1RG7A

Dihydrofolate reductase complexed with methotrexate
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
source organism Escherichia coli
publication title Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
pubmed doi rcsb
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 45
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1996-11-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1rg7A00
3NZ6X 3F0SX 3QFXA 3SA1A 4PDJA 1RB2A 1VJ3A 3KY8A 2DHFA 4PSYA 1PD9A 1RH3A 4DPDA 2HM9A 1DR4A 4I1NA 8DFRA 1DHJA 1DISA 3GHCA 4IXGX 1HFRA 3QLRA 4P3RA 1U71A 4XT6A 2L28A 5EAJA 1J3IA 4Q0EA 4XE6X 1S3YA 3SH2A 1DR3A 1JOMA 3JWCA 5HF2X 2O7PA 3HBBA 4H96A 4CD2A 3ROAA 4EILA 4NX7A 4IXFX 3TQ9A 2BLAA 1S3WA 1RF7A 3FQOA 4M6KA 4IXED 3DATA 3S9UA 1RX6A 4DDRA 1DDSA 1PD8A 2GD9A 1RX8A 1DRBA 3NZ9X 4XT8A 4KY4A 3JWMA 4M2XA 3CSEA 2INQA 1DYRA 4XT4A 1PDBA 1LUDA 3QLZA 4FGGA 1SEJA 3QLXA 1RA3A 2CD2A 3DG8A 3LG4A 4HA9A 3DFRA 4RGCA 3QLSA 1BOZA 4XRBA 5FDAA 3OCHA 1CD2A 4LEKX 3SQYX 1IA2A 3F0BX 1DG8A 3NZDA 3ZPCA 3NXOA 4G3MA 2W9GA 4M6LA 5HF0X 4P68A 3TQ8A 1OHKA 3GHWA 3SRRX 4NX6A 3Q1HA 3QGTA 1TDRA 3SA2A 4HOFA 1RA8A 1RX2A 1VDRA 4KM0A 3NZCX 3NXYA 5HSUA 3K74A 4DP3A 2QK8A 2W3BA 5HQZA 1JUVA 1RD7A 2HXVA 4M6JA 3L3RA 3EIGA 3KJRA 2BLCA 3FYVX 5HUIA 2AZNA 3NRRA 5HPBA 3IA5A 4KNEA 1MVSA 5DFRA 5JG0X 4QLGA 4H95A 2ANQA 4M7UA 1RB3A 4OSGA 4LAEX 1DREA 1DF7A 3QLWA 3EX8A 1RE7A 2OBCA 4Q67A 4ELBA 2FZIA 3JW3A 4H98A 3CL9A 3QG2A 3DL6A 7DFRA 2W9TA 3K45A 4HOGA 3TQBA 1DG7A 1LY3A 1RX3A 3NXXA 3D80A 2W3VA 4DFRA 2FZJA 1DIUA 2ANOA 3VCOA 1DYJA 2FZHA 4I13A 3KFYA 4ELGA 3NXVA 5CC9A 3FS6A 2HQPA 2H2QA 1CZ3A 3IA4A 4Q0DA 3KGYA 4EIGA 4QHVA 3CLBA 1DHIA 3FYWX 3EEJA 2D5NA 1DR1A 3JWFA 3QL0A 4X5GA 5HT5A 3IX9A 3OAFA 1RX5A 1HFQA 1J3KA 3FQZA 3F0UX 4P3QA 1DR2A 3NU0A 1D1GA 3NXTA 3NZBX 1J3JA 1BZFA 3NZAX 3EEMA 4KFJA 2DRCA 2KGKA 1U72A 3FQVA 5HT4A 3FREX 3DGAA 2B3ZA 3D84X 3DL5A 1JOLA 1IA3A 3IRMA 4ECKA 4DPHA 3GHVA 4GH8A 4QLFA 5HSRA 1IA4A 3UM5A 2ZZAA 1KLKA 1RX4A 1DR7A 3K47A 3RO9A 4QLEA 5HI6A 3SRWX 4KD7A 3UM6A 4QI9A 1DYHA 1RX1A 3F0QX 2C2SA 3I3RA 1KMVA 3KJSA 3DAUA 1M79A 1DYIA 1DRHA 3FY9X 4G95A 3EEKA 1RG7A 3SRSX 1DDRA 3E0BA 1MVTA 3QLYA 4KY8A 3JTWA 4KJLA 1S3UA 3IRNA 4LAGX 1AOEA 3ZPGA 1HFPA 1DRAA 4HA7A 3F0VX 3JWKA 3SGYA 4Q6AA 1AI9A 1DR5A 5JA3A 3UM8A 3FL9A 1E26A 2BLBA 3FRAX 4PSTA 3F0XX 1DLSA 4TU5X 3M09A 4LAHX 1DLRA 2W9SA 3GI2A 3JVXA 1QZFA 3SR5X 3SRUX 3DRCA 2W9HA 2D0KA 3N0HA 5HQYA 1AO8A 3F8YA 1OHJA 1DHFA 3FY8X 3FRFX 3I8AX 4XT7A 2W3WA 1IA1A 2OIPA 4X5JA 2W3MA 3F91A 4XECX 1RX7A 1DRFA 3IROA 2BL9A 3FRBX 5U27A 4EIZA 4FGHA 4KJJA 1YHOA 5E8QA 4KJKA 1DAJA 4X5IA 3QL3A 3NXRA 3INVA 5ECCA 2CIGA 4PTHA 