1DREA

Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (oxidized form)
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 43
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1996-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1dreA00
3E0BA 1DR5A 3RG9A 1BZFA 4QLEA 3QG2A 5CCCA 4EIZA 3EX8A 1DDRA 3GYFA 4PDJA 1DYRA 1U71A 3Q1HA 5FDAA 7DFRA 3OCHA 1IA1A 3GHCA 4X5IA 3SA2A 4QI9A 2FZJA 1DR3A 3F8YA 4FGHA 3FQCA 3SRRX 2P4GA 3QGTA 2W9HA 3N0HA 3QLZA 2HXVA 4DDRA 2L28A 3FQ0A 5HVEA 3EEMA 5HVBA 1RA8A 3DFRA 4X5GA 1DHIA 4I13A 1RX9A 3K2HA 4XECX 4IXGX 3NXRA 1DRAA 4ELEA 1DYJA 1S3WA 3JVXA 3NU0A 3JTWA 2AZNA 3ZPCA 2G6VA 4XT8A 1RG7A 3DAUA 3IX9A 4CD2A 2BLCA 4M6KA 3S3VA 1M7AA 4KJJA 4IXFX 1IA4A 1M79A 1J3JA 3FQOA 3F0SX 3DGAA 3ROAA 3I3RA 2OBCA 1AO8A 4M7VA 3JWCA 1RA3A 3F91A 1JOLA 5U27A 4KFJA 2BLBA 1DYIA 3KJSA 4G95A 4Q0DA 1RB2A 3FQFA 3CLBA 3JSUA 3FRDX 1RA9A 2W9GA 4PTHA 3FRBX 3FQVA 4X5JA 5HUIA 4RGCA 4EIGA 1PD8A 4FHBA 4QHVA 1RX7A 4H97A 4TU5X 1RX8A 1ZDRA 2XW7A 3EEKA 5U26A 1DHJA 3JWFA 2OIPA 3GHWA 3NZBX 1DR7A 1PD9A 3FL9A 3JWMA 4XT7A 1LY4A 1PDBA 3HJ3A 4XE6X 4NX6A 3KFYA 3NZAX 3CD2A 4P68A 4XT5A 3QLSA 3ZPGA 1RX3A 4OR7A 1DLRA 3SQYX 3QLYA 4NX7A 4KBNA 1DDSA 1LUDA 3SGYA 5HT4A 1DR6A 2INQA 4H96A 3SRSX 3IROA 5HQYA 2ANOA 4HA9A 4G8ZX 4DFRA 1RH3A 1LY3A 1DREA 3S7AA 3NZDA 3I8AX 4ECKA 2ZZAA 4KAKA 3SH2A 1HFPA 4KJKA 2W3MA 3CL9A 3UM5A 1HFQA 4PSTA 1U72A 1DRBA 1MVTA 3TQAA 4EJ1A 1AI9A 1DF7A 4LAHX 3F0XX 2CIGA 4QJZD 2BLAA 8DFRA 3M08A 3FRFX 5HT5A 1DR1A 3INVA 1DLSA 3QLXA 4X5HA 5E8QA 1RX2A 3F0UX 3IA5A 1RX5A 1D1GA 3TQ9A 1DR4A 1DISA 1OHKA 3DL6A 1TDRA 1E26A 1QZFA 2LF1A 4ELHA 4H98A 3NXXA 3NXOA 4KL9A 4XT4A 4H95A 4KNEA 3NTZA 3FQZA 2ANQA 3QL3A 4LEKX 3K45A 4M6JA 3UM8A 3FREX 3DRCA 2DHFA 4I1NA 4M2XA 2FZHA 3FL8A 3VCOA 3GI2A 4ELGA 2CD2A 2ITHA 4KLXA 5CC9A 4P3RA 3GHVA 1JOMA 4GH8A 1HFRA 2FZIA 1IA3A 3LG4A 1DG8A 4FGGA 4XT6A 4QLFA 5DXVA 3FRAX 3FYWX 4KYAA 1J3IA 4HOEA 5HF2X 3M09A 3FS6A 3KGYA 1RB3A 2W3AA 3D80A 3DG8A 4ELFA 2GD9A 3QYOA 2H2QA 1YHOA 4KD7A 3SAIA 4XRBA 1VDRA 2QK8A 2W3VA 1RE7A 3SA1A 4KY8A 4ELBA 3QLRA 5ECCA 4KM0A 3SRUX 1CZ3A 3EIGA 3K74A 3F0BX 1RF7A 2C2SA 4X5FA 4KM2A 1CD2A 1RA2A 3QLWA 3EEJA 2W3WA 3UM6A 3NXVA 4PSSA 1IA2A 6DFRA 2HQPA 2KGKA 4DPHA 3NXTA 1DRFA 3SR5X 1DYHA 3DATA 5DFRA 1MVSA 1RX1A 4LAEX 3K47A 3IA4A 3IRNA 5EAJA 5HF0X 3D84X 3EELA 2C2TA 3KY8A 1M78A 4P66A 4Q0EA 1DIUA 4DPDA 4QJCA 3IRMA 1DHFA 3JWKA 5HPBA 4QLGA 3FY9X 3F0QX 1AOEA 4Q67A 1J3KA 2DRCA 3F0VX 1SEJA 1RX4A 5ECXA 5JG0X 4PSYA 3SRWX 1DG7A 3JW3A 3CSEA 2O7PA 5JA3A 1KMSA 1VJ3A 3FY8X 5HQZA 1RX6A 3NZCX 1RA1A 4IXED 4Q6AA 4DP3A 1OHJA 1U70A 2D5NA 4HA7A 1KMVA 1DRHA 4OSGA 4KY4A 5HSUA 3NXYA 2JYBA 1DR2A 3R33A 2W9TA 3DL5A 4M6LA 1JUVA 3L3RA 3S9UA 1BOZA 1KLKA 1RD7A 3HBBA 3NZ9X 1S3VA 2BL9A 4HOGA 3TD8A 1DG5A 3OAFA 4KJLA 3FYVX 4HOFA 2W3BA 1S3YA 3NZ6X 4P3QA 3KJRA 3QYLA 3TQ8A 3JW5A 3RO9A 4M7UA 5HSRA 3SRQX 2B3ZA 4G3MA 1RC4A 3QFXA 3QL0A 4PTJA 4EILA 2W9SA 2D0KA 5HI6A 2HM9A 3TQBA 4LAGX 1S3UA 3F8ZA 4KEBA 1DAJA 3NRRA
