1E26A

Design, synthesis and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
205
structure length
205
Chain Sequence
NQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ligand-Induced Conformational Changes in the Crystal Structures of Pneumocystis Carinii Dihydrofolate Reductase Complexes with Folate and Nadp+
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Pneumocystis carinii
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 57
structure length 205
sequence length 205
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2000-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1e26A00
4X5GA 3F8ZA 3QFXA 1RX3A 1S3VA 3KFYA 1DR1A 5HSUA 2QK8A 5HUIA 3NXTA 4NX6A 3FQFA 3NXOA 4XE6X 4DDRA 1DF7A 5HT5A 1RB3A 3DRCA 3QG2A 2C2SA 1DR3A 1S3WA 3K47A 4P66A 1RA3A 3S9UA 1DR7A 4XT4A 3JWKA 3LG4A 3S3VA 2HXVA 1RB2A 4KLXA 4EJ1A 2W9GA 4EIZA 3CL9A 3KJRA 1JOLA 1RG7A 4HOGA 4KJJA 2FZIA 4PSYA 2D5NA 3QLYA 4KM0A 3SA1A 1KMSA 1AO8A 3SH2A 2H2QA 3UM8A 3FRFX 3L3RA 7DFRA 1DG8A 3FS6A 3KGYA 1U72A 2O7PA 4G3MA 3EIGA 3KJSA 1RF7A 4H97A 1J3IA 1RX5A 3DATA 4PTJA 5HQYA 3JWFA 1TDRA 2ANQA 1E26A 1CD2A 3Q1HA 5HQZA 3FQ0A 3F0QX 4ELFA 1BOZA 3FRAX 1RA2A 3NZBX 4Q0EA 3HJ3A 3NXYA 3N0HA 1RC4A 1RX7A 2ZZAA 5ECXA 5CC9A 3QYLA 3QL0A 1RH3A 4ECKA 1DR2A 5HSRA 4QHVA 1VDRA 2XW7A 3FYVX 3QLWA 4H96A 1RA8A 3FY8X 1DIUA 3IA5A 1LY4A 2KGKA 3JW5A 5HPBA 1DYRA 3F0UX 3FQCA 3FRBX 3F0VX 1J3KA 1QZFA 3IRNA 3K45A 8DFRA 4G8ZX 1DDRA 2ANOA 1DG5A 3SAIA 3QLZA 1MVTA 3RG9A 3E0BA 1PD8A 1DRHA 3SR5X 1DR4A 3FL9A 1RD7A 4H95A 1RX1A 3D84X 2W3AA 5HT4A 4HOFA 4FHBA 1JOMA 2CD2A 5HVEA 3JWCA 4PTHA 5EAJA 4M7VA 3NZAX 3ZPGA 3R33A 4H98A 2CIGA 4KJKA 1SEJA 3EX8A 1KLKA 4FGGA 4LAHX 5U27A 5FDAA 3ROAA 1U71A 1DHFA 4KBNA 3NZ9X 3SRQX 2ITHA 1PDBA 1DRFA 3GYFA 1DHIA 1HFQA 4OR7A 4M6JA 3EEKA 4HA9A 3TQBA 5DXVA 1IA1A 3M09A 3FY9X 3SQYX 1KMVA 3SRUX 3I8AX 3CSEA 1LY3A 2BLBA 4LAEX 1DREA 4TU5X 2INQA 4XT6A 5JA3A 4KAKA 4CD2A 2G6VA 4DPHA 4X5IA 3JTWA 3IA4A 3QL3A 1M7AA 1OHKA 1S3UA 3GHWA 4Q67A 3FL8A 3FYWX 3ZPCA 2P4GA 5HVBA 4HA7A 1DYJA 4ELGA 4QJCA 3F91A 3F0BX 4X5FA 4KFJA 3I3RA 3NU0A 4X5HA 1OHJA 3VCOA 4KD7A 4M6LA 4P68A 1PD9A 3GI2A 5E8QA 1DYIA 4QI9A 4KY8A 2FZJA 3UM6A 3EEJA 5ECCA 1DRAA 4Q0DA 1YHOA 4DPDA 1DRBA 3RO9A 1DISA 2BLAA 3F8YA 1IA3A 3NZCX 4I13A 4XT7A 2DHFA 4DP3A 3NZDA 4KEBA 3QLSA 1DHJA 3INVA 3JWMA 1BZFA 4PDJA 4QJZD 5HF0X 3TQAA 3EEMA 4ELEA 1MVSA 2D0KA 3M08A 1CZ3A 3EELA 3CD2A 5HI6A 4EILA 1RX2A 4M7UA 3OAFA 3K74A 3DL6A 2HM9A 4KY4A 3NTZA 3KY8A 4KYAA 3IX9A 1RA1A 1DAJA 5HF2X 2W9HA 3IROA 3QLRA 3FREX 4G95A 3DG8A 3FQZA 2W9SA 2AZNA 4QLEA 1RX6A 4QLGA 4P3RA 3IRMA 4M2XA 1VJ3A 1DLRA 1M79A 4OSGA 1HFPA 3TD8A 5DFRA 4ELBA 4DFRA 4IXGX 2DRCA 