3QYOA 1LY4A 2LF1A 4PSSA 4OR7A 1U70A 4FHBA 1DR6A 1RX9A 1KMSA 1M78A 3FQ0A 3FQFA 4P66A 3SRQX 4H97A 4M7VA 4G8ZX 4QJZD 1M7AA 3K2HA 3TQAA 3R33A 2ITHA 1RA2A 4EJ1A 3S3VA 3FRDX 4ELHA 3HJ3A 4KAKA 3JW5A 4X5FA 6DFRA 1DG5A 5ECXA 5HVBA 4KEBA 3JSUA 2P4GA 2JYBA 2C2TA 3M08A 4KM2A 3FQCA 5HVEA 1RC4A 3SAIA 4KYAA 2G6VA 3NTZA 4KL9A 4XT5A 4KLXA 4X5HA 3QYLA 4ELEA 4PTJA 3GYFA 3EELA 3CD2A 4QJCA 3RG9A 4ELFA 5U26A 1ZDRA 1RA9A 1S3VA 5CCCA 3TD8A 3S7AA 4KBNA 2W3AA 2XW7A 3F8ZA 3FL8A 5DXVA 1RA1A 4HOEA
chains in the Genus database with same CATH superfamily
3NZ6X 3F0SX 3QFXA 3SA1A 4PDJA 1RB2A 1VJ3A 3KY8A 2DHFA 4PSYA 1PD9A 1RH3A 4DPDA 2HM9A 1DR4A 4I1NA 8DFRA 1DHJA 1DISA 3GHCA 4IXGX 1HFRA 3QLRA 4P3RA 1U71A 4XT6A 2L28A 5EAJA 1J3IA 4Q0EA 4XE6X 1S3YA 3SH2A 1DR3A 1JOMA 3JWCA 5HF2X 2O7PA 3HBBA 4H96A 4CD2A 3ROAA 4EILA 4NX7A 4IXFX 3TQ9A 2BLAA 1S3WA 1RF7A 3FQOA 4M6KA 4IXED 3DATA 3S9UA 1RX6A 4DDRA 1DDSA 1PD8A 2GD9A 1RX8A 1DRBA 3NZ9X 4XT8A 4KY4A 3JWMA 4M2XA 3CSEA 2INQA 1DYRA 4XT4A 1PDBA 1LUDA 3QLZA 4FGGA 1SEJA 3QLXA 1RA3A 2CD2A 3DG8A 3LG4A 4HA9A 3DFRA 4RGCA 3QLSA 1BOZA 4XRBA 5FDAA 3OCHA 1CD2A 4LEKX 3SQYX 1IA2A 3F0BX 1DG8A 3NZDA 3ZPCA 3NXOA 4G3MA 2W9GA 4M6LA 5HF0X 4P68A 3TQ8A 1OHKA 3GHWA 3SRRX 4NX6A 3Q1HA 3QGTA 1TDRA 3SA2A 4HOFA 1RA8A 1RX2A 1VDRA 4KM0A 3NZCX 3NXYA 5HSUA 3K74A 4DP3A 2QK8A 2W3BA 5HQZA 1JUVA 1RD7A 2HXVA 4M6JA 3L3RA 3EIGA 3KJRA 2BLCA 3FYVX 5HUIA 2AZNA 3NRRA 5HPBA 3IA5A 4KNEA 1MVSA 5DFRA 5JG0X 4QLGA 4H95A 2ANQA 4M7UA 1RB3A 4OSGA 4LAEX 1DREA 1DF7A 3QLWA 3EX8A 1RE7A 2OBCA 4Q67A 4ELBA 2FZIA 3JW3A 4H98A 3CL9A 3QG2A 3DL6A 7DFRA 2W9TA 3K45A 4HOGA 3TQBA 1DG7A 1LY3A 1RX3A 3NXXA 3D80A 2W3VA 4DFRA 2FZJA 1DIUA 2ANOA 3VCOA 1DYJA 2FZHA 4I13A 3KFYA 4ELGA 3NXVA 5CC9A 3FS6A 2HQPA 2H2QA 1CZ3A 3IA4A 4Q0DA 3KGYA 4EIGA 4QHVA 3CLBA 1DHIA 3FYWX 3EEJA 2D5NA 1DR1A 3JWFA 3QL0A 4X5GA 5HT5A 3IX9A 3OAFA 1RX5A 1HFQA 1J3KA 3FQZA 3F0UX 4P3QA 1DR2A 3NU0A 1D1GA 3NXTA 3NZBX 1J3JA 1BZFA 3NZAX 3EEMA 4KFJA 2DRCA 2KGKA 1U72A 3FQVA 5HT4A 3FREX 3DGAA 2B3ZA 3D84X 3DL5A 1JOLA 1IA3A 3IRMA 4ECKA 4DPHA 3GHVA 4GH8A 4QLFA 5HSRA 1IA4A 3UM5A 2ZZAA 1KLKA 1RX4A 1DR7A 3K47A 3RO9A 4QLEA 5HI6A 3SRWX 4KD7A 3UM6A 4QI9A 1DYHA 1RX1A 3F0QX 2C2SA 3I3RA 1KMVA 3KJSA 3DAUA 1M79A 1DYIA 1DRHA 3FY9X 4G95A 3EEKA 1RG7A 3SRSX 1DDRA 3E0BA 1MVTA 3QLYA 4KY8A 3JTWA 4KJLA 1S3UA 3IRNA 4LAGX 1AOEA 3ZPGA 1HFPA 1DRAA 4HA7A 3F0VX 3JWKA 3SGYA 4Q6AA 1AI9A 1DR5A 5JA3A 3UM8A 3FL9A 1E26A 2BLBA 3FRAX 4PSTA 3F0XX 1DLSA 4TU5X 3M09A 4LAHX 1DLRA 2W9SA 3GI2A 3JVXA 1QZFA 3SR5X 3SRUX 3DRCA 2W9HA 2D0KA 3N0HA 5HQYA 1AO8A 3F8YA 1OHJA 1DHFA 3FY8X 3FRFX 3I8AX 4XT7A 2W3WA 1IA1A 2OIPA 4X5JA 2W3MA 3F91A 4XECX 