1DRHA

Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 40
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1994-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1drhA00
2GD9A 4KY8A 3JW3A 1RA3A 4M2XA 5FDAA 1DRBA 3F0UX 3DGAA 3E0BA 3HJ3A 5ECXA 3GHWA 2ANOA 4QLEA 4ELBA 2HXVA 1DR6A 3SRRX 3FRBX 1QZFA 3FRDX 2D5NA 3DL5A 4OR7A 1DG5A 4LAHX 3FQCA 3DATA 3QLYA 3QYOA 5JG0X 1DG7A 3GI2A 4I13A 4EJ1A 4DDRA 5CC9A 1JOLA 1MVSA 2C2SA 1LUDA 1JUVA 4RGCA 5HF2X 1PD8A 5DFRA 4HOGA 1RX7A 4G8ZX 3M09A 4ELHA 3FYWX 3R33A 3FREX 1RB3A 3ROAA 2BLCA 5HF0X 4PTHA 4EIGA 1RX2A 4LAGX 3NZDA 4XT7A 4KLXA 2G6VA 1J3KA 4PDJA 3NZBX 4TU5X 3NU0A 2HM9A 1S3WA 2B3ZA 1OHKA 1DYJA 4HOFA 1OHJA 5HQYA 3IA4A 5ECCA 3ZPCA 3ZPGA 3NZ9X 4QLFA 3K47A 1RA8A 3SRWX 1RB2A 1DYHA 3NTZA 1HFRA 1DISA 2C2TA 3NRRA 1RA9A 2FZJA 4P3QA 1RX4A 1DYRA 3F0VX 3JW5A 4KYAA 4H95A 4IXGX 3SRUX 4H96A 4FHBA 1KLKA 4H97A 3DFRA 1DHJA 3S3VA 1IA3A 4DFRA 2W9HA 3Q1HA 4Q0DA 1S3YA 3CL9A 5HPBA 3HBBA 1RC4A 1RG7A 4KEBA 2W3AA 3CSEA 4OSGA 4X5IA 3TQ9A 3QLSA 4GH8A 2P4GA 4XE6X 3GHCA 3NXYA 3CD2A 4I1NA 3UM5A 3UM8A 3SRSX 3EELA 3F0SX 2DRCA 3NZ6X 5E8QA 3JWCA 1CD2A 1U71A 3KFYA 4G95A 3EIGA 3QLXA 1ZDRA 3QYLA 2DHFA 3DG8A 1DYIA 3TQ8A 4M6LA 3NXOA 1JOMA 2FZIA 2W3VA 3JWMA 2O7PA 2ZZAA 3QLRA 3TQAA 3NXRA 4M7UA 4XECX 4IXED 4KD7A 1IA1A 2ITHA 5HVBA 2W9TA 3EEMA 2W3MA 1MVTA 1U70A 3SRQX 4ELFA 3NXTA 1J3IA 4EIZA 3QG2A 3KY8A 3K2HA 4DPDA 3UM6A 3D80A 1LY3A 2BL9A 3F91A 3TD8A 3I8AX 3RO9A 1AI9A 3QLZA 1DRFA 1D1GA 3IRNA 5HSRA 4H98A 1DDRA 1DHIA 1YHOA 4HA7A 5DXVA 2LF1A 1U72A 1BOZA 4HA9A 4M6JA 1AOEA 4FGHA 4Q67A 4PSSA 3EEKA 1SEJA 2XW7A 3RG9A 4IXFX 3KJSA 1DREA 5EAJA 3F8YA 5U26A 2INQA 4P3RA 3N0HA 4X5GA 4P66A 1RA2A 3F8ZA 4ELEA 3EEJA 1RX8A 2OIPA 4Q0EA 1DLSA 4XRBA 5HI6A 1S3VA 3TQBA 3K45A 3OCHA 4QI9A 4G3MA 3F0XX 5HVEA 4KJLA 2BLAA 6DFRA 1M78A 5HSUA 1DG8A 3SQYX 3NXXA 1M7AA 3F0BX 5HQZA 3SH2A 2L28A 3FY8X 1RX3A 3IX9A 2QK8A 5JA3A 3OAFA 4NX6A 3GYFA 1DR1A 3L3RA 4KJJA 4EILA 4KM0A 4DP3A 3EX8A 1M79A 1DR3A 3JWKA 3QLWA 1RX6A 3M08A 3FYVX 4XT5A 1J3JA 3F0QX 4QJCA 1IA4A 4CD2A 1DRAA 1DLRA 8DFRA 4KL9A 3FQVA 3JWFA 4ECKA 3SAIA 3NZCX 3DRCA 3JSUA 2KGKA 3FL9A 5HT4A 5CCCA 3KJRA 1DIUA 3INVA 4ELGA 3CLBA 2HQPA 3SGYA 1IA2A 1RH3A 1RX9A 3NXVA 4X5FA 2D0KA 5HUIA 1BZFA 3SA2A 4KAKA 4LEKX 4KY4A 4FGGA 3QL3A 1DDSA 4KNEA 3I3RA 3VCOA 1TDRA 2FZHA 2W9GA 3S9UA 3DAUA 1RF7A 4Q6AA 3JVXA 1KMVA 2W3WA 3LG4A 3QGTA 1DR5A 1S3UA 4KM2A 1DR7A 3GHVA 4PTJA 4KBNA 1RD7A 4XT4A 3IRMA 3IROA 3QL0A 3FY9X 1LY4A 3D84X 4NX7A 3FQOA 1HFPA 1VJ3A 1DHFA 2CD2A 2CIGA 3FQZA 3FS6A 2ANQA 3NZAX 4QHVA 1RE7A 1RX5A 3FQ0A 1DRHA 1PDBA 2W9SA 4QLGA 1PD9A 1DAJA 3FL8A 4XT6A 1KMSA 4M6KA 4LAEX 4XT8A 3K74A 3DL6A 1RX1A 3SA1A 1AO8A 4HOEA 3KGYA 1HFQA 3QFXA 1DR2A 4M7VA 2OBCA 1DF7A 4KFJA 4X5JA 4PSYA 4DPHA 3IA5A 4KJKA 4QJZD 4PSTA 5HT5A 3S7AA 1DR4A 2BLBA 4P68A 7DFRA 3JTWA 5U27A 1VDRA 2W3BA 3SR5X 3FRAX 2JYBA 1RA1A 3FQFA 1CZ3A 2AZNA 4X5HA 3FRFX 1E26A 2H2QA
