1RG7A

Dihydrofolate reductase complexed with methotrexate
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 45
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1996-11-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1rg7A00
3VCOA 4QLEA 4H98A 3F0XX 1S3WA 3NTZA 1DLSA 1DAJA 5HSRA 4KL9A 1DRAA 4RGCA 1S3VA 1RX2A 2OBCA 2LF1A 3FQ0A 5HQZA 5HUIA 3F0VX 4ELEA 3F8YA 4QJZD 3QLZA 4HOGA 3QL3A 4PSSA 4EIGA 3IX9A 3FYWX 4FGHA 3FY8X 1RX8A 3NZ9X 4TU5X 4XT6A 4KYAA 4X5HA 1VDRA 1BZFA 3FS6A 4KBNA 1LUDA 3TQ9A 4H95A 4DDRA 1ZDRA 4EJ1A 2ANQA 1DR1A 4LAEX 1QZFA 3JWFA 2ZZAA 1KMSA 4NX6A 3K47A 3K45A 3JW3A 3FQVA 3FRBX 3UM6A 3NXXA 3DFRA 1S3YA 1HFQA 1RX9A 1VJ3A 1RA8A 4CD2A 4X5JA 3FRDX 3N0HA 1JOLA 3QYLA 3NZCX 2BL9A 3K2HA 5HVEA 4M2XA 1IA3A 3TQ8A 3GYFA 2W3MA 2D0KA 3ZPCA 3EX8A 4KLXA 2XW7A 3KFYA 1DR7A 2W9HA 4EILA 3QFXA 4ECKA 3I8AX 5U26A 2KGKA 1RC4A 3TQAA 1DDSA 5HT5A 4IXFX 3FQCA 3EEJA 1DISA 4OR7A 3NXTA 1LY3A 3EEMA 4KAKA 2W9SA 4XE6X 3SH2A 1RX6A 3NRRA 3QLYA 4Q0EA 4EIZA 4DFRA 1AI9A 3INVA 5HI6A 3QLRA 3KJRA 3S9UA 1RA3A 3QYOA 3M08A 4DPHA 4M6KA 3JWCA 2BLCA 4FHBA 3NXYA 3EEKA 5CCCA 4XECX 2ANOA 3QLWA 1DIUA 3RG9A 3SAIA 4DP3A 4KJJA 5JA3A 3IRMA 4OSGA 4H96A 3IRNA 3FY9X 1KLKA 4G3MA 3GHCA 3F8ZA 3JW5A 2HM9A 3DL5A 3TD8A 3HJ3A 3GHWA 3JVXA 2FZIA 1DYIA 3SRQX 1DREA 3DL6A 3K74A 3IA4A 1JOMA 5HQYA 3GI2A 4PTHA 8DFRA 5E8QA 1RD7A 2W3BA 3SA2A 4ELGA 3S7AA 1CD2A 1TDRA 1DG8A 3JWKA 5CC9A 3NXVA 4KFJA 3FL8A 2OIPA 1RA9A 4P68A 3DRCA 1DG7A 4P3RA 1HFRA 1S3UA 4I1NA 5HPBA 4ELFA 1DHFA 3FQOA 1RX1A 4GH8A 1RA1A 4PSYA 1J3KA 3F0QX 1DDRA 3NXRA 2HQPA 1RG7A 4PDJA 5HVBA 2FZHA 1PD8A 3E0BA 3F91A 4QHVA 2DHFA 2C2SA 1DR5A 3TQBA 4M6LA 3OAFA 3NZDA 4QLFA 2GD9A 1DR3A 1U70A 4KM2A 1M7AA 1OHKA 4QI9A 3F0BX 3UM5A 1DR2A 3EELA 3SGYA 3D80A 1RX7A 1MVSA 3SRUX 5ECXA 3QG2A 3JTWA 1IA4A 1RB2A 2W9TA 3M09A 4I13A 4Q67A 1DRFA 2CD2A 3FREX 4X5IA 4PTJA 3SR5X 3FQZA 3SRSX 7DFRA 3DAUA 1J3JA 2W3WA 1D1GA 4KJKA 5JG0X 3F0SX 4HA7A 2HXVA 3KJSA 4KJLA 1RX5A 2B3ZA 1J3IA 1U71A 3SA1A 2BLAA 3NZ6X 4QLGA 1DYHA 1PDBA 3FRFX 4IXGX 1DYRA 1U72A 1JUVA 1E26A 1AO8A 4LAGX 5HF2X 2W9GA 4G95A 3EIGA 1RX4A 1OHJA 1M78A 2O7PA 4IXED 1KMVA 3CD2A 3Q1HA 4M7UA 3CLBA 3NZAX 3CSEA 3L3RA 1DR4A 2L28A 1DRBA 3CL9A 5HF0X 2INQA 3QL0A 3KY8A 3NZBX 3I3RA 1DR6A 4KY8A 2W3VA 3KGYA 4XT7A 4KY4A 6DFRA 1LY4A 3SRWX 3GHVA 2DRCA 4LEKX 1RX3A 3JWMA 2C2TA 4KM0A 2JYBA 4M6JA 1DHJA 2BLBA 3LG4A 4NX7A 1M79A 3HBBA 3ZPGA 1CZ3A 2ITHA 4HA9A 5EAJA 5DXVA 1RF7A 3DGAA 5U27A 1AOEA 4ELBA 3D84X 4Q0DA 4HOEA 1DF7A 3F0UX 3OCHA 1DLRA 3FQFA 3FL9A 4LAHX 1RH3A 1PD9A 4X5FA 1DG5A 1DRHA 5DFRA 4P66A 2P4GA 4H97A 1HFPA 4PSTA 4M7VA 1RE7A 1YHOA 4HOFA 3S3VA 1MVTA 3FYVX 4KNEA 5FDAA 1DHIA 3UM8A 1IA2A 3ROAA 3NU0A 4KEBA 3QGTA 4ELHA 5ECCA 3RO9A 4KD7A 3QLSA 4Q6AA 1BOZA 3DG8A 1RB3A 3R33A 2G6VA 2FZJA 2QK8A 2H2QA 4XT8A 2W3AA 4G8ZX 3JSUA 4DPDA 4XT4A 1IA1A 1RA2A 4QJCA 3DATA 1SEJA 1DYJA 4FGGA 3IROA 3SRRX 4X5GA 5HT4A 4XRBA 3QLXA 4P3QA 3NXOA 3FRAX 2D5NA 3IA5A 2CIGA 2AZNA 5HSUA 4XT5A 3SQYX