1RX7A 1DRFA 3IROA 2BL9A 3FRBX 5U27A 4EIZA 4FGHA 4KJJA 1YHOA 5E8QA 4KJKA 1DAJA 4X5IA 3QL3A 3NXRA 3INVA 5ECCA 2CIGA 4PTHA 3QYOA 1LY4A 2LF1A 4PSSA 4OR7A 1U70A 4FHBA 1DR6A 1RX9A 1KMSA 1M78A 3FQ0A 3FQFA 4P66A 3SRQX 4H97A 4M7VA 4G8ZX 4QJZD 1M7AA 3K2HA 3TQAA 3R33A 2ITHA 1RA2A 4EJ1A 3S3VA 3FRDX 4ELHA 3HJ3A 4KAKA 3JW5A 4X5FA 6DFRA 1DG5A 5ECXA 5HVBA 4KEBA 3JSUA 2P4GA 2JYBA 2C2TA 3M08A 4KM2A 3FQCA 5HVEA 1RC4A 3SAIA 4KYAA 2G6VA 3NTZA 4KL9A 4XT5A 4KLXA 4X5HA 3QYLA 4ELEA 4PTJA 3GYFA 3EELA 3CD2A 4QJCA 3RG9A 4ELFA 5U26A 1ZDRA 1RA9A 1S3VA 5CCCA 3TD8A 3S7AA 4KBNA 2W3AA 2XW7A 3F8ZA 3FL8A 5DXVA 1RA1A 4HOEA
chains in the Genus database with same CATH topology
3NZ6X 3F0SX 3QFXA 3SA1A 4PDJA 1RB2A 1VJ3A 3KY8A 2DHFA 4PSYA 1PD9A 1RH3A 4DPDA 2HM9A 1DR4A 4I1NA 8DFRA 1DHJA 1DISA 3GHCA 4IXGX 1HFRA 3QLRA 4P3RA 1U71A 4XT6A 2L28A 5EAJA 1J3IA 4Q0EA 4XE6X 1S3YA 3SH2A 1DR3A 1JOMA 3JWCA 5HF2X 2O7PA 3HBBA 4H96A 4CD2A 3ROAA 4EILA 4NX7A 4IXFX 3TQ9A 2BLAA 1S3WA 1RF7A 3FQOA 4M6KA 4IXED 3DATA 3S9UA 1RX6A 4DDRA 1DDSA 1PD8A 2GD9A 1RX8A 1DRBA 3NZ9X 4XT8A 4KY4A 3JWMA 4M2XA 3CSEA 2INQA 1DYRA 4XT4A 1PDBA 1LUDA 3QLZA 4FGGA 1SEJA 3QLXA 1RA3A 2CD2A 3DG8A 3LG4A 4HA9A 3DFRA 4RGCA 3QLSA 1BOZA 4XRBA 5FDAA 3OCHA 1CD2A 4LEKX 3SQYX 1IA2A 3F0BX 1DG8A 3NZDA 3ZPCA 3NXOA 4G3MA 2W9GA 4M6LA 5HF0X 4P68A 3TQ8A 1OHKA 3GHWA 3SRRX 4NX6A 3Q1HA 3QGTA 1TDRA 3SA2A 4HOFA 1RA8A 1RX2A 1VDRA 4KM0A 3NZCX 3NXYA 5HSUA 3K74A 4DP3A 2QK8A 2W3BA 5HQZA 1JUVA 1RD7A 2HXVA 4M6JA 3L3RA 3EIGA 3KJRA 2BLCA 3FYVX 5HUIA 2AZNA 3NRRA 5HPBA 3IA5A 4KNEA 1MVSA 5DFRA 5JG0X 4QLGA 4H95A 2ANQA 4M7UA 1RB3A 4OSGA 4LAEX 1DREA 1DF7A 3QLWA 3EX8A 1RE7A 2OBCA 4Q67A 4ELBA 2FZIA 3JW3A 4H98A 3CL9A 3QG2A 3DL6A 7DFRA 2W9TA 3K45A 4HOGA 3TQBA 1DG7A 1LY3A 1RX3A 3NXXA 3D80A 2W3VA 4DFRA 2FZJA 1DIUA 2ANOA 3VCOA 1DYJA 2FZHA 4I13A 3KFYA 4ELGA 3NXVA 5CC9A 3FS6A 2HQPA 2H2QA 1CZ3A 3IA4A 4Q0DA 3KGYA 4EIGA 4QHVA 3CLBA 1DHIA 3FYWX 3EEJA 2D5NA 1DR1A 3JWFA 3QL0A 4X5GA 5HT5A 3IX9A 3OAFA 1RX5A 1HFQA 1J3KA 3FQZA 3F0UX 4P3QA 1DR2A 3NU0A 1D1GA 3NXTA 3NZBX 1J3JA 1BZFA 3NZAX 3EEMA 4KFJA 2DRCA 2KGKA 1U72A 3FQVA 5HT4A 3FREX 3DGAA 2B3ZA 3D84X 3DL5A 1JOLA 1IA3A 3IRMA 4ECKA 4DPHA 3GHVA 4GH8A 4QLFA 5HSRA 1IA4A 3UM5A 2ZZAA 1KLKA 1RX4A 1DR7A 3K47A 3RO9A 4QLEA 5HI6A 3SRWX 4KD7A 3UM6A 4QI9A 1DYHA 1RX1A 3F0QX 2C2SA 3I3RA 1KMVA 3KJSA 3DAUA 1M79A 1DYIA 1DRHA 3FY9X 4G95A 3EEKA 1RG7A 3SRSX 1DDRA 3E0BA 1MVTA 3QLYA 4KY8A 3JTWA 4KJLA 1S3UA 3IRNA 4LAGX 1AOEA 3ZPGA 1HFPA 1DRAA 4HA7A 3F0VX 3JWKA 3SGYA 4Q6AA 1AI9A 1DR5A 5JA3A 3UM8A 3FL9A 1E26A 2BLBA 3FRAX 4PSTA 3F0XX 1DLSA 4TU5X 3M09A 4LAHX 1DLRA 2W9SA 3GI2A 3JVXA 1QZFA 3SR5X 3SRUX 