1DG7A

Dihydrofolate reductase of mycobacterium tuberculosis complexed with nadph and 4-bromo wr99210
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
159
structure length
159
Chain Sequence
MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 42
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1999-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1dg7A00
3FRBX 3NXRA 4Q6AA 3M09A 2BLCA 3E0BA 1J3IA 3EEKA 4G95A 4QJCA 3HBBA 1RB2A 1DDRA 3NXTA 4M6JA 5DXVA 4DP3A 4ECKA 4PSSA 3F0SX 4FGHA 4KJLA 4H98A 4M2XA 1DRAA 2W3VA 4X5GA 2D5NA 3SQYX 1CD2A 1DR2A 1DR5A 2ANQA 1DLRA 1BOZA 1DRBA 3KJRA 5JG0X 3FY8X 4HOEA 3NZDA 4KNEA 2HM9A 1TDRA 3DGAA 2G6VA 4KY4A 3ZPCA 3SRQX 3JVXA 5EAJA 1HFPA 3QLXA 3IX9A 3IA5A 4IXGX 1E26A 4CD2A 1VDRA 3GHVA 1M78A 3K45A 2W3AA 1DG8A 5HQYA 3EIGA 3IROA 3JSUA 3K47A 3SH2A 3HJ3A 1RA8A 3DL5A 4EJ1A 3L3RA 1DLSA 2AZNA 3FQVA 5HVEA 1S3YA 3FREX 2QK8A 4DPDA 2DRCA 4NX7A 1RX8A 2FZHA 3NU0A 5HT5A 4LAGX 1JOMA 3K74A 1DAJA 1PD8A 5FDAA 4P3RA 4EIGA 4GH8A 3INVA 3F8YA 3GI2A 4QLEA 4PTHA 3EEJA 1DYHA 3F0UX 3QG2A 1RX4A 1RX3A 2B3ZA 3NZBX 3TQBA 4QHVA 4EILA 1IA4A 2ANOA 3FYVX 4HA7A 5HSUA 4IXFX 5CC9A 1ZDRA 1J3KA 1DYIA 3OCHA 4X5JA 4PSYA 3JW5A 3NXYA 3F0QX 1DHFA 1RX5A 1DR1A 4KM2A 3NRRA 4M7VA 2C2TA 3TD8A 2H2QA 3SAIA 5CCCA 1OHJA 4OSGA 3SRSX 4P68A 3UM8A 1QZFA 3QFXA 4DFRA 3CD2A 1AO8A 4RGCA 2P4GA 3NXVA 4KBNA 3FS6A 1RX1A 4X5HA 1VJ3A 4G3MA 3TQ9A 1RG7A 3F0XX 4P3QA 1DG5A 3CLBA 4XT5A 3JWFA 2GD9A 3KGYA 1U71A 2D0KA 3DRCA 3D80A 3Q1HA 4ELFA 3NZ6X 5HF0X 2OBCA 4I1NA 3OAFA 4XT7A 3D84X 3DFRA 4PDJA 3N0HA 3TQ8A 2O7PA 3RG9A 4DPHA 4X5FA 3SGYA 4NX6A 3DG8A 3FQOA 1J3JA 4IXED 1RA2A 3NXOA 4HOGA 4KLXA 8DFRA 3QLWA 4ELEA 3JWMA 3EEMA 3EELA 1RX9A 2BL9A 5E8QA 3S9UA 3FQ0A 3FQZA 4KYAA 1DF7A 1CZ3A 4HA9A 1JOLA 4LAHX 4I13A 1HFQA 5HUIA 4QI9A 3FY9X 1DR6A 4KM0A 1DYJA 4XT6A 1D1GA 4XECX 4P66A 3SRWX 4QLGA 4OR7A 4X5IA 5HF2X 3IRNA 1DRHA 3NZCX 3QL0A 4G8ZX 4KEBA 3FYWX 3SA2A 2DHFA 2L28A 4KY8A 3I3RA 1JUVA 3FL8A 4LEKX 2INQA 1S3WA 5U27A 2OIPA 1RD7A 1DR3A 1U72A 3F91A 3S3VA 1MVSA 1DG7A 4LAEX 3KFYA 2W3BA 4XE6X 3DAUA 3M08A 3QLRA 1IA2A 3ROAA 1PD9A 3JWKA 3QGTA 2HXVA 5ECCA 1MVTA 4HOFA 3QYLA 3JTWA 3NZAX 3JW3A 5JA3A 3FL9A 1OHKA 2W9HA 4KD7A 1IA3A 3FRFX 3LG4A 4EIZA 3FQFA 4XT4A 4M6KA 1AI9A 4PTJA 4KJJA 2ITHA 1LY4A 1KMSA 3DL6A 4H97A 1RB3A 1RX7A 4ELGA 1RA3A 2JYBA 5ECXA 1LUDA 2C2SA 3QLZA 1KLKA 1RA1A 4XT8A 1RF7A 3EX8A 4M7UA 4KAKA 3F8ZA 3QLYA 2LF1A 3DATA 4TU5X 1M79A 3KJSA 5U26A 3GHCA 4KL9A 2BLAA 1M7AA 3QLSA 1AOEA 4H95A 1DR7A 4FHBA 2W3MA 1IA1A 4H96A 4Q0EA 4ELHA 3JWCA 4Q0DA 3KY8A 1S3VA 2W9SA 4KJKA 1RE7A 1HFRA 3F0BX 1DR4A 3R33A 4QJZD 1KMVA 3TQAA 4M6LA 6DFRA 1DRFA 