1RH3A

Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (reduced form)
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 42
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1996-11-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1rh3A00
3SR5X 3FREX 4KYAA 3CLBA 1DISA 3NZAX 3TQ9A 4QLGA 1AOEA 3QL3A 3NXTA 4XRBA 4OR7A 2BLAA 4H98A 4G8ZX 1DLRA 3JTWA 5EAJA 1IA1A 2W9TA 2HXVA 3R33A 1J3KA 4KJJA 3TQAA 3IA4A 1RX8A 1DHFA 4ELHA 4QJZD 2O7PA 3ZPCA 1RE7A 3S9UA 4KLXA 1MVTA 2H2QA 8DFRA 1DYHA 3FQCA 4H95A 3NXYA 2FZHA 3KGYA 3EELA 2L28A 1S3VA 2W3WA 1PD8A 1DREA 1DLSA 3QL0A 5E8QA 3NZ9X 3EX8A 5DXVA 3OAFA 2FZIA 3S7AA 5FDAA 3FQZA 3SRQX 3QLXA 4ELBA 3L3RA 2XW7A 5HUIA 3GYFA 4Q67A 3Q1HA 3UM5A 1DAJA 1RC4A 3DL5A 4M6LA 4H96A 1RG7A 2D0KA 1DR7A 1IA2A 3QYOA 2W3MA 3NZDA 1CZ3A 1M78A 3ROAA 1RA9A 4LAHX 3D84X 3K45A 1M7AA 3JW5A 3SH2A 1S3WA 3INVA 3NXVA 3EEKA 3NXOA 1DRAA 2W9GA 1S3YA 2QK8A 1JOMA 4XT4A 3ZPGA 2W3AA 2W9HA 4KEBA 4EIZA 1RA2A 3TQBA 4M6JA 2HM9A 3N0HA 3SAIA 3E0BA 4X5FA 3QLSA 1DDSA 5HF2X 2CIGA 3KFYA 1J3IA 4M2XA 4PTHA 4P3QA 5HPBA 4XECX 3RO9A 2JYBA 3NZCX 4LAGX 4KBNA 1DRHA 1RH3A 1DYRA 2ANQA 3NZBX 1LY4A 1DRBA 1U72A 3F0BX 3OCHA 3GHWA 3GHCA 3K74A 3FY9X 3JWMA 3JWCA 4IXFX 5U27A 3QLYA 1RF7A 4EILA 3UM6A 5HQYA 5ECXA 4ECKA 2C2SA 3CL9A 3FYWX 4KY8A 1HFRA 3FYVX 1VJ3A 5HVBA 4ELEA 4I1NA 3QLZA 2W3BA 1LY3A 4QLFA 1OHKA 4HOEA 2DRCA 1DHJA 2KGKA 1DF7A 4NX6A 4EJ1A 4KNEA 2D5NA 3FRBX 4QLEA 3DATA 5DFRA 4PSYA 4KFJA 5ECCA 4Q6AA 3M09A 3SRWX 3I3RA 3FY8X 4H97A 4PSSA 4I13A 5HT5A 3NRRA 4PTJA 3SA1A 4RGCA 4P68A 4FGHA 3QYLA 2GD9A 3CSEA 5HT4A 4X5IA 3TQ8A 3DL6A 4X5JA 1DR2A 3QFXA 4XT6A 2INQA 4XE6X 7DFRA 4P3RA 3SA2A 1DHIA 4KM0A 3NTZA 3FQ0A 2ZZAA 3FQOA 1DDRA 1D1GA 4ELFA 1S3UA 1CD2A 2LF1A 3K47A 3EEJA 4OSGA 4IXGX 1JUVA 1KLKA 3I8AX 2ITHA 3RG9A 5HF0X 1J3JA 4HOFA 1DR5A 4XT5A 1KMVA 4HA7A 3QGTA 3FRFX 1RX3A 4KL9A 3NXXA 3FL9A 4DPHA 1YHOA 3K2HA 3FRAX 1M79A 1RX6A 4Q0DA 4GH8A 1RB2A 4QI9A 4X5GA 1RD7A 1VDRA 4FGGA 1LUDA 3IA5A 3F0QX 2BLBA 4IXED 5U26A 1BOZA 1AO8A 4HA9A 3SRSX 2W9SA 3M08A 1SEJA 4DDRA 2HQPA 1DG5A 2W3VA 5JG0X 2P4GA 4FHBA 1RX2A 2AZNA 4DFRA 4CD2A 3FQFA 1DR3A 4KJLA 3VCOA 3DFRA 3FRDX 3IRNA 1DG7A 1RX5A 3DRCA 3JVXA 3QLWA 1HFPA 3NXRA 1DYIA 3F0SX 4P66A 4KD7A 1E26A 1RX1A 3DAUA 3F0UX 4TU5X 3KJRA 2FZJA 2OIPA 4KAKA 1HFQA 3EEMA 1RA3A 4PDJA 4Q0EA 2OBCA 3FQVA 1IA3A 4KY4A 3QG2A 3CD2A 4M6KA 1DR1A 4NX7A 5HSRA 1BZFA 1PDBA 4QHVA 5HI6A 1AI9A 2ANOA 3GI2A 3DGAA 1U70A 1DIUA 3FS6A 3LG4A 2BLCA 3IROA 1RA8A 1MVSA 5JA3A 3IX9A 3JWFA 1RX7A 4LEKX 4LAEX 3NU0A 1RA1A 1DR4A 4G3MA 3SRRX 1RX9A 3TD8A 4ELGA 3JSUA 3DG8A 3GHVA 4X5HA 4DPDA 1JOLA 1DR6A 4HOGA 2B3ZA 3EIGA 3JW3A 2G6VA 3IRMA 1ZDRA 4DP3A 3JWKA 2BL9A 5HQZA 4G95A 3F91A 3SQYX 1DYJA 1IA4A 1TDRA 1PD9A 1RB3A 4M7VA 4PSTA 5HSUA 4M7UA 3UM8A 1KMSA 3F0VX 3HBBA 3D80A 3S3VA 4EIGA 5CCCA 3HJ3A 3F8ZA 3FL8A 3QLRA 4KJKA 4QJCA 1QZFA 5CC9A 4KM2A 3SRUX 1U71A 2CD2A 3SGYA 1RX4A 3F8YA 5HVEA 4XT8A 1OHJA 3KY8A 3NZ6X 1DG8A 2DHFA 6DFRA 1DRFA 2C2TA 4XT7A 3F0XX 3KJSA