3DRCA 2W9HA 2D0KA 3N0HA 5HQYA 1AO8A 3F8YA 1OHJA 1DHFA 3FY8X 3FRFX 3I8AX 4XT7A 2W3WA 1IA1A 2OIPA 4X5JA 2W3MA 3F91A 4XECX 1RX7A 1DRFA 3IROA 2BL9A 3FRBX 5U27A 4EIZA 4FGHA 4KJJA 1YHOA 5E8QA 4KJKA 1DAJA 4X5IA 3QL3A 3NXRA 3INVA 5ECCA 2CIGA 4PTHA 3QYOA 1LY4A 2LF1A 4PSSA 4OR7A 1U70A 4FHBA 1DR6A 1RX9A 1KMSA 1M78A 3FQ0A 3FQFA 4P66A 3SRQX 4H97A 4M7VA 4G8ZX 4QJZD 1M7AA 3K2HA 3TQAA 3R33A 2ITHA 1RA2A 4EJ1A 3S3VA 3FRDX 4ELHA 3HJ3A 4KAKA 3JW5A 4X5FA 6DFRA 1DG5A 5ECXA 5HVBA 4KEBA 3JSUA 2P4GA 2JYBA 2C2TA 3M08A 4KM2A 3FQCA 5HVEA 1RC4A 3SAIA 4KYAA 2G6VA 3NTZA 4KL9A 4XT5A 4KLXA 4X5HA 3QYLA 4ELEA 4PTJA 3GYFA 3EELA 3CD2A 4QJCA 3RG9A 4ELFA 5U26A 1ZDRA 1RA9A 1S3VA 5CCCA 3TD8A 3S7AA 4KBNA 2W3AA 2XW7A 3F8ZA 3FL8A 5DXVA 1RA1A 4HOEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NZ6 X;  3F0S X;  3QFX A;  3SA1 A;  4PDJ A;  1RB2 A;  1VJ3 A;  3KY8 A;  2DHF A;  4PSY A;  1PD9 A;  1RH3 A;  4DPD A;  2HM9 A;  1DR4 A;  4I1N A;  8DFR A;  1DHJ A;  1DIS A;  3GHC A;  4IXG X;  1HFR A;  3QLR A;  4P3R A;  1U71 A;  4XT6 A;  2L28 A;  5EAJ A;  1J3I A;  4Q0E A;  4XE6 X;  1S3Y A;  3SH2 A;  1DR3 A;  1JOM A;  3JWC A;  5HF2 X;  2O7P A;  3HBB A;  4H96 A;  4CD2 A;  3ROA A;  4EIL A;  4NX7 A;  4IXF X;  3TQ9 A;  2BLA A;  1S3W A;  1RF7 A;  3FQO A;  4M6K A;  4IXE D;  3DAT A;  3S9U A;  1RX6 A;  4DDR A;  1DDS A;  1PD8 A;  2GD9 A;  1RX8 A;  1DRB A;  3NZ9 X;  4XT8 A;  4KY4 A;  3JWM A;  4M2X A;  3CSE A;  2INQ A;  1DYR A;  4XT4 A;  1PDB A;  1LUD A;  3QLZ A;  4FGG A;  1SEJ A;  3QLX A;  1RA3 A;  2CD2 A;  3DG8 A;  3LG4 A;  4HA9 A;  3DFR A;  4RGC A;  3QLS A;  1BOZ A;  4XRB A;  5FDA A;  3OCH A;  1CD2 A;  4LEK X;  3SQY X;  1IA2 A;  3F0B X;  1DG8 A;  3NZD A;  3ZPC A;  3NXO A;  4G3M A;  2W9G A;  4M6L A;  5HF0 X;  4P68 A;  3TQ8 A;  1OHK A;  3GHW A;  3SRR X;  4NX6 A;  3Q1H A;  3QGT A;  1TDR A;  3SA2 A;  4HOF A;  1RA8 A;  1RX2 A;  1VDR A;  4KM0 A;  3NZC X;  3NXY A;  5HSU A;  3K74 A;  4DP3 A;  2QK8 A;  2W3B A;  5HQZ A;  1JUV A;  1RD7 A;  2HXV A;  4M6J A;  3L3R A;  3EIG A;  3KJR A;  2BLC A;  3FYV X;  5HUI A;  2AZN A;  3NRR A;  5HPB A;  3IA5 A;  4KNE A;  1MVS A;  5DFR A;  5JG0 X;  4QLG A;  4H95 A;  2ANQ A;  4M7U A;  1RB3 A;  4OSG A;  4LAE X;  1DRE A;  1DF7 A;  3QLW A;  3EX8 A;  1RE7 A;  2OBC A;  4Q67 A;  4ELB A;  2FZI A;  3JW3 A;  4H98 A;  3CL9 A;  3QG2 A;  3DL6 A;  7DFR A;  2W9T A;  3K45 A;  4HOG A;  3TQB A;  1DG7 A;  1LY3 A;  1RX3 A;  3NXX A;  3D80 A;  2W3V A;  4DFR A;  2FZJ A;  1DIU A;  2ANO A;  3VCO A;  1DYJ A;  2FZH A;  4I13 A;  3KFY A;  4ELG A;  3NXV A;  5CC9 A;  3FS6 A;  2HQP A;  2H2Q A;  1CZ3 A;  3IA4 A;  4Q0D A;  3KGY A;  4EIG A;  4QHV A;  3CLB