chains in the Genus database with same CATH superfamily
3E0BA 1DR5A 3RG9A 1BZFA 4QLEA 3QG2A 5CCCA 4EIZA 3EX8A 1DDRA 3GYFA 4PDJA 1DYRA 1U71A 3Q1HA 5FDAA 7DFRA 3OCHA 1IA1A 3GHCA 4X5IA 3SA2A 4QI9A 2FZJA 1DR3A 3F8YA 4FGHA 3FQCA 3SRRX 2P4GA 3QGTA 2W9HA 3N0HA 3QLZA 2HXVA 4DDRA 2L28A 3FQ0A 5HVEA 3EEMA 5HVBA 1RA8A 3DFRA 4X5GA 1DHIA 4I13A 1RX9A 3K2HA 4XECX 4IXGX 3NXRA 1DRAA 4ELEA 1DYJA 1S3WA 3JVXA 3NU0A 3JTWA 2AZNA 3ZPCA 2G6VA 4XT8A 1RG7A 3DAUA 3IX9A 4CD2A 2BLCA 4M6KA 3S3VA 1M7AA 4KJJA 4IXFX 1IA4A 1M79A 1J3JA 3FQOA 3F0SX 3DGAA 3ROAA 3I3RA 2OBCA 1AO8A 4M7VA 3JWCA 1RA3A 3F91A 1JOLA 5U27A 4KFJA 2BLBA 1DYIA 3KJSA 4G95A 4Q0DA 1RB2A 3FQFA 3CLBA 3JSUA 3FRDX 1RA9A 2W9GA 4PTHA 3FRBX 3FQVA 4X5JA 5HUIA 4RGCA 4EIGA 1PD8A 4FHBA 4QHVA 1RX7A 4H97A 4TU5X 1RX8A 1ZDRA 2XW7A 3EEKA 5U26A 1DHJA 3JWFA 2OIPA 3GHWA 3NZBX 1DR7A 1PD9A 3FL9A 3JWMA 4XT7A 1LY4A 1PDBA 3HJ3A 4XE6X 4NX6A 3KFYA 3NZAX 3CD2A 4P68A 4XT5A 3QLSA 3ZPGA 1RX3A 4OR7A 1DLRA 3SQYX 3QLYA 4NX7A 4KBNA 1DDSA 1LUDA 3SGYA 5HT4A 1DR6A 2INQA 4H96A 3SRSX 3IROA 5HQYA 2ANOA 4HA9A 4G8ZX 4DFRA 1RH3A 1LY3A 1DREA 3S7AA 3NZDA 3I8AX 4ECKA 2ZZAA 4KAKA 3SH2A 1HFPA 4KJKA 2W3MA 3CL9A 3UM5A 1HFQA 4PSTA 1U72A 1DRBA 1MVTA 3TQAA 4EJ1A 1AI9A 1DF7A 4LAHX 3F0XX 2CIGA 4QJZD 2BLAA 8DFRA 3M08A 3FRFX 5HT5A 1DR1A 3INVA 1DLSA 3QLXA 4X5HA 5E8QA 1RX2A 3F0UX 3IA5A 1RX5A 1D1GA 3TQ9A 1DR4A 1DISA 1OHKA 3DL6A 1TDRA 1E26A 1QZFA 2LF1A 4ELHA 4H98A 3NXXA 3NXOA 4KL9A 4XT4A 4H95A 4KNEA 3NTZA 3FQZA 2ANQA 3QL3A 4LEKX 3K45A 4M6JA 3UM8A 3FREX 3DRCA 2DHFA 4I1NA 4M2XA 2FZHA 3FL8A 3VCOA 3GI2A 4ELGA 2CD2A 2ITHA 4KLXA 5CC9A 4P3RA 3GHVA 1JOMA 4GH8A 1HFRA 2FZIA 1IA3A 3LG4A 1DG8A 4FGGA 4XT6A 4QLFA 5DXVA 3FRAX 3FYWX 4KYAA 1J3IA 4HOEA 5HF2X 3M09A 3FS6A 3KGYA 1RB3A 2W3AA 3D80A 3DG8A 4ELFA 2GD9A 3QYOA 2H2QA 1YHOA 4KD7A 3SAIA 4XRBA 1VDRA 2QK8A 2W3VA 1RE7A 3SA1A 4KY8A 4ELBA 3QLRA 5ECCA 4KM0A 3SRUX 1CZ3A 3EIGA 3K74A 3F0BX 1RF7A 2C2SA 4X5FA 4KM2A 1CD2A 1RA2A 3QLWA 3EEJA 2W3WA 3UM6A 3NXVA 4PSSA 1IA2A 6DFRA 2HQPA 2KGKA 4DPHA 3NXTA 1DRFA 3SR5X 1DYHA 3DATA 5DFRA 1MVSA 1RX1A 4LAEX 3K47A 3IA4A 3IRNA 5EAJA 5HF0X 3D84X 3EELA 2C2TA 3KY8A 1M78A 4P66A 4Q0EA 1DIUA 4DPDA 4QJCA 3IRMA 1DHFA 3JWKA 5HPBA 4QLGA 3FY9X 3F0QX 1AOEA 4Q67A 1J3KA 2DRCA 3F0VX 1SEJA 1RX4A 5ECXA 5JG0X 4PSYA 