA 2BL9A 3INVA 2W3VA 3NZAX 3EIGA 3OAFA 5HF0X 4KJLA 2W9GA 3F8ZA 3SH2A 5HVBA 3QLXA 4XT5A 4KJKA 4H95A 3DATA 2ITHA 4LAGX 1D1GA 3RG9A 1MVSA 3SA1A 1PD9A 2C2TA 5ECXA 5DFRA 3UM8A 3SRWX 5ECCA 3JVXA 1DR5A 1DR6A 4QLGA 2W3BA 3TD8A 1RA8A 2BLBA 2W9TA 3QLZA 4LAHX 1RB3A 3GI2A 1AOEA 4P3QA 1RX4A 4LEKX 3NZBX 8DFRA 1U71A 4KNEA 1SEJA 4M6KA 4EIZA 1DR4A 3RO9A 1U70A 2G6VA 2HM9A 1KLKA 3I3RA 3DL5A 2HXVA 4Q0DA 1DRFA 1J3JA 1YHOA 2LF1A 5HF2X 1MVTA 3N0HA 1RX7A 3KFYA 4NX7A 1DR7A 1TDRA 3SAIA 1RE7A 3NXRA 4EJ1A 1DHIA 4CD2A 3JTWA 3JWFA 3M08A 4G95A 2INQA 3FQOA 1HFQA 3ZPGA 2AZNA 1S3VA 2HQPA 2GD9A 4M6JA 3FY9X 1PD8A 1DG5A 3QYOA 4EILA 3NXTA 3K2HA 1DG8A 5HVEA 3F0SX 1S3WA 4IXED 3Q1HA 2OIPA 4H98A 3NU0A 3VCOA 5HT4A 4ELEA 1RX3A 3QFXA 1DG7A 3M09A 1RX1A 5HSRA 5E8QA 1BZFA 4FGHA 1DRBA 3DFRA 3R33A 1KMVA 3FQ0A 4HOFA 4X5FA 3K45A 4HA7A 3TQBA 2W9HA 3EEJA 3NZDA 5JG0X 2FZIA 3NXXA
chains in the Genus database with same CATH topology
4G8ZX 3TQAA 2W3AA 4ELFA 1RX6A 4KM0A 6DFRA 1DYHA 3QYLA 4M7VA 4XT4A 5HI6A 3IROA 2FZHA 3HBBA 1DHFA 4HA9A 3D84X 1DLRA 3KJRA 7DFRA 1DIUA 1ZDRA 4KD7A 3OCHA 4X5GA 1RD7A 2W9SA 1RX5A 3SRQX 1RX9A 3F0BX 4X5HA 3JWMA 1IA1A 1M79A 3K47A 1DDSA 5HQYA 1DLSA 2W3WA 3FYWX 4KYAA 3SR5X 1RA1A 3SQYX 1CZ3A 3IA4A 2ANOA 4QLFA 1JUVA 1RH3A 3SGYA 1OHKA 1JOLA 3FQCA 3ZPCA 3TQ9A 3LG4A 2C2SA 4DPHA 1S3UA 4PSYA 3QG2A 3NXVA 1J3KA 3QL3A 1J3IA 4H97A 2D0KA 3JSUA 1LY4A 3NZ6X 3NTZA 3QGTA 1U72A 5HQZA 3JW3A 3EEMA 4QHVA 4RGCA 3HJ3A 5CC9A 3FYVX 1RF7A 4PTJA 3F8YA 4XE6X 3QL0A 3FRFX 4DP3A 2O7PA 3QLRA 3FREX 3GYFA 1HFRA 3I8AX 4DDRA 3F0QX 3UM5A 1DDRA 1RX2A 3L3RA 5DXVA 3QLWA 1DYJA 1LUDA 4ELGA 5CCCA 3JWCA 3K74A 3NZCX 3UM6A 2CD2A 1DISA 2KGKA 2ZZAA 3NRRA 3DAUA 3FY8X 1RA2A 2B3ZA 4KL9A 3NXYA 1IA2A 4KAKA 4PSTA 4TU5X 4PTHA 4KM2A 1S3YA 1DRAA 4ELBA 3KGYA 3DG8A 4P68A 3KJSA 3JW5A 4M7UA 5EAJA 4KY4A 4X5JA 4Q0EA 4KBNA 1AI9A 3QLSA 4KFJA 4OSGA 3SRRX 1KMSA 5HPBA 3DL6A 1DR1A 4XT8A 1DR3A 2P4GA 3FQZA 1RG7A 1RA3A 4FGGA 4XRBA 4Q67A 1RA9A 1QZFA 4HOGA 3FRBX 3FL9A 1PDBA 3GHCA 3EELA 1AO8A 1JOMA 