2ZZAA 1RX6A 2BLBA 3SRRX 1DHJA 1U70A 7DFRA 4FGGA 4PSTA 5HQZA 2W9GA 1DIUA 1S3UA 1LY3A 1PDBA 4XRBA 1DISA 2FZIA 3S7AA 3FRAX 5HSRA 3NZ9X 1DDSA 1RX2A 2FZJA 3SRUX 1RC4A 1YHOA 1DREA 3FRDX 5DFRA 3GHWA 3SA1A 3CL9A 2W9TA 3IA4A 5HVBA 4QLFA 4KFJA 2HQPA 1SEJA 3FQCA 1DYRA 1RA9A 3K2HA 3UM6A 3QL3A 3UM5A 3RO9A 3VCOA 1BZFA 3IRMA 3NTZA 3CSEA 4Q67A 3GYFA 5HI6A 1RH3A 4DDRA 3SR5X 2W3WA 5HPBA 3I8AX 2CD2A 3QYOA 3F0VX 2XW7A 1DHIA 2CIGA 5HT4A 3ZPGA 4ELBA 2KGKA 3NXXA
chains in the Genus database with same CATH superfamily
3FRBX 3NXRA 4Q6AA 3M09A 2BLCA 3E0BA 1J3IA 3EEKA 4G95A 4QJCA 3HBBA 1RB2A 1DDRA 3NXTA 4M6JA 5DXVA 4DP3A 4ECKA 4PSSA 3F0SX 4FGHA 4KJLA 4H98A 4M2XA 1DRAA 2W3VA 4X5GA 2D5NA 3SQYX 1CD2A 1DR2A 1DR5A 2ANQA 1DLRA 1BOZA 1DRBA 3KJRA 5JG0X 3FY8X 4HOEA 3NZDA 4KNEA 2HM9A 1TDRA 3DGAA 2G6VA 4KY4A 3ZPCA 3SRQX 3JVXA 5EAJA 1HFPA 3QLXA 3IX9A 3IA5A 4IXGX 1E26A 4CD2A 1VDRA 3GHVA 1M78A 3K45A 2W3AA 1DG8A 5HQYA 3EIGA 3IROA 3JSUA 3K47A 3SH2A 3HJ3A 1RA8A 3DL5A 4EJ1A 3L3RA 1DLSA 2AZNA 3FQVA 5HVEA 1S3YA 3FREX 2QK8A 4DPDA 2DRCA 4NX7A 1RX8A 2FZHA 3NU0A 5HT5A 4LAGX 1JOMA 3K74A 1DAJA 1PD8A 5FDAA 4P3RA 4EIGA 4GH8A 3INVA 3F8YA 3GI2A 4QLEA 4PTHA 3EEJA 1DYHA 3F0UX 3QG2A 1RX4A 1RX3A 2B3ZA 3NZBX 3TQBA 4QHVA 4EILA 1IA4A 2ANOA 3FYVX 4HA7A 5HSUA 4IXFX 5CC9A 1ZDRA 1J3KA 1DYIA 3OCHA 4X5JA 4PSYA 3JW5A 3NXYA 3F0QX 1DHFA 1RX5A 1DR1A 4KM2A 3NRRA 4M7VA 2C2TA 3TD8A 2H2QA 3SAIA 5CCCA 1OHJA 4OSGA 3SRSX 4P68A 3UM8A 1QZFA 3QFXA 4DFRA 3CD2A 1AO8A 4RGCA 2P4GA 3NXVA 4KBNA 3FS6A 1RX1A 4X5HA 1VJ3A 4G3MA 3TQ9A 1RG7A 3F0XX 4P3QA 1DG5A 3CLBA 4XT5A 3JWFA 2GD9A 3KGYA 1U71A 2D0KA 3DRCA 3D80A 3Q1HA 4ELFA 3NZ6X 5HF0X 2OBCA 4I1NA 3OAFA 4XT7A 3D84X 3DFRA 4PDJA 3N0HA 3TQ8A 2O7PA 3RG9A 4DPHA 4X5FA 3SGYA 4NX6A 3DG8A 3FQOA 1J3JA 4IXED 1RA2A 3NXOA 4HOGA 4KLXA 8DFRA 3QLWA 4ELEA 3JWMA 3EEMA 3EELA 1RX9A 2BL9A 5E8QA 3S9UA 3FQ0A 3FQZA 4KYAA 1DF7A 1CZ3A 4HA9A 1JOLA 4LAHX 4I13A 1HFQA 5HUIA 4QI9A 3FY9X 1DR6A 4KM0A 1DYJA 4XT6A 1D1GA 4XECX 4P66A 3SRWX 4QLGA 4OR7A 4X5IA 5HF2X 3IRNA 1DRHA 3NZCX 3QL0A 4G8ZX 4KEBA 3FYWX 3SA2A 2DHFA 2L28A 4KY8A 3I3RA 1JUVA 3FL8A 4LEKX 2INQA 1S3WA 5U27A 2OIPA 1RD7A 1DR3A 1U72A 3F91A 3S3VA 1MVSA 1DG7A 4LAEX 3KFYA 2W3BA 4XE6X 3DAUA 3M08A 3QLRA 1IA2A 3ROAA 1PD9A 3JWKA 3QGTA 2HXVA 5ECCA 1MVTA 4HOFA 3QYLA 3JTWA 3NZAX 3JW3A 5JA3A 3FL9A 1OHKA 2W9HA 4KD7A 1IA3A 3FRFX 3LG4A 4EIZA 3FQFA 4XT4A 4M6KA 1AI9A 4PTJA 4KJJA 2ITHA 1LY4A 1KMSA 3DL6A 4H97A 1RB3A 1RX7A 4ELGA 1RA3A 2JYBA 5ECXA 1LUDA 2C2SA 3QLZA 1KLKA 1RA1A 4XT8A 1RF7A 3EX8A 4M7UA 4KAKA 3F8ZA 3QLYA 2LF1A 3DATA 4TU5X 1M79A 3KJSA 5U26A 3GHCA 4KL9A 2BLAA 1M7AA 3QLSA 1AOEA 4H95A 1DR7A 4FHBA 2W3MA 1IA1A 