1KMSA

Human dihydrofolate reductase complexed with nadph and 6-([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (sri-9439), a lipophilic antifolate
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
184
structure length
184
Chain Sequence
SLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 55
structure length 184
sequence length 184
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2001-12-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1kmsA00
5E8QA 4QI9A 3CD2A 1IA4A 1RA9A 1RX4A 1LY3A 3VCOA 3Q1HA 1DRHA 3KJSA 4H98A 3FYVX 1S3YA 3OAFA 2ANOA 3DAUA 3FYWX 4G95A 2W9GA 2ZZAA 1M7AA 1TDRA 3FRDX 1OHKA 4ELBA 4XT5A 3JWFA 3NU0A 1ZDRA 1AI9A 3SRRX 3FREX 4I1NA 3JW5A 4PSYA 1CZ3A 1RX3A 3SA1A 2W9SA 1U72A 4X5IA 3NXTA 1DR7A 3EEJA 3NXOA 4Q0DA 4PSTA 5DXVA 4PSSA 4ELHA 2W9TA 3GHCA 1RX1A 3FY9X 4IXFX 1RC4A 2H2QA 3DL5A 3ZPGA 1DREA 4KJKA 3NXXA 2C2SA 1M79A 2W3AA 1DLSA 5HT5A 5HSUA 4P3RA 3EIGA 3DRCA 4H97A 4LAGX 4ELFA 2INQA 3FL8A 3NZCX 4X5GA 3I3RA 3FRBX 4KAKA 2KGKA 3F0UX 1IA3A 1KMSA 4P68A 3FL9A 3NXYA 4HOGA 5HF2X 4KNEA 3HJ3A 1RX2A 2HQPA 3NTZA 2ANQA 3K74A 4PTHA 1HFPA 4QLGA 3R33A 1DYJA 3SRUX 1RG7A 2QK8A 3FQOA 3FQCA 3S3VA 3F0BX 4NX7A 2FZHA 5HF0X 4NX6A 5CC9A 1RB3A 3KY8A 1DRAA 4ECKA 4DPHA 3FY8X 2W3MA 4OR7A 3UM5A 3IA5A 2DHFA 4KJLA 4Q0EA 4ELGA 3QLSA 3F8YA 1RB2A 5CCCA 5HT4A 1BOZA 3NZDA 3IROA 3SAIA 4KL9A 3QLYA 3SQYX 1OHJA 5U26A 3EEKA 4ELEA 4X5JA 4KLXA 3QLWA 4H96A 1QZFA 1DIUA 2FZIA 1RD7A 3M09A 1DHJA 3OCHA 1DDRA 4QLFA 1IA1A 1DISA 3QLZA 3NZBX 5FDAA 3TQ9A 4KY8A 1DYRA 3S9UA 4EJ1A 4QJCA 6DFRA 3DL6A 3FS6A 3SRSX 5HSRA 3UM8A 3NXRA 2BLBA 3IX9A 3TD8A 5HQYA 4GH8A 4EIZA 4P66A 1AOEA 3DG8A 3DATA 2G6VA 1VJ3A 4RGCA 4OSGA 1HFRA 4KEBA 5EAJA 2W9HA 4QJZD 1SEJA 2BL9A 3E0BA 3DGAA 1JOMA 1DLRA 3GHVA 3JSUA 4DPDA 3D80A 4KYAA 1DHFA 1DR5A 4KJJA 3QFXA 3TQBA 1S3VA 1RE7A 4DP3A 3JW3A 1DR1A 3IRNA 4XT8A 1DG5A 1PD9A 2JYBA 4KM0A 4M7UA 3JVXA 5HI6A 4DFRA 3KFYA 1DRFA 5HQZA 3S7AA 3GI2A 2OIPA 1J3IA 3EEMA 2OBCA 2D5NA 2XW7A 3QYOA 3EX8A 3IA4A 2D0KA 1J3KA 3SRQX 1RX8A 4X5FA 1CD2A 3F0VX 3EELA 4FGGA 1JUVA 3FRAX 4KY4A 3F8ZA 3JWMA 1D1GA 5U27A 1VDRA 3F91A 3GHWA 2ITHA 3QL0A 1PD8A 4XECX 4EIGA 3ROAA 3NRRA 2HM9A 3F0SX 4PDJA 3D84X 4HA7A 5ECXA 3SRWX 4IXGX 3KGYA 1DDSA 4XRBA 4Q67A 1RH3A 5HUIA 4XT7A 4XT6A 1DAJA 1DYIA 3QG2A 1RA1A 3F0XX 1MVSA 2CIGA 4LAHX 3NZ9X 4Q6AA 1U71A 3UM6A 1RA2A 1RA8A 4QLEA 2W3WA 1HFQA 1RF7A 4KFJA 3F0QX 3TQAA 5HVBA 1DR3A 2L28A 1RX9A 1U70A 4X5HA 1DR4A 4XE6X 3GYFA 3SH2A 4M6LA 1RA3A 1BZFA 3HBBA 8DFRA 1YHOA 2W3VA 1M78A 2DRCA 1DRBA 1RX6A 4QHVA 2BLAA 2P4GA 3QLRA 3NXVA 4EILA 1J3JA 1RX5A 1DHIA 2HXVA 1RX7A 1AO8A 4P3QA 4M7VA 4M6JA 2B3ZA 3LG4A 4HA9A 3CSEA 