chains in the Genus database with same CATH superfamily
2GD9A 4KY8A 3JW3A 1RA3A 4M2XA 5FDAA 1DRBA 3F0UX 3DGAA 3E0BA 3HJ3A 5ECXA 3GHWA 2ANOA 4QLEA 4ELBA 2HXVA 1DR6A 3SRRX 3FRBX 1QZFA 3FRDX 2D5NA 3DL5A 4OR7A 1DG5A 4LAHX 3FQCA 3DATA 3QLYA 3QYOA 5JG0X 1DG7A 3GI2A 4I13A 4EJ1A 4DDRA 5CC9A 1JOLA 1MVSA 2C2SA 1LUDA 1JUVA 4RGCA 5HF2X 1PD8A 5DFRA 4HOGA 1RX7A 4G8ZX 3M09A 4ELHA 3FYWX 3R33A 3FREX 1RB3A 3ROAA 2BLCA 5HF0X 4PTHA 4EIGA 1RX2A 4LAGX 3NZDA 4XT7A 4KLXA 2G6VA 1J3KA 4PDJA 3NZBX 4TU5X 3NU0A 2HM9A 1S3WA 2B3ZA 1OHKA 1DYJA 4HOFA 1OHJA 5HQYA 3IA4A 5ECCA 3ZPCA 3ZPGA 3NZ9X 4QLFA 3K47A 1RA8A 3SRWX 1RB2A 1DYHA 3NTZA 1HFRA 1DISA 2C2TA 3NRRA 1RA9A 2FZJA 4P3QA 1RX4A 1DYRA 3F0VX 3JW5A 4KYAA 4H95A 4IXGX 3SRUX 4H96A 4FHBA 1KLKA 4H97A 3DFRA 1DHJA 3S3VA 1IA3A 4DFRA 2W9HA 3Q1HA 4Q0DA 1S3YA 3CL9A 5HPBA 3HBBA 1RC4A 1RG7A 4KEBA 2W3AA 3CSEA 4OSGA 4X5IA 3TQ9A 3QLSA 4GH8A 2P4GA 4XE6X 3GHCA 3NXYA 3CD2A 4I1NA 3UM5A 3UM8A 3SRSX 3EELA 3F0SX 2DRCA 3NZ6X 5E8QA 3JWCA 1CD2A 1U71A 3KFYA 4G95A 3EIGA 3QLXA 1ZDRA 3QYLA 2DHFA 3DG8A 1DYIA 3TQ8A 4M6LA 3NXOA 1JOMA 2FZIA 2W3VA 3JWMA 2O7PA 2ZZAA 3QLRA 3TQAA 3NXRA 4M7UA 4XECX 4IXED 4KD7A 1IA1A 2ITHA 5HVBA 2W9TA 3EEMA 2W3MA 1MVTA 1U70A 3SRQX 4ELFA 3NXTA 1J3IA 4EIZA 3QG2A 3KY8A 3K2HA 4DPDA 3UM6A 3D80A 1LY3A 2BL9A 3F91A 3TD8A 3I8AX 3RO9A 1AI9A 3QLZA 1DRFA 1D1GA 3IRNA 5HSRA 4H98A 1DDRA 1DHIA 1YHOA 4HA7A 5DXVA 2LF1A 1U72A 1BOZA 4HA9A 4M6JA 1AOEA 4FGHA 4Q67A 4PSSA 3EEKA 1SEJA 2XW7A 3RG9A 4IXFX 3KJSA 1DREA 5EAJA 3F8YA 5U26A 2INQA 4P3RA 3N0HA 4X5GA 4P66A 1RA2A 3F8ZA 4ELEA 3EEJA 1RX8A 2OIPA 4Q0EA 1DLSA 4XRBA 5HI6A 1S3VA 3TQBA 3K45A 3OCHA 4QI9A 4G3MA 3F0XX 5HVEA 4KJLA 2BLAA 6DFRA 1M78A 5HSUA 1DG8A 3SQYX 3NXXA 1M7AA 3F0BX 5HQZA 3SH2A 2L28A 3FY8X 1RX3A 3IX9A 2QK8A 5JA3A 3OAFA 4NX6A 3GYFA 1DR1A 3L3RA 4KJJA 4EILA 4KM0A 4DP3A 3EX8A 1M79A 1DR3A 3JWKA 3QLWA 1RX6A 3M08A 3FYVX 4XT5A 1J3JA 3F0QX 4QJCA 1IA4A 4CD2A 1DRAA 1DLRA 8DFRA 4KL9A 3FQVA 3JWFA 4ECKA 3SAIA 3NZCX 3DRCA 3JSUA 2KGKA 3FL9A 5HT4A 5CCCA 3KJRA 1DIUA 3INVA 4ELGA 3CLBA 2HQPA 3SGYA 1IA2A 1RH3A 1RX9A 3NXVA 4X5FA 2D0KA 5HUIA 1BZFA 3SA2A 4KAKA 4LEKX 4KY4A 4FGGA 3QL3A 1DDSA 4KNEA 3I3RA 3VCOA 1TDRA 2FZHA 2W9GA 3S9UA 3DAUA 1RF7A 4Q6AA 3JVXA 1KMVA 2W3WA 3LG4A 3QGTA 1DR5A 1S3UA 4KM2A 1DR7A 3GHVA 4PTJA 4KBNA 1RD7A 4XT4A 3IRMA 3IROA 3QL0A 3FY9X 