A;  1DHI A;  3FYW X;  3EEJ A;  2D5N A;  1DR1 A;  3JWF A;  3QL0 A;  4X5G A;  5HT5 A;  3IX9 A;  3OAF A;  1RX5 A;  1HFQ A;  1J3K A;  3FQZ A;  3F0U X;  4P3Q A;  1DR2 A;  3NU0 A;  1D1G A;  3NXT A;  3NZB X;  1J3J A;  1BZF A;  3NZA X;  3EEM A;  4KFJ A;  2DRC A;  2KGK A;  1U72 A;  3FQV A;  5HT4 A;  3FRE X;  3DGA A;  2B3Z A;  3D84 X;  3DL5 A;  1JOL A;  1IA3 A;  3IRM A;  4ECK A;  4DPH A;  3GHV A;  4GH8 A;  4QLF A;  5HSR A;  1IA4 A;  3UM5 A;  2ZZA A;  1KLK A;  1RX4 A;  1DR7 A;  3K47 A;  3RO9 A;  4QLE A;  5HI6 A;  3SRW X;  4KD7 A;  3UM6 A;  4QI9 A;  1DYH A;  1RX1 A;  3F0Q X;  2C2S A;  3I3R A;  1KMV A;  3KJS A;  3DAU A;  1M79 A;  1DYI A;  1DRH A;  3FY9 X;  4G95 A;  3EEK A;  1RG7 A;  3SRS X;  1DDR A;  3E0B A;  1MVT A;  3QLY A;  4KY8 A;  3JTW A;  4KJL A;  1S3U A;  3IRN A;  4LAG X;  1AOE A;  3ZPG A;  1HFP A;  1DRA A;  4HA7 A;  3F0V X;  3JWK A;  3SGY A;  4Q6A A;  1AI9 A;  1DR5 A;  5JA3 A;  3UM8 A;  3FL9 A;  1E26 A;  2BLB A;  3FRA X;  4PST A;  3F0X X;  1DLS A;  4TU5 X;  3M09 A;  4LAH X;  1DLR A;  2W9S A;  3GI2 A;  3JVX A;  1QZF A;  3SR5 X;  3SRU X;  3DRC A;  2W9H A;  2D0K A;  3N0H A;  5HQY A;  1AO8 A;  3F8Y A;  1OHJ A;  1DHF A;  3FY8 X;  3FRF X;  3I8A X;  4XT7 A;  2W3W A;  1IA1 A;  2OIP A;  4X5J A;  2W3M A;  3F91 A;  4XEC X;  1RX7 A;  1DRF A;  3IRO A;  2BL9 A;  3FRB X;  5U27 A;  4EIZ A;  4FGH A;  4KJJ A;  1YHO A;  5E8Q A;  4KJK A;  1DAJ A;  4X5I A;  3QL3 A;  3NXR A;  3INV A;  5ECC A;  2CIG A;  4PTH A;  3QYO A;  1LY4 A;  2LF1 A;  4PSS A;  4OR7 A;  1U70 A;  4FHB A;  1DR6 A;  1RX9 A;  1KMS A;  1M78 A;  3FQ0 A;  3FQF A;  4P66 A;  3SRQ X;  4H97 A;  4M7V A;  4G8Z X;  4QJZ D;  1M7A A;  3K2H A;  3TQA A;  3R33 A;  2ITH A;  1RA2 A;  4EJ1 A;  3S3V A;  3FRD X;  4ELH A;  3HJ3 A;  4KAK A;  3JW5 A;  4X5F A;  6DFR A;  1DG5 A;  5ECX A;  5HVB A;  4KEB A;  3JSU A;  2P4G A;  2JYB A;  2C2T A;  3M08 A;  4KM2 A;  3FQC A;  5HVE A;  1RC4 A;  3SAI A;  4KYA A;  2G6V A;  3NTZ A;  4KL9 A;  4XT5 A;  4KLX A;  4X5H A;  3QYL A;  4ELE A;  4PTJ A;  3GYF A;  3EEL A;  3CD2 A;  4QJC A;  3RG9 A;  4ELF A;  5U26 A;  1ZDR A;  1RA9 A;  1S3V A;  5CCC A;  3TD8 A;  3S7A A;  4KBN A;  2W3A A;  2XW7 A;  3F8Z A;  3FL8 A;  5DXV A;  1RA1 A;  4HOE A; 
#chains in the Genus database with same CATH topology
