1U70A

Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrofolate reductase
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
186
structure length
186
Chain Sequence
VRPLNCIVAVSQNMGIGKNGDRPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Mus musculus
molecule keywords Dihydrofolate reductase
total genus 48
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2004-08-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1u70A00
3NZ6X 1CZ3A 3VCOA 4H98A 1QZFA 4QLFA 3F0QX 2QK8A 1S3YA 1YHOA 3FL8A 1S3VA 3F0UX 1CD2A 3CLBA 4TU5X 5HVBA 3JWKA 1AO8A 5DXVA 5HSRA 4KEBA 3SA2A 1DAJA 4LAGX 4FGGA 1DDRA 4OSGA 4HOGA 2OBCA 4ELGA 3QFXA 1DG7A 3TQBA 2W3WA 3SR5X 3NXVA 4KNEA 1VJ3A 4Q0EA 1LY3A 4EILA 1HFQA 4ELFA 5CC9A 3FY9X 4QLGA 1RX6A 4M2XA 1DHJA 2G6VA 1RX7A 4KM2A 1DLRA 3QL0A 3KGYA 1RB3A 3FL9A 3QGTA 4XRBA 3SRUX 3ZPGA 3EELA 3K47A 4M7VA 3FS6A 1LY4A 2FZIA 1RX4A 3TQ8A 1KLKA 3K45A 3JVXA 3FQ0A 2BL9A 3TQ9A 4DFRA 3TQAA 3DL6A 1RX9A 4KAKA 3QYLA 3NU0A 1DYJA 1DYIA 4Q67A 2ITHA 1SEJA 1DHIA 3NTZA 3QLSA 3JWMA 1J3JA 1DYHA 4X5JA 3HBBA 1DR3A 1IA4A 2W9TA 4P3QA 2JYBA 2DHFA 2H2QA 3LG4A 4XT8A 3FRFX 4IXGX 4LEKX 3IA5A 3FQOA 3NXRA 3ROAA 3FRDX 1RB2A 4ELEA 4ELHA 3QLRA 2W3VA 3SQYX 3EEMA 3KY8A 4DP3A 3I3RA 4KL9A 1OHJA 1HFPA 1TDRA 4KJKA 4PSTA 3D80A 1RA3A 1DHFA 4QI9A 2BLAA 1RX8A 3NZ9X 1M78A 1PDBA 3NZDA 4RGCA 3OCHA 3SAIA 1JOMA 4X5HA 4XT6A 3NRRA 3DFRA 2D5NA 3K74A 4FHBA 4HA7A 3NXYA 1DRFA 3E0BA 3F0BX 1RC4A 3S7AA 3GI2A 4IXED 3M08A 2ZZAA 4PSSA 4EJ1A 4DPDA 3TD8A 3Q1HA 3NXTA 1RX1A 3F0SX 2FZHA 1KMVA 4PDJA 4ECKA 3IX9A 2ANOA 1RD7A 2BLBA 3SH2A 4KJJA 2O7PA 3D84X 1DR5A 3FRAX 1DRHA 3UM5A 4H97A 3IRNA 3JWCA 3FREX 1J3IA 4QJCA 3JSUA 4M6KA 1DR7A 1AOEA 3SRRX 3EIGA 3INVA 3IROA 3QLWA 2AZNA 5DFRA 2XW7A 3FQCA 4XECX 4G95A 4H96A 2KGKA 5HT4A 3DG8A 3SGYA 4KFJA 2W9GA 4QJZD 3FRBX 2W3MA 3GHVA 1ZDRA 5HT5A 5U26A 3DL5A 3QLXA 2B3ZA 3NZBX 3HJ3A 5HUIA 2OIPA 3EEKA 3IRMA 1DF7A 3FQFA 4CD2A 1RA2A 2HM9A 5FDAA 4LAHX 8DFRA 2CD2A 3FQVA 1DR4A 2W9SA 3DATA 1U70A 3NXXA 3F8YA 4KYAA 4KY8A 1DR6A 3R33A 4PSYA 2INQA 3S3VA 4G3MA 4Q6AA 4M6JA 5ECXA 4I13A 4QHVA 6DFRA 3SA1A 1DR2A 5EAJA 1RH3A 4HA9A 4I1NA 1M79A 1S3WA 1RG7A 1DDSA 3I8AX 4EIGA 3NZCX 1RX2A 3JTWA 5HPBA 3FYVX 3DRCA 5U27A 3JWFA 4EIZA 3CL9A 1JUVA 3F0VX 3RO9A 5JA3A 3N0HA 4KLXA 4Q0DA 1HFRA 4HOFA 5HF0X 1MVSA 4NX6A 4KY4A 4XT5A 1E26A 4M6LA 4XT4A 5HF2X 1M7AA 4KD7A 1KMSA 1DREA 1DYRA 3SRWX 1IA1A 4G8ZX 1BOZA 5ECCA 4PTHA 1PD9A 5HQYA 1U71A 3KJRA 4QLEA 3DGAA 3JW3A 3QLYA 3K2HA 4XE6X 3F8ZA 4P66A 4ELBA 2BLCA 3F91A 3JW5A 4KJLA 2C2SA 1PD8A 5HVEA 1BZFA 2W3BA 1JOLA 5E8QA 1IA2A 1DLSA 3RG9A 4H95A 2W3AA 2P4GA 4X5GA 1LUDA 3NXOA 3CSEA 1DRBA 4DPHA 5JG0X 