1RA2A

Dihydrofolate reductase complexed with folate and nicotinamide adenine dinucleotide phosphate (oxidized form)
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 42
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1996-10-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1ra2A00
3M09A 4P66A 3FQ0A 4XT8A 2W9TA 4HOGA 5HQZA 3N0HA 4ELHA 4NX6A 1PD9A 3FRBX 1M79A 2BLBA 1IA4A 3NXYA 3QG2A 1DF7A 4P68A 5HT4A 1DR4A 3GHVA 2ANOA 3NXXA 1DAJA 5JA3A 4LAGX 3F0BX 3NU0A 5HI6A 3JWCA 4XE6X 2GD9A 3NZAX 3EEJA 3JVXA 4FHBA 1RX8A 3SR5X 1RX4A 3FQZA 1HFPA 3QYOA 3GHCA 2D5NA 3Q1HA 1M78A 2ZZAA 3UM6A 4KY8A 5HF0X 3FQOA 1LY4A 3KJRA 3KJSA 1RX3A 4M6KA 1DHIA 4X5FA 1S3YA 3QFXA 4XT7A 1DRFA 1MVTA 4KJLA 3QLSA 4H98A 4QJZD 4EJ1A 3IX9A 5HUIA 5DXVA 1DG7A 7DFRA 2C2TA 1S3VA 3SGYA 3QL3A 2LF1A 3K45A 1RX6A 3NTZA 2KGKA 2CIGA 1HFQA 3FQVA 4XECX 4PSYA 3QYLA 2W9HA 5DFRA 4HA9A 4KAKA 3QLXA 2W3AA 3F0SX 3IRMA 2INQA 1RX1A 3DGAA 3DATA 1RA3A 2CD2A 1DRHA 3EEMA 3FRAX 5CC9A 5EAJA 3DL6A 1DIUA 4QLGA 3I8AX 1DR1A 1CD2A 1PD8A 3SA1A 1KMSA 3QGTA 2FZIA 4I1NA 1IA2A 4QLEA 3F0XX 1DLRA 2OIPA 3JSUA 3JW3A 4PSTA 1RX5A 3QL0A 4FGGA 2QK8A 4QJCA 4X5JA 2BLAA 3R33A 3KGYA 5HSRA 1BOZA 3NXRA 5U27A 4LAEX 1RA9A 1DYRA 1JUVA 3JWMA 1DDRA 3K2HA 2P4GA 3K47A 3KY8A 1DYIA 4EIZA 2W3BA 5E8QA 3NZCX 4Q0EA 3F8YA 1RH3A 3FYVX 3NZDA 2FZHA 2W3VA 1RX7A 4KBNA 4P3QA 4EILA 3CLBA 4ELEA 4G8ZX 4Q0DA 3IRNA 2C2SA 4PTHA 4M6JA 1U71A 4KL9A 1PDBA 5HF2X 3NRRA 1RD7A 4HA7A 1DLSA 2HXVA 4KFJA 4KJJA 3QLWA 4OSGA 2W3MA 4QLFA 3FREX 3GI2A 2DRCA 3EIGA 3OAFA 4IXFX 1VDRA 3D80A 3INVA 1OHKA 3F91A 1S3UA 1RA8A 3FYWX 4G95A 4P3RA 4KLXA 1E26A 1ZDRA 3F0VX 4KM0A 3RG9A 3QLRA 3ZPCA 3LG4A 3UM8A 2FZJA 4KYAA 3I3RA 4PTJA 3QLYA 4XT6A 1HFRA 4DPDA 4PDJA 1MVSA 1JOLA 3FL8A 1RA2A 3QLZA 3TD8A 2H2QA 5HSUA 1RA1A 2ITHA 3FL9A 3VCOA 4EIGA 1JOMA 4IXGX 8DFRA 1LUDA 1AOEA 1DG8A 3L3RA 4KD7A 1AO8A 1DR3A 4LAHX 4I13A 5FDAA 1U70A 1KMVA 1J3IA 3IA5A 3DG8A 3TQ8A 4M2XA 1RG7A 1RB2A 4XT5A 1RE7A 3EEKA 1DISA 1DYJA 1U72A 4H97A 3JTWA 4H96A 3TQBA 4FGHA 3KFYA 3NXOA 4KY4A 3JWKA 3UM5A 2AZNA 4HOFA 3OCHA 3NXVA 1DREA 3DAUA 5JG0X 2O7PA 5U26A 3JW5A 1QZFA 3K74A 1J3JA 1DDSA 4NX7A 3SQYX 3SRRX 3CL9A 2BLCA 3FQCA 4DFRA 4ELGA 3F0QX 3FS6A 3FRFX 1RX2A 3IROA 2XW7A 2OBCA 4H95A 3CSEA 3S7AA 2L28A 3FQFA 3E0BA 1D1GA 1DRAA 4CD2A 4KEBA 4X5GA 3DL5A 4DPHA 1DHJA 1DR2A 3NXTA 1BZFA 4M6LA 3SRQX 4M7VA 3EX8A 4QI9A 1RX9A 3NZ6X 4KM2A 3HJ3A 3FY8X 1OHJA 3SRWX 2D0KA 1DG5A 3FRDX 4KJKA 4ELFA 2G6VA 4X5HA 5ECCA 4HOEA 3SH2A 1YHOA 1M7AA 3NZBX 3DFRA 3SRUX 3S3VA 1LY3A 1CZ3A 2W9SA 4XT4A 1KLKA 3ROAA 3HBBA 3CD2A 3SA2A 3D84X 6DFRA 3DRCA 1DYHA 3FY9X 4QHVA 3NZ9X 2DHFA 4X5IA 3GYFA 1DR6A 4ECKA 1TDRA 3GHWA 4LEKX 3EELA 2BL9A 4DP3A 1AI9A 2B3ZA 4M7UA 3SRSX 1DR7A 2ANQA 5HT5A 4Q67A 1J3KA 1VJ3A 5HPBA 1IA3A 4G3MA 2HQPA 3JWFA 4RGCA 4GH8A 3F8ZA 5ECXA 2HM9A 4KNEA 4PSSA 4DDRA 1DHFA 3F0UX 4IXED 4TU5X 1RC4A 1RF7A 3SAIA 4Q6AA 5CCCA 5HVBA 1S3WA 4XRBA 3TQAA 1RB3A 2W3WA 3ZPGA 1IA1A 1SEJA 3M08A 2JYBA 1DR5A 3RO9A 3TQ9A 3IA4A 5HVEA 4OR7A 3S9UA 2W9GA 5HQYA 1DRBA 4ELBA