3SRWX 1DG7A 3JW3A 3CSEA 2O7PA 5JA3A 1KMSA 1VJ3A 3FY8X 5HQZA 1RX6A 3NZCX 1RA1A 4IXED 4Q6AA 4DP3A 1OHJA 1U70A 2D5NA 4HA7A 1KMVA 1DRHA 4OSGA 4KY4A 5HSUA 3NXYA 2JYBA 1DR2A 3R33A 2W9TA 3DL5A 4M6LA 1JUVA 3L3RA 3S9UA 1BOZA 1KLKA 1RD7A 3HBBA 3NZ9X 1S3VA 2BL9A 4HOGA 3TD8A 1DG5A 3OAFA 4KJLA 3FYVX 4HOFA 2W3BA 1S3YA 3NZ6X 4P3QA 3KJRA 3QYLA 3TQ8A 3JW5A 3RO9A 4M7UA 5HSRA 3SRQX 2B3ZA 4G3MA 1RC4A 3QFXA 3QL0A 4PTJA 4EILA 2W9SA 2D0KA 5HI6A 2HM9A 3TQBA 4LAGX 1S3UA 3F8ZA 4KEBA 1DAJA 3NRRA
chains in the Genus database with same CATH topology
3E0BA 1DR5A 3RG9A 1BZFA 4QLEA 3QG2A 5CCCA 4EIZA 3EX8A 1DDRA 3GYFA 4PDJA 1DYRA 1U71A 3Q1HA 5FDAA 7DFRA 3OCHA 1IA1A 3GHCA 4X5IA 3SA2A 4QI9A 2FZJA 1DR3A 3F8YA 4FGHA 3FQCA 3SRRX 2P4GA 3QGTA 2W9HA 3N0HA 3QLZA 2HXVA 4DDRA 2L28A 3FQ0A 5HVEA 3EEMA 5HVBA 1RA8A 3DFRA 4X5GA 1DHIA 4I13A 1RX9A 3K2HA 4XECX 4IXGX 3NXRA 1DRAA 4ELEA 1DYJA 1S3WA 3JVXA 3NU0A 3JTWA 2AZNA 3ZPCA 2G6VA 4XT8A 1RG7A 3DAUA 3IX9A 4CD2A 2BLCA 4M6KA 3S3VA 1M7AA 4KJJA 4IXFX 1IA4A 1M79A 1J3JA 3FQOA 3F0SX 3DGAA 3ROAA 3I3RA 2OBCA 1AO8A 4M7VA 3JWCA 1RA3A 3F91A 1JOLA 5U27A 4KFJA 2BLBA 1DYIA 3KJSA 4G95A 4Q0DA 1RB2A 3FQFA 3CLBA 3JSUA 3FRDX 1RA9A 2W9GA 4PTHA 3FRBX 3FQVA 4X5JA 5HUIA 4RGCA 4EIGA 1PD8A 4FHBA 4QHVA 1RX7A 4H97A 4TU5X 1RX8A 1ZDRA 2XW7A 3EEKA 5U26A 1DHJA 3JWFA 2OIPA 3GHWA 3NZBX 1DR7A 1PD9A 3FL9A 3JWMA 4XT7A 1LY4A 1PDBA 3HJ3A 4XE6X 4NX6A 3KFYA 3NZAX 3CD2A 4P68A 4XT5A 3QLSA 3ZPGA 1RX3A 4OR7A 1DLRA 3SQYX 3QLYA 4NX7A 4KBNA 1DDSA 1LUDA 3SGYA 5HT4A 1DR6A 2INQA 4H96A 3SRSX 3IROA 5HQYA 2ANOA 4HA9A 4G8ZX 4DFRA 1RH3A 1LY3A 1DREA 3S7AA 3NZDA 3I8AX 4ECKA 2ZZAA 4KAKA 3SH2A 1HFPA 4KJKA 2W3MA 3CL9A 3UM5A 1HFQA 4PSTA 1U72A 1DRBA 1MVTA 3TQAA 4EJ1A 1AI9A 1DF7A 4LAHX 3F0XX 2CIGA 4QJZD 2BLAA 8DFRA 3M08A 3FRFX 5HT5A 1DR1A 3INVA 1DLSA 3QLXA 4X5HA 5E8QA 1RX2A 3F0UX 3IA5A 1RX5A 1D1GA 3TQ9A 1DR4A 1DISA 1OHKA 3DL6A 1TDRA 1E26A 1QZFA 2LF1A 4ELHA 4H98A 3NXXA 3NXOA 4KL9A 4XT4A 4H95A 4KNEA 3NTZA 3FQZA 2ANQA 3QL3A 4LEKX 3K45A 4M6JA 3UM8A 3FREX 3DRCA 2DHFA 4I1NA 4M2XA 2FZHA 3FL8A 3VCOA 3GI2A 4ELGA 2CD2A 2ITHA 4KLXA 5CC9A 4P3RA 3GHVA 1JOMA 4GH8A 1HFRA 2FZIA 1IA3A 3LG4A 1DG8A 4FGGA 4XT6A 4QLFA 5DXVA 3FRAX 3FYWX 4KYAA 1J3IA 4HOEA 5HF2X 3M09A 3FS6A 3KGYA 1RB3A 2W3AA 3D80A 3DG8A 4ELFA 2GD9A 3QYOA 2H2QA 1YHOA 4KD7A 3SAIA 4XRBA 1VDRA 2QK8A 2W3VA 1RE7A 3SA1A 4KY8A 4ELBA 3QLRA 5ECCA 4KM0A 3SRUX 1CZ3A 3EIGA 3K74A 3F0BX 1RF7A 2C2SA 4X5FA 4KM2A 1CD2A 1RA2A 3QLWA 3EEJA 2W3WA 3UM6A 3NXVA 4PSSA 1IA2A 6DFRA 2HQPA 2KGKA 4DPHA 3NXTA 1DRFA 3SR5X 1DYHA 3DATA 5DFRA 1MVSA 1RX1A 4LAEX 3K47A 3IA4A 3IRNA 5EAJA 5HF0X 3D84X 3EELA 2C2TA 3KY8A 