1DRBA

Crystal structure of unliganded escherichia coli dihydrofolate reductase. ligand-induced conformational changes and cooperativity in binding
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPACLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 44
structure length 159
sequence length 159
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1991-11-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1drbA00
4HA7A 3ZPCA 4ELGA 1KLKA 3FYVX 3FQZA 4EJ1A 1DRFA 4NX7A 4PDJA 5HT5A 3I3RA 3EELA 3F0QX 3SA1A 5EAJA 4EIZA 4QLFA 5HSUA 2DHFA 3OAFA 1SEJA 3QL3A 4QHVA 3KFYA 1RX7A 5U26A 2D0KA 2ANOA 4I1NA 3TQAA 3GHVA 1DHFA 4XT7A 1DR4A 2H2QA 5HF0X 1AO8A 3QFXA 4P68A 3F0XX 3DAUA 4TU5X 4KYAA 1JUVA 3F0VX 2W3MA 3UM5A 4LEKX 3JW3A 3SRRX 3IA4A 1M79A 3SR5X 2BL9A 4QLEA 1RX6A 1RX8A 3QLSA 3CSEA 4XECX 7DFRA 3QYLA 1S3WA 1RA1A 3SAIA 1DREA 4ELHA 1RX2A 3S3VA 2OIPA 2FZHA 3TD8A 2W9HA 4M7UA 1RE7A 1YHOA 3QLWA 4PSYA 1RG7A 3VCOA 3CD2A 1MVTA 1RX3A 1BZFA 1DG8A 1IA3A 1DHIA 1RX9A 1DRHA 3CL9A 1RA3A 1DYHA 3K2HA 4XT6A 4DPHA 2JYBA 4LAEX 3UM8A 4Q0EA 3SQYX 3SA2A 4GH8A 3F8ZA 2B3ZA 2KGKA 2W9SA 4KLXA 1ZDRA 4XT5A 1DYIA 3FYWX 1DR2A 1VJ3A 3EEJA 3N0HA 4KFJA 1DDSA 4KL9A 2HQPA 3GHWA 2GD9A 4M6KA 1S3YA 4G3MA 3E0BA 3KY8A 1AI9A 3R33A 3FS6A 3KJRA 4LAGX 1RB3A 3Q1HA 1DIUA 2OBCA 4ELFA 3ROAA 1JOLA 1PD9A 4KJKA 1OHJA 4IXFX 3JW5A 3QLZA 2CD2A 2INQA 4QLGA 3FREX 5ECCA 4IXGX 3OCHA 2CIGA 4X5GA 1KMSA 4Q6AA 3DL6A 4KM0A 5CC9A 5HUIA 3NXRA 4FHBA 1RX5A 5FDAA 3NZCX 3NXVA 3F8YA 1J3JA 3RG9A 3SRQX 3FQOA 2XW7A 5HT4A 3JSUA 1DR3A 5HVBA 5HQZA 3F0UX 3SRWX 1DLRA 3TQ8A 1DISA 3M08A 3M09A 1RH3A 1PD8A 4QI9A 3QGTA 4ELEA 1E26A 1LY4A 1DG7A 4QJCA 3NXXA 2FZIA 1RC4A 3F91A 3NZDA 4CD2A 2W3WA 3DATA 2G6VA 1VDRA 4Q67A 5DFRA 4DP3A 4DDRA 4LAHX 1DLSA 2W3BA 3F0SX 3FL9A 3EIGA 6DFRA 1RA8A 3FY8X 4M7VA 4KM2A 1CD2A 3K45A 3JWFA 4QJZD 4XT4A 3SH2A 2BLCA 1IA2A 3EEMA 1OHKA 3K74A 3K47A 3NZ6X 3CLBA 1LY3A 3DFRA 1S3UA 1DR6A 3NRRA 3QLRA 1DYRA 3I8AX 4H96A 4M6JA 3TQ9A 1LUDA 4RGCA 4FGGA 3IRNA 2HXVA 4KBNA 4KAKA 4X5IA 3DG8A 5HVEA 3LG4A 3IRMA 1DRAA 3L3RA 3GI2A 3RO9A 2P4GA 4H97A 4P3QA 4KY8A 2AZNA 1DR7A 3SGYA 3QLYA 4PTHA 1PDBA 3NZAX 1DF7A 2W3VA 2DRCA 2D5NA 3S7AA 3GHCA 3SRUX 1S3VA 1DG5A 2BLAA 5U27A 2FZJA 3HJ3A 1IA4A 3EX8A 3DL5A 2ANQA 5DXVA 5HSRA 3QL0A 1DAJA 2HM9A 3JWKA 3FQFA 4XT8A 1U71A 4HA9A 3JWMA 3FRDX 3SRSX 2ITHA 4X5HA 3NXYA 1RX4A 3KJSA 4X5JA 3INVA 2W9TA 4ECKA 3NZ9X 1JOMA 1J3IA 3TQBA 2C2SA 3GYFA 4EIGA 5JA3A 3DRCA 1U70A 4HOEA 1DHJA 4ELBA 4H98A 4IXED 4X5FA 3NXOA 3F0BX 4DPDA 3NU0A 1M7AA 1DR5A 3EEKA 4G95A 1DDRA 3HBBA 3FRBX 4EILA 4P66A 1M78A 4M2XA 1RA2A 2QK8A 3JVXA 1U72A 4KEBA 4HOFA 2BLBA 4HOGA 4H95A 5HPBA 