3CL9A 3QL3A 4KD7A 4PTJA 3M08A 1LUDA 3FQ0A 3JTWA 1DR6A 5JA3A 2CD2A 4G3MA 3FRFX 3K45A 3QLXA 4KM2A 1KMVA 1JOLA 2LF1A 3DFRA 4G8ZX 4M2XA 3RG9A 4CD2A 4M6KA 4I13A 3I8AX 3INVA 3TQ8A 3JWKA 3NZAX 1DR2A 3ZPCA 4HOEA 1DYHA 2O7PA 1E26A 1LY4A 3FQFA 4KBNA 3SGYA 2W3BA 1S3UA 3NZ6X 3L3RA 2FZJA 5DFRA 3FQVA 5JG0X 3N0HA 3FQZA 4LEKX 3CLBA 2AZNA 4FGHA 1MVTA 3K2HA 3SR5X 4LAEX 1IA2A 2GD9A 4IXED 7DFRA 1DG8A 2BLCA 4DDRA 1DG7A 3QYLA 4H95A 3KJRA 5ECCA 4HOFA 1PDBA 3K47A 3RO9A 1DF7A 2C2TA 3IRMA 1KLKA 4FHBA 4XT4A 1S3WA 3SA2A 5HVEA 4TU5X 3JWCA 5HPBA 3QGTA
chains in the Genus database with same CATH superfamily
5E8QA 4QI9A 3CD2A 1IA4A 1RA9A 1RX4A 1LY3A 3VCOA 3Q1HA 1DRHA 3KJSA 4H98A 3FYVX 1S3YA 3OAFA 2ANOA 3DAUA 3FYWX 4G95A 2W9GA 2ZZAA 1M7AA 1TDRA 3FRDX 1OHKA 4ELBA 4XT5A 3JWFA 3NU0A 1ZDRA 1AI9A 3SRRX 3FREX 4I1NA 3JW5A 4PSYA 1CZ3A 1RX3A 3SA1A 2W9SA 1U72A 4X5IA 3NXTA 1DR7A 3EEJA 3NXOA 4Q0DA 4PSTA 5DXVA 4PSSA 4ELHA 2W9TA 3GHCA 1RX1A 3FY9X 4IXFX 1RC4A 2H2QA 3DL5A 3ZPGA 1DREA 4KJKA 3NXXA 2C2SA 1M79A 2W3AA 1DLSA 5HT5A 5HSUA 4P3RA 3EIGA 3DRCA 4H97A 4LAGX 4ELFA 2INQA 3FL8A 3NZCX 4X5GA 3I3RA 3FRBX 4KAKA 2KGKA 3F0UX 1IA3A 1KMSA 4P68A 3FL9A 3NXYA 4HOGA 5HF2X 4KNEA 3HJ3A 1RX2A 2HQPA 3NTZA 2ANQA 3K74A 4PTHA 1HFPA 4QLGA 3R33A 1DYJA 3SRUX 1RG7A 2QK8A 3FQOA 3FQCA 3S3VA 3F0BX 4NX7A 2FZHA 5HF0X 4NX6A 5CC9A 1RB3A 3KY8A 1DRAA 4ECKA 4DPHA 3FY8X 2W3MA 4OR7A 3UM5A 3IA5A 2DHFA 4KJLA 4Q0EA 4ELGA 3QLSA 3F8YA 1RB2A 5CCCA 5HT4A 1BOZA 3NZDA 3IROA 3SAIA 4KL9A 3QLYA 3SQYX 1OHJA 5U26A 3EEKA 4ELEA 4X5JA 4KLXA 3QLWA 4H96A 1QZFA 1DIUA 2FZIA 1RD7A 3M09A 1DHJA 3OCHA 1DDRA 4QLFA 1IA1A 1DISA 3QLZA 3NZBX 5FDAA 3TQ9A 4KY8A 1DYRA 3S9UA 4EJ1A 4QJCA 6DFRA 3DL6A 3FS6A 3SRSX 5HSRA 3UM8A 3NXRA 2BLBA 3IX9A 3TD8A 5HQYA 4GH8A 4EIZA 4P66A 1AOEA 3DG8A 3DATA 2G6VA 1VJ3A 4RGCA 4OSGA 1HFRA 4KEBA 5EAJA 2W9HA 4QJZD 1SEJA 2BL9A 3E0BA 3DGAA 1JOMA 1DLRA 3GHVA 3JSUA 4DPDA 3D80A 4KYAA 1DHFA 1DR5A 4KJJA 3QFXA 3TQBA 1S3VA 1RE7A 4DP3A 3JW3A 1DR1A 3IRNA 4XT8A 1DG5A 1PD9A 2JYBA 4KM0A 4M7UA 3JVXA 5HI6A 4DFRA 3KFYA 1DRFA 5HQZA 3S7AA 3GI2A 2OIPA 1J3IA 3EEMA 2OBCA 2D5NA 2XW7A 3QYOA 3EX8A 3IA4A 2D0KA 1J3KA 3SRQX 1RX8A 4X5FA 1CD2A 3F0VX 3EELA 4FGGA 1JUVA 3FRAX 4KY4A 3F8ZA 3JWMA 1D1GA 5U27A 1VDRA 3F91A 3GHWA 2ITHA 3QL0A 1PD8A 4XECX 4EIGA 3ROAA 3NRRA 2HM9A 3F0SX 4PDJA 3D84X 4HA7A 5ECXA 3SRWX 4IXGX 3KGYA 1DDSA 4XRBA 4Q67A 1RH3A 5HUIA 4XT7A 4XT6A 1DAJA 1DYIA 3QG2A 1RA1A 3F0XX 1MVSA 2CIGA 4LAHX 3NZ9X 4Q6AA 1U71A 3UM6A 1RA2A 1RA8A 4QLEA 2W3WA 1HFQA 1RF7A 4KFJA 3F0QX 3TQAA 5HVBA 1DR3A 2L28A 1RX9A 1U70A 4X5HA 1DR4A 4XE6X 3GYFA 3SH2A 4M6LA 1RA3A 1BZFA 3HBBA 8DFRA 1YHOA 2W3VA 1M78A 2DRCA 1DRBA 1RX6A 