1S3UA

Structure determination of tetrahydroquinazoline antifolates in complex with human and pneumocystis carinii dihydrofolate reductase: correlations of enzyme selectivity and stereochemistry
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 52
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2004-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1s3uA00
1RX4A 1RG7A 1VJ3A 3F0VX 2CIGA 4QJZD 4KJLA 3ZPGA 4DDRA 1J3IA 3KFYA 3NZCX 3QL3A 3SQYX 3FYWX 4PDJA 3GHCA 1RA8A 3QLYA 2BLCA 5JG0X 2QK8A 3SRQX 1DR2A 3LG4A 3JW3A 4G3MA 1RD7A 5ECXA 4EJ1A 2GD9A 6DFRA 3M08A 3EEJA 3OCHA 3FS6A 1RX5A 4Q0EA 1DR3A 3F0XX 1DAJA 1RA2A 4M2XA 3DL5A 4OSGA 1IA3A 3S3VA 1DISA 4KD7A 3UM8A 4H96A 3ZPCA 1RB3A 3SRUX 1DYRA 4X5FA 4XT5A 3IRMA 5HVBA 3EELA 3SH2A 1LY4A 3CL9A 2H2QA 1DRFA 3QLXA 4Q67A 3KGYA 3TQ9A 3NZ9X 4ELBA 4M7UA 1CD2A 2FZHA 4DFRA 4P3QA 4IXED 4CD2A 3JVXA 1DDRA 4HA9A 3F0QX 1DR1A 4PSTA 3UM6A 3NZDA 5ECCA 3FQZA 3SRWX 4RGCA 5EAJA 1DYIA 3JTWA 3RO9A 1DYHA 4KEBA 4FHBA 1RF7A 2B3ZA 1MVSA 3FRAX 2HM9A 1JUVA 3GHVA 5DXVA 3FQFA 3HJ3A 1LUDA 1D1GA 3K47A 3DG8A 1DHIA 5HSUA 2D5NA 3FREX 3K45A 3DRCA 2KGKA 2L28A 1RX7A 4M6JA 2BL9A 3S9UA 3EEMA 1BOZA 4ECKA 4X5IA 4X5HA 4P3RA 1AI9A 4QLFA 1U70A 1RX8A 1RX6A 3QFXA 1VDRA 3FRFX 1DR7A 3N0HA 3FQ0A 5HT4A 1HFQA 4G8ZX 4HOEA 4QJCA 1AOEA 3JW5A 2W3MA 3DATA 4KNEA 4ELFA 1LY3A 2XW7A 2HQPA 2LF1A 3NXTA 4HOFA 1OHKA 3DGAA 3RG9A 3CSEA 3EIGA 5HI6A 1DG8A 1DHJA 3UM5A 4FGGA 4EILA 5HQZA 5CC9A 2W3BA 1HFPA 1JOLA 3SAIA 5FDAA 4KL9A 4KFJA 3NZAX 4M7VA 1DG5A 3D84X 2AZNA 3FRBX 3NZ6X 3Q1HA 3QLZA 3FQVA 3I8AX 3FQCA 5HQYA 3EX8A 4EIZA 3SGYA 4I13A 4XT8A 4H97A 4X5GA 4LEKX 3QL0A 3L3RA 1KLKA 1U71A 2INQA 5U26A 1IA4A 1U72A 1TDRA 3JWFA 3D80A 2W9TA 3NZBX 4KM2A 2W3VA 2W3AA 1PDBA 2BLAA 2JYBA 1J3JA 2HXVA 3TQBA 4M6KA 5DFRA 1RA1A 3INVA 4HA7A 1RX3A 3K2HA 2D0KA 2O7PA 4Q6AA 4QHVA 1RB2A 3QLWA 4QLEA 5HPBA 3KJRA 1S3YA 3F0SX 1S3WA 2BLBA 3NXOA 1RC4A 2FZIA 3I3RA 4DP3A 3NXYA 3NTZA 3SRRX 1RX1A 3SA1A 4Q0DA 4XECX 1QZFA 2FZJA 3QLRA 3QYOA 3IA4A 1RE7A 3QGTA 1DRBA 4PTHA 2P4GA 4TU5X 4KY8A 1S3VA 3S7AA 5HF2X 1DF7A 1KMSA 4NX6A 3DL6A 1RX2A 3QG2A 5E8QA 3FL8A 1DLSA 2C2TA 4DPDA 3JWMA 4PTJA 3CD2A 3ROAA 4ELHA 1MVTA 5CCCA 3JWKA 3F8YA 4KYAA 4HOGA 5HT5A 1M7AA 3EEKA 4NX7A 3JWCA 1DG7A 4KJJA 1IA1A 1OHJA 3SA2A 1AO8A 3F91A 4LAHX 4XT6A 2OIPA 3FQOA 4KM0A 1E26A 4I1NA 1RA3A 1S3UA 4OR7A 3IA5A 4LAEX 2ANQA 1DR6A 3SR5X 3NXXA 3QLSA 1DYJA 1RX9A 4QI9A 1CZ3A 3GHWA 4LAGX 1RH3A 3KJSA 4IXGX 4M6LA 1SEJA 1J3KA 3TQ8A 3FRDX 2DRCA 1IA2A 2ITHA 1BZFA 1PD9A 2OBCA 1DR5A 3JSUA 4KLXA 4PSYA 1HFRA 4XT4A 1YHOA 3FY8X 5HF0X 3F0UX 4FGHA 3FYVX 2W9HA 2W9GA 5JA3A 3QYLA 4XRBA 2W3WA 3HBBA 4KAKA 