chains in the Genus database with same CATH superfamily
3VCOA 4QLEA 4H98A 3F0XX 1S3WA 3NTZA 1DLSA 1DAJA 5HSRA 4KL9A 1DRAA 4RGCA 1S3VA 1RX2A 2OBCA 2LF1A 3FQ0A 5HQZA 5HUIA 3F0VX 4ELEA 3F8YA 4QJZD 3QLZA 4HOGA 3QL3A 4PSSA 4EIGA 3IX9A 3FYWX 4FGHA 3FY8X 1RX8A 3NZ9X 4TU5X 4XT6A 4KYAA 4X5HA 1VDRA 1BZFA 3FS6A 4KBNA 1LUDA 3TQ9A 4H95A 4DDRA 1ZDRA 4EJ1A 2ANQA 1DR1A 4LAEX 1QZFA 3JWFA 2ZZAA 1KMSA 4NX6A 3K47A 3K45A 3JW3A 3FQVA 3FRBX 3UM6A 3NXXA 3DFRA 1S3YA 1HFQA 1RX9A 1VJ3A 1RA8A 4CD2A 4X5JA 3FRDX 3N0HA 1JOLA 3QYLA 3NZCX 2BL9A 3K2HA 5HVEA 4M2XA 1IA3A 3TQ8A 3GYFA 2W3MA 2D0KA 3ZPCA 3EX8A 4KLXA 2XW7A 3KFYA 1DR7A 2W9HA 4EILA 3QFXA 4ECKA 3I8AX 5U26A 2KGKA 1RC4A 3TQAA 1DDSA 5HT5A 4IXFX 3FQCA 3EEJA 1DISA 4OR7A 3NXTA 1LY3A 3EEMA 4KAKA 2W9SA 4XE6X 3SH2A 1RX6A 3NRRA 3QLYA 4Q0EA 4EIZA 4DFRA 1AI9A 3INVA 5HI6A 3QLRA 3KJRA 3S9UA 1RA3A 3QYOA 3M08A 4DPHA 4M6KA 3JWCA 2BLCA 4FHBA 3NXYA 3EEKA 5CCCA 4XECX 2ANOA 3QLWA 1DIUA 3RG9A 3SAIA 4DP3A 4KJJA 5JA3A 3IRMA 4OSGA 4H96A 3IRNA 3FY9X 1KLKA 4G3MA 3GHCA 3F8ZA 3JW5A 2HM9A 3DL5A 3TD8A 3HJ3A 3GHWA 3JVXA 2FZIA 1DYIA 3SRQX 1DREA 3DL6A 3K74A 3IA4A 1JOMA 5HQYA 3GI2A 4PTHA 8DFRA 5E8QA 1RD7A 2W3BA 3SA2A 4ELGA 3S7AA 1CD2A 1TDRA 1DG8A 3JWKA 5CC9A 3NXVA 4KFJA 3FL8A 2OIPA 1RA9A 4P68A 3DRCA 1DG7A 4P3RA 1HFRA 1S3UA 4I1NA 5HPBA 4ELFA 1DHFA 3FQOA 1RX1A 4GH8A 1RA1A 4PSYA 1J3KA 3F0QX 1DDRA 3NXRA 2HQPA 1RG7A 4PDJA 5HVBA 2FZHA 1PD8A 3E0BA 3F91A 4QHVA 2DHFA 2C2SA 1DR5A 3TQBA 4M6LA 3OAFA 3NZDA 4QLFA 2GD9A 1DR3A 1U70A 4KM2A 1M7AA 1OHKA 4QI9A 3F0BX 3UM5A 1DR2A 3EELA 3SGYA 3D80A 1RX7A 1MVSA 3SRUX 5ECXA 3QG2A 3JTWA 1IA4A 1RB2A 2W9TA 3M09A 4I13A 4Q67A 1DRFA 2CD2A 3FREX 4X5IA 4PTJA 3SR5X 3FQZA 3SRSX 7DFRA 3DAUA 1J3JA 2W3WA 1D1GA 4KJKA 5JG0X 3F0SX 4HA7A 2HXVA 3KJSA 4KJLA 1RX5A 2B3ZA 1J3IA 1U71A 3SA1A 2BLAA 3NZ6X 4QLGA 1DYHA 1PDBA 3FRFX 4IXGX 1DYRA 1U72A 1JUVA 1E26A 1AO8A 4LAGX 5HF2X 2W9GA 4G95A 3EIGA 1RX4A 1OHJA 1M78A 2O7PA 4IXED 1KMVA 3CD2A 3Q1HA 4M7UA 3CLBA 3NZAX 3CSEA 3L3RA 1DR4A 2L28A 1DRBA 3CL9A 5HF0X 2INQA 3QL0A 3KY8A 3NZBX 3I3RA 1DR6A 4KY8A 2W3VA 3KGYA 4XT7A 4KY4A 6DFRA 1LY4A 3SRWX 3GHVA 2DRCA 4LEKX 1RX3A 3JWMA 2C2TA 4KM0A 2JYBA 4M6JA 1DHJA 2BLBA 3LG4A 4NX7A 1M79A 3HBBA 3ZPGA 1CZ3A 2ITHA 4HA9A 5EAJA 5DXVA 1RF7A 3DGAA 5U27A 1AOEA 4ELBA 3D84X 4Q0DA 4HOEA 