1LY4A 3D84X 4NX7A 3FQOA 1HFPA 1VJ3A 1DHFA 2CD2A 2CIGA 3FQZA 3FS6A 2ANQA 3NZAX 4QHVA 1RE7A 1RX5A 3FQ0A 1DRHA 1PDBA 2W9SA 4QLGA 1PD9A 1DAJA 3FL8A 4XT6A 1KMSA 4M6KA 4LAEX 4XT8A 3K74A 3DL6A 1RX1A 3SA1A 1AO8A 4HOEA 3KGYA 1HFQA 3QFXA 1DR2A 4M7VA 2OBCA 1DF7A 4KFJA 4X5JA 4PSYA 4DPHA 3IA5A 4KJKA 4QJZD 4PSTA 5HT5A 3S7AA 1DR4A 2BLBA 4P68A 7DFRA 3JTWA 5U27A 1VDRA 2W3BA 3SR5X 3FRAX 2JYBA 1RA1A 3FQFA 1CZ3A 2AZNA 4X5HA 3FRFX 1E26A 2H2QA
chains in the Genus database with same CATH topology
2GD9A 4KY8A 3JW3A 1RA3A 4M2XA 5FDAA 1DRBA 3F0UX 3DGAA 3E0BA 3HJ3A 5ECXA 3GHWA 2ANOA 4QLEA 4ELBA 2HXVA 1DR6A 3SRRX 3FRBX 1QZFA 3FRDX 2D5NA 3DL5A 4OR7A 1DG5A 4LAHX 3FQCA 3DATA 3QLYA 3QYOA 5JG0X 1DG7A 3GI2A 4I13A 4EJ1A 4DDRA 5CC9A 1JOLA 1MVSA 2C2SA 1LUDA 1JUVA 4RGCA 5HF2X 1PD8A 5DFRA 4HOGA 1RX7A 4G8ZX 3M09A 4ELHA 3FYWX 3R33A 3FREX 1RB3A 3ROAA 2BLCA 5HF0X 4PTHA 4EIGA 1RX2A 4LAGX 3NZDA 4XT7A 4KLXA 2G6VA 1J3KA 4PDJA 3NZBX 4TU5X 3NU0A 2HM9A 1S3WA 2B3ZA 1OHKA 1DYJA 4HOFA 1OHJA 5HQYA 3IA4A 5ECCA 3ZPCA 3ZPGA 3NZ9X 4QLFA 3K47A 1RA8A 3SRWX 1RB2A 1DYHA 3NTZA 1HFRA 1DISA 2C2TA 3NRRA 1RA9A 2FZJA 4P3QA 1RX4A 1DYRA 3F0VX 3JW5A 4KYAA 4H95A 4IXGX 3SRUX 4H96A 4FHBA 1KLKA 4H97A 3DFRA 1DHJA 3S3VA 1IA3A 4DFRA 2W9HA 3Q1HA 4Q0DA 1S3YA 3CL9A 5HPBA 3HBBA 1RC4A 1RG7A 4KEBA 2W3AA 3CSEA 4OSGA 4X5IA 3TQ9A 3QLSA 4GH8A 2P4GA 4XE6X 3GHCA 3NXYA 3CD2A 4I1NA 3UM5A 3UM8A 3SRSX 3EELA 3F0SX 2DRCA 3NZ6X 5E8QA 3JWCA 1CD2A 1U71A 3KFYA 4G95A 3EIGA 3QLXA 1ZDRA 3QYLA 2DHFA 3DG8A 1DYIA 3TQ8A 4M6LA 3NXOA 1JOMA 2FZIA 2W3VA 3JWMA 2O7PA 2ZZAA 3QLRA 3TQAA 3NXRA 4M7UA 4XECX 4IXED 4KD7A 1IA1A 2ITHA 5HVBA 2W9TA 3EEMA 2W3MA 1MVTA 1U70A 3SRQX 4ELFA 3NXTA 1J3IA 4EIZA 3QG2A 3KY8A 3K2HA 4DPDA 3UM6A 3D80A 1LY3A 2BL9A 3F91A 3TD8A 3I8AX 3RO9A 1AI9A 3QLZA 1DRFA 1D1GA 3IRNA 5HSRA 4H98A 1DDRA 1DHIA 1YHOA 4HA7A 5DXVA 2LF1A 1U72A 1BOZA 4HA9A 4M6JA 1AOEA 4FGHA 4Q67A 4PSSA 3EEKA 1SEJA 2XW7A 3RG9A 4IXFX 3KJSA 1DREA 5EAJA 3F8YA 5U26A 2INQA 4P3RA 3N0HA 4X5GA 4P66A 1RA2A 3F8ZA 4ELEA 3EEJA 1RX8A 2OIPA 4Q0EA 1DLSA 4XRBA 5HI6A 1S3VA 3TQBA 3K45A 3OCHA 4QI9A 4G3MA 3F0XX 5HVEA 4KJLA 2BLAA 6DFRA 1M78A 5HSUA 1DG8A 3SQYX 3NXXA 1M7AA 3F0BX 5HQZA 3SH2A 2L28A 3FY8X 1RX3A 3IX9A 2QK8A 5JA3A 3OAFA 4NX6A 3GYFA 1DR1A 3L3RA 4KJJA 4EILA 4KM0A 4DP3A 3EX8A 1M79A 1DR3A 3JWKA 3QLWA 1RX6A 3M08A 3FYVX 4XT5A 1J3JA 3F0QX 4QJCA 1IA4A 4CD2A 1DRAA 1DLRA 8DFRA 4KL9A 3FQVA 3JWFA 4ECKA 3SAIA 3NZCX 3DRCA 3JSUA 2KGKA 3FL9A 5HT4A 5CCCA 3KJRA 1DIUA 3INVA 4ELGA 3CLBA 2HQPA 3SGYA 1IA2A 1RH3A 1RX9A 3NXVA 4X5FA 2D0KA 5HUIA 1BZFA 3SA2A 4KAKA 4LEKX 4KY4A 4FGGA 3QL3A 1DDSA 4KNEA 3I3RA 3VCOA 1TDRA 