chains in the Genus database with same CATH superfamily
3M09A 4P66A 3FQ0A 4XT8A 2W9TA 4HOGA 5HQZA 3N0HA 4ELHA 4NX6A 1PD9A 3FRBX 1M79A 2BLBA 1IA4A 3NXYA 3QG2A 1DF7A 4P68A 5HT4A 1DR4A 3GHVA 2ANOA 3NXXA 1DAJA 5JA3A 4LAGX 3F0BX 3NU0A 5HI6A 3JWCA 4XE6X 2GD9A 3NZAX 3EEJA 3JVXA 4FHBA 1RX8A 3SR5X 1RX4A 3FQZA 1HFPA 3QYOA 3GHCA 2D5NA 3Q1HA 1M78A 2ZZAA 3UM6A 4KY8A 5HF0X 3FQOA 1LY4A 3KJRA 3KJSA 1RX3A 4M6KA 1DHIA 4X5FA 1S3YA 3QFXA 4XT7A 1DRFA 1MVTA 4KJLA 3QLSA 4H98A 4QJZD 4EJ1A 3IX9A 5HUIA 5DXVA 1DG7A 7DFRA 2C2TA 1S3VA 3SGYA 3QL3A 2LF1A 3K45A 1RX6A 3NTZA 2KGKA 2CIGA 1HFQA 3FQVA 4XECX 4PSYA 3QYLA 2W9HA 5DFRA 4HA9A 4KAKA 3QLXA 2W3AA 3F0SX 3IRMA 2INQA 1RX1A 3DGAA 3DATA 1RA3A 2CD2A 1DRHA 3EEMA 3FRAX 5CC9A 5EAJA 3DL6A 1DIUA 4QLGA 3I8AX 1DR1A 1CD2A 1PD8A 3SA1A 1KMSA 3QGTA 2FZIA 4I1NA 1IA2A 4QLEA 3F0XX 1DLRA 2OIPA 3JSUA 3JW3A 4PSTA 1RX5A 3QL0A 4FGGA 2QK8A 4QJCA 4X5JA 2BLAA 3R33A 3KGYA 5HSRA 1BOZA 3NXRA 5U27A 4LAEX 1RA9A 1DYRA 1JUVA 3JWMA 1DDRA 3K2HA 2P4GA 3K47A 3KY8A 1DYIA 4EIZA 2W3BA 5E8QA 3NZCX 4Q0EA 3F8YA 1RH3A 3FYVX 3NZDA 2FZHA 2W3VA 1RX7A 4KBNA 4P3QA 4EILA 3CLBA 4ELEA 4G8ZX 4Q0DA 3IRNA 2C2SA 4PTHA 4M6JA 1U71A 4KL9A 1PDBA 5HF2X 3NRRA 1RD7A 4HA7A 1DLSA 2HXVA 4KFJA 4KJJA 3QLWA 4OSGA 2W3MA 4QLFA 3FREX 3GI2A 2DRCA 3EIGA 3OAFA 4IXFX 1VDRA 3D80A 3INVA 1OHKA 3F91A 1S3UA 1RA8A 3FYWX 4G95A 4P3RA 4KLXA 1E26A 1ZDRA 3F0VX 4KM0A 3RG9A 3QLRA 3ZPCA 3LG4A 3UM8A 2FZJA 4KYAA 3I3RA 4PTJA 3QLYA 4XT6A 1HFRA 4DPDA 4PDJA 1MVSA 1JOLA 3FL8A 1RA2A 3QLZA 3TD8A 2H2QA 5HSUA 1RA1A 2ITHA 3FL9A 3VCOA 4EIGA 1JOMA 4IXGX 8DFRA 1LUDA 1AOEA 1DG8A 3L3RA 4KD7A 1AO8A 1DR3A 4LAHX 4I13A 5FDAA 1U70A 1KMVA 1J3IA 3IA5A 3DG8A 3TQ8A 4M2XA 1RG7A 1RB2A 4XT5A 1RE7A 3EEKA 1DISA 1DYJA 1U72A 4H97A 3JTWA 4H96A 3TQBA 4FGHA 3KFYA 3NXOA 4KY4A 3JWKA 3UM5A 2AZNA 4HOFA 3OCHA 3NXVA 1DREA 3DAUA 5JG0X 2O7PA 5U26A 3JW5A 1QZFA 3K74A 1J3JA 1DDSA 4NX7A 3SQYX 3SRRX 3CL9A 2BLCA 3FQCA 4DFRA 4ELGA 3F0QX 3FS6A 3FRFX 1RX2A 3IROA 2XW7A 2OBCA 4H95A 3CSEA 3S7AA 2L28A 3FQFA 3E0BA 1D1GA 1DRAA 4CD2A 4KEBA 4X5GA 3DL5A 4DPHA 1DHJA 1DR2A 3NXTA 1BZFA 4M6LA 3SRQX 4M7VA 3EX8A 4QI9A 1RX9A 3NZ6X 4KM2A 3HJ3A 3FY8X 1OHJA 3SRWX 2D0KA 1DG5A 3FRDX 4KJKA 4ELFA 2G6VA 4X5HA 5ECCA 4HOEA 3SH2A 1YHOA 1M7AA 