4H98A 4IXFX 4P66A 4G95A 2ANOA 5HVEA 3SRSX 3OAFA 3IROA 4ELGA 1DREA 4DPHA 3FY9X 1DHFA 3K74A 5HSRA 1DR4A 3GI2A 4ELEA 3DAUA 4XE6X 3TQAA 3FL9A 1ZDRA 4KY4A 5HUIA 3R33A 2CD2A 3E0BA 4H95A 4QLGA 8DFRA 1DRHA 1DDSA 3NXVA 4X5JA 2G6VA 4KJKA 3M09A 3NRRA 3F0BX 1DIUA 4XT7A 3KY8A 1DLRA 3GYFA 1DRAA 1PD8A 4PSSA 3NU0A 5U27A 3F8ZA 4P68A 2DHFA 1RA9A 3NXRA 7DFRA 4EIGA 3DFRA 4KBNA 1M79A 3IRNA 1KMVA 3VCOA 1M78A 1JOMA 3CLBA 2W9SA 3TD8A 3IX9A 2ZZAA 2C2SA 4GH8A
chains in the Genus database with same CATH superfamily
1RX4A 1RG7A 1VJ3A 3F0VX 2CIGA 4QJZD 4KJLA 3ZPGA 4DDRA 1J3IA 3KFYA 3NZCX 3QL3A 3SQYX 3FYWX 4PDJA 3GHCA 1RA8A 3QLYA 2BLCA 5JG0X 2QK8A 3SRQX 1DR2A 3LG4A 3JW3A 4G3MA 1RD7A 5ECXA 4EJ1A 2GD9A 6DFRA 3M08A 3EEJA 3OCHA 3FS6A 1RX5A 4Q0EA 1DR3A 3F0XX 1DAJA 1RA2A 4M2XA 3DL5A 4OSGA 1IA3A 3S3VA 1DISA 4KD7A 3UM8A 4H96A 3ZPCA 1RB3A 3SRUX 1DYRA 4X5FA 4XT5A 3IRMA 5HVBA 3EELA 3SH2A 1LY4A 3CL9A 2H2QA 1DRFA 3QLXA 4Q67A 3KGYA 3TQ9A 3NZ9X 4ELBA 4M7UA 1CD2A 2FZHA 4DFRA 4P3QA 4IXED 4CD2A 3JVXA 1DDRA 4HA9A 3F0QX 1DR1A 4PSTA 3UM6A 3NZDA 5ECCA 3FQZA 3SRWX 4RGCA 5EAJA 1DYIA 3JTWA 3RO9A 1DYHA 4KEBA 4FHBA 1RF7A 2B3ZA 1MVSA 3FRAX 2HM9A 1JUVA 3GHVA 5DXVA 3FQFA 3HJ3A 1LUDA 1D1GA 3K47A 3DG8A 1DHIA 5HSUA 2D5NA 3FREX 3K45A 3DRCA 2KGKA 2L28A 1RX7A 4M6JA 2BL9A 3S9UA 3EEMA 1BOZA 4ECKA 4X5IA 4X5HA 4P3RA 1AI9A 4QLFA 1U70A 1RX8A 1RX6A 3QFXA 1VDRA 3FRFX 1DR7A 3N0HA 3FQ0A 5HT4A 1HFQA 4G8ZX 4HOEA 4QJCA 1AOEA 3JW5A 2W3MA 3DATA 4KNEA 4ELFA 1LY3A 2XW7A 2HQPA 2LF1A 3NXTA 4HOFA 1OHKA 3DGAA 3RG9A 3CSEA 3EIGA 5HI6A 1DG8A 1DHJA 3UM5A 4FGGA 4EILA 5HQZA 5CC9A 2W3BA 1HFPA 1JOLA 3SAIA 5FDAA 4KL9A 4KFJA 3NZAX 4M7VA 1DG5A 3D84X 2AZNA 3FRBX 3NZ6X 3Q1HA 3QLZA 3FQVA 3I8AX 3FQCA 5HQYA 3EX8A 4EIZA 3SGYA 4I13A 4XT8A 4H97A 4X5GA 4LEKX 3QL0A 3L3RA 1KLKA 1U71A 2INQA 5U26A 1IA4A 1U72A 1TDRA 3JWFA 3D80A 2W9TA 3NZBX 4KM2A 2W3VA 2W3AA 1PDBA 2BLAA 2JYBA 1J3JA 2HXVA 3TQBA 4M6KA 5DFRA 1RA1A 3INVA 4HA7A 1RX3A 3K2HA 2D0KA 2O7PA 4Q6AA 4QHVA 1RB2A 3QLWA 4QLEA 5HPBA 3KJRA 1S3YA 3F0SX 1S3WA 2BLBA 3NXOA 1RC4A 2FZIA 3I3RA 4DP3A 3NXYA 3NTZA 3SRRX 1RX1A 3SA1A 4Q0DA 4XECX 1QZFA 2FZJA 3QLRA 3QYOA 3IA4A 1RE7A 3QGTA 1DRBA 4PTHA 2P4GA 4TU5X 4KY8A 1S3VA 3S7AA 5HF2X 1DF7A 1KMSA 4NX6A 3DL6A 1RX2A 3QG2A 5E8QA 3FL8A 1DLSA 2C2TA 4DPDA 3JWMA 4PTJA 3CD2A 3ROAA 4ELHA 1MVTA 5CCCA 3JWKA 3F8YA 4KYAA 4HOGA 5HT5A 1M7AA 3EEKA 4NX7A 3JWCA 1DG7A 4KJJA 1IA1A 1OHJA 3SA2A 1AO8A 3F91A 4LAHX 4XT6A 2OIPA 3FQOA 4KM0A 1E26A 4I1NA 1RA3A 1S3UA 4OR7A 3IA5A 4LAEX 2ANQA 1DR6A 3SR5X 3NXXA 3QLSA 1DYJA 1RX9A 4QI9A 1CZ3A 3GHWA 4LAGX 1RH3A 3KJSA 4IXGX 4M6LA 1SEJA 1J3KA 3TQ8A 3FRDX 2DRCA 1IA2A 2ITHA 1BZFA 1PD9A 