4QHVA 2BLAA 2P4GA 3QLRA 3NXVA 4EILA 1J3JA 1RX5A 1DHIA 2HXVA 1RX7A 1AO8A 4P3QA 4M7VA 4M6JA 2B3ZA 3LG4A 4HA9A 3CSEA 3CL9A 3QL3A 4KD7A 4PTJA 3M08A 1LUDA 3FQ0A 3JTWA 1DR6A 5JA3A 2CD2A 4G3MA 3FRFX 3K45A 3QLXA 4KM2A 1KMVA 1JOLA 2LF1A 3DFRA 4G8ZX 4M2XA 3RG9A 4CD2A 4M6KA 4I13A 3I8AX 3INVA 3TQ8A 3JWKA 3NZAX 1DR2A 3ZPCA 4HOEA 1DYHA 2O7PA 1E26A 1LY4A 3FQFA 4KBNA 3SGYA 2W3BA 1S3UA 3NZ6X 3L3RA 2FZJA 5DFRA 3FQVA 5JG0X 3N0HA 3FQZA 4LEKX 3CLBA 2AZNA 4FGHA 1MVTA 3K2HA 3SR5X 4LAEX 1IA2A 2GD9A 4IXED 7DFRA 1DG8A 2BLCA 4DDRA 1DG7A 3QYLA 4H95A 3KJRA 5ECCA 4HOFA 1PDBA 3K47A 3RO9A 1DF7A 2C2TA 3IRMA 1KLKA 4FHBA 4XT4A 1S3WA 3SA2A 5HVEA 4TU5X 3JWCA 5HPBA 3QGTA
chains in the Genus database with same CATH topology
5E8QA 4QI9A 3CD2A 1IA4A 1RA9A 1RX4A 1LY3A 3VCOA 3Q1HA 1DRHA 3KJSA 4H98A 3FYVX 1S3YA 3OAFA 2ANOA 3DAUA 3FYWX 4G95A 2W9GA 2ZZAA 1M7AA 1TDRA 3FRDX 1OHKA 4ELBA 4XT5A 3JWFA 3NU0A 1ZDRA 1AI9A 3SRRX 3FREX 4I1NA 3JW5A 4PSYA 1CZ3A 1RX3A 3SA1A 2W9SA 1U72A 4X5IA 3NXTA 1DR7A 3EEJA 3NXOA 4Q0DA 4PSTA 5DXVA 4PSSA 4ELHA 2W9TA 3GHCA 1RX1A 3FY9X 4IXFX 1RC4A 2H2QA 3DL5A 3ZPGA 1DREA 4KJKA 3NXXA 2C2SA 1M79A 2W3AA 1DLSA 5HT5A 5HSUA 4P3RA 3EIGA 3DRCA 4H97A 4LAGX 4ELFA 2INQA 3FL8A 3NZCX 4X5GA 3I3RA 3FRBX 4KAKA 2KGKA 3F0UX 1IA3A 1KMSA 4P68A 3FL9A 3NXYA 4HOGA 5HF2X 4KNEA 3HJ3A 1RX2A 2HQPA 3NTZA 2ANQA 3K74A 4PTHA 1HFPA 4QLGA 3R33A 1DYJA 3SRUX 1RG7A 2QK8A 3FQOA 3FQCA 3S3VA 3F0BX 4NX7A 2FZHA 5HF0X 4NX6A 5CC9A 1RB3A 3KY8A 1DRAA 4ECKA 4DPHA 3FY8X 2W3MA 4OR7A 3UM5A 3IA5A 2DHFA 4KJLA 4Q0EA 4ELGA 3QLSA 3F8YA 1RB2A 5CCCA 5HT4A 1BOZA 3NZDA 3IROA 3SAIA 4KL9A 3QLYA 3SQYX 1OHJA 5U26A 3EEKA 4ELEA 4X5JA 4KLXA 3QLWA 4H96A 1QZFA 1DIUA 2FZIA 1RD7A 3M09A 1DHJA 3OCHA 1DDRA 4QLFA 1IA1A 1DISA 3QLZA 3NZBX 5FDAA 3TQ9A 4KY8A 1DYRA 3S9UA 4EJ1A 4QJCA 6DFRA 3DL6A 3FS6A 3SRSX 5HSRA 3UM8A 3NXRA 2BLBA 3IX9A 3TD8A 5HQYA 4GH8A 4EIZA 4P66A 1AOEA 3DG8A 3DATA 2G6VA 1VJ3A 4RGCA 4OSGA 1HFRA 4KEBA 5EAJA 2W9HA 4QJZD 1SEJA 2BL9A 3E0BA 3DGAA 1JOMA 1DLRA 3GHVA 3JSUA 4DPDA 3D80A 4KYAA 1DHFA 1DR5A 4KJJA 3QFXA 3TQBA 1S3VA 1RE7A 4DP3A 3JW3A 1DR1A 3IRNA 4XT8A 1DG5A 1PD9A 2JYBA 4KM0A 4M7UA 3JVXA 5HI6A 4DFRA 3KFYA 1DRFA 5HQZA 3S7AA 3GI2A 2OIPA 1J3IA 3EEMA 2OBCA 2D5NA 2XW7A 3QYOA 3EX8A 3IA4A 2D0KA 1J3KA 3SRQX 1RX8A 4X5FA 1CD2A 3F0VX 3EELA 4FGGA 1JUVA 3FRAX 4KY4A 3F8ZA 3JWMA 1D1GA 5U27A 1VDRA 3F91A 3GHWA 2ITHA 3QL0A 1PD8A 4XECX 4EIGA 3ROAA 3NRRA 2HM9A 3F0SX 4PDJA 3D84X 4HA7A 5ECXA 3SRWX 4IXGX 3KGYA 1DDSA 4XRBA 4Q67A 1RH3A 5HUIA 4XT7A 4XT6A 1DAJA 1DYIA 3QG2A 1RA1A 3F0XX 1MVSA 2CIGA 4LAHX 3NZ9X 4Q6AA 1U71A 3UM6A 1RA2A 1RA8A 4QLEA 2W3WA 1HFQA 1RF7A 4KFJA 3F0QX 3TQAA 5HVBA 1DR3A 2L28A 