 3NZ6 X;  3F0S X;  3QFX A;  3SA1 A;  4PDJ A;  1RB2 A;  1VJ3 A;  3KY8 A;  2DHF A;  4PSY A;  1PD9 A;  1RH3 A;  4DPD A;  2HM9 A;  1DR4 A;  4I1N A;  8DFR A;  1DHJ A;  1DIS A;  3GHC A;  4IXG X;  1HFR A;  3QLR A;  4P3R A;  1U71 A;  4XT6 A;  2L28 A;  5EAJ A;  1J3I A;  4Q0E A;  4XE6 X;  1S3Y A;  3SH2 A;  1DR3 A;  1JOM A;  3JWC A;  5HF2 X;  2O7P A;  3HBB A;  4H96 A;  4CD2 A;  3ROA A;  4EIL A;  4NX7 A;  4IXF X;  3TQ9 A;  2BLA A;  1S3W A;  1RF7 A;  3FQO A;  4M6K A;  4IXE D;  3DAT A;  3S9U A;  1RX6 A;  4DDR A;  1DDS A;  1PD8 A;  2GD9 A;  1RX8 A;  1DRB A;  3NZ9 X;  4XT8 A;  4KY4 A;  3JWM A;  4M2X A;  3CSE A;  2INQ A;  1DYR A;  4XT4 A;  1PDB A;  1LUD A;  3QLZ A;  4FGG A;  1SEJ A;  3QLX A;  1RA3 A;  2CD2 A;  3DG8 A;  3LG4 A;  4HA9 A;  3DFR A;  4RGC A;  3QLS A;  1BOZ A;  4XRB A;  5FDA A;  3OCH A;  1CD2 A;  4LEK X;  3SQY X;  1IA2 A;  3F0B X;  1DG8 A;  3NZD A;  3ZPC A;  3NXO A;  4G3M A;  2W9G A;  4M6L A;  5HF0 X;  4P68 A;  3TQ8 A;  1OHK A;  3GHW A;  3SRR X;  4NX6 A;  3Q1H A;  3QGT A;  1TDR A;  3SA2 A;  4HOF A;  1RA8 A;  1RX2 A;  1VDR A;  4KM0 A;  3NZC X;  3NXY A;  5HSU A;  3K74 A;  4DP3 A;  2QK8 A;  2W3B A;  5HQZ A;  1JUV A;  1RD7 A;  2HXV A;  4M6J A;  3L3R A;  3EIG A;  3KJR A;  2BLC A;  3FYV X;  5HUI A;  2AZN A;  3NRR A;  5HPB A;  3IA5 A;  4KNE A;  1MVS A;  5DFR A;  5JG0 X;  4QLG A;  4H95 A;  2ANQ A;  4M7U A;  1RB3 A;  4OSG A;  4LAE X;  1DRE A;  1DF7 A;  3QLW A;  3EX8 A;  1RE7 A;  2OBC A;  4Q67 A;  4ELB A;  2FZI A;  3JW3 A;  4H98 A;  3CL9 A;  3QG2 A;  3DL6 A;  7DFR A;  2W9T A;  3K45 A;  4HOG A;  3TQB A;  1DG7 A;  1LY3 A;  1RX3 A;  3NXX A;  3D80 A;  2W3V A;  4DFR A;  2FZJ A;  1DIU A;  2ANO A;  3VCO A;  1DYJ A;  2FZH A;  4I13 A;  3KFY A;  4ELG A;  3NXV A;  5CC9 A;  3FS6 A;  2HQP A;  2H2Q A;  1CZ3 A;  3IA4 A;  4Q0D A;  3KGY A;  4EIG A;  4QHV A;  3CLB A;  1DHI A;  3FYW X;  3EEJ A;  2D5N A;  1DR1 A;  3JWF A;  3QL0 A;  4X5G A;  5HT5 A;  3IX9 A;  3OAF A;  1RX5 A;  1HFQ A;  1J3K A;  3FQZ A;  3F0U X;  4P3Q A;  1DR2 A;  3NU0 A;  1D1G A;  3NXT A;  3NZB X;  1J3J A;  1BZF A;  3NZA X;  3EEM A;  4KFJ A;  2DRC A;  2KGK A;  1U72 A;  3FQV A;  5HT4 A;  3FRE X;  3DGA A;  2B3Z A;  3D84 X;  3DL5 A;  1JOL A;  1IA3 A;  3IRM A;  4ECK A;  4DPH A;  3GHV A;  4GH8 A;  4QLF A;  5HSR A;  1IA4 A;  3UM5 A;  2ZZA A;  1KLK A;  1RX4 A;  1DR7 A;  3K47 A;  3RO9 A;  4QLE A;  5HI6 A;  3SRW X;  4KD7 A;  3UM6 A;  4QI9 A;  1DYH A;  1RX1 A;  3F0Q X;  2C2S A;  3I3R A;  1KMV A;  3KJS A;  3DAU A;  1M79 A;  1DYI A;  1DRH A;  3FY9 X;  4G95 A;  3EEK A;  1RG7 A;  3SRS X;  1DDR A;  3E0B A;  1MVT A;  3QLY A;  4KY8 A;  3JTW A;  4KJL A;  1S3U A;  3IRN A;  4LAG X;  1AOE A;  3ZPG A;  1HFP A;  1DRA A;  4HA7 A;  3F0V X;  3JWK A;  3SGY A;  4Q6A A;  1AI9 A;  1DR5 A;  5JA3 A;  3UM8 A;  3FL9 A;  1E26 A;  2BLB A;  3FRA X;  4PST A;  3F0X X;  1DLS A;  4TU5 X;  3M09 A;  4LAH X;  1DLR A;  2W9S A;  3GI2 A;  3JVX A;  1QZF A;  3SR5 X;  3SRU X;  3DRC A;  2W9H A;  2D0K A;  3N0H A;  5HQY A;  1AO8 A;  3F8Y A;  