2OBCA 1DR5A 3JSUA 4KLXA 4PSYA 1HFRA 4XT4A 1YHOA 3FY8X 5HF0X 3F0UX 4FGHA 3FYVX 2W9HA 2W9GA 5JA3A 3QYLA 4XRBA 2W3WA 3HBBA 4KAKA 4H98A 4IXFX 4P66A 4G95A 2ANOA 5HVEA 3SRSX 3OAFA 3IROA 4ELGA 1DREA 4DPHA 3FY9X 1DHFA 3K74A 5HSRA 1DR4A 3GI2A 4ELEA 3DAUA 4XE6X 3TQAA 3FL9A 1ZDRA 4KY4A 5HUIA 3R33A 2CD2A 3E0BA 4H95A 4QLGA 8DFRA 1DRHA 1DDSA 3NXVA 4X5JA 2G6VA 4KJKA 3M09A 3NRRA 3F0BX 1DIUA 4XT7A 3KY8A 1DLRA 3GYFA 1DRAA 1PD8A 4PSSA 3NU0A 5U27A 3F8ZA 4P68A 2DHFA 1RA9A 3NXRA 7DFRA 4EIGA 3DFRA 4KBNA 1M79A 3IRNA 1KMVA 3VCOA 1M78A 1JOMA 3CLBA 2W9SA 3TD8A 3IX9A 2ZZAA 2C2SA 4GH8A
chains in the Genus database with same CATH topology
1RX4A 1RG7A 1VJ3A 3F0VX 2CIGA 4QJZD 4KJLA 3ZPGA 4DDRA 1J3IA 3KFYA 3NZCX 3QL3A 3SQYX 3FYWX 4PDJA 3GHCA 1RA8A 3QLYA 2BLCA 5JG0X 2QK8A 3SRQX 1DR2A 3LG4A 3JW3A 4G3MA 1RD7A 5ECXA 4EJ1A 2GD9A 6DFRA 3M08A 3EEJA 3OCHA 3FS6A 1RX5A 4Q0EA 1DR3A 3F0XX 1DAJA 1RA2A 4M2XA 3DL5A 4OSGA 1IA3A 3S3VA 1DISA 4KD7A 3UM8A 4H96A 3ZPCA 1RB3A 3SRUX 1DYRA 4X5FA 4XT5A 3IRMA 5HVBA 3EELA 3SH2A 1LY4A 3CL9A 2H2QA 1DRFA 3QLXA 4Q67A 3KGYA 3TQ9A 3NZ9X 4ELBA 4M7UA 1CD2A 2FZHA 4DFRA 4P3QA 4IXED 4CD2A 3JVXA 1DDRA 4HA9A 3F0QX 1DR1A 4PSTA 3UM6A 3NZDA 5ECCA 3FQZA 3SRWX 4RGCA 5EAJA 1DYIA 3JTWA 3RO9A 1DYHA 4KEBA 4FHBA 1RF7A 2B3ZA 1MVSA 3FRAX 2HM9A 1JUVA 3GHVA 5DXVA 3FQFA 3HJ3A 1LUDA 1D1GA 3K47A 3DG8A 1DHIA 5HSUA 2D5NA 3FREX 3K45A 3DRCA 2KGKA 2L28A 1RX7A 4M6JA 2BL9A 3S9UA 3EEMA 1BOZA 4ECKA 4X5IA 4X5HA 4P3RA 1AI9A 4QLFA 1U70A 1RX8A 1RX6A 3QFXA 1VDRA 3FRFX 1DR7A 3N0HA 3FQ0A 5HT4A 1HFQA 4G8ZX 4HOEA 4QJCA 1AOEA 3JW5A 2W3MA 3DATA 4KNEA 4ELFA 1LY3A 2XW7A 2HQPA 2LF1A 3NXTA 4HOFA 1OHKA 3DGAA 3RG9A 3CSEA 3EIGA 5HI6A 1DG8A 1DHJA 3UM5A 4FGGA 4EILA 5HQZA 5CC9A 2W3BA 1HFPA 1JOLA 3SAIA 5FDAA 4KL9A 4KFJA 3NZAX 4M7VA 1DG5A 3D84X 2AZNA 3FRBX 3NZ6X 3Q1HA 3QLZA 3FQVA 3I8AX 3FQCA 5HQYA 3EX8A 4EIZA 3SGYA 4I13A 4XT8A 4H97A 4X5GA 4LEKX 3QL0A 3L3RA 1KLKA 1U71A 2INQA 5U26A 1IA4A 1U72A 1TDRA 3JWFA 3D80A 2W9TA 3NZBX 4KM2A 2W3VA 2W3AA 1PDBA 2BLAA 2JYBA 1J3JA 2HXVA 3TQBA 4M6KA 5DFRA 1RA1A 3INVA 4HA7A 1RX3A 3K2HA 2D0KA 2O7PA 4Q6AA 4QHVA 1RB2A 3QLWA 4QLEA 5HPBA 3KJRA 1S3YA 3F0SX 1S3WA 2BLBA 3NXOA 1RC4A 2FZIA 3I3RA 4DP3A 3NXYA 3NTZA 3SRRX 1RX1A 3SA1A 4Q0DA 4XECX 1QZFA 2FZJA 3QLRA 3QYOA 3IA4A 1RE7A 3QGTA 1DRBA 4PTHA 2P4GA 4TU5X 4KY8A 1S3VA 3S7AA 5HF2X 1DF7A 1KMSA 4NX6A 3DL6A 1RX2A 3QG2A 5E8QA 3FL8A 1DLSA 2C2TA 4DPDA 3JWMA 4PTJA 3CD2A 3ROAA 4ELHA 1MVTA 5CCCA 3JWKA 3F8YA 4KYAA 4HOGA 5HT5A 1M7AA 3EEKA 4NX7A 3JWCA 1DG7A 4KJJA 1IA1A 1OHJA 3SA2A 1AO8A 3F91A 4LAHX 4XT6A 2OIPA 3FQOA 4KM0A 1E26A 4I1NA 1RA3A 1S3UA 4OR7A 3IA5A 4LAEX 2ANQA 1DR6A 3SR5X 