1YHOA

Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
source organism Homo sapiens
publication title Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH.
pubmed doi rcsb
molecule keywords Dihydrofolate reductase
total genus 35
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2005-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1yhoA00
3GI2A 1DR2A 4X5JA 4DP3A 4LAHX 3JW5A 4CD2A 2O7PA 3EIGA 1DRFA 4KLXA 2FZHA 4KJJA 2CD2A 5FDAA 1HFRA 2D0KA 1DR1A 3KFYA 1IA2A 3UM6A 1DHIA 1RX3A 3NXOA 4FHBA 3SA1A 3QYLA 5HT4A 1DR4A 1IA4A 2B3ZA 1J3KA 4PSSA 1DR5A 3DGAA 1U71A 4HA9A 2D5NA 4KL9A 2ZZAA 5ECXA 4HOGA 4Q0EA 3S9UA 4M7UA 3L3RA 3TQ8A 4X5GA 4EJ1A 4KNEA 1RX4A 3DL5A 2AZNA 3ZPGA 2W9SA 1JOLA 1M79A 3SGYA 3UM5A 4PTHA 3EEMA 3CL9A 1PD9A 1JOMA 2JYBA 3JWMA 4Q67A 3KJSA 1DLRA 3HJ3A 4X5FA 3S3VA 3CSEA 1OHKA 4KYAA 3FRFX 4KAKA 3FQVA 2BLCA 1DYRA 3SR5X 3NTZA 5CCCA 1DR3A 2HQPA 3IRMA 3FYVX 1RA9A 3NZBX 3IA4A 1LY4A 1RX8A 3RO9A 3FS6A 3QLSA 1AOEA 3NZ9X 3QLZA 4HOFA 1E26A 4QLEA 1RX5A 3IRNA 2BLAA 1D1GA 6DFRA 2XW7A 4HA7A 1RD7A 4PSTA 1RA2A 4G3MA 1DG5A 2HM9A 2DHFA 1RF7A 3QLWA 1DLSA 3FQZA 3E0BA 1RX1A 2C2TA 2ANQA 3GHWA 5HF2X 3EEJA 1HFQA 4H98A 3OCHA 4ELHA 3FQ0A 1M7AA 5HSRA 1HFPA 1J3IA 1MVSA 4DPDA 2OIPA 3FY8X 3JWFA 4H96A 5U26A 3FRBX 1DG7A 2FZJA 1AI9A 2ANOA 3K45A 1RC4A 1DDSA 7DFRA 4IXGX 5E8QA 3DRCA 2DRCA 1RX6A 3F0UX 4XRBA 4KD7A 3JWKA 2G6VA 3SRWX 3SRRX 1ZDRA 3KJRA 3I3RA 4PDJA 1DHFA 2BLBA 2W9HA 5DFRA 3D84X 3DL6A 1QZFA 4X5IA 1RE7A 5JG0X 4QI9A 2CIGA 4M6LA 2OBCA 3QL0A 4XT7A 3QLRA 5HT5A 2W3WA 2BL9A 1RB3A 3NRRA 1PDBA 1RX9A 1RB2A 4PSYA 5HQYA 1RG7A 5HVEA 1U72A 3TD8A 3EELA 3DFRA 2ITHA 2W9GA 3F8ZA 4QLFA 3TQAA 3FQCA 1DHJA 1BZFA 4P68A 1DISA 3FQFA 4DFRA 3IA5A 4ECKA 3GHVA 4KJLA 1SEJA 3SH2A 3NXRA 4H97A 3R33A 1TDRA 3N0HA 1PD8A 3K74A 4QJCA 4M2XA 3FRAX 4FGHA 1KMSA 4GH8A 1CD2A 1DR7A 1IA3A 3QL3A 4KFJA 3CD2A 3ROAA 3EEKA 4KM2A 3INVA 3F0XX 2FZIA 5HSUA 4X5HA 3CLBA 3JVXA 1J3JA 1DIUA 1M78A 1DG8A 1DRBA 1S3YA 4XE6X 3RG9A 1JUVA 4IXED 3FL8A 1LUDA 5HF0X 3NXXA 3Q1HA 4LAGX 4TU5X 3M09A 3F8YA 3NZCX 2QK8A 4M6JA 4IXFX 3KY8A 1DRAA 1DR6A 2W3MA 3GHCA 3F0SX 3JW3A 4DDRA 1DF7A 4ELGA 4PTJA 5CC9A 1KMVA 3FY9X 5JA3A 4G95A 2C2SA 4EILA 2INQA 3M08A 5ECCA 3I8AX 3FL9A 1RA1A 4I1NA 4KBNA 3JSUA 5HVBA 1VJ3A 1AO8A 4P66A 3NU0A 3F0BX 4RGCA 3NZAX 4EIGA 2GD9A 3FQOA 3FREX 1RA8A 3HBBA 1S3WA 4NX7A 1VDRA 4P3QA 3IX9A 2W3BA 1RX2A 1OHJA 1CZ3A 3F0VX 4Q6AA 1YHOA 3TQ9A 3SA2A 5EAJA 3FYWX 5DXVA 1S3VA 4XT6A 1RH3A 1LY3A 5U27A 5HQZA 4HOEA 2W3AA 3SRQX 4P3RA 4NX6A 3UM8A 2P4GA 1DAJA 3SQYX 2LF1A 1DREA 3LG4A 1IA1A 3SAIA 4FGGA 3DATA 5HI6A 4KM0A 4Q0DA 1DYHA 2HXVA 4KY8A 4LEKX 4XT4A 3FRDX 3NXYA 