1RX9A 1U70A 4X5HA 1DR4A 4XE6X 3GYFA 3SH2A 4M6LA 1RA3A 1BZFA 3HBBA 8DFRA 1YHOA 2W3VA 1M78A 2DRCA 1DRBA 1RX6A 4QHVA 2BLAA 2P4GA 3QLRA 3NXVA 4EILA 1J3JA 1RX5A 1DHIA 2HXVA 1RX7A 1AO8A 4P3QA 4M7VA 4M6JA 2B3ZA 3LG4A 4HA9A 3CSEA 3CL9A 3QL3A 4KD7A 4PTJA 3M08A 1LUDA 3FQ0A 3JTWA 1DR6A 5JA3A 2CD2A 4G3MA 3FRFX 3K45A 3QLXA 4KM2A 1KMVA 1JOLA 2LF1A 3DFRA 4G8ZX 4M2XA 3RG9A 4CD2A 4M6KA 4I13A 3I8AX 3INVA 3TQ8A 3JWKA 3NZAX 1DR2A 3ZPCA 4HOEA 1DYHA 2O7PA 1E26A 1LY4A 3FQFA 4KBNA 3SGYA 2W3BA 1S3UA 3NZ6X 3L3RA 2FZJA 5DFRA 3FQVA 5JG0X 3N0HA 3FQZA 4LEKX 3CLBA 2AZNA 4FGHA 1MVTA 3K2HA 3SR5X 4LAEX 1IA2A 2GD9A 4IXED 7DFRA 1DG8A 2BLCA 4DDRA 1DG7A 3QYLA 4H95A 3KJRA 5ECCA 4HOFA 1PDBA 3K47A 3RO9A 1DF7A 2C2TA 3IRMA 1KLKA 4FHBA 4XT4A 1S3WA 3SA2A 5HVEA 4TU5X 3JWCA 5HPBA 3QGTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5E8Q A;  4QI9 A;  3CD2 A;  1IA4 A;  1RA9 A;  1RX4 A;  1LY3 A;  3VCO A;  3Q1H A;  1DRH A;  3KJS A;  4H98 A;  3FYV X;  1S3Y A;  3OAF A;  2ANO A;  3DAU A;  3FYW X;  4G95 A;  2W9G A;  2ZZA A;  1M7A A;  1TDR A;  3FRD X;  1OHK A;  4ELB A;  4XT5 A;  3JWF A;  3NU0 A;  1ZDR A;  1AI9 A;  3SRR X;  3FRE X;  4I1N A;  3JW5 A;  4PSY A;  1CZ3 A;  1RX3 A;  3SA1 A;  2W9S A;  1U72 A;  4X5I A;  3NXT A;  1DR7 A;  3EEJ A;  3NXO A;  4Q0D A;  4PST A;  5DXV A;  4PSS A;  4ELH A;  2W9T A;  3GHC A;  1RX1 A;  3FY9 X;  4IXF X;  1RC4 A;  2H2Q A;  3DL5 A;  3ZPG A;  1DRE A;  4KJK A;  3NXX A;  2C2S A;  1M79 A;  2W3A A;  1DLS A;  5HT5 A;  5HSU A;  4P3R A;  3EIG A;  3DRC A;  4H97 A;  4LAG X;  4ELF A;  2INQ A;  3FL8 A;  3NZC X;  4X5G A;  3I3R A;  3FRB X;  4KAK A;  2KGK A;  3F0U X;  1IA3 A;  1KMS A;  4P68 A;  3FL9 A;  3NXY A;  4HOG A;  5HF2 X;  4KNE A;  3HJ3 A;  1RX2 A;  2HQP A;  3NTZ A;  2ANQ A;  3K74 A;  4PTH A;  1HFP A;  4QLG A;  3R33 A;  1DYJ A;  3SRU X;  1RG7 A;  2QK8 A;  3FQO A;  3FQC A;  3S3V A;  3F0B X;  4NX7 A;  2FZH A;  5HF0 X;  4NX6 A;  5CC9 A;  1RB3 A;  3KY8 A;  1DRA A;  4ECK A;  4DPH A;  3FY8 X;  2W3M A;  4OR7 A;  3UM5 A;  3IA5 A;  2DHF A;  4KJL A;  4Q0E A;  4ELG A;  3QLS A;  3F8Y A;  1RB2 A;  5CCC A;  5HT4 A;  1BOZ A;  3NZD A;  3IRO A;  3SAI A;  4KL9 A;  3QLY A;  3SQY X;  1OHJ A;  5U26 A;  3EEK A;  4ELE A;  4X5J A;  4KLX A;  3QLW A;  4H96 A;  1QZF A;  1DIU A;  2FZI A;  1RD7 A;  3M09 A;  1DHJ A;  3OCH A;  1DDR A;  4QLF A;  1IA1 A;  1DIS A;  3QLZ A;  3NZB X;  5FDA A;  3TQ9 A;  4KY8 A;  1DYR A;  3S9U A;  4EJ1 A;  4QJC A;  6DFR A;  3DL6 A;  3FS6 A;  3SRS X;  5HSR A;  3UM8 A;  3NXR A;  2BLB A;  3IX9 A;  3TD8 A;  5HQY A;  4GH8 A;  4EIZ A;  4P66 A;  1AOE A;  3DG8 A;  3DAT A;  2G6V A;  1VJ3 A;  4RGC A;  4OSG A;  1HFR A;  4KEB A;  