4H96A 4Q0EA 4ELHA 3JWCA 4Q0DA 3KY8A 1S3VA 2W9SA 4KJKA 1RE7A 1HFRA 3F0BX 1DR4A 3R33A 4QJZD 1KMVA 3TQAA 4M6LA 6DFRA 1DRFA 2ZZAA 1RX6A 2BLBA 3SRRX 1DHJA 1U70A 7DFRA 4FGGA 4PSTA 5HQZA 2W9GA 1DIUA 1S3UA 1LY3A 1PDBA 4XRBA 1DISA 2FZIA 3S7AA 3FRAX 5HSRA 3NZ9X 1DDSA 1RX2A 2FZJA 3SRUX 1RC4A 1YHOA 1DREA 3FRDX 5DFRA 3GHWA 3SA1A 3CL9A 2W9TA 3IA4A 5HVBA 4QLFA 4KFJA 2HQPA 1SEJA 3FQCA 1DYRA 1RA9A 3K2HA 3UM6A 3QL3A 3UM5A 3RO9A 3VCOA 1BZFA 3IRMA 3NTZA 3CSEA 4Q67A 3GYFA 5HI6A 1RH3A 4DDRA 3SR5X 2W3WA 5HPBA 3I8AX 2CD2A 3QYOA 3F0VX 2XW7A 1DHIA 2CIGA 5HT4A 3ZPGA 4ELBA 2KGKA 3NXXA
chains in the Genus database with same CATH topology
3FRBX 3NXRA 4Q6AA 3M09A 2BLCA 3E0BA 1J3IA 3EEKA 4G95A 4QJCA 3HBBA 1RB2A 1DDRA 3NXTA 4M6JA 5DXVA 4DP3A 4ECKA 4PSSA 3F0SX 4FGHA 4KJLA 4H98A 4M2XA 1DRAA 2W3VA 4X5GA 2D5NA 3SQYX 1CD2A 1DR2A 1DR5A 2ANQA 1DLRA 1BOZA 1DRBA 3KJRA 5JG0X 3FY8X 4HOEA 3NZDA 4KNEA 2HM9A 1TDRA 3DGAA 2G6VA 4KY4A 3ZPCA 3SRQX 3JVXA 5EAJA 1HFPA 3QLXA 3IX9A 3IA5A 4IXGX 1E26A 4CD2A 1VDRA 3GHVA 1M78A 3K45A 2W3AA 1DG8A 5HQYA 3EIGA 3IROA 3JSUA 3K47A 3SH2A 3HJ3A 1RA8A 3DL5A 4EJ1A 3L3RA 1DLSA 2AZNA 3FQVA 5HVEA 1S3YA 3FREX 2QK8A 4DPDA 2DRCA 4NX7A 1RX8A 2FZHA 3NU0A 5HT5A 4LAGX 1JOMA 3K74A 1DAJA 1PD8A 5FDAA 4P3RA 4EIGA 4GH8A 3INVA 3F8YA 3GI2A 4QLEA 4PTHA 3EEJA 1DYHA 3F0UX 3QG2A 1RX4A 1RX3A 2B3ZA 3NZBX 3TQBA 4QHVA 4EILA 1IA4A 2ANOA 3FYVX 4HA7A 5HSUA 4IXFX 5CC9A 1ZDRA 1J3KA 1DYIA 3OCHA 4X5JA 4PSYA 3JW5A 3NXYA 3F0QX 1DHFA 1RX5A 1DR1A 4KM2A 3NRRA 4M7VA 2C2TA 3TD8A 2H2QA 3SAIA 5CCCA 1OHJA 4OSGA 3SRSX 4P68A 3UM8A 1QZFA 3QFXA 4DFRA 3CD2A 1AO8A 4RGCA 2P4GA 3NXVA 4KBNA 3FS6A 1RX1A 4X5HA 1VJ3A 4G3MA 3TQ9A 1RG7A 3F0XX 4P3QA 1DG5A 3CLBA 4XT5A 3JWFA 2GD9A 3KGYA 1U71A 2D0KA 3DRCA 3D80A 3Q1HA 4ELFA 3NZ6X 5HF0X 2OBCA 4I1NA 3OAFA 4XT7A 3D84X 3DFRA 4PDJA 3N0HA 3TQ8A 2O7PA 3RG9A 4DPHA 4X5FA 3SGYA 4NX6A 3DG8A 3FQOA 1J3JA 4IXED 1RA2A 3NXOA 4HOGA 4KLXA 8DFRA 3QLWA 4ELEA 3JWMA 3EEMA 3EELA 1RX9A 2BL9A 5E8QA 3S9UA 3FQ0A 3FQZA 4KYAA 1DF7A 1CZ3A 4HA9A 1JOLA 4LAHX 4I13A 1HFQA 5HUIA 4QI9A 3FY9X 1DR6A 4KM0A 1DYJA 4XT6A 1D1GA 4XECX 4P66A 3SRWX 4QLGA 4OR7A 4X5IA 5HF2X 3IRNA 1DRHA 3NZCX 3QL0A 4G8ZX 4KEBA 3FYWX 3SA2A 2DHFA 2L28A 4KY8A 3I3RA 1JUVA 3FL8A 4LEKX 2INQA 1S3WA 5U27A 2OIPA 1RD7A 1DR3A 1U72A 3F91A 3S3VA 1MVSA 1DG7A 4LAEX 3KFYA 2W3BA 4XE6X 3DAUA 3M08A 3QLRA 1IA2A 3ROAA 1PD9A 3JWKA 3QGTA 2HXVA 5ECCA 1MVTA 4HOFA 3QYLA 3JTWA 3NZAX 3JW3A 5JA3A 3FL9A 1OHKA 2W9HA 4KD7A 1IA3A 3FRFX 3LG4A 4EIZA 3FQFA 4XT4A 4M6KA 1AI9A 4PTJA 4KJJA 2ITHA 1LY4A 1KMSA 3DL6A 4H97A 1RB3A 1RX7A 4ELGA 1RA3A 2JYBA 5ECXA 1LUDA 2C2SA 3QLZA 1KLKA 1RA1A 4XT8A 1RF7A 3EX8A 