chains in the Genus database with same CATH superfamily
3SR5X 3FREX 4KYAA 3CLBA 1DISA 3NZAX 3TQ9A 4QLGA 1AOEA 3QL3A 3NXTA 4XRBA 4OR7A 2BLAA 4H98A 4G8ZX 1DLRA 3JTWA 5EAJA 1IA1A 2W9TA 2HXVA 3R33A 1J3KA 4KJJA 3TQAA 3IA4A 1RX8A 1DHFA 4ELHA 4QJZD 2O7PA 3ZPCA 1RE7A 3S9UA 4KLXA 1MVTA 2H2QA 8DFRA 1DYHA 3FQCA 4H95A 3NXYA 2FZHA 3KGYA 3EELA 2L28A 1S3VA 2W3WA 1PD8A 1DREA 1DLSA 3QL0A 5E8QA 3NZ9X 3EX8A 5DXVA 3OAFA 2FZIA 3S7AA 5FDAA 3FQZA 3SRQX 3QLXA 4ELBA 3L3RA 2XW7A 5HUIA 3GYFA 4Q67A 3Q1HA 3UM5A 1DAJA 1RC4A 3DL5A 4M6LA 4H96A 1RG7A 2D0KA 1DR7A 1IA2A 3QYOA 2W3MA 3NZDA 1CZ3A 1M78A 3ROAA 1RA9A 4LAHX 3D84X 3K45A 1M7AA 3JW5A 3SH2A 1S3WA 3INVA 3NXVA 3EEKA 3NXOA 1DRAA 2W9GA 1S3YA 2QK8A 1JOMA 4XT4A 3ZPGA 2W3AA 2W9HA 4KEBA 4EIZA 1RA2A 3TQBA 4M6JA 2HM9A 3N0HA 3SAIA 3E0BA 4X5FA 3QLSA 1DDSA 5HF2X 2CIGA 3KFYA 1J3IA 4M2XA 4PTHA 4P3QA 5HPBA 4XECX 3RO9A 2JYBA 3NZCX 4LAGX 4KBNA 1DRHA 1RH3A 1DYRA 2ANQA 3NZBX 1LY4A 1DRBA 1U72A 3F0BX 3OCHA 3GHWA 3GHCA 3K74A 3FY9X 3JWMA 3JWCA 4IXFX 5U27A 3QLYA 1RF7A 4EILA 3UM6A 5HQYA 5ECXA 4ECKA 2C2SA 3CL9A 3FYWX 4KY8A 1HFRA 3FYVX 1VJ3A 5HVBA 4ELEA 4I1NA 3QLZA 2W3BA 1LY3A 4QLFA 1OHKA 4HOEA 2DRCA 1DHJA 2KGKA 1DF7A 4NX6A 4EJ1A 4KNEA 2D5NA 3FRBX 4QLEA 3DATA 5DFRA 4PSYA 4KFJA 5ECCA 4Q6AA 3M09A 3SRWX 3I3RA 3FY8X 4H97A 4PSSA 4I13A 5HT5A 3NRRA 4PTJA 3SA1A 4RGCA 4P68A 4FGHA 3QYLA 2GD9A 3CSEA 5HT4A 4X5IA 3TQ8A 3DL6A 4X5JA 1DR2A 3QFXA 4XT6A 2INQA 4XE6X 7DFRA 4P3RA 3SA2A 1DHIA 4KM0A 3NTZA 3FQ0A 2ZZAA 3FQOA 1DDRA 1D1GA 4ELFA 1S3UA 1CD2A 2LF1A 3K47A 3EEJA 4OSGA 4IXGX 1JUVA 1KLKA 3I8AX 2ITHA 3RG9A 5HF0X 1J3JA 4HOFA 1DR5A 4XT5A 1KMVA 4HA7A 3QGTA 3FRFX 1RX3A 4KL9A 3NXXA 3FL9A 4DPHA 1YHOA 3K2HA 3FRAX 1M79A 1RX6A 4Q0DA 4GH8A 1RB2A 4QI9A 4X5GA 1RD7A 1VDRA 4FGGA 1LUDA 3IA5A 3F0QX 2BLBA 4IXED 5U26A 1BOZA 1AO8A 4HA9A 3SRSX 2W9SA 3M08A 1SEJA 4DDRA 2HQPA 1DG5A 2W3VA 5JG0X 2P4GA 4FHBA 1RX2A 2AZNA 4DFRA 4CD2A 3FQFA 1DR3A 4KJLA 3VCOA 3DFRA 3FRDX 3IRNA 1DG7A 1RX5A 3DRCA 3JVXA 3QLWA 1HFPA 3NXRA 1DYIA 3F0SX 4P66A 4KD7A 1E26A 1RX1A 3DAUA 3F0UX 4TU5X 3KJRA 2FZJA 2OIPA 4KAKA 1HFQA 3EEMA 1RA3A 4PDJA 4Q0EA 2OBCA 3FQVA 1IA3A 4KY4A 3QG2A 3CD2A 4M6KA 1DR1A 4NX7A 5HSRA 1BZFA 1PDBA 4QHVA 5HI6A 1AI9A 2ANOA 3GI2A 3DGAA 1U70A 1DIUA 3FS6A 3LG4A 2BLCA 3IROA 1RA8A 1MVSA 