3NZBX 3DFRA 3SRUX 3S3VA 1LY3A 1CZ3A 2W9SA 4XT4A 1KLKA 3ROAA 3HBBA 3CD2A 3SA2A 3D84X 6DFRA 3DRCA 1DYHA 3FY9X 4QHVA 3NZ9X 2DHFA 4X5IA 3GYFA 1DR6A 4ECKA 1TDRA 3GHWA 4LEKX 3EELA 2BL9A 4DP3A 1AI9A 2B3ZA 4M7UA 3SRSX 1DR7A 2ANQA 5HT5A 4Q67A 1J3KA 1VJ3A 5HPBA 1IA3A 4G3MA 2HQPA 3JWFA 4RGCA 4GH8A 3F8ZA 5ECXA 2HM9A 4KNEA 4PSSA 4DDRA 1DHFA 3F0UX 4IXED 4TU5X 1RC4A 1RF7A 3SAIA 4Q6AA 5CCCA 5HVBA 1S3WA 4XRBA 3TQAA 1RB3A 2W3WA 3ZPGA 1IA1A 1SEJA 3M08A 2JYBA 1DR5A 3RO9A 3TQ9A 3IA4A 5HVEA 4OR7A 3S9UA 2W9GA 5HQYA 1DRBA 4ELBA
chains in the Genus database with same CATH topology
3M09A 4P66A 3FQ0A 4XT8A 2W9TA 4HOGA 5HQZA 3N0HA 4ELHA 4NX6A 1PD9A 3FRBX 1M79A 2BLBA 1IA4A 3NXYA 3QG2A 1DF7A 4P68A 5HT4A 1DR4A 3GHVA 2ANOA 3NXXA 1DAJA 5JA3A 4LAGX 3F0BX 3NU0A 5HI6A 3JWCA 4XE6X 2GD9A 3NZAX 3EEJA 3JVXA 4FHBA 1RX8A 3SR5X 1RX4A 3FQZA 1HFPA 3QYOA 3GHCA 2D5NA 3Q1HA 1M78A 2ZZAA 3UM6A 4KY8A 5HF0X 3FQOA 1LY4A 3KJRA 3KJSA 1RX3A 4M6KA 1DHIA 4X5FA 1S3YA 3QFXA 4XT7A 1DRFA 1MVTA 4KJLA 3QLSA 4H98A 4QJZD 4EJ1A 3IX9A 5HUIA 5DXVA 1DG7A 7DFRA 2C2TA 1S3VA 3SGYA 3QL3A 2LF1A 3K45A 1RX6A 3NTZA 2KGKA 2CIGA 1HFQA 3FQVA 4XECX 4PSYA 3QYLA 2W9HA 5DFRA 4HA9A 4KAKA 3QLXA 2W3AA 3F0SX 3IRMA 2INQA 1RX1A 3DGAA 3DATA 1RA3A 2CD2A 1DRHA 3EEMA 3FRAX 5CC9A 5EAJA 3DL6A 1DIUA 4QLGA 3I8AX 1DR1A 1CD2A 1PD8A 3SA1A 1KMSA 3QGTA 2FZIA 4I1NA 1IA2A 4QLEA 3F0XX 1DLRA 2OIPA 3JSUA 3JW3A 4PSTA 1RX5A 3QL0A 4FGGA 2QK8A 4QJCA 4X5JA 2BLAA 3R33A 3KGYA 5HSRA 1BOZA 3NXRA 5U27A 4LAEX 1RA9A 1DYRA 1JUVA 3JWMA 1DDRA 3K2HA 2P4GA 3K47A 3KY8A 1DYIA 4EIZA 2W3BA 5E8QA 3NZCX 4Q0EA 3F8YA 1RH3A 3FYVX 3NZDA 2FZHA 2W3VA 1RX7A 4KBNA 4P3QA 4EILA 3CLBA 4ELEA 4G8ZX 4Q0DA 3IRNA 2C2SA 4PTHA 4M6JA 1U71A 4KL9A 1PDBA 5HF2X 3NRRA 1RD7A 4HA7A 1DLSA 2HXVA 4KFJA 4KJJA 3QLWA 4OSGA 2W3MA 4QLFA 3FREX 3GI2A 2DRCA 3EIGA 3OAFA 4IXFX 1VDRA 3D80A 3INVA 1OHKA 3F91A 1S3UA 1RA8A 3FYWX 4G95A 4P3RA 4KLXA 1E26A 1ZDRA 3F0VX 4KM0A 3RG9A 3QLRA 3ZPCA 3LG4A 3UM8A 2FZJA 4KYAA 3I3RA 4PTJA 3QLYA 4XT6A 1HFRA 4DPDA 4PDJA 1MVSA 1JOLA 3FL8A 1RA2A 3QLZA 3TD8A 2H2QA 5HSUA 1RA1A 2ITHA 3FL9A 3VCOA 4EIGA 1JOMA 4IXGX 8DFRA 1LUDA 1AOEA 1DG8A 3L3RA 4KD7A 1AO8A 1DR3A 4LAHX 4I13A 5FDAA 1U70A 1KMVA 1J3IA 3IA5A 3DG8A 3TQ8A 4M2XA 1RG7A 1RB2A 4XT5A 1RE7A 3EEKA 1DISA 1DYJA 1U72A 4H97A 3JTWA 4H96A 3TQBA 4FGHA 3KFYA 3NXOA 4KY4A 3JWKA 3UM5A 2AZNA 4HOFA 3OCHA 3NXVA 1DREA 3DAUA 5JG0X 2O7PA 5U26A 3JW5A 1QZFA 3K74A 1J3JA 1DDSA 4NX7A 3SQYX 3SRRX 3CL9A 2BLCA 3FQCA 4DFRA 4ELGA 3F0QX 3FS6A 3FRFX 1RX2A 3IROA 2XW7A 2OBCA 4H95A 3CSEA 3S7AA 2L28A 3FQFA 3E0BA 1D1GA 1DRAA 4CD2A 4KEBA 4X5GA 3DL5A 4DPHA 1DHJA 1DR2A 3NXTA 1BZFA 4M6LA 3SRQX 4M7VA 