5EAJ A;  2W9H A;  4QJZ D;  1SEJ A;  2BL9 A;  3E0B A;  3DGA A;  1JOM A;  1DLR A;  3GHV A;  3JSU A;  4DPD A;  3D80 A;  4KYA A;  1DHF A;  1DR5 A;  4KJJ A;  3QFX A;  3TQB A;  1S3V A;  1RE7 A;  4DP3 A;  3JW3 A;  1DR1 A;  3IRN A;  4XT8 A;  1DG5 A;  1PD9 A;  2JYB A;  4KM0 A;  4M7U A;  3JVX A;  5HI6 A;  4DFR A;  3KFY A;  1DRF A;  5HQZ A;  3S7A A;  3GI2 A;  2OIP A;  1J3I A;  3EEM A;  2OBC A;  2D5N A;  2XW7 A;  3QYO A;  3EX8 A;  3IA4 A;  2D0K A;  1J3K A;  3SRQ X;  1RX8 A;  4X5F A;  1CD2 A;  3F0V X;  3EEL A;  4FGG A;  1JUV A;  3FRA X;  4KY4 A;  3F8Z A;  3JWM A;  1D1G A;  5U27 A;  1VDR A;  3F91 A;  3GHW A;  2ITH A;  3QL0 A;  1PD8 A;  4XEC X;  4EIG A;  3ROA A;  3NRR A;  2HM9 A;  3F0S X;  4PDJ A;  3D84 X;  4HA7 A;  5ECX A;  3SRW X;  4IXG X;  3KGY A;  1DDS A;  4XRB A;  4Q67 A;  1RH3 A;  5HUI A;  4XT7 A;  4XT6 A;  1DAJ A;  1DYI A;  3QG2 A;  1RA1 A;  3F0X X;  1MVS A;  2CIG A;  4LAH X;  3NZ9 X;  4Q6A A;  1U71 A;  3UM6 A;  1RA2 A;  1RA8 A;  4QLE A;  2W3W A;  1HFQ A;  1RF7 A;  4KFJ A;  3F0Q X;  3TQA A;  5HVB A;  1DR3 A;  2L28 A;  1RX9 A;  1U70 A;  4X5H A;  1DR4 A;  4XE6 X;  3GYF A;  3SH2 A;  4M6L A;  1RA3 A;  1BZF A;  3HBB A;  8DFR A;  1YHO A;  2W3V A;  1M78 A;  2DRC A;  1DRB A;  1RX6 A;  4QHV A;  2BLA A;  2P4G A;  3QLR A;  3NXV A;  4EIL A;  1J3J A;  1RX5 A;  1DHI A;  2HXV A;  1RX7 A;  1AO8 A;  4P3Q A;  4M7V A;  4M6J A;  2B3Z A;  3LG4 A;  4HA9 A;  3CSE A;  3CL9 A;  3QL3 A;  4KD7 A;  4PTJ A;  3M08 A;  1LUD A;  3FQ0 A;  3JTW A;  1DR6 A;  5JA3 A;  2CD2 A;  4G3M A;  3FRF X;  3K45 A;  3QLX A;  4KM2 A;  1KMV A;  1JOL A;  2LF1 A;  3DFR A;  4G8Z X;  4M2X A;  3RG9 A;  4CD2 A;  4M6K A;  4I13 A;  3I8A X;  3INV A;  3TQ8 A;  3JWK A;  3NZA X;  1DR2 A;  3ZPC A;  4HOE A;  1DYH A;  2O7P A;  1E26 A;  1LY4 A;  3FQF A;  4KBN A;  3SGY A;  2W3B A;  1S3U A;  3NZ6 X;  3L3R A;  2FZJ A;  5DFR A;  3FQV A;  5JG0 X;  3N0H A;  3FQZ A;  4LEK X;  3CLB A;  2AZN A;  4FGH A;  1MVT A;  3K2H A;  3SR5 X;  4LAE X;  1IA2 A;  2GD9 A;  4IXE D;  7DFR A;  1DG8 A;  2BLC A;  4DDR A;  1DG7 A;  3QYL A;  4H95 A;  3KJR A;  5ECC A;  4HOF A;  1PDB A;  3K47 A;  3RO9 A;  1DF7 A;  2C2T A;  3IRM A;  1KLK A;  4FHB A;  4XT4 A;  1S3W A;  3SA2 A;  5HVE A;  4TU5 X;  3JWC A;  5HPB A;  3QGT A; 
#chains in the Genus database with same CATH topology