4M7UA 4KAKA 3F8ZA 3QLYA 2LF1A 3DATA 4TU5X 1M79A 3KJSA 5U26A 3GHCA 4KL9A 2BLAA 1M7AA 3QLSA 1AOEA 4H95A 1DR7A 4FHBA 2W3MA 1IA1A 4H96A 4Q0EA 4ELHA 3JWCA 4Q0DA 3KY8A 1S3VA 2W9SA 4KJKA 1RE7A 1HFRA 3F0BX 1DR4A 3R33A 4QJZD 1KMVA 3TQAA 4M6LA 6DFRA 1DRFA 2ZZAA 1RX6A 2BLBA 3SRRX 1DHJA 1U70A 7DFRA 4FGGA 4PSTA 5HQZA 2W9GA 1DIUA 1S3UA 1LY3A 1PDBA 4XRBA 1DISA 2FZIA 3S7AA 3FRAX 5HSRA 3NZ9X 1DDSA 1RX2A 2FZJA 3SRUX 1RC4A 1YHOA 1DREA 3FRDX 5DFRA 3GHWA 3SA1A 3CL9A 2W9TA 3IA4A 5HVBA 4QLFA 4KFJA 2HQPA 1SEJA 3FQCA 1DYRA 1RA9A 3K2HA 3UM6A 3QL3A 3UM5A 3RO9A 3VCOA 1BZFA 3IRMA 3NTZA 3CSEA 4Q67A 3GYFA 5HI6A 1RH3A 4DDRA 3SR5X 2W3WA 5HPBA 3I8AX 2CD2A 3QYOA 3F0VX 2XW7A 1DHIA 2CIGA 5HT4A 3ZPGA 4ELBA 2KGKA 3NXXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FRB X;  3NXR A;  4Q6A A;  3M09 A;  2BLC A;  3E0B A;  1J3I A;  3EEK A;  4G95 A;  4QJC A;  3HBB A;  1RB2 A;  1DDR A;  3NXT A;  4M6J A;  5DXV A;  4DP3 A;  4ECK A;  4PSS A;  3F0S X;  4FGH A;  4KJL A;  4H98 A;  4M2X A;  1DRA A;  2W3V A;  4X5G A;  2D5N A;  3SQY X;  1CD2 A;  1DR2 A;  1DR5 A;  2ANQ A;  1DLR A;  1BOZ A;  1DRB A;  3KJR A;  5JG0 X;  3FY8 X;  4HOE A;  3NZD A;  4KNE A;  2HM9 A;  1TDR A;  3DGA A;  2G6V A;  4KY4 A;  3ZPC A;  3SRQ X;  3JVX A;  5EAJ A;  1HFP A;  3QLX A;  3IX9 A;  3IA5 A;  4IXG X;  1E26 A;  4CD2 A;  1VDR A;  3GHV A;  1M78 A;  3K45 A;  2W3A A;  1DG8 A;  5HQY A;  3EIG A;  3IRO A;  3JSU A;  3K47 A;  3SH2 A;  3HJ3 A;  1RA8 A;  3DL5 A;  4EJ1 A;  3L3R A;  1DLS A;  2AZN A;  3FQV A;  5HVE A;  1S3Y A;  3FRE X;  2QK8 A;  4DPD A;  2DRC A;  4NX7 A;  1RX8 A;  2FZH A;  3NU0 A;  5HT5 A;  4LAG X;  1JOM A;  3K74 A;  1DAJ A;  1PD8 A;  5FDA A;  4P3R A;  4EIG A;  4GH8 A;  3INV A;  3F8Y A;  3GI2 A;  4QLE A;  4PTH A;  3EEJ A;  1DYH A;  3F0U X;  3QG2 A;  1RX4 A;  1RX3 A;  2B3Z A;  3NZB X;  3TQB A;  4QHV A;  4EIL A;  1IA4 A;  2ANO A;  3FYV X;  4HA7 A;  5HSU A;  4IXF X;  5CC9 A;  1ZDR A;  1J3K A;  1DYI A;  3OCH A;  4X5J A;  4PSY A;  3JW5 A;  3NXY A;  3F0Q X;  1DHF A;  1RX5 A;  1DR1 A;  4KM2 A;  3NRR A;  4M7V A;  2C2T A;  3TD8 A;  2H2Q A;  3SAI A;  5CCC A;  1OHJ A;  4OSG A;  3SRS X;  4P68 A;  3UM8 A;  1QZF A;  3QFX A;  4DFR A;  3CD2 A;  1AO8 A;  4RGC A;  2P4G A;  3NXV A;  4KBN A;  3FS6 A;  1RX1 A;  4X5H A;  1VJ3 A;  4G3M A;  3TQ9 A;  1RG7 A;  3F0X X;  4P3Q A;  1DG5 A;  3CLB A;  4XT5 A;  3JWF A;  2GD9 A;  3KGY A;  1U71 A;  2D0K A;  3DRC A;  3D80 A;  3Q1H A;  4ELF A;  3NZ6 X;  5HF0 X;  2OBC A;  4I1N A;  3OAF A;  4XT7 A;  3D84 X;  3DFR A;  4PDJ A;  3N0H A;  3TQ8 A;  2O7P A;  3RG9 A;  4DPH A;  4X5F A;  3SGY A;  4NX6 A;  3DG8 A;  3FQO A;  1J3J A;  4IXE D;  1RA2 