4KJJA 4PSSA 4FGHA 1HFPA 4M6LA 1DRBA 4NX6A 2L28A 3FQ0A 3FQCA 3IA5A 3NTZA 2O7PA 1RD7A 1RX1A 3DGAA 5CCCA 4P3RA 4KY4A 3KGYA 1MVSA 1IA1A 1BOZA 3FQVA 5HF2X 3D80A 1AOEA 3NXTA 1J3KA 4XE6X 5HQYA 1QZFA 1HFQA 1DR1A 1DYJA 4KNEA 3IX9A 3S9UA 3QG2A 3ZPGA 3JWCA 2ZZAA 3QYOA 1CZ3A 4KJLA 3UM6A 3FRFX 4OSGA 1RF7A 4PTJA 3D84X 1KMVA 4DFRA 1HFRA 8DFRA 1RB2A 5HI6A 3QLXA 5E8QA 2W3AA 1RA9A 2W9GA 3NZBX 1TDRA 3JTWA 3FL8A 3IROA 4G8ZX 3FRAX 4OR7A 4KD7A 5JG0X 2LF1A 5ECXA 4XRBA 1D1GA 4I13A 4Q0DA 2C2TA 3FY9X 4PSTA
chains in the Genus database with same CATH superfamily
4HA7A 3ZPCA 4ELGA 1KLKA 3FYVX 3FQZA 4EJ1A 1DRFA 4NX7A 4PDJA 5HT5A 3I3RA 3EELA 3F0QX 3SA1A 5EAJA 4EIZA 4QLFA 5HSUA 2DHFA 3OAFA 1SEJA 3QL3A 4QHVA 3KFYA 1RX7A 5U26A 2D0KA 2ANOA 4I1NA 3TQAA 3GHVA 1DHFA 4XT7A 1DR4A 2H2QA 5HF0X 1AO8A 3QFXA 4P68A 3F0XX 3DAUA 4TU5X 4KYAA 1JUVA 3F0VX 2W3MA 3UM5A 4LEKX 3JW3A 3SRRX 3IA4A 1M79A 3SR5X 2BL9A 4QLEA 1RX6A 1RX8A 3QLSA 3CSEA 4XECX 7DFRA 3QYLA 1S3WA 1RA1A 3SAIA 1DREA 4ELHA 1RX2A 3S3VA 2OIPA 2FZHA 3TD8A 2W9HA 4M7UA 1RE7A 1YHOA 3QLWA 4PSYA 1RG7A 3VCOA 3CD2A 1MVTA 1RX3A 1BZFA 1DG8A 1IA3A 1DHIA 1RX9A 1DRHA 3CL9A 1RA3A 1DYHA 3K2HA 4XT6A 4DPHA 2JYBA 4LAEX 3UM8A 4Q0EA 3SQYX 3SA2A 4GH8A 3F8ZA 2B3ZA 2KGKA 2W9SA 4KLXA 1ZDRA 4XT5A 1DYIA 3FYWX 1DR2A 1VJ3A 3EEJA 3N0HA 4KFJA 1DDSA 4KL9A 2HQPA 3GHWA 2GD9A 4M6KA 1S3YA 4G3MA 3E0BA 3KY8A 1AI9A 3R33A 3FS6A 3KJRA 4LAGX 1RB3A 3Q1HA 1DIUA 2OBCA 4ELFA 3ROAA 1JOLA 1PD9A 4KJKA 1OHJA 4IXFX 3JW5A 3QLZA 2CD2A 2INQA 4QLGA 3FREX 5ECCA 4IXGX 3OCHA 2CIGA 4X5GA 1KMSA 4Q6AA 3DL6A 4KM0A 5CC9A 5HUIA 3NXRA 4FHBA 1RX5A 5FDAA 3NZCX 3NXVA 3F8YA 1J3JA 3RG9A 3SRQX 3FQOA 2XW7A 5HT4A 3JSUA 1DR3A 5HVBA 5HQZA 3F0UX 3SRWX 1DLRA 3TQ8A 1DISA 3M08A 3M09A 1RH3A 1PD8A 4QI9A 3QGTA 4ELEA 1E26A 1LY4A 1DG7A 4QJCA 3NXXA 2FZIA 1RC4A 3F91A 3NZDA 4CD2A 2W3WA 3DATA 2G6VA 1VDRA 4Q67A 5DFRA 4DP3A 4DDRA 4LAHX 1DLSA 2W3BA 3F0SX 3FL9A 3EIGA 6DFRA 1RA8A 3FY8X 4M7VA 4KM2A 1CD2A 3K45A 3JWFA 4QJZD 4XT4A 3SH2A 2BLCA 1IA2A 3EEMA 1OHKA 3K74A 3K47A 3NZ6X 3CLBA 1LY3A 3DFRA 1S3UA 1DR6A 3NRRA 3QLRA 1DYRA 3I8AX 4H96A 4M6JA 3TQ9A 1LUDA 4RGCA 4FGGA 3IRNA 2HXVA 4KBNA 4KAKA 4X5IA 3DG8A 5HVEA 3LG4A 3IRMA 1DRAA 3L3RA 3GI2A 3RO9A 2P4GA 4H97A 4P3QA 4KY8A 2AZNA 1DR7A 3SGYA 3QLYA 4PTHA 1PDBA 3NZAX 1DF7A 2W3VA 2DRCA 2D5NA 3S7AA 3GHCA 3SRUX 1S3VA 1DG5A 2BLAA 5U27A 2FZJA 3HJ3A 1IA4A 3EX8A 3DL5A 2ANQA 5DXVA 5HSRA 3QL0A 1DAJA 2HM9A 3JWKA 3FQFA 4XT8A 1U71A 4HA9A 3JWMA 3FRDX 3SRSX 2ITHA 4X5HA 3NXYA 1RX4A 3KJSA 4X5JA 3INVA 2W9TA 4ECKA 3NZ9X 1JOMA 1J3IA 3TQBA 2C2SA 3GYFA 4EIGA 5JA3A 3DRCA 1U70A 4HOEA 1DHJA 4ELBA 4H98A 4IXED 4X5FA 3NXOA 3F0BX 4DPDA 3NU0A 1M7AA 