3NXXA 3QLSA 1DYJA 1RX9A 4QI9A 1CZ3A 3GHWA 4LAGX 1RH3A 3KJSA 4IXGX 4M6LA 1SEJA 1J3KA 3TQ8A 3FRDX 2DRCA 1IA2A 2ITHA 1BZFA 1PD9A 2OBCA 1DR5A 3JSUA 4KLXA 4PSYA 1HFRA 4XT4A 1YHOA 3FY8X 5HF0X 3F0UX 4FGHA 3FYVX 2W9HA 2W9GA 5JA3A 3QYLA 4XRBA 2W3WA 3HBBA 4KAKA 4H98A 4IXFX 4P66A 4G95A 2ANOA 5HVEA 3SRSX 3OAFA 3IROA 4ELGA 1DREA 4DPHA 3FY9X 1DHFA 3K74A 5HSRA 1DR4A 3GI2A 4ELEA 3DAUA 4XE6X 3TQAA 3FL9A 1ZDRA 4KY4A 5HUIA 3R33A 2CD2A 3E0BA 4H95A 4QLGA 8DFRA 1DRHA 1DDSA 3NXVA 4X5JA 2G6VA 4KJKA 3M09A 3NRRA 3F0BX 1DIUA 4XT7A 3KY8A 1DLRA 3GYFA 1DRAA 1PD8A 4PSSA 3NU0A 5U27A 3F8ZA 4P68A 2DHFA 1RA9A 3NXRA 7DFRA 4EIGA 3DFRA 4KBNA 1M79A 3IRNA 1KMVA 3VCOA 1M78A 1JOMA 3CLBA 2W9SA 3TD8A 3IX9A 2ZZAA 2C2SA 4GH8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RX4 A;  1RG7 A;  1VJ3 A;  3F0V X;  2CIG A;  4QJZ D;  4KJL A;  3ZPG A;  4DDR A;  1J3I A;  3KFY A;  3NZC X;  3QL3 A;  3SQY X;  3FYW X;  4PDJ A;  3GHC A;  1RA8 A;  3QLY A;  2BLC A;  5JG0 X;  2QK8 A;  3SRQ X;  1DR2 A;  3LG4 A;  3JW3 A;  4G3M A;  1RD7 A;  5ECX A;  4EJ1 A;  2GD9 A;  6DFR A;  3M08 A;  3EEJ A;  3OCH A;  3FS6 A;  1RX5 A;  4Q0E A;  1DR3 A;  3F0X X;  1DAJ A;  1RA2 A;  4M2X A;  3DL5 A;  4OSG A;  1IA3 A;  3S3V A;  1DIS A;  4KD7 A;  3UM8 A;  4H96 A;  3ZPC A;  1RB3 A;  3SRU X;  1DYR A;  4X5F A;  4XT5 A;  3IRM A;  5HVB A;  3EEL A;  3SH2 A;  1LY4 A;  3CL9 A;  2H2Q A;  1DRF A;  3QLX A;  4Q67 A;  3KGY A;  3TQ9 A;  3NZ9 X;  4ELB A;  4M7U A;  1CD2 A;  2FZH A;  4DFR A;  4P3Q A;  4IXE D;  4CD2 A;  3JVX A;  1DDR A;  4HA9 A;  3F0Q X;  1DR1 A;  4PST A;  3UM6 A;  3NZD A;  5ECC A;  3FQZ A;  3SRW X;  4RGC A;  5EAJ A;  1DYI A;  3JTW A;  3RO9 A;  1DYH A;  4KEB A;  4FHB A;  1RF7 A;  2B3Z A;  1MVS A;  3FRA X;  2HM9 A;  1JUV A;  3GHV A;  5DXV A;  3FQF A;  3HJ3 A;  1LUD A;  1D1G A;  3K47 A;  3DG8 A;  1DHI A;  5HSU A;  2D5N A;  3FRE X;  3K45 A;  3DRC A;  2KGK A;  2L28 A;  1RX7 A;  4M6J A;  2BL9 A;  3S9U A;  3EEM A;  1BOZ A;  4ECK A;  4X5I A;  4X5H A;  4P3R A;  1AI9 A;  4QLF A;  1U70 A;  1RX8 A;  1RX6 A;  3QFX A;  1VDR A;  3FRF X;  1DR7 A;  3N0H A;  3FQ0 A;  5HT4 A;  1HFQ A;  4G8Z X;  4HOE A;  4QJC A;  1AOE A;  3JW5 A;  2W3M A;  3DAT A;  4KNE A;  4ELF A;  1LY3 A;  2XW7 A;  2HQP A;  2LF1 A;  3NXT A;  4HOF A;  1OHK A;  3DGA A;  3RG9 A;  3CSE A;  3EIG A;  5HI6 A;  1DG8 A;  1DHJ A;  3UM5 A;  4FGG A;  4EIL A;  5HQZ A;  5CC9 A;  2W3B A;  1HFP A;  1JOL A;  3SAI A;  5FDA A;  4KL9 A;  4KFJ A;  3NZA X;  4M7V A;  1DG5 A;  3D84 X;  2AZN A;  3FRB X;  3NZ6 X;  3Q1H A;  3QLZ A;  3FQV A;  3I8A X;  3FQC A;  5HQY A;  3EX8 A;  4EIZ A;  3SGY A;  4I13 A;  4XT8 A;  4H97 A;  4X5G A;  4LEK