3EX8A 4QI9A 1RX9A 3NZ6X 4KM2A 3HJ3A 3FY8X 1OHJA 3SRWX 2D0KA 1DG5A 3FRDX 4KJKA 4ELFA 2G6VA 4X5HA 5ECCA 4HOEA 3SH2A 1YHOA 1M7AA 3NZBX 3DFRA 3SRUX 3S3VA 1LY3A 1CZ3A 2W9SA 4XT4A 1KLKA 3ROAA 3HBBA 3CD2A 3SA2A 3D84X 6DFRA 3DRCA 1DYHA 3FY9X 4QHVA 3NZ9X 2DHFA 4X5IA 3GYFA 1DR6A 4ECKA 1TDRA 3GHWA 4LEKX 3EELA 2BL9A 4DP3A 1AI9A 2B3ZA 4M7UA 3SRSX 1DR7A 2ANQA 5HT5A 4Q67A 1J3KA 1VJ3A 5HPBA 1IA3A 4G3MA 2HQPA 3JWFA 4RGCA 4GH8A 3F8ZA 5ECXA 2HM9A 4KNEA 4PSSA 4DDRA 1DHFA 3F0UX 4IXED 4TU5X 1RC4A 1RF7A 3SAIA 4Q6AA 5CCCA 5HVBA 1S3WA 4XRBA 3TQAA 1RB3A 2W3WA 3ZPGA 1IA1A 1SEJA 3M08A 2JYBA 1DR5A 3RO9A 3TQ9A 3IA4A 5HVEA 4OR7A 3S9UA 2W9GA 5HQYA 1DRBA 4ELBA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3M09 A;  4P66 A;  3FQ0 A;  4XT8 A;  2W9T A;  4HOG A;  5HQZ A;  3N0H A;  4ELH A;  4NX6 A;  1PD9 A;  3FRB X;  1M79 A;  2BLB A;  1IA4 A;  3NXY A;  3QG2 A;  1DF7 A;  4P68 A;  5HT4 A;  1DR4 A;  3GHV A;  2ANO A;  3NXX A;  1DAJ A;  5JA3 A;  4LAG X;  3F0B X;  3NU0 A;  5HI6 A;  3JWC A;  4XE6 X;  2GD9 A;  3NZA X;  3EEJ A;  3JVX A;  4FHB A;  1RX8 A;  3SR5 X;  1RX4 A;  3FQZ A;  1HFP A;  3QYO A;  3GHC A;  2D5N A;  3Q1H A;  1M78 A;  2ZZA A;  3UM6 A;  4KY8 A;  5HF0 X;  3FQO A;  1LY4 A;  3KJR A;  3KJS A;  1RX3 A;  4M6K A;  1DHI A;  4X5F A;  1S3Y A;  3QFX A;  4XT7 A;  1DRF A;  1MVT A;  4KJL A;  3QLS A;  4H98 A;  4QJZ D;  4EJ1 A;  3IX9 A;  5HUI A;  5DXV A;  1DG7 A;  7DFR A;  2C2T A;  1S3V A;  3SGY A;  3QL3 A;  2LF1 A;  3K45 A;  1RX6 A;  3NTZ A;  2KGK A;  2CIG A;  1HFQ A;  3FQV A;  4XEC X;  4PSY A;  3QYL A;  2W9H A;  5DFR A;  4HA9 A;  4KAK A;  3QLX A;  2W3A A;  3F0S X;  3IRM A;  2INQ A;  1RX1 A;  3DGA A;  3DAT A;  1RA3 A;  2CD2 A;  1DRH A;  3EEM A;  3FRA X;  5CC9 A;  5EAJ A;  3DL6 A;  1DIU A;  4QLG A;  3I8A X;  1DR1 A;  1CD2 A;  1PD8 A;  3SA1 A;  1KMS A;  3QGT A;  2FZI A;  4I1N A;  1IA2 A;  4QLE A;  3F0X X;  1DLR A;  2OIP A;  3JSU A;  3JW3 A;  4PST A;  1RX5 A;  3QL0 A;  4FGG A;  2QK8 A;  4QJC A;  4X5J A;  2BLA A;  3R33 A;  3KGY A;  5HSR A;  1BOZ A;  3NXR A;  5U27 A;  4LAE X;  1RA9 A;  1DYR A;  1JUV A;  3JWM A;  1DDR A;  3K2H A;  2P4G A;  3K47 A;  3KY8 A;  1DYI A;  4EIZ A;  2W3B A;  5E8Q A;  3NZC X;  4Q0E A;  3F8Y A;  1RH3 A;  3FYV X;  3NZD A;  2FZH A;  2W3V A;  1RX7 A;  4KBN A;  4P3Q A;  4EIL A;  3CLB A;  4ELE A;  4G8Z X;  4Q0D A;  3IRN A;  2C2S A;  4PTH A;  4M6J A;  1U71 A;  4KL9 A;  1PDB A;  5HF2 X;  3NRR A;  1RD7 A;  4HA7 A;  1DLS A;  2HXV A;  4KFJ A;  4KJJ A;  3QLW A;  4OSG A;  2W3M A;  4QLF A;  3FRE X;  3GI2 A;  2DRC A;  3EIG A;  3OAF A;  4IXF X;  1VDR A;  3D80 A;  3INV A;  1OHK A;  3F91 A;  1S3U A;  