4M6KA 4OSGA 3DAUA 3IROA 3S7AA 3EX8A 4ELEA 3SRSX 3F0QX 4I13A 3SRUX 4KY4A 4QLGA 3QYOA 4XT5A 3K47A 3ZPCA 4QHVA 4DPHA 3NZ6X 1DDRA 3QFXA 3KGYA 1BOZA 5HPBA 2W9TA 3OAFA 3GYFA 1DYJA 1RA3A 4KEBA 3JWCA 3QG2A 3NXTA 8DFRA 1MVTA 3NZDA 4ELBA 4XT8A 3K2HA 1DRHA 4KJKA 5HUIA 3DG8A 1RX7A 2KGKA 3F91A 3JTWA 3QGTA 4G8ZX 4ELFA 2H2QA 4M7VA 1DYIA 3TQBA 4H95A 3QLYA 2W3VA 3D80A 1S3UA 3NXVA 2L28A 3VCOA 1U70A 4QJZD 4XECX 3QLXA 4OR7A 1KLKA 4EIZA 4LAEX
chains in the Genus database with same CATH superfamily
3GI2A 1DR2A 4X5JA 4DP3A 4LAHX 3JW5A 4CD2A 2O7PA 3EIGA 1DRFA 4KLXA 2FZHA 4KJJA 2CD2A 5FDAA 1HFRA 2D0KA 1DR1A 3KFYA 1IA2A 3UM6A 1DHIA 1RX3A 3NXOA 4FHBA 3SA1A 3QYLA 5HT4A 1DR4A 1IA4A 2B3ZA 1J3KA 4PSSA 1DR5A 3DGAA 1U71A 4HA9A 2D5NA 4KL9A 2ZZAA 5ECXA 4HOGA 4Q0EA 3S9UA 4M7UA 3L3RA 3TQ8A 4X5GA 4EJ1A 4KNEA 1RX4A 3DL5A 2AZNA 3ZPGA 2W9SA 1JOLA 1M79A 3SGYA 3UM5A 4PTHA 3EEMA 3CL9A 1PD9A 1JOMA 2JYBA 3JWMA 4Q67A 3KJSA 1DLRA 3HJ3A 4X5FA 3S3VA 3CSEA 1OHKA 4KYAA 3FRFX 4KAKA 3FQVA 2BLCA 1DYRA 3SR5X 3NTZA 5CCCA 1DR3A 2HQPA 3IRMA 3FYVX 1RA9A 3NZBX 3IA4A 1LY4A 1RX8A 3RO9A 3FS6A 3QLSA 1AOEA 3NZ9X 3QLZA 4HOFA 1E26A 4QLEA 1RX5A 3IRNA 2BLAA 1D1GA 6DFRA 2XW7A 4HA7A 1RD7A 4PSTA 1RA2A 4G3MA 1DG5A 2HM9A 2DHFA 1RF7A 3QLWA 1DLSA 3FQZA 3E0BA 1RX1A 2C2TA 2ANQA 3GHWA 5HF2X 3EEJA 1HFQA 4H98A 3OCHA 4ELHA 3FQ0A 1M7AA 5HSRA 1HFPA 1J3IA 1MVSA 4DPDA 2OIPA 3FY8X 3JWFA 4H96A 5U26A 3FRBX 1DG7A 2FZJA 1AI9A 2ANOA 3K45A 1RC4A 1DDSA 7DFRA 4IXGX 5E8QA 3DRCA 2DRCA 1RX6A 3F0UX 4XRBA 4KD7A 3JWKA 2G6VA 3SRWX 3SRRX 1ZDRA 3KJRA 3I3RA 4PDJA 1DHFA 2BLBA 2W9HA 5DFRA 3D84X 3DL6A 1QZFA 4X5IA 1RE7A 5JG0X 4QI9A 2CIGA 4M6LA 2OBCA 3QL0A 4XT7A 3QLRA 5HT5A 2W3WA 2BL9A 1RB3A 3NRRA 1PDBA 1RX9A 1RB2A 4PSYA 5HQYA 1RG7A 5HVEA 1U72A 3TD8A 3EELA 3DFRA 2ITHA 2W9GA 3F8ZA 4QLFA 3TQAA 3FQCA 1DHJA 1BZFA 4P68A 1DISA 3FQFA 4DFRA 3IA5A 4ECKA 3GHVA 4KJLA 1SEJA 3SH2A 3NXRA 4H97A 3R33A 1TDRA 3N0HA 1PD8A 3K74A 4QJCA 4M2XA 3FRAX 4FGHA 1KMSA 4GH8A 1CD2A 1DR7A 1IA3A 3QL3A 4KFJA 3CD2A 3ROAA 3EEKA 4KM2A 3INVA 3F0XX 2FZIA 5HSUA 4X5HA 3CLBA 3JVXA 1J3JA 1DIUA 1M78A 1DG8A 1DRBA 1S3YA 4XE6X 3RG9A 1JUVA 4IXED 3FL8A 1LUDA 5HF0X 3NXXA 3Q1HA 4LAGX 4TU5X 3M09A 3F8YA 3NZCX 2QK8A 4M6JA 4IXFX 3KY8A 1DRAA 1DR6A 2W3MA 3GHCA 3F0SX 3JW3A 4DDRA 1DF7A 4ELGA 4PTJA 5CC9A 1KMVA 3FY9X 5JA3A 4G95A 2C2SA 4EILA 2INQA 3M08A 5ECCA 3I8AX 3FL9A 1RA1A 4I1NA 4KBNA 3JSUA 5HVBA 1VJ3A 1AO8A 4P66A 3NU0A 3F0BX 4RGCA 3NZAX 4EIGA 2GD9A 3FQOA 3FREX 1RA8A 3HBBA 1S3WA 4NX7A 1VDRA 4P3QA 3IX9A 2W3BA 1RX2A 1OHJA 1CZ3A 3F0VX 4Q6AA 1YHOA 3TQ9A 3SA2A 5EAJA 3FYWX 5DXVA 1S3VA 4XT6A 1RH3A 1LY3A 5U27A 5HQZA 4HOEA 2W3AA 3SRQX 4P3RA 4NX6A 