2H2QA 3DGAA 3GHWA 3FL8A 1E26A 2W3MA 3CL9A 3KY8A 3IA5A 4ELHA 4QI9A 4FHBA 3SRSX 3SA2A 1IA4A 1RB2A 5HT5A 3IRMA 4M6LA 3TQ8A 2OBCA 5HUIA 3F0UX 4IXGX 4NX6A 1RX8A 3D80A 1DYRA 3FS6A 5FDAA 4DPDA 3E0BA 3CLBA 4KLXA 4I13A 1DF7A 1DREA 3F0XX 2DHFA 3F91A 1OHJA 4IXFX 1DR2A 1RC4A 3DRCA 3QLYA 4KEBA 3FQVA 1DRHA 3F0VX 4EIGA 4QJCA 4DFRA 1VDRA 4KJJA 1DYIA 3GHVA 4GH8A 5U27A 1HFPA 2D5NA 4OR7A 4H96A 3FRDX 4PSSA 4PDJA 4XECX 1CD2A 2JYBA 3S7AA 3ROAA 2ANQA 2DRCA 1LY3A 3S9UA 2BLCA 1M7AA 5HSUA 3FRAX 4Q6AA 4ECKA 4I1NA 1DHJA 1BOZA 4QLEA 3CD2A 4P3RA 1IA3A 3FQFA 2L28A 4M2XA 3SRUX 3EEKA 1DAJA 3CSEA 5U26A 4QJZD 3EX8A 2BLAA 4XT6A 4P66A 2XW7A 2FZJA 3S3VA 3IX9A 5JA3A 4HOEA 1M78A 1VJ3A 3NZ9X 3IRNA 4KY8A 4XT7A 4G3MA 3NXOA 4LAEX 4X5IA 2QK8A 3JWKA 2CIGA 2BL9A 3INVA 2W3VA 3NZAX 3EIGA 3OAFA 5HF0X 4KJLA 2W9GA 3F8ZA 3SH2A 5HVBA 3QLXA 4XT5A 4KJKA 4H95A 3DATA 2ITHA 4LAGX 1D1GA 3RG9A 1MVSA 3SA1A 1PD9A 2C2TA 5ECXA 5DFRA 3UM8A 3SRWX 5ECCA 3JVXA 1DR5A 1DR6A 4QLGA 2W3BA 3TD8A 1RA8A 2BLBA 2W9TA 3QLZA 4LAHX 1RB3A 3GI2A 1AOEA 4P3QA 1RX4A 4LEKX 3NZBX 8DFRA 1U71A 4KNEA 1SEJA 4M6KA 4EIZA 1DR4A 3RO9A 1U70A 2G6VA 2HM9A 1KLKA 3I3RA 3DL5A 2HXVA 4Q0DA 1DRFA 1J3JA 1YHOA 2LF1A 5HF2X 1MVTA 3N0HA 1RX7A 3KFYA 4NX7A 1DR7A 1TDRA 3SAIA 1RE7A 3NXRA 4EJ1A 1DHIA 4CD2A 3JTWA 3JWFA 3M08A 4G95A 2INQA 3FQOA 1HFQA 3ZPGA 2AZNA 1S3VA 2HQPA 2GD9A 4M6JA 3FY9X 1PD8A 1DG5A 3QYOA 4EILA 3NXTA 3K2HA 1DG8A 5HVEA 3F0SX 1S3WA 4IXED 3Q1HA 2OIPA 4H98A 3NU0A 3VCOA 5HT4A 4ELEA 1RX3A 3QFXA 1DG7A 3M09A 1RX1A 5HSRA 5E8QA 1BZFA 4FGHA 1DRBA 3DFRA 3R33A 1KMVA 3FQ0A 4HOFA 4X5FA 3K45A 4HA7A 3TQBA 2W9HA 3EEJA 3NZDA 5JG0X 2FZIA 3NXXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4G8Z X;  3TQA A;  2W3A A;  4ELF A;  1RX6 A;  4KM0 A;  6DFR A;  1DYH A;  3QYL A;  4M7V A;  4XT4 A;  5HI6 A;  3IRO A;  2FZH A;  3HBB A;  1DHF A;  4HA9 A;  3D84 X;  1DLR A;  3KJR A;  7DFR A;  1DIU A;  1ZDR A;  4KD7 A;  3OCH A;  4X5G A;  1RD7 A;  2W9S A;  1RX5 A;  3SRQ X;  1RX9 A;  3F0B X;  4X5H A;  3JWM A;  1IA1 A;  