1DF7A 3F0UX 3OCHA 1DLRA 3FQFA 3FL9A 4LAHX 1RH3A 1PD9A 4X5FA 1DG5A 1DRHA 5DFRA 4P66A 2P4GA 4H97A 1HFPA 4PSTA 4M7VA 1RE7A 1YHOA 4HOFA 3S3VA 1MVTA 3FYVX 4KNEA 5FDAA 1DHIA 3UM8A 1IA2A 3ROAA 3NU0A 4KEBA 3QGTA 4ELHA 5ECCA 3RO9A 4KD7A 3QLSA 4Q6AA 1BOZA 3DG8A 1RB3A 3R33A 2G6VA 2FZJA 2QK8A 2H2QA 4XT8A 2W3AA 4G8ZX 3JSUA 4DPDA 4XT4A 1IA1A 1RA2A 4QJCA 3DATA 1SEJA 1DYJA 4FGGA 3IROA 3SRRX 4X5GA 5HT4A 4XRBA 3QLXA 4P3QA 3NXOA 3FRAX 2D5NA 3IA5A 2CIGA 2AZNA 5HSUA 4XT5A 3SQYX
chains in the Genus database with same CATH topology
3VCOA 4QLEA 4H98A 3F0XX 1S3WA 3NTZA 1DLSA 1DAJA 5HSRA 4KL9A 1DRAA 4RGCA 1S3VA 1RX2A 2OBCA 2LF1A 3FQ0A 5HQZA 5HUIA 3F0VX 4ELEA 3F8YA 4QJZD 3QLZA 4HOGA 3QL3A 4PSSA 4EIGA 3IX9A 3FYWX 4FGHA 3FY8X 1RX8A 3NZ9X 4TU5X 4XT6A 4KYAA 4X5HA 1VDRA 1BZFA 3FS6A 4KBNA 1LUDA 3TQ9A 4H95A 4DDRA 1ZDRA 4EJ1A 2ANQA 1DR1A 4LAEX 1QZFA 3JWFA 2ZZAA 1KMSA 4NX6A 3K47A 3K45A 3JW3A 3FQVA 3FRBX 3UM6A 3NXXA 3DFRA 1S3YA 1HFQA 1RX9A 1VJ3A 1RA8A 4CD2A 4X5JA 3FRDX 3N0HA 1JOLA 3QYLA 3NZCX 2BL9A 3K2HA 5HVEA 4M2XA 1IA3A 3TQ8A 3GYFA 2W3MA 2D0KA 3ZPCA 3EX8A 4KLXA 2XW7A 3KFYA 1DR7A 2W9HA 4EILA 3QFXA 4ECKA 3I8AX 5U26A 2KGKA 1RC4A 3TQAA 1DDSA 5HT5A 4IXFX 3FQCA 3EEJA 1DISA 4OR7A 3NXTA 1LY3A 3EEMA 4KAKA 2W9SA 4XE6X 3SH2A 1RX6A 3NRRA 3QLYA 4Q0EA 4EIZA 4DFRA 1AI9A 3INVA 5HI6A 3QLRA 3KJRA 3S9UA 1RA3A 3QYOA 3M08A 4DPHA 4M6KA 3JWCA 2BLCA 4FHBA 3NXYA 3EEKA 5CCCA 4XECX 2ANOA 3QLWA 1DIUA 3RG9A 3SAIA 4DP3A 4KJJA 5JA3A 3IRMA 4OSGA 4H96A 3IRNA 3FY9X 1KLKA 4G3MA 3GHCA 3F8ZA 3JW5A 2HM9A 3DL5A 3TD8A 3HJ3A 3GHWA 3JVXA 2FZIA 1DYIA 3SRQX 1DREA 3DL6A 3K74A 3IA4A 1JOMA 5HQYA 3GI2A 4PTHA 8DFRA 5E8QA 1RD7A 2W3BA 3SA2A 4ELGA 3S7AA 1CD2A 1TDRA 1DG8A 3JWKA 5CC9A 3NXVA 4KFJA 3FL8A 2OIPA 1RA9A 4P68A 3DRCA 1DG7A 4P3RA 1HFRA 1S3UA 4I1NA 5HPBA 4ELFA 1DHFA 3FQOA 1RX1A 4GH8A 1RA1A 4PSYA 1J3KA 3F0QX 1DDRA 3NXRA 2HQPA 1RG7A 4PDJA 5HVBA 2FZHA 1PD8A 3E0BA 3F91A 4QHVA 2DHFA 2C2SA 1DR5A 3TQBA 4M6LA 3OAFA 3NZDA 4QLFA 2GD9A 1DR3A 1U70A 4KM2A 1M7AA 1OHKA 4QI9A 3F0BX 3UM5A 1DR2A 3EELA 3SGYA 3D80A 1RX7A 1MVSA 3SRUX 5ECXA 3QG2A 3JTWA 1IA4A 1RB2A 2W9TA 3M09A 4I13A 4Q67A 1DRFA 2CD2A 3FREX 4X5IA 4PTJA 3SR5X 3FQZA 3SRSX 7DFRA 3DAUA 1J3JA 2W3WA 1D1GA 4KJKA 5JG0X 3F0SX 4HA7A 2HXVA 3KJSA 4KJLA 1RX5A 2B3ZA 1J3IA 1U71A 3SA1A 2BLAA 3NZ6X 4QLGA 1DYHA 1PDBA 3FRFX 4IXGX 1DYRA 1U72A 1JUVA 1E26A 1AO8A 4LAGX 5HF2X 2W9GA 4G95A 3EIGA 1RX4A 1OHJA 1M78A 2O7PA 4IXED 1KMVA 3CD2A 3Q1HA 4M7UA 3CLBA 3NZAX 3CSEA 3L3RA 1DR4A 2L28A 1DRBA 3CL9A 5HF0X 2INQA 3QL0A 3KY8A 3NZBX 3I3RA 1DR6A 4KY8A 2W3VA 3KGYA 4XT7A 4KY4A 6DFRA 1LY4A 3SRWX 3GHVA 2DRCA 4LEKX 1RX3A 3JWMA 2C2TA 