1RA8A 7DFRA 3GHCA 3FYWX 1RF7A 1RE7A 4FGHA 3KFYA 1RX5A 2GD9A 4P3RA 3EEJA 3M09A 2ANQA 1DISA 3GHWA 3F0XX 1AI9A 1J3KA 3KJSA 2LF1A 3FQZA 4PTJA 2CIGA 3SRSX 3S9UA 2HXVA 4XT7A 3IA4A 2FZJA 1DG5A 5HQZA 5HI6A 3NZAX 5HSUA 2D0KA 4LAEX 3UM6A 1DG8A 2HQPA 2W9HA 1DRAA 5CCCA 4IXFX 3CD2A 4NX7A 1RA1A 3DAUA 1D1GA 1S3UA 4X5IA 4X5FA 1MVTA 1RA9A 3QG2A 3ZPCA 2DRCA 4HOEA 4GH8A 4KBNA 4DDRA 3L3RA 1U72A 4KM0A 1RX3A 3QLZA 1VDRA 3GYFA 3OAFA 1OHKA 4M7UA 4OR7A 1DR1A 3QL3A 3SRQX 2L28A 2C2TA 4P68A 1DIUA 1IA3A 3QYOA 3EX8A 3FY8X 3UM8A
chains in the Genus database with same CATH superfamily
3NZ6X 1CZ3A 3VCOA 4H98A 1QZFA 4QLFA 3F0QX 2QK8A 1S3YA 1YHOA 3FL8A 1S3VA 3F0UX 1CD2A 3CLBA 4TU5X 5HVBA 3JWKA 1AO8A 5DXVA 5HSRA 4KEBA 3SA2A 1DAJA 4LAGX 4FGGA 1DDRA 4OSGA 4HOGA 2OBCA 4ELGA 3QFXA 1DG7A 3TQBA 2W3WA 3SR5X 3NXVA 4KNEA 1VJ3A 4Q0EA 1LY3A 4EILA 1HFQA 4ELFA 5CC9A 3FY9X 4QLGA 1RX6A 4M2XA 1DHJA 2G6VA 1RX7A 4KM2A 1DLRA 3QL0A 3KGYA 1RB3A 3FL9A 3QGTA 4XRBA 3SRUX 3ZPGA 3EELA 3K47A 4M7VA 3FS6A 1LY4A 2FZIA 1RX4A 3TQ8A 1KLKA 3K45A 3JVXA 3FQ0A 2BL9A 3TQ9A 4DFRA 3TQAA 3DL6A 1RX9A 4KAKA 3QYLA 3NU0A 1DYJA 1DYIA 4Q67A 2ITHA 1SEJA 1DHIA 3NTZA 3QLSA 3JWMA 1J3JA 1DYHA 4X5JA 3HBBA 1DR3A 1IA4A 2W9TA 4P3QA 2JYBA 2DHFA 2H2QA 3LG4A 4XT8A 3FRFX 4IXGX 4LEKX 3IA5A 3FQOA 3NXRA 3ROAA 3FRDX 1RB2A 4ELEA 4ELHA 3QLRA 2W3VA 3SQYX 3EEMA 3KY8A 4DP3A 3I3RA 4KL9A 1OHJA 1HFPA 1TDRA 4KJKA 4PSTA 3D80A 1RA3A 1DHFA 4QI9A 2BLAA 1RX8A 3NZ9X 1M78A 1PDBA 3NZDA 4RGCA 3OCHA 3SAIA 1JOMA 4X5HA 4XT6A 3NRRA 3DFRA 2D5NA 3K74A 4FHBA 4HA7A 3NXYA 1DRFA 3E0BA 3F0BX 1RC4A 3S7AA 3GI2A 4IXED 3M08A 2ZZAA 4PSSA 4EJ1A 4DPDA 3TD8A 3Q1HA 3NXTA 1RX1A 3F0SX 2FZHA 1KMVA 4PDJA 4ECKA 3IX9A 2ANOA 1RD7A 2BLBA 3SH2A 4KJJA 2O7PA 3D84X 1DR5A 3FRAX 1DRHA 3UM5A 4H97A 3IRNA 3JWCA 3FREX 1J3IA 4QJCA 3JSUA 4M6KA 1DR7A 1AOEA 3SRRX 3EIGA 3INVA 3IROA 3QLWA 2AZNA 5DFRA 2XW7A 3FQCA 4XECX 4G95A 4H96A 2KGKA 5HT4A 3DG8A 3SGYA 4KFJA 2W9GA 4QJZD 3FRBX 2W3MA 3GHVA 1ZDRA 5HT5A 5U26A 3DL5A 3QLXA 2B3ZA 3NZBX 3HJ3A 5HUIA 2OIPA 3EEKA 3IRMA 1DF7A 3FQFA 4CD2A 1RA2A 2HM9A 5FDAA 4LAHX 8DFRA 2CD2A 3FQVA 1DR4A 2W9SA 3DATA 1U70A 3NXXA 3F8YA 4KYAA 4KY8A 1DR6A 3R33A 4PSYA 2INQA 3S3VA 4G3MA 4Q6AA 4M6JA 5ECXA 4I13A 4QHVA 6DFRA 3SA1A 1DR2A 5EAJA 1RH3A 4HA9A 4I1NA 1M79A 1S3WA 1RG7A 1DDSA 3I8AX 4EIGA 3NZCX 1RX2A 3JTWA 5HPBA 3FYVX 3DRCA 5U27A 3JWFA 4EIZA 3CL9A 1JUVA 3F0VX 3RO9A 5JA3A 3N0HA 4KLXA 4Q0DA 1HFRA 4HOFA 5HF0X 1MVSA 4NX6A 4KY4A 4XT5A 1E26A 4M6LA 4XT4A 5HF2X 1M7AA 4KD7A 1KMSA 1DREA 1DYRA 3SRWX 1IA1A 4G8ZX 1BOZA 5ECCA 4PTHA 1PD9A 5HQYA 1U71A 3KJRA 4QLEA 3DGAA 3JW3A 3QLYA 3K2HA 4XE6X 3F8ZA 4P66A 4ELBA 2BLCA 3F91A 3JW5A 4KJLA 2C2SA 