1M79 A;  3K47 A;  1DDS A;  5HQY A;  1DLS A;  2W3W A;  3FYW X;  4KYA A;  3SR5 X;  1RA1 A;  3SQY X;  1CZ3 A;  3IA4 A;  2ANO A;  4QLF A;  1JUV A;  1RH3 A;  3SGY A;  1OHK A;  1JOL A;  3FQC A;  3ZPC A;  3TQ9 A;  3LG4 A;  2C2S A;  4DPH A;  1S3U A;  4PSY A;  3QG2 A;  3NXV A;  1J3K A;  3QL3 A;  1J3I A;  4H97 A;  2D0K A;  3JSU A;  1LY4 A;  3NZ6 X;  3NTZ A;  3QGT A;  1U72 A;  5HQZ A;  3JW3 A;  3EEM A;  4QHV A;  4RGC A;  3HJ3 A;  5CC9 A;  3FYV X;  1RF7 A;  4PTJ A;  3F8Y A;  4XE6 X;  3QL0 A;  3FRF X;  4DP3 A;  2O7P A;  3QLR A;  3FRE X;  3GYF A;  1HFR A;  3I8A X;  4DDR A;  3F0Q X;  3UM5 A;  1DDR A;  1RX2 A;  3L3R A;  5DXV A;  3QLW A;  1DYJ A;  1LUD A;  4ELG A;  5CCC A;  3JWC A;  3K74 A;  3NZC X;  3UM6 A;  2CD2 A;  1DIS A;  2KGK A;  2ZZA A;  3NRR A;  3DAU A;  3FY8 X;  1RA2 A;  2B3Z A;  4KL9 A;  3NXY A;  1IA2 A;  4KAK A;  4PST A;  4TU5 X;  4PTH A;  4KM2 A;  1S3Y A;  1DRA A;  4ELB A;  3KGY A;  3DG8 A;  4P68 A;  3KJS A;  3JW5 A;  4M7U A;  5EAJ A;  4KY4 A;  4X5J A;  4Q0E A;  4KBN A;  1AI9 A;  3QLS A;  4KFJ A;  4OSG A;  3SRR X;  1KMS A;  5HPB A;  3DL6 A;  1DR1 A;  4XT8 A;  1DR3 A;  2P4G A;  3FQZ A;  1RG7 A;  1RA3 A;  4FGG A;  4XRB A;  4Q67 A;  1RA9 A;  1QZF A;  4HOG A;  3FRB X;  3FL9 A;  1PDB A;  3GHC A;  3EEL A;  1AO8 A;  1JOM A;  2H2Q A;  3DGA A;  3GHW A;  3FL8 A;  1E26 A;  2W3M A;  3CL9 A;  3KY8 A;  3IA5 A;  4ELH A;  4QI9 A;  4FHB A;  3SRS X;  3SA2 A;  1IA4 A;  1RB2 A;  5HT5 A;  3IRM A;  4M6L A;  3TQ8 A;  2OBC A;  5HUI A;  3F0U X;  4IXG X;  4NX6 A;  1RX8 A;  3D80 A;  1DYR A;  3FS6 A;  5FDA A;  4DPD A;  3E0B A;  3CLB A;  4KLX A;  4I13 A;  1DF7 A;  1DRE A;  3F0X X;  2DHF A;  3F91 A;  1OHJ A;  4IXF X;  1DR2 A;  1RC4 A;  3DRC A;  3QLY A;  4KEB A;  3FQV A;  1DRH A;  3F0V X;  4EIG A;  4QJC A;  4DFR A;  1VDR A;  4KJJ A;  1DYI A;  3GHV A;  4GH8 A;  5U27 A;  1HFP A;  2D5N A;  4OR7 A;  4H96 A;  3FRD X;  4PSS A;  4PDJ A;  4XEC X;  1CD2 A;  2JYB A;  3S7A A;  3ROA A;  2ANQ A;  2DRC A;  1LY3 A;  3S9U A;  2BLC A;  1M7A A;  