1M78A 4P66A 4Q0EA 1DIUA 4DPDA 4QJCA 3IRMA 1DHFA 3JWKA 5HPBA 4QLGA 3FY9X 3F0QX 1AOEA 4Q67A 1J3KA 2DRCA 3F0VX 1SEJA 1RX4A 5ECXA 5JG0X 4PSYA 3SRWX 1DG7A 3JW3A 3CSEA 2O7PA 5JA3A 1KMSA 1VJ3A 3FY8X 5HQZA 1RX6A 3NZCX 1RA1A 4IXED 4Q6AA 4DP3A 1OHJA 1U70A 2D5NA 4HA7A 1KMVA 1DRHA 4OSGA 4KY4A 5HSUA 3NXYA 2JYBA 1DR2A 3R33A 2W9TA 3DL5A 4M6LA 1JUVA 3L3RA 3S9UA 1BOZA 1KLKA 1RD7A 3HBBA 3NZ9X 1S3VA 2BL9A 4HOGA 3TD8A 1DG5A 3OAFA 4KJLA 3FYVX 4HOFA 2W3BA 1S3YA 3NZ6X 4P3QA 3KJRA 3QYLA 3TQ8A 3JW5A 3RO9A 4M7UA 5HSRA 3SRQX 2B3ZA 4G3MA 1RC4A 3QFXA 3QL0A 4PTJA 4EILA 2W9SA 2D0KA 5HI6A 2HM9A 3TQBA 4LAGX 1S3UA 3F8ZA 4KEBA 1DAJA 3NRRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E0B A;  1DR5 A;  3RG9 A;  1BZF A;  4QLE A;  3QG2 A;  5CCC A;  4EIZ A;  3EX8 A;  1DDR A;  3GYF A;  4PDJ A;  1DYR A;  1U71 A;  3Q1H A;  5FDA A;  7DFR A;  3OCH A;  1IA1 A;  3GHC A;  4X5I A;  3SA2 A;  4QI9 A;  2FZJ A;  1DR3 A;  3F8Y A;  4FGH A;  3FQC A;  3SRR X;  2P4G A;  3QGT A;  2W9H A;  3N0H A;  3QLZ A;  2HXV A;  4DDR A;  2L28 A;  3FQ0 A;  5HVE A;  3EEM A;  5HVB A;  1RA8 A;  3DFR A;  4X5G A;  1DHI A;  4I13 A;  1RX9 A;  3K2H A;  4XEC X;  4IXG X;  3NXR A;  1DRA A;  4ELE A;  1DYJ A;  1S3W A;  3JVX A;  3NU0 A;  3JTW A;  2AZN A;  3ZPC A;  2G6V A;  4XT8 A;  1RG7 A;  3DAU A;  3IX9 A;  4CD2 A;  2BLC A;  4M6K A;  3S3V A;  1M7A A;  4KJJ A;  4IXF X;  1IA4 A;  1M79 A;  1J3J A;  3FQO A;  3F0S X;  3DGA A;  3ROA A;  3I3R A;  2OBC A;  1AO8 A;  4M7V A;  3JWC A;  1RA3 A;  3F91 A;  1JOL A;  5U27 A;  4KFJ A;  2BLB A;  1DYI A;  3KJS A;  4G95 A;  4Q0D A;  1RB2 A;  3FQF A;  3CLB A;  3JSU A;  3FRD X;  1RA9 A;  2W9G A;  4PTH A;  3FRB X;  3FQV A;  4X5J A;  5HUI A;  4RGC A;  4EIG A;  1PD8 A;  4FHB A;  4QHV A;  1RX7 A;  4H97 A;  4TU5 X;  1RX8 A;  1ZDR A;  2XW7 A;  3EEK A;  5U26 A;  1DHJ A;  3JWF A;  2OIP A;  3GHW A;  3NZB X;  1DR7 A;  1PD9 A;  3FL9 A;  3JWM A;  4XT7 A;  1LY4 A;  1PDB A;  3HJ3 A;  4XE6 X;  4NX6 A;  3KFY A;  3NZA X;  3CD2 A;  4P68 A;  4XT5 A;  3QLS A;  3ZPG A;  1RX3 A;  4OR7 A;  1DLR A;  3SQY X;  3QLY A;  4NX7 A;  4KBN A;  1DDS A;  1LUD A;  3SGY A;  5HT4 A;  1DR6 A;  2INQ A;  4H96 A;  3SRS X;  3IRO A;  5HQY A;  2ANO A;  4HA9 A;  4G8Z X;  4DFR A;  1RH3 A;  1LY3 A;  1DRE A;  3S7A A;  3NZD A;  3I8A X;  4ECK A;  2ZZA A;  4KAK A;  3SH2 A;  1HFP A;  4KJK A;  2W3M A;  3CL9 A;  3UM5 A;  1HFQ A;  4PST A;  1U72 A;  1DRB A;  1MVT A;  3TQA A;  4EJ1 A;  1AI9 A;  1DF7 A;  4LAH X;  3F0X X;  2CIG A;  4QJZ D;  2BLA A;  8DFR A;  3M08 A;  3FRF X;  5HT5 A;  1DR1 A;  3INV A;  1DLS A;  3QLX A;  4X5H A;  5E8Q A;  1RX2 A;  3F0U X;  3IA5 A;  1RX5 