1DYHA

Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 44
structure length 159
sequence length 159
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1994-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1dyhA00
3GHVA 2W3VA 4KJJA 1DR5A 4FHBA 7DFRA 3QLZA 1M78A 3KJSA 4KL9A 2W9SA 2L28A 1RF7A 1DR1A 3EEKA 4ELBA 5HI6A 3JWCA 4QLGA 4X5JA 4PSYA 3JWKA 4P68A 3FRBX 2ANQA 3ZPGA 3SAIA 2H2QA 1U71A 3EX8A 3FRFX 4QI9A 4PTHA 5CC9A 1DISA 1KMSA 3DAUA 3GHWA 3F0UX 4DDRA 2DRCA 1RX7A 2GD9A 1DLRA 4M7VA 2DHFA 3FY9X 5JA3A 1DRAA 3IRMA 3FQOA 4HA9A 2CD2A 1DYJA 3F8ZA 2W9GA 3M09A 1DREA 4LAGX 1M7AA 3CD2A 4X5GA 4ELGA 4LEKX 3SRQX 5HPBA 4LAHX 3JWFA 3RG9A 4X5IA 4KY8A 3SQYX 1RA8A 4NX6A 4EILA 4HOGA 3NXXA 3VCOA 3FRAX 1KLKA 4XECX 1CD2A 3JSUA 3K74A 2XW7A 4XT6A 4P3RA 1DRFA 1TDRA 4G8ZX 2W9TA 2W3MA 3EEMA 4KY4A 3FY8X 1DRBA 3K45A 5HT5A 1RX8A 1HFRA 4IXFX 3SRSX 1RX5A 1RA3A 3QG2A 3S9UA 4M6KA 2LF1A 1LY4A 4EJ1A 3QFXA 2BLBA 4KJKA 3F0QX 1DYHA 3QGTA 2ZZAA 4M7UA 3RO9A 3L3RA 4XE6X 1RE7A 3N0HA 4OSGA 3GI2A 1AO8A 2KGKA 1OHKA 4DPDA 4H98A 3JWMA 1DR2A 3CL9A 5HQYA 3SR5X 1RX4A 5HQZA 1DR4A 4KFJA 5HSRA 1S3YA 3NXVA 4G3MA 3S7AA 1VDRA 3FREX 3QLWA 1RX9A 1S3VA 3KGYA 1DR3A 1RX1A 4QHVA 3NZBX 4ECKA 1LUDA 3FYVX 3CSEA 3SGYA 1RH3A 3FQZA 1DF7A 2FZJA 2W3AA 3K2HA 3NXRA 2HM9A 3IX9A 3SRRX 2C2TA 3NZ9X 4KBNA 3QL0A 1RX3A 8DFRA 2D5NA 4KD7A 1PD8A 1DDRA 4CD2A 5FDAA 2AZNA 5ECCA 4P3QA 4DFRA 4PTJA 3QYLA 1ZDRA 3OCHA 3F0VX 3CLBA 3FL9A 5DFRA 3DL6A 5ECXA 1OHJA 4Q0DA 4KJLA 3ZPCA 3NZAX 1PDBA 2W9HA 1RA1A 3NRRA 2B3ZA 1M79A 3SA2A 1AOEA 1S3WA 3HBBA 5HF2X 4ELFA 4X5HA 4IXGX 2OIPA 4EIGA 1DHIA 2ITHA 4FGHA 4PSSA 4ELEA 1RD7A 3D80A 1RG7A 3DL5A 3FYWX 1J3JA 4XT5A 2D0KA 3DATA 2ANOA 3JW3A 1CZ3A 2HQPA 3NXYA 4HOEA 3GHCA 5E8QA 3TQ9A 3OAFA 3ROAA 1DIUA 3K47A 2QK8A 1J3KA 1MVSA 4QJCA 3R33A 2C2SA 4NX7A 3UM5A 3NU0A 3FRDX 3TQBA 6DFRA 3F0SX 3IA5A 3NXTA 1LY3A 5HVBA 3TQ8A 4PDJA 4LAEX 4KAKA 2JYBA 3FQVA 4RGCA 1U72A 1U70A 4G95A 2FZHA 3JTWA 4H97A 1VJ3A 2CIGA 3QLRA 4KM2A 4M2XA 3Q1HA 