3SRWX 1LUDA 1DYHA 3DFRA 5U26A 3F0SX 2W3BA 4EIGA 1AOEA 3NRRA 3OCHA 3FRDX 3NZ6X 3NXXA 4KL9A 3GHVA 2LF1A 3TQ8A 1AI9A 3SRRX 1IA2A 4XT5A 3DL5A 4I1NA 3JW3A 4GH8A 4LAGX 2L28A 2BL9A 3DAUA 3JVXA 3D80A 1RA9A 4ELHA 1RX9A 3UM5A 1HFRA 1J3JA 1RX8A 3SA2A 1RE7A 3NXRA 1S3YA 1U70A 2FZHA 4KJLA 5JG0X 3F0XX 1IA4A 4XT8A 4P3QA 3DGAA 4KM2A 2W3VA 4QLFA 4LEKX 4HOEA 3JSUA 4X5JA 4IXED 6DFRA 4FGHA 2W3MA 3QGTA 2GD9A 4M6KA 4NX7A 4XRBA 4KNEA 3CLBA 3SGYA 1DR6A 1D1GA 4IXFX 4RGCA 2C2TA 4XECX 3SRSX 3GHCA 3S7AA 1JUVA 5CCCA 3QLXA 3FQVA 1M78A 4PSTA 3HBBA 3TQ9A 1DDSA 2B3ZA 3NXVA 2OBCA 1DR5A 1RX4A 1DG7A 1ZDRA 2BLCA 4Q6AA 2JYBA 3QYOA 1DLSA 2W3WA 2W9TA 3FQOA 4PSSA 2HQPA 3K2HA 2OIPA
chains in the Genus database with same CATH superfamily
4X5GA 3F8ZA 3QFXA 1RX3A 1S3VA 3KFYA 1DR1A 5HSUA 2QK8A 5HUIA 3NXTA 4NX6A 3FQFA 3NXOA 4XE6X 4DDRA 1DF7A 5HT5A 1RB3A 3DRCA 3QG2A 2C2SA 1DR3A 1S3WA 3K47A 4P66A 1RA3A 3S9UA 1DR7A 4XT4A 3JWKA 3LG4A 3S3VA 2HXVA 1RB2A 4KLXA 4EJ1A 2W9GA 4EIZA 3CL9A 3KJRA 1JOLA 1RG7A 4HOGA 4KJJA 2FZIA 4PSYA 2D5NA 3QLYA 4KM0A 3SA1A 1KMSA 1AO8A 3SH2A 2H2QA 3UM8A 3FRFX 3L3RA 7DFRA 1DG8A 3FS6A 3KGYA 1U72A 2O7PA 4G3MA 3EIGA 3KJSA 1RF7A 4H97A 1J3IA 1RX5A 3DATA 4PTJA 5HQYA 3JWFA 1TDRA 2ANQA 1E26A 1CD2A 3Q1HA 5HQZA 3FQ0A 3F0QX 4ELFA 1BOZA 3FRAX 1RA2A 3NZBX 4Q0EA 3HJ3A 3NXYA 3N0HA 1RC4A 1RX7A 2ZZAA 5ECXA 5CC9A 3QYLA 3QL0A 1RH3A 4ECKA 1DR2A 5HSRA 4QHVA 1VDRA 2XW7A 3FYVX 3QLWA 4H96A 1RA8A 3FY8X 1DIUA 3IA5A 1LY4A 2KGKA 3JW5A 5HPBA 1DYRA 3F0UX 3FQCA 3FRBX 3F0VX 1J3KA 1QZFA 3IRNA 3K45A 8DFRA 4G8ZX 1DDRA 2ANOA 1DG5A 3SAIA 3QLZA 1MVTA 3RG9A 3E0BA 1PD8A 1DRHA 3SR5X 1DR4A 3FL9A 1RD7A 4H95A 1RX1A 3D84X 2W3AA 5HT4A 4HOFA 4FHBA 1JOMA 2CD2A 5HVEA 3JWCA 4PTHA 5EAJA 4M7VA 3NZAX 3ZPGA 3R33A 4H98A 2CIGA 4KJKA 1SEJA 3EX8A 1KLKA 4FGGA 4LAHX 5U27A 5FDAA 3ROAA 1U71A 1DHFA 4KBNA 3NZ9X 3SRQX 2ITHA 1PDBA 1DRFA 3GYFA 1DHIA 1HFQA 4OR7A 4M6JA 3EEKA 4HA9A 3TQBA 5DXVA 1IA1A 3M09A 3FY9X 3SQYX 1KMVA 3SRUX 3I8AX 3CSEA 1LY3A 2BLBA 4LAEX 1DREA 4TU5X 2INQA 4XT6A 5JA3A 4KAKA 4CD2A 2G6VA 4DPHA 4X5IA 3JTWA 3IA4A 3QL3A 1M7AA 1OHKA 1S3UA 3GHWA 4Q67A 3FL8A 3FYWX 3ZPCA 2P4GA 5HVBA 4HA7A 1DYJA 4ELGA 4QJCA 3F91A 3F0BX 4X5FA 4KFJA 3I3RA 3NU0A 4X5HA 1OHJA 3VCOA 4KD7A 4M6LA 4P68A 1PD9A 3GI2A 5E8QA 1DYIA 4QI9A 4KY8A 2FZJA 3UM6A 3EEJA 5ECCA 1DRAA 4Q0DA 1YHOA 4DPDA 1DRBA 3RO9A 1DISA 2BLAA 3F8YA 1IA3A 3NZCX 4I13A 4XT7A 2DHFA 4DP3A 3NZDA 4KEBA 3QLSA 1DHJA 3INVA 3JWMA 1BZFA 4PDJA 4QJZD 5HF0X 3TQAA 3EEMA 4ELEA 1MVSA 2D0KA 3M08A 1CZ3A 3EELA 3CD2A 5HI6A 4EILA 1RX2A 4M7UA 3OAFA 3K74A 3DL6A 2HM9A 4KY4A 3NTZA 3KY8A 4KYAA 3IX9A 1RA1A 1DAJA 5HF2X 2W9HA 3IROA 3QLRA 3FREX 4G95A 3DG8A 3FQZA 2W9SA 2AZNA 4QLEA 