A;  3NXO A;  4HOG A;  4KLX A;  8DFR A;  3QLW A;  4ELE A;  3JWM A;  3EEM A;  3EEL A;  1RX9 A;  2BL9 A;  5E8Q A;  3S9U A;  3FQ0 A;  3FQZ A;  4KYA A;  1DF7 A;  1CZ3 A;  4HA9 A;  1JOL A;  4LAH X;  4I13 A;  1HFQ A;  5HUI A;  4QI9 A;  3FY9 X;  1DR6 A;  4KM0 A;  1DYJ A;  4XT6 A;  1D1G A;  4XEC X;  4P66 A;  3SRW X;  4QLG A;  4OR7 A;  4X5I A;  5HF2 X;  3IRN A;  1DRH A;  3NZC X;  3QL0 A;  4G8Z X;  4KEB A;  3FYW X;  3SA2 A;  2DHF A;  2L28 A;  4KY8 A;  3I3R A;  1JUV A;  3FL8 A;  4LEK X;  2INQ A;  1S3W A;  5U27 A;  2OIP A;  1RD7 A;  1DR3 A;  1U72 A;  3F91 A;  3S3V A;  1MVS A;  1DG7 A;  4LAE X;  3KFY A;  2W3B A;  4XE6 X;  3DAU A;  3M08 A;  3QLR A;  1IA2 A;  3ROA A;  1PD9 A;  3JWK A;  3QGT A;  2HXV A;  5ECC A;  1MVT A;  4HOF A;  3QYL A;  3JTW A;  3NZA X;  3JW3 A;  5JA3 A;  3FL9 A;  1OHK A;  2W9H A;  4KD7 A;  1IA3 A;  3FRF X;  3LG4 A;  4EIZ A;  3FQF A;  4XT4 A;  4M6K A;  1AI9 A;  4PTJ A;  4KJJ A;  2ITH A;  1LY4 A;  1KMS A;  3DL6 A;  4H97 A;  1RB3 A;  1RX7 A;  4ELG A;  1RA3 A;  2JYB A;  5ECX A;  1LUD A;  2C2S A;  3QLZ A;  1KLK A;  1RA1 A;  4XT8 A;  1RF7 A;  3EX8 A;  4M7U A;  4KAK A;  3F8Z A;  3QLY A;  2LF1 A;  3DAT A;  4TU5 X;  1M79 A;  3KJS A;  5U26 A;  3GHC A;  4KL9 A;  2BLA A;  1M7A A;  3QLS A;  1AOE A;  4H95 A;  1DR7 A;  4FHB A;  2W3M A;  1IA1 A;  4H96 A;  4Q0E A;  4ELH A;  3JWC A;  4Q0D A;  3KY8 A;  1S3V A;  2W9S A;  4KJK A;  1RE7 A;  1HFR A;  3F0B X;  1DR4 A;  3R33 A;  4QJZ D;  1KMV A;  3TQA A;  4M6L A;  6DFR A;  1DRF A;  2ZZA A;  1RX6 A;  2BLB A;  3SRR X;  1DHJ A;  1U70 A;  7DFR A;  4FGG A;  4PST A;  5HQZ A;  2W9G A;  1DIU A;  1S3U A;  1LY3 A;  1PDB A;  4XRB A;  1DIS A;  2FZI A;  3S7A A;  3FRA X;  5HSR A;  3NZ9 X;  1DDS A;  1RX2 A;  2FZJ A;  3SRU X;  1RC4 A;  1YHO A;  1DRE A;  3FRD X;  5DFR A;  3GHW A;  3SA1 A;  3CL9 A;  2W9T A;  3IA4 A;  5HVB A;  4QLF A;  4KFJ A;  2HQP A;  1SEJ A;  3FQC A;  1DYR A;  1RA9 A;  3K2H A;  3UM6 A;  3QL3 A;  3UM5 A;  3RO9 A;  3VCO A;  1BZF A;  3IRM A;  3NTZ A;  3CSE A;  4Q67 A;  3GYF A;  5HI6 A;  1RH3 A;  4DDR A;  3SR5 X;  2W3W A;  5HPB A;  3I8A X;  2CD2 A;  3QYO A;  3F0V X;  2XW7 A;  1DHI A;  2CIG A;  5HT4 A;  3ZPG A;  4ELB A;  2KGK A;  3NXX A; 
#chains in the Genus database with same CATH topology