1DR5A 3EEKA 4G95A 1DDRA 3HBBA 3FRBX 4EILA 4P66A 1M78A 4M2XA 1RA2A 2QK8A 3JVXA 1U72A 4KEBA 4HOFA 2BLBA 4HOGA 4H95A 5HPBA 4KJJA 4PSSA 4FGHA 1HFPA 4M6LA 1DRBA 4NX6A 2L28A 3FQ0A 3FQCA 3IA5A 3NTZA 2O7PA 1RD7A 1RX1A 3DGAA 5CCCA 4P3RA 4KY4A 3KGYA 1MVSA 1IA1A 1BOZA 3FQVA 5HF2X 3D80A 1AOEA 3NXTA 1J3KA 4XE6X 5HQYA 1QZFA 1HFQA 1DR1A 1DYJA 4KNEA 3IX9A 3S9UA 3QG2A 3ZPGA 3JWCA 2ZZAA 3QYOA 1CZ3A 4KJLA 3UM6A 3FRFX 4OSGA 1RF7A 4PTJA 3D84X 1KMVA 4DFRA 1HFRA 8DFRA 1RB2A 5HI6A 3QLXA 5E8QA 2W3AA 1RA9A 2W9GA 3NZBX 1TDRA 3JTWA 3FL8A 3IROA 4G8ZX 3FRAX 4OR7A 4KD7A 5JG0X 2LF1A 5ECXA 4XRBA 1D1GA 4I13A 4Q0DA 2C2TA 3FY9X 4PSTA
chains in the Genus database with same CATH topology
4HA7A 3ZPCA 4ELGA 1KLKA 3FYVX 3FQZA 4EJ1A 1DRFA 4NX7A 4PDJA 5HT5A 3I3RA 3EELA 3F0QX 3SA1A 5EAJA 4EIZA 4QLFA 5HSUA 2DHFA 3OAFA 1SEJA 3QL3A 4QHVA 3KFYA 1RX7A 5U26A 2D0KA 2ANOA 4I1NA 3TQAA 3GHVA 1DHFA 4XT7A 1DR4A 2H2QA 5HF0X 1AO8A 3QFXA 4P68A 3F0XX 3DAUA 4TU5X 4KYAA 1JUVA 3F0VX 2W3MA 3UM5A 4LEKX 3JW3A 3SRRX 3IA4A 1M79A 3SR5X 2BL9A 4QLEA 1RX6A 1RX8A 3QLSA 3CSEA 4XECX 7DFRA 3QYLA 1S3WA 1RA1A 3SAIA 1DREA 4ELHA 1RX2A 3S3VA 2OIPA 2FZHA 3TD8A 2W9HA 4M7UA 1RE7A 1YHOA 3QLWA 4PSYA 1RG7A 3VCOA 3CD2A 1MVTA 1RX3A 1BZFA 1DG8A 1IA3A 1DHIA 1RX9A 1DRHA 3CL9A 1RA3A 1DYHA 3K2HA 4XT6A 4DPHA 2JYBA 4LAEX 3UM8A 4Q0EA 3SQYX 3SA2A 4GH8A 3F8ZA 2B3ZA 2KGKA 2W9SA 4KLXA 1ZDRA 4XT5A 1DYIA 3FYWX 1DR2A 1VJ3A 3EEJA 3N0HA 4KFJA 1DDSA 4KL9A 2HQPA 3GHWA 2GD9A 4M6KA 1S3YA 4G3MA 3E0BA 3KY8A 1AI9A 3R33A 3FS6A 3KJRA 4LAGX 1RB3A 3Q1HA 1DIUA 2OBCA 4ELFA 3ROAA 1JOLA 1PD9A 4KJKA 1OHJA 4IXFX 3JW5A 3QLZA 2CD2A 2INQA 4QLGA 3FREX 5ECCA 4IXGX 3OCHA 2CIGA 4X5GA 1KMSA 4Q6AA 3DL6A 4KM0A 5CC9A 5HUIA 3NXRA 4FHBA 1RX5A 5FDAA 3NZCX 3NXVA 3F8YA 1J3JA 3RG9A 3SRQX 3FQOA 2XW7A 5HT4A 3JSUA 1DR3A 5HVBA 5HQZA 3F0UX 3SRWX 1DLRA 3TQ8A 1DISA 3M08A 3M09A 1RH3A 1PD8A 4QI9A 3QGTA 4ELEA 1E26A 1LY4A 1DG7A 4QJCA 3NXXA 2FZIA 1RC4A 3F91A 3NZDA 4CD2A 2W3WA 3DATA 2G6VA 1VDRA 4Q67A 5DFRA 4DP3A 4DDRA 4LAHX 1DLSA 2W3BA 3F0SX 3FL9A 3EIGA 6DFRA 1RA8A 3FY8X 4M7VA 4KM2A 1CD2A 3K45A 3JWFA 4QJZD 4XT4A 3SH2A 2BLCA 1IA2A 3EEMA 1OHKA 3K74A 3K47A 3NZ6X 3CLBA 1LY3A 3DFRA 1S3UA 1DR6A 3NRRA 3QLRA 1DYRA 3I8AX 4H96A 4M6JA 3TQ9A 1LUDA 4RGCA 4FGGA 3IRNA 2HXVA 4KBNA 4KAKA 4X5IA 3DG8A 5HVEA 3LG4A 3IRMA 1DRAA 3L3RA 3GI2A 3RO9A 2P4GA 4H97A 4P3QA 4KY8A 2AZNA 1DR7A 3SGYA 3QLYA 4PTHA 1PDBA 3NZAX 1DF7A 2W3VA 2DRCA 2D5NA 3S7AA 3GHCA 3SRUX 1S3VA 1DG5A 2BLAA 5U27A 2FZJA 3HJ3A 1IA4A 3EX8A 3DL5A 2ANQA 5DXVA 5HSRA 3QL0A 1DAJA 2HM9A 3JWKA 3FQFA 4XT8A 1U71A 4HA9A 3JWMA 3FRDX 3SRSX 2ITHA 4X5HA 3NXYA 1RX4A 3KJSA 4X5JA 3INVA 2W9TA 4ECKA 3NZ9X 1JOMA 