2FZHA 2W9GA 3S9UA 3DAUA 1RF7A 4Q6AA 3JVXA 1KMVA 2W3WA 3LG4A 3QGTA 1DR5A 1S3UA 4KM2A 1DR7A 3GHVA 4PTJA 4KBNA 1RD7A 4XT4A 3IRMA 3IROA 3QL0A 3FY9X 1LY4A 3D84X 4NX7A 3FQOA 1HFPA 1VJ3A 1DHFA 2CD2A 2CIGA 3FQZA 3FS6A 2ANQA 3NZAX 4QHVA 1RE7A 1RX5A 3FQ0A 1DRHA 1PDBA 2W9SA 4QLGA 1PD9A 1DAJA 3FL8A 4XT6A 1KMSA 4M6KA 4LAEX 4XT8A 3K74A 3DL6A 1RX1A 3SA1A 1AO8A 4HOEA 3KGYA 1HFQA 3QFXA 1DR2A 4M7VA 2OBCA 1DF7A 4KFJA 4X5JA 4PSYA 4DPHA 3IA5A 4KJKA 4QJZD 4PSTA 5HT5A 3S7AA 1DR4A 2BLBA 4P68A 7DFRA 3JTWA 5U27A 1VDRA 2W3BA 3SR5X 3FRAX 2JYBA 1RA1A 3FQFA 1CZ3A 2AZNA 4X5HA 3FRFX 1E26A 2H2QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GD9 A;  4KY8 A;  3JW3 A;  1RA3 A;  4M2X A;  5FDA A;  1DRB A;  3F0U X;  3DGA A;  3E0B A;  3HJ3 A;  5ECX A;  3GHW A;  2ANO A;  4QLE A;  4ELB A;  2HXV A;  1DR6 A;  3SRR X;  3FRB X;  1QZF A;  3FRD X;  2D5N A;  3DL5 A;  4OR7 A;  1DG5 A;  4LAH X;  3FQC A;  3DAT A;  3QLY A;  3QYO A;  5JG0 X;  1DG7 A;  3GI2 A;  4I13 A;  4EJ1 A;  4DDR A;  5CC9 A;  1JOL A;  1MVS A;  2C2S A;  1LUD A;  1JUV A;  4RGC A;  5HF2 X;  1PD8 A;  5DFR A;  4HOG A;  1RX7 A;  4G8Z X;  3M09 A;  4ELH A;  3FYW X;  3R33 A;  3FRE X;  1RB3 A;  3ROA A;  2BLC A;  5HF0 X;  4PTH A;  4EIG A;  1RX2 A;  4LAG X;  3NZD A;  4XT7 A;  4KLX A;  2G6V A;  1J3K A;  4PDJ A;  3NZB X;  4TU5 X;  3NU0 A;  2HM9 A;  1S3W A;  2B3Z A;  1OHK A;  1DYJ A;  4HOF A;  1OHJ A;  5HQY A;  3IA4 A;  5ECC A;  3ZPC A;  3ZPG A;  3NZ9 X;  4QLF A;  3K47 A;  1RA8 A;  3SRW X;  1RB2 A;  1DYH A;  3NTZ A;  1HFR A;  1DIS A;  2C2T A;  3NRR A;  1RA9 A;  2FZJ A;  4P3Q A;  1RX4 A;  1DYR A;  3F0V X;  3JW5 A;  4KYA A;  4H95 A;  4IXG X;  3SRU X;  4H96 A;  4FHB A;  1KLK A;  4H97 A;  3DFR A;  1DHJ A;  3S3V A;  1IA3 A;  4DFR A;  2W9H A;  3Q1H A;  4Q0D A;  1S3Y A;  3CL9 A;  5HPB A;  3HBB A;  1RC4 A;  1RG7 A;  4KEB A;  2W3A A;  3CSE A;  4OSG A;  4X5I A;  3TQ9 A;  3QLS A;  4GH8 A;  2P4G A;  4XE6 X;  3GHC A;  3NXY A;  3CD2 A;  4I1N A;  3UM5 A;  3UM8 A;  3SRS X;  3EEL A;  3F0S X;  2DRC A;  3NZ6 X;  5E8Q A;  3JWC A;  1CD2 A;  1U71 A;  3KFY A;  4G95 A;  3EIG A;  3QLX A;  1ZDR A;  3QYL A;  2DHF A;  3DG8 A;  1DYI A;  3TQ8 A;  4M6L A;  3NXO A;  1JOM A;  2FZI A;  2W3V A;  3JWM A;  2O7P A;  2ZZA A;  3QLR A;  3TQA A;  3NXR A;  4M7U A;  4XEC X;  4IXE D;  4KD7 A;  1IA1 A;  2ITH A;  5HVB A;  2W9T A;  3EEM A;  2W3M A;  1MVT A;  1U70 A;  3SRQ X;  4ELF A;  3NXT A;  1J3I A;  4EIZ A;  3QG2 A;  3KY8 A;  3K2H A;  4DPD A;  3UM6 A;  3D80 A;  1LY3 A;  2BL9 A;  3F91 A;  3TD8 A;  3I8A X;  3RO9 A;  1AI9 A;  3QLZ A;  1DRF A;  1D1G A;  3IRN A;  5HSR A;  4H98 A;  1DDR A;  