4KM0A 2JYBA 4M6JA 1DHJA 2BLBA 3LG4A 4NX7A 1M79A 3HBBA 3ZPGA 1CZ3A 2ITHA 4HA9A 5EAJA 5DXVA 1RF7A 3DGAA 5U27A 1AOEA 4ELBA 3D84X 4Q0DA 4HOEA 1DF7A 3F0UX 3OCHA 1DLRA 3FQFA 3FL9A 4LAHX 1RH3A 1PD9A 4X5FA 1DG5A 1DRHA 5DFRA 4P66A 2P4GA 4H97A 1HFPA 4PSTA 4M7VA 1RE7A 1YHOA 4HOFA 3S3VA 1MVTA 3FYVX 4KNEA 5FDAA 1DHIA 3UM8A 1IA2A 3ROAA 3NU0A 4KEBA 3QGTA 4ELHA 5ECCA 3RO9A 4KD7A 3QLSA 4Q6AA 1BOZA 3DG8A 1RB3A 3R33A 2G6VA 2FZJA 2QK8A 2H2QA 4XT8A 2W3AA 4G8ZX 3JSUA 4DPDA 4XT4A 1IA1A 1RA2A 4QJCA 3DATA 1SEJA 1DYJA 4FGGA 3IROA 3SRRX 4X5GA 5HT4A 4XRBA 3QLXA 4P3QA 3NXOA 3FRAX 2D5NA 3IA5A 2CIGA 2AZNA 5HSUA 4XT5A 3SQYX
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3VCO A;  4QLE A;  4H98 A;  3F0X X;  1S3W A;  3NTZ A;  1DLS A;  1DAJ A;  5HSR A;  4KL9 A;  1DRA A;  4RGC A;  1S3V A;  1RX2 A;  2OBC A;  2LF1 A;  3FQ0 A;  5HQZ A;  5HUI A;  3F0V X;  4ELE A;  3F8Y A;  4QJZ D;  3QLZ A;  4HOG A;  3QL3 A;  4PSS A;  4EIG A;  3IX9 A;  3FYW X;  4FGH A;  3FY8 X;  1RX8 A;  3NZ9 X;  4TU5 X;  4XT6 A;  4KYA A;  4X5H A;  1VDR A;  1BZF A;  3FS6 A;  4KBN A;  1LUD A;  3TQ9 A;  4H95 A;  4DDR A;  1ZDR A;  4EJ1 A;  2ANQ A;  1DR1 A;  4LAE X;  1QZF A;  3JWF A;  2ZZA A;  1KMS A;  4NX6 A;  3K47 A;  3K45 A;  3JW3 A;  3FQV A;  3FRB X;  3UM6 A;  3NXX A;  3DFR A;  1S3Y A;  1HFQ A;  1RX9 A;  1VJ3 A;  1RA8 A;  4CD2 A;  4X5J A;  3FRD X;  3N0H A;  1JOL A;  3QYL A;  3NZC X;  2BL9 A;  3K2H A;  5HVE A;  4M2X A;  1IA3 A;  3TQ8 A;  3GYF A;  2W3M A;  2D0K A;  3ZPC A;  3EX8 A;  4KLX A;  2XW7 A;  3KFY A;  1DR7 A;  2W9H A;  4EIL A;  3QFX A;  4ECK A;  3I8A X;  5U26 A;  2KGK A;  1RC4 A;  3TQA A;  1DDS A;  5HT5 A;  4IXF X;  3FQC A;  3EEJ A;  1DIS A;  4OR7 A;  3NXT A;  1LY3 A;  3EEM A;  4KAK A;  2W9S A;  4XE6 X;  3SH2 A;  1RX6 A;  3NRR A;  3QLY A;  4Q0E A;  4EIZ A;  4DFR A;  1AI9 A;  3INV A;  5HI6 A;  3QLR A;  3KJR A;  3S9U A;  1RA3 A;  3QYO A;  3M08 A;  4DPH A;  4M6K A;  3JWC A;  2BLC A;  4FHB A;  3NXY A;  3EEK A;  5CCC A;  4XEC X;  2ANO A;  3QLW A;  1DIU A;  3RG9 A;  3SAI A;  4DP3 A;  4KJJ A;  5JA3 A;  3IRM A;  4OSG A;  4H96 A;  3IRN A;  3FY9 X;  1KLK A;  4G3M A;  3GHC A;  3F8Z A;  3JW5 A;  2HM9 A;  3DL5 A;  3TD8 A;  3HJ3 A;  3GHW A;  3JVX A;  2FZI A;  1DYI A;  3SRQ X;  1DRE A;  3DL6 A;  3K74 A;  3IA4 A;  1JOM A;  5HQY A;  3GI2 A;  4PTH A;  8DFR A;  5E8Q A;  1RD7 A;  2W3B A;  3SA2 A;  4ELG A;  3S7A A;  1CD2 A;  1TDR A;  1DG8 A;  3JWK A;  5CC9 A;  3NXV A;  4KFJ A;  3FL8 A;  2OIP A;  1RA9 A;  4P68 A;  3DRC A;  1DG7 A;  4P3R A;  1HFR A;  1S3U A;  4I1N A;  5HPB A;  4ELF A;  1DHF A;  3FQO A;  1RX1 A;  4GH8 A;  1RA1 A;  4PSY A;  