3QL3A 4KLXA 3I8AX 3JVXA 3KFYA 2HXVA 3EELA 1IA3A 1KMVA 4EIZA 3S3VA 4HOFA 4TU5X 1D1GA 4OR7A 1DYIA 3F0XX 1YHOA 4KNEA 4M6JA 4FGGA 4M6LA 3HJ3A 1E26A 4I13A 1RC4A 3DFRA 3F91A 1RX2A 3I3RA 3INVA 5U27A 3M08A 5EAJA 1RA2A 4XT8A 1BOZA 3GYFA 1QZFA 3QLYA 2BLAA 3FQCA 4XT4A 2INQA 3IRNA 4XRBA 3NZDA 3NXOA 4H96A 3NZ6X 1DYRA 4GH8A 5CCCA 2O7PA 4QLEA 4QLFA 5HSUA 2W3WA 1S3UA 3DRCA 4X5FA 3SH2A 1BZFA 1DDSA 2FZIA 4PSTA 4KEBA 3DGAA 4H95A 3QYOA 3FL8A 3IA4A 4DPHA 4Q67A 2BL9A 1IA2A 1JUVA 3UM8A 1DR7A 5HT4A 3FS6A 5U26A 1MVTA 1DLSA 1RX6A 5HF0X 3LG4A 1DG5A 3D84X 3F0BX 4HA7A 1DHFA 1RB3A 1J3IA 1HFQA 3SRUX 3EIGA 1DHJA 4Q0EA 1SEJA 4IXED 2G6VA 4KM0A 3JW5A 3TQAA 1PD9A 3NTZA 3DG8A 1RA9A 1IA1A 1HFPA 3E0BA 3KY8A 1IA4A 1RB2A 5HUIA 1DG8A 4ELHA 3UM6A 3FQ0A 3EEJA 4DP3A 4I1NA 4XT7A 2W3BA 3SA1A 3QLXA 1DAJA 3QLSA 4QJZD 3NZCX 2BLCA 1AI9A 2OBCA 5HVEA 1JOMA 5JG0X 3KJRA 3IROA 3SRWX 1JOLA 4KYAA 3FQFA 1DR6A 3TD8A 1DRHA 4P66A 5DXVA 3F8YA 2P4GA 1DG7A 4Q6AA
chains in the Genus database with same CATH superfamily
3GHVA 2W3VA 4KJJA 1DR5A 4FHBA 7DFRA 3QLZA 1M78A 3KJSA 4KL9A 2W9SA 2L28A 1RF7A 1DR1A 3EEKA 4ELBA 5HI6A 3JWCA 4QLGA 4X5JA 4PSYA 3JWKA 4P68A 3FRBX 2ANQA 3ZPGA 3SAIA 2H2QA 1U71A 3EX8A 3FRFX 4QI9A 4PTHA 5CC9A 1DISA 1KMSA 3DAUA 3GHWA 3F0UX 4DDRA 2DRCA 1RX7A 2GD9A 1DLRA 4M7VA 2DHFA 3FY9X 5JA3A 1DRAA 3IRMA 3FQOA 4HA9A 2CD2A 1DYJA 3F8ZA 2W9GA 3M09A 1DREA 4LAGX 1M7AA 3CD2A 4X5GA 4ELGA 4LEKX 3SRQX 5HPBA 4LAHX 3JWFA 3RG9A 4X5IA 4KY8A 3SQYX 1RA8A 4NX6A 4EILA 4HOGA 3NXXA 3VCOA 3FRAX 1KLKA 4XECX 1CD2A 3JSUA 3K74A 2XW7A 4XT6A 4P3RA 1DRFA 1TDRA 4G8ZX 2W9TA 2W3MA 3EEMA 4KY4A 3FY8X 1DRBA 3K45A 5HT5A 1RX8A 1HFRA 4IXFX 3SRSX 1RX5A 1RA3A 3QG2A 3S9UA 4M6KA 2LF1A 1LY4A 4EJ1A 3QFXA 2BLBA 4KJKA 3F0QX 1DYHA 3QGTA 2ZZAA 4M7UA 3RO9A 3L3RA 4XE6X 1RE7A 3N0HA 4OSGA 3GI2A 1AO8A 2KGKA 1OHKA 4DPDA 4H98A 3JWMA 1DR2A 3CL9A 5HQYA 3SR5X 1RX4A 5HQZA 1DR4A 4KFJA 5HSRA 1S3YA 3NXVA 4G3MA 3S7AA 1VDRA 3FREX 3QLWA 1RX9A 1S3VA 3KGYA 1DR3A 1RX1A 4QHVA 3NZBX 4ECKA 