X;  3QL0 A;  3L3R A;  1KLK A;  1U71 A;  2INQ A;  5U26 A;  1IA4 A;  1U72 A;  1TDR A;  3JWF A;  3D80 A;  2W9T A;  3NZB X;  4KM2 A;  2W3V A;  2W3A A;  1PDB A;  2BLA A;  2JYB A;  1J3J A;  2HXV A;  3TQB A;  4M6K A;  5DFR A;  1RA1 A;  3INV A;  4HA7 A;  1RX3 A;  3K2H A;  2D0K A;  2O7P A;  4Q6A A;  4QHV A;  1RB2 A;  3QLW A;  4QLE A;  5HPB A;  3KJR A;  1S3Y A;  3F0S X;  1S3W A;  2BLB A;  3NXO A;  1RC4 A;  2FZI A;  3I3R A;  4DP3 A;  3NXY A;  3NTZ A;  3SRR X;  1RX1 A;  3SA1 A;  4Q0D A;  4XEC X;  1QZF A;  2FZJ A;  3QLR A;  3QYO A;  3IA4 A;  1RE7 A;  3QGT A;  1DRB A;  4PTH A;  2P4G A;  4TU5 X;  4KY8 A;  1S3V A;  3S7A A;  5HF2 X;  1DF7 A;  1KMS A;  4NX6 A;  3DL6 A;  1RX2 A;  3QG2 A;  5E8Q A;  3FL8 A;  1DLS A;  2C2T A;  4DPD A;  3JWM A;  4PTJ A;  3CD2 A;  3ROA A;  4ELH A;  1MVT A;  5CCC A;  3JWK A;  3F8Y A;  4KYA A;  4HOG A;  5HT5 A;  1M7A A;  3EEK A;  4NX7 A;  3JWC A;  1DG7 A;  4KJJ A;  1IA1 A;  1OHJ A;  3SA2 A;  1AO8 A;  3F91 A;  4LAH X;  4XT6 A;  2OIP A;  3FQO A;  4KM0 A;  1E26 A;  4I1N A;  1RA3 A;  1S3U A;  4OR7 A;  3IA5 A;  4LAE X;  2ANQ A;  1DR6 A;  3SR5 X;  3NXX A;  3QLS A;  1DYJ A;  1RX9 A;  4QI9 A;  1CZ3 A;  3GHW A;  4LAG X;  1RH3 A;  3KJS A;  4IXG X;  4M6L A;  1SEJ A;  1J3K A;  3TQ8 A;  3FRD X;  2DRC A;  1IA2 A;  2ITH A;  1BZF A;  1PD9 A;  2OBC A;  1DR5 A;  3JSU A;  4KLX A;  4PSY A;  1HFR A;  4XT4 A;  1YHO A;  3FY8 X;  5HF0 X;  3F0U X;  4FGH A;  3FYV X;  2W9H A;  2W9G A;  5JA3 A;  3QYL A;  4XRB A;  2W3W A;  3HBB A;  4KAK A;  4H98 A;  4IXF X;  4P66 A;  4G95 A;  2ANO A;  5HVE A;  3SRS X;  3OAF A;  3IRO A;  4ELG A;  1DRE A;  4DPH A;  3FY9 X;  1DHF A;  3K74 A;  5HSR A;  1DR4 A;  3GI2 A;  4ELE A;  3DAU A;  4XE6 X;  3TQA A;  3FL9 A;  1ZDR A;  4KY4 A;  5HUI A;  3R33 A;  2CD2 A;  3E0B A;  4H95 A;  4QLG A;  8DFR A;  1DRH A;  1DDS A;  3NXV A;  4X5J A;  2G6V A;  4KJK A;  3M09 A;  3NRR A;  3F0B X;  1DIU A;  4XT7 A;  3KY8 A;  1DLR A;  3GYF A;  1DRA A;  1PD8 A;  4PSS A;  3NU0 A;  5U27 A;  3F8Z A;  4P68 A;  2DHF A;  1RA9 A;  3NXR A;  7DFR A;  4EIG A;  3DFR A;  4KBN A;  1M79 A;  3IRN A;  1KMV A;  3VCO A;  1M78 A;  1JOM A;  3CLB A;  2W9S A;  3TD8 A;  3IX9 A;  2ZZA A;  2C2S A;  4GH8 A; 
#chains in the Genus database with same CATH topology