1RA8 A;  3FYW X;  4G95 A;  4P3R A;  4KLX A;  1E26 A;  1ZDR A;  3F0V X;  4KM0 A;  3RG9 A;  3QLR A;  3ZPC A;  3LG4 A;  3UM8 A;  2FZJ A;  4KYA A;  3I3R A;  4PTJ A;  3QLY A;  4XT6 A;  1HFR A;  4DPD A;  4PDJ A;  1MVS A;  1JOL A;  3FL8 A;  1RA2 A;  3QLZ A;  3TD8 A;  2H2Q A;  5HSU A;  1RA1 A;  2ITH A;  3FL9 A;  3VCO A;  4EIG A;  1JOM A;  4IXG X;  8DFR A;  1LUD A;  1AOE A;  1DG8 A;  3L3R A;  4KD7 A;  1AO8 A;  1DR3 A;  4LAH X;  4I13 A;  5FDA A;  1U70 A;  1KMV A;  1J3I A;  3IA5 A;  3DG8 A;  3TQ8 A;  4M2X A;  1RG7 A;  1RB2 A;  4XT5 A;  1RE7 A;  3EEK A;  1DIS A;  1DYJ A;  1U72 A;  4H97 A;  3JTW A;  4H96 A;  3TQB A;  4FGH A;  3KFY A;  3NXO A;  4KY4 A;  3JWK A;  3UM5 A;  2AZN A;  4HOF A;  3OCH A;  3NXV A;  1DRE A;  3DAU A;  5JG0 X;  2O7P A;  5U26 A;  3JW5 A;  1QZF A;  3K74 A;  1J3J A;  1DDS A;  4NX7 A;  3SQY X;  3SRR X;  3CL9 A;  2BLC A;  3FQC A;  4DFR A;  4ELG A;  3F0Q X;  3FS6 A;  3FRF X;  1RX2 A;  3IRO A;  2XW7 A;  2OBC A;  4H95 A;  3CSE A;  3S7A A;  2L28 A;  3FQF A;  3E0B A;  1D1G A;  1DRA A;  4CD2 A;  4KEB A;  4X5G A;  3DL5 A;  4DPH A;  1DHJ A;  1DR2 A;  3NXT A;  1BZF A;  4M6L A;  3SRQ X;  4M7V A;  3EX8 A;  4QI9 A;  1RX9 A;  3NZ6 X;  4KM2 A;  3HJ3 A;  3FY8 X;  1OHJ A;  3SRW X;  2D0K A;  1DG5 A;  3FRD X;  4KJK A;  4ELF A;  2G6V A;  4X5H A;  5ECC A;  4HOE A;  3SH2 A;  1YHO A;  1M7A A;  3NZB X;  3DFR A;  3SRU X;  3S3V A;  1LY3 A;  1CZ3 A;  2W9S A;  4XT4 A;  1KLK A;  3ROA A;  3HBB A;  3CD2 A;  3SA2 A;  3D84 X;  6DFR A;  3DRC A;  1DYH A;  3FY9 X;  4QHV A;  3NZ9 X;  2DHF A;  4X5I A;  3GYF A;  1DR6 A;  4ECK A;  1TDR A;  3GHW A;  4LEK X;  3EEL A;  2BL9 A;  4DP3 A;  1AI9 A;  2B3Z A;  4M7U A;  3SRS X;  1DR7 A;  2ANQ A;  5HT5 A;  4Q67 A;  1J3K A;  1VJ3 A;  5HPB A;  1IA3 A;  4G3M A;  2HQP A;  3JWF A;  4RGC A;  4GH8 A;  3F8Z A;  5ECX A;  2HM9 A;  4KNE A;  4PSS A;  4DDR A;  1DHF A;  3F0U X;  4IXE D;  4TU5 X;  1RC4 A;  1RF7 A;  3SAI A;  4Q6A A;  5CCC A;  5HVB A;  1S3W A;  4XRB A;  3TQA A;  1RB3 A;  2W3W A;  3ZPG A;  1IA1 A;  1SEJ A;  3M08 A;  2JYB A;  1DR5 A;  3RO9 A;  3TQ9 A;  3IA4 A;  5HVE A;  4OR7 A;  3S9U A;  2W9G A;  5HQY A;  1DRB A;  4ELB A; 
#chains in the Genus database with same CATH topology
 3M09 A;  4P66 A;  3FQ0 A;  4XT8 A;  2W9T A;  4HOG A;  5HQZ A;  3N0H A;  4ELH A;  4NX6 A;  1PD9 A;  3FRB X;  1M79 A;  2BLB A;  1IA4 A;  3NXY A;  3QG2 A;  1DF7 A;  4P68 A;  5HT4 A;  1DR4 A;  3GHV A;  2ANO A;  3NXX A;  1DAJ A;  5JA3 A;  4LAG X;  3F0B X;  3NU0 A;  5HI6 A;  3JWC A;  4XE6 X;  2GD9 A;  3NZA X;  3EEJ A;  3JVX A;  4FHB A;  1RX8 A;  3SR5 X;  1RX4 A;  3FQZ A;  1HFP A;  3QYO A;  3GHC