1PD9A

Analysis of three crystal structure determinations of a 5-methyl-6-n-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2003-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1pd9A00
1CZ3A 2W9HA 1DR3A 1IA2A 1M79A 5ECCA 3EIGA 4M6LA 2FZJA 1ZDRA 1DF7A 3FQFA 4OSGA 4PTHA 3TQAA 2W3MA 4NX6A 3K47A 4PSYA 1D1GA 3ZPGA 1DR6A 1RX4A 3NXTA 1U70A 4XT8A 3SGYA 3CL9A 2P4GA 5ECXA 3S3VA 5CC9A 1DR2A 4M6JA 2W3BA 1RA9A 3NZCX 1DIUA 3N0HA 2GD9A 4P68A 3F0QX 3DL6A 4QJZD 3NU0A 4PDJA 1DYJA 3QG2A 4FGGA 5HSUA 2AZNA 4KL9A 1DG5A 4H98A 4KJLA 4X5HA 1DR5A 2BLAA 3QLWA 1QZFA 3K45A 3QLRA 1CD2A 1S3YA 1AOEA 4DFRA 3K74A 3FY9X 3DFRA 1RX9A 3S7AA 3TD8A 1DDRA 3IA5A 3FQ0A 4G95A 2B3ZA 2C2TA 3NTZA 3LG4A 1HFRA 1DRFA 1KMSA 1DRAA 3NXRA 2W3AA 3FRBX 3S9UA 2XW7A 4QLFA 2ITHA 1LUDA 3F0UX 1RX2A 7DFRA 3FL9A 1DYHA 3NXVA 1OHJA 3SA1A 3NXOA 5U27A 1PDBA 4KM2A 1RX8A 4PSTA 2DHFA 1DYRA 4P66A 3FYVX 4XT4A 3VCOA 3JWKA 5HT5A 2H2QA 3NRRA 1E26A 1DR4A 2BL9A 3R33A 3DG8A 3FREX 4KM0A 4KJJA 1DAJA 4PTJA 4XT7A 3SR5X 2C2SA 4DPHA 4X5GA 4LEKX 3SRUX 4FGHA 4XT5A 5HQYA 3FRFX 4HOGA 4QHVA 3IROA 4X5FA 3OAFA 1RC4A 3SRSX 3RO9A 3FQOA 3QYOA 1M7AA 3JWFA 1RX1A 1VJ3A 5DFRA 3D84X 1RG7A 1MVSA 1LY3A 2DRCA 4KNEA 3OCHA 2D0KA 3HBBA 3I8AX 4G8ZX 3K2HA 3NXYA 1RX6A 3QL0A 4KY4A 1DHIA 2CIGA 3FRAX 4CD2A 2HQPA 1DRHA 3JVXA 4OR7A 3NZ9X 3TQBA 1JUVA 1RA1A 3SRWX 4KAKA 4Q67A 3INVA 3SQYX 2FZIA 3F0VX 3QLSA 5U26A 1S3VA 4M7VA 3DATA 4HA7A 1BOZA 4X5JA 3JWCA 1U71A 3CD2A 3IRMA 3NZDA 4KD7A 1DHJA 1RB3A 4I1NA 4KFJA 4TU5X 4QI9A 1IA4A 3TQ9A 1J3IA 2HM9A 5HF2X 3NZBX 5HQZA 4Q0DA 2G6VA 3DL5A 1RX3A 1PD8A 3EX8A 1RE7A 4HOFA 3FY8X 4LAEX 3ZPCA 2W3WA 1J3JA 5EAJA 1RX5A 2HXVA 3F8YA 4NX7A 2W9SA 3KGYA 3FRDX 3NXXA 4IXFX 1HFPA 3L3RA 3UM5A 4P3RA 4HA9A 2OIPA 4Q0EA 3QLXA 1IA1A 1RB2A 4KJKA 5JG0X 4M7UA 1DRBA 4X5IA 3GHWA 3QLYA 8DFRA 3FQCA 1IA3A 1KLKA 1RA3A 4XECX 3KJRA 1RA8A 4H95A 2FZHA 4ELGA 4DDRA 1TDRA 1DDSA 4QJCA 3E0BA 2L28A 4KEBA 4Q6AA 2OBCA 3JW5A 1DG8A 3D80A 4KLXA 2LF1A 1AI9A 3NZ6X 3NZAX 3JSUA 3SRRX 1S3WA 3DAUA 3JW3A 3FL8A 5HI6A 1DISA 1RA2A 4H96A 1RH3A 3GHVA 4ECKA 4ELBA 3IRNA 3ROAA 5HVEA 1KMVA 3QGTA 1DR7A 2INQA 2W3VA 4HOEA 3RG9A 4PSSA 2JYBA 3F91A 1OHKA 5HSRA 4G3MA 4FHBA 3JTWA 3EEJA 5HT4A 3FQZA 2ANOA 4KY8A 5HVBA 1U72A 4EIZA 1M78A 3GI2A 3HJ3A 4ELEA 1RD7A 3CSEA 5HPBA 2O7PA 5HUIA 4LAGX 3CLBA 4RGCA 2QK8A 4H97A 3EELA 1RF7A 1YHOA 5HF0X 3SA2A 1MVTA 4P3QA 3QYLA 3IX9A 2KGKA 4DP3A 5DXVA 3QFXA 5FDAA 1DHFA 1DG7A 3SAIA 4M2XA 1JOLA 4ELFA 3IA4A 3QL3A 3FQVA 3M08A 6DFRA 2ZZAA 5CCCA 1DYIA 2BLCA 3UM8A 3I3RA 1AO8A 4IXGX 3KY8A 3DGAA 3SH2A 3GHCA 4GH8A 1JOMA 2CD2A 4QLEA 1VDRA 1LY4A 1HFQA 3GYFA 4QLGA 3F0XX 3EEMA 2ANQA 4XRBA 4EJ1A 3KJSA 4XE6X 2D5NA 1DR1A 2W9TA 4I13A 4KYAA 5E8QA 3QLZA 3F0SX 3JWMA 4DPDA 3KFYA 1DLRA 3F8ZA 2W9GA 3Q1HA 3SRQX 3DRCA 4LAHX 4IXED 4M6KA 1DREA 3EEKA 3M09A 1BZFA 3FS6A 4EIGA 3TQ8A 4XT6A 1PD9A 3F0BX 4EILA 4KBNA 2BLBA 4ELHA 1DLSA 1SEJA 5JA3A 3UM6A 1J3KA 1RX7A 1S3UA 3FYWX