5JA3A 3IX9A 3JWFA 1RX7A 4LEKX 4LAEX 3NU0A 1RA1A 1DR4A 4G3MA 3SRRX 1RX9A 3TD8A 4ELGA 3JSUA 3DG8A 3GHVA 4X5HA 4DPDA 1JOLA 1DR6A 4HOGA 2B3ZA 3EIGA 3JW3A 2G6VA 3IRMA 1ZDRA 4DP3A 3JWKA 2BL9A 5HQZA 4G95A 3F91A 3SQYX 1DYJA 1IA4A 1TDRA 1PD9A 1RB3A 4M7VA 4PSTA 5HSUA 4M7UA 3UM8A 1KMSA 3F0VX 3HBBA 3D80A 3S3VA 4EIGA 5CCCA 3HJ3A 3F8ZA 3FL8A 3QLRA 4KJKA 4QJCA 1QZFA 5CC9A 4KM2A 3SRUX 1U71A 2CD2A 3SGYA 1RX4A 3F8YA 5HVEA 4XT8A 1OHJA 3KY8A 3NZ6X 1DG8A 2DHFA 6DFRA 1DRFA 2C2TA 4XT7A 3F0XX 3KJSA
chains in the Genus database with same CATH topology
3SR5X 3FREX 4KYAA 3CLBA 1DISA 3NZAX 3TQ9A 4QLGA 1AOEA 3QL3A 3NXTA 4XRBA 4OR7A 2BLAA 4H98A 4G8ZX 1DLRA 3JTWA 5EAJA 1IA1A 2W9TA 2HXVA 3R33A 1J3KA 4KJJA 3TQAA 3IA4A 1RX8A 1DHFA 4ELHA 4QJZD 2O7PA 3ZPCA 1RE7A 3S9UA 4KLXA 1MVTA 2H2QA 8DFRA 1DYHA 3FQCA 4H95A 3NXYA 2FZHA 3KGYA 3EELA 2L28A 1S3VA 2W3WA 1PD8A 1DREA 1DLSA 3QL0A 5E8QA 3NZ9X 3EX8A 5DXVA 3OAFA 2FZIA 3S7AA 5FDAA 3FQZA 3SRQX 3QLXA 4ELBA 3L3RA 2XW7A 5HUIA 3GYFA 4Q67A 3Q1HA 3UM5A 1DAJA 1RC4A 3DL5A 4M6LA 4H96A 1RG7A 2D0KA 1DR7A 1IA2A 3QYOA 2W3MA 3NZDA 1CZ3A 1M78A 3ROAA 1RA9A 4LAHX 3D84X 3K45A 1M7AA 3JW5A 3SH2A 1S3WA 3INVA 3NXVA 3EEKA 3NXOA 1DRAA 2W9GA 1S3YA 2QK8A 1JOMA 4XT4A 3ZPGA 2W3AA 2W9HA 4KEBA 4EIZA 1RA2A 3TQBA 4M6JA 2HM9A 3N0HA 3SAIA 3E0BA 4X5FA 3QLSA 1DDSA 5HF2X 2CIGA 3KFYA 1J3IA 4M2XA 4PTHA 4P3QA 5HPBA 4XECX 3RO9A 2JYBA 3NZCX 4LAGX 4KBNA 1DRHA 1RH3A 1DYRA 2ANQA 3NZBX 1LY4A 1DRBA 1U72A 3F0BX 3OCHA 3GHWA 3GHCA 3K74A 3FY9X 3JWMA 3JWCA 4IXFX 5U27A 3QLYA 1RF7A 4EILA 3UM6A 5HQYA 5ECXA 4ECKA 2C2SA 3CL9A 3FYWX 4KY8A 1HFRA 3FYVX 1VJ3A 5HVBA 4ELEA 4I1NA 3QLZA 2W3BA 1LY3A 4QLFA 1OHKA 4HOEA 2DRCA 1DHJA 2KGKA 1DF7A 4NX6A 4EJ1A 4KNEA 2D5NA 3FRBX 4QLEA 3DATA 5DFRA 4PSYA 4KFJA 5ECCA 4Q6AA 3M09A 3SRWX 3I3RA 3FY8X 4H97A 4PSSA 4I13A 5HT5A 3NRRA 4PTJA 3SA1A 4RGCA 4P68A 4FGHA 3QYLA 2GD9A 3CSEA 5HT4A 4X5IA 3TQ8A 3DL6A 4X5JA 1DR2A 3QFXA 4XT6A 2INQA 4XE6X 7DFRA 4P3RA 3SA2A 1DHIA 4KM0A 3NTZA 3FQ0A 2ZZAA 3FQOA 1DDRA 1D1GA 4ELFA 1S3UA 1CD2A 2LF1A 3K47A 3EEJA 4OSGA 4IXGX 1JUVA 1KLKA 3I8AX 2ITHA 3RG9A 5HF0X 1J3JA 4HOFA 1DR5A 4XT5A 1KMVA 4HA7A 3QGTA 3FRFX 1RX3A 4KL9A 3NXXA 3FL9A 4DPHA 1YHOA 3K2HA 3FRAX 1M79A 1RX6A 4Q0DA 4GH8A 1RB2A 4QI9A 4X5GA 1RD7A 1VDRA 4FGGA 1LUDA 3IA5A 3F0QX 2BLBA 4IXED 5U26A 1BOZA 1AO8A 4HA9A 3SRSX 2W9SA 3M08A 1SEJA 4DDRA 2HQPA 1DG5A 2W3VA 5JG0X 2P4GA 4FHBA 1RX2A 2AZNA 4DFRA 4CD2A 3FQFA 1DR3A 4KJLA 3VCOA 3DFRA 3FRDX 3IRNA 1DG7A 1RX5A 3DRCA 3JVXA 3QLWA 1HFPA 3NXRA 1DYIA 3F0SX 4P66A 4KD7A 1E26A 1RX1A 3DAUA 3F0UX 4TU5X 3KJRA 2FZJA 2OIPA 4KAKA 1HFQA 3EEMA 1RA3A 4PDJA 4Q0EA 2OBCA 3FQVA 1IA3A 4KY4A 