1RX6A 4QLGA 4P3RA 3IRMA 4M2XA 1VJ3A 1DLRA 1M79A 4OSGA 1HFPA 3TD8A 5DFRA 4ELBA 4DFRA 4IXGX 2DRCA 3SRWX 1LUDA 1DYHA 3DFRA 5U26A 3F0SX 2W3BA 4EIGA 1AOEA 3NRRA 3OCHA 3FRDX 3NZ6X 3NXXA 4KL9A 3GHVA 2LF1A 3TQ8A 1AI9A 3SRRX 1IA2A 4XT5A 3DL5A 4I1NA 3JW3A 4GH8A 4LAGX 2L28A 2BL9A 3DAUA 3JVXA 3D80A 1RA9A 4ELHA 1RX9A 3UM5A 1HFRA 1J3JA 1RX8A 3SA2A 1RE7A 3NXRA 1S3YA 1U70A 2FZHA 4KJLA 5JG0X 3F0XX 1IA4A 4XT8A 4P3QA 3DGAA 4KM2A 2W3VA 4QLFA 4LEKX 4HOEA 3JSUA 4X5JA 4IXED 6DFRA 4FGHA 2W3MA 3QGTA 2GD9A 4M6KA 4NX7A 4XRBA 4KNEA 3CLBA 3SGYA 1DR6A 1D1GA 4IXFX 4RGCA 2C2TA 4XECX 3SRSX 3GHCA 3S7AA 1JUVA 5CCCA 3QLXA 3FQVA 1M78A 4PSTA 3HBBA 3TQ9A 1DDSA 2B3ZA 3NXVA 2OBCA 1DR5A 1RX4A 1DG7A 1ZDRA 2BLCA 4Q6AA 2JYBA 3QYOA 1DLSA 2W3WA 2W9TA 3FQOA 4PSSA 2HQPA 3K2HA 2OIPA
chains in the Genus database with same CATH topology
4X5GA 3F8ZA 3QFXA 1RX3A 1S3VA 3KFYA 1DR1A 5HSUA 2QK8A 5HUIA 3NXTA 4NX6A 3FQFA 3NXOA 4XE6X 4DDRA 1DF7A 5HT5A 1RB3A 3DRCA 3QG2A 2C2SA 1DR3A 1S3WA 3K47A 4P66A 1RA3A 3S9UA 1DR7A 4XT4A 3JWKA 3LG4A 3S3VA 2HXVA 1RB2A 4KLXA 4EJ1A 2W9GA 4EIZA 3CL9A 3KJRA 1JOLA 1RG7A 4HOGA 4KJJA 2FZIA 4PSYA 2D5NA 3QLYA 4KM0A 3SA1A 1KMSA 1AO8A 3SH2A 2H2QA 3UM8A 3FRFX 3L3RA 7DFRA 1DG8A 3FS6A 3KGYA 1U72A 2O7PA 4G3MA 3EIGA 3KJSA 1RF7A 4H97A 1J3IA 1RX5A 3DATA 4PTJA 5HQYA 3JWFA 1TDRA 2ANQA 1E26A 1CD2A 3Q1HA 5HQZA 3FQ0A 3F0QX 4ELFA 1BOZA 3FRAX 1RA2A 3NZBX 4Q0EA 3HJ3A 3NXYA 3N0HA 1RC4A 1RX7A 2ZZAA 5ECXA 5CC9A 3QYLA 3QL0A 1RH3A 4ECKA 1DR2A 5HSRA 4QHVA 1VDRA 2XW7A 3FYVX 3QLWA 4H96A 1RA8A 3FY8X 1DIUA 3IA5A 1LY4A 2KGKA 3JW5A 5HPBA 1DYRA 3F0UX 3FQCA 3FRBX 3F0VX 1J3KA 1QZFA 3IRNA 3K45A 8DFRA 4G8ZX 1DDRA 2ANOA 1DG5A 3SAIA 3QLZA 1MVTA 3RG9A 3E0BA 1PD8A 1DRHA 3SR5X 1DR4A 3FL9A 1RD7A 4H95A 1RX1A 3D84X 2W3AA 5HT4A 4HOFA 4FHBA 1JOMA 2CD2A 5HVEA 3JWCA 4PTHA 5EAJA 4M7VA 3NZAX 3ZPGA 3R33A 4H98A 2CIGA 4KJKA 1SEJA 3EX8A 1KLKA 4FGGA 4LAHX 5U27A 5FDAA 3ROAA 1U71A 1DHFA 4KBNA 3NZ9X 3SRQX 2ITHA 1PDBA 1DRFA 3GYFA 1DHIA 1HFQA 4OR7A 4M6JA 3EEKA 4HA9A 3TQBA 5DXVA 1IA1A 3M09A 3FY9X 3SQYX 1KMVA 3SRUX 3I8AX 3CSEA 1LY3A 2BLBA 4LAEX 1DREA 4TU5X 2INQA 4XT6A 5JA3A 4KAKA 4CD2A 2G6VA 4DPHA 4X5IA 3JTWA 3IA4A 3QL3A 1M7AA 1OHKA 1S3UA 3GHWA 4Q67A 3FL8A 3FYWX 3ZPCA 2P4GA 5HVBA 4HA7A 1DYJA 4ELGA 4QJCA 3F91A 3F0BX 4X5FA 4KFJA 3I3RA 3NU0A 4X5HA 1OHJA 3VCOA 4KD7A 4M6LA 4P68A 1PD9A 3GI2A 5E8QA 1DYIA 4QI9A 4KY8A 2FZJA 3UM6A 3EEJA 5ECCA 1DRAA 4Q0DA 1YHOA 4DPDA 1DRBA 3RO9A 1DISA 2BLAA 3F8YA 1IA3A 3NZCX 4I13A 4XT7A 2DHFA 4DP3A 3NZDA 4KEBA 3QLSA 1DHJA 3INVA 3JWMA 1BZFA 4PDJA 4QJZD 5HF0X 3TQAA 3EEMA 4ELEA 1MVSA 2D0KA 3M08A 1CZ3A 3EELA 3CD2A 5HI6A 4EILA 1RX2A 4M7UA 3OAFA 3K74A 3DL6A 2HM9A 4KY4A 3NTZA 