 5E8Q A;  4QI9 A;  3CD2 A;  1IA4 A;  1RA9 A;  1RX4 A;  1LY3 A;  3VCO A;  3Q1H A;  1DRH A;  3KJS A;  4H98 A;  3FYV X;  1S3Y A;  3OAF A;  2ANO A;  3DAU A;  3FYW X;  4G95 A;  2W9G A;  2ZZA A;  1M7A A;  1TDR A;  3FRD X;  1OHK A;  4ELB A;  4XT5 A;  3JWF A;  3NU0 A;  1ZDR A;  1AI9 A;  3SRR X;  3FRE X;  4I1N A;  3JW5 A;  4PSY A;  1CZ3 A;  1RX3 A;  3SA1 A;  2W9S A;  1U72 A;  4X5I A;  3NXT A;  1DR7 A;  3EEJ A;  3NXO A;  4Q0D A;  4PST A;  5DXV A;  4PSS A;  4ELH A;  2W9T A;  3GHC A;  1RX1 A;  3FY9 X;  4IXF X;  1RC4 A;  2H2Q A;  3DL5 A;  3ZPG A;  1DRE A;  4KJK A;  3NXX A;  2C2S A;  1M79 A;  2W3A A;  1DLS A;  5HT5 A;  5HSU A;  4P3R A;  3EIG A;  3DRC A;  4H97 A;  4LAG X;  4ELF A;  2INQ A;  3FL8 A;  3NZC X;  4X5G A;  3I3R A;  3FRB X;  4KAK A;  2KGK A;  3F0U X;  1IA3 A;  1KMS A;  4P68 A;  3FL9 A;  3NXY A;  4HOG A;  5HF2 X;  4KNE A;  3HJ3 A;  1RX2 A;  2HQP A;  3NTZ A;  2ANQ A;  3K74 A;  4PTH A;  1HFP A;  4QLG A;  3R33 A;  1DYJ A;  3SRU X;  1RG7 A;  2QK8 A;  3FQO A;  3FQC A;  3S3V A;  3F0B X;  4NX7 A;  2FZH A;  5HF0 X;  4NX6 A;  5CC9 A;  1RB3 A;  3KY8 A;  1DRA A;  4ECK A;  4DPH A;  3FY8 X;  2W3M A;  4OR7 A;  3UM5 A;  3IA5 A;  2DHF A;  4KJL A;  4Q0E A;  4ELG A;  3QLS A;  3F8Y A;  1RB2 A;  5CCC A;  5HT4 A;  1BOZ A;  3NZD A;  3IRO A;  3SAI A;  4KL9 A;  3QLY A;  3SQY X;  1OHJ A;  5U26 A;  3EEK A;  4ELE A;  4X5J A;  4KLX A;  3QLW A;  4H96 A;  1QZF A;  1DIU A;  2FZI A;  1RD7 A;  3M09 A;  1DHJ A;  3OCH A;  1DDR A;  4QLF A;  1IA1 A;  1DIS A;  3QLZ A;  3NZB X;  5FDA A;  3TQ9 A;  4KY8 A;  1DYR A;  3S9U A;  4EJ1 A;  4QJC A;  6DFR A;  3DL6 A;  3FS6 A;  3SRS X;  5HSR A;  3UM8 A;  3NXR A;  2BLB A;  3IX9 A;  3TD8 A;  5HQY A;  4GH8 A;  4EIZ A;  4P66 A;  1AOE A;  3DG8 A;  3DAT A;  2G6V A;  1VJ3 A;  4RGC A;  4OSG A;  1HFR A;  4KEB A;  5EAJ A;  2W9H A;  4QJZ D;  1SEJ A;  2BL9 A;  3E0B A;  3DGA A;  1JOM A;  1DLR A;  3GHV A;  3JSU A;  4DPD A;  3D80 A;  4KYA A;  1DHF A;  1DR5 A;  4KJJ A;  3QFX A;  3TQB A;  1S3V A;  1RE7 A;  4DP3 A;  3JW3 A;  1DR1 A;  3IRN A;  4XT8 A;  1DG5 A;  1PD9 A;  2JYB A;  4KM0 A;  4M7U A;  3JVX A;  5HI6 A;  4DFR A;  3KFY A;  1DRF A;  5HQZ A;  3S7A A;  3GI2 A;  2OIP A;  1J3I A;  3EEM A;  2OBC A;  2D5N A;  2XW7 A;  3QYO A;  3EX8 A;  3IA4 A;  2D0K A;  1J3K A;  3SRQ X;  1RX8 A;  4X5F A;  1CD2 A;  3F0V X;  3EEL A;  4FGG A;  1JUV A;  3FRA X;  4KY4 A;  3F8Z A;  3JWM A;  1D1G A;  5U27 A;  1VDR A;  3F91 A;  3GHW A;  2ITH A;  3QL0 A;  1PD8 A;  4XEC X;  4EIG A;  3ROA A;  3NRR A;  2HM9 A;  3F0S X;  4PDJ A;  3D84 X;  4HA7 A;  5ECX A;  3SRW X;  4IXG X;  3KGY A;  1DDS A;  4XRB A;  4Q67 A;  1RH3 A;  5HUI A;  4XT7 A;  4XT6 A;  1DAJ A;  1DYI A;  3QG2 A;  1RA1 A;  3F0X X;  1MVS A;  2CIG A;  4LAH X;  3NZ9 X;  4Q6A A;  1U71 A;  3UM6 A;  1RA2 A;  1RA8 A;  4QLE A;  2W3W A;  1HFQ A;  1RF7 A;  4KFJ A;  3F0Q X;  3TQA A;  5HVB A;  1DR3 A;  2L28 A;  1RX9 A;  1U70 A;  4X5H A;  1DR4 A;  4XE6 X;  3GYF A;  3SH2 A;  4M6L A;  1RA3 A;  1BZF A;  3HBB A;  