chains in the Genus database with same CATH superfamily
1CZ3A 2W9HA 1DR3A 1IA2A 1M79A 5ECCA 3EIGA 4M6LA 2FZJA 1ZDRA 1DF7A 3FQFA 4OSGA 4PTHA 3TQAA 2W3MA 4NX6A 3K47A 4PSYA 1D1GA 3ZPGA 1DR6A 1RX4A 3NXTA 1U70A 4XT8A 3SGYA 3CL9A 2P4GA 5ECXA 3S3VA 5CC9A 1DR2A 4M6JA 2W3BA 1RA9A 3NZCX 1DIUA 3N0HA 2GD9A 4P68A 3F0QX 3DL6A 4QJZD 3NU0A 4PDJA 1DYJA 3QG2A 4FGGA 5HSUA 2AZNA 4KL9A 1DG5A 4H98A 4KJLA 4X5HA 1DR5A 2BLAA 3QLWA 1QZFA 3K45A 3QLRA 1CD2A 1S3YA 1AOEA 4DFRA 3K74A 3FY9X 3DFRA 1RX9A 3S7AA 3TD8A 1DDRA 3IA5A 3FQ0A 4G95A 2B3ZA 2C2TA 3NTZA 3LG4A 1HFRA 1DRFA 1KMSA 1DRAA 3NXRA 2W3AA 3FRBX 3S9UA 2XW7A 4QLFA 2ITHA 1LUDA 3F0UX 1RX2A 7DFRA 3FL9A 1DYHA 3NXVA 1OHJA 3SA1A 3NXOA 5U27A 1PDBA 4KM2A 1RX8A 4PSTA 2DHFA 1DYRA 4P66A 3FYVX 4XT4A 3VCOA 3JWKA 5HT5A 2H2QA 3NRRA 1E26A 1DR4A 2BL9A 3R33A 3DG8A 3FREX 4KM0A 4KJJA 1DAJA 4PTJA 4XT7A 3SR5X 2C2SA 4DPHA 4X5GA 4LEKX 3SRUX 4FGHA 4XT5A 5HQYA 3FRFX 4HOGA 4QHVA 3IROA 4X5FA 3OAFA 1RC4A 3SRSX 3RO9A 3FQOA 3QYOA 1M7AA 3JWFA 1RX1A 1VJ3A 5DFRA 3D84X 1RG7A 1MVSA 1LY3A 2DRCA 4KNEA 3OCHA 2D0KA 3HBBA 3I8AX 4G8ZX 3K2HA 3NXYA 1RX6A 3QL0A 4KY4A 1DHIA 2CIGA 3FRAX 4CD2A 2HQPA 1DRHA 3JVXA 4OR7A 3NZ9X 3TQBA 1JUVA 1RA1A 3SRWX 4KAKA 4Q67A 3INVA 3SQYX 2FZIA 3F0VX 3QLSA 5U26A 1S3VA 4M7VA 3DATA 4HA7A 1BOZA 4X5JA 3JWCA 1U71A 3CD2A 3IRMA 3NZDA 4KD7A 1DHJA 1RB3A 4I1NA 4KFJA 4TU5X 4QI9A 1IA4A 3TQ9A 1J3IA 2HM9A 5HF2X 3NZBX 5HQZA 4Q0DA 2G6VA 3DL5A 1RX3A 1PD8A 3EX8A 1RE7A 4HOFA 3FY8X 4LAEX 3ZPCA 2W3WA 1J3JA 5EAJA 1RX5A 2HXVA 3F8YA 4NX7A 2W9SA 3KGYA 3FRDX 3NXXA 4IXFX 1HFPA 3L3RA 3UM5A 4P3RA 4HA9A 2OIPA 4Q0EA 3QLXA 1IA1A 1RB2A 4KJKA 5JG0X 4M7UA 1DRBA 4X5IA 3GHWA 3QLYA 8DFRA 3FQCA 1IA3A 1KLKA 1RA3A 4XECX 3KJRA 1RA8A 4H95A 2FZHA 4ELGA 4DDRA 1TDRA 1DDSA 4QJCA 3E0BA 2L28A 4KEBA 4Q6AA 2OBCA 3JW5A 1DG8A 3D80A 4KLXA 2LF1A 1AI9A 3NZ6X 3NZAX 3JSUA 3SRRX 1S3WA 3DAUA 3JW3A 3FL8A 5HI6A 1DISA 1RA2A 4H96A 1RH3A 3GHVA 4ECKA 4ELBA 3IRNA 3ROAA 5HVEA 1KMVA 3QGTA 1DR7A 2INQA 2W3VA 4HOEA 3RG9A 4PSSA 2JYBA 3F91A 1OHKA 5HSRA 4G3MA 4FHBA 3JTWA 3EEJA 5HT4A 3FQZA 2ANOA 4KY8A 5HVBA 1U72A 4EIZA 1M78A 3GI2A 3HJ3A 4ELEA 1RD7A 3CSEA 5HPBA 2O7PA 5HUIA 4LAGX 3CLBA 4RGCA 2QK8A 4H97A 3EELA 1RF7A 1YHOA 5HF0X 3SA2A 1MVTA 4P3QA 3QYLA 3IX9A 2KGKA 4DP3A 5DXVA 3QFXA 5FDAA 1DHFA 1DG7A 3SAIA 4M2XA 1JOLA 4ELFA 3IA4A 3QL3A 3FQVA 