3UM8A 2P4GA 1DAJA 3SQYX 2LF1A 1DREA 3LG4A 1IA1A 3SAIA 4FGGA 3DATA 5HI6A 4KM0A 4Q0DA 1DYHA 2HXVA 4KY8A 4LEKX 4XT4A 3FRDX 3NXYA 4M6KA 4OSGA 3DAUA 3IROA 3S7AA 3EX8A 4ELEA 3SRSX 3F0QX 4I13A 3SRUX 4KY4A 4QLGA 3QYOA 4XT5A 3K47A 3ZPCA 4QHVA 4DPHA 3NZ6X 1DDRA 3QFXA 3KGYA 1BOZA 5HPBA 2W9TA 3OAFA 3GYFA 1DYJA 1RA3A 4KEBA 3JWCA 3QG2A 3NXTA 8DFRA 1MVTA 3NZDA 4ELBA 4XT8A 3K2HA 1DRHA 4KJKA 5HUIA 3DG8A 1RX7A 2KGKA 3F91A 3JTWA 3QGTA 4G8ZX 4ELFA 2H2QA 4M7VA 1DYIA 3TQBA 4H95A 3QLYA 2W3VA 3D80A 1S3UA 3NXVA 2L28A 3VCOA 1U70A 4QJZD 4XECX 3QLXA 4OR7A 1KLKA 4EIZA 4LAEX
chains in the Genus database with same CATH topology
3GI2A 1DR2A 4X5JA 4DP3A 4LAHX 3JW5A 4CD2A 2O7PA 3EIGA 1DRFA 4KLXA 2FZHA 4KJJA 2CD2A 5FDAA 1HFRA 2D0KA 1DR1A 3KFYA 1IA2A 3UM6A 1DHIA 1RX3A 3NXOA 4FHBA 3SA1A 3QYLA 5HT4A 1DR4A 1IA4A 2B3ZA 1J3KA 4PSSA 1DR5A 3DGAA 1U71A 4HA9A 2D5NA 4KL9A 2ZZAA 5ECXA 4HOGA 4Q0EA 3S9UA 4M7UA 3L3RA 3TQ8A 4X5GA 4EJ1A 4KNEA 1RX4A 3DL5A 2AZNA 3ZPGA 2W9SA 1JOLA 1M79A 3SGYA 3UM5A 4PTHA 3EEMA 3CL9A 1PD9A 1JOMA 2JYBA 3JWMA 4Q67A 3KJSA 1DLRA 3HJ3A 4X5FA 3S3VA 3CSEA 1OHKA 4KYAA 3FRFX 4KAKA 3FQVA 2BLCA 1DYRA 3SR5X 3NTZA 5CCCA 1DR3A 2HQPA 3IRMA 3FYVX 1RA9A 3NZBX 3IA4A 1LY4A 1RX8A 3RO9A 3FS6A 3QLSA 1AOEA 3NZ9X 3QLZA 4HOFA 1E26A 4QLEA 1RX5A 3IRNA 2BLAA 1D1GA 6DFRA 2XW7A 4HA7A 1RD7A 4PSTA 1RA2A 4G3MA 1DG5A 2HM9A 2DHFA 1RF7A 3QLWA 1DLSA 3FQZA 3E0BA 1RX1A 2C2TA 2ANQA 3GHWA 5HF2X 3EEJA 1HFQA 4H98A 3OCHA 4ELHA 3FQ0A 1M7AA 5HSRA 1HFPA 1J3IA 1MVSA 4DPDA 2OIPA 3FY8X 3JWFA 4H96A 5U26A 3FRBX 1DG7A 2FZJA 1AI9A 2ANOA 3K45A 1RC4A 1DDSA 7DFRA 4IXGX 5E8QA 3DRCA 2DRCA 1RX6A 3F0UX 4XRBA 4KD7A 3JWKA 2G6VA 3SRWX 3SRRX 1ZDRA 3KJRA 3I3RA 4PDJA 1DHFA 2BLBA 2W9HA 5DFRA 3D84X 3DL6A 1QZFA 4X5IA 1RE7A 5JG0X 4QI9A 2CIGA 4M6LA 2OBCA 3QL0A 4XT7A 3QLRA 5HT5A 2W3WA 2BL9A 1RB3A 3NRRA 1PDBA 1RX9A 1RB2A 4PSYA 5HQYA 1RG7A 5HVEA 1U72A 3TD8A 3EELA 3DFRA 2ITHA 2W9GA 3F8ZA 4QLFA 3TQAA 3FQCA 1DHJA 1BZFA 4P68A 1DISA 3FQFA 4DFRA 3IA5A 4ECKA 3GHVA 4KJLA 1SEJA 3SH2A 3NXRA 4H97A 3R33A 1TDRA 3N0HA 1PD8A 3K74A 4QJCA 4M2XA 3FRAX 4FGHA 1KMSA 4GH8A 1CD2A 1DR7A 1IA3A 3QL3A 4KFJA 3CD2A 3ROAA 3EEKA 4KM2A 3INVA 3F0XX 2FZIA 5HSUA 4X5HA 3CLBA 3JVXA 1J3JA 1DIUA 1M78A 1DG8A 1DRBA 1S3YA 4XE6X 3RG9A 1JUVA 4IXED 3FL8A 1LUDA 5HF0X 3NXXA 3Q1HA 4LAGX 4TU5X 3M09A 3F8YA 3NZCX 2QK8A 4M6JA 4IXFX 3KY8A 1DRAA 1DR6A 2W3MA 3GHCA 3F0SX 3JW3A 4DDRA 1DF7A 4ELGA 4PTJA 5CC9A 1KMVA 3FY9X 5JA3A 4G95A 2C2SA 4EILA 2INQA 3M08A 5ECCA 3I8AX 3FL9A 1RA1A 4I1NA 4KBNA 3JSUA 5HVBA 1VJ3A 1AO8A 4P66A 3NU0A 3F0BX 4RGCA 3NZAX 4EIGA 2GD9A 3FQOA 3FREX 1RA8A 3HBBA 1S3WA 4NX7A 1VDRA 4P3QA 3IX9A 2W3BA 1RX2A 