A;  1D1G A;  3TQ9 A;  1DR4 A;  1DIS A;  1OHK A;  3DL6 A;  1TDR A;  1E26 A;  1QZF A;  2LF1 A;  4ELH A;  4H98 A;  3NXX A;  3NXO A;  4KL9 A;  4XT4 A;  4H95 A;  4KNE A;  3NTZ A;  3FQZ A;  2ANQ A;  3QL3 A;  4LEK X;  3K45 A;  4M6J A;  3UM8 A;  3FRE X;  3DRC A;  2DHF A;  4I1N A;  4M2X A;  2FZH A;  3FL8 A;  3VCO A;  3GI2 A;  4ELG A;  2CD2 A;  2ITH A;  4KLX A;  5CC9 A;  4P3R A;  3GHV A;  1JOM A;  4GH8 A;  1HFR A;  2FZI A;  1IA3 A;  3LG4 A;  1DG8 A;  4FGG A;  4XT6 A;  4QLF A;  5DXV A;  3FRA X;  3FYW X;  4KYA A;  1J3I A;  4HOE A;  5HF2 X;  3M09 A;  3FS6 A;  3KGY A;  1RB3 A;  2W3A A;  3D80 A;  3DG8 A;  4ELF A;  2GD9 A;  3QYO A;  2H2Q A;  1YHO A;  4KD7 A;  3SAI A;  4XRB A;  1VDR A;  2QK8 A;  2W3V A;  1RE7 A;  3SA1 A;  4KY8 A;  4ELB A;  3QLR A;  5ECC A;  4KM0 A;  3SRU X;  1CZ3 A;  3EIG A;  3K74 A;  3F0B X;  1RF7 A;  2C2S A;  4X5F A;  4KM2 A;  1CD2 A;  1RA2 A;  3QLW A;  3EEJ A;  2W3W A;  3UM6 A;  3NXV A;  4PSS A;  1IA2 A;  6DFR A;  2HQP A;  2KGK A;  4DPH A;  3NXT A;  1DRF A;  3SR5 X;  1DYH A;  3DAT A;  5DFR A;  1MVS A;  1RX1 A;  4LAE X;  3K47 A;  3IA4 A;  3IRN A;  5EAJ A;  5HF0 X;  3D84 X;  3EEL A;  2C2T A;  3KY8 A;  1M78 A;  4P66 A;  4Q0E A;  1DIU A;  4DPD A;  4QJC A;  3IRM A;  1DHF A;  3JWK A;  5HPB A;  4QLG A;  3FY9 X;  3F0Q X;  1AOE A;  4Q67 A;  1J3K A;  2DRC A;  3F0V X;  1SEJ A;  1RX4 A;  5ECX A;  5JG0 X;  4PSY A;  3SRW X;  1DG7 A;  3JW3 A;  3CSE A;  2O7P A;  5JA3 A;  1KMS A;  1VJ3 A;  3FY8 X;  5HQZ A;  1RX6 A;  3NZC X;  1RA1 A;  4IXE D;  4Q6A A;  4DP3 A;  1OHJ A;  1U70 A;  2D5N A;  4HA7 A;  1KMV A;  1DRH A;  4OSG A;  4KY4 A;  5HSU A;  3NXY A;  2JYB A;  1DR2 A;  3R33 A;  2W9T A;  3DL5 A;  4M6L A;  1JUV A;  3L3R A;  3S9U A;  1BOZ A;  1KLK A;  1RD7 A;  3HBB A;  3NZ9 X;  1S3V A;  2BL9 A;  4HOG A;  3TD8 A;  1DG5 A;  3OAF A;  4KJL A;  3FYV X;  4HOF A;  2W3B A;  1S3Y A;  3NZ6 X;  4P3Q A;  3KJR A;  3QYL A;  3TQ8 A;  3JW5 A;  3RO9 A;  4M7U A;  5HSR A;  3SRQ X;  2B3Z A;  4G3M A;  1RC4 A;  3QFX A;  3QL0 A;  4PTJ A;  4EIL A;  2W9S A;  2D0K A;  5HI6 A;  2HM9 A;  3TQB A;  4LAG X;  1S3U A;  3F8Z A;  4KEB A;  1DAJ A;  3NRR A; 
#chains in the Genus database with same CATH topology
 3E0B A;  1DR5 A;  3RG9 A;  1BZF A;  4QLE A;  3QG2 A;  5CCC A;  4EIZ A;  3EX8 A;  1DDR A;  3GYF A;  4PDJ A;  1DYR A;  1U71 A;  3Q1H A;  5FDA A;  7DFR A;  3OCH A;  1IA1 A;  3GHC A;  4X5I A;  3SA2 A;  4QI9 A;  2FZJ A;  1DR3 A;  3F8Y A;  4FGH A;  3FQC A;  3SRR X;  2P4G A;  3QGT A;  2W9H A;  3N0H A;  3QLZ A;  2HXV A;  4DDR A;  2L28 A;  3FQ0 A;  5HVE A;  3EEM A;  5HVB A;  1RA8 A;  3DFR A;  4X5G A;  1DHI A;  4I13 