3QG2A 3CD2A 4M6KA 1DR1A 4NX7A 5HSRA 1BZFA 1PDBA 4QHVA 5HI6A 1AI9A 2ANOA 3GI2A 3DGAA 1U70A 1DIUA 3FS6A 3LG4A 2BLCA 3IROA 1RA8A 1MVSA 5JA3A 3IX9A 3JWFA 1RX7A 4LEKX 4LAEX 3NU0A 1RA1A 1DR4A 4G3MA 3SRRX 1RX9A 3TD8A 4ELGA 3JSUA 3DG8A 3GHVA 4X5HA 4DPDA 1JOLA 1DR6A 4HOGA 2B3ZA 3EIGA 3JW3A 2G6VA 3IRMA 1ZDRA 4DP3A 3JWKA 2BL9A 5HQZA 4G95A 3F91A 3SQYX 1DYJA 1IA4A 1TDRA 1PD9A 1RB3A 4M7VA 4PSTA 5HSUA 4M7UA 3UM8A 1KMSA 3F0VX 3HBBA 3D80A 3S3VA 4EIGA 5CCCA 3HJ3A 3F8ZA 3FL8A 3QLRA 4KJKA 4QJCA 1QZFA 5CC9A 4KM2A 3SRUX 1U71A 2CD2A 3SGYA 1RX4A 3F8YA 5HVEA 4XT8A 1OHJA 3KY8A 3NZ6X 1DG8A 2DHFA 6DFRA 1DRFA 2C2TA 4XT7A 3F0XX 3KJSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SR5 X;  3FRE X;  4KYA A;  3CLB A;  1DIS A;  3NZA X;  3TQ9 A;  4QLG A;  1AOE A;  3QL3 A;  3NXT A;  4XRB A;  4OR7 A;  2BLA A;  4H98 A;  4G8Z X;  1DLR A;  3JTW A;  5EAJ A;  1IA1 A;  2W9T A;  2HXV A;  3R33 A;  1J3K A;  4KJJ A;  3TQA A;  3IA4 A;  1RX8 A;  1DHF A;  4ELH A;  4QJZ D;  2O7P A;  3ZPC A;  1RE7 A;  3S9U A;  4KLX A;  1MVT A;  2H2Q A;  8DFR A;  1DYH A;  3FQC A;  4H95 A;  3NXY A;  2FZH A;  3KGY A;  3EEL A;  2L28 A;  1S3V A;  2W3W A;  1PD8 A;  1DRE A;  1DLS A;  3QL0 A;  5E8Q A;  3NZ9 X;  3EX8 A;  5DXV A;  3OAF A;  2FZI A;  3S7A A;  5FDA A;  3FQZ A;  3SRQ X;  3QLX A;  4ELB A;  3L3R A;  2XW7 A;  5HUI A;  3GYF A;  4Q67 A;  3Q1H A;  3UM5 A;  1DAJ A;  1RC4 A;  3DL5 A;  4M6L A;  4H96 A;  1RG7 A;  2D0K A;  1DR7 A;  1IA2 A;  3QYO A;  2W3M A;  3NZD A;  1CZ3 A;  1M78 A;  3ROA A;  1RA9 A;  4LAH X;  3D84 X;  3K45 A;  1M7A A;  3JW5 A;  3SH2 A;  1S3W A;  3INV A;  3NXV A;  3EEK A;  3NXO A;  1DRA A;  2W9G A;  1S3Y A;  2QK8 A;  1JOM A;  4XT4 A;  3ZPG A;  2W3A A;  2W9H A;  4KEB A;  4EIZ A;  1RA2 A;  3TQB A;  4M6J A;  2HM9 A;  3N0H A;  3SAI A;  3E0B A;  4X5F A;  3QLS A;  1DDS A;  5HF2 X;  2CIG A;  3KFY A;  1J3I A;  4M2X A;  4PTH A;  4P3Q A;  5HPB A;  4XEC X;  3RO9 A;  2JYB A;  3NZC X;  4LAG X;  4KBN A;  1DRH A;  1RH3 A;  1DYR A;  2ANQ A;  3NZB X;  1LY4 A;  1DRB A;  1U72 A;  3F0B X;  3OCH A;  3GHW A;  3GHC A;  3K74 A;  3FY9 X;  3JWM A;  3JWC A;  4IXF X;  5U27 A;  3QLY A;  1RF7 A;  4EIL A;  3UM6 A;  5HQY A;  5ECX A;  4ECK A;  2C2S A;  3CL9 A;  3FYW X;  4KY8 A;  1HFR A;  3FYV X;  1VJ3 A;  5HVB A;  4ELE A;  4I1N A;  3QLZ A;  2W3B A;  1LY3 A;  4QLF A;  1OHK A;  4HOE A;  2DRC A;  1DHJ A;  2KGK A;  1DF7 A;  4NX6 A;  4EJ1 A;  4KNE A;  2D5N A;  3FRB X;  4QLE A;  3DAT A;  5DFR A;  4PSY A;  4KFJ A;  5ECC A;  4Q6A A;  3M09 A;  3SRW X;  3I3R A;  3FY8 X;  4H97 A;  4PSS A;  4I13 A;  5HT5 A;  3NRR A;  4PTJ A;  3SA1 A;  4RGC A;  4P68 A;  