1OHJ A;  1DHF A;  3FY8 X;  3FRF X;  3I8A X;  4XT7 A;  2W3W A;  1IA1 A;  2OIP A;  4X5J A;  2W3M A;  3F91 A;  4XEC X;  1RX7 A;  1DRF A;  3IRO A;  2BL9 A;  3FRB X;  5U27 A;  4EIZ A;  4FGH A;  4KJJ A;  1YHO A;  5E8Q A;  4KJK A;  1DAJ A;  4X5I A;  3QL3 A;  3NXR A;  3INV A;  5ECC A;  2CIG A;  4PTH A;  3QYO A;  1LY4 A;  2LF1 A;  4PSS A;  4OR7 A;  1U70 A;  4FHB A;  1DR6 A;  1RX9 A;  1KMS A;  1M78 A;  3FQ0 A;  3FQF A;  4P66 A;  3SRQ X;  4H97 A;  4M7V A;  4G8Z X;  4QJZ D;  1M7A A;  3K2H A;  3TQA A;  3R33 A;  2ITH A;  1RA2 A;  4EJ1 A;  3S3V A;  3FRD X;  4ELH A;  3HJ3 A;  4KAK A;  3JW5 A;  4X5F A;  6DFR A;  1DG5 A;  5ECX A;  5HVB A;  4KEB A;  3JSU A;  2P4G A;  2JYB A;  2C2T A;  3M08 A;  4KM2 A;  3FQC A;  5HVE A;  1RC4 A;  3SAI A;  4KYA A;  2G6V A;  3NTZ A;  4KL9 A;  4XT5 A;  4KLX A;  4X5H A;  3QYL A;  4ELE A;  4PTJ A;  3GYF A;  3EEL A;  3CD2 A;  4QJC A;  3RG9 A;  4ELF A;  5U26 A;  1ZDR A;  1RA9 A;  1S3V A;  5CCC A;  3TD8 A;  3S7A A;  4KBN A;  2W3A A;  2XW7 A;  3F8Z A;  3FL8 A;  5DXV A;  1RA1 A;  4HOE A; 
#chains in the Genus database with same CATH homology
 3NZ6 X;  3F0S X;  3QFX A;  3SA1 A;  4PDJ A;  1RB2 A;  1VJ3 A;  3KY8 A;  2DHF A;  4PSY A;  1PD9 A;  1RH3 A;  4DPD A;  2HM9 A;  1DR4 A;  4I1N A;  8DFR A;  1DHJ A;  1DIS A;  3GHC A;  4IXG X;  1HFR A;  3QLR A;  4P3R A;  1U71 A;  4XT6 A;  2L28 A;  5EAJ A;  1J3I A;  4Q0E A;  4XE6 X;  1S3Y A;  3SH2 A;  1DR3 A;  1JOM A;  3JWC A;  5HF2 X;  2O7P A;  3HBB A;  4H96 A;  4CD2 A;  3ROA A;  4EIL A;  4NX7 A;  4IXF X;  3TQ9 A;  2BLA A;  1S3W A;  1RF7 A;  3FQO A;  4M6K A;  4IXE D;  3DAT A;  3S9U A;  1RX6 A;  4DDR A;  1DDS A;  1PD8 A;  2GD9 A;  1RX8 A;  1DRB A;  3NZ9 X;  4XT8 A;  4KY4 A;  3JWM A;  4M2X A;  3CSE A;  2INQ A;  1DYR A;  4XT4 A;  1PDB A;  1LUD A;  3QLZ A;  4FGG A;  1SEJ A;  3QLX A;  1RA3 A;  2CD2 A;  3DG8 A;  3LG4 A;  4HA9 A;  3DFR A;  4RGC A;  3QLS A;  1BOZ A;  4XRB A;  5FDA A;  3OCH A;  1CD2 A;  4LEK X;  3SQY X;  1IA2 A;  3F0B X;  1DG8 A;  3NZD A;  3ZPC A;  3NXO A;  4G3M A;  2W9G A;  4M6L A;  5HF0 X;  4P68 A;  3TQ8 A;  1OHK A;  3GHW A;  3SRR X;  4NX6 A;  3Q1H A;  3QGT A;  1TDR A;  3SA2 A;  4HOF A;  1RA8 A;  1RX2 A;  1VDR A;  4KM0 A;  3NZC X;  3NXY A;  5HSU A;  3K74 A;  4DP3 A;  2QK8 A;  2W3B A;  5HQZ A;  1JUV A;  1RD7 A;  2HXV A;  4M6J A;  3L3R A;  3EIG A;  3KJR A;  2BLC A;  3FYV X;  5HUI A;  2AZN A;  3NRR A;  5HPB A;  3IA5 A;  4KNE A;  1MVS A;  5DFR A;  5JG0 X;  4QLG A;  4H95 A;  2ANQ A;  4M7U A;  1RB3 A;  4OSG A;  4LAE X;  1DRE A;  1DF7 A;  3QLW A;  3EX8 A;  1RE7 A;  2OBC A;  4Q67 A;  4ELB A;  2FZI A;  3JW3 A;  4H98 A;  3CL9 A;  3QG2 A;  