1PD8A 5HVEA 1BZFA 2W3BA 1JOLA 5E8QA 1IA2A 1DLSA 3RG9A 4H95A 2W3AA 2P4GA 4X5GA 1LUDA 3NXOA 3CSEA 1DRBA 4DPHA 5JG0X 1RA8A 7DFRA 3GHCA 3FYWX 1RF7A 1RE7A 4FGHA 3KFYA 1RX5A 2GD9A 4P3RA 3EEJA 3M09A 2ANQA 1DISA 3GHWA 3F0XX 1AI9A 1J3KA 3KJSA 2LF1A 3FQZA 4PTJA 2CIGA 3SRSX 3S9UA 2HXVA 4XT7A 3IA4A 2FZJA 1DG5A 5HQZA 5HI6A 3NZAX 5HSUA 2D0KA 4LAEX 3UM6A 1DG8A 2HQPA 2W9HA 1DRAA 5CCCA 4IXFX 3CD2A 4NX7A 1RA1A 3DAUA 1D1GA 1S3UA 4X5IA 4X5FA 1MVTA 1RA9A 3QG2A 3ZPCA 2DRCA 4HOEA 4GH8A 4KBNA 4DDRA 3L3RA 1U72A 4KM0A 1RX3A 3QLZA 1VDRA 3GYFA 3OAFA 1OHKA 4M7UA 4OR7A 1DR1A 3QL3A 3SRQX 2L28A 2C2TA 4P68A 1DIUA 1IA3A 3QYOA 3EX8A 3FY8X 3UM8A
chains in the Genus database with same CATH topology
3NZ6X 1CZ3A 3VCOA 4H98A 1QZFA 4QLFA 3F0QX 2QK8A 1S3YA 1YHOA 3FL8A 1S3VA 3F0UX 1CD2A 3CLBA 4TU5X 5HVBA 3JWKA 1AO8A 5DXVA 5HSRA 4KEBA 3SA2A 1DAJA 4LAGX 4FGGA 1DDRA 4OSGA 4HOGA 2OBCA 4ELGA 3QFXA 1DG7A 3TQBA 2W3WA 3SR5X 3NXVA 4KNEA 1VJ3A 4Q0EA 1LY3A 4EILA 1HFQA 4ELFA 5CC9A 3FY9X 4QLGA 1RX6A 4M2XA 1DHJA 2G6VA 1RX7A 4KM2A 1DLRA 3QL0A 3KGYA 1RB3A 3FL9A 3QGTA 4XRBA 3SRUX 3ZPGA 3EELA 3K47A 4M7VA 3FS6A 1LY4A 2FZIA 1RX4A 3TQ8A 1KLKA 3K45A 3JVXA 3FQ0A 2BL9A 3TQ9A 4DFRA 3TQAA 3DL6A 1RX9A 4KAKA 3QYLA 3NU0A 1DYJA 1DYIA 4Q67A 2ITHA 1SEJA 1DHIA 3NTZA 3QLSA 3JWMA 1J3JA 1DYHA 4X5JA 3HBBA 1DR3A 1IA4A 2W9TA 4P3QA 2JYBA 2DHFA 2H2QA 3LG4A 4XT8A 3FRFX 4IXGX 4LEKX 3IA5A 3FQOA 3NXRA 3ROAA 3FRDX 1RB2A 4ELEA 4ELHA 3QLRA 2W3VA 3SQYX 3EEMA 3KY8A 4DP3A 3I3RA 4KL9A 1OHJA 1HFPA 1TDRA 4KJKA 4PSTA 3D80A 1RA3A 1DHFA 4QI9A 2BLAA 1RX8A 3NZ9X 1M78A 1PDBA 3NZDA 4RGCA 3OCHA 3SAIA 1JOMA 4X5HA 4XT6A 3NRRA 3DFRA 2D5NA 3K74A 4FHBA 4HA7A 3NXYA 1DRFA 3E0BA 3F0BX 1RC4A 3S7AA 3GI2A 4IXED 3M08A 2ZZAA 4PSSA 4EJ1A 4DPDA 3TD8A 3Q1HA 3NXTA 1RX1A 3F0SX 2FZHA 1KMVA 4PDJA 4ECKA 3IX9A 2ANOA 1RD7A 2BLBA 3SH2A 4KJJA 2O7PA 3D84X 1DR5A 3FRAX 1DRHA 3UM5A 4H97A 3IRNA 3JWCA 3FREX 1J3IA 4QJCA 3JSUA 4M6KA 1DR7A 1AOEA 3SRRX 3EIGA 3INVA 3IROA 3QLWA 2AZNA 5DFRA 2XW7A 3FQCA 4XECX 4G95A 4H96A 2KGKA 5HT4A 3DG8A 3SGYA 4KFJA 2W9GA 4QJZD 3FRBX 2W3MA 3GHVA 1ZDRA 5HT5A 5U26A 3DL5A 3QLXA 2B3ZA 3NZBX 3HJ3A 5HUIA 2OIPA 3EEKA 3IRMA 1DF7A 3FQFA 4CD2A 1RA2A 2HM9A 5FDAA 4LAHX 8DFRA 2CD2A 3FQVA 1DR4A 2W9SA 3DATA 1U70A 3NXXA 3F8YA 4KYAA 4KY8A 1DR6A 3R33A 4PSYA 2INQA 3S3VA 4G3MA 4Q6AA 4M6JA 5ECXA 4I13A 4QHVA 6DFRA 3SA1A 1DR2A 5EAJA 1RH3A 4HA9A 4I1NA 1M79A 1S3WA 1RG7A 1DDSA 3I8AX 4EIGA 3NZCX 1RX2A 3JTWA 5HPBA 3FYVX 3DRCA 5U27A 3JWFA 4EIZA 3CL9A 1JUVA 3F0VX 3RO9A 5JA3A 3N0HA 4KLXA 4Q0DA 1HFRA 4HOFA 5HF0X 1MVSA 4NX6A 4KY4A 4XT5A 1E26A 4M6LA 4XT4A 5HF2X 1M7AA 4KD7A 1KMSA 1DREA 1DYRA 3SRWX 1IA1A 4G8ZX 1BOZA 5ECCA 