 3FRB X;  3NXR A;  4Q6A A;  3M09 A;  2BLC A;  3E0B A;  1J3I A;  3EEK A;  4G95 A;  4QJC A;  3HBB A;  1RB2 A;  1DDR A;  3NXT A;  4M6J A;  5DXV A;  4DP3 A;  4ECK A;  4PSS A;  3F0S X;  4FGH A;  4KJL A;  4H98 A;  4M2X A;  1DRA A;  2W3V A;  4X5G A;  2D5N A;  3SQY X;  1CD2 A;  1DR2 A;  1DR5 A;  2ANQ A;  1DLR A;  1BOZ A;  1DRB A;  3KJR A;  5JG0 X;  3FY8 X;  4HOE A;  3NZD A;  4KNE A;  2HM9 A;  1TDR A;  3DGA A;  2G6V A;  4KY4 A;  3ZPC A;  3SRQ X;  3JVX A;  5EAJ A;  1HFP A;  3QLX A;  3IX9 A;  3IA5 A;  4IXG X;  1E26 A;  4CD2 A;  1VDR A;  3GHV A;  1M78 A;  3K45 A;  2W3A A;  1DG8 A;  5HQY A;  3EIG A;  3IRO A;  3JSU A;  3K47 A;  3SH2 A;  3HJ3 A;  1RA8 A;  3DL5 A;  4EJ1 A;  3L3R A;  1DLS A;  2AZN A;  3FQV A;  5HVE A;  1S3Y A;  3FRE X;  2QK8 A;  4DPD A;  2DRC A;  4NX7 A;  1RX8 A;  2FZH A;  3NU0 A;  5HT5 A;  4LAG X;  1JOM A;  3K74 A;  1DAJ A;  1PD8 A;  5FDA A;  4P3R A;  4EIG A;  4GH8 A;  3INV A;  3F8Y A;  3GI2 A;  4QLE A;  4PTH A;  3EEJ A;  1DYH A;  3F0U X;  3QG2 A;  1RX4 A;  1RX3 A;  2B3Z A;  3NZB X;  3TQB A;  4QHV A;  4EIL A;  1IA4 A;  2ANO A;  3FYV X;  4HA7 A;  5HSU A;  4IXF X;  5CC9 A;  1ZDR A;  1J3K A;  1DYI A;  3OCH A;  4X5J A;  4PSY A;  3JW5 A;  3NXY A;  3F0Q X;  1DHF A;  1RX5 A;  1DR1 A;  4KM2 A;  3NRR A;  4M7V A;  2C2T A;  3TD8 A;  2H2Q A;  3SAI A;  5CCC A;  1OHJ A;  4OSG A;  3SRS X;  4P68 A;  3UM8 A;  1QZF A;  3QFX A;  4DFR A;  3CD2 A;  1AO8 A;  4RGC A;  2P4G A;  3NXV A;  4KBN A;  3FS6 A;  1RX1 A;  4X5H A;  1VJ3 A;  4G3M A;  3TQ9 A;  1RG7 A;  3F0X X;  4P3Q A;  1DG5 A;  3CLB A;  4XT5 A;  3JWF A;  2GD9 A;  3KGY A;  1U71 A;  2D0K A;  3DRC A;  3D80 A;  3Q1H A;  4ELF A;  3NZ6 X;  5HF0 X;  2OBC A;  4I1N A;  3OAF A;  4XT7 A;  3D84 X;  3DFR A;  4PDJ A;  3N0H A;  3TQ8 A;  2O7P A;  3RG9 A;  4DPH A;  4X5F A;  3SGY A;  4NX6 A;  3DG8 A;  3FQO A;  1J3J A;  4IXE D;  1RA2 A;  3NXO A;  4HOG A;  4KLX A;  8DFR A;  3QLW A;  4ELE A;  3JWM A;  3EEM A;  3EEL A;  1RX9 A;  2BL9 A;  5E8Q A;  3S9U A;  3FQ0 A;  3FQZ A;  4KYA A;  1DF7 A;  1CZ3 A;  4HA9 A;  1JOL A;  4LAH X;  4I13 A;  1HFQ A;  5HUI A;  4QI9 A;  3FY9 X;  1DR6 A;  4KM0 A;  1DYJ A;  4XT6 A;  1D1G A;  4XEC X;  4P66 A;  3SRW X;  4QLG A;  4OR7 A;  4X5I A;  5HF2 X;  3IRN A;  1DRH A;  3NZC X;  3QL0 A;  4G8Z X;  4KEB A;  3FYW X;  3SA2 A;  2DHF A;  2L28 A;  4KY8 A;  3I3R A;  1JUV A;  3FL8 A;  4LEK X;  2INQ A;  1S3W A;  5U27 A;  2OIP A;  1RD7 A;  1DR3 A;  1U72 A;  3F91 A;  3S3V A;  1MVS A;  1DG7 A;  4LAE X;  3KFY A;  2W3B A;  4XE6 X;  3DAU A;  3M08 A;  3QLR A;  1IA2 A;  3ROA A;  1PD9 A;  3JWK A;  3QGT A;  2HXV A;  5ECC A;  1MVT A;  4HOF A;  3QYL A;  3JTW A;  3NZA X;  3JW3 A;  5JA3 A;  3FL9 A;  1OHK A;  2W9H A;  4KD7 A;  1IA3 A;  3FRF X;  3LG4 A;  4EIZ A;  3FQF A;  4XT4 A;  4M6K A;  1AI9 A;  4PTJ A;  4KJJ A;  2ITH A;  1LY4 A;  1KMS A;  3DL6 A;  4H97 A;  1RB3 A;  1RX7 A;  4ELG A;  1RA3 A;  2JYB A;  5ECX A;  1LUD A;  2C2S A;  3QLZ A;  1KLK A;  1RA1 A;  4XT8 A;  1RF7 A;  3EX8 A;  4M7U A;  4KAK A;  3F8Z A;  3QLY A;  