3KY8A 4KYAA 3IX9A 1RA1A 1DAJA 5HF2X 2W9HA 3IROA 3QLRA 3FREX 4G95A 3DG8A 3FQZA 2W9SA 2AZNA 4QLEA 1RX6A 4QLGA 4P3RA 3IRMA 4M2XA 1VJ3A 1DLRA 1M79A 4OSGA 1HFPA 3TD8A 5DFRA 4ELBA 4DFRA 4IXGX 2DRCA 3SRWX 1LUDA 1DYHA 3DFRA 5U26A 3F0SX 2W3BA 4EIGA 1AOEA 3NRRA 3OCHA 3FRDX 3NZ6X 3NXXA 4KL9A 3GHVA 2LF1A 3TQ8A 1AI9A 3SRRX 1IA2A 4XT5A 3DL5A 4I1NA 3JW3A 4GH8A 4LAGX 2L28A 2BL9A 3DAUA 3JVXA 3D80A 1RA9A 4ELHA 1RX9A 3UM5A 1HFRA 1J3JA 1RX8A 3SA2A 1RE7A 3NXRA 1S3YA 1U70A 2FZHA 4KJLA 5JG0X 3F0XX 1IA4A 4XT8A 4P3QA 3DGAA 4KM2A 2W3VA 4QLFA 4LEKX 4HOEA 3JSUA 4X5JA 4IXED 6DFRA 4FGHA 2W3MA 3QGTA 2GD9A 4M6KA 4NX7A 4XRBA 4KNEA 3CLBA 3SGYA 1DR6A 1D1GA 4IXFX 4RGCA 2C2TA 4XECX 3SRSX 3GHCA 3S7AA 1JUVA 5CCCA 3QLXA 3FQVA 1M78A 4PSTA 3HBBA 3TQ9A 1DDSA 2B3ZA 3NXVA 2OBCA 1DR5A 1RX4A 1DG7A 1ZDRA 2BLCA 4Q6AA 2JYBA 3QYOA 1DLSA 2W3WA 2W9TA 3FQOA 4PSSA 2HQPA 3K2HA 2OIPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X5G A;  3F8Z A;  3QFX A;  1RX3 A;  1S3V A;  3KFY A;  1DR1 A;  5HSU A;  2QK8 A;  5HUI A;  3NXT A;  4NX6 A;  3FQF A;  3NXO A;  4XE6 X;  4DDR A;  1DF7 A;  5HT5 A;  1RB3 A;  3DRC A;  3QG2 A;  2C2S A;  1DR3 A;  1S3W A;  3K47 A;  4P66 A;  1RA3 A;  3S9U A;  1DR7 A;  4XT4 A;  3JWK A;  3LG4 A;  3S3V A;  2HXV A;  1RB2 A;  4KLX A;  4EJ1 A;  2W9G A;  4EIZ A;  3CL9 A;  3KJR A;  1JOL A;  1RG7 A;  4HOG A;  4KJJ A;  2FZI A;  4PSY A;  2D5N A;  3QLY A;  4KM0 A;  3SA1 A;  1KMS A;  1AO8 A;  3SH2 A;  2H2Q A;  3UM8 A;  3FRF X;  3L3R A;  7DFR A;  1DG8 A;  3FS6 A;  3KGY A;  1U72 A;  2O7P A;  4G3M A;  3EIG A;  3KJS A;  1RF7 A;  4H97 A;  1J3I A;  1RX5 A;  3DAT A;  4PTJ A;  5HQY A;  3JWF A;  1TDR A;  2ANQ A;  1E26 A;  1CD2 A;  3Q1H A;  5HQZ A;  3FQ0 A;  3F0Q X;  4ELF A;  1BOZ A;  3FRA X;  1RA2 A;  3NZB X;  4Q0E A;  3HJ3 A;  3NXY A;  3N0H A;  1RC4 A;  1RX7 A;  2ZZA A;  5ECX A;  5CC9 A;  3QYL A;  3QL0 A;  1RH3 A;  4ECK A;  1DR2 A;  5HSR A;  4QHV A;  1VDR A;  2XW7 A;  3FYV X;  3QLW A;  4H96 A;  1RA8 A;  3FY8 X;  1DIU A;  3IA5 A;  1LY4 A;  2KGK A;  3JW5 A;  5HPB A;  1DYR A;  3F0U X;  3FQC A;  3FRB X;  3F0V X;  1J3K A;  1QZF A;  3IRN A;  3K45 A;  8DFR A;  4G8Z X;  1DDR A;  2ANO A;  1DG5 A;  3SAI A;  3QLZ A;  1MVT A;  3RG9 A;  3E0B A;  1PD8 A;  1DRH A;  3SR5 X;  1DR4 A;  3FL9 A;  1RD7 A;  4H95 A;  1RX1 A;  3D84 X;  2W3A A;  5HT4 A;  4HOF A;  4FHB A;  1JOM A;  2CD2 A;  5HVE A;  3JWC A;  4PTH A;  5EAJ A;  4M7V A;  3NZA X;  3ZPG A;  3R33 A;  4H98 A;  2CIG A;  4KJK A;  1SEJ A;  3EX8 A;  1KLK A;  4FGG A;  4LAH X;  5U27 A;  5FDA A;  3ROA A;  1U71 A;  1DHF A;  4KBN A;  3NZ9 X;  3SRQ X;  2ITH A;  1PDB A;  1DRF A;  3GYF A;  1DHI A;  1HFQ A;  4OR7 A;  4M6J A;  3EEK A;  4HA9 