4PTHA 1PD9A 5HQYA 1U71A 3KJRA 4QLEA 3DGAA 3JW3A 3QLYA 3K2HA 4XE6X 3F8ZA 4P66A 4ELBA 2BLCA 3F91A 3JW5A 4KJLA 2C2SA 1PD8A 5HVEA 1BZFA 2W3BA 1JOLA 5E8QA 1IA2A 1DLSA 3RG9A 4H95A 2W3AA 2P4GA 4X5GA 1LUDA 3NXOA 3CSEA 1DRBA 4DPHA 5JG0X 1RA8A 7DFRA 3GHCA 3FYWX 1RF7A 1RE7A 4FGHA 3KFYA 1RX5A 2GD9A 4P3RA 3EEJA 3M09A 2ANQA 1DISA 3GHWA 3F0XX 1AI9A 1J3KA 3KJSA 2LF1A 3FQZA 4PTJA 2CIGA 3SRSX 3S9UA 2HXVA 4XT7A 3IA4A 2FZJA 1DG5A 5HQZA 5HI6A 3NZAX 5HSUA 2D0KA 4LAEX 3UM6A 1DG8A 2HQPA 2W9HA 1DRAA 5CCCA 4IXFX 3CD2A 4NX7A 1RA1A 3DAUA 1D1GA 1S3UA 4X5IA 4X5FA 1MVTA 1RA9A 3QG2A 3ZPCA 2DRCA 4HOEA 4GH8A 4KBNA 4DDRA 3L3RA 1U72A 4KM0A 1RX3A 3QLZA 1VDRA 3GYFA 3OAFA 1OHKA 4M7UA 4OR7A 1DR1A 3QL3A 3SRQX 2L28A 2C2TA 4P68A 1DIUA 1IA3A 3QYOA 3EX8A 3FY8X 3UM8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NZ6 X;  1CZ3 A;  3VCO A;  4H98 A;  1QZF A;  4QLF A;  3F0Q X;  2QK8 A;  1S3Y A;  1YHO A;  3FL8 A;  1S3V A;  3F0U X;  1CD2 A;  3CLB A;  4TU5 X;  5HVB A;  3JWK A;  1AO8 A;  5DXV A;  5HSR A;  4KEB A;  3SA2 A;  1DAJ A;  4LAG X;  4FGG A;  1DDR A;  4OSG A;  4HOG A;  2OBC A;  4ELG A;  3QFX A;  1DG7 A;  3TQB A;  2W3W A;  3SR5 X;  3NXV A;  4KNE A;  1VJ3 A;  4Q0E A;  1LY3 A;  4EIL A;  1HFQ A;  4ELF A;  5CC9 A;  3FY9 X;  4QLG A;  1RX6 A;  4M2X A;  1DHJ A;  2G6V A;  1RX7 A;  4KM2 A;  1DLR A;  3QL0 A;  3KGY A;  1RB3 A;  3FL9 A;  3QGT A;  4XRB A;  3SRU X;  3ZPG A;  3EEL A;  3K47 A;  4M7V A;  3FS6 A;  1LY4 A;  2FZI A;  1RX4 A;  3TQ8 A;  1KLK A;  3K45 A;  3JVX A;  3FQ0 A;  2BL9 A;  3TQ9 A;  4DFR A;  3TQA A;  3DL6 A;  1RX9 A;  4KAK A;  3QYL A;  3NU0 A;  1DYJ A;  1DYI A;  4Q67 A;  2ITH A;  1SEJ A;  1DHI A;  3NTZ A;  3QLS A;  3JWM A;  1J3J A;  1DYH A;  4X5J A;  3HBB A;  1DR3 A;  1IA4 A;  2W9T A;  4P3Q A;  2JYB A;  2DHF A;  2H2Q A;  3LG4 A;  4XT8 A;  3FRF X;  4IXG X;  4LEK X;  3IA5 A;  3FQO A;  3NXR A;  3ROA A;  3FRD X;  1RB2 A;  4ELE A;  4ELH A;  3QLR A;  2W3V A;  3SQY X;  3EEM A;  3KY8 A;  4DP3 A;  3I3R A;  4KL9 A;  1OHJ A;  1HFP A;  1TDR A;  4KJK A;  4PST A;  3D80 A;  1RA3 A;  1DHF A;  4QI9 A;  2BLA A;  1RX8 A;  3NZ9 X;  1M78 A;  1PDB A;  3NZD A;  4RGC A;  3OCH A;  3SAI A;  1JOM A;  4X5H A;  4XT6 A;  3NRR A;  3DFR A;  2D5N A;  3K74 A;  4FHB A;  4HA7 A;  3NXY A;  1DRF A;  3E0B A;  3F0B X;  1RC4 A;  3S7A A;  3GI2 A;  4IXE D;  3M08 A;  2ZZA A;  4PSS A;  4EJ1 A;  4DPD A;  3TD8 A;  3Q1H A;  3NXT A;  1RX1 A;  3F0S X;  2FZH A;  1KMV A;  4PDJ A;  4ECK A;  3IX9 A;  2ANO A;  1RD7 A;  2BLB A;  3SH2 A;  4KJJ A;  2O7P A;  3D84 X;  1DR5 A;  3FRA X;  1DRH A;  3UM5 A;  4H97 A;  3IRN A;  3JWC A;  3FRE X;  1J3I A;  4QJC A;  3JSU A;  4M6K A;  1DR7 A;  