A;  2D5N A;  3Q1H A;  1M78 A;  2ZZA A;  3UM6 A;  4KY8 A;  5HF0 X;  3FQO A;  1LY4 A;  3KJR A;  3KJS A;  1RX3 A;  4M6K A;  1DHI A;  4X5F A;  1S3Y A;  3QFX A;  4XT7 A;  1DRF A;  1MVT A;  4KJL A;  3QLS A;  4H98 A;  4QJZ D;  4EJ1 A;  3IX9 A;  5HUI A;  5DXV A;  1DG7 A;  7DFR A;  2C2T A;  1S3V A;  3SGY A;  3QL3 A;  2LF1 A;  3K45 A;  1RX6 A;  3NTZ A;  2KGK A;  2CIG A;  1HFQ A;  3FQV A;  4XEC X;  4PSY A;  3QYL A;  2W9H A;  5DFR A;  4HA9 A;  4KAK A;  3QLX A;  2W3A A;  3F0S X;  3IRM A;  2INQ A;  1RX1 A;  3DGA A;  3DAT A;  1RA3 A;  2CD2 A;  1DRH A;  3EEM A;  3FRA X;  5CC9 A;  5EAJ A;  3DL6 A;  1DIU A;  4QLG A;  3I8A X;  1DR1 A;  1CD2 A;  1PD8 A;  3SA1 A;  1KMS A;  3QGT A;  2FZI A;  4I1N A;  1IA2 A;  4QLE A;  3F0X X;  1DLR A;  2OIP A;  3JSU A;  3JW3 A;  4PST A;  1RX5 A;  3QL0 A;  4FGG A;  2QK8 A;  4QJC A;  4X5J A;  2BLA A;  3R33 A;  3KGY A;  5HSR A;  1BOZ A;  3NXR A;  5U27 A;  4LAE X;  1RA9 A;  1DYR A;  1JUV A;  3JWM A;  1DDR A;  3K2H A;  2P4G A;  3K47 A;  3KY8 A;  1DYI A;  4EIZ A;  2W3B A;  5E8Q A;  3NZC X;  4Q0E A;  3F8Y A;  1RH3 A;  3FYV X;  3NZD A;  2FZH A;  2W3V A;  1RX7 A;  4KBN A;  4P3Q A;  4EIL A;  3CLB A;  4ELE A;  4G8Z X;  4Q0D A;  3IRN A;  2C2S A;  4PTH A;  4M6J A;  1U71 A;  4KL9 A;  1PDB A;  5HF2 X;  3NRR A;  1RD7 A;  4HA7 A;  1DLS A;  2HXV A;  4KFJ A;  4KJJ A;  3QLW A;  4OSG A;  2W3M A;  4QLF A;  3FRE X;  3GI2 A;  2DRC A;  3EIG A;  3OAF A;  4IXF X;  1VDR A;  3D80 A;  3INV A;  1OHK A;  3F91 A;  1S3U A;  1RA8 A;  3FYW X;  4G95 A;  4P3R A;  4KLX A;  1E26 A;  1ZDR A;  3F0V X;  4KM0 A;  3RG9 A;  3QLR A;  3ZPC A;  3LG4 A;  3UM8 A;  2FZJ A;  4KYA A;  3I3R A;  4PTJ A;  3QLY A;  4XT6 A;  1HFR A;  4DPD A;  4PDJ A;  1MVS A;  1JOL A;  3FL8 A;  1RA2 A;  3QLZ A;  3TD8 A;  2H2Q A;  5HSU A;  1RA1 A;  2ITH A;  3FL9 A;  3VCO A;  4EIG A;  1JOM A;  4IXG X;  8DFR A;  1LUD A;  1AOE A;  1DG8 A;  3L3R A;  4KD7 A;  1AO8 A;  1DR3 A;  4LAH X;  4I13 A;  5FDA A;  1U70 A;  1KMV A;  1J3I A;  3IA5 A;  3DG8 A;  3TQ8 A;  4M2X A;  1RG7 A;  1RB2 A;  4XT5 A;  1RE7 A;  3EEK A;  1DIS A;  1DYJ A;  1U72 A;  4H97 A;  3JTW A;  4H96 A;  3TQB A;  4FGH A;  3KFY A;  3NXO A;  4KY4 A;  3JWK A;  3UM5 A;  2AZN A;  4HOF A;  3OCH A;  3NXV A;  1DRE A;  3DAU A;  5JG0 X;  2O7P A;  5U26 A;  3JW5 A;  1QZF A;  3K74 A;  1J3J A;  1DDS A;  4NX7 A;  3SQY X;  3SRR X;  3CL9 A;  2BLC A;  3FQC A;  4DFR A;  4ELG A;  3F0Q X;  3FS6 A;  3FRF X;  1RX2 A;  3IRO A;  2XW7 A;  2OBC A;  4H95 A;  3CSE A;  3S7A A;  2L28 A;  3FQF A;  3E0B A;  1D1G A;  1DRA A;  4CD2 A;  4KEB A;  4X5G A;  3DL5 A;  4DPH A;  1DHJ A;  1DR2 A;  3NXT A;  1BZF A;  