5HSU A;  3FRA X;  4Q6A A;  4ECK A;  4I1N A;  1DHJ A;  1BOZ A;  4QLE A;  3CD2 A;  4P3R A;  1IA3 A;  3FQF A;  2L28 A;  4M2X A;  3SRU X;  3EEK A;  1DAJ A;  3CSE A;  5U26 A;  4QJZ D;  3EX8 A;  2BLA A;  4XT6 A;  4P66 A;  2XW7 A;  2FZJ A;  3S3V A;  3IX9 A;  5JA3 A;  4HOE A;  1M78 A;  1VJ3 A;  3NZ9 X;  3IRN A;  4KY8 A;  4XT7 A;  4G3M A;  3NXO A;  4LAE X;  4X5I A;  2QK8 A;  3JWK A;  2CIG A;  2BL9 A;  3INV A;  2W3V A;  3NZA X;  3EIG A;  3OAF A;  5HF0 X;  4KJL A;  2W9G A;  3F8Z A;  3SH2 A;  5HVB A;  3QLX A;  4XT5 A;  4KJK A;  4H95 A;  3DAT A;  2ITH A;  4LAG X;  1D1G A;  3RG9 A;  1MVS A;  3SA1 A;  1PD9 A;  2C2T A;  5ECX A;  5DFR A;  3UM8 A;  3SRW X;  5ECC A;  3JVX A;  1DR5 A;  1DR6 A;  4QLG A;  2W3B A;  3TD8 A;  1RA8 A;  2BLB A;  2W9T A;  3QLZ A;  4LAH X;  1RB3 A;  3GI2 A;  1AOE A;  4P3Q A;  1RX4 A;  4LEK X;  3NZB X;  8DFR A;  1U71 A;  4KNE A;  1SEJ A;  4M6K A;  4EIZ A;  1DR4 A;  3RO9 A;  1U70 A;  2G6V A;  2HM9 A;  1KLK A;  3I3R A;  3DL5 A;  2HXV A;  4Q0D A;  1DRF A;  1J3J A;  1YHO A;  2LF1 A;  5HF2 X;  1MVT A;  3N0H A;  1RX7 A;  3KFY A;  4NX7 A;  1DR7 A;  1TDR A;  3SAI A;  1RE7 A;  3NXR A;  4EJ1 A;  1DHI A;  4CD2 A;  3JTW A;  3JWF A;  3M08 A;  4G95 A;  2INQ A;  3FQO A;  1HFQ A;  3ZPG A;  2AZN A;  1S3V A;  2HQP A;  2GD9 A;  4M6J A;  3FY9 X;  1PD8 A;  1DG5 A;  3QYO A;  4EIL A;  3NXT A;  3K2H A;  1DG8 A;  5HVE A;  3F0S X;  1S3W A;  4IXE D;  3Q1H A;  2OIP A;  4H98 A;  3NU0 A;  3VCO A;  5HT4 A;  4ELE A;  1RX3 A;  3QFX A;  1DG7 A;  3M09 A;  1RX1 A;  5HSR A;  5E8Q A;  1BZF A;  4FGH A;  1DRB A;  3DFR A;  3R33 A;  1KMV A;  3FQ0 A;  4HOF A;  4X5F A;  3K45 A;  4HA7 A;  3TQB A;  2W9H A;  3EEJ A;  3NZD A;  5JG0 X;  2FZI A;  3NXX A; 
#chains in the Genus database with same CATH topology