1AOE A;  3SRR X;  3EIG A;  3INV A;  3IRO A;  3QLW A;  2AZN A;  5DFR A;  2XW7 A;  3FQC A;  4XEC X;  4G95 A;  4H96 A;  2KGK A;  5HT4 A;  3DG8 A;  3SGY A;  4KFJ A;  2W9G A;  4QJZ D;  3FRB X;  2W3M A;  3GHV A;  1ZDR A;  5HT5 A;  5U26 A;  3DL5 A;  3QLX A;  2B3Z A;  3NZB X;  3HJ3 A;  5HUI A;  2OIP A;  3EEK A;  3IRM A;  1DF7 A;  3FQF A;  4CD2 A;  1RA2 A;  2HM9 A;  5FDA A;  4LAH X;  8DFR A;  2CD2 A;  3FQV A;  1DR4 A;  2W9S A;  3DAT A;  1U70 A;  3NXX A;  3F8Y A;  4KYA A;  4KY8 A;  1DR6 A;  3R33 A;  4PSY A;  2INQ A;  3S3V A;  4G3M A;  4Q6A A;  4M6J A;  5ECX A;  4I13 A;  4QHV A;  6DFR A;  3SA1 A;  1DR2 A;  5EAJ A;  1RH3 A;  4HA9 A;  4I1N A;  1M79 A;  1S3W A;  1RG7 A;  1DDS A;  3I8A X;  4EIG A;  3NZC X;  1RX2 A;  3JTW A;  5HPB A;  3FYV X;  3DRC A;  5U27 A;  3JWF A;  4EIZ A;  3CL9 A;  1JUV A;  3F0V X;  3RO9 A;  5JA3 A;  3N0H A;  4KLX A;  4Q0D A;  1HFR A;  4HOF A;  5HF0 X;  1MVS A;  4NX6 A;  4KY4 A;  4XT5 A;  1E26 A;  4M6L A;  4XT4 A;  5HF2 X;  1M7A A;  4KD7 A;  1KMS A;  1DRE A;  1DYR A;  3SRW X;  1IA1 A;  4G8Z X;  1BOZ A;  5ECC A;  4PTH A;  1PD9 A;  5HQY A;  1U71 A;  3KJR A;  4QLE A;  3DGA A;  3JW3 A;  3QLY A;  3K2H A;  4XE6 X;  3F8Z A;  4P66 A;  4ELB A;  2BLC A;  3F91 A;  3JW5 A;  4KJL A;  2C2S A;  1PD8 A;  5HVE A;  1BZF A;  2W3B A;  1JOL A;  5E8Q A;  1IA2 A;  1DLS A;  3RG9 A;  4H95 A;  2W3A A;  2P4G A;  4X5G A;  1LUD A;  3NXO A;  3CSE A;  1DRB A;  4DPH A;  5JG0 X;  1RA8 A;  7DFR A;  3GHC A;  3FYW X;  1RF7 A;  1RE7 A;  4FGH A;  3KFY A;  1RX5 A;  2GD9 A;  4P3R A;  3EEJ A;  3M09 A;  2ANQ A;  1DIS A;  3GHW A;  3F0X X;  1AI9 A;  1J3K A;  3KJS A;  2LF1 A;  3FQZ A;  4PTJ A;  2CIG A;  3SRS X;  3S9U A;  2HXV A;  4XT7 A;  3IA4 A;  2FZJ A;  1DG5 A;  5HQZ A;  5HI6 A;  3NZA X;  5HSU A;  2D0K A;  4LAE X;  3UM6 A;  1DG8 A;  2HQP A;  2W9H A;  1DRA A;  5CCC A;  4IXF X;  3CD2 A;  4NX7 A;  1RA1 A;  3DAU A;  1D1G A;  1S3U A;  4X5I A;  4X5F A;  1MVT A;  1RA9 A;  3QG2 A;  3ZPC A;  2DRC A;  4HOE A;  4GH8 A;  4KBN A;  4DDR A;  3L3R A;  1U72 A;  4KM0 A;  1RX3 A;  3QLZ A;  1VDR A;  3GYF A;  3OAF A;  1OHK A;  4M7U A;  4OR7 A;  1DR1 A;  3QL3 A;  3SRQ X;  2L28 A;  2C2T A;  4P68 A;  1DIU A;  1IA3 A;  3QYO A;  3EX8 A;  3FY8 X;  3UM8 A; 
#chains in the Genus database with same CATH topology