1OHJA 1CZ3A 3F0VX 4Q6AA 1YHOA 3TQ9A 3SA2A 5EAJA 3FYWX 5DXVA 1S3VA 4XT6A 1RH3A 1LY3A 5U27A 5HQZA 4HOEA 2W3AA 3SRQX 4P3RA 4NX6A 3UM8A 2P4GA 1DAJA 3SQYX 2LF1A 1DREA 3LG4A 1IA1A 3SAIA 4FGGA 3DATA 5HI6A 4KM0A 4Q0DA 1DYHA 2HXVA 4KY8A 4LEKX 4XT4A 3FRDX 3NXYA 4M6KA 4OSGA 3DAUA 3IROA 3S7AA 3EX8A 4ELEA 3SRSX 3F0QX 4I13A 3SRUX 4KY4A 4QLGA 3QYOA 4XT5A 3K47A 3ZPCA 4QHVA 4DPHA 3NZ6X 1DDRA 3QFXA 3KGYA 1BOZA 5HPBA 2W9TA 3OAFA 3GYFA 1DYJA 1RA3A 4KEBA 3JWCA 3QG2A 3NXTA 8DFRA 1MVTA 3NZDA 4ELBA 4XT8A 3K2HA 1DRHA 4KJKA 5HUIA 3DG8A 1RX7A 2KGKA 3F91A 3JTWA 3QGTA 4G8ZX 4ELFA 2H2QA 4M7VA 1DYIA 3TQBA 4H95A 3QLYA 2W3VA 3D80A 1S3UA 3NXVA 2L28A 3VCOA 1U70A 4QJZD 4XECX 3QLXA 4OR7A 1KLKA 4EIZA 4LAEX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GI2 A;  1DR2 A;  4X5J A;  4DP3 A;  4LAH X;  3JW5 A;  4CD2 A;  2O7P A;  3EIG A;  1DRF A;  4KLX A;  2FZH A;  4KJJ A;  2CD2 A;  5FDA A;  1HFR A;  2D0K A;  1DR1 A;  3KFY A;  1IA2 A;  3UM6 A;  1DHI A;  1RX3 A;  3NXO A;  4FHB A;  3SA1 A;  3QYL A;  5HT4 A;  1DR4 A;  1IA4 A;  2B3Z A;  1J3K A;  4PSS A;  1DR5 A;  3DGA A;  1U71 A;  4HA9 A;  2D5N A;  4KL9 A;  2ZZA A;  5ECX A;  4HOG A;  4Q0E A;  3S9U A;  4M7U A;  3L3R A;  3TQ8 A;  4X5G A;  4EJ1 A;  4KNE A;  1RX4 A;  3DL5 A;  2AZN A;  3ZPG A;  2W9S A;  1JOL A;  1M79 A;  3SGY A;  3UM5 A;  4PTH A;  3EEM A;  3CL9 A;  1PD9 A;  1JOM A;  2JYB A;  3JWM A;  4Q67 A;  3KJS A;  1DLR A;  3HJ3 A;  4X5F A;  3S3V A;  3CSE A;  1OHK A;  4KYA A;  3FRF X;  4KAK A;  3FQV A;  2BLC A;  1DYR A;  3SR5 X;  3NTZ A;  5CCC A;  1DR3 A;  2HQP A;  3IRM A;  3FYV X;  1RA9 A;  3NZB X;  3IA4 A;  1LY4 A;  1RX8 A;  3RO9 A;  3FS6 A;  3QLS A;  1AOE A;  3NZ9 X;  3QLZ A;  4HOF A;  1E26 A;  4QLE A;  1RX5 A;  3IRN A;  2BLA A;  1D1G A;  6DFR A;  2XW7 A;  4HA7 A;  1RD7 A;  4PST A;  1RA2 A;  4G3M A;  1DG5 A;  2HM9 A;  2DHF A;  1RF7 A;  3QLW A;  1DLS A;  3FQZ A;  3E0B A;  1RX1 A;  2C2T A;  2ANQ A;  3GHW A;  5HF2 X;  3EEJ A;  1HFQ A;  4H98 A;  3OCH A;  4ELH A;  3FQ0 A;  1M7A A;  5HSR A;  1HFP A;  1J3I A;  1MVS A;  4DPD A;  2OIP A;  3FY8 X;  3JWF A;  4H96 A;  5U26 A;  3FRB X;  1DG7 A;  2FZJ A;  1AI9 A;  2ANO A;  3K45 A;  1RC4 A;  1DDS A;  7DFR A;  4IXG X;  5E8Q A;  3DRC A;  2DRC A;  1RX6 A;  3F0U X;  4XRB A;  4KD7 A;  3JWK A;  2G6V A;  3SRW X;  3SRR X;  1ZDR A;  3KJR A;  3I3R A;  4PDJ A;  1DHF A;  2BLB A;  2W9H A;  5DFR A;  3D84 X;  3DL6 A;  1QZF A;  4X5I A;  1RE7 A;  5JG0 X;  4QI9 A;  2CIG A;  4M6L A;  2OBC A;  3QL0 A;  4XT7 A;  3QLR A;  5HT5 A;  2W3W A;  2BL9 A;  1RB3 A;  3NRR A;  1PDB A;  1RX9 A;  1RB2 A;  4PSY A;  5HQY A;  1RG7 A;  5HVE A;  1U72 A;  3TD8 A;  3EEL