 1RX4 A;  1RG7 A;  1VJ3 A;  3F0V X;  2CIG A;  4QJZ D;  4KJL A;  3ZPG A;  4DDR A;  1J3I A;  3KFY A;  3NZC X;  3QL3 A;  3SQY X;  3FYW X;  4PDJ A;  3GHC A;  1RA8 A;  3QLY A;  2BLC A;  5JG0 X;  2QK8 A;  3SRQ X;  1DR2 A;  3LG4 A;  3JW3 A;  4G3M A;  1RD7 A;  5ECX A;  4EJ1 A;  2GD9 A;  6DFR A;  3M08 A;  3EEJ A;  3OCH A;  3FS6 A;  1RX5 A;  4Q0E A;  1DR3 A;  3F0X X;  1DAJ A;  1RA2 A;  4M2X A;  3DL5 A;  4OSG A;  1IA3 A;  3S3V A;  1DIS A;  4KD7 A;  3UM8 A;  4H96 A;  3ZPC A;  1RB3 A;  3SRU X;  1DYR A;  4X5F A;  4XT5 A;  3IRM A;  5HVB A;  3EEL A;  3SH2 A;  1LY4 A;  3CL9 A;  2H2Q A;  1DRF A;  3QLX A;  4Q67 A;  3KGY A;  3TQ9 A;  3NZ9 X;  4ELB A;  4M7U A;  1CD2 A;  2FZH A;  4DFR A;  4P3Q A;  4IXE D;  4CD2 A;  3JVX A;  1DDR A;  4HA9 A;  3F0Q X;  1DR1 A;  4PST A;  3UM6 A;  3NZD A;  5ECC A;  3FQZ A;  3SRW X;  4RGC A;  5EAJ A;  1DYI A;  3JTW A;  3RO9 A;  1DYH A;  4KEB A;  4FHB A;  1RF7 A;  2B3Z A;  1MVS A;  3FRA X;  2HM9 A;  1JUV A;  3GHV A;  5DXV A;  3FQF A;  3HJ3 A;  1LUD A;  1D1G A;  3K47 A;  3DG8 A;  1DHI A;  5HSU A;  2D5N A;  3FRE X;  3K45 A;  3DRC A;  2KGK A;  2L28 A;  1RX7 A;  4M6J A;  2BL9 A;  3S9U A;  3EEM A;  1BOZ A;  4ECK A;  4X5I A;  4X5H A;  4P3R A;  1AI9 A;  4QLF A;  1U70 A;  1RX8 A;  1RX6 A;  3QFX A;  1VDR A;  3FRF X;  1DR7 A;  3N0H A;  3FQ0 A;  5HT4 A;  1HFQ A;  4G8Z X;  4HOE A;  4QJC A;  1AOE A;  3JW5 A;  2W3M A;  3DAT A;  4KNE A;  4ELF A;  1LY3 A;  2XW7 A;  2HQP A;  2LF1 A;  3NXT A;  4HOF A;  1OHK A;  3DGA A;  3RG9 A;  3CSE A;  3EIG A;  5HI6 A;  1DG8 A;  1DHJ A;  3UM5 A;  4FGG A;  4EIL A;  5HQZ A;  5CC9 A;  2W3B A;  1HFP A;  1JOL A;  3SAI A;  5FDA A;  4KL9 A;  4KFJ A;  3NZA X;  4M7V A;  1DG5 A;  3D84 X;  2AZN A;  3FRB X;  3NZ6 X;  3Q1H A;  3QLZ A;  3FQV A;  3I8A X;  3FQC A;  5HQY A;  3EX8 A;  4EIZ A;  3SGY A;  4I13 A;  4XT8 A;  4H97 A;  4X5G A;  4LEK X;  3QL0 A;  3L3R A;  1KLK A;  1U71 A;  2INQ A;  5U26 A;  1IA4 A;  1U72 A;  1TDR A;  3JWF A;  3D80 A;  2W9T A;  3NZB X;  4KM2 A;  2W3V A;  2W3A A;  1PDB A;  2BLA A;  2JYB A;  1J3J A;  2HXV A;  3TQB A;  4M6K A;  5DFR A;  1RA1 A;  3INV A;  4HA7 A;  1RX3 A;  3K2H A;  2D0K A;  2O7P A;  4Q6A A;  4QHV A;  1RB2 A;  3QLW A;  4QLE A;  5HPB A;  3KJR A;  1S3Y A;  3F0S X;  1S3W A;  2BLB A;  3NXO A;  1RC4 A;  2FZI A;  3I3R A;  4DP3 A;  3NXY A;  3NTZ A;  3SRR X;  1RX1 A;  3SA1 A;  4Q0D A;  4XEC X;  1QZF A;  2FZJ A;  3QLR A;  3QYO A;  3IA4 A;  1RE7 A;  3QGT A;  1DRB A;  4PTH A;  2P4G A;  4TU5 X;  4KY8 A;  1S3V A;  3S7A A;  5HF2 X;  1DF7 A;  1KMS A;  4NX6 A;  3DL6 A;  1RX2 A;  3QG2 A;  5E8Q A;  3FL8 A;  1DLS A;  2C2T A;  4DPD A;  3JWM A;  4PTJ A;  3CD2 A;  3ROA A;  4ELH A;  1MVT A;  5CCC A;  3JWK A;  3F8Y A;  4KYA A;  4HOG A;  5HT5 A;  1M7A A;  3EEK A;  4NX7 A;  3JWC A;  1DG7 A;  4KJJ A;  1IA1 A;  1OHJ A;  3SA2 A;  1AO8 A;  3F91 A;  4LAH X;  4XT6 A;  2OIP A;  3FQO A;  4KM0 A;  1E26 A;  4I1N A;  1RA3 A;  1S3U A;  4OR7 A;  3IA5 A;  4LAE X;  2ANQ A;  1DR6 A;  3SR5 X;  3NXX A;  3QLS A;  1DYJ A;  1RX9 A;  