2LF1 A;  3DAT A;  4TU5 X;  1M79 A;  3KJS A;  5U26 A;  3GHC A;  4KL9 A;  2BLA A;  1M7A A;  3QLS A;  1AOE A;  4H95 A;  1DR7 A;  4FHB A;  2W3M A;  1IA1 A;  4H96 A;  4Q0E A;  4ELH A;  3JWC A;  4Q0D A;  3KY8 A;  1S3V A;  2W9S A;  4KJK A;  1RE7 A;  1HFR A;  3F0B X;  1DR4 A;  3R33 A;  4QJZ D;  1KMV A;  3TQA A;  4M6L A;  6DFR A;  1DRF A;  2ZZA A;  1RX6 A;  2BLB A;  3SRR X;  1DHJ A;  1U70 A;  7DFR A;  4FGG A;  4PST A;  5HQZ A;  2W9G A;  1DIU A;  1S3U A;  1LY3 A;  1PDB A;  4XRB A;  1DIS A;  2FZI A;  3S7A A;  3FRA X;  5HSR A;  3NZ9 X;  1DDS A;  1RX2 A;  2FZJ A;  3SRU X;  1RC4 A;  1YHO A;  1DRE A;  3FRD X;  5DFR A;  3GHW A;  3SA1 A;  3CL9 A;  2W9T A;  3IA4 A;  5HVB A;  4QLF A;  4KFJ A;  2HQP A;  1SEJ A;  3FQC A;  1DYR A;  1RA9 A;  3K2H A;  3UM6 A;  3QL3 A;  3UM5 A;  3RO9 A;  3VCO A;  1BZF A;  3IRM A;  3NTZ A;  3CSE A;  4Q67 A;  3GYF A;  5HI6 A;  1RH3 A;  4DDR A;  3SR5 X;  2W3W A;  5HPB A;  3I8A X;  2CD2 A;  3QYO A;  3F0V X;  2XW7 A;  1DHI A;  2CIG A;  5HT4 A;  3ZPG A;  4ELB A;  2KGK A;  3NXX A; 
#chains in the Genus database with same CATH homology
 3FRB X;  3NXR A;  4Q6A A;  3M09 A;  2BLC A;  3E0B A;  1J3I A;  3EEK A;  4G95 A;  4QJC A;  3HBB A;  1RB2 A;  1DDR A;  3NXT A;  4M6J A;  5DXV A;  4DP3 A;  4ECK A;  4PSS A;  3F0S X;  4FGH A;  4KJL A;  4H98 A;  4M2X A;  1DRA A;  2W3V A;  4X5G A;  2D5N A;  3SQY X;  1CD2 A;  1DR2 A;  1DR5 A;  2ANQ A;  1DLR A;  1BOZ A;  1DRB A;  3KJR A;  5JG0 X;  3FY8 X;  4HOE A;  3NZD A;  4KNE A;  2HM9 A;  1TDR A;  3DGA A;  2G6V A;  4KY4 A;  3ZPC A;  3SRQ X;  3JVX A;  5EAJ A;  1HFP A;  3QLX A;  3IX9 A;  3IA5 A;  4IXG X;  1E26 A;  4CD2 A;  1VDR A;  3GHV A;  1M78 A;  3K45 A;  2W3A A;  1DG8 A;  5HQY A;  3EIG A;  3IRO A;  3JSU A;  3K47 A;  3SH2 A;  3HJ3 A;  1RA8 A;  3DL5 A;  4EJ1 A;  3L3R A;  1DLS A;  2AZN A;  3FQV A;  5HVE A;  1S3Y A;  3FRE X;  2QK8 A;  4DPD A;  2DRC A;  4NX7 A;  1RX8 A;  2FZH A;  3NU0 A;  5HT5 A;  4LAG X;  1JOM A;  3K74 A;  1DAJ A;  1PD8 A;  5FDA A;  4P3R A;  4EIG A;  4GH8 A;  3INV A;  3F8Y A;  3GI2 A;  4QLE A;  4PTH A;  3EEJ A;  1DYH A;  3F0U X;  3QG2 A;  1RX4 A;  1RX3 A;  2B3Z A;  3NZB X;  3TQB A;  4QHV A;  4EIL A;  1IA4 A;  2ANO A;  3FYV X;  4HA7 A;  5HSU A;  4IXF X;  5CC9 A;  1ZDR A;  1J3K A;  1DYI A;  3OCH A;  4X5J A;  4PSY A;  3JW5 A;  3NXY A;  3F0Q X;  1DHF A;  1RX5 A;  1DR1 A;  4KM2 A;  3NRR A;  4M7V A;  2C2T A;  3TD8 A;  2H2Q A;  3SAI A;  5CCC A;  1OHJ A;  4OSG A;  3SRS X;  4P68 A;  3UM8 A;  1QZF A;  3QFX A;  4DFR A;  3CD2 A;  1AO8 A;  4RGC A;  2P4G A;  3NXV A;  4KBN A;  3FS6 A;  1RX1 A;  4X5H A;  1VJ3 A;  4G3M A;  3TQ9 A;  1RG7 A;  3F0X