A;  3DFR A;  2ITH A;  2W9G A;  3F8Z A;  4QLF A;  3TQA A;  3FQC A;  1DHJ A;  1BZF A;  4P68 A;  1DIS A;  3FQF A;  4DFR A;  3IA5 A;  4ECK A;  3GHV A;  4KJL A;  1SEJ A;  3SH2 A;  3NXR A;  4H97 A;  3R33 A;  1TDR A;  3N0H A;  1PD8 A;  3K74 A;  4QJC A;  4M2X A;  3FRA X;  4FGH A;  1KMS A;  4GH8 A;  1CD2 A;  1DR7 A;  1IA3 A;  3QL3 A;  4KFJ A;  3CD2 A;  3ROA A;  3EEK A;  4KM2 A;  3INV A;  3F0X X;  2FZI A;  5HSU A;  4X5H A;  3CLB A;  3JVX A;  1J3J A;  1DIU A;  1M78 A;  1DG8 A;  1DRB A;  1S3Y A;  4XE6 X;  3RG9 A;  1JUV A;  4IXE D;  3FL8 A;  1LUD A;  5HF0 X;  3NXX A;  3Q1H A;  4LAG X;  4TU5 X;  3M09 A;  3F8Y A;  3NZC X;  2QK8 A;  4M6J A;  4IXF X;  3KY8 A;  1DRA A;  1DR6 A;  2W3M A;  3GHC A;  3F0S X;  3JW3 A;  4DDR A;  1DF7 A;  4ELG A;  4PTJ A;  5CC9 A;  1KMV A;  3FY9 X;  5JA3 A;  4G95 A;  2C2S A;  4EIL A;  2INQ A;  3M08 A;  5ECC A;  3I8A X;  3FL9 A;  1RA1 A;  4I1N A;  4KBN A;  3JSU A;  5HVB A;  1VJ3 A;  1AO8 A;  4P66 A;  3NU0 A;  3F0B X;  4RGC A;  3NZA X;  4EIG A;  2GD9 A;  3FQO A;  3FRE X;  1RA8 A;  3HBB A;  1S3W A;  4NX7 A;  1VDR A;  4P3Q A;  3IX9 A;  2W3B A;  1RX2 A;  1OHJ A;  1CZ3 A;  3F0V X;  4Q6A A;  1YHO A;  3TQ9 A;  3SA2 A;  5EAJ A;  3FYW X;  5DXV A;  1S3V A;  4XT6 A;  1RH3 A;  1LY3 A;  5U27 A;  5HQZ A;  4HOE A;  2W3A A;  3SRQ X;  4P3R A;  4NX6 A;  3UM8 A;  2P4G A;  1DAJ A;  3SQY X;  2LF1 A;  1DRE A;  3LG4 A;  1IA1 A;  3SAI A;  4FGG A;  3DAT A;  5HI6 A;  4KM0 A;  4Q0D A;  1DYH A;  2HXV A;  4KY8 A;  4LEK X;  4XT4 A;  3FRD X;  3NXY A;  4M6K A;  4OSG A;  3DAU A;  3IRO A;  3S7A A;  3EX8 A;  4ELE A;  3SRS X;  3F0Q X;  4I13 A;  3SRU X;  4KY4 A;  4QLG A;  3QYO A;  4XT5 A;  3K47 A;  3ZPC A;  4QHV A;  4DPH A;  3NZ6 X;  1DDR A;  3QFX A;  3KGY A;  1BOZ A;  5HPB A;  2W9T A;  3OAF A;  3GYF A;  1DYJ A;  1RA3 A;  4KEB A;  3JWC A;  3QG2 A;  3NXT A;  8DFR A;  1MVT A;  3NZD A;  4ELB A;  4XT8 A;  3K2H A;  1DRH A;  4KJK A;  5HUI A;  3DG8 A;  1RX7 A;  2KGK A;  3F91 A;  3JTW A;  3QGT A;  4G8Z X;  4ELF A;  2H2Q A;  4M7V A;  1DYI A;  3TQB A;  4H95 A;  3QLY A;  2W3V A;  3D80 A;  1S3U A;  3NXV A;  2L28 A;  3VCO A;  1U70 A;  4QJZ D;  4XEC X;  3QLX A;  4OR7 A;  1KLK A;  4EIZ A;  4LAE X; 
#chains in the Genus database with same CATH topology