4FGH A;  3QYL A;  2GD9 A;  3CSE A;  5HT4 A;  4X5I A;  3TQ8 A;  3DL6 A;  4X5J A;  1DR2 A;  3QFX A;  4XT6 A;  2INQ A;  4XE6 X;  7DFR A;  4P3R A;  3SA2 A;  1DHI A;  4KM0 A;  3NTZ A;  3FQ0 A;  2ZZA A;  3FQO A;  1DDR A;  1D1G A;  4ELF A;  1S3U A;  1CD2 A;  2LF1 A;  3K47 A;  3EEJ A;  4OSG A;  4IXG X;  1JUV A;  1KLK A;  3I8A X;  2ITH A;  3RG9 A;  5HF0 X;  1J3J A;  4HOF A;  1DR5 A;  4XT5 A;  1KMV A;  4HA7 A;  3QGT A;  3FRF X;  1RX3 A;  4KL9 A;  3NXX A;  3FL9 A;  4DPH A;  1YHO A;  3K2H A;  3FRA X;  1M79 A;  1RX6 A;  4Q0D A;  4GH8 A;  1RB2 A;  4QI9 A;  4X5G A;  1RD7 A;  1VDR A;  4FGG A;  1LUD A;  3IA5 A;  3F0Q X;  2BLB A;  4IXE D;  5U26 A;  1BOZ A;  1AO8 A;  4HA9 A;  3SRS X;  2W9S A;  3M08 A;  1SEJ A;  4DDR A;  2HQP A;  1DG5 A;  2W3V A;  5JG0 X;  2P4G A;  4FHB A;  1RX2 A;  2AZN A;  4DFR A;  4CD2 A;  3FQF A;  1DR3 A;  4KJL A;  3VCO A;  3DFR A;  3FRD X;  3IRN A;  1DG7 A;  1RX5 A;  3DRC A;  3JVX A;  3QLW A;  1HFP A;  3NXR A;  1DYI A;  3F0S X;  4P66 A;  4KD7 A;  1E26 A;  1RX1 A;  3DAU A;  3F0U X;  4TU5 X;  3KJR A;  2FZJ A;  2OIP A;  4KAK A;  1HFQ A;  3EEM A;  1RA3 A;  4PDJ A;  4Q0E A;  2OBC A;  3FQV A;  1IA3 A;  4KY4 A;  3QG2 A;  3CD2 A;  4M6K A;  1DR1 A;  4NX7 A;  5HSR A;  1BZF A;  1PDB A;  4QHV A;  5HI6 A;  1AI9 A;  2ANO A;  3GI2 A;  3DGA A;  1U70 A;  1DIU A;  3FS6 A;  3LG4 A;  2BLC A;  3IRO A;  1RA8 A;  1MVS A;  5JA3 A;  3IX9 A;  3JWF A;  1RX7 A;  4LEK X;  4LAE X;  3NU0 A;  1RA1 A;  1DR4 A;  4G3M A;  3SRR X;  1RX9 A;  3TD8 A;  4ELG A;  3JSU A;  3DG8 A;  3GHV A;  4X5H A;  4DPD A;  1JOL A;  1DR6 A;  4HOG A;  2B3Z A;  3EIG A;  3JW3 A;  2G6V A;  3IRM A;  1ZDR A;  4DP3 A;  3JWK A;  2BL9 A;  5HQZ A;  4G95 A;  3F91 A;  3SQY X;  1DYJ A;  1IA4 A;  1TDR A;  1PD9 A;  1RB3 A;  4M7V A;  4PST A;  5HSU A;  4M7U A;  3UM8 A;  1KMS A;  3F0V X;  3HBB A;  3D80 A;  3S3V A;  4EIG A;  5CCC A;  3HJ3 A;  3F8Z A;  3FL8 A;  3QLR A;  4KJK A;  4QJC A;  1QZF A;  5CC9 A;  4KM2 A;  3SRU X;  1U71 A;  2CD2 A;  3SGY A;  1RX4 A;  3F8Y A;  5HVE A;  4XT8 A;  1OHJ A;  3KY8 A;  3NZ6 X;  1DG8 A;  2DHF A;  6DFR A;  1DRF A;  2C2T A;  4XT7 A;  3F0X X;  3KJS A; 
#chains in the Genus database with same CATH topology
 3SR5 X;  3FRE X;  4KYA A;  3CLB A;  1DIS A;  3NZA X;  3TQ9 A;  4QLG A;  1AOE A;  3QL3 A;  3NXT A;  4XRB A;  4OR7 A;  2BLA A;  4H98 A;  4G8Z X;  1DLR A;  3JTW A;  5EAJ A;  1IA1 A;  2W9T A;  2HXV A;  3R33 A;  1J3K A;  4KJJ A;  3TQA A;  3IA4 A;  1RX8 A;  1DHF A;  4ELH A;  4QJZ D;  2O7P A;  3ZPC A;  1RE7 A;  3S9U A;  4KLX A;  1MVT A;  2H2Q A;  8DFR A;  1DYH A;  3FQC A;  4H95 A;  3NXY A;  2FZH A;  3KGY A;  