3M08A 6DFRA 2ZZAA 5CCCA 1DYIA 2BLCA 3UM8A 3I3RA 1AO8A 4IXGX 3KY8A 3DGAA 3SH2A 3GHCA 4GH8A 1JOMA 2CD2A 4QLEA 1VDRA 1LY4A 1HFQA 3GYFA 4QLGA 3F0XX 3EEMA 2ANQA 4XRBA 4EJ1A 3KJSA 4XE6X 2D5NA 1DR1A 2W9TA 4I13A 4KYAA 5E8QA 3QLZA 3F0SX 3JWMA 4DPDA 3KFYA 1DLRA 3F8ZA 2W9GA 3Q1HA 3SRQX 3DRCA 4LAHX 4IXED 4M6KA 1DREA 3EEKA 3M09A 1BZFA 3FS6A 4EIGA 3TQ8A 4XT6A 1PD9A 3F0BX 4EILA 4KBNA 2BLBA 4ELHA 1DLSA 1SEJA 5JA3A 3UM6A 1J3KA 1RX7A 1S3UA 3FYWX
chains in the Genus database with same CATH topology
1CZ3A 2W9HA 1DR3A 1IA2A 1M79A 5ECCA 3EIGA 4M6LA 2FZJA 1ZDRA 1DF7A 3FQFA 4OSGA 4PTHA 3TQAA 2W3MA 4NX6A 3K47A 4PSYA 1D1GA 3ZPGA 1DR6A 1RX4A 3NXTA 1U70A 4XT8A 3SGYA 3CL9A 2P4GA 5ECXA 3S3VA 5CC9A 1DR2A 4M6JA 2W3BA 1RA9A 3NZCX 1DIUA 3N0HA 2GD9A 4P68A 3F0QX 3DL6A 4QJZD 3NU0A 4PDJA 1DYJA 3QG2A 4FGGA 5HSUA 2AZNA 4KL9A 1DG5A 4H98A 4KJLA 4X5HA 1DR5A 2BLAA 3QLWA 1QZFA 3K45A 3QLRA 1CD2A 1S3YA 1AOEA 4DFRA 3K74A 3FY9X 3DFRA 1RX9A 3S7AA 3TD8A 1DDRA 3IA5A 3FQ0A 4G95A 2B3ZA 2C2TA 3NTZA 3LG4A 1HFRA 1DRFA 1KMSA 1DRAA 3NXRA 2W3AA 3FRBX 3S9UA 2XW7A 4QLFA 2ITHA 1LUDA 3F0UX 1RX2A 7DFRA 3FL9A 1DYHA 3NXVA 1OHJA 3SA1A 3NXOA 5U27A 1PDBA 4KM2A 1RX8A 4PSTA 2DHFA 1DYRA 4P66A 3FYVX 4XT4A 3VCOA 3JWKA 5HT5A 2H2QA 3NRRA 1E26A 1DR4A 2BL9A 3R33A 3DG8A 3FREX 4KM0A 4KJJA 1DAJA 4PTJA 4XT7A 3SR5X 2C2SA 4DPHA 4X5GA 4LEKX 3SRUX 4FGHA 4XT5A 5HQYA 3FRFX 4HOGA 4QHVA 3IROA 4X5FA 3OAFA 1RC4A 3SRSX 3RO9A 3FQOA 3QYOA 1M7AA 3JWFA 1RX1A 1VJ3A 5DFRA 3D84X 1RG7A 1MVSA 1LY3A 2DRCA 4KNEA 3OCHA 2D0KA 3HBBA 3I8AX 4G8ZX 3K2HA 3NXYA 1RX6A 3QL0A 4KY4A 1DHIA 2CIGA 3FRAX 4CD2A 2HQPA 1DRHA 3JVXA 4OR7A 3NZ9X 3TQBA 1JUVA 1RA1A 3SRWX 4KAKA 4Q67A 3INVA 3SQYX 2FZIA 3F0VX 3QLSA 5U26A 1S3VA 4M7VA 3DATA 4HA7A 1BOZA 4X5JA 3JWCA 1U71A 3CD2A 3IRMA 3NZDA 4KD7A 1DHJA 1RB3A 4I1NA 4KFJA 4TU5X 4QI9A 1IA4A 3TQ9A 1J3IA 2HM9A 5HF2X 3NZBX 5HQZA 4Q0DA 2G6VA 3DL5A 1RX3A 1PD8A 3EX8A 1RE7A 4HOFA 3FY8X 4LAEX 3ZPCA 2W3WA 1J3JA 5EAJA 1RX5A 2HXVA 3F8YA 4NX7A 2W9SA 3KGYA 3FRDX 3NXXA 4IXFX 1HFPA 3L3RA 3UM5A 4P3RA 4HA9A 2OIPA 4Q0EA 3QLXA 1IA1A 1RB2A 4KJKA 5JG0X 4M7UA 1DRBA 4X5IA 3GHWA 3QLYA 8DFRA 3FQCA 1IA3A 1KLKA 1RA3A 4XECX 3KJRA 1RA8A 4H95A 2FZHA 4ELGA 4DDRA 1TDRA 1DDSA 4QJCA 3E0BA 2L28A 4KEBA 4Q6AA 2OBCA 3JW5A 1DG8A 3D80A 4KLXA 2LF1A 1AI9A 3NZ6X 3NZAX 3JSUA 3SRRX 1S3WA 3DAUA 3JW3A 3FL8A 5HI6A 1DISA 1RA2A 4H96A 1RH3A 3GHVA 4ECKA 4ELBA 3IRNA 3ROAA 5HVEA 1KMVA 3QGTA 1DR7A 2INQA 2W3VA 4HOEA 3RG9A 4PSSA 2JYBA 3F91A 1OHKA 5HSRA 4G3MA 4FHBA 3JTWA 3EEJA 5HT4A 3FQZA 2ANOA 4KY8A 5HVBA 1U72A 4EIZA 1M78A 3GI2A 3HJ3A 4ELEA 1RD7A 3CSEA 5HPBA 2O7PA 5HUIA 4LAGX 3CLBA 4RGCA 2QK8A 