X;  4P3Q A;  1DG5 A;  3CLB A;  4XT5 A;  3JWF A;  2GD9 A;  3KGY A;  1U71 A;  2D0K A;  3DRC A;  3D80 A;  3Q1H A;  4ELF A;  3NZ6 X;  5HF0 X;  2OBC A;  4I1N A;  3OAF A;  4XT7 A;  3D84 X;  3DFR A;  4PDJ A;  3N0H A;  3TQ8 A;  2O7P A;  3RG9 A;  4DPH A;  4X5F A;  3SGY A;  4NX6 A;  3DG8 A;  3FQO A;  1J3J A;  4IXE D;  1RA2 A;  3NXO A;  4HOG A;  4KLX A;  8DFR A;  3QLW A;  4ELE A;  3JWM A;  3EEM A;  3EEL A;  1RX9 A;  2BL9 A;  5E8Q A;  3S9U A;  3FQ0 A;  3FQZ A;  4KYA A;  1DF7 A;  1CZ3 A;  4HA9 A;  1JOL A;  4LAH X;  4I13 A;  1HFQ A;  5HUI A;  4QI9 A;  3FY9 X;  1DR6 A;  4KM0 A;  1DYJ A;  4XT6 A;  1D1G A;  4XEC X;  4P66 A;  3SRW X;  4QLG A;  4OR7 A;  4X5I A;  5HF2 X;  3IRN A;  1DRH A;  3NZC X;  3QL0 A;  4G8Z X;  4KEB A;  3FYW X;  3SA2 A;  2DHF A;  2L28 A;  4KY8 A;  3I3R A;  1JUV A;  3FL8 A;  4LEK X;  2INQ A;  1S3W A;  5U27 A;  2OIP A;  1RD7 A;  1DR3 A;  1U72 A;  3F91 A;  3S3V A;  1MVS A;  1DG7 A;  4LAE X;  3KFY A;  2W3B A;  4XE6 X;  3DAU A;  3M08 A;  3QLR A;  1IA2 A;  3ROA A;  1PD9 A;  3JWK A;  3QGT A;  2HXV A;  5ECC A;  1MVT A;  4HOF A;  3QYL A;  3JTW A;  3NZA X;  3JW3 A;  5JA3 A;  3FL9 A;  1OHK A;  2W9H A;  4KD7 A;  1IA3 A;  3FRF X;  3LG4 A;  4EIZ A;  3FQF A;  4XT4 A;  4M6K A;  1AI9 A;  4PTJ A;  4KJJ A;  2ITH A;  1LY4 A;  1KMS A;  3DL6 A;  4H97 A;  1RB3 A;  1RX7 A;  4ELG A;  1RA3 A;  2JYB A;  5ECX A;  1LUD A;  2C2S A;  3QLZ A;  1KLK A;  1RA1 A;  4XT8 A;  1RF7 A;  3EX8 A;  4M7U A;  4KAK A;  3F8Z A;  3QLY A;  2LF1 A;  3DAT A;  4TU5 X;  1M79 A;  3KJS A;  5U26 A;  3GHC A;  4KL9 A;  2BLA A;  1M7A A;  3QLS A;  1AOE A;  4H95 A;  1DR7 A;  4FHB A;  2W3M A;  1IA1 A;  4H96 A;  4Q0E A;  4ELH A;  3JWC A;  4Q0D A;  3KY8 A;  1S3V A;  2W9S A;  4KJK A;  1RE7 A;  1HFR A;  3F0B X;  1DR4 A;  3R33 A;  4QJZ D;  1KMV A;  3TQA A;  4M6L A;  6DFR A;  1DRF A;  2ZZA A;  1RX6 A;  2BLB A;  3SRR X;  1DHJ A;  1U70 A;  7DFR A;  4FGG A;  4PST A;  5HQZ A;  2W9G A;  1DIU A;  1S3U A;  1LY3 A;  1PDB A;  4XRB A;  1DIS A;  2FZI A;  3S7A A;  3FRA X;  5HSR A;  3NZ9 X;  1DDS A;  1RX2 A;  2FZJ A;  3SRU X;  1RC4 A;  1YHO A;  1DRE A;  3FRD X;  5DFR A;  3GHW A;  3SA1 A;  3CL9 A;  2W9T A;  3IA4 A;  5HVB A;  4QLF A;  4KFJ A;  2HQP A;  1SEJ A;  3FQC A;  1DYR A;  1RA9 A;  3K2H A;  3UM6 A;  3QL3 A;  3UM5 A;  3RO9 A;  3VCO A;  1BZF A;  3IRM A;  3NTZ A;  3CSE A;  4Q67 A;  3GYF A;  5HI6 A;  1RH3 A;  4DDR A;  3SR5 X;  2W3W A;  5HPB A;  3I8A X;  2CD2 A;  3QYO A;  3F0V X;  2XW7 A;  1DHI A;  2CIG A;  5HT4 A;  3ZPG A;  4ELB A;  2KGK A;  3NXX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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