1J3K A;  3F0Q X;  1DDR A;  3NXR A;  2HQP A;  1RG7 A;  4PDJ A;  5HVB A;  2FZH A;  1PD8 A;  3E0B A;  3F91 A;  4QHV A;  2DHF A;  2C2S A;  1DR5 A;  3TQB A;  4M6L A;  3OAF A;  3NZD A;  4QLF A;  2GD9 A;  1DR3 A;  1U70 A;  4KM2 A;  1M7A A;  1OHK A;  4QI9 A;  3F0B X;  3UM5 A;  1DR2 A;  3EEL A;  3SGY A;  3D80 A;  1RX7 A;  1MVS A;  3SRU X;  5ECX A;  3QG2 A;  3JTW A;  1IA4 A;  1RB2 A;  2W9T A;  3M09 A;  4I13 A;  4Q67 A;  1DRF A;  2CD2 A;  3FRE X;  4X5I A;  4PTJ A;  3SR5 X;  3FQZ A;  3SRS X;  7DFR A;  3DAU A;  1J3J A;  2W3W A;  1D1G A;  4KJK A;  5JG0 X;  3F0S X;  4HA7 A;  2HXV A;  3KJS A;  4KJL A;  1RX5 A;  2B3Z A;  1J3I A;  1U71 A;  3SA1 A;  2BLA A;  3NZ6 X;  4QLG A;  1DYH A;  1PDB A;  3FRF X;  4IXG X;  1DYR A;  1U72 A;  1JUV A;  1E26 A;  1AO8 A;  4LAG X;  5HF2 X;  2W9G A;  4G95 A;  3EIG A;  1RX4 A;  1OHJ A;  1M78 A;  2O7P A;  4IXE D;  1KMV A;  3CD2 A;  3Q1H A;  4M7U A;  3CLB A;  3NZA X;  3CSE A;  3L3R A;  1DR4 A;  2L28 A;  1DRB A;  3CL9 A;  5HF0 X;  2INQ A;  3QL0 A;  3KY8 A;  3NZB X;  3I3R A;  1DR6 A;  4KY8 A;  2W3V A;  3KGY A;  4XT7 A;  4KY4 A;  6DFR A;  1LY4 A;  3SRW X;  3GHV A;  2DRC A;  4LEK X;  1RX3 A;  3JWM A;  2C2T A;  4KM0 A;  2JYB A;  4M6J A;  1DHJ A;  2BLB A;  3LG4 A;  4NX7 A;  1M79 A;  3HBB A;  3ZPG A;  1CZ3 A;  2ITH A;  4HA9 A;  5EAJ A;  5DXV A;  1RF7 A;  3DGA A;  5U27 A;  1AOE A;  4ELB A;  3D84 X;  4Q0D A;  4HOE A;  1DF7 A;  3F0U X;  3OCH A;  1DLR A;  3FQF A;  3FL9 A;  4LAH X;  1RH3 A;  1PD9 A;  4X5F A;  1DG5 A;  1DRH A;  5DFR A;  4P66 A;  2P4G A;  4H97 A;  1HFP A;  4PST A;  4M7V A;  1RE7 A;  1YHO A;  4HOF A;  3S3V A;  1MVT A;  3FYV X;  4KNE A;  5FDA A;  1DHI A;  3UM8 A;  1IA2 A;  3ROA A;  3NU0 A;  4KEB A;  3QGT A;  4ELH A;  5ECC A;  3RO9 A;  4KD7 A;  3QLS A;  4Q6A A;  1BOZ A;  3DG8 A;  1RB3 A;  3R33 A;  2G6V A;  2FZJ A;  2QK8 A;  2H2Q A;  4XT8 A;  2W3A A;  4G8Z X;  3JSU A;  4DPD A;  4XT4 A;  1IA1 A;  1RA2 A;  4QJC A;  3DAT A;  1SEJ A;  1DYJ A;  4FGG A;  3IRO A;  3SRR X;  4X5G A;  5HT4 A;  4XRB A;  3QLX A;  4P3Q A;  3NXO A;  3FRA X;  2D5N A;  3IA5 A;  2CIG A;  2AZN A;  5HSU A;  4XT5 A;  3SQY X; 
#chains in the Genus database with same CATH topology
 3VCO A;  4QLE A;  4H98 A;  3F0X X;  1S3W A;  3NTZ A;  1DLS A;  1DAJ A;  5HSR A;  4KL9 A;  1DRA A;  4RGC A;  1S3V A;  1RX2 A;  2OBC A;  2LF1 A;  3FQ0 A;  5HQZ A;  5HUI A;  3F0V X;  4ELE A;  3F8Y A;  4QJZ D;  3QLZ A;  4HOG A;  3QL3 A;  4PSS A;  4EIG A;  3IX9 A;  3FYW X;  4FGH A;  3FY8 X;  1RX8 A;  3NZ9 X;  4TU5 X;  4XT6 A;  4KYA A;  4X5H A;  1VDR A;  1BZF A;  3FS6 A;  4KBN A;  1LUD A;  3TQ9 A;  4H95 A;  4DDR A;  