3DL6 A;  7DFR A;  2W9T A;  3K45 A;  4HOG A;  3TQB A;  1DG7 A;  1LY3 A;  1RX3 A;  3NXX A;  3D80 A;  2W3V A;  4DFR A;  2FZJ A;  1DIU A;  2ANO A;  3VCO A;  1DYJ A;  2FZH A;  4I13 A;  3KFY A;  4ELG A;  3NXV A;  5CC9 A;  3FS6 A;  2HQP A;  2H2Q A;  1CZ3 A;  3IA4 A;  4Q0D A;  3KGY A;  4EIG A;  4QHV A;  3CLB A;  1DHI A;  3FYW X;  3EEJ A;  2D5N A;  1DR1 A;  3JWF A;  3QL0 A;  4X5G A;  5HT5 A;  3IX9 A;  3OAF A;  1RX5 A;  1HFQ A;  1J3K A;  3FQZ A;  3F0U X;  4P3Q A;  1DR2 A;  3NU0 A;  1D1G A;  3NXT A;  3NZB X;  1J3J A;  1BZF A;  3NZA X;  3EEM A;  4KFJ A;  2DRC A;  2KGK A;  1U72 A;  3FQV A;  5HT4 A;  3FRE X;  3DGA A;  2B3Z A;  3D84 X;  3DL5 A;  1JOL A;  1IA3 A;  3IRM A;  4ECK A;  4DPH A;  3GHV A;  4GH8 A;  4QLF A;  5HSR A;  1IA4 A;  3UM5 A;  2ZZA A;  1KLK A;  1RX4 A;  1DR7 A;  3K47 A;  3RO9 A;  4QLE A;  5HI6 A;  3SRW X;  4KD7 A;  3UM6 A;  4QI9 A;  1DYH A;  1RX1 A;  3F0Q X;  2C2S A;  3I3R A;  1KMV A;  3KJS A;  3DAU A;  1M79 A;  1DYI A;  1DRH A;  3FY9 X;  4G95 A;  3EEK A;  1RG7 A;  3SRS X;  1DDR A;  3E0B A;  1MVT A;  3QLY A;  4KY8 A;  3JTW A;  4KJL A;  1S3U A;  3IRN A;  4LAG X;  1AOE A;  3ZPG A;  1HFP A;  1DRA A;  4HA7 A;  3F0V X;  3JWK A;  3SGY A;  4Q6A A;  1AI9 A;  1DR5 A;  5JA3 A;  3UM8 A;  3FL9 A;  1E26 A;  2BLB A;  3FRA X;  4PST A;  3F0X X;  1DLS A;  4TU5 X;  3M09 A;  4LAH X;  1DLR A;  2W9S A;  3GI2 A;  3JVX A;  1QZF A;  3SR5 X;  3SRU X;  3DRC A;  2W9H A;  2D0K A;  3N0H A;  5HQY A;  1AO8 A;  3F8Y A;  1OHJ A;  1DHF A;  3FY8 X;  3FRF X;  3I8A X;  4XT7 A;  2W3W A;  1IA1 A;  2OIP A;  4X5J A;  2W3M A;  3F91 A;  4XEC X;  1RX7 A;  1DRF A;  3IRO A;  2BL9 A;  3FRB X;  5U27 A;  4EIZ A;  4FGH A;  4KJJ A;  1YHO A;  5E8Q A;  4KJK A;  1DAJ A;  4X5I A;  3QL3 A;  3NXR A;  3INV A;  5ECC A;  2CIG A;  4PTH A;  3QYO A;  1LY4 A;  2LF1 A;  4PSS A;  4OR7 A;  1U70 A;  4FHB A;  1DR6 A;  1RX9 A;  1KMS A;  1M78 A;  3FQ0 A;  3FQF A;  4P66 A;  3SRQ X;  4H97 A;  4M7V A;  4G8Z X;  4QJZ D;  1M7A A;  3K2H A;  3TQA A;  3R33 A;  2ITH A;  1RA2 A;  4EJ1 A;  3S3V A;  3FRD X;  4ELH A;  3HJ3 A;  4KAK A;  3JW5 A;  4X5F A;  6DFR A;  1DG5 A;  5ECX A;  5HVB A;  4KEB A;  3JSU A;  2P4G A;  2JYB A;  2C2T A;  3M08 A;  4KM2 A;  3FQC A;  5HVE A;  1RC4 A;  3SAI A;  4KYA A;  2G6V A;  3NTZ A;  4KL9 A;  4XT5 A;  4KLX A;  4X5H A;  3QYL A;  4ELE A;  4PTJ A;  3GYF A;  3EEL A;  3CD2 A;  4QJC A;  3RG9 A;  4ELF A;  5U26 A;  1ZDR A;  1RA9 A;  1S3V A;  5CCC A;  3TD8 A;  3S7A A;  4KBN A;  2W3A A;  2XW7 A;  3F8Z A;  3FL8 A;  5DXV A;  1RA1 A;  4HOE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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