1J3IA 3TQBA 2C2SA 3GYFA 4EIGA 5JA3A 3DRCA 1U70A 4HOEA 1DHJA 4ELBA 4H98A 4IXED 4X5FA 3NXOA 3F0BX 4DPDA 3NU0A 1M7AA 1DR5A 3EEKA 4G95A 1DDRA 3HBBA 3FRBX 4EILA 4P66A 1M78A 4M2XA 1RA2A 2QK8A 3JVXA 1U72A 4KEBA 4HOFA 2BLBA 4HOGA 4H95A 5HPBA 4KJJA 4PSSA 4FGHA 1HFPA 4M6LA 1DRBA 4NX6A 2L28A 3FQ0A 3FQCA 3IA5A 3NTZA 2O7PA 1RD7A 1RX1A 3DGAA 5CCCA 4P3RA 4KY4A 3KGYA 1MVSA 1IA1A 1BOZA 3FQVA 5HF2X 3D80A 1AOEA 3NXTA 1J3KA 4XE6X 5HQYA 1QZFA 1HFQA 1DR1A 1DYJA 4KNEA 3IX9A 3S9UA 3QG2A 3ZPGA 3JWCA 2ZZAA 3QYOA 1CZ3A 4KJLA 3UM6A 3FRFX 4OSGA 1RF7A 4PTJA 3D84X 1KMVA 4DFRA 1HFRA 8DFRA 1RB2A 5HI6A 3QLXA 5E8QA 2W3AA 1RA9A 2W9GA 3NZBX 1TDRA 3JTWA 3FL8A 3IROA 4G8ZX 3FRAX 4OR7A 4KD7A 5JG0X 2LF1A 5ECXA 4XRBA 1D1GA 4I13A 4Q0DA 2C2TA 3FY9X 4PSTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HA7 A;  3ZPC A;  4ELG A;  1KLK A;  3FYV X;  3FQZ A;  4EJ1 A;  1DRF A;  4NX7 A;  4PDJ A;  5HT5 A;  3I3R A;  3EEL A;  3F0Q X;  3SA1 A;  5EAJ A;  4EIZ A;  4QLF A;  5HSU A;  2DHF A;  3OAF A;  1SEJ A;  3QL3 A;  4QHV A;  3KFY A;  1RX7 A;  5U26 A;  2D0K A;  2ANO A;  4I1N A;  3TQA A;  3GHV A;  1DHF A;  4XT7 A;  1DR4 A;  2H2Q A;  5HF0 X;  1AO8 A;  3QFX A;  4P68 A;  3F0X X;  3DAU A;  4TU5 X;  4KYA A;  1JUV A;  3F0V X;  2W3M A;  3UM5 A;  4LEK X;  3JW3 A;  3SRR X;  3IA4 A;  1M79 A;  3SR5 X;  2BL9 A;  4QLE A;  1RX6 A;  1RX8 A;  3QLS A;  3CSE A;  4XEC X;  7DFR A;  3QYL A;  1S3W A;  1RA1 A;  3SAI A;  1DRE A;  4ELH A;  1RX2 A;  3S3V A;  2OIP A;  2FZH A;  3TD8 A;  2W9H A;  4M7U A;  1RE7 A;  1YHO A;  3QLW A;  4PSY A;  1RG7 A;  3VCO A;  3CD2 A;  1MVT A;  1RX3 A;  1BZF A;  1DG8 A;  1IA3 A;  1DHI A;  1RX9 A;  1DRH A;  3CL9 A;  1RA3 A;  1DYH A;  3K2H A;  4XT6 A;  4DPH A;  2JYB A;  4LAE X;  3UM8 A;  4Q0E A;  3SQY X;  3SA2 A;  4GH8 A;  3F8Z A;  2B3Z A;  2KGK A;  2W9S A;  4KLX A;  1ZDR A;  4XT5 A;  1DYI A;  3FYW X;  1DR2 A;  1VJ3 A;  3EEJ A;  3N0H A;  4KFJ A;  1DDS A;  4KL9 A;  2HQP A;  3GHW A;  2GD9 A;  4M6K A;  1S3Y A;  4G3M A;  3E0B A;  3KY8 A;  1AI9 A;  3R33 A;  3FS6 A;  3KJR A;  4LAG X;  1RB3 A;  3Q1H A;  1DIU A;  2OBC A;  4ELF A;  3ROA A;  1JOL A;  1PD9 A;  4KJK A;  1OHJ A;  4IXF X;  3JW5 A;  3QLZ A;  2CD2 A;  2INQ A;  4QLG A;  3FRE X;  5ECC A;  4IXG X;  3OCH A;  2CIG A;  4X5G A;  1KMS A;  4Q6A A;  3DL6 A;  4KM0 A;  5CC9 A;  5HUI A;  3NXR A;  4FHB A;  1RX5 A;  5FDA A;  3NZC X;  3NXV A;  3F8Y A;  1J3J A;  3RG9 A;  3SRQ X;  3FQO A;  2XW7 A;  5HT4 A;  3JSU A;  1DR3 A;  5HVB A;  5HQZ A;  3F0U X;  3SRW X;  1DLR A;  3TQ8 A;  1DIS A;  3M08 A;  3M09 A;  1RH3 A;  1PD8 A;  4QI9 A;  3QGT A;  4ELE A;  1E26 A;  1LY4 A;  1DG7 A;  4QJC A;  3NXX A;  2FZI A;  