1ZDR A;  4EJ1 A;  2ANQ A;  1DR1 A;  4LAE X;  1QZF A;  3JWF A;  2ZZA A;  1KMS A;  4NX6 A;  3K47 A;  3K45 A;  3JW3 A;  3FQV A;  3FRB X;  3UM6 A;  3NXX A;  3DFR A;  1S3Y A;  1HFQ A;  1RX9 A;  1VJ3 A;  1RA8 A;  4CD2 A;  4X5J A;  3FRD X;  3N0H A;  1JOL A;  3QYL A;  3NZC X;  2BL9 A;  3K2H A;  5HVE A;  4M2X A;  1IA3 A;  3TQ8 A;  3GYF A;  2W3M A;  2D0K A;  3ZPC A;  3EX8 A;  4KLX A;  2XW7 A;  3KFY A;  1DR7 A;  2W9H A;  4EIL A;  3QFX A;  4ECK A;  3I8A X;  5U26 A;  2KGK A;  1RC4 A;  3TQA A;  1DDS A;  5HT5 A;  4IXF X;  3FQC A;  3EEJ A;  1DIS A;  4OR7 A;  3NXT A;  1LY3 A;  3EEM A;  4KAK A;  2W9S A;  4XE6 X;  3SH2 A;  1RX6 A;  3NRR A;  3QLY A;  4Q0E A;  4EIZ A;  4DFR A;  1AI9 A;  3INV A;  5HI6 A;  3QLR A;  3KJR A;  3S9U A;  1RA3 A;  3QYO A;  3M08 A;  4DPH A;  4M6K A;  3JWC A;  2BLC A;  4FHB A;  3NXY A;  3EEK A;  5CCC A;  4XEC X;  2ANO A;  3QLW A;  1DIU A;  3RG9 A;  3SAI A;  4DP3 A;  4KJJ A;  5JA3 A;  3IRM A;  4OSG A;  4H96 A;  3IRN A;  3FY9 X;  1KLK A;  4G3M A;  3GHC A;  3F8Z A;  3JW5 A;  2HM9 A;  3DL5 A;  3TD8 A;  3HJ3 A;  3GHW A;  3JVX A;  2FZI A;  1DYI A;  3SRQ X;  1DRE A;  3DL6 A;  3K74 A;  3IA4 A;  1JOM A;  5HQY A;  3GI2 A;  4PTH A;  8DFR A;  5E8Q A;  1RD7 A;  2W3B A;  3SA2 A;  4ELG A;  3S7A A;  1CD2 A;  1TDR A;  1DG8 A;  3JWK A;  5CC9 A;  3NXV A;  4KFJ A;  3FL8 A;  2OIP A;  1RA9 A;  4P68 A;  3DRC A;  1DG7 A;  4P3R A;  1HFR A;  1S3U A;  4I1N A;  5HPB A;  4ELF A;  1DHF A;  3FQO A;  1RX1 A;  4GH8 A;  1RA1 A;  4PSY A;  1J3K A;  3F0Q X;  1DDR A;  3NXR A;  2HQP A;  1RG7 A;  4PDJ A;  5HVB A;  2FZH A;  1PD8 A;  3E0B A;  3F91 A;  4QHV A;  2DHF A;  2C2S A;  1DR5 A;  3TQB A;  4M6L A;  3OAF A;  3NZD A;  4QLF A;  2GD9 A;  1DR3 A;  1U70 A;  4KM2 A;  1M7A A;  1OHK A;  4QI9 A;  3F0B X;  3UM5 A;  1DR2 A;  3EEL A;  3SGY A;  3D80 A;  1RX7 A;  1MVS A;  3SRU X;  5ECX A;  3QG2 A;  3JTW A;  1IA4 A;  1RB2 A;  2W9T A;  3M09 A;  4I13 A;  4Q67 A;  1DRF A;  2CD2 A;  3FRE X;  4X5I A;  4PTJ A;  3SR5 X;  3FQZ A;  3SRS X;  7DFR A;  3DAU A;  1J3J A;  2W3W A;  1D1G A;  4KJK A;  5JG0 X;  3F0S X;  4HA7 A;  2HXV A;  3KJS A;  4KJL A;  1RX5 A;  2B3Z A;  1J3I A;  1U71 A;  3SA1 A;  2BLA A;  3NZ6 X;  4QLG A;  1DYH A;  1PDB A;  3FRF X;  4IXG X;  1DYR A;  1U72 A;  1JUV A;  1E26 A;  1AO8 A;  4LAG X;  5HF2 X;  2W9G A;  4G95 A;  3EIG A;  1RX4 A;  1OHJ A;  1M78 A;  2O7P A;  4IXE D;  1KMV A;  3CD2 A;  3Q1H A;  4M7U A;  3CLB A;  3NZA X;  3CSE A;  3L3R A;  1DR4 A;  2L28 A;  1DRB A;  3CL9 A;  5HF0 X;  2INQ A;  3QL0 A;  3KY8 A;  3NZB X;  3I3R A;  1DR6 A;  4KY8 A;  2W3V A;  3KGY A;  4XT7 A;  4KY4 A;  6DFR A;  1LY4 A;  