1DHI A;  1YHO A;  4HA7 A;  5DXV A;  2LF1 A;  1U72 A;  1BOZ A;  4HA9 A;  4M6J A;  1AOE A;  4FGH A;  4Q67 A;  4PSS A;  3EEK A;  1SEJ A;  2XW7 A;  3RG9 A;  4IXF X;  3KJS A;  1DRE A;  5EAJ A;  3F8Y A;  5U26 A;  2INQ A;  4P3R A;  3N0H A;  4X5G A;  4P66 A;  1RA2 A;  3F8Z A;  4ELE A;  3EEJ A;  1RX8 A;  2OIP A;  4Q0E A;  1DLS A;  4XRB A;  5HI6 A;  1S3V A;  3TQB A;  3K45 A;  3OCH A;  4QI9 A;  4G3M A;  3F0X X;  5HVE A;  4KJL A;  2BLA A;  6DFR A;  1M78 A;  5HSU A;  1DG8 A;  3SQY X;  3NXX A;  1M7A A;  3F0B X;  5HQZ A;  3SH2 A;  2L28 A;  3FY8 X;  1RX3 A;  3IX9 A;  2QK8 A;  5JA3 A;  3OAF A;  4NX6 A;  3GYF A;  1DR1 A;  3L3R A;  4KJJ A;  4EIL A;  4KM0 A;  4DP3 A;  3EX8 A;  1M79 A;  1DR3 A;  3JWK A;  3QLW A;  1RX6 A;  3M08 A;  3FYV X;  4XT5 A;  1J3J A;  3F0Q X;  4QJC A;  1IA4 A;  4CD2 A;  1DRA A;  1DLR A;  8DFR A;  4KL9 A;  3FQV A;  3JWF A;  4ECK A;  3SAI A;  3NZC X;  3DRC A;  3JSU A;  2KGK A;  3FL9 A;  5HT4 A;  5CCC A;  3KJR A;  1DIU A;  3INV A;  4ELG A;  3CLB A;  2HQP A;  3SGY A;  1IA2 A;  1RH3 A;  1RX9 A;  3NXV A;  4X5F A;  2D0K A;  5HUI A;  1BZF A;  3SA2 A;  4KAK A;  4LEK X;  4KY4 A;  4FGG A;  3QL3 A;  1DDS A;  4KNE A;  3I3R A;  3VCO A;  1TDR A;  2FZH A;  2W9G A;  3S9U A;  3DAU A;  1RF7 A;  4Q6A A;  3JVX A;  1KMV A;  2W3W A;  3LG4 A;  3QGT A;  1DR5 A;  1S3U A;  4KM2 A;  1DR7 A;  3GHV A;  4PTJ A;  4KBN A;  1RD7 A;  4XT4 A;  3IRM A;  3IRO A;  3QL0 A;  3FY9 X;  1LY4 A;  3D84 X;  4NX7 A;  3FQO A;  1HFP A;  1VJ3 A;  1DHF A;  2CD2 A;  2CIG A;  3FQZ A;  3FS6 A;  2ANQ A;  3NZA X;  4QHV A;  1RE7 A;  1RX5 A;  3FQ0 A;  1DRH A;  1PDB A;  2W9S A;  4QLG A;  1PD9 A;  1DAJ A;  3FL8 A;  4XT6 A;  1KMS A;  4M6K A;  4LAE X;  4XT8 A;  3K74 A;  3DL6 A;  1RX1 A;  3SA1 A;  1AO8 A;  4HOE A;  3KGY A;  1HFQ A;  3QFX A;  1DR2 A;  4M7V A;  2OBC A;  1DF7 A;  4KFJ A;  4X5J A;  4PSY A;  4DPH A;  3IA5 A;  4KJK A;  4QJZ D;  4PST A;  5HT5 A;  3S7A A;  1DR4 A;  2BLB A;  4P68 A;  7DFR A;  3JTW A;  5U27 A;  1VDR A;  2W3B A;  3SR5 X;  3FRA X;  2JYB A;  1RA1 A;  3FQF A;  1CZ3 A;  2AZN A;  4X5H A;  3FRF X;  1E26 A;  2H2Q A; 
#chains in the Genus database with same CATH topology
 2GD9 A;  4KY8 A;  3JW3 A;  1RA3 A;  4M2X A;  5FDA A;  1DRB A;  3F0U X;  3DGA A;  3E0B A;  3HJ3 A;  5ECX A;  3GHW A;  2ANO A;  4QLE A;  4ELB A;  2HXV A;  1DR6 A;  3SRR X;  3FRB X;  1QZF A;  3FRD X;  2D5N A;  3DL5 A;  4OR7 A;  1DG5 A;  4LAH X;  3FQC A;  3DAT A;  3QLY A;  3QYO A;  5JG0 X;  1DG7 A;  3GI2 A;  4I13 A;  4EJ1 A;  4DDR A;  5CC9 A;  1JOL A;  1MVS A;  2C2S A;  1LUD A;  1JUV A;  4RGC A;  5HF2 X;  1PD8 A;  5DFR A;  4HOG A;  