1RC4 A;  3F91 A;  3NZD A;  4CD2 A;  2W3W A;  3DAT A;  2G6V A;  1VDR A;  4Q67 A;  5DFR A;  4DP3 A;  4DDR A;  4LAH X;  1DLS A;  2W3B A;  3F0S X;  3FL9 A;  3EIG A;  6DFR A;  1RA8 A;  3FY8 X;  4M7V A;  4KM2 A;  1CD2 A;  3K45 A;  3JWF A;  4QJZ D;  4XT4 A;  3SH2 A;  2BLC A;  1IA2 A;  3EEM A;  1OHK A;  3K74 A;  3K47 A;  3NZ6 X;  3CLB A;  1LY3 A;  3DFR A;  1S3U A;  1DR6 A;  3NRR A;  3QLR A;  1DYR A;  3I8A X;  4H96 A;  4M6J A;  3TQ9 A;  1LUD A;  4RGC A;  4FGG A;  3IRN A;  2HXV A;  4KBN A;  4KAK A;  4X5I A;  3DG8 A;  5HVE A;  3LG4 A;  3IRM A;  1DRA A;  3L3R A;  3GI2 A;  3RO9 A;  2P4G A;  4H97 A;  4P3Q A;  4KY8 A;  2AZN A;  1DR7 A;  3SGY A;  3QLY A;  4PTH A;  1PDB A;  3NZA X;  1DF7 A;  2W3V A;  2DRC A;  2D5N A;  3S7A A;  3GHC A;  3SRU X;  1S3V A;  1DG5 A;  2BLA A;  5U27 A;  2FZJ A;  3HJ3 A;  1IA4 A;  3EX8 A;  3DL5 A;  2ANQ A;  5DXV A;  5HSR A;  3QL0 A;  1DAJ A;  2HM9 A;  3JWK A;  3FQF A;  4XT8 A;  1U71 A;  4HA9 A;  3JWM A;  3FRD X;  3SRS X;  2ITH A;  4X5H A;  3NXY A;  1RX4 A;  3KJS A;  4X5J A;  3INV A;  2W9T A;  4ECK A;  3NZ9 X;  1JOM A;  1J3I A;  3TQB A;  2C2S A;  3GYF A;  4EIG A;  5JA3 A;  3DRC A;  1U70 A;  4HOE A;  1DHJ A;  4ELB A;  4H98 A;  4IXE D;  4X5F A;  3NXO A;  3F0B X;  4DPD A;  3NU0 A;  1M7A A;  1DR5 A;  3EEK A;  4G95 A;  1DDR A;  3HBB A;  3FRB X;  4EIL A;  4P66 A;  1M78 A;  4M2X A;  1RA2 A;  2QK8 A;  3JVX A;  1U72 A;  4KEB A;  4HOF A;  2BLB A;  4HOG A;  4H95 A;  5HPB A;  4KJJ A;  4PSS A;  4FGH A;  1HFP A;  4M6L A;  1DRB A;  4NX6 A;  2L28 A;  3FQ0 A;  3FQC A;  3IA5 A;  3NTZ A;  2O7P A;  1RD7 A;  1RX1 A;  3DGA A;  5CCC A;  4P3R A;  4KY4 A;  3KGY A;  1MVS A;  1IA1 A;  1BOZ A;  3FQV A;  5HF2 X;  3D80 A;  1AOE A;  3NXT A;  1J3K A;  4XE6 X;  5HQY A;  1QZF A;  1HFQ A;  1DR1 A;  1DYJ A;  4KNE A;  3IX9 A;  3S9U A;  3QG2 A;  3ZPG A;  3JWC A;  2ZZA A;  3QYO A;  1CZ3 A;  4KJL A;  3UM6 A;  3FRF X;  4OSG A;  1RF7 A;  4PTJ A;  3D84 X;  1KMV A;  4DFR A;  1HFR A;  8DFR A;  1RB2 A;  5HI6 A;  3QLX A;  5E8Q A;  2W3A A;  1RA9 A;  2W9G A;  3NZB X;  1TDR A;  3JTW A;  3FL8 A;  3IRO A;  4G8Z X;  3FRA X;  4OR7 A;  4KD7 A;  5JG0 X;  2LF1 A;  5ECX A;  4XRB A;  1D1G A;  4I13 A;  4Q0D A;  2C2T A;  3FY9 X;  4PST A; 
#chains in the Genus database with same CATH topology