4QI9 A;  1CZ3 A;  3GHW A;  4LAG X;  1RH3 A;  3KJS A;  4IXG X;  4M6L A;  1SEJ A;  1J3K A;  3TQ8 A;  3FRD X;  2DRC A;  1IA2 A;  2ITH A;  1BZF A;  1PD9 A;  2OBC A;  1DR5 A;  3JSU A;  4KLX A;  4PSY A;  1HFR A;  4XT4 A;  1YHO A;  3FY8 X;  5HF0 X;  3F0U X;  4FGH A;  3FYV X;  2W9H A;  2W9G A;  5JA3 A;  3QYL A;  4XRB A;  2W3W A;  3HBB A;  4KAK A;  4H98 A;  4IXF X;  4P66 A;  4G95 A;  2ANO A;  5HVE A;  3SRS X;  3OAF A;  3IRO A;  4ELG A;  1DRE A;  4DPH A;  3FY9 X;  1DHF A;  3K74 A;  5HSR A;  1DR4 A;  3GI2 A;  4ELE A;  3DAU A;  4XE6 X;  3TQA A;  3FL9 A;  1ZDR A;  4KY4 A;  5HUI A;  3R33 A;  2CD2 A;  3E0B A;  4H95 A;  4QLG A;  8DFR A;  1DRH A;  1DDS A;  3NXV A;  4X5J A;  2G6V A;  4KJK A;  3M09 A;  3NRR A;  3F0B X;  1DIU A;  4XT7 A;  3KY8 A;  1DLR A;  3GYF A;  1DRA A;  1PD8 A;  4PSS A;  3NU0 A;  5U27 A;  3F8Z A;  4P68 A;  2DHF A;  1RA9 A;  3NXR A;  7DFR A;  4EIG A;  3DFR A;  4KBN A;  1M79 A;  3IRN A;  1KMV A;  3VCO A;  1M78 A;  1JOM A;  3CLB A;  2W9S A;  3TD8 A;  3IX9 A;  2ZZA A;  2C2S A;  4GH8 A; 
#chains in the Genus database with same CATH homology
 1RX4 A;  1RG7 A;  1VJ3 A;  3F0V X;  2CIG A;  4QJZ D;  4KJL A;  3ZPG A;  4DDR A;  1J3I A;  3KFY A;  3NZC X;  3QL3 A;  3SQY X;  3FYW X;  4PDJ A;  3GHC A;  1RA8 A;  3QLY A;  2BLC A;  5JG0 X;  2QK8 A;  3SRQ X;  1DR2 A;  3LG4 A;  3JW3 A;  4G3M A;  1RD7 A;  5ECX A;  4EJ1 A;  2GD9 A;  6DFR A;  3M08 A;  3EEJ A;  3OCH A;  3FS6 A;  1RX5 A;  4Q0E A;  1DR3 A;  3F0X X;  1DAJ A;  1RA2 A;  4M2X A;  3DL5 A;  4OSG A;  1IA3 A;  3S3V A;  1DIS A;  4KD7 A;  3UM8 A;  4H96 A;  3ZPC A;  1RB3 A;  3SRU X;  1DYR A;  4X5F A;  4XT5 A;  3IRM A;  5HVB A;  3EEL A;  3SH2 A;  1LY4 A;  3CL9 A;  2H2Q A;  1DRF A;  3QLX A;  4Q67 A;  3KGY A;  3TQ9 A;  3NZ9 X;  4ELB A;  4M7U A;  1CD2 A;  2FZH A;  4DFR A;  4P3Q A;  4IXE D;  4CD2 A;  3JVX A;  1DDR A;  4HA9 A;  3F0Q X;  1DR1 A;  4PST A;  3UM6 A;  3NZD A;  5ECC A;  3FQZ A;  3SRW X;  4RGC A;  5EAJ A;  1DYI A;  3JTW A;  3RO9 A;  1DYH A;  4KEB A;  4FHB A;  1RF7 A;  2B3Z A;  1MVS A;  3FRA X;  2HM9 A;  1JUV A;  3GHV A;  5DXV A;  3FQF A;  3HJ3 A;  1LUD A;  1D1G A;  3K47 A;  3DG8 A;  1DHI A;  5HSU A;  2D5N A;  3FRE X;  3K45 A;  3DRC A;  2KGK A;  2L28 A;  1RX7 A;  4M6J A;  2BL9 A;  3S9U A;  3EEM A;  1BOZ A;  4ECK A;  4X5I A;  4X5H A;  4P3R A;  1AI9 A;  4QLF A;  1U70 A;  1RX8 A;  1RX6 A;  3QFX A;  1VDR A;  3FRF X;  1DR7 A;  3N0H A;  3FQ0 A;  5HT4 A;  1HFQ A;  4G8Z X;  4HOE A;  4QJC A;  1AOE A;  3JW5 A;  2W3M A;  3DAT A;  4KNE A;  4ELF A;  1LY3 A;  2XW7 A;  2HQP A;  2LF1 A;  3NXT A;  4HOF A;  1OHK A;  3DGA A;  3RG9 A;  3CSE A;  3EIG A;  5HI6 