 4G8Z X;  3TQA A;  2W3A A;  4ELF A;  1RX6 A;  4KM0 A;  6DFR A;  1DYH A;  3QYL A;  4M7V A;  4XT4 A;  5HI6 A;  3IRO A;  2FZH A;  3HBB A;  1DHF A;  4HA9 A;  3D84 X;  1DLR A;  3KJR A;  7DFR A;  1DIU A;  1ZDR A;  4KD7 A;  3OCH A;  4X5G A;  1RD7 A;  2W9S A;  1RX5 A;  3SRQ X;  1RX9 A;  3F0B X;  4X5H A;  3JWM A;  1IA1 A;  1M79 A;  3K47 A;  1DDS A;  5HQY A;  1DLS A;  2W3W A;  3FYW X;  4KYA A;  3SR5 X;  1RA1 A;  3SQY X;  1CZ3 A;  3IA4 A;  2ANO A;  4QLF A;  1JUV A;  1RH3 A;  3SGY A;  1OHK A;  1JOL A;  3FQC A;  3ZPC A;  3TQ9 A;  3LG4 A;  2C2S A;  4DPH A;  1S3U A;  4PSY A;  3QG2 A;  3NXV A;  1J3K A;  3QL3 A;  1J3I A;  4H97 A;  2D0K A;  3JSU A;  1LY4 A;  3NZ6 X;  3NTZ A;  3QGT A;  1U72 A;  5HQZ A;  3JW3 A;  3EEM A;  4QHV A;  4RGC A;  3HJ3 A;  5CC9 A;  3FYV X;  1RF7 A;  4PTJ A;  3F8Y A;  4XE6 X;  3QL0 A;  3FRF X;  4DP3 A;  2O7P A;  3QLR A;  3FRE X;  3GYF A;  1HFR A;  3I8A X;  4DDR A;  3F0Q X;  3UM5 A;  1DDR A;  1RX2 A;  3L3R A;  5DXV A;  3QLW A;  1DYJ A;  1LUD A;  4ELG A;  5CCC A;  3JWC A;  3K74 A;  3NZC X;  3UM6 A;  2CD2 A;  1DIS A;  2KGK A;  2ZZA A;  3NRR A;  3DAU A;  3FY8 X;  1RA2 A;  2B3Z A;  4KL9 A;  3NXY A;  1IA2 A;  4KAK A;  4PST A;  4TU5 X;  4PTH A;  4KM2 A;  1S3Y A;  1DRA A;  4ELB A;  3KGY A;  3DG8 A;  4P68 A;  3KJS A;  3JW5 A;  4M7U A;  5EAJ A;  4KY4 A;  4X5J A;  4Q0E A;  4KBN A;  1AI9 A;  3QLS A;  4KFJ A;  4OSG A;  3SRR X;  1KMS A;  5HPB A;  3DL6 A;  1DR1 A;  4XT8 A;  1DR3 A;  2P4G A;  3FQZ A;  1RG7 A;  1RA3 A;  4FGG A;  4XRB A;  4Q67 A;  1RA9 A;  1QZF A;  4HOG A;  3FRB X;  3FL9 A;  1PDB A;  3GHC A;  3EEL A;  1AO8 A;  1JOM A;  2H2Q A;  3DGA A;  3GHW A;  3FL8 A;  1E26 A;  2W3M A;  3CL9 A;  3KY8 A;  3IA5 A;  4ELH A;  4QI9 A;  4FHB A;  3SRS X;  3SA2 A;  1IA4 A;  1RB2 A;  5HT5 A;  3IRM A;  4M6L A;  3TQ8 A;  2OBC A;  5HUI A;  3F0U X;  4IXG X;  4NX6 A;  1RX8 A;  3D80 A;  1DYR A;  3FS6 A;  5FDA A;  4DPD A;  3E0B A;  3CLB A;  4KLX A;  4I13 A;  1DF7 A;  1DRE A;  3F0X X;  2DHF A;  3F91 A;  1OHJ A;  4IXF X;  1DR2 A;  1RC4 A;  3DRC A;  3QLY A;  4KEB A;  3FQV A;  1DRH A;  3F0V X;  4EIG A;  4QJC A;  4DFR A;  1VDR A;  4KJJ A;  1DYI A;  3GHV A;  4GH8 A;  5U27 A;  1HFP A;  2D5N A;  4OR7 A;  4H96 A;  3FRD X;  4PSS A;  4PDJ A;  4XEC