 4HA7 A;  3ZPC A;  4ELG A;  1KLK A;  3FYV X;  3FQZ A;  4EJ1 A;  1DRF A;  4NX7 A;  4PDJ A;  5HT5 A;  3I3R A;  3EEL A;  3F0Q X;  3SA1 A;  5EAJ A;  4EIZ A;  4QLF A;  5HSU A;  2DHF A;  3OAF A;  1SEJ A;  3QL3 A;  4QHV A;  3KFY A;  1RX7 A;  5U26 A;  2D0K A;  2ANO A;  4I1N A;  3TQA A;  3GHV A;  1DHF A;  4XT7 A;  1DR4 A;  2H2Q A;  5HF0 X;  1AO8 A;  3QFX A;  4P68 A;  3F0X X;  3DAU A;  4TU5 X;  4KYA A;  1JUV A;  3F0V X;  2W3M A;  3UM5 A;  4LEK X;  3JW3 A;  3SRR X;  3IA4 A;  1M79 A;  3SR5 X;  2BL9 A;  4QLE A;  1RX6 A;  1RX8 A;  3QLS A;  3CSE A;  4XEC X;  7DFR A;  3QYL A;  1S3W A;  1RA1 A;  3SAI A;  1DRE A;  4ELH A;  1RX2 A;  3S3V A;  2OIP A;  2FZH A;  3TD8 A;  2W9H A;  4M7U A;  1RE7 A;  1YHO A;  3QLW A;  4PSY A;  1RG7 A;  3VCO A;  3CD2 A;  1MVT A;  1RX3 A;  1BZF A;  1DG8 A;  1IA3 A;  1DHI A;  1RX9 A;  1DRH A;  3CL9 A;  1RA3 A;  1DYH A;  3K2H A;  4XT6 A;  4DPH A;  2JYB A;  4LAE X;  3UM8 A;  4Q0E A;  3SQY X;  3SA2 A;  4GH8 A;  3F8Z A;  2B3Z A;  2KGK A;  2W9S A;  4KLX A;  1ZDR A;  4XT5 A;  1DYI A;  3FYW X;  1DR2 A;  1VJ3 A;  3EEJ A;  3N0H A;  4KFJ A;  1DDS A;  4KL9 A;  2HQP A;  3GHW A;  2GD9 A;  4M6K A;  1S3Y A;  4G3M A;  3E0B A;  3KY8 A;  1AI9 A;  3R33 A;  3FS6 A;  3KJR A;  4LAG X;  1RB3 A;  3Q1H A;  1DIU A;  2OBC A;  4ELF A;  3ROA A;  1JOL A;  1PD9 A;  4KJK A;  1OHJ A;  4IXF X;  3JW5 A;  3QLZ A;  2CD2 A;  2INQ A;  4QLG A;  3FRE X;  5ECC A;  4IXG X;  3OCH A;  2CIG A;  4X5G A;  1KMS A;  4Q6A A;  3DL6 A;  4KM0 A;  5CC9 A;  5HUI A;  3NXR A;  4FHB A;  1RX5 A;  5FDA A;  3NZC X;  3NXV A;  3F8Y A;  1J3J A;  3RG9 A;  3SRQ X;  3FQO A;  2XW7 A;  5HT4 A;  3JSU A;  1DR3 A;  5HVB A;  5HQZ A;  3F0U X;  3SRW X;  1DLR A;  3TQ8 A;  1DIS A;  3M08 A;  3M09 A;  1RH3 A;  1PD8 A;  4QI9 A;  3QGT A;  4ELE A;  1E26 A;  1LY4 A;  1DG7 A;  4QJC A;  3NXX A;  2FZI A;  1RC4 A;  3F91 A;  3NZD A;  4CD2 A;  2W3W A;  3DAT A;  2G6V A;  1VDR A;  4Q67 A;  5DFR A;  4DP3 A;  4DDR A;  4LAH X;  1DLS A;  2W3B A;  3F0S X;  3FL9 A;  3EIG A;  6DFR A;  1RA8 A;  3FY8 X;  4M7V A;  4KM2 A;  1CD2 A;  3K45 A;  3JWF A;  4QJZ D;  4XT4 A;  3SH2 A;  2BLC A;  1IA2 A;  3EEM A;  1OHK A;  3K74 A;  3K47 A;  3NZ6 X;  3CLB A;  1LY3 A;  3DFR A;  1S3U A;  1DR6 A;  3NRR A;  3QLR A;  1DYR A;  3I8A X;  4H96 A;  4M6J A;  3TQ9 A;  1LUD A;  4RGC A;  4FGG A;  3IRN A;  2HXV A;  4KBN A;  4KAK A;  4X5I A;  3DG8 A;  5HVE A;  3LG4 A;  3IRM A;  1DRA A;  3L3R A;  3GI2 A;  3RO9 A;  2P4G A;  4H97 A;  4P3Q A;  4KY8 A;  2AZN A;  1DR7 A;  3SGY A;  3QLY A;  4PTH A;  1PDB A;  3NZA X;  1DF7 A;  2W3V A;  2DRC A;  2D5N A;  3S7A A;  3GHC A;  3SRU X;  1S3V A;  1DG5 A;  2BLA A;  5U27 A;  2FZJ A;  3HJ3 A;  1IA4 A;  3EX8 A;  3DL5 A;  2ANQ A;  5DXV A;  5HSR A;  3QL0 A;  1DAJ A;  2HM9 A;  3JWK A;  3FQF A;  4XT8 A;  1U71 A;  4HA9 A;  3JWM A;  3FRD X;  3SRS X;  2ITH A;  4X5H A;  3NXY A;  1RX4 A;  3KJS A;  4X5J A;  3INV A;  2W9T A;  4ECK A;  3NZ9 X;  1JOM A;  1J3I A;  3TQB A;  2C2S A;  3GYF A;  4EIG A;  5JA3 A;  3DRC A;  1U70 A;  4HOE A;  1DHJ A;  4ELB A;  4H98 A;  4IXE D;  4X5F A;  3NXO A;  3F0B X;  4DPD A;  3NU0 A;  1M7A A;  1DR5 A;  3EEK A;  4G95 A;  1DDR A;  3HBB A;  3FRB X;  4EIL A;  4P66 A;  1M78 A;  4M2X A;  1RA2 A;  2QK8 A;  3JVX A;  1U72 A;  4KEB A;  4HOF A;  2BLB A;  4HOG A;  4H95 A;  5HPB A;  4KJJ A;  4PSS A;  4FGH A;  1HFP A;  4M6L A;  1DRB A;  4NX6 A;  2L28 A;  3FQ0 A;  3FQC A;  3IA5 A;  3NTZ A;  2O7P A;  1RD7 A;  1RX1 A;  3DGA A;  5CCC A;  4P3R A;  4KY4 A;  3KGY A;  1MVS A;  1IA1 A;  1BOZ A;  3FQV A;  5HF2 X;  3D80 A;  1AOE A;  3NXT A;  1J3K A;  4XE6 X;  5HQY A;  1QZF A;  1HFQ A;  1DR1 A;  1DYJ A;  4KNE A;  3IX9 A;  3S9U A;  3QG2 A;  3ZPG A;  3JWC A;  2ZZA A;  3QYO A;  1CZ3 A;  4KJL A;  3UM6 A;  3FRF X;  4OSG A;  1RF7 A;  4PTJ A;  3D84 X;  1KMV A;  4DFR A;  1HFR A;  8DFR A;  1RB2 A;  5HI6 A;  3QLX A;  5E8Q A;  2W3A A;  1RA9 A;  2W9G A;  3NZB X;  1TDR A;  3JTW A;  3FL8 A;  3IRO A;  4G8Z X;  3FRA X;  4OR7 A;  4KD7 A;  5JG0 X;  2LF1 A;  5ECX A;  4XRB A;  1D1G A;  4I13 A;  4Q0D A;  2C2T A;  3FY9 X;  4PST A; 
#chains in the Genus database with same CATH homology
 4HA7 A;  3ZPC A;  4ELG A;  1KLK A;  3FYV X;  3FQZ A;  4EJ1 A;  1DRF A;  4NX7 A;  4PDJ A;  5HT5 A;  3I3R A;  3EEL A;  3F0Q X;  3SA1 A;  5EAJ A;  4EIZ A;  4QLF A;  5HSU A;  2DHF A;  3OAF A;  1SEJ A;  3QL3 A;  4QHV A;  3KFY A;  1RX7 A;  5U26 A;  2D0K A;  2ANO A;  4I1N A;  3TQA A;  3GHV A;  1DHF A;  4XT7 A;  1DR4 A;  2H2Q A;  5HF0 X;  1AO8 A;  3QFX A;  4P68 A;  3F0X X;  3DAU A;  4TU5 X;  4KYA A;  1JUV A;  3F0V X;  2W3M A;  3UM5 A;  4LEK X;  3JW3 A;  3SRR X;  3IA4 A;  1M79 A;  3SR5 X;  2BL9 A;  4QLE A;  1RX6 A;  1RX8 A;  3QLS A;  3CSE A;  4XEC X;  7DFR A;  3QYL A;  1S3W A;  1RA1 A;  3SAI A;  1DRE A;  4ELH A;  1RX2 A;  3S3V A;  2OIP A;  2FZH A;  3TD8 A;  2W9H A;  4M7U A;  1RE7 A;  1YHO A;  3QLW A;  4PSY A;  1RG7 A;  3VCO A;  3CD2 A;  1MVT A;  1RX3 A;  1BZF A;  1DG8 A;  1IA3 A;  1DHI A;  1RX9 A;  1DRH A;  3CL9 A;  1RA3 A;  1DYH A;  3K2H A;  4XT6 A;  4DPH A;  2JYB A;  4LAE X;  3UM8 A;  4Q0E A;  3SQY X;  3SA2 A;  4GH8 A;  3F8Z A;  2B3Z A;  2KGK A;  2W9S A;  4KLX A;  1ZDR A;  4XT5 A;  1DYI A;  3FYW X;  1DR2 A;  1VJ3 A;  3EEJ A;  3N0H A;  4KFJ A;  1DDS A;  4KL9 A;  2HQP A;  3GHW A;  2GD9 A;  4M6K A;  1S3Y A;  4G3M A;  3E0B A;  3KY8 A;  1AI9 A;  3R33 A;  3FS6 A;  3KJR A;  4LAG X;  1RB3 A;  3Q1H A;  1DIU A;  2OBC A;  4ELF A;  3ROA A;  1JOL A;  1PD9 A;  4KJK A;  1OHJ A;  4IXF X;  3JW5 A;  3QLZ A;  2CD2 A;  2INQ A;  4QLG A;  3FRE X;  5ECC A;  4IXG X;  3OCH A;  2CIG A;  4X5G A;  1KMS A;  4Q6A A;  3DL6 A;  4KM0 A;  5CC9 A;  5HUI A;  3NXR A;  4FHB A;  