4H97A 3EELA 1RF7A 1YHOA 5HF0X 3SA2A 1MVTA 4P3QA 3QYLA 3IX9A 2KGKA 4DP3A 5DXVA 3QFXA 5FDAA 1DHFA 1DG7A 3SAIA 4M2XA 1JOLA 4ELFA 3IA4A 3QL3A 3FQVA 3M08A 6DFRA 2ZZAA 5CCCA 1DYIA 2BLCA 3UM8A 3I3RA 1AO8A 4IXGX 3KY8A 3DGAA 3SH2A 3GHCA 4GH8A 1JOMA 2CD2A 4QLEA 1VDRA 1LY4A 1HFQA 3GYFA 4QLGA 3F0XX 3EEMA 2ANQA 4XRBA 4EJ1A 3KJSA 4XE6X 2D5NA 1DR1A 2W9TA 4I13A 4KYAA 5E8QA 3QLZA 3F0SX 3JWMA 4DPDA 3KFYA 1DLRA 3F8ZA 2W9GA 3Q1HA 3SRQX 3DRCA 4LAHX 4IXED 4M6KA 1DREA 3EEKA 3M09A 1BZFA 3FS6A 4EIGA 3TQ8A 4XT6A 1PD9A 3F0BX 4EILA 4KBNA 2BLBA 4ELHA 1DLSA 1SEJA 5JA3A 3UM6A 1J3KA 1RX7A 1S3UA 3FYWX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CZ3 A;  2W9H A;  1DR3 A;  1IA2 A;  1M79 A;  5ECC A;  3EIG A;  4M6L A;  2FZJ A;  1ZDR A;  1DF7 A;  3FQF A;  4OSG A;  4PTH A;  3TQA A;  2W3M A;  4NX6 A;  3K47 A;  4PSY A;  1D1G A;  3ZPG A;  1DR6 A;  1RX4 A;  3NXT A;  1U70 A;  4XT8 A;  3SGY A;  3CL9 A;  2P4G A;  5ECX A;  3S3V A;  5CC9 A;  1DR2 A;  4M6J A;  2W3B A;  1RA9 A;  3NZC X;  1DIU A;  3N0H A;  2GD9 A;  4P68 A;  3F0Q X;  3DL6 A;  4QJZ D;  3NU0 A;  4PDJ A;  1DYJ A;  3QG2 A;  4FGG A;  5HSU A;  2AZN A;  4KL9 A;  1DG5 A;  4H98 A;  4KJL A;  4X5H A;  1DR5 A;  2BLA A;  3QLW A;  1QZF A;  3K45 A;  3QLR A;  1CD2 A;  1S3Y A;  1AOE A;  4DFR A;  3K74 A;  3FY9 X;  3DFR A;  1RX9 A;  3S7A A;  3TD8 A;  1DDR A;  3IA5 A;  3FQ0 A;  4G95 A;  2B3Z A;  2C2T A;  3NTZ A;  3LG4 A;  1HFR A;  1DRF A;  1KMS A;  1DRA A;  3NXR A;  2W3A A;  3FRB X;  3S9U A;  2XW7 A;  4QLF A;  2ITH A;  1LUD A;  3F0U X;  1RX2 A;  7DFR A;  3FL9 A;  1DYH A;  3NXV A;  1OHJ A;  3SA1 A;  3NXO A;  5U27 A;  1PDB A;  4KM2 A;  1RX8 A;  4PST A;  2DHF A;  1DYR A;  4P66 A;  3FYV X;  4XT4 A;  3VCO A;  3JWK A;  5HT5 A;  2H2Q A;  3NRR A;  1E26 A;  1DR4 A;  2BL9 A;  3R33 A;  3DG8 A;  3FRE X;  4KM0 A;  4KJJ A;  1DAJ A;  4PTJ A;  4XT7 A;  3SR5 X;  2C2S A;  4DPH A;  4X5G A;  4LEK X;  3SRU X;  4FGH A;  4XT5 A;  5HQY A;  3FRF X;  4HOG A;  4QHV A;  3IRO A;  4X5F A;  3OAF A;  1RC4 A;  3SRS X;  3RO9 A;  3FQO A;  3QYO A;  1M7A A;  3JWF A;  1RX1 A;  1VJ3 A;  5DFR A;  3D84 X;  1RG7 A;  1MVS A;  1LY3 A;  2DRC A;  4KNE A;  3OCH A;  2D0K A;  3HBB A;  3I8A X;  4G8Z X;  3K2H A;  3NXY A;  1RX6 A;  3QL0 A;  4KY4 A;  1DHI A;  2CIG A;  3FRA X;  4CD2 A;  2HQP A;  1DRH A;  3JVX A;  4OR7 A;  3NZ9 X;  3TQB A;  1JUV A;  1RA1 A;  3SRW X;  4KAK A;  4Q67 A;  3INV A;  3SQY X;  2FZI A;  3F0V X;  3QLS A;  5U26 A;  1S3V A;  4M7V A;  3DAT A;  4HA7 A;  1BOZ A;  4X5J A;  3JWC A;  1U71 A;  3CD2 A;  3IRM A;  3NZD A;  4KD7 A;  1DHJ A;  1RB3 A;  4I1N A;  4KFJ A;  4TU5 X;  4QI9 A;  1IA4 