3EEL A;  2L28 A;  1S3V A;  2W3W A;  1PD8 A;  1DRE A;  1DLS A;  3QL0 A;  5E8Q A;  3NZ9 X;  3EX8 A;  5DXV A;  3OAF A;  2FZI A;  3S7A A;  5FDA A;  3FQZ A;  3SRQ X;  3QLX A;  4ELB A;  3L3R A;  2XW7 A;  5HUI A;  3GYF A;  4Q67 A;  3Q1H A;  3UM5 A;  1DAJ A;  1RC4 A;  3DL5 A;  4M6L A;  4H96 A;  1RG7 A;  2D0K A;  1DR7 A;  1IA2 A;  3QYO A;  2W3M A;  3NZD A;  1CZ3 A;  1M78 A;  3ROA A;  1RA9 A;  4LAH X;  3D84 X;  3K45 A;  1M7A A;  3JW5 A;  3SH2 A;  1S3W A;  3INV A;  3NXV A;  3EEK A;  3NXO A;  1DRA A;  2W9G A;  1S3Y A;  2QK8 A;  1JOM A;  4XT4 A;  3ZPG A;  2W3A A;  2W9H A;  4KEB A;  4EIZ A;  1RA2 A;  3TQB A;  4M6J A;  2HM9 A;  3N0H A;  3SAI A;  3E0B A;  4X5F A;  3QLS A;  1DDS A;  5HF2 X;  2CIG A;  3KFY A;  1J3I A;  4M2X A;  4PTH A;  4P3Q A;  5HPB A;  4XEC X;  3RO9 A;  2JYB A;  3NZC X;  4LAG X;  4KBN A;  1DRH A;  1RH3 A;  1DYR A;  2ANQ A;  3NZB X;  1LY4 A;  1DRB A;  1U72 A;  3F0B X;  3OCH A;  3GHW A;  3GHC A;  3K74 A;  3FY9 X;  3JWM A;  3JWC A;  4IXF X;  5U27 A;  3QLY A;  1RF7 A;  4EIL A;  3UM6 A;  5HQY A;  5ECX A;  4ECK A;  2C2S A;  3CL9 A;  3FYW X;  4KY8 A;  1HFR A;  3FYV X;  1VJ3 A;  5HVB A;  4ELE A;  4I1N A;  3QLZ A;  2W3B A;  1LY3 A;  4QLF A;  1OHK A;  4HOE A;  2DRC A;  1DHJ A;  2KGK A;  1DF7 A;  4NX6 A;  4EJ1 A;  4KNE A;  2D5N A;  3FRB X;  4QLE A;  3DAT A;  5DFR A;  4PSY A;  4KFJ A;  5ECC A;  4Q6A A;  3M09 A;  3SRW X;  3I3R A;  3FY8 X;  4H97 A;  4PSS A;  4I13 A;  5HT5 A;  3NRR A;  4PTJ A;  3SA1 A;  4RGC A;  4P68 A;  4FGH A;  3QYL A;  2GD9 A;  3CSE A;  5HT4 A;  4X5I A;  3TQ8 A;  3DL6 A;  4X5J A;  1DR2 A;  3QFX A;  4XT6 A;  2INQ A;  4XE6 X;  7DFR A;  4P3R A;  3SA2 A;  1DHI A;  4KM0 A;  3NTZ A;  3FQ0 A;  2ZZA A;  3FQO A;  1DDR A;  1D1G A;  4ELF A;  1S3U A;  1CD2 A;  2LF1 A;  3K47 A;  3EEJ A;  4OSG A;  4IXG X;  1JUV A;  1KLK A;  3I8A X;  2ITH A;  3RG9 A;  5HF0 X;  1J3J A;  4HOF A;  1DR5 A;  4XT5 A;  1KMV A;  4HA7 A;  3QGT A;  3FRF X;  1RX3 A;  4KL9 A;  3NXX A;  3FL9 A;  4DPH A;  1YHO A;  3K2H A;  3FRA X;  1M79 A;  1RX6 A;  4Q0D A;  4GH8 A;  1RB2 A;  4QI9 A;  4X5G A;  1RD7 A;  1VDR A;  4FGG A;  1LUD A;  3IA5 A;  3F0Q X;  2BLB A;  4IXE D;  5U26 A;  1BOZ A;  1AO8 A;  4HA9 A;  3SRS X;  2W9S A;  3M08 A;  1SEJ A;  4DDR A;  2HQP A;  1DG5 A;  2W3V A;  5JG0 X;  2P4G A;  4FHB A;  1RX2 A;  2AZN A;  4DFR A;  4CD2 A;  3FQF A;  1DR3 A;  4KJL A;  3VCO A;  3DFR A;  3FRD X;  3IRN A;  1DG7 A;  1RX5 A;  3DRC A;  3JVX A;  3QLW A;  1HFP A;  3NXR A;  1DYI A;  3F0S X;  4P66 A;  4KD7 A;  1E26 A;  1RX1 A;  3DAU A;  3F0U X;  4TU5 X;  3KJR A;  2FZJ A;  2OIP A;  4KAK A;  1HFQ A;  3EEM A;  1RA3 A;  