X;  1CD2 A;  2JYB A;  3S7A A;  3ROA A;  2ANQ A;  2DRC A;  1LY3 A;  3S9U A;  2BLC A;  1M7A A;  5HSU A;  3FRA X;  4Q6A A;  4ECK A;  4I1N A;  1DHJ A;  1BOZ A;  4QLE A;  3CD2 A;  4P3R A;  1IA3 A;  3FQF A;  2L28 A;  4M2X A;  3SRU X;  3EEK A;  1DAJ A;  3CSE A;  5U26 A;  4QJZ D;  3EX8 A;  2BLA A;  4XT6 A;  4P66 A;  2XW7 A;  2FZJ A;  3S3V A;  3IX9 A;  5JA3 A;  4HOE A;  1M78 A;  1VJ3 A;  3NZ9 X;  3IRN A;  4KY8 A;  4XT7 A;  4G3M A;  3NXO A;  4LAE X;  4X5I A;  2QK8 A;  3JWK A;  2CIG A;  2BL9 A;  3INV A;  2W3V A;  3NZA X;  3EIG A;  3OAF A;  5HF0 X;  4KJL A;  2W9G A;  3F8Z A;  3SH2 A;  5HVB A;  3QLX A;  4XT5 A;  4KJK A;  4H95 A;  3DAT A;  2ITH A;  4LAG X;  1D1G A;  3RG9 A;  1MVS A;  3SA1 A;  1PD9 A;  2C2T A;  5ECX A;  5DFR A;  3UM8 A;  3SRW X;  5ECC A;  3JVX A;  1DR5 A;  1DR6 A;  4QLG A;  2W3B A;  3TD8 A;  1RA8 A;  2BLB A;  2W9T A;  3QLZ A;  4LAH X;  1RB3 A;  3GI2 A;  1AOE A;  4P3Q A;  1RX4 A;  4LEK X;  3NZB X;  8DFR A;  1U71 A;  4KNE A;  1SEJ A;  4M6K A;  4EIZ A;  1DR4 A;  3RO9 A;  1U70 A;  2G6V A;  2HM9 A;  1KLK A;  3I3R A;  3DL5 A;  2HXV A;  4Q0D A;  1DRF A;  1J3J A;  1YHO A;  2LF1 A;  5HF2 X;  1MVT A;  3N0H A;  1RX7 A;  3KFY A;  4NX7 A;  1DR7 A;  1TDR A;  3SAI A;  1RE7 A;  3NXR A;  4EJ1 A;  1DHI A;  4CD2 A;  3JTW A;  3JWF A;  3M08 A;  4G95 A;  2INQ A;  3FQO A;  1HFQ A;  3ZPG A;  2AZN A;  1S3V A;  2HQP A;  2GD9 A;  4M6J A;  3FY9 X;  1PD8 A;  1DG5 A;  3QYO A;  4EIL A;  3NXT A;  3K2H A;  1DG8 A;  5HVE A;  3F0S X;  1S3W A;  4IXE D;  3Q1H A;  2OIP A;  4H98 A;  3NU0 A;  3VCO A;  5HT4 A;  4ELE A;  1RX3 A;  3QFX A;  1DG7 A;  3M09 A;  1RX1 A;  5HSR A;  5E8Q A;  1BZF A;  4FGH A;  1DRB A;  3DFR A;  3R33 A;  1KMV A;  3FQ0 A;  4HOF A;  4X5F A;  3K45 A;  4HA7 A;  3TQB A;  2W9H A;  3EEJ A;  3NZD A;  5JG0 X;  2FZI A;  3NXX A; 
#chains in the Genus database with same CATH homology