 3NZ6 X;  1CZ3 A;  3VCO A;  4H98 A;  1QZF A;  4QLF A;  3F0Q X;  2QK8 A;  1S3Y A;  1YHO A;  3FL8 A;  1S3V A;  3F0U X;  1CD2 A;  3CLB A;  4TU5 X;  5HVB A;  3JWK A;  1AO8 A;  5DXV A;  5HSR A;  4KEB A;  3SA2 A;  1DAJ A;  4LAG X;  4FGG A;  1DDR A;  4OSG A;  4HOG A;  2OBC A;  4ELG A;  3QFX A;  1DG7 A;  3TQB A;  2W3W A;  3SR5 X;  3NXV A;  4KNE A;  1VJ3 A;  4Q0E A;  1LY3 A;  4EIL A;  1HFQ A;  4ELF A;  5CC9 A;  3FY9 X;  4QLG A;  1RX6 A;  4M2X A;  1DHJ A;  2G6V A;  1RX7 A;  4KM2 A;  1DLR A;  3QL0 A;  3KGY A;  1RB3 A;  3FL9 A;  3QGT A;  4XRB A;  3SRU X;  3ZPG A;  3EEL A;  3K47 A;  4M7V A;  3FS6 A;  1LY4 A;  2FZI A;  1RX4 A;  3TQ8 A;  1KLK A;  3K45 A;  3JVX A;  3FQ0 A;  2BL9 A;  3TQ9 A;  4DFR A;  3TQA A;  3DL6 A;  1RX9 A;  4KAK A;  3QYL A;  3NU0 A;  1DYJ A;  1DYI A;  4Q67 A;  2ITH A;  1SEJ A;  1DHI A;  3NTZ A;  3QLS A;  3JWM A;  1J3J A;  1DYH A;  4X5J A;  3HBB A;  1DR3 A;  1IA4 A;  2W9T A;  4P3Q A;  2JYB A;  2DHF A;  2H2Q A;  3LG4 A;  4XT8 A;  3FRF X;  4IXG X;  4LEK X;  3IA5 A;  3FQO A;  3NXR A;  3ROA A;  3FRD X;  1RB2 A;  4ELE A;  4ELH A;  3QLR A;  2W3V A;  3SQY X;  3EEM A;  3KY8 A;  4DP3 A;  3I3R A;  4KL9 A;  1OHJ A;  1HFP A;  1TDR A;  4KJK A;  4PST A;  3D80 A;  1RA3 A;  1DHF A;  4QI9 A;  2BLA A;  1RX8 A;  3NZ9 X;  1M78 A;  1PDB A;  3NZD A;  4RGC A;  3OCH A;  3SAI A;  1JOM A;  4X5H A;  4XT6 A;  3NRR A;  3DFR A;  2D5N A;  3K74 A;  4FHB A;  4HA7 A;  3NXY A;  1DRF A;  3E0B A;  3F0B X;  1RC4 A;  3S7A A;  3GI2 A;  4IXE D;  3M08 A;  2ZZA A;  4PSS A;  4EJ1 A;  4DPD A;  3TD8 A;  3Q1H A;  3NXT A;  1RX1 A;  3F0S X;  2FZH A;  1KMV A;  4PDJ A;  4ECK A;  3IX9 A;  2ANO A;  1RD7 A;  2BLB A;  3SH2 A;  4KJJ A;  2O7P A;  3D84 X;  1DR5 A;  3FRA X;  1DRH A;  3UM5 A;  4H97 A;  3IRN A;  3JWC A;  3FRE X;  1J3I A;  4QJC A;  3JSU A;  4M6K A;  1DR7 A;  1AOE A;  3SRR X;  3EIG A;  3INV A;  3IRO A;  3QLW A;  2AZN A;  5DFR A;  2XW7 A;  3FQC A;  4XEC X;  4G95 A;  4H96 A;  2KGK A;  5HT4 A;  3DG8 A;  3SGY A;  4KFJ A;  2W9G A;  4QJZ D;  3FRB X;  2W3M A;  3GHV A;  1ZDR A;  5HT5 A;  5U26 A;  3DL5 A;  3QLX A;  2B3Z A;  3NZB X;  3HJ3 A;  5HUI A;  2OIP A;  3EEK A;  3IRM A;  1DF7 A;  3FQF A;  4CD2 A;  1RA2 A;  2HM9 A;  5FDA A;  4LAH X;  8DFR A;  2CD2 A;  3FQV A;  1DR4 A;  2W9S A;  3DAT A;  1U70 A;  3NXX A;  3F8Y A;  4KYA A;  4KY8 A;  1DR6 A;  3R33 A;  4PSY A;  2INQ A;  3S3V A;  4G3M A;  4Q6A A;  4M6J A;  5ECX A;  4I13 A;  4QHV A;  6DFR A;  3SA1 A;  1DR2 A;  5EAJ A;  1RH3 A;  4HA9 A;  4I1N A;  1M79 A;  1S3W A;  1RG7 A;  1DDS A;  3I8A X;  4EIG A;  3NZC X;  1RX2 A;  3JTW A;  5HPB A;  3FYV X;  3DRC A;  5U27 A;  3JWF A;  4EIZ A;  3CL9 A;  1JUV A;  3F0V X;  3RO9 A;  5JA3 A;  3N0H A;  4KLX A;  4Q0D A;  1HFR A;  4HOF A;  5HF0 X;  1MVS A;  4NX6 A;  4KY4 A;  4XT5 A;  1E26 A;  4M6L A;  4XT4 A;  5HF2 X;  1M7A A;  4KD7 A;  1KMS A;  1DRE A;  1DYR A;  3SRW X;  1IA1 A;  4G8Z X;  1BOZ A;  5ECC A;  4PTH A;  1PD9 A;  5HQY A;  1U71 A;  3KJR A;  4QLE A;  3DGA A;  3JW3 A;  3QLY A;  