4PDJ A;  4Q0E A;  2OBC A;  3FQV A;  1IA3 A;  4KY4 A;  3QG2 A;  3CD2 A;  4M6K A;  1DR1 A;  4NX7 A;  5HSR A;  1BZF A;  1PDB A;  4QHV A;  5HI6 A;  1AI9 A;  2ANO A;  3GI2 A;  3DGA A;  1U70 A;  1DIU A;  3FS6 A;  3LG4 A;  2BLC A;  3IRO A;  1RA8 A;  1MVS A;  5JA3 A;  3IX9 A;  3JWF A;  1RX7 A;  4LEK X;  4LAE X;  3NU0 A;  1RA1 A;  1DR4 A;  4G3M A;  3SRR X;  1RX9 A;  3TD8 A;  4ELG A;  3JSU A;  3DG8 A;  3GHV A;  4X5H A;  4DPD A;  1JOL A;  1DR6 A;  4HOG A;  2B3Z A;  3EIG A;  3JW3 A;  2G6V A;  3IRM A;  1ZDR A;  4DP3 A;  3JWK A;  2BL9 A;  5HQZ A;  4G95 A;  3F91 A;  3SQY X;  1DYJ A;  1IA4 A;  1TDR A;  1PD9 A;  1RB3 A;  4M7V A;  4PST A;  5HSU A;  4M7U A;  3UM8 A;  1KMS A;  3F0V X;  3HBB A;  3D80 A;  3S3V A;  4EIG A;  5CCC A;  3HJ3 A;  3F8Z A;  3FL8 A;  3QLR A;  4KJK A;  4QJC A;  1QZF A;  5CC9 A;  4KM2 A;  3SRU X;  1U71 A;  2CD2 A;  3SGY A;  1RX4 A;  3F8Y A;  5HVE A;  4XT8 A;  1OHJ A;  3KY8 A;  3NZ6 X;  1DG8 A;  2DHF A;  6DFR A;  1DRF A;  2C2T A;  4XT7 A;  3F0X X;  3KJS A; 
#chains in the Genus database with same CATH homology
 3SR5 X;  3FRE X;  4KYA A;  3CLB A;  1DIS A;  3NZA X;  3TQ9 A;  4QLG A;  1AOE A;  3QL3 A;  3NXT A;  4XRB A;  4OR7 A;  2BLA A;  4H98 A;  4G8Z X;  1DLR A;  3JTW A;  5EAJ A;  1IA1 A;  2W9T A;  2HXV A;  3R33 A;  1J3K A;  4KJJ A;  3TQA A;  3IA4 A;  1RX8 A;  1DHF A;  4ELH A;  4QJZ D;  2O7P A;  3ZPC A;  1RE7 A;  3S9U A;  4KLX A;  1MVT A;  2H2Q A;  8DFR A;  1DYH A;  3FQC A;  4H95 A;  3NXY A;  2FZH A;  3KGY A;  3EEL A;  2L28 A;  1S3V A;  2W3W A;  1PD8 A;  1DRE A;  1DLS A;  3QL0 A;  5E8Q A;  3NZ9 X;  3EX8 A;  5DXV A;  3OAF A;  2FZI A;  3S7A A;  5FDA A;  3FQZ A;  3SRQ X;  3QLX A;  4ELB A;  3L3R A;  2XW7 A;  5HUI A;  3GYF A;  4Q67 A;  3Q1H A;  3UM5 A;  1DAJ A;  1RC4 A;  3DL5 A;  4M6L A;  4H96 A;  1RG7 A;  2D0K A;  1DR7 A;  1IA2 A;  3QYO A;  2W3M A;  3NZD A;  1CZ3 A;  1M78 A;  3ROA A;  1RA9 A;  4LAH X;  3D84 X;  3K45 A;  1M7A A;  3JW5 A;  3SH2 A;  1S3W A;  3INV A;  3NXV A;  3EEK A;  3NXO A;  1DRA A;  2W9G A;  1S3Y A;  2QK8 A;  1JOM A;  4XT4 A;  3ZPG A;  2W3A A;  2W9H A;  4KEB A;  4EIZ A;  1RA2 A;  3TQB A;  4M6J A;  2HM9 A;  3N0H A;  3SAI A;  3E0B A;  4X5F A;  3QLS A;  1DDS A;  5HF2 X;  2CIG A;  3KFY A;  1J3I A;  4M2X A;  4PTH A;  4P3Q A;  5HPB A;  4XEC X;  3RO9 A;  2JYB A;  3NZC X;  4LAG X;  4KBN A;  1DRH A;  1RH3 A;  1DYR A;  2ANQ A;  3NZB X;  1LY4 A;  1DRB A;  1U72 A;  3F0B X;  3OCH A;  3GHW A;  3GHC A;  3K74 A;  3FY9 X;  3JWM A;  3JWC A;  4IXF X;  5U27 A;  3QLY A;  1RF7 A;  4EIL A;  3UM6 A;  5HQY A;  5ECX A;  4ECK A;  2C2S A;  3CL9 A;  3FYW X;  4KY8 A;  1HFR A;  