1RX7 A;  4G8Z X;  3M09 A;  4ELH A;  3FYW X;  3R33 A;  3FRE X;  1RB3 A;  3ROA A;  2BLC A;  5HF0 X;  4PTH A;  4EIG A;  1RX2 A;  4LAG X;  3NZD A;  4XT7 A;  4KLX A;  2G6V A;  1J3K A;  4PDJ A;  3NZB X;  4TU5 X;  3NU0 A;  2HM9 A;  1S3W A;  2B3Z A;  1OHK A;  1DYJ A;  4HOF A;  1OHJ A;  5HQY A;  3IA4 A;  5ECC A;  3ZPC A;  3ZPG A;  3NZ9 X;  4QLF A;  3K47 A;  1RA8 A;  3SRW X;  1RB2 A;  1DYH A;  3NTZ A;  1HFR A;  1DIS A;  2C2T A;  3NRR A;  1RA9 A;  2FZJ A;  4P3Q A;  1RX4 A;  1DYR A;  3F0V X;  3JW5 A;  4KYA A;  4H95 A;  4IXG X;  3SRU X;  4H96 A;  4FHB A;  1KLK A;  4H97 A;  3DFR A;  1DHJ A;  3S3V A;  1IA3 A;  4DFR A;  2W9H A;  3Q1H A;  4Q0D A;  1S3Y A;  3CL9 A;  5HPB A;  3HBB A;  1RC4 A;  1RG7 A;  4KEB A;  2W3A A;  3CSE A;  4OSG A;  4X5I A;  3TQ9 A;  3QLS A;  4GH8 A;  2P4G A;  4XE6 X;  3GHC A;  3NXY A;  3CD2 A;  4I1N A;  3UM5 A;  3UM8 A;  3SRS X;  3EEL A;  3F0S X;  2DRC A;  3NZ6 X;  5E8Q A;  3JWC A;  1CD2 A;  1U71 A;  3KFY A;  4G95 A;  3EIG A;  3QLX A;  1ZDR A;  3QYL A;  2DHF A;  3DG8 A;  1DYI A;  3TQ8 A;  4M6L A;  3NXO A;  1JOM A;  2FZI A;  2W3V A;  3JWM A;  2O7P A;  2ZZA A;  3QLR A;  3TQA A;  3NXR A;  4M7U A;  4XEC X;  4IXE D;  4KD7 A;  1IA1 A;  2ITH A;  5HVB A;  2W9T A;  3EEM A;  2W3M A;  1MVT A;  1U70 A;  3SRQ X;  4ELF A;  3NXT A;  1J3I A;  4EIZ A;  3QG2 A;  3KY8 A;  3K2H A;  4DPD A;  3UM6 A;  3D80 A;  1LY3 A;  2BL9 A;  3F91 A;  3TD8 A;  3I8A X;  3RO9 A;  1AI9 A;  3QLZ A;  1DRF A;  1D1G A;  3IRN A;  5HSR A;  4H98 A;  1DDR A;  1DHI A;  1YHO A;  4HA7 A;  5DXV A;  2LF1 A;  1U72 A;  1BOZ A;  4HA9 A;  4M6J A;  1AOE A;  4FGH A;  4Q67 A;  4PSS A;  3EEK A;  1SEJ A;  2XW7 A;  3RG9 A;  4IXF X;  3KJS A;  1DRE A;  5EAJ A;  3F8Y A;  5U26 A;  2INQ A;  4P3R A;  3N0H A;  4X5G A;  4P66 A;  1RA2 A;  3F8Z A;  4ELE A;  3EEJ A;  1RX8 A;  2OIP A;  4Q0E A;  1DLS A;  4XRB A;  5HI6 A;  1S3V A;  3TQB A;  3K45 A;  3OCH A;  4QI9 A;  4G3M A;  3F0X X;  5HVE A;  4KJL A;  2BLA A;  6DFR A;  1M78 A;  5HSU A;  1DG8 A;  3SQY X;  3NXX A;  1M7A A;  3F0B X;  5HQZ A;  3SH2 A;  2L28 A;  3FY8 X;  1RX3 A;  3IX9 A;  2QK8 A;  5JA3 A;  3OAF A;  4NX6 A;  3GYF A;  1DR1 A;  3L3R A;  4KJJ A;  4EIL A;  4KM0 A;  4DP3 A;  3EX8 A;  1M79 A;  1DR3 A;  3JWK A;  3QLW A;  1RX6 A;  3M08 A;  3FYV X;  4XT5 A;  1J3J A;  3F0Q X;  4QJC A;  1IA4 A;  4CD2 A;  1DRA A;  1DLR A;  8DFR A;  4KL9 A;  3FQV A;  3JWF A;  4ECK A;  3SAI A;  3NZC X;  3DRC A;  3JSU A;  2KGK A;  3FL9 A;  5HT4 A;  5CCC A;  3KJR A;  1DIU A;  3INV A;  4ELG A;  3CLB A;  2HQP A;  3SGY A;  1IA2 A;  1RH3 A;  1RX9 A;  3NXV A;  4X5F A;  2D0K A;  5HUI A;  1BZF A;  