A;  3TQ9 A;  1J3I A;  2HM9 A;  5HF2 X;  3NZB X;  5HQZ A;  4Q0D A;  2G6V A;  3DL5 A;  1RX3 A;  1PD8 A;  3EX8 A;  1RE7 A;  4HOF A;  3FY8 X;  4LAE X;  3ZPC A;  2W3W A;  1J3J A;  5EAJ A;  1RX5 A;  2HXV A;  3F8Y A;  4NX7 A;  2W9S A;  3KGY A;  3FRD X;  3NXX A;  4IXF X;  1HFP A;  3L3R A;  3UM5 A;  4P3R A;  4HA9 A;  2OIP A;  4Q0E A;  3QLX A;  1IA1 A;  1RB2 A;  4KJK A;  5JG0 X;  4M7U A;  1DRB A;  4X5I A;  3GHW A;  3QLY A;  8DFR A;  3FQC A;  1IA3 A;  1KLK A;  1RA3 A;  4XEC X;  3KJR A;  1RA8 A;  4H95 A;  2FZH A;  4ELG A;  4DDR A;  1TDR A;  1DDS A;  4QJC A;  3E0B A;  2L28 A;  4KEB A;  4Q6A A;  2OBC A;  3JW5 A;  1DG8 A;  3D80 A;  4KLX A;  2LF1 A;  1AI9 A;  3NZ6 X;  3NZA X;  3JSU A;  3SRR X;  1S3W A;  3DAU A;  3JW3 A;  3FL8 A;  5HI6 A;  1DIS A;  1RA2 A;  4H96 A;  1RH3 A;  3GHV A;  4ECK A;  4ELB A;  3IRN A;  3ROA A;  5HVE A;  1KMV A;  3QGT A;  1DR7 A;  2INQ A;  2W3V A;  4HOE A;  3RG9 A;  4PSS A;  2JYB A;  3F91 A;  1OHK A;  5HSR A;  4G3M A;  4FHB A;  3JTW A;  3EEJ A;  5HT4 A;  3FQZ A;  2ANO A;  4KY8 A;  5HVB A;  1U72 A;  4EIZ A;  1M78 A;  3GI2 A;  3HJ3 A;  4ELE A;  1RD7 A;  3CSE A;  5HPB A;  2O7P A;  5HUI A;  4LAG X;  3CLB A;  4RGC A;  2QK8 A;  4H97 A;  3EEL A;  1RF7 A;  1YHO A;  5HF0 X;  3SA2 A;  1MVT A;  4P3Q A;  3QYL A;  3IX9 A;  2KGK A;  4DP3 A;  5DXV A;  3QFX A;  5FDA A;  1DHF A;  1DG7 A;  3SAI A;  4M2X A;  1JOL A;  4ELF A;  3IA4 A;  3QL3 A;  3FQV A;  3M08 A;  6DFR A;  2ZZA A;  5CCC A;  1DYI A;  2BLC A;  3UM8 A;  3I3R A;  1AO8 A;  4IXG X;  3KY8 A;  3DGA A;  3SH2 A;  3GHC A;  4GH8 A;  1JOM A;  2CD2 A;  4QLE A;  1VDR A;  1LY4 A;  1HFQ A;  3GYF A;  4QLG A;  3F0X X;  3EEM A;  2ANQ A;  4XRB A;  4EJ1 A;  3KJS A;  4XE6 X;  2D5N A;  1DR1 A;  2W9T A;  4I13 A;  4KYA A;  5E8Q A;  3QLZ A;  3F0S X;  3JWM A;  4DPD A;  3KFY A;  1DLR A;  3F8Z A;  2W9G A;  3Q1H A;  3SRQ X;  3DRC A;  4LAH X;  4IXE D;  4M6K A;  1DRE A;  3EEK A;  3M09 A;  1BZF A;  3FS6 A;  4EIG A;  3TQ8 A;  4XT6 A;  1PD9 A;  3F0B X;  4EIL A;  4KBN A;  2BLB A;  4ELH A;  1DLS A;  1SEJ A;  5JA3 A;  3UM6 A;  1J3K A;  1RX7 A;  1S3U A;  3FYW X; 
#chains in the Genus database with same CATH topology
 1CZ3 A;  2W9H A;  1DR3 A;  1IA2 A;  1M79 A;  5ECC A;  3EIG A;  4M6L A;  2FZJ A;  1ZDR A;  1DF7 A;  3FQF A;  4OSG A;  4PTH A;  3TQA A;  2W3M A;  4NX6 A;  3K47 A;  4PSY A;  1D1G A;  3ZPG A;  1DR6 A;  1RX4 A;  3NXT A;  1U70 A;  4XT8 A;  3SGY A;  3CL9 A;  2P4G A;  5ECX A;  3S3V A;  5CC9 A;  1DR2 A;  4M6J A;  2W3B A;  1RA9 A;  3NZC X;  1DIU A;  3N0H A;  2GD9 A;  4P68 A;  3F0Q X;  3DL6 A;  4QJZ D;  3NU0 A;  4PDJ A;  1DYJ A;  3QG2 