A;  1RX9 A;  3K2H A;  4XEC X;  4IXG X;  3NXR A;  1DRA A;  4ELE A;  1DYJ A;  1S3W A;  3JVX A;  3NU0 A;  3JTW A;  2AZN A;  3ZPC A;  2G6V A;  4XT8 A;  1RG7 A;  3DAU A;  3IX9 A;  4CD2 A;  2BLC A;  4M6K A;  3S3V A;  1M7A A;  4KJJ A;  4IXF X;  1IA4 A;  1M79 A;  1J3J A;  3FQO A;  3F0S X;  3DGA A;  3ROA A;  3I3R A;  2OBC A;  1AO8 A;  4M7V A;  3JWC A;  1RA3 A;  3F91 A;  1JOL A;  5U27 A;  4KFJ A;  2BLB A;  1DYI A;  3KJS A;  4G95 A;  4Q0D A;  1RB2 A;  3FQF A;  3CLB A;  3JSU A;  3FRD X;  1RA9 A;  2W9G A;  4PTH A;  3FRB X;  3FQV A;  4X5J A;  5HUI A;  4RGC A;  4EIG A;  1PD8 A;  4FHB A;  4QHV A;  1RX7 A;  4H97 A;  4TU5 X;  1RX8 A;  1ZDR A;  2XW7 A;  3EEK A;  5U26 A;  1DHJ A;  3JWF A;  2OIP A;  3GHW A;  3NZB X;  1DR7 A;  1PD9 A;  3FL9 A;  3JWM A;  4XT7 A;  1LY4 A;  1PDB A;  3HJ3 A;  4XE6 X;  4NX6 A;  3KFY A;  3NZA X;  3CD2 A;  4P68 A;  4XT5 A;  3QLS A;  3ZPG A;  1RX3 A;  4OR7 A;  1DLR A;  3SQY X;  3QLY A;  4NX7 A;  4KBN A;  1DDS A;  1LUD A;  3SGY A;  5HT4 A;  1DR6 A;  2INQ A;  4H96 A;  3SRS X;  3IRO A;  5HQY A;  2ANO A;  4HA9 A;  4G8Z X;  4DFR A;  1RH3 A;  1LY3 A;  1DRE A;  3S7A A;  3NZD A;  3I8A X;  4ECK A;  2ZZA A;  4KAK A;  3SH2 A;  1HFP A;  4KJK A;  2W3M A;  3CL9 A;  3UM5 A;  1HFQ A;  4PST A;  1U72 A;  1DRB A;  1MVT A;  3TQA A;  4EJ1 A;  1AI9 A;  1DF7 A;  4LAH X;  3F0X X;  2CIG A;  4QJZ D;  2BLA A;  8DFR A;  3M08 A;  3FRF X;  5HT5 A;  1DR1 A;  3INV A;  1DLS A;  3QLX A;  4X5H A;  5E8Q A;  1RX2 A;  3F0U X;  3IA5 A;  1RX5 A;  1D1G A;  3TQ9 A;  1DR4 A;  1DIS A;  1OHK A;  3DL6 A;  1TDR A;  1E26 A;  1QZF A;  2LF1 A;  4ELH A;  4H98 A;  3NXX A;  3NXO A;  4KL9 A;  4XT4 A;  4H95 A;  4KNE A;  3NTZ A;  3FQZ A;  2ANQ A;  3QL3 A;  4LEK X;  3K45 A;  4M6J A;  3UM8 A;  3FRE X;  3DRC A;  2DHF A;  4I1N A;  4M2X A;  2FZH A;  3FL8 A;  3VCO A;  3GI2 A;  4ELG A;  2CD2 A;  2ITH A;  4KLX A;  5CC9 A;  4P3R A;  3GHV A;  1JOM A;  4GH8 A;  1HFR A;  2FZI A;  1IA3 A;  3LG4 A;  1DG8 A;  4FGG A;  4XT6 A;  4QLF A;  5DXV A;  3FRA X;  3FYW X;  4KYA A;  1J3I A;  4HOE A;  5HF2 X;  3M09 A;  3FS6 A;  3KGY A;  1RB3 A;  2W3A A;  3D80 A;  3DG8 A;  4ELF A;  2GD9 A;  3QYO A;  2H2Q A;  1YHO A;  4KD7 A;  3SAI A;  4XRB A;  1VDR A;  2QK8 A;  2W3V A;  1RE7 A;  3SA1 A;  4KY8 A;  4ELB A;  3QLR A;  5ECC A;  4KM0 A;  3SRU X;  1CZ3 A;  3EIG A;  3K74 A;  3F0B X;  1RF7 A;  2C2S A;  4X5F A;  4KM2 A;  1CD2 A;  1RA2 A;  3QLW A;  3EEJ A;  2W3W A;  3UM6 A;  3NXV A;  4PSS A;  1IA2 A;  6DFR A;  2HQP A;  2KGK A;  4DPH A;  3NXT A;  1DRF A;  3SR5 X;  1DYH A;  3DAT A;  5DFR A;  1MVS A;  1RX1 A;  4LAE X;  3K47 A;  3IA4 A;  3IRN A;  5EAJ A;  5HF0 X;  3D84 X;  3EEL A;  2C2T A;  3KY8 A;  1M78 A;  4P66 A;  4Q0E A;  1DIU A;  4DPD A;  4QJC A;  3IRM A;  1DHF A;  3JWK A;  5HPB A;  4QLG A;  3FY9 X;  3F0Q X;  1AOE A;  4Q67 A;  1J3K A;  2DRC A;  3F0V X;  1SEJ A;  1RX4 A;  5ECX A;  5JG0 X;  4PSY A;  3SRW X;  1DG7 A;  3JW3 A;  3CSE A;  2O7P A;  5JA3 A;  1KMS A;  1VJ3 A;  3FY8 X;  5HQZ A;  1RX6 A;  3NZC X;  1RA1 A;  4IXE D;  4Q6A A;  4DP3 A;  1OHJ A;  1U70 A;  2D5N A;  4HA7 A;  1KMV A;  1DRH A;  4OSG A;  4KY4 A;  5HSU A;  3NXY A;  2JYB A;  1DR2 A;  3R33 A;  2W9T A;  3DL5 A;  4M6L A;  1JUV A;  3L3R A;  3S9U A;  1BOZ A;  1KLK A;  1RD7 A;  3HBB A;  3NZ9 X;  1S3V A;  2BL9 A;  4HOG A;  3TD8 A;  1DG5 A;  3OAF A;  4KJL A;  3FYV X;  4HOF A;  2W3B A;  1S3Y A;  3NZ6 X;  4P3Q A;  3KJR A;  3QYL A;  3TQ8 A;  3JW5 A;  3RO9 A;  4M7U A;  5HSR A;  3SRQ X;  2B3Z A;  4G3M A;  1RC4 A;  3QFX A;  3QL0 A;  4PTJ A;  4EIL A;  2W9S A;  2D0K A;  5HI6 A;  2HM9 A;  3TQB A;  4LAG X;  1S3U A;  3F8Z A;  4KEB A;  1DAJ A;  3NRR A; 
#chains in the Genus database with same CATH homology
 3E0B A;  1DR5 A;  3RG9 A;  1BZF A;  4QLE A;  3QG2 A;  5CCC A;  4EIZ A;  3EX8 A;  1DDR A;  3GYF A;  4PDJ A;  1DYR A;  1U71 A;  3Q1H A;  5FDA A;  7DFR A;  3OCH A;  1IA1 A;  3GHC A;  4X5I A;  3SA2 A;  4QI9 A;  2FZJ A;  1DR3 A;  3F8Y A;  4FGH A;  3FQC A;  3SRR X;  2P4G A;  3QGT A;  2W9H A;  3N0H A;  3QLZ A;  2HXV A;  4DDR A;  2L28 A;  3FQ0 A;  5HVE A;  3EEM A;  5HVB A;  1RA8 A;  3DFR A;  4X5G A;  1DHI A;  4I13 A;  1RX9 A;  3K2H A;  4XEC X;  4IXG X;  3NXR A;  1DRA A;  4ELE A;  1DYJ A;  1S3W A;  3JVX A;  3NU0 A;  3JTW A;  2AZN A;  3ZPC A;  2G6V A;  4XT8 A;  1RG7 A;  3DAU A;  3IX9 A;  4CD2 A;  2BLC A;  4M6K A;  3S3V A;  1M7A A;  4KJJ A;  4IXF X;  1IA4 A;  1M79 A;  1J3J A;  3FQO A;  3F0S X;  3DGA A;  3ROA A;  3I3R A;  2OBC A;  1AO8 A;  4M7V A;  3JWC A;  1RA3 A;  3F91 A;  1JOL A;  5U27 A;  4KFJ A;  2BLB A;  1DYI A;  3KJS A;  4G95 A;  4Q0D A;  1RB2 A;  3FQF A;  3CLB A;  3JSU A;  3FRD X;  1RA9 A;  2W9G A;  4PTH A;  3FRB X;  3FQV A;  4X5J A;  5HUI A;  4RGC A;  4EIG A;  1PD8 A;  4FHB A;  4QHV A;  1RX7 A;  4H97 A;  4TU5 X;  1RX8 A;  1ZDR A;  2XW7 A;  3EEK A;  5U26 A;  1DHJ A;  3JWF A;  2OIP A;  3GHW A;  3NZB X;  1DR7 A;  1PD9 A;  3FL9 A;  3JWM A;  4XT7 A;  1LY4 A;  1PDB A;  3HJ3 A;  4XE6 X;  4NX6 A;  3KFY A;  3NZA X;  3CD2 A;  4P68 A;  4XT5 A;  3QLS A;  3ZPG A;  1RX3 A;  4OR7 A;  1DLR A;  3SQY X;  3QLY A;  4NX7 A;  4KBN A;  1DDS A;  1LUD A;  3SGY A;  5HT4 A;  1DR6 A;  2INQ A;  4H96 A;  3SRS X;  3IRO A;  5HQY A;  2ANO A;  4HA9 A;  4G8Z X;  4DFR A;  1RH3 A;  1LY3 A;  