A;  3TQB A;  5DXV A;  1IA1 A;  3M09 A;  3FY9 X;  3SQY X;  1KMV A;  3SRU X;  3I8A X;  3CSE A;  1LY3 A;  2BLB A;  4LAE X;  1DRE A;  4TU5 X;  2INQ A;  4XT6 A;  5JA3 A;  4KAK A;  4CD2 A;  2G6V A;  4DPH A;  4X5I A;  3JTW A;  3IA4 A;  3QL3 A;  1M7A A;  1OHK A;  1S3U A;  3GHW A;  4Q67 A;  3FL8 A;  3FYW X;  3ZPC A;  2P4G A;  5HVB A;  4HA7 A;  1DYJ A;  4ELG A;  4QJC A;  3F91 A;  3F0B X;  4X5F A;  4KFJ A;  3I3R A;  3NU0 A;  4X5H A;  1OHJ A;  3VCO A;  4KD7 A;  4M6L A;  4P68 A;  1PD9 A;  3GI2 A;  5E8Q A;  1DYI A;  4QI9 A;  4KY8 A;  2FZJ A;  3UM6 A;  3EEJ A;  5ECC A;  1DRA A;  4Q0D A;  1YHO A;  4DPD A;  1DRB A;  3RO9 A;  1DIS A;  2BLA A;  3F8Y A;  1IA3 A;  3NZC X;  4I13 A;  4XT7 A;  2DHF A;  4DP3 A;  3NZD A;  4KEB A;  3QLS A;  1DHJ A;  3INV A;  3JWM A;  1BZF A;  4PDJ A;  4QJZ D;  5HF0 X;  3TQA A;  3EEM A;  4ELE A;  1MVS A;  2D0K A;  3M08 A;  1CZ3 A;  3EEL A;  3CD2 A;  5HI6 A;  4EIL A;  1RX2 A;  4M7U A;  3OAF A;  3K74 A;  3DL6 A;  2HM9 A;  4KY4 A;  3NTZ A;  3KY8 A;  4KYA A;  3IX9 A;  1RA1 A;  1DAJ A;  5HF2 X;  2W9H A;  3IRO A;  3QLR A;  3FRE X;  4G95 A;  3DG8 A;  3FQZ A;  2W9S A;  2AZN A;  4QLE A;  1RX6 A;  4QLG A;  4P3R A;  3IRM A;  4M2X A;  1VJ3 A;  1DLR A;  1M79 A;  4OSG A;  1HFP A;  3TD8 A;  5DFR A;  4ELB A;  4DFR A;  4IXG X;  2DRC A;  3SRW X;  1LUD A;  1DYH A;  3DFR A;  5U26 A;  3F0S X;  2W3B A;  4EIG A;  1AOE A;  3NRR A;  3OCH A;  3FRD X;  3NZ6 X;  3NXX A;  4KL9 A;  3GHV A;  2LF1 A;  3TQ8 A;  1AI9 A;  3SRR X;  1IA2 A;  4XT5 A;  3DL5 A;  4I1N A;  3JW3 A;  4GH8 A;  4LAG X;  2L28 A;  2BL9 A;  3DAU A;  3JVX A;  3D80 A;  1RA9 A;  4ELH A;  1RX9 A;  3UM5 A;  1HFR A;  1J3J A;  1RX8 A;  3SA2 A;  1RE7 A;  3NXR A;  1S3Y A;  1U70 A;  2FZH A;  4KJL A;  5JG0 X;  3F0X X;  1IA4 A;  4XT8 A;  4P3Q A;  3DGA A;  4KM2 A;  2W3V A;  4QLF A;  4LEK X;  4HOE A;  3JSU A;  4X5J A;  4IXE D;  6DFR A;  4FGH A;  2W3M A;  3QGT A;  2GD9 A;  4M6K A;  4NX7 A;  4XRB A;  4KNE A;  3CLB A;  3SGY A;  1DR6 A;  1D1G A;  4IXF X;  4RGC A;  2C2T A;  4XEC X;  3SRS X;  3GHC A;  3S7A A;  1JUV A;  5CCC A;  3QLX A;  3FQV A;  1M78 A;  4PST A;  3HBB A;  3TQ9 A;  1DDS A;  2B3Z A;  3NXV A;  2OBC A;  1DR5 A;  1RX4 A;  1DG7 A;  1ZDR A;  2BLC A;  4Q6A A;  2JYB A;  3QYO A;  1DLS A;  2W3W A;  2W9T A;  3FQO A;  4PSS A;  2HQP A;  3K2H A;  2OIP A; 
#chains in the Genus database with same CATH topology
 4X5G A;  3F8Z A;  3QFX A;  1RX3 A;  1S3V A;  3KFY A;  1DR1 A;  5HSU A;  2QK8 A;  5HUI A;  3NXT A;  4NX6 A;  3FQF A;  3NXO A;  4XE6 X;  4DDR A;  1DF7 A;  5HT5 A;  1RB3 A;  3DRC A;  3QG2 A;  2C2S A;  1DR3 A;  1S3W A;  3K47 A;  4P66 A;  1RA3 A;  3S9U A;  1DR7 A;  4XT4 A;  3JWK A;  3LG4 A;  3S3V A;  2HXV A;  1RB2 A;  4KLX A;  4EJ1 A;  2W9G A;  4EIZ A;  3CL9 A;  3KJR A;  1JOL A;  1RG7 A;  4HOG A;  4KJJ A;  2FZI A;  4PSY A;  2D5N A;  3QLY A;  4KM0 A;  3SA1 A;  1KMS A;  1AO8 A;  3SH2 A;  2H2Q A;  3UM8 A;  3FRF X;  3L3R A;  7DFR A;  1DG8 A;  3FS6 A;  3KGY A;  1U72 A;  2O7P A;  4G3M A;  3EIG A;  3KJS A;  1RF7 A;  4H97 A;  1J3I A;  1RX5 A;  3DAT A;  4PTJ A;  5HQY A;  3JWF A;  1TDR A;  2ANQ A;  1E26 A;  1CD2 A;  3Q1H A;  5HQZ A;  3FQ0 A;  3F0Q X;  4ELF A;  1BOZ A;  3FRA X;  1RA2 A;  3NZB X;  4Q0E A;  3HJ3 A;  3NXY A;  3N0H A;  1RC4 A;  1RX7 A;  2ZZA A;  5ECX A;  5CC9 A;  3QYL A;  3QL0 A;  1RH3 A;  4ECK A;  1DR2 A;  5HSR A;  4QHV A;  1VDR A;  2XW7 A;  3FYV X;  3QLW A;  4H96 A;  1RA8 A;  3FY8 X;  1DIU A;  3IA5 A;  1LY4 A;  2KGK A;  3JW5 A;  5HPB A;  1DYR A;  3F0U X;  3FQC A;  3FRB X;  3F0V X;  1J3K A;  1QZF A;  3IRN A;  3K45 A;  8DFR A;  4G8Z X;  1DDR A;  2ANO A;  1DG5 A;  3SAI A;  3QLZ A;  1MVT A;  3RG9 A;  3E0B A;  1PD8 A;  1DRH A;  3SR5 X;  1DR4 A;  3FL9 A;  1RD7 A;  4H95 A;  1RX1 A;  3D84 X;  2W3A A;  5HT4 A;  4HOF A;  4FHB A;  1JOM A;  2CD2 A;  5HVE A;  3JWC A;  4PTH A;  5EAJ A;  4M7V A;  3NZA X;  3ZPG A;  3R33 A;  4H98 A;  2CIG A;  4KJK A;  1SEJ A;  3EX8 A;  1KLK A;  4FGG A;  4LAH X;  5U27 A;  5FDA A;  3ROA A;  1U71 A;  1DHF A;  4KBN A;  3NZ9 X;  3SRQ X;  2ITH A;  1PDB A;  1DRF A;  3GYF A;  1DHI A;  1HFQ A;  4OR7 A;  4M6J A;  3EEK A;  4HA9 A;  3TQB A;  5DXV A;  1IA1 A;  3M09 A;  3FY9 X;  3SQY X;  1KMV A;  3SRU X;  3I8A X;  3CSE A;  1LY3 A;  2BLB A;  4LAE X;  1DRE A;  4TU5 X;  2INQ A;  4XT6 A;  5JA3 A;  4KAK A;  4CD2 A;  2G6V A;  4DPH A;  4X5I A;  3JTW A;  3IA4 A;  3QL3 A;  1M7A A;  1OHK A;  1S3U A;  3GHW A;  4Q67 A;  3FL8 A;  3FYW X;  3ZPC A;  2P4G A;  5HVB A;  4HA7 A;  1DYJ A;  4ELG A;  4QJC A;  3F91 A;  3F0B X;  4X5F A;  4KFJ A;  3I3R A;  3NU0 A;  4X5H A;  1OHJ A;  3VCO A;  4KD7 A;  4M6L A;  4P68 A;  1PD9 A;  3GI2 A;  5E8Q A;  1DYI A;  4QI9 A;  4KY8 A;  2FZJ A;  3UM6 A;  3EEJ A;  5ECC A;  1DRA A;  4Q0D A;  1YHO A;  4DPD A;  1DRB A;  3RO9 A;  1DIS A;  2BLA A;  3F8Y A;  1IA3 A;  3NZC X;  4I13 A;  4XT7 A;  2DHF A;  4DP3 A;  3NZD A;  4KEB A;  3QLS A;  1DHJ A;  3INV A;  3JWM A;  1BZF A;  4PDJ A;  4QJZ D;  5HF0 X;  3TQA A;  3EEM A;  4ELE A;  1MVS A;  2D0K A;  3M08 A;  1CZ3 A;  3EEL A;  3CD2 A;  5HI6 A;  4EIL A;  1RX2 A;  4M7U A;  3OAF A;  3K74 A;  3DL6 A;  2HM9 A;  4KY4 A;  3NTZ A;  3KY8 A;  4KYA A;  3IX9 A;  1RA1 A;  1DAJ A;  5HF2 X;  2W9H A;  3IRO A;  3QLR A;  3FRE X;  4G95 A;  3DG8 A;  3FQZ A;  2W9S A;  2AZN A;  4QLE A;  1RX6 A;  4QLG A;  4P3R A;  3IRM A;  4M2X A;  1VJ3 A;  1DLR