8DFR A;  1YHO A;  2W3V A;  1M78 A;  2DRC A;  1DRB A;  1RX6 A;  4QHV A;  2BLA A;  2P4G A;  3QLR A;  3NXV A;  4EIL A;  1J3J A;  1RX5 A;  1DHI A;  2HXV A;  1RX7 A;  1AO8 A;  4P3Q A;  4M7V A;  4M6J A;  2B3Z A;  3LG4 A;  4HA9 A;  3CSE A;  3CL9 A;  3QL3 A;  4KD7 A;  4PTJ A;  3M08 A;  1LUD A;  3FQ0 A;  3JTW A;  1DR6 A;  5JA3 A;  2CD2 A;  4G3M A;  3FRF X;  3K45 A;  3QLX A;  4KM2 A;  1KMV A;  1JOL A;  2LF1 A;  3DFR A;  4G8Z X;  4M2X A;  3RG9 A;  4CD2 A;  4M6K A;  4I13 A;  3I8A X;  3INV A;  3TQ8 A;  3JWK A;  3NZA X;  1DR2 A;  3ZPC A;  4HOE A;  1DYH A;  2O7P A;  1E26 A;  1LY4 A;  3FQF A;  4KBN A;  3SGY A;  2W3B A;  1S3U A;  3NZ6 X;  3L3R A;  2FZJ A;  5DFR A;  3FQV A;  5JG0 X;  3N0H A;  3FQZ A;  4LEK X;  3CLB A;  2AZN A;  4FGH A;  1MVT A;  3K2H A;  3SR5 X;  4LAE X;  1IA2 A;  2GD9 A;  4IXE D;  7DFR A;  1DG8 A;  2BLC A;  4DDR A;  1DG7 A;  3QYL A;  4H95 A;  3KJR A;  5ECC A;  4HOF A;  1PDB A;  3K47 A;  3RO9 A;  1DF7 A;  2C2T A;  3IRM A;  1KLK A;  4FHB A;  4XT4 A;  1S3W A;  3SA2 A;  5HVE A;  4TU5 X;  3JWC A;  5HPB A;  3QGT A; 
#chains in the Genus database with same CATH homology
 5E8Q A;  4QI9 A;  3CD2 A;  1IA4 A;  1RA9 A;  1RX4 A;  1LY3 A;  3VCO A;  3Q1H A;  1DRH A;  3KJS A;  4H98 A;  3FYV X;  1S3Y A;  3OAF A;  2ANO A;  3DAU A;  3FYW X;  4G95 A;  2W9G A;  2ZZA A;  1M7A A;  1TDR A;  3FRD X;  1OHK A;  4ELB A;  4XT5 A;  3JWF A;  3NU0 A;  1ZDR A;  1AI9 A;  3SRR X;  3FRE X;  4I1N A;  3JW5 A;  4PSY A;  1CZ3 A;  1RX3 A;  3SA1 A;  2W9S A;  1U72 A;  4X5I A;  3NXT A;  1DR7 A;  3EEJ A;  3NXO A;  4Q0D A;  4PST A;  5DXV A;  4PSS A;  4ELH A;  2W9T A;  3GHC A;  1RX1 A;  3FY9 X;  4IXF X;  1RC4 A;  2H2Q A;  3DL5 A;  3ZPG A;  1DRE A;  4KJK A;  3NXX A;  2C2S A;  1M79 A;  2W3A A;  1DLS A;  5HT5 A;  5HSU A;  4P3R A;  3EIG A;  3DRC A;  4H97 A;  4LAG X;  4ELF A;  2INQ A;  3FL8 A;  3NZC X;  4X5G A;  3I3R A;  3FRB X;  4KAK A;  2KGK A;  3F0U X;  1IA3 A;  1KMS A;  4P68 A;  3FL9 A;  3NXY A;  4HOG A;  5HF2 X;  4KNE A;  3HJ3 A;  1RX2 A;  2HQP A;  3NTZ A;  2ANQ A;  3K74 A;  4PTH A;  1HFP A;  4QLG A;  3R33 A;  1DYJ A;  3SRU X;  1RG7 A;  2QK8 A;  3FQO A;  3FQC A;  3S3V A;  3F0B X;  4NX7 A;  2FZH A;  5HF0 X;  4NX6 A;  5CC9 A;  1RB3 A;  3KY8 A;  1DRA A;  4ECK A;  4DPH A;  3FY8 X;  2W3M A;  4OR7 A;  3UM5 A;  3IA5 A;  2DHF A;  4KJL A;  4Q0E A;  4ELG A;  3QLS A;  3F8Y A;  1RB2 A;  5CCC A;  5HT4 A;  1BOZ A;  3NZD A;  3IRO A;  3SAI A;  4KL9 A;  3QLY A;  3SQY X;  1OHJ A;  5U26 A;  3EEK A;  4ELE A;  4X5J A;  4KLX A;  3QLW A;  4H96 A;  1QZF A;  1DIU A;  2FZI A;  1RD7 A;  3M09 A;  1DHJ A;  3OCH A;  1DDR A;  4QLF A;  1IA1 A;  1DIS A;  3QLZ A;  