3FYV X;  1VJ3 A;  5HVB A;  4ELE A;  4I1N A;  3QLZ A;  2W3B A;  1LY3 A;  4QLF A;  1OHK A;  4HOE A;  2DRC A;  1DHJ A;  2KGK A;  1DF7 A;  4NX6 A;  4EJ1 A;  4KNE A;  2D5N A;  3FRB X;  4QLE A;  3DAT A;  5DFR A;  4PSY A;  4KFJ A;  5ECC A;  4Q6A A;  3M09 A;  3SRW X;  3I3R A;  3FY8 X;  4H97 A;  4PSS A;  4I13 A;  5HT5 A;  3NRR A;  4PTJ A;  3SA1 A;  4RGC A;  4P68 A;  4FGH A;  3QYL A;  2GD9 A;  3CSE A;  5HT4 A;  4X5I A;  3TQ8 A;  3DL6 A;  4X5J A;  1DR2 A;  3QFX A;  4XT6 A;  2INQ A;  4XE6 X;  7DFR A;  4P3R A;  3SA2 A;  1DHI A;  4KM0 A;  3NTZ A;  3FQ0 A;  2ZZA A;  3FQO A;  1DDR A;  1D1G A;  4ELF A;  1S3U A;  1CD2 A;  2LF1 A;  3K47 A;  3EEJ A;  4OSG A;  4IXG X;  1JUV A;  1KLK A;  3I8A X;  2ITH A;  3RG9 A;  5HF0 X;  1J3J A;  4HOF A;  1DR5 A;  4XT5 A;  1KMV A;  4HA7 A;  3QGT A;  3FRF X;  1RX3 A;  4KL9 A;  3NXX A;  3FL9 A;  4DPH A;  1YHO A;  3K2H A;  3FRA X;  1M79 A;  1RX6 A;  4Q0D A;  4GH8 A;  1RB2 A;  4QI9 A;  4X5G A;  1RD7 A;  1VDR A;  4FGG A;  1LUD A;  3IA5 A;  3F0Q X;  2BLB A;  4IXE D;  5U26 A;  1BOZ A;  1AO8 A;  4HA9 A;  3SRS X;  2W9S A;  3M08 A;  1SEJ A;  4DDR A;  2HQP A;  1DG5 A;  2W3V A;  5JG0 X;  2P4G A;  4FHB A;  1RX2 A;  2AZN A;  4DFR A;  4CD2 A;  3FQF A;  1DR3 A;  4KJL A;  3VCO A;  3DFR A;  3FRD X;  3IRN A;  1DG7 A;  1RX5 A;  3DRC A;  3JVX A;  3QLW A;  1HFP A;  3NXR A;  1DYI A;  3F0S X;  4P66 A;  4KD7 A;  1E26 A;  1RX1 A;  3DAU A;  3F0U X;  4TU5 X;  3KJR A;  2FZJ A;  2OIP A;  4KAK A;  1HFQ A;  3EEM A;  1RA3 A;  4PDJ A;  4Q0E A;  2OBC A;  3FQV A;  1IA3 A;  4KY4 A;  3QG2 A;  3CD2 A;  4M6K A;  1DR1 A;  4NX7 A;  5HSR A;  1BZF A;  1PDB A;  4QHV A;  5HI6 A;  1AI9 A;  2ANO A;  3GI2 A;  3DGA A;  1U70 A;  1DIU A;  3FS6 A;  3LG4 A;  2BLC A;  3IRO A;  1RA8 A;  1MVS A;  5JA3 A;  3IX9 A;  3JWF A;  1RX7 A;  4LEK X;  4LAE X;  3NU0 A;  1RA1 A;  1DR4 A;  4G3M A;  3SRR X;  1RX9 A;  3TD8 A;  4ELG A;  3JSU A;  3DG8 A;  3GHV A;  4X5H A;  4DPD A;  1JOL A;  1DR6 A;  4HOG A;  2B3Z A;  3EIG A;  3JW3 A;  2G6V A;  3IRM A;  1ZDR A;  4DP3 A;  3JWK A;  2BL9 A;  5HQZ A;  4G95 A;  3F91 A;  3SQY X;  1DYJ A;  1IA4 A;  1TDR A;  1PD9 A;  1RB3 A;  4M7V A;  4PST A;  5HSU A;  4M7U A;  3UM8 A;  1KMS A;  3F0V X;  3HBB A;  3D80 A;  3S3V A;  4EIG A;  5CCC A;  3HJ3 A;  3F8Z A;  3FL8 A;  3QLR A;  4KJK A;  4QJC A;  1QZF A;  5CC9 A;  4KM2 A;  3SRU X;  1U71 A;  2CD2 A;  3SGY A;  1RX4 A;  3F8Y A;  5HVE A;  4XT8 A;  1OHJ A;  3KY8 A;  3NZ6 X;  1DG8 A;  2DHF A;  6DFR A;  1DRF A;  2C2T A;  4XT7 A;  3F0X X;  3KJS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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