 4G8Z X;  3TQA A;  2W3A A;  4ELF A;  1RX6 A;  4KM0 A;  6DFR A;  1DYH A;  3QYL A;  4M7V A;  4XT4 A;  5HI6 A;  3IRO A;  2FZH A;  3HBB A;  1DHF A;  4HA9 A;  3D84 X;  1DLR A;  3KJR A;  7DFR A;  1DIU A;  1ZDR A;  4KD7 A;  3OCH A;  4X5G A;  1RD7 A;  2W9S A;  1RX5 A;  3SRQ X;  1RX9 A;  3F0B X;  4X5H A;  3JWM A;  1IA1 A;  1M79 A;  3K47 A;  1DDS A;  5HQY A;  1DLS A;  2W3W A;  3FYW X;  4KYA A;  3SR5 X;  1RA1 A;  3SQY X;  1CZ3 A;  3IA4 A;  2ANO A;  4QLF A;  1JUV A;  1RH3 A;  3SGY A;  1OHK A;  1JOL A;  3FQC A;  3ZPC A;  3TQ9 A;  3LG4 A;  2C2S A;  4DPH A;  1S3U A;  4PSY A;  3QG2 A;  3NXV A;  1J3K A;  3QL3 A;  1J3I A;  4H97 A;  2D0K A;  3JSU A;  1LY4 A;  3NZ6 X;  3NTZ A;  3QGT A;  1U72 A;  5HQZ A;  3JW3 A;  3EEM A;  4QHV A;  4RGC A;  3HJ3 A;  5CC9 A;  3FYV X;  1RF7 A;  4PTJ A;  3F8Y A;  4XE6 X;  3QL0 A;  3FRF X;  4DP3 A;  2O7P A;  3QLR A;  3FRE X;  3GYF A;  1HFR A;  3I8A X;  4DDR A;  3F0Q X;  3UM5 A;  1DDR A;  1RX2 A;  3L3R A;  5DXV A;  3QLW A;  1DYJ A;  1LUD A;  4ELG A;  5CCC A;  3JWC A;  3K74 A;  3NZC X;  3UM6 A;  2CD2 A;  1DIS A;  2KGK A;  2ZZA A;  3NRR A;  3DAU A;  3FY8 X;  1RA2 A;  2B3Z A;  4KL9 A;  3NXY A;  1IA2 A;  4KAK A;  4PST A;  4TU5 X;  4PTH A;  4KM2 A;  1S3Y A;  1DRA A;  4ELB A;  3KGY A;  3DG8 A;  4P68 A;  3KJS A;  3JW5 A;  4M7U A;  5EAJ A;  4KY4 A;  4X5J A;  4Q0E A;  4KBN A;  1AI9 A;  3QLS A;  4KFJ A;  4OSG A;  3SRR X;  1KMS A;  5HPB A;  3DL6 A;  1DR1 A;  4XT8 A;  1DR3 A;  2P4G A;  3FQZ A;  1RG7 A;  1RA3 A;  4FGG A;  4XRB A;  4Q67 A;  1RA9 A;  1QZF A;  4HOG A;  3FRB X;  3FL9 A;  1PDB A;  3GHC A;  3EEL A;  1AO8 A;  1JOM A;  2H2Q A;  3DGA A;  3GHW A;  3FL8 A;  1E26 A;  2W3M A;  3CL9 A;  3KY8 A;  3IA5 A;  4ELH A;  4QI9 A;  4FHB A;  3SRS X;  3SA2 A;  1IA4 A;  1RB2 A;  5HT5 A;  3IRM A;  4M6L A;  3TQ8 A;  2OBC A;  5HUI A;  3F0U X;  4IXG X;  4NX6 A;  1RX8 A;  3D80 A;  1DYR A;  3FS6 A;  5FDA A;  4DPD A;  3E0B A;  3CLB A;  4KLX A;  4I13 A;  1DF7 A;  1DRE A;  3F0X X;  2DHF A;  3F91 A;  1OHJ A;  4IXF X;  1DR2 A;  1RC4 A;  3DRC A;  3QLY A;  4KEB A;  3FQV A;  1DRH A;  3F0V X;  4EIG A;  4QJC A;  4DFR A;  1VDR A;  4KJJ A;  1DYI A;  3GHV