3K2H A;  4XE6 X;  3F8Z A;  4P66 A;  4ELB A;  2BLC A;  3F91 A;  3JW5 A;  4KJL A;  2C2S A;  1PD8 A;  5HVE A;  1BZF A;  2W3B A;  1JOL A;  5E8Q A;  1IA2 A;  1DLS A;  3RG9 A;  4H95 A;  2W3A A;  2P4G A;  4X5G A;  1LUD A;  3NXO A;  3CSE A;  1DRB A;  4DPH A;  5JG0 X;  1RA8 A;  7DFR A;  3GHC A;  3FYW X;  1RF7 A;  1RE7 A;  4FGH A;  3KFY A;  1RX5 A;  2GD9 A;  4P3R A;  3EEJ A;  3M09 A;  2ANQ A;  1DIS A;  3GHW A;  3F0X X;  1AI9 A;  1J3K A;  3KJS A;  2LF1 A;  3FQZ A;  4PTJ A;  2CIG A;  3SRS X;  3S9U A;  2HXV A;  4XT7 A;  3IA4 A;  2FZJ A;  1DG5 A;  5HQZ A;  5HI6 A;  3NZA X;  5HSU A;  2D0K A;  4LAE X;  3UM6 A;  1DG8 A;  2HQP A;  2W9H A;  1DRA A;  5CCC A;  4IXF X;  3CD2 A;  4NX7 A;  1RA1 A;  3DAU A;  1D1G A;  1S3U A;  4X5I A;  4X5F A;  1MVT A;  1RA9 A;  3QG2 A;  3ZPC A;  2DRC A;  4HOE A;  4GH8 A;  4KBN A;  4DDR A;  3L3R A;  1U72 A;  4KM0 A;  1RX3 A;  3QLZ A;  1VDR A;  3GYF A;  3OAF A;  1OHK A;  4M7U A;  4OR7 A;  1DR1 A;  3QL3 A;  3SRQ X;  2L28 A;  2C2T A;  4P68 A;  1DIU A;  1IA3 A;  3QYO A;  3EX8 A;  3FY8 X;  3UM8 A; 
#chains in the Genus database with same CATH homology
 3NZ6 X;  1CZ3 A;  3VCO A;  4H98 A;  1QZF A;  4QLF A;  3F0Q X;  2QK8 A;  1S3Y A;  1YHO A;  3FL8 A;  1S3V A;  3F0U X;  1CD2 A;  3CLB A;  4TU5 X;  5HVB A;  3JWK A;  1AO8 A;  5DXV A;  5HSR A;  4KEB A;  3SA2 A;  1DAJ A;  4LAG X;  4FGG A;  1DDR A;  4OSG A;  4HOG A;  2OBC A;  4ELG A;  3QFX A;  1DG7 A;  3TQB A;  2W3W A;  3SR5 X;  3NXV A;  4KNE A;  1VJ3 A;  4Q0E A;  1LY3 A;  4EIL A;  1HFQ A;  4ELF A;  5CC9 A;  3FY9 X;  4QLG A;  1RX6 A;  4M2X A;  1DHJ A;  2G6V A;  1RX7 A;  4KM2 A;  1DLR A;  3QL0 A;  3KGY A;  1RB3 A;  3FL9 A;  3QGT A;  4XRB A;  3SRU X;  3ZPG A;  3EEL A;  3K47 A;  4M7V A;  3FS6 A;  1LY4 A;  2FZI A;  1RX4 A;  3TQ8 A;  1KLK A;  3K45 A;  3JVX A;  3FQ0 A;  2BL9 A;  3TQ9 A;  4DFR A;  3TQA A;  3DL6 A;  1RX9 A;  4KAK A;  3QYL A;  3NU0 A;  1DYJ A;  1DYI A;  4Q67 A;  2ITH A;  1SEJ A;  1DHI A;  3NTZ A;  3QLS A;  3JWM A;  1J3J A;  1DYH A;  4X5J A;  3HBB A;  1DR3 A;  1IA4 A;  2W9T A;  4P3Q A;  2JYB A;  2DHF A;  2H2Q A;  3LG4 A;  4XT8 A;  3FRF X;  4IXG X;  4LEK X;  3IA5 A;  3FQO A;  3NXR A;  3ROA A;  3FRD X;  1RB2 A;  4ELE A;  4ELH A;  3QLR A;  2W3V A;  3SQY X;  3EEM A;  3KY8 A;  4DP3 A;  3I3R A;  4KL9 A;  1OHJ A;  1HFP A;  1TDR A;  4KJK A;  4PST A;  3D80 A;  1RA3 A;  1DHF A;  4QI9 A;  2BLA A;  1RX8 A;  3NZ9 X;  1M78 A;  1PDB A;  3NZD A;  4RGC A;  3OCH A;  3SAI A;  1JOM A;  4X5H A;  4XT6 A;  3NRR A;  3DFR A;  2D5N A;  3K74 A;  4FHB A;  4HA7 A;  3NXY A;  1DRF A;  3E0B A;  3F0B X;  1RC4 A;  3S7A A;  3GI2 A;  4IXE D;  3M08 A;  2ZZA A;  4PSS