1DRE A;  3S7A A;  3NZD A;  3I8A X;  4ECK A;  2ZZA A;  4KAK A;  3SH2 A;  1HFP A;  4KJK A;  2W3M A;  3CL9 A;  3UM5 A;  1HFQ A;  4PST A;  1U72 A;  1DRB A;  1MVT A;  3TQA A;  4EJ1 A;  1AI9 A;  1DF7 A;  4LAH X;  3F0X X;  2CIG A;  4QJZ D;  2BLA A;  8DFR A;  3M08 A;  3FRF X;  5HT5 A;  1DR1 A;  3INV A;  1DLS A;  3QLX A;  4X5H A;  5E8Q A;  1RX2 A;  3F0U X;  3IA5 A;  1RX5 A;  1D1G A;  3TQ9 A;  1DR4 A;  1DIS A;  1OHK A;  3DL6 A;  1TDR A;  1E26 A;  1QZF A;  2LF1 A;  4ELH A;  4H98 A;  3NXX A;  3NXO A;  4KL9 A;  4XT4 A;  4H95 A;  4KNE A;  3NTZ A;  3FQZ A;  2ANQ A;  3QL3 A;  4LEK X;  3K45 A;  4M6J A;  3UM8 A;  3FRE X;  3DRC A;  2DHF A;  4I1N A;  4M2X A;  2FZH A;  3FL8 A;  3VCO A;  3GI2 A;  4ELG A;  2CD2 A;  2ITH A;  4KLX A;  5CC9 A;  4P3R A;  3GHV A;  1JOM A;  4GH8 A;  1HFR A;  2FZI A;  1IA3 A;  3LG4 A;  1DG8 A;  4FGG A;  4XT6 A;  4QLF A;  5DXV A;  3FRA X;  3FYW X;  4KYA A;  1J3I A;  4HOE A;  5HF2 X;  3M09 A;  3FS6 A;  3KGY A;  1RB3 A;  2W3A A;  3D80 A;  3DG8 A;  4ELF A;  2GD9 A;  3QYO A;  2H2Q A;  1YHO A;  4KD7 A;  3SAI A;  4XRB A;  1VDR A;  2QK8 A;  2W3V A;  1RE7 A;  3SA1 A;  4KY8 A;  4ELB A;  3QLR A;  5ECC A;  4KM0 A;  3SRU X;  1CZ3 A;  3EIG A;  3K74 A;  3F0B X;  1RF7 A;  2C2S A;  4X5F A;  4KM2 A;  1CD2 A;  1RA2 A;  3QLW A;  3EEJ A;  2W3W A;  3UM6 A;  3NXV A;  4PSS A;  1IA2 A;  6DFR A;  2HQP A;  2KGK A;  4DPH A;  3NXT A;  1DRF A;  3SR5 X;  1DYH A;  3DAT A;  5DFR A;  1MVS A;  1RX1 A;  4LAE X;  3K47 A;  3IA4 A;  3IRN A;  5EAJ A;  5HF0 X;  3D84 X;  3EEL A;  2C2T A;  3KY8 A;  1M78 A;  4P66 A;  4Q0E A;  1DIU A;  4DPD A;  4QJC A;  3IRM A;  1DHF A;  3JWK A;  5HPB A;  4QLG A;  3FY9 X;  3F0Q X;  1AOE A;  4Q67 A;  1J3K A;  2DRC A;  3F0V X;  1SEJ A;  1RX4 A;  5ECX A;  5JG0 X;  4PSY A;  3SRW X;  1DG7 A;  3JW3 A;  3CSE A;  2O7P A;  5JA3 A;  1KMS A;  1VJ3 A;  3FY8 X;  5HQZ A;  1RX6 A;  3NZC X;  1RA1 A;  4IXE D;  4Q6A A;  4DP3 A;  1OHJ A;  1U70 A;  2D5N A;  4HA7 A;  1KMV A;  1DRH A;  4OSG A;  4KY4 A;  5HSU A;  3NXY A;  2JYB A;  1DR2 A;  3R33 A;  2W9T A;  3DL5 A;  4M6L A;  1JUV A;  3L3R A;  3S9U A;  1BOZ A;  1KLK A;  1RD7 A;  3HBB A;  3NZ9 X;  1S3V A;  2BL9 A;  4HOG A;  3TD8 A;  1DG5 A;  3OAF A;  4KJL A;  3FYV X;  4HOF A;  2W3B A;  1S3Y A;  3NZ6 X;  4P3Q A;  3KJR A;  3QYL A;  3TQ8 A;  3JW5 A;  3RO9 A;  4M7U A;  5HSR A;  3SRQ X;  2B3Z A;  4G3M A;  1RC4 A;  3QFX A;  3QL0 A;  4PTJ A;  4EIL A;  2W9S A;  2D0K A;  5HI6 A;  2HM9 A;  3TQB A;  4LAG X;  1S3U A;  3F8Z A;  4KEB A;  1DAJ A;  3NRR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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