A;  1DG8 A;  1DHJ A;  3UM5 A;  4FGG A;  4EIL A;  5HQZ A;  5CC9 A;  2W3B A;  1HFP A;  1JOL A;  3SAI A;  5FDA A;  4KL9 A;  4KFJ A;  3NZA X;  4M7V A;  1DG5 A;  3D84 X;  2AZN A;  3FRB X;  3NZ6 X;  3Q1H A;  3QLZ A;  3FQV A;  3I8A X;  3FQC A;  5HQY A;  3EX8 A;  4EIZ A;  3SGY A;  4I13 A;  4XT8 A;  4H97 A;  4X5G A;  4LEK X;  3QL0 A;  3L3R A;  1KLK A;  1U71 A;  2INQ A;  5U26 A;  1IA4 A;  1U72 A;  1TDR A;  3JWF A;  3D80 A;  2W9T A;  3NZB X;  4KM2 A;  2W3V A;  2W3A A;  1PDB A;  2BLA A;  2JYB A;  1J3J A;  2HXV A;  3TQB A;  4M6K A;  5DFR A;  1RA1 A;  3INV A;  4HA7 A;  1RX3 A;  3K2H A;  2D0K A;  2O7P A;  4Q6A A;  4QHV A;  1RB2 A;  3QLW A;  4QLE A;  5HPB A;  3KJR A;  1S3Y A;  3F0S X;  1S3W A;  2BLB A;  3NXO A;  1RC4 A;  2FZI A;  3I3R A;  4DP3 A;  3NXY A;  3NTZ A;  3SRR X;  1RX1 A;  3SA1 A;  4Q0D A;  4XEC X;  1QZF A;  2FZJ A;  3QLR A;  3QYO A;  3IA4 A;  1RE7 A;  3QGT A;  1DRB A;  4PTH A;  2P4G A;  4TU5 X;  4KY8 A;  1S3V A;  3S7A A;  5HF2 X;  1DF7 A;  1KMS A;  4NX6 A;  3DL6 A;  1RX2 A;  3QG2 A;  5E8Q A;  3FL8 A;  1DLS A;  2C2T A;  4DPD A;  3JWM A;  4PTJ A;  3CD2 A;  3ROA A;  4ELH A;  1MVT A;  5CCC A;  3JWK A;  3F8Y A;  4KYA A;  4HOG A;  5HT5 A;  1M7A A;  3EEK A;  4NX7 A;  3JWC A;  1DG7 A;  4KJJ A;  1IA1 A;  1OHJ A;  3SA2 A;  1AO8 A;  3F91 A;  4LAH X;  4XT6 A;  2OIP A;  3FQO A;  4KM0 A;  1E26 A;  4I1N A;  1RA3 A;  1S3U A;  4OR7 A;  3IA5 A;  4LAE X;  2ANQ A;  1DR6 A;  3SR5 X;  3NXX A;  3QLS A;  1DYJ A;  1RX9 A;  4QI9 A;  1CZ3 A;  3GHW A;  4LAG X;  1RH3 A;  3KJS A;  4IXG X;  4M6L A;  1SEJ A;  1J3K A;  3TQ8 A;  3FRD X;  2DRC A;  1IA2 A;  2ITH A;  1BZF A;  1PD9 A;  2OBC A;  1DR5 A;  3JSU A;  4KLX A;  4PSY A;  1HFR A;  4XT4 A;  1YHO A;  3FY8 X;  5HF0 X;  3F0U X;  4FGH A;  3FYV X;  2W9H A;  2W9G A;  5JA3 A;  3QYL A;  4XRB A;  2W3W A;  3HBB A;  4KAK A;  4H98 A;  4IXF X;  4P66 A;  4G95 A;  2ANO A;  5HVE A;  3SRS X;  3OAF A;  3IRO A;  4ELG A;  1DRE A;  4DPH A;  3FY9 X;  1DHF A;  3K74 A;  5HSR A;  1DR4 A;  3GI2 A;  4ELE A;  3DAU A;  4XE6 X;  3TQA A;  3FL9 A;  1ZDR A;  4KY4 A;  5HUI A;  3R33 A;  2CD2 A;  3E0B A;  4H95 A;  4QLG A;  8DFR A;  1DRH A;  1DDS A;  3NXV A;  4X5J A;  2G6V A;  4KJK A;  3M09 A;  3NRR A;  3F0B X;  1DIU A;  4XT7 A;  3KY8 A;  1DLR A;  3GYF A;  1DRA A;  1PD8 A;  4PSS A;  3NU0 A;  5U27 A;  3F8Z A;  4P68 A;  2DHF A;  1RA9 A;  3NXR A;  7DFR A;  4EIG A;  3DFR A;  4KBN A;  1M79 A;  3IRN A;  1KMV A;  3VCO A;  1M78 A;  1JOM A;  3CLB A;  2W9S A;  3TD8 A;  3IX9 A;  2ZZA A;  2C2S A;  4GH8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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