4M6L A;  3SRQ X;  4M7V A;  3EX8 A;  4QI9 A;  1RX9 A;  3NZ6 X;  4KM2 A;  3HJ3 A;  3FY8 X;  1OHJ A;  3SRW X;  2D0K A;  1DG5 A;  3FRD X;  4KJK A;  4ELF A;  2G6V A;  4X5H A;  5ECC A;  4HOE A;  3SH2 A;  1YHO A;  1M7A A;  3NZB X;  3DFR A;  3SRU X;  3S3V A;  1LY3 A;  1CZ3 A;  2W9S A;  4XT4 A;  1KLK A;  3ROA A;  3HBB A;  3CD2 A;  3SA2 A;  3D84 X;  6DFR A;  3DRC A;  1DYH A;  3FY9 X;  4QHV A;  3NZ9 X;  2DHF A;  4X5I A;  3GYF A;  1DR6 A;  4ECK A;  1TDR A;  3GHW A;  4LEK X;  3EEL A;  2BL9 A;  4DP3 A;  1AI9 A;  2B3Z A;  4M7U A;  3SRS X;  1DR7 A;  2ANQ A;  5HT5 A;  4Q67 A;  1J3K A;  1VJ3 A;  5HPB A;  1IA3 A;  4G3M A;  2HQP A;  3JWF A;  4RGC A;  4GH8 A;  3F8Z A;  5ECX A;  2HM9 A;  4KNE A;  4PSS A;  4DDR A;  1DHF A;  3F0U X;  4IXE D;  4TU5 X;  1RC4 A;  1RF7 A;  3SAI A;  4Q6A A;  5CCC A;  5HVB A;  1S3W A;  4XRB A;  3TQA A;  1RB3 A;  2W3W A;  3ZPG A;  1IA1 A;  1SEJ A;  3M08 A;  2JYB A;  1DR5 A;  3RO9 A;  3TQ9 A;  3IA4 A;  5HVE A;  4OR7 A;  3S9U A;  2W9G A;  5HQY A;  1DRB A;  4ELB A; 
#chains in the Genus database with same CATH homology
 3M09 A;  4P66 A;  3FQ0 A;  4XT8 A;  2W9T A;  4HOG A;  5HQZ A;  3N0H A;  4ELH A;  4NX6 A;  1PD9 A;  3FRB X;  1M79 A;  2BLB A;  1IA4 A;  3NXY A;  3QG2 A;  1DF7 A;  4P68 A;  5HT4 A;  1DR4 A;  3GHV A;  2ANO A;  3NXX A;  1DAJ A;  5JA3 A;  4LAG X;  3F0B X;  3NU0 A;  5HI6 A;  3JWC A;  4XE6 X;  2GD9 A;  3NZA X;  3EEJ A;  3JVX A;  4FHB A;  1RX8 A;  3SR5 X;  1RX4 A;  3FQZ A;  1HFP A;  3QYO A;  3GHC A;  2D5N A;  3Q1H A;  1M78 A;  2ZZA A;  3UM6 A;  4KY8 A;  5HF0 X;  3FQO A;  1LY4 A;  3KJR A;  3KJS A;  1RX3 A;  4M6K A;  1DHI A;  4X5F A;  1S3Y A;  3QFX A;  4XT7 A;  1DRF A;  1MVT A;  4KJL A;  3QLS A;  4H98 A;  4QJZ D;  4EJ1 A;  3IX9 A;  5HUI A;  5DXV A;  1DG7 A;  7DFR A;  2C2T A;  1S3V A;  3SGY A;  3QL3 A;  2LF1 A;  3K45 A;  1RX6 A;  3NTZ A;  2KGK A;  2CIG A;  1HFQ A;  3FQV A;  4XEC X;  4PSY A;  3QYL A;  2W9H A;  5DFR A;  4HA9 A;  4KAK A;  3QLX A;  2W3A A;  3F0S X;  3IRM A;  2INQ A;  1RX1 A;  3DGA A;  3DAT A;  1RA3 A;  2CD2 A;  1DRH A;  3EEM A;  3FRA X;  5CC9 A;  5EAJ A;  3DL6 A;  1DIU A;  4QLG A;  3I8A X;  1DR1 A;  1CD2 A;  1PD8 A;  3SA1 A;  1KMS A;  3QGT A;  2FZI A;  4I1N A;  1IA2 A;  4QLE A;  3F0X X;  1DLR A;  2OIP A;  3JSU A;  3JW3 A;  4PST A;  1RX5 A;  3QL0 A;  4FGG A;  2QK8 A;  4QJC A;  4X5J A;  2BLA A;  3R33 A;  3KGY A;  5HSR A;  1BOZ A;  3NXR A;  5U27 A;  4LAE X;  1RA9 A;  1DYR A;  1JUV A;  3JWM A;  1DDR A;  3K2H A;  2P4G A;  3K47 A;  3KY8 A;  1DYI A;  4EIZ A;  2W3B A;  5E8Q A;  3NZC X;  4Q0E A;  3F8Y A;  1RH3 A;  3FYV X;  3NZD A;  2FZH A;  2W3V A;  1RX7 