A;  1M79 A;  4OSG A;  1HFP A;  3TD8 A;  5DFR A;  4ELB A;  4DFR A;  4IXG X;  2DRC A;  3SRW X;  1LUD A;  1DYH A;  3DFR A;  5U26 A;  3F0S X;  2W3B A;  4EIG A;  1AOE A;  3NRR A;  3OCH A;  3FRD X;  3NZ6 X;  3NXX A;  4KL9 A;  3GHV A;  2LF1 A;  3TQ8 A;  1AI9 A;  3SRR X;  1IA2 A;  4XT5 A;  3DL5 A;  4I1N A;  3JW3 A;  4GH8 A;  4LAG X;  2L28 A;  2BL9 A;  3DAU A;  3JVX A;  3D80 A;  1RA9 A;  4ELH A;  1RX9 A;  3UM5 A;  1HFR A;  1J3J A;  1RX8 A;  3SA2 A;  1RE7 A;  3NXR A;  1S3Y A;  1U70 A;  2FZH A;  4KJL A;  5JG0 X;  3F0X X;  1IA4 A;  4XT8 A;  4P3Q A;  3DGA A;  4KM2 A;  2W3V A;  4QLF A;  4LEK X;  4HOE A;  3JSU A;  4X5J A;  4IXE D;  6DFR A;  4FGH A;  2W3M A;  3QGT A;  2GD9 A;  4M6K A;  4NX7 A;  4XRB A;  4KNE A;  3CLB A;  3SGY A;  1DR6 A;  1D1G A;  4IXF X;  4RGC A;  2C2T A;  4XEC X;  3SRS X;  3GHC A;  3S7A A;  1JUV A;  5CCC A;  3QLX A;  3FQV A;  1M78 A;  4PST A;  3HBB A;  3TQ9 A;  1DDS A;  2B3Z A;  3NXV A;  2OBC A;  1DR5 A;  1RX4 A;  1DG7 A;  1ZDR A;  2BLC A;  4Q6A A;  2JYB A;  3QYO A;  1DLS A;  2W3W A;  2W9T A;  3FQO A;  4PSS A;  2HQP A;  3K2H A;  2OIP A; 
#chains in the Genus database with same CATH homology
 4X5G A;  3F8Z A;  3QFX A;  1RX3 A;  1S3V A;  3KFY A;  1DR1 A;  5HSU A;  2QK8 A;  5HUI A;  3NXT A;  4NX6 A;  3FQF A;  3NXO A;  4XE6 X;  4DDR A;  1DF7 A;  5HT5 A;  1RB3 A;  3DRC A;  3QG2 A;  2C2S A;  1DR3 A;  1S3W A;  3K47 A;  4P66 A;  1RA3 A;  3S9U A;  1DR7 A;  4XT4 A;  3JWK A;  3LG4 A;  3S3V A;  2HXV A;  1RB2 A;  4KLX A;  4EJ1 A;  2W9G A;  4EIZ A;  3CL9 A;  3KJR A;  1JOL A;  1RG7 A;  4HOG A;  4KJJ A;  2FZI A;  4PSY A;  2D5N A;  3QLY A;  4KM0 A;  3SA1 A;  1KMS A;  1AO8 A;  3SH2 A;  2H2Q A;  3UM8 A;  3FRF X;  3L3R A;  7DFR A;  1DG8 A;  3FS6 A;  3KGY A;  1U72 A;  2O7P A;  4G3M A;  3EIG A;  3KJS A;  1RF7 A;  4H97 A;  1J3I A;  1RX5 A;  3DAT A;  4PTJ A;  5HQY A;  3JWF A;  1TDR A;  2ANQ A;  1E26 A;  1CD2 A;  3Q1H A;  5HQZ A;  3FQ0 A;  3F0Q X;  4ELF A;  1BOZ A;  3FRA X;  1RA2 A;  3NZB X;  4Q0E A;  3HJ3 A;  3NXY A;  3N0H A;  1RC4 A;  1RX7 A;  2ZZA A;  5ECX A;  5CC9 A;  3QYL A;  3QL0 A;  1RH3 A;  4ECK A;  1DR2 A;  5HSR A;  4QHV A;  1VDR A;  2XW7 A;  3FYV X;  3QLW A;  4H96 A;  1RA8 A;  3FY8 X;  1DIU A;  3IA5 A;  1LY4 A;  2KGK A;  3JW5 A;  5HPB A;  1DYR A;  3F0U X;  3FQC A;  3FRB X;  3F0V X;  1J3K A;  1QZF A;  3IRN A;  3K45 A;  8DFR A;  4G8Z X;  1DDR A;  2ANO A;  1DG5 A;  3SAI A;  3QLZ A;  1MVT A;  3RG9 A;  3E0B A;  1PD8 A;  1DRH A;  3SR5 X;  1DR4 A;  3FL9 A;  1RD7 A;  4H95 A;  1RX1 A;  3D84 X;  2W3A A;  5HT4 A;  4HOF A;  4FHB A;  1JOM A;  2CD2 A;  5HVE A;  3JWC A;  4PTH A;  5EAJ A;  4M7V A;  3NZA X;  3ZPG A;  3R33 A;  