 3GI2 A;  1DR2 A;  4X5J A;  4DP3 A;  4LAH X;  3JW5 A;  4CD2 A;  2O7P A;  3EIG A;  1DRF A;  4KLX A;  2FZH A;  4KJJ A;  2CD2 A;  5FDA A;  1HFR A;  2D0K A;  1DR1 A;  3KFY A;  1IA2 A;  3UM6 A;  1DHI A;  1RX3 A;  3NXO A;  4FHB A;  3SA1 A;  3QYL A;  5HT4 A;  1DR4 A;  1IA4 A;  2B3Z A;  1J3K A;  4PSS A;  1DR5 A;  3DGA A;  1U71 A;  4HA9 A;  2D5N A;  4KL9 A;  2ZZA A;  5ECX A;  4HOG A;  4Q0E A;  3S9U A;  4M7U A;  3L3R A;  3TQ8 A;  4X5G A;  4EJ1 A;  4KNE A;  1RX4 A;  3DL5 A;  2AZN A;  3ZPG A;  2W9S A;  1JOL A;  1M79 A;  3SGY A;  3UM5 A;  4PTH A;  3EEM A;  3CL9 A;  1PD9 A;  1JOM A;  2JYB A;  3JWM A;  4Q67 A;  3KJS A;  1DLR A;  3HJ3 A;  4X5F A;  3S3V A;  3CSE A;  1OHK A;  4KYA A;  3FRF X;  4KAK A;  3FQV A;  2BLC A;  1DYR A;  3SR5 X;  3NTZ A;  5CCC A;  1DR3 A;  2HQP A;  3IRM A;  3FYV X;  1RA9 A;  3NZB X;  3IA4 A;  1LY4 A;  1RX8 A;  3RO9 A;  3FS6 A;  3QLS A;  1AOE A;  3NZ9 X;  3QLZ A;  4HOF A;  1E26 A;  4QLE A;  1RX5 A;  3IRN A;  2BLA A;  1D1G A;  6DFR A;  2XW7 A;  4HA7 A;  1RD7 A;  4PST A;  1RA2 A;  4G3M A;  1DG5 A;  2HM9 A;  2DHF A;  1RF7 A;  3QLW A;  1DLS A;  3FQZ A;  3E0B A;  1RX1 A;  2C2T A;  2ANQ A;  3GHW A;  5HF2 X;  3EEJ A;  1HFQ A;  4H98 A;  3OCH A;  4ELH A;  3FQ0 A;  1M7A A;  5HSR A;  1HFP A;  1J3I A;  1MVS A;  4DPD A;  2OIP A;  3FY8 X;  3JWF A;  4H96 A;  5U26 A;  3FRB X;  1DG7 A;  2FZJ A;  1AI9 A;  2ANO A;  3K45 A;  1RC4 A;  1DDS A;  7DFR A;  4IXG X;  5E8Q A;  3DRC A;  2DRC A;  1RX6 A;  3F0U X;  4XRB A;  4KD7 A;  3JWK A;  2G6V A;  3SRW X;  3SRR X;  1ZDR A;  3KJR A;  3I3R A;  4PDJ A;  1DHF A;  2BLB A;  2W9H A;  5DFR A;  3D84 X;  3DL6 A;  1QZF A;  4X5I A;  1RE7 A;  5JG0 X;  4QI9 A;  2CIG A;  4M6L A;  2OBC A;  3QL0 A;  4XT7 A;  3QLR A;  5HT5 A;  2W3W A;  2BL9 A;  1RB3 A;  3NRR A;  1PDB A;  1RX9 A;  1RB2 A;  4PSY A;  5HQY A;  1RG7 A;  5HVE A;  1U72 A;  3TD8 A;  3EEL A;  3DFR A;  2ITH A;  2W9G A;  3F8Z A;  4QLF A;  3TQA A;  3FQC A;  1DHJ A;  1BZF A;  4P68 A;  1DIS A;  3FQF A;  4DFR A;  3IA5 A;  4ECK A;  3GHV A;  4KJL A;  1SEJ A;  3SH2 A;  3NXR A;  4H97 A;  3R33 A;  1TDR A;  3N0H A;  1PD8 A;  3K74 A;  4QJC A;  4M2X A;  3FRA X;  4FGH A;  1KMS A;  4GH8 A;  1CD2 A;  1DR7 A;  1IA3 A;  3QL3 A;  4KFJ A;  3CD2 A;  3ROA A;  3EEK A;  4KM2 A;  3INV A;  3F0X X;  2FZI A;  5HSU A;  4X5H A;  3CLB A;  3JVX A;  1J3J A;  1DIU A;  1M78 A;  1DG8 A;  1DRB A;  1S3Y A;  4XE6 X;  3RG9 A;  1JUV A;  4IXE D;  3FL8 A;  1LUD A;  5HF0 X;  3NXX A;  3Q1H A;  4LAG X;  4TU5 X;  3M09 A;  3F8Y A;  3NZC X;  2QK8 A;  4M6J A;  4IXF X;  3KY8 A;  1DRA A;  1DR6 A;  2W3M A;  3GHC A;  3F0S X;  3JW3 A;  4DDR A;  1DF7 A;  4ELG A;  4PTJ A;  5CC9 A;  1KMV A;  3FY9 X;  5JA3 A;  4G95 A;  2C2S A;  4EIL A;  2INQ A;  3M08 A;  5ECC A;  3I8A X;  3FL9 A;  1RA1 A;  4I1N A;  4KBN A;  3JSU A;  5HVB A;  1VJ3 A;  1AO8 A;  4P66 A;  3NU0 A;  3F0B X;  4RGC A;  3NZA X;  4EIG A;  2GD9 A;  3FQO A;  3FRE X;  1RA8 A;  3HBB A;  1S3W A;  4NX7 A;  1VDR A;  4P3Q A;  3IX9 A;  2W3B A;  1RX2 A;  1OHJ A;  1CZ3 A;  3F0V