A;  4KBN A;  4P3Q A;  4EIL A;  3CLB A;  4ELE A;  4G8Z X;  4Q0D A;  3IRN A;  2C2S A;  4PTH A;  4M6J A;  1U71 A;  4KL9 A;  1PDB A;  5HF2 X;  3NRR A;  1RD7 A;  4HA7 A;  1DLS A;  2HXV A;  4KFJ A;  4KJJ A;  3QLW A;  4OSG A;  2W3M A;  4QLF A;  3FRE X;  3GI2 A;  2DRC A;  3EIG A;  3OAF A;  4IXF X;  1VDR A;  3D80 A;  3INV A;  1OHK A;  3F91 A;  1S3U A;  1RA8 A;  3FYW X;  4G95 A;  4P3R A;  4KLX A;  1E26 A;  1ZDR A;  3F0V X;  4KM0 A;  3RG9 A;  3QLR A;  3ZPC A;  3LG4 A;  3UM8 A;  2FZJ A;  4KYA A;  3I3R A;  4PTJ A;  3QLY A;  4XT6 A;  1HFR A;  4DPD A;  4PDJ A;  1MVS A;  1JOL A;  3FL8 A;  1RA2 A;  3QLZ A;  3TD8 A;  2H2Q A;  5HSU A;  1RA1 A;  2ITH A;  3FL9 A;  3VCO A;  4EIG A;  1JOM A;  4IXG X;  8DFR A;  1LUD A;  1AOE A;  1DG8 A;  3L3R A;  4KD7 A;  1AO8 A;  1DR3 A;  4LAH X;  4I13 A;  5FDA A;  1U70 A;  1KMV A;  1J3I A;  3IA5 A;  3DG8 A;  3TQ8 A;  4M2X A;  1RG7 A;  1RB2 A;  4XT5 A;  1RE7 A;  3EEK A;  1DIS A;  1DYJ A;  1U72 A;  4H97 A;  3JTW A;  4H96 A;  3TQB A;  4FGH A;  3KFY A;  3NXO A;  4KY4 A;  3JWK A;  3UM5 A;  2AZN A;  4HOF A;  3OCH A;  3NXV A;  1DRE A;  3DAU A;  5JG0 X;  2O7P A;  5U26 A;  3JW5 A;  1QZF A;  3K74 A;  1J3J A;  1DDS A;  4NX7 A;  3SQY X;  3SRR X;  3CL9 A;  2BLC A;  3FQC A;  4DFR A;  4ELG A;  3F0Q X;  3FS6 A;  3FRF X;  1RX2 A;  3IRO A;  2XW7 A;  2OBC A;  4H95 A;  3CSE A;  3S7A A;  2L28 A;  3FQF A;  3E0B A;  1D1G A;  1DRA A;  4CD2 A;  4KEB A;  4X5G A;  3DL5 A;  4DPH A;  1DHJ A;  1DR2 A;  3NXT A;  1BZF A;  4M6L A;  3SRQ X;  4M7V A;  3EX8 A;  4QI9 A;  1RX9 A;  3NZ6 X;  4KM2 A;  3HJ3 A;  3FY8 X;  1OHJ A;  3SRW X;  2D0K A;  1DG5 A;  3FRD X;  4KJK A;  4ELF A;  2G6V A;  4X5H A;  5ECC A;  4HOE A;  3SH2 A;  1YHO A;  1M7A A;  3NZB X;  3DFR A;  3SRU X;  3S3V A;  1LY3 A;  1CZ3 A;  2W9S A;  4XT4 A;  1KLK A;  3ROA A;  3HBB A;  3CD2 A;  3SA2 A;  3D84 X;  6DFR A;  3DRC A;  1DYH A;  3FY9 X;  4QHV A;  3NZ9 X;  2DHF A;  4X5I A;  3GYF A;  1DR6 A;  4ECK A;  1TDR A;  3GHW A;  4LEK X;  3EEL A;  2BL9 A;  4DP3 A;  1AI9 A;  2B3Z A;  4M7U A;  3SRS X;  1DR7 A;  2ANQ A;  5HT5 A;  4Q67 A;  1J3K A;  1VJ3 A;  5HPB A;  1IA3 A;  4G3M A;  2HQP A;  3JWF A;  4RGC A;  4GH8 A;  3F8Z A;  5ECX A;  2HM9 A;  4KNE A;  4PSS A;  4DDR A;  1DHF A;  3F0U X;  4IXE D;  4TU5 X;  1RC4 A;  1RF7 A;  3SAI A;  4Q6A A;  5CCC A;  5HVB A;  1S3W A;  4XRB A;  3TQA A;  1RB3 A;  2W3W A;  3ZPG A;  1IA1 A;  1SEJ A;  3M08 A;  2JYB A;  1DR5 A;  3RO9 A;  3TQ9 A;  3IA4 A;  5HVE A;  4OR7 A;  3S9U A;  2W9G A;  5HQY A;  1DRB A;  4ELB A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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