A;  4FGG A;  5HSU A;  2AZN A;  4KL9 A;  1DG5 A;  4H98 A;  4KJL A;  4X5H A;  1DR5 A;  2BLA A;  3QLW A;  1QZF A;  3K45 A;  3QLR A;  1CD2 A;  1S3Y A;  1AOE A;  4DFR A;  3K74 A;  3FY9 X;  3DFR A;  1RX9 A;  3S7A A;  3TD8 A;  1DDR A;  3IA5 A;  3FQ0 A;  4G95 A;  2B3Z A;  2C2T A;  3NTZ A;  3LG4 A;  1HFR A;  1DRF A;  1KMS A;  1DRA A;  3NXR A;  2W3A A;  3FRB X;  3S9U A;  2XW7 A;  4QLF A;  2ITH A;  1LUD A;  3F0U X;  1RX2 A;  7DFR A;  3FL9 A;  1DYH A;  3NXV A;  1OHJ A;  3SA1 A;  3NXO A;  5U27 A;  1PDB A;  4KM2 A;  1RX8 A;  4PST A;  2DHF A;  1DYR A;  4P66 A;  3FYV X;  4XT4 A;  3VCO A;  3JWK A;  5HT5 A;  2H2Q A;  3NRR A;  1E26 A;  1DR4 A;  2BL9 A;  3R33 A;  3DG8 A;  3FRE X;  4KM0 A;  4KJJ A;  1DAJ A;  4PTJ A;  4XT7 A;  3SR5 X;  2C2S A;  4DPH A;  4X5G A;  4LEK X;  3SRU X;  4FGH A;  4XT5 A;  5HQY A;  3FRF X;  4HOG A;  4QHV A;  3IRO A;  4X5F A;  3OAF A;  1RC4 A;  3SRS X;  3RO9 A;  3FQO A;  3QYO A;  1M7A A;  3JWF A;  1RX1 A;  1VJ3 A;  5DFR A;  3D84 X;  1RG7 A;  1MVS A;  1LY3 A;  2DRC A;  4KNE A;  3OCH A;  2D0K A;  3HBB A;  3I8A X;  4G8Z X;  3K2H A;  3NXY A;  1RX6 A;  3QL0 A;  4KY4 A;  1DHI A;  2CIG A;  3FRA X;  4CD2 A;  2HQP A;  1DRH A;  3JVX A;  4OR7 A;  3NZ9 X;  3TQB A;  1JUV A;  1RA1 A;  3SRW X;  4KAK A;  4Q67 A;  3INV A;  3SQY X;  2FZI A;  3F0V X;  3QLS A;  5U26 A;  1S3V A;  4M7V A;  3DAT A;  4HA7 A;  1BOZ A;  4X5J A;  3JWC A;  1U71 A;  3CD2 A;  3IRM A;  3NZD A;  4KD7 A;  1DHJ A;  1RB3 A;  4I1N A;  4KFJ A;  4TU5 X;  4QI9 A;  1IA4 A;  3TQ9 A;  1J3I A;  2HM9 A;  5HF2 X;  3NZB X;  5HQZ A;  4Q0D A;  2G6V A;  3DL5 A;  1RX3 A;  1PD8 A;  3EX8 A;  1RE7 A;  4HOF A;  3FY8 X;  4LAE X;  3ZPC A;  2W3W A;  1J3J A;  5EAJ A;  1RX5 A;  2HXV A;  3F8Y A;  4NX7 A;  2W9S A;  3KGY A;  3FRD X;  3NXX A;  4IXF X;  1HFP A;  3L3R A;  3UM5 A;  4P3R A;  4HA9 A;  2OIP A;  4Q0E A;  3QLX A;  1IA1 A;  1RB2 A;  4KJK A;  5JG0 X;  4M7U A;  1DRB A;  4X5I A;  3GHW A;  3QLY A;  8DFR A;  3FQC A;  1IA3 A;  1KLK A;  1RA3 A;  4XEC X;  3KJR A;  1RA8 A;  4H95 A;  2FZH A;  4ELG A;  4DDR A;  1TDR A;  1DDS A;  4QJC A;  3E0B A;  2L28 A;  4KEB A;  4Q6A A;  2OBC A;  3JW5 A;  1DG8 A;  3D80 A;  4KLX A;  2LF1 A;  1AI9 A;  3NZ6 X;  3NZA X;  3JSU A;  3SRR X;  1S3W A;  3DAU A;  3JW3 A;  3FL8 A;  5HI6 A;  1DIS A;  1RA2 A;  4H96 A;  1RH3 A;  3GHV A;  4ECK A;  4ELB A;  3IRN A;  3ROA A;  5HVE A;  1KMV A;  3QGT A;  1DR7 A;  2INQ A;  2W3V A;  4HOE A;  3RG9 A;  4PSS A;  2JYB A;  3F91 A;  1OHK A;  5HSR A;  4G3M A;  4FHB A;  3JTW A;  3EEJ A;  5HT4 A;  3FQZ A;  2ANO A;  4KY8 A;  5HVB A;  1U72 A;  4EIZ A;  1M78 A;  3GI2 A;  3HJ3 A;  