1RX5 A;  5FDA A;  3NZC X;  3NXV A;  3F8Y A;  1J3J A;  3RG9 A;  3SRQ X;  3FQO A;  2XW7 A;  5HT4 A;  3JSU A;  1DR3 A;  5HVB A;  5HQZ A;  3F0U X;  3SRW X;  1DLR A;  3TQ8 A;  1DIS A;  3M08 A;  3M09 A;  1RH3 A;  1PD8 A;  4QI9 A;  3QGT A;  4ELE A;  1E26 A;  1LY4 A;  1DG7 A;  4QJC A;  3NXX A;  2FZI A;  1RC4 A;  3F91 A;  3NZD A;  4CD2 A;  2W3W A;  3DAT A;  2G6V A;  1VDR A;  4Q67 A;  5DFR A;  4DP3 A;  4DDR A;  4LAH X;  1DLS A;  2W3B A;  3F0S X;  3FL9 A;  3EIG A;  6DFR A;  1RA8 A;  3FY8 X;  4M7V A;  4KM2 A;  1CD2 A;  3K45 A;  3JWF A;  4QJZ D;  4XT4 A;  3SH2 A;  2BLC A;  1IA2 A;  3EEM A;  1OHK A;  3K74 A;  3K47 A;  3NZ6 X;  3CLB A;  1LY3 A;  3DFR A;  1S3U A;  1DR6 A;  3NRR A;  3QLR A;  1DYR A;  3I8A X;  4H96 A;  4M6J A;  3TQ9 A;  1LUD A;  4RGC A;  4FGG A;  3IRN A;  2HXV A;  4KBN A;  4KAK A;  4X5I A;  3DG8 A;  5HVE A;  3LG4 A;  3IRM A;  1DRA A;  3L3R A;  3GI2 A;  3RO9 A;  2P4G A;  4H97 A;  4P3Q A;  4KY8 A;  2AZN A;  1DR7 A;  3SGY A;  3QLY A;  4PTH A;  1PDB A;  3NZA X;  1DF7 A;  2W3V A;  2DRC A;  2D5N A;  3S7A A;  3GHC A;  3SRU X;  1S3V A;  1DG5 A;  2BLA A;  5U27 A;  2FZJ A;  3HJ3 A;  1IA4 A;  3EX8 A;  3DL5 A;  2ANQ A;  5DXV A;  5HSR A;  3QL0 A;  1DAJ A;  2HM9 A;  3JWK A;  3FQF A;  4XT8 A;  1U71 A;  4HA9 A;  3JWM A;  3FRD X;  3SRS X;  2ITH A;  4X5H A;  3NXY A;  1RX4 A;  3KJS A;  4X5J A;  3INV A;  2W9T A;  4ECK A;  3NZ9 X;  1JOM A;  1J3I A;  3TQB A;  2C2S A;  3GYF A;  4EIG A;  5JA3 A;  3DRC A;  1U70 A;  4HOE A;  1DHJ A;  4ELB A;  4H98 A;  4IXE D;  4X5F A;  3NXO A;  3F0B X;  4DPD A;  3NU0 A;  1M7A A;  1DR5 A;  3EEK A;  4G95 A;  1DDR A;  3HBB A;  3FRB X;  4EIL A;  4P66 A;  1M78 A;  4M2X A;  1RA2 A;  2QK8 A;  3JVX A;  1U72 A;  4KEB A;  4HOF A;  2BLB A;  4HOG A;  4H95 A;  5HPB A;  4KJJ A;  4PSS A;  4FGH A;  1HFP A;  4M6L A;  1DRB A;  4NX6 A;  2L28 A;  3FQ0 A;  3FQC A;  3IA5 A;  3NTZ A;  2O7P A;  1RD7 A;  1RX1 A;  3DGA A;  5CCC A;  4P3R A;  4KY4 A;  3KGY A;  1MVS A;  1IA1 A;  1BOZ A;  3FQV A;  5HF2 X;  3D80 A;  1AOE A;  3NXT A;  1J3K A;  4XE6 X;  5HQY A;  1QZF A;  1HFQ A;  1DR1 A;  1DYJ A;  4KNE A;  3IX9 A;  3S9U A;  3QG2 A;  3ZPG A;  3JWC A;  2ZZA A;  3QYO A;  1CZ3 A;  4KJL A;  3UM6 A;  3FRF X;  4OSG A;  1RF7 A;  4PTJ A;  3D84 X;  1KMV A;  4DFR A;  1HFR A;  8DFR A;  1RB2 A;  5HI6 A;  3QLX A;  5E8Q A;  2W3A A;  1RA9 A;  2W9G A;  3NZB X;  1TDR A;  3JTW A;  3FL8 A;  3IRO A;  4G8Z X;  3FRA X;  4OR7 A;  4KD7 A;  5JG0 X;  2LF1 A;  5ECX A;  4XRB A;  1D1G A;  4I13 A;  4Q0D A;  2C2T A;  3FY9 X;  4PST A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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