A;  4GH8 A;  5U27 A;  1HFP A;  2D5N A;  4OR7 A;  4H96 A;  3FRD X;  4PSS A;  4PDJ A;  4XEC X;  1CD2 A;  2JYB A;  3S7A A;  3ROA A;  2ANQ A;  2DRC A;  1LY3 A;  3S9U A;  2BLC A;  1M7A A;  5HSU A;  3FRA X;  4Q6A A;  4ECK A;  4I1N A;  1DHJ A;  1BOZ A;  4QLE A;  3CD2 A;  4P3R A;  1IA3 A;  3FQF A;  2L28 A;  4M2X A;  3SRU X;  3EEK A;  1DAJ A;  3CSE A;  5U26 A;  4QJZ D;  3EX8 A;  2BLA A;  4XT6 A;  4P66 A;  2XW7 A;  2FZJ A;  3S3V A;  3IX9 A;  5JA3 A;  4HOE A;  1M78 A;  1VJ3 A;  3NZ9 X;  3IRN A;  4KY8 A;  4XT7 A;  4G3M A;  3NXO A;  4LAE X;  4X5I A;  2QK8 A;  3JWK A;  2CIG A;  2BL9 A;  3INV A;  2W3V A;  3NZA X;  3EIG A;  3OAF A;  5HF0 X;  4KJL A;  2W9G A;  3F8Z A;  3SH2 A;  5HVB A;  3QLX A;  4XT5 A;  4KJK A;  4H95 A;  3DAT A;  2ITH A;  4LAG X;  1D1G A;  3RG9 A;  1MVS A;  3SA1 A;  1PD9 A;  2C2T A;  5ECX A;  5DFR A;  3UM8 A;  3SRW X;  5ECC A;  3JVX A;  1DR5 A;  1DR6 A;  4QLG A;  2W3B A;  3TD8 A;  1RA8 A;  2BLB A;  2W9T A;  3QLZ A;  4LAH X;  1RB3 A;  3GI2 A;  1AOE A;  4P3Q A;  1RX4 A;  4LEK X;  3NZB X;  8DFR A;  1U71 A;  4KNE A;  1SEJ A;  4M6K A;  4EIZ A;  1DR4 A;  3RO9 A;  1U70 A;  2G6V A;  2HM9 A;  1KLK A;  3I3R A;  3DL5 A;  2HXV A;  4Q0D A;  1DRF A;  1J3J A;  1YHO A;  2LF1 A;  5HF2 X;  1MVT A;  3N0H A;  1RX7 A;  3KFY A;  4NX7 A;  1DR7 A;  1TDR A;  3SAI A;  1RE7 A;  3NXR A;  4EJ1 A;  1DHI A;  4CD2 A;  3JTW A;  3JWF A;  3M08 A;  4G95 A;  2INQ A;  3FQO A;  1HFQ A;  3ZPG A;  2AZN A;  1S3V A;  2HQP A;  2GD9 A;  4M6J A;  3FY9 X;  1PD8 A;  1DG5 A;  3QYO A;  4EIL A;  3NXT A;  3K2H A;  1DG8 A;  5HVE A;  3F0S X;  1S3W A;  4IXE D;  3Q1H A;  2OIP A;  4H98 A;  3NU0 A;  3VCO A;  5HT4 A;  4ELE A;  1RX3 A;  3QFX A;  1DG7 A;  3M09 A;  1RX1 A;  5HSR A;  5E8Q A;  1BZF A;  4FGH A;  1DRB A;  3DFR A;  3R33 A;  1KMV A;  3FQ0 A;  4HOF A;  4X5F A;  3K45 A;  4HA7 A;  3TQB A;  2W9H A;  3EEJ A;  3NZD A;  5JG0 X;  2FZI A;  3NXX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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