3NZB X;  5FDA A;  3TQ9 A;  4KY8 A;  1DYR A;  3S9U A;  4EJ1 A;  4QJC A;  6DFR A;  3DL6 A;  3FS6 A;  3SRS X;  5HSR A;  3UM8 A;  3NXR A;  2BLB A;  3IX9 A;  3TD8 A;  5HQY A;  4GH8 A;  4EIZ A;  4P66 A;  1AOE A;  3DG8 A;  3DAT A;  2G6V A;  1VJ3 A;  4RGC A;  4OSG A;  1HFR A;  4KEB A;  5EAJ A;  2W9H A;  4QJZ D;  1SEJ A;  2BL9 A;  3E0B A;  3DGA A;  1JOM A;  1DLR A;  3GHV A;  3JSU A;  4DPD A;  3D80 A;  4KYA A;  1DHF A;  1DR5 A;  4KJJ A;  3QFX A;  3TQB A;  1S3V A;  1RE7 A;  4DP3 A;  3JW3 A;  1DR1 A;  3IRN A;  4XT8 A;  1DG5 A;  1PD9 A;  2JYB A;  4KM0 A;  4M7U A;  3JVX A;  5HI6 A;  4DFR A;  3KFY A;  1DRF A;  5HQZ A;  3S7A A;  3GI2 A;  2OIP A;  1J3I A;  3EEM A;  2OBC A;  2D5N A;  2XW7 A;  3QYO A;  3EX8 A;  3IA4 A;  2D0K A;  1J3K A;  3SRQ X;  1RX8 A;  4X5F A;  1CD2 A;  3F0V X;  3EEL A;  4FGG A;  1JUV A;  3FRA X;  4KY4 A;  3F8Z A;  3JWM A;  1D1G A;  5U27 A;  1VDR A;  3F91 A;  3GHW A;  2ITH A;  3QL0 A;  1PD8 A;  4XEC X;  4EIG A;  3ROA A;  3NRR A;  2HM9 A;  3F0S X;  4PDJ A;  3D84 X;  4HA7 A;  5ECX A;  3SRW X;  4IXG X;  3KGY A;  1DDS A;  4XRB A;  4Q67 A;  1RH3 A;  5HUI A;  4XT7 A;  4XT6 A;  1DAJ A;  1DYI A;  3QG2 A;  1RA1 A;  3F0X X;  1MVS A;  2CIG A;  4LAH X;  3NZ9 X;  4Q6A A;  1U71 A;  3UM6 A;  1RA2 A;  1RA8 A;  4QLE A;  2W3W A;  1HFQ A;  1RF7 A;  4KFJ A;  3F0Q X;  3TQA A;  5HVB A;  1DR3 A;  2L28 A;  1RX9 A;  1U70 A;  4X5H A;  1DR4 A;  4XE6 X;  3GYF A;  3SH2 A;  4M6L A;  1RA3 A;  1BZF A;  3HBB A;  8DFR A;  1YHO A;  2W3V A;  1M78 A;  2DRC A;  1DRB A;  1RX6 A;  4QHV A;  2BLA A;  2P4G A;  3QLR A;  3NXV A;  4EIL A;  1J3J A;  1RX5 A;  1DHI A;  2HXV A;  1RX7 A;  1AO8 A;  4P3Q A;  4M7V A;  4M6J A;  2B3Z A;  3LG4 A;  4HA9 A;  3CSE A;  3CL9 A;  3QL3 A;  4KD7 A;  4PTJ A;  3M08 A;  1LUD A;  3FQ0 A;  3JTW A;  1DR6 A;  5JA3 A;  2CD2 A;  4G3M A;  3FRF X;  3K45 A;  3QLX A;  4KM2 A;  1KMV A;  1JOL A;  2LF1 A;  3DFR A;  4G8Z X;  4M2X A;  3RG9 A;  4CD2 A;  4M6K A;  4I13 A;  3I8A X;  3INV A;  3TQ8 A;  3JWK A;  3NZA X;  1DR2 A;  3ZPC A;  4HOE A;  1DYH A;  2O7P A;  1E26 A;  1LY4 A;  3FQF A;  4KBN A;  3SGY A;  2W3B A;  1S3U A;  3NZ6 X;  3L3R A;  2FZJ A;  5DFR A;  3FQV A;  5JG0 X;  3N0H A;  3FQZ A;  4LEK X;  3CLB A;  2AZN A;  4FGH A;  1MVT A;  3K2H A;  3SR5 X;  4LAE X;  1IA2 A;  2GD9 A;  4IXE D;  7DFR A;  1DG8 A;  2BLC A;  4DDR A;  1DG7 A;  3QYL A;  4H95 A;  3KJR A;  5ECC A;  4HOF A;  1PDB A;  3K47 A;  3RO9 A;  1DF7 A;  2C2T A;  3IRM A;  1KLK A;  4FHB A;  4XT4 A;  1S3W A;  3SA2 A;  5HVE A;  4TU5 X;  3JWC A;  5HPB A;  3QGT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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