4ELE A;  1RD7 A;  3CSE A;  5HPB A;  2O7P A;  5HUI A;  4LAG X;  3CLB A;  4RGC A;  2QK8 A;  4H97 A;  3EEL A;  1RF7 A;  1YHO A;  5HF0 X;  3SA2 A;  1MVT A;  4P3Q A;  3QYL A;  3IX9 A;  2KGK A;  4DP3 A;  5DXV A;  3QFX A;  5FDA A;  1DHF A;  1DG7 A;  3SAI A;  4M2X A;  1JOL A;  4ELF A;  3IA4 A;  3QL3 A;  3FQV A;  3M08 A;  6DFR A;  2ZZA A;  5CCC A;  1DYI A;  2BLC A;  3UM8 A;  3I3R A;  1AO8 A;  4IXG X;  3KY8 A;  3DGA A;  3SH2 A;  3GHC A;  4GH8 A;  1JOM A;  2CD2 A;  4QLE A;  1VDR A;  1LY4 A;  1HFQ A;  3GYF A;  4QLG A;  3F0X X;  3EEM A;  2ANQ A;  4XRB A;  4EJ1 A;  3KJS A;  4XE6 X;  2D5N A;  1DR1 A;  2W9T A;  4I13 A;  4KYA A;  5E8Q A;  3QLZ A;  3F0S X;  3JWM A;  4DPD A;  3KFY A;  1DLR A;  3F8Z A;  2W9G A;  3Q1H A;  3SRQ X;  3DRC A;  4LAH X;  4IXE D;  4M6K A;  1DRE A;  3EEK A;  3M09 A;  1BZF A;  3FS6 A;  4EIG A;  3TQ8 A;  4XT6 A;  1PD9 A;  3F0B X;  4EIL A;  4KBN A;  2BLB A;  4ELH A;  1DLS A;  1SEJ A;  5JA3 A;  3UM6 A;  1J3K A;  1RX7 A;  1S3U A;  3FYW X; 
#chains in the Genus database with same CATH homology
 1CZ3 A;  2W9H A;  1DR3 A;  1IA2 A;  1M79 A;  5ECC A;  3EIG A;  4M6L A;  2FZJ A;  1ZDR A;  1DF7 A;  3FQF A;  4OSG A;  4PTH A;  3TQA A;  2W3M A;  4NX6 A;  3K47 A;  4PSY A;  1D1G A;  3ZPG A;  1DR6 A;  1RX4 A;  3NXT A;  1U70 A;  4XT8 A;  3SGY A;  3CL9 A;  2P4G A;  5ECX A;  3S3V A;  5CC9 A;  1DR2 A;  4M6J A;  2W3B A;  1RA9 A;  3NZC X;  1DIU A;  3N0H A;  2GD9 A;  4P68 A;  3F0Q X;  3DL6 A;  4QJZ D;  3NU0 A;  4PDJ A;  1DYJ A;  3QG2 A;  4FGG A;  5HSU A;  2AZN A;  4KL9 A;  1DG5 A;  4H98 A;  4KJL A;  4X5H A;  1DR5 A;  2BLA A;  3QLW A;  1QZF A;  3K45 A;  3QLR A;  1CD2 A;  1S3Y A;  1AOE A;  4DFR A;  3K74 A;  3FY9 X;  3DFR A;  1RX9 A;  3S7A A;  3TD8 A;  1DDR A;  3IA5 A;  3FQ0 A;  4G95 A;  2B3Z A;  2C2T A;  3NTZ A;  3LG4 A;  1HFR A;  1DRF A;  1KMS A;  1DRA A;  3NXR A;  2W3A A;  3FRB X;  3S9U A;  2XW7 A;  4QLF A;  2ITH A;  1LUD A;  3F0U X;  1RX2 A;  7DFR A;  3FL9 A;  1DYH A;  3NXV A;  1OHJ A;  3SA1 A;  3NXO A;  5U27 A;  1PDB A;  4KM2 A;  1RX8 A;  4PST A;  2DHF A;  1DYR A;  4P66 A;  3FYV X;  4XT4 A;  3VCO A;  3JWK A;  5HT5 A;  2H2Q A;  3NRR A;  1E26 A;  1DR4 A;  2BL9 A;  3R33 A;  3DG8 A;  3FRE X;  4KM0 A;  4KJJ A;  1DAJ A;  4PTJ A;  4XT7 A;  3SR5 X;  2C2S A;  4DPH A;  4X5G A;  4LEK X;  3SRU X;  4FGH A;  4XT5 A;  5HQY A;  3FRF X;  4HOG A;  4QHV A;  3IRO A;  4X5F A;  3OAF A;  1RC4 A;  3SRS X;  3RO9 A;  3FQO A;  3QYO A;  1M7A A;  3JWF A;  1RX1 A;  1VJ3 A;  5DFR A;  3D84 X;  1RG7 A;  1MVS A;  1LY3 A;  2DRC A;  4KNE A;  3OCH A;  2D0K A;  3HBB A;  3I8A X;  4G8Z X;  3K2H A;  3NXY A;  