4H98 A;  2CIG A;  4KJK A;  1SEJ A;  3EX8 A;  1KLK A;  4FGG A;  4LAH X;  5U27 A;  5FDA A;  3ROA A;  1U71 A;  1DHF A;  4KBN A;  3NZ9 X;  3SRQ X;  2ITH A;  1PDB A;  1DRF A;  3GYF A;  1DHI A;  1HFQ A;  4OR7 A;  4M6J A;  3EEK A;  4HA9 A;  3TQB A;  5DXV A;  1IA1 A;  3M09 A;  3FY9 X;  3SQY X;  1KMV A;  3SRU X;  3I8A X;  3CSE A;  1LY3 A;  2BLB A;  4LAE X;  1DRE A;  4TU5 X;  2INQ A;  4XT6 A;  5JA3 A;  4KAK A;  4CD2 A;  2G6V A;  4DPH A;  4X5I A;  3JTW A;  3IA4 A;  3QL3 A;  1M7A A;  1OHK A;  1S3U A;  3GHW A;  4Q67 A;  3FL8 A;  3FYW X;  3ZPC A;  2P4G A;  5HVB A;  4HA7 A;  1DYJ A;  4ELG A;  4QJC A;  3F91 A;  3F0B X;  4X5F A;  4KFJ A;  3I3R A;  3NU0 A;  4X5H A;  1OHJ A;  3VCO A;  4KD7 A;  4M6L A;  4P68 A;  1PD9 A;  3GI2 A;  5E8Q A;  1DYI A;  4QI9 A;  4KY8 A;  2FZJ A;  3UM6 A;  3EEJ A;  5ECC A;  1DRA A;  4Q0D A;  1YHO A;  4DPD A;  1DRB A;  3RO9 A;  1DIS A;  2BLA A;  3F8Y A;  1IA3 A;  3NZC X;  4I13 A;  4XT7 A;  2DHF A;  4DP3 A;  3NZD A;  4KEB A;  3QLS A;  1DHJ A;  3INV A;  3JWM A;  1BZF A;  4PDJ A;  4QJZ D;  5HF0 X;  3TQA A;  3EEM A;  4ELE A;  1MVS A;  2D0K A;  3M08 A;  1CZ3 A;  3EEL A;  3CD2 A;  5HI6 A;  4EIL A;  1RX2 A;  4M7U A;  3OAF A;  3K74 A;  3DL6 A;  2HM9 A;  4KY4 A;  3NTZ A;  3KY8 A;  4KYA A;  3IX9 A;  1RA1 A;  1DAJ A;  5HF2 X;  2W9H A;  3IRO A;  3QLR A;  3FRE X;  4G95 A;  3DG8 A;  3FQZ A;  2W9S A;  2AZN A;  4QLE A;  1RX6 A;  4QLG A;  4P3R A;  3IRM A;  4M2X A;  1VJ3 A;  1DLR A;  1M79 A;  4OSG A;  1HFP A;  3TD8 A;  5DFR A;  4ELB A;  4DFR A;  4IXG X;  2DRC A;  3SRW X;  1LUD A;  1DYH A;  3DFR A;  5U26 A;  3F0S X;  2W3B A;  4EIG A;  1AOE A;  3NRR A;  3OCH A;  3FRD X;  3NZ6 X;  3NXX A;  4KL9 A;  3GHV A;  2LF1 A;  3TQ8 A;  1AI9 A;  3SRR X;  1IA2 A;  4XT5 A;  3DL5 A;  4I1N A;  3JW3 A;  4GH8 A;  4LAG X;  2L28 A;  2BL9 A;  3DAU A;  3JVX A;  3D80 A;  1RA9 A;  4ELH A;  1RX9 A;  3UM5 A;  1HFR A;  1J3J A;  1RX8 A;  3SA2 A;  1RE7 A;  3NXR A;  1S3Y A;  1U70 A;  2FZH A;  4KJL A;  5JG0 X;  3F0X X;  1IA4 A;  4XT8 A;  4P3Q A;  3DGA A;  4KM2 A;  2W3V A;  4QLF A;  4LEK X;  4HOE A;  3JSU A;  4X5J A;  4IXE D;  6DFR A;  4FGH A;  2W3M A;  3QGT A;  2GD9 A;  4M6K A;  4NX7 A;  4XRB A;  4KNE A;  3CLB A;  3SGY A;  1DR6 A;  1D1G A;  4IXF X;  4RGC A;  2C2T A;  4XEC X;  3SRS X;  3GHC A;  3S7A A;  1JUV A;  5CCC A;  3QLX A;  3FQV A;  1M78 A;  4PST A;  3HBB A;  3TQ9 A;  1DDS A;  2B3Z A;  3NXV A;  2OBC A;  1DR5 A;  1RX4 A;  1DG7 A;  1ZDR A;  2BLC A;  4Q6A A;  2JYB A;  3QYO A;  1DLS A;  2W3W A;  2W9T A;  3FQO A;  4PSS A;  2HQP A;  3K2H A;  2OIP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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