3SA2 A;  4KAK A;  4LEK X;  4KY4 A;  4FGG A;  3QL3 A;  1DDS A;  4KNE A;  3I3R A;  3VCO A;  1TDR A;  2FZH A;  2W9G A;  3S9U A;  3DAU A;  1RF7 A;  4Q6A A;  3JVX A;  1KMV A;  2W3W A;  3LG4 A;  3QGT A;  1DR5 A;  1S3U A;  4KM2 A;  1DR7 A;  3GHV A;  4PTJ A;  4KBN A;  1RD7 A;  4XT4 A;  3IRM A;  3IRO A;  3QL0 A;  3FY9 X;  1LY4 A;  3D84 X;  4NX7 A;  3FQO A;  1HFP A;  1VJ3 A;  1DHF A;  2CD2 A;  2CIG A;  3FQZ A;  3FS6 A;  2ANQ A;  3NZA X;  4QHV A;  1RE7 A;  1RX5 A;  3FQ0 A;  1DRH A;  1PDB A;  2W9S A;  4QLG A;  1PD9 A;  1DAJ A;  3FL8 A;  4XT6 A;  1KMS A;  4M6K A;  4LAE X;  4XT8 A;  3K74 A;  3DL6 A;  1RX1 A;  3SA1 A;  1AO8 A;  4HOE A;  3KGY A;  1HFQ A;  3QFX A;  1DR2 A;  4M7V A;  2OBC A;  1DF7 A;  4KFJ A;  4X5J A;  4PSY A;  4DPH A;  3IA5 A;  4KJK A;  4QJZ D;  4PST A;  5HT5 A;  3S7A A;  1DR4 A;  2BLB A;  4P68 A;  7DFR A;  3JTW A;  5U27 A;  1VDR A;  2W3B A;  3SR5 X;  3FRA X;  2JYB A;  1RA1 A;  3FQF A;  1CZ3 A;  2AZN A;  4X5H A;  3FRF X;  1E26 A;  2H2Q A; 
#chains in the Genus database with same CATH homology
 2GD9 A;  4KY8 A;  3JW3 A;  1RA3 A;  4M2X A;  5FDA A;  1DRB A;  3F0U X;  3DGA A;  3E0B A;  3HJ3 A;  5ECX A;  3GHW A;  2ANO A;  4QLE A;  4ELB A;  2HXV A;  1DR6 A;  3SRR X;  3FRB X;  1QZF A;  3FRD X;  2D5N A;  3DL5 A;  4OR7 A;  1DG5 A;  4LAH X;  3FQC A;  3DAT A;  3QLY A;  3QYO A;  5JG0 X;  1DG7 A;  3GI2 A;  4I13 A;  4EJ1 A;  4DDR A;  5CC9 A;  1JOL A;  1MVS A;  2C2S A;  1LUD A;  1JUV A;  4RGC A;  5HF2 X;  1PD8 A;  5DFR A;  4HOG A;  1RX7 A;  4G8Z X;  3M09 A;  4ELH A;  3FYW X;  3R33 A;  3FRE X;  1RB3 A;  3ROA A;  2BLC A;  5HF0 X;  4PTH A;  4EIG A;  1RX2 A;  4LAG X;  3NZD A;  4XT7 A;  4KLX A;  2G6V A;  1J3K A;  4PDJ A;  3NZB X;  4TU5 X;  3NU0 A;  2HM9 A;  1S3W A;  2B3Z A;  1OHK A;  1DYJ A;  4HOF A;  1OHJ A;  5HQY A;  3IA4 A;  5ECC A;  3ZPC A;  3ZPG A;  3NZ9 X;  4QLF A;  3K47 A;  1RA8 A;  3SRW X;  1RB2 A;  1DYH A;  3NTZ A;  1HFR A;  1DIS A;  2C2T A;  3NRR A;  1RA9 A;  2FZJ A;  4P3Q A;  1RX4 A;  1DYR A;  3F0V X;  3JW5 A;  4KYA A;  4H95 A;  4IXG X;  3SRU X;  4H96 A;  4FHB A;  1KLK A;  4H97 A;  3DFR A;  1DHJ A;  3S3V A;  1IA3 A;  4DFR A;  2W9H A;  3Q1H A;  4Q0D A;  1S3Y A;  3CL9 A;  5HPB A;  3HBB A;  1RC4 A;  1RG7 A;  4KEB A;  2W3A A;  3CSE A;  4OSG A;  4X5I A;  3TQ9 A;  3QLS A;  4GH8 A;  2P4G A;  4XE6 X;  3GHC A;  3NXY A;  3CD2 A;  4I1N A;  3UM5 A;  3UM8 A;  3SRS X;  3EEL A;  3F0S X;  2DRC A;  3NZ6 X;  5E8Q A;  3JWC A;  1CD2 A;  1U71 A;  3KFY A;  4G95 A;  3EIG A;  3QLX A;  1ZDR A;  3QYL A;  2DHF A;  3DG8 A;  1DYI A;  3TQ8 A;  4M6L A;  3NXO A;  1JOM A;  2FZI A;  2W3V A;  