X;  4Q6A A;  1YHO A;  3TQ9 A;  3SA2 A;  5EAJ A;  3FYW X;  5DXV A;  1S3V A;  4XT6 A;  1RH3 A;  1LY3 A;  5U27 A;  5HQZ A;  4HOE A;  2W3A A;  3SRQ X;  4P3R A;  4NX6 A;  3UM8 A;  2P4G A;  1DAJ A;  3SQY X;  2LF1 A;  1DRE A;  3LG4 A;  1IA1 A;  3SAI A;  4FGG A;  3DAT A;  5HI6 A;  4KM0 A;  4Q0D A;  1DYH A;  2HXV A;  4KY8 A;  4LEK X;  4XT4 A;  3FRD X;  3NXY A;  4M6K A;  4OSG A;  3DAU A;  3IRO A;  3S7A A;  3EX8 A;  4ELE A;  3SRS X;  3F0Q X;  4I13 A;  3SRU X;  4KY4 A;  4QLG A;  3QYO A;  4XT5 A;  3K47 A;  3ZPC A;  4QHV A;  4DPH A;  3NZ6 X;  1DDR A;  3QFX A;  3KGY A;  1BOZ A;  5HPB A;  2W9T A;  3OAF A;  3GYF A;  1DYJ A;  1RA3 A;  4KEB A;  3JWC A;  3QG2 A;  3NXT A;  8DFR A;  1MVT A;  3NZD A;  4ELB A;  4XT8 A;  3K2H A;  1DRH A;  4KJK A;  5HUI A;  3DG8 A;  1RX7 A;  2KGK A;  3F91 A;  3JTW A;  3QGT A;  4G8Z X;  4ELF A;  2H2Q A;  4M7V A;  1DYI A;  3TQB A;  4H95 A;  3QLY A;  2W3V A;  3D80 A;  1S3U A;  3NXV A;  2L28 A;  3VCO A;  1U70 A;  4QJZ D;  4XEC X;  3QLX A;  4OR7 A;  1KLK A;  4EIZ A;  4LAE X; 
#chains in the Genus database with same CATH homology
 3GI2 A;  1DR2 A;  4X5J A;  4DP3 A;  4LAH X;  3JW5 A;  4CD2 A;  2O7P A;  3EIG A;  1DRF A;  4KLX A;  2FZH A;  4KJJ A;  2CD2 A;  5FDA A;  1HFR A;  2D0K A;  1DR1 A;  3KFY A;  1IA2 A;  3UM6 A;  1DHI A;  1RX3 A;  3NXO A;  4FHB A;  3SA1 A;  3QYL A;  5HT4 A;  1DR4 A;  1IA4 A;  2B3Z A;  1J3K A;  4PSS A;  1DR5 A;  3DGA A;  1U71 A;  4HA9 A;  2D5N A;  4KL9 A;  2ZZA A;  5ECX A;  4HOG A;  4Q0E A;  3S9U A;  4M7U A;  3L3R A;  3TQ8 A;  4X5G A;  4EJ1 A;  4KNE A;  1RX4 A;  3DL5 A;  2AZN A;  3ZPG A;  2W9S A;  1JOL A;  1M79 A;  3SGY A;  3UM5 A;  4PTH A;  3EEM A;  3CL9 A;  1PD9 A;  1JOM A;  2JYB A;  3JWM A;  4Q67 A;  3KJS A;  1DLR A;  3HJ3 A;  4X5F A;  3S3V A;  3CSE A;  1OHK A;  4KYA A;  3FRF X;  4KAK A;  3FQV A;  2BLC A;  1DYR A;  3SR5 X;  3NTZ A;  5CCC A;  1DR3 A;  2HQP A;  3IRM A;  3FYV X;  1RA9 A;  3NZB X;  3IA4 A;  1LY4 A;  1RX8 A;  3RO9 A;  3FS6 A;  3QLS A;  1AOE A;  3NZ9 X;  3QLZ A;  4HOF A;  1E26 A;  4QLE A;  1RX5 A;  3IRN A;  2BLA A;  1D1G A;  6DFR A;  2XW7 A;  4HA7 A;  1RD7 A;  4PST A;  1RA2 A;  4G3M A;  1DG5 A;  2HM9 A;  2DHF A;  1RF7 A;  3QLW A;  1DLS A;  3FQZ A;  3E0B A;  1RX1 A;  2C2T A;  2ANQ A;  3GHW A;  5HF2 X;  3EEJ A;  1HFQ A;  4H98 A;  3OCH A;  4ELH A;  3FQ0 A;  1M7A A;  5HSR A;  1HFP A;  1J3I A;  1MVS A;  4DPD A;  2OIP A;  3FY8 X;  3JWF A;  4H96 A;  5U26 A;  3FRB X;  1DG7 A;  2FZJ A;  1AI9 A;  2ANO A;  3K45 A;  1RC4 A;  1DDS A;  7DFR A;  4IXG X;  5E8Q A;  3DRC A;  2DRC A;  1RX6 A;  3F0U X;  4XRB A;  4KD7 A;  3JWK A;  2G6V A;  3SRW X;  3SRR X;  