1RX6 A;  3QL0 A;  4KY4 A;  1DHI A;  2CIG A;  3FRA X;  4CD2 A;  2HQP A;  1DRH A;  3JVX A;  4OR7 A;  3NZ9 X;  3TQB A;  1JUV A;  1RA1 A;  3SRW X;  4KAK A;  4Q67 A;  3INV A;  3SQY X;  2FZI A;  3F0V X;  3QLS A;  5U26 A;  1S3V A;  4M7V A;  3DAT A;  4HA7 A;  1BOZ A;  4X5J A;  3JWC A;  1U71 A;  3CD2 A;  3IRM A;  3NZD A;  4KD7 A;  1DHJ A;  1RB3 A;  4I1N A;  4KFJ A;  4TU5 X;  4QI9 A;  1IA4 A;  3TQ9 A;  1J3I A;  2HM9 A;  5HF2 X;  3NZB X;  5HQZ A;  4Q0D A;  2G6V A;  3DL5 A;  1RX3 A;  1PD8 A;  3EX8 A;  1RE7 A;  4HOF A;  3FY8 X;  4LAE X;  3ZPC A;  2W3W A;  1J3J A;  5EAJ A;  1RX5 A;  2HXV A;  3F8Y A;  4NX7 A;  2W9S A;  3KGY A;  3FRD X;  3NXX A;  4IXF X;  1HFP A;  3L3R A;  3UM5 A;  4P3R A;  4HA9 A;  2OIP A;  4Q0E A;  3QLX A;  1IA1 A;  1RB2 A;  4KJK A;  5JG0 X;  4M7U A;  1DRB A;  4X5I A;  3GHW A;  3QLY A;  8DFR A;  3FQC A;  1IA3 A;  1KLK A;  1RA3 A;  4XEC X;  3KJR A;  1RA8 A;  4H95 A;  2FZH A;  4ELG A;  4DDR A;  1TDR A;  1DDS A;  4QJC A;  3E0B A;  2L28 A;  4KEB A;  4Q6A A;  2OBC A;  3JW5 A;  1DG8 A;  3D80 A;  4KLX A;  2LF1 A;  1AI9 A;  3NZ6 X;  3NZA X;  3JSU A;  3SRR X;  1S3W A;  3DAU A;  3JW3 A;  3FL8 A;  5HI6 A;  1DIS A;  1RA2 A;  4H96 A;  1RH3 A;  3GHV A;  4ECK A;  4ELB A;  3IRN A;  3ROA A;  5HVE A;  1KMV A;  3QGT A;  1DR7 A;  2INQ A;  2W3V A;  4HOE A;  3RG9 A;  4PSS A;  2JYB A;  3F91 A;  1OHK A;  5HSR A;  4G3M A;  4FHB A;  3JTW A;  3EEJ A;  5HT4 A;  3FQZ A;  2ANO A;  4KY8 A;  5HVB A;  1U72 A;  4EIZ A;  1M78 A;  3GI2 A;  3HJ3 A;  4ELE A;  1RD7 A;  3CSE A;  5HPB A;  2O7P A;  5HUI A;  4LAG X;  3CLB A;  4RGC A;  2QK8 A;  4H97 A;  3EEL A;  1RF7 A;  1YHO A;  5HF0 X;  3SA2 A;  1MVT A;  4P3Q A;  3QYL A;  3IX9 A;  2KGK A;  4DP3 A;  5DXV A;  3QFX A;  5FDA A;  1DHF A;  1DG7 A;  3SAI A;  4M2X A;  1JOL A;  4ELF A;  3IA4 A;  3QL3 A;  3FQV A;  3M08 A;  6DFR A;  2ZZA A;  5CCC A;  1DYI A;  2BLC A;  3UM8 A;  3I3R A;  1AO8 A;  4IXG X;  3KY8 A;  3DGA A;  3SH2 A;  3GHC A;  4GH8 A;  1JOM A;  2CD2 A;  4QLE A;  1VDR A;  1LY4 A;  1HFQ A;  3GYF A;  4QLG A;  3F0X X;  3EEM A;  2ANQ A;  4XRB A;  4EJ1 A;  3KJS A;  4XE6 X;  2D5N A;  1DR1 A;  2W9T A;  4I13 A;  4KYA A;  5E8Q A;  3QLZ A;  3F0S X;  3JWM A;  4DPD A;  3KFY A;  1DLR A;  3F8Z A;  2W9G A;  3Q1H A;  3SRQ X;  3DRC A;  4LAH X;  4IXE D;  4M6K A;  1DRE A;  3EEK A;  3M09 A;  1BZF A;  3FS6 A;  4EIG A;  3TQ8 A;  4XT6 A;  1PD9 A;  3F0B X;  4EIL A;  4KBN A;  2BLB A;  4ELH A;  1DLS A;  1SEJ A;  5JA3 A;  3UM6 A;  1J3K A;  1RX7 A;  1S3U A;  3FYW X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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