3JWM A;  2O7P A;  2ZZA A;  3QLR A;  3TQA A;  3NXR A;  4M7U A;  4XEC X;  4IXE D;  4KD7 A;  1IA1 A;  2ITH A;  5HVB A;  2W9T A;  3EEM A;  2W3M A;  1MVT A;  1U70 A;  3SRQ X;  4ELF A;  3NXT A;  1J3I A;  4EIZ A;  3QG2 A;  3KY8 A;  3K2H A;  4DPD A;  3UM6 A;  3D80 A;  1LY3 A;  2BL9 A;  3F91 A;  3TD8 A;  3I8A X;  3RO9 A;  1AI9 A;  3QLZ A;  1DRF A;  1D1G A;  3IRN A;  5HSR A;  4H98 A;  1DDR A;  1DHI A;  1YHO A;  4HA7 A;  5DXV A;  2LF1 A;  1U72 A;  1BOZ A;  4HA9 A;  4M6J A;  1AOE A;  4FGH A;  4Q67 A;  4PSS A;  3EEK A;  1SEJ A;  2XW7 A;  3RG9 A;  4IXF X;  3KJS A;  1DRE A;  5EAJ A;  3F8Y A;  5U26 A;  2INQ A;  4P3R A;  3N0H A;  4X5G A;  4P66 A;  1RA2 A;  3F8Z A;  4ELE A;  3EEJ A;  1RX8 A;  2OIP A;  4Q0E A;  1DLS A;  4XRB A;  5HI6 A;  1S3V A;  3TQB A;  3K45 A;  3OCH A;  4QI9 A;  4G3M A;  3F0X X;  5HVE A;  4KJL A;  2BLA A;  6DFR A;  1M78 A;  5HSU A;  1DG8 A;  3SQY X;  3NXX A;  1M7A A;  3F0B X;  5HQZ A;  3SH2 A;  2L28 A;  3FY8 X;  1RX3 A;  3IX9 A;  2QK8 A;  5JA3 A;  3OAF A;  4NX6 A;  3GYF A;  1DR1 A;  3L3R A;  4KJJ A;  4EIL A;  4KM0 A;  4DP3 A;  3EX8 A;  1M79 A;  1DR3 A;  3JWK A;  3QLW A;  1RX6 A;  3M08 A;  3FYV X;  4XT5 A;  1J3J A;  3F0Q X;  4QJC A;  1IA4 A;  4CD2 A;  1DRA A;  1DLR A;  8DFR A;  4KL9 A;  3FQV A;  3JWF A;  4ECK A;  3SAI A;  3NZC X;  3DRC A;  3JSU A;  2KGK A;  3FL9 A;  5HT4 A;  5CCC A;  3KJR A;  1DIU A;  3INV A;  4ELG A;  3CLB A;  2HQP A;  3SGY A;  1IA2 A;  1RH3 A;  1RX9 A;  3NXV A;  4X5F A;  2D0K A;  5HUI A;  1BZF A;  3SA2 A;  4KAK A;  4LEK X;  4KY4 A;  4FGG A;  3QL3 A;  1DDS A;  4KNE A;  3I3R A;  3VCO A;  1TDR A;  2FZH A;  2W9G A;  3S9U A;  3DAU A;  1RF7 A;  4Q6A A;  3JVX A;  1KMV A;  2W3W A;  3LG4 A;  3QGT A;  1DR5 A;  1S3U A;  4KM2 A;  1DR7 A;  3GHV A;  4PTJ A;  4KBN A;  1RD7 A;  4XT4 A;  3IRM A;  3IRO A;  3QL0 A;  3FY9 X;  1LY4 A;  3D84 X;  4NX7 A;  3FQO A;  1HFP A;  1VJ3 A;  1DHF A;  2CD2 A;  2CIG A;  3FQZ A;  3FS6 A;  2ANQ A;  3NZA X;  4QHV A;  1RE7 A;  1RX5 A;  3FQ0 A;  1DRH A;  1PDB A;  2W9S A;  4QLG A;  1PD9 A;  1DAJ A;  3FL8 A;  4XT6 A;  1KMS A;  4M6K A;  4LAE X;  4XT8 A;  3K74 A;  3DL6 A;  1RX1 A;  3SA1 A;  1AO8 A;  4HOE A;  3KGY A;  1HFQ A;  3QFX A;  1DR2 A;  4M7V A;  2OBC A;  1DF7 A;  4KFJ A;  4X5J A;  4PSY A;  4DPH A;  3IA5 A;  4KJK A;  4QJZ D;  4PST A;  5HT5 A;  3S7A A;  1DR4 A;  2BLB A;  4P68 A;  7DFR A;  3JTW A;  5U27 A;  1VDR A;  2W3B A;  3SR5 X;  3FRA X;  2JYB A;  1RA1 A;  3FQF A;  1CZ3 A;  2AZN A;  4X5H A;  3FRF X;  1E26 A;  2H2Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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