1ZDR A;  3KJR A;  3I3R A;  4PDJ A;  1DHF A;  2BLB A;  2W9H A;  5DFR A;  3D84 X;  3DL6 A;  1QZF A;  4X5I A;  1RE7 A;  5JG0 X;  4QI9 A;  2CIG A;  4M6L A;  2OBC A;  3QL0 A;  4XT7 A;  3QLR A;  5HT5 A;  2W3W A;  2BL9 A;  1RB3 A;  3NRR A;  1PDB A;  1RX9 A;  1RB2 A;  4PSY A;  5HQY A;  1RG7 A;  5HVE A;  1U72 A;  3TD8 A;  3EEL A;  3DFR A;  2ITH A;  2W9G A;  3F8Z A;  4QLF A;  3TQA A;  3FQC A;  1DHJ A;  1BZF A;  4P68 A;  1DIS A;  3FQF A;  4DFR A;  3IA5 A;  4ECK A;  3GHV A;  4KJL A;  1SEJ A;  3SH2 A;  3NXR A;  4H97 A;  3R33 A;  1TDR A;  3N0H A;  1PD8 A;  3K74 A;  4QJC A;  4M2X A;  3FRA X;  4FGH A;  1KMS A;  4GH8 A;  1CD2 A;  1DR7 A;  1IA3 A;  3QL3 A;  4KFJ A;  3CD2 A;  3ROA A;  3EEK A;  4KM2 A;  3INV A;  3F0X X;  2FZI A;  5HSU A;  4X5H A;  3CLB A;  3JVX A;  1J3J A;  1DIU A;  1M78 A;  1DG8 A;  1DRB A;  1S3Y A;  4XE6 X;  3RG9 A;  1JUV A;  4IXE D;  3FL8 A;  1LUD A;  5HF0 X;  3NXX A;  3Q1H A;  4LAG X;  4TU5 X;  3M09 A;  3F8Y A;  3NZC X;  2QK8 A;  4M6J A;  4IXF X;  3KY8 A;  1DRA A;  1DR6 A;  2W3M A;  3GHC A;  3F0S X;  3JW3 A;  4DDR A;  1DF7 A;  4ELG A;  4PTJ A;  5CC9 A;  1KMV A;  3FY9 X;  5JA3 A;  4G95 A;  2C2S A;  4EIL A;  2INQ A;  3M08 A;  5ECC A;  3I8A X;  3FL9 A;  1RA1 A;  4I1N A;  4KBN A;  3JSU A;  5HVB A;  1VJ3 A;  1AO8 A;  4P66 A;  3NU0 A;  3F0B X;  4RGC A;  3NZA X;  4EIG A;  2GD9 A;  3FQO A;  3FRE X;  1RA8 A;  3HBB A;  1S3W A;  4NX7 A;  1VDR A;  4P3Q A;  3IX9 A;  2W3B A;  1RX2 A;  1OHJ A;  1CZ3 A;  3F0V X;  4Q6A A;  1YHO A;  3TQ9 A;  3SA2 A;  5EAJ A;  3FYW X;  5DXV A;  1S3V A;  4XT6 A;  1RH3 A;  1LY3 A;  5U27 A;  5HQZ A;  4HOE A;  2W3A A;  3SRQ X;  4P3R A;  4NX6 A;  3UM8 A;  2P4G A;  1DAJ A;  3SQY X;  2LF1 A;  1DRE A;  3LG4 A;  1IA1 A;  3SAI A;  4FGG A;  3DAT A;  5HI6 A;  4KM0 A;  4Q0D A;  1DYH A;  2HXV A;  4KY8 A;  4LEK X;  4XT4 A;  3FRD X;  3NXY A;  4M6K A;  4OSG A;  3DAU A;  3IRO A;  3S7A A;  3EX8 A;  4ELE A;  3SRS X;  3F0Q X;  4I13 A;  3SRU X;  4KY4 A;  4QLG A;  3QYO A;  4XT5 A;  3K47 A;  3ZPC A;  4QHV A;  4DPH A;  3NZ6 X;  1DDR A;  3QFX A;  3KGY A;  1BOZ A;  5HPB A;  2W9T A;  3OAF A;  3GYF A;  1DYJ A;  1RA3 A;  4KEB A;  3JWC A;  3QG2 A;  3NXT A;  8DFR A;  1MVT A;  3NZD A;  4ELB A;  4XT8 A;  3K2H A;  1DRH A;  4KJK A;  5HUI A;  3DG8 A;  1RX7 A;  2KGK A;  3F91 A;  3JTW A;  3QGT A;  4G8Z X;  4ELF A;  2H2Q A;  4M7V A;  1DYI A;  3TQB A;  4H95 A;  3QLY A;  2W3V A;  3D80 A;  1S3U A;  3NXV A;  2L28 A;  3VCO A;  1U70 A;  4QJZ D;  4XEC X;  3QLX A;  4OR7 A;  1KLK A;  4EIZ A;  4LAE X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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