3SRW X;  3GHV A;  2DRC A;  4LEK X;  1RX3 A;  3JWM A;  2C2T A;  4KM0 A;  2JYB A;  4M6J A;  1DHJ A;  2BLB A;  3LG4 A;  4NX7 A;  1M79 A;  3HBB A;  3ZPG A;  1CZ3 A;  2ITH A;  4HA9 A;  5EAJ A;  5DXV A;  1RF7 A;  3DGA A;  5U27 A;  1AOE A;  4ELB A;  3D84 X;  4Q0D A;  4HOE A;  1DF7 A;  3F0U X;  3OCH A;  1DLR A;  3FQF A;  3FL9 A;  4LAH X;  1RH3 A;  1PD9 A;  4X5F A;  1DG5 A;  1DRH A;  5DFR A;  4P66 A;  2P4G A;  4H97 A;  1HFP A;  4PST A;  4M7V A;  1RE7 A;  1YHO A;  4HOF A;  3S3V A;  1MVT A;  3FYV X;  4KNE A;  5FDA A;  1DHI A;  3UM8 A;  1IA2 A;  3ROA A;  3NU0 A;  4KEB A;  3QGT A;  4ELH A;  5ECC A;  3RO9 A;  4KD7 A;  3QLS A;  4Q6A A;  1BOZ A;  3DG8 A;  1RB3 A;  3R33 A;  2G6V A;  2FZJ A;  2QK8 A;  2H2Q A;  4XT8 A;  2W3A A;  4G8Z X;  3JSU A;  4DPD A;  4XT4 A;  1IA1 A;  1RA2 A;  4QJC A;  3DAT A;  1SEJ A;  1DYJ A;  4FGG A;  3IRO A;  3SRR X;  4X5G A;  5HT4 A;  4XRB A;  3QLX A;  4P3Q A;  3NXO A;  3FRA X;  2D5N A;  3IA5 A;  2CIG A;  2AZN A;  5HSU A;  4XT5 A;  3SQY X; 
#chains in the Genus database with same CATH homology
 3VCO A;  4QLE A;  4H98 A;  3F0X X;  1S3W A;  3NTZ A;  1DLS A;  1DAJ A;  5HSR A;  4KL9 A;  1DRA A;  4RGC A;  1S3V A;  1RX2 A;  2OBC A;  2LF1 A;  3FQ0 A;  5HQZ A;  5HUI A;  3F0V X;  4ELE A;  3F8Y A;  4QJZ D;  3QLZ A;  4HOG A;  3QL3 A;  4PSS A;  4EIG A;  3IX9 A;  3FYW X;  4FGH A;  3FY8 X;  1RX8 A;  3NZ9 X;  4TU5 X;  4XT6 A;  4KYA A;  4X5H A;  1VDR A;  1BZF A;  3FS6 A;  4KBN A;  1LUD A;  3TQ9 A;  4H95 A;  4DDR A;  1ZDR A;  4EJ1 A;  2ANQ A;  1DR1 A;  4LAE X;  1QZF A;  3JWF A;  2ZZA A;  1KMS A;  4NX6 A;  3K47 A;  3K45 A;  3JW3 A;  3FQV A;  3FRB X;  3UM6 A;  3NXX A;  3DFR A;  1S3Y A;  1HFQ A;  1RX9 A;  1VJ3 A;  1RA8 A;  4CD2 A;  4X5J A;  3FRD X;  3N0H A;  1JOL A;  3QYL A;  3NZC X;  2BL9 A;  3K2H A;  5HVE A;  4M2X A;  1IA3 A;  3TQ8 A;  3GYF A;  2W3M A;  2D0K A;  3ZPC A;  3EX8 A;  4KLX A;  2XW7 A;  3KFY A;  1DR7 A;  2W9H A;  4EIL A;  3QFX A;  4ECK A;  3I8A X;  5U26 A;  2KGK A;  1RC4 A;  3TQA A;  1DDS A;  5HT5 A;  4IXF X;  3FQC A;  3EEJ A;  1DIS A;  4OR7 A;  3NXT A;  1LY3 A;  3EEM A;  4KAK A;  2W9S A;  4XE6 X;  3SH2 A;  1RX6 A;  3NRR A;  3QLY A;  4Q0E A;  4EIZ A;  4DFR A;  1AI9 A;  3INV A;  5HI6 A;  3QLR A;  3KJR A;  3S9U A;  1RA3 A;  3QYO A;  3M08 A;  4DPH A;  4M6K A;  3JWC A;  2BLC A;  4FHB A;  3NXY A;  3EEK A;  5CCC A;  4XEC X;  2ANO A;  3QLW A;  1DIU A;  3RG9 A;  3SAI A;  4DP3 A;  4KJJ A;  5JA3 A;  3IRM A;  4OSG A;  4H96 A;  3IRN A;  3FY9 X;  1KLK A;  4G3M A;  3GHC A;  3F8Z A;  3JW5 A;  2HM9 A;  3DL5 A;  3TD8 A;  3HJ3 A;  3GHW A;  3JVX A;  2FZI A;  1DYI A;  3SRQ X;  1DRE A;  3DL6 A;  3K74 A;  3IA4 A;  1JOM A;  5HQY A;  3GI2 A;  4PTH A;  8DFR A;  5E8Q A;  1RD7 A;  2W3B A;  3SA2 A;  4ELG A;  3S7A A;  1CD2 A;  1TDR A;  1DG8 A;  3JWK A;  5CC9 A;  3NXV A;  4KFJ A;  3FL8 A;  2OIP A;  1RA9 A;  4P68 A;  3DRC A;  1DG7 A;  4P3R A;  1HFR A;  1S3U A;  4I1N A;  5HPB A;  4ELF A;  1DHF A;  3FQO A;  1RX1 A;  4GH8 A;  1RA1 A;  4PSY A;  1J3K A;  3F0Q X;  1DDR A;  3NXR A;  2HQP A;  1RG7 A;  4PDJ A;  5HVB A;  2FZH A;  1PD8 A;  3E0B A;  3F91 A;  4QHV A;  2DHF A;  2C2S A;  1DR5 A;  3TQB A;  4M6L A;  3OAF A;  3NZD A;  4QLF A;  2GD9 A;  1DR3 A;  1U70 A;  4KM2 A;  1M7A A;  1OHK A;  4QI9 A;  3F0B X;  3UM5 A;  1DR2 A;  3EEL A;  3SGY A;  3D80 A;  1RX7 A;  1MVS A;  3SRU X;  5ECX A;  3QG2 A;  3JTW A;  1IA4 A;  1RB2 A;  2W9T A;  3M09 A;  4I13 A;  4Q67 A;  1DRF A;  2CD2 A;  3FRE X;  4X5I A;  4PTJ A;  3SR5 X;  3FQZ A;  3SRS X;  7DFR A;  3DAU A;  1J3J A;  2W3W A;  1D1G A;  4KJK A;  5JG0 X;  3F0S X;  4HA7 A;  2HXV A;  3KJS A;  4KJL A;  1RX5 A;  2B3Z A;  1J3I A;  1U71 A;  3SA1 A;  2BLA A;  3NZ6 X;  4QLG A;  1DYH A;  1PDB A;  3FRF X;  4IXG X;  1DYR A;  1U72 A;  1JUV A;  1E26 A;  1AO8 A;  4LAG X;  5HF2 X;  2W9G A;  4G95 A;  3EIG A;  1RX4 A;  1OHJ A;  1M78 A;  2O7P A;  4IXE D;  1KMV A;  3CD2 A;  3Q1H A;  4M7U A;  3CLB A;  3NZA X;  3CSE A;  3L3R A;  1DR4 A;  2L28 A;  1DRB A;  3CL9 A;  5HF0 X;  2INQ A;  3QL0 A;  3KY8 A;  3NZB X;  3I3R A;  1DR6 A;  4KY8 A;  2W3V A;  3KGY A;  4XT7 A;  4KY4 A;  6DFR A;  1LY4 A;  3SRW X;  3GHV A;  2DRC A;  4LEK X;  1RX3 A;  3JWM A;  2C2T A;  4KM0 A;  2JYB A;  4M6J A;  1DHJ A;  2BLB A;  3LG4 A;  4NX7 A;  1M79 A;  3HBB A;  3ZPG A;  1CZ3 A;  2ITH A;  4HA9 A;  5EAJ A;  5DXV A;  1RF7 A;  3DGA A;  5U27 A;  1AOE A;  4ELB A;  3D84 X;  4Q0D A;  4HOE A;  1DF7 A;  3F0U X;  3OCH A;  1DLR A;  3FQF A;  3FL9 A;  4LAH X;  1RH3 A;  1PD9 A;  4X5F A;  1DG5 A;  1DRH A;  5DFR A;  4P66 A;  2P4G A;  4H97 A;  1HFP A;  4PST A;  4M7V A;  1RE7 A;  1YHO A;  4HOF A;  3S3V A;  1MVT A;  3FYV X;  4KNE A;  5FDA A;  1DHI A;  3UM8 A;  1IA2 A;  3ROA A;  3NU0 A;  4KEB A;  3QGT A;  4ELH A;  5ECC A;  3RO9 A;  4KD7 A;  3QLS A;  4Q6A A;  1BOZ A;  3DG8 A;  1RB3 A;  3R33 A;  2G6V A;  2FZJ A;  2QK8 A;  2H2Q A;  4XT8 A;  2W3A A;  4G8Z X;  3JSU A;  4DPD A;  4XT4 A;  1IA1 A;  1RA2 A;  4QJC A;  3DAT A;  1SEJ A;  1DYJ A;  4FGG A;  3IRO A;  3SRR X;  4X5G A;  5HT4 A;  4XRB A;  3QLX A;  4P3Q A;  3NXO A;  3FRA X;  2D5N A;  3IA5 A;  2CIG A;  2AZN A;  5HSU A;  4XT5 A;  3SQY X;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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