A;  4EJ1 A;  4DPD A;  3TD8 A;  3Q1H A;  3NXT A;  1RX1 A;  3F0S X;  2FZH A;  1KMV A;  4PDJ A;  4ECK A;  3IX9 A;  2ANO A;  1RD7 A;  2BLB A;  3SH2 A;  4KJJ A;  2O7P A;  3D84 X;  1DR5 A;  3FRA X;  1DRH A;  3UM5 A;  4H97 A;  3IRN A;  3JWC A;  3FRE X;  1J3I A;  4QJC A;  3JSU A;  4M6K A;  1DR7 A;  1AOE A;  3SRR X;  3EIG A;  3INV A;  3IRO A;  3QLW A;  2AZN A;  5DFR A;  2XW7 A;  3FQC A;  4XEC X;  4G95 A;  4H96 A;  2KGK A;  5HT4 A;  3DG8 A;  3SGY A;  4KFJ A;  2W9G A;  4QJZ D;  3FRB X;  2W3M A;  3GHV A;  1ZDR A;  5HT5 A;  5U26 A;  3DL5 A;  3QLX A;  2B3Z A;  3NZB X;  3HJ3 A;  5HUI A;  2OIP A;  3EEK A;  3IRM A;  1DF7 A;  3FQF A;  4CD2 A;  1RA2 A;  2HM9 A;  5FDA A;  4LAH X;  8DFR A;  2CD2 A;  3FQV A;  1DR4 A;  2W9S A;  3DAT A;  1U70 A;  3NXX A;  3F8Y A;  4KYA A;  4KY8 A;  1DR6 A;  3R33 A;  4PSY A;  2INQ A;  3S3V A;  4G3M A;  4Q6A A;  4M6J A;  5ECX A;  4I13 A;  4QHV A;  6DFR A;  3SA1 A;  1DR2 A;  5EAJ A;  1RH3 A;  4HA9 A;  4I1N A;  1M79 A;  1S3W A;  1RG7 A;  1DDS A;  3I8A X;  4EIG A;  3NZC X;  1RX2 A;  3JTW A;  5HPB A;  3FYV X;  3DRC A;  5U27 A;  3JWF A;  4EIZ A;  3CL9 A;  1JUV A;  3F0V X;  3RO9 A;  5JA3 A;  3N0H A;  4KLX A;  4Q0D A;  1HFR A;  4HOF A;  5HF0 X;  1MVS A;  4NX6 A;  4KY4 A;  4XT5 A;  1E26 A;  4M6L A;  4XT4 A;  5HF2 X;  1M7A A;  4KD7 A;  1KMS A;  1DRE A;  1DYR A;  3SRW X;  1IA1 A;  4G8Z X;  1BOZ A;  5ECC A;  4PTH A;  1PD9 A;  5HQY A;  1U71 A;  3KJR A;  4QLE A;  3DGA A;  3JW3 A;  3QLY A;  3K2H A;  4XE6 X;  3F8Z A;  4P66 A;  4ELB A;  2BLC A;  3F91 A;  3JW5 A;  4KJL A;  2C2S A;  1PD8 A;  5HVE A;  1BZF A;  2W3B A;  1JOL A;  5E8Q A;  1IA2 A;  1DLS A;  3RG9 A;  4H95 A;  2W3A A;  2P4G A;  4X5G A;  1LUD A;  3NXO A;  3CSE A;  1DRB A;  4DPH A;  5JG0 X;  1RA8 A;  7DFR A;  3GHC A;  3FYW X;  1RF7 A;  1RE7 A;  4FGH A;  3KFY A;  1RX5 A;  2GD9 A;  4P3R A;  3EEJ A;  3M09 A;  2ANQ A;  1DIS A;  3GHW A;  3F0X X;  1AI9 A;  1J3K A;  3KJS A;  2LF1 A;  3FQZ A;  4PTJ A;  2CIG A;  3SRS X;  3S9U A;  2HXV A;  4XT7 A;  3IA4 A;  2FZJ A;  1DG5 A;  5HQZ A;  5HI6 A;  3NZA X;  5HSU A;  2D0K A;  4LAE X;  3UM6 A;  1DG8 A;  2HQP A;  2W9H A;  1DRA A;  5CCC A;  4IXF X;  3CD2 A;  4NX7 A;  1RA1 A;  3DAU A;  1D1G A;  1S3U A;  4X5I A;  4X5F A;  1MVT A;  1RA9 A;  3QG2 A;  3ZPC A;  2DRC A;  4HOE A;  4GH8 A;  4KBN A;  4DDR A;  3L3R A;  1U72 A;  4KM0 A;  1RX3 A;  3QLZ A;  1VDR A;  3GYF A;  3OAF A;  1OHK A;  4M7U A;  4OR7 A;  1DR1 A;  3QL3 A;  3SRQ X;  2L28 A;  2C2T A;  4P68 A;  1DIU A;  1IA3 A;  3QYO A;  3EX8 A;  3FY8 X;  3UM8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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