1LUDA 3FYVX 3CSEA 3SGYA 1RH3A 3FQZA 1DF7A 2FZJA 2W3AA 3K2HA 3NXRA 2HM9A 3IX9A 3SRRX 2C2TA 3NZ9X 4KBNA 3QL0A 1RX3A 8DFRA 2D5NA 4KD7A 1PD8A 1DDRA 4CD2A 5FDAA 2AZNA 5ECCA 4P3QA 4DFRA 4PTJA 3QYLA 1ZDRA 3OCHA 3F0VX 3CLBA 3FL9A 5DFRA 3DL6A 5ECXA 1OHJA 4Q0DA 4KJLA 3ZPCA 3NZAX 1PDBA 2W9HA 1RA1A 3NRRA 2B3ZA 1M79A 3SA2A 1AOEA 1S3WA 3HBBA 5HF2X 4ELFA 4X5HA 4IXGX 2OIPA 4EIGA 1DHIA 2ITHA 4FGHA 4PSSA 4ELEA 1RD7A 3D80A 1RG7A 3DL5A 3FYWX 1J3JA 4XT5A 2D0KA 3DATA 2ANOA 3JW3A 1CZ3A 2HQPA 3NXYA 4HOEA 3GHCA 5E8QA 3TQ9A 3OAFA 3ROAA 1DIUA 3K47A 2QK8A 1J3KA 1MVSA 4QJCA 3R33A 2C2SA 4NX7A 3UM5A 3NU0A 3FRDX 3TQBA 6DFRA 3F0SX 3IA5A 3NXTA 1LY3A 5HVBA 3TQ8A 4PDJA 4LAEX 4KAKA 2JYBA 3FQVA 4RGCA 1U72A 1U70A 4G95A 2FZHA 3JTWA 4H97A 1VJ3A 2CIGA 3QLRA 4KM2A 4M2XA 3Q1HA 3QL3A 4KLXA 3I8AX 3JVXA 3KFYA 2HXVA 3EELA 1IA3A 1KMVA 4EIZA 3S3VA 4HOFA 4TU5X 1D1GA 4OR7A 1DYIA 3F0XX 1YHOA 4KNEA 4M6JA 4FGGA 4M6LA 3HJ3A 1E26A 4I13A 1RC4A 3DFRA 3F91A 1RX2A 3I3RA 3INVA 5U27A 3M08A 5EAJA 1RA2A 4XT8A 1BOZA 3GYFA 1QZFA 3QLYA 2BLAA 3FQCA 4XT4A 2INQA 3IRNA 4XRBA 3NZDA 3NXOA 4H96A 3NZ6X 1DYRA 4GH8A 5CCCA 2O7PA 4QLEA 4QLFA 5HSUA 2W3WA 1S3UA 3DRCA 4X5FA 3SH2A 1BZFA 1DDSA 2FZIA 4PSTA 4KEBA 3DGAA 4H95A 3QYOA 3FL8A 3IA4A 4DPHA 4Q67A 2BL9A 1IA2A 1JUVA 3UM8A 1DR7A 5HT4A 3FS6A 5U26A 1MVTA 1DLSA 1RX6A 5HF0X 3LG4A 1DG5A 3D84X 3F0BX 4HA7A 1DHFA 1RB3A 1J3IA 1HFQA 3SRUX 3EIGA 1DHJA 4Q0EA 1SEJA 4IXED 2G6VA 4KM0A 3JW5A 3TQAA 1PD9A 3NTZA 3DG8A 1RA9A 1IA1A 1HFPA 3E0BA 3KY8A 1IA4A 1RB2A 5HUIA 1DG8A 4ELHA 3UM6A 3FQ0A 3EEJA 4DP3A 4I1NA 4XT7A 2W3BA 3SA1A 3QLXA 1DAJA 3QLSA 4QJZD 3NZCX 2BLCA 1AI9A 2OBCA 5HVEA 1JOMA 5JG0X 3KJRA 3IROA 3SRWX 1JOLA 4KYAA 3FQFA 1DR6A 3TD8A 1DRHA 4P66A 5DXVA 3F8YA 2P4GA 1DG7A 4Q6AA
chains in the Genus database with same CATH topology
3GHVA 2W3VA 4KJJA 1DR5A 4FHBA 7DFRA 3QLZA 1M78A 3KJSA 4KL9A 2W9SA 2L28A 1RF7A 1DR1A 3EEKA 4ELBA 5HI6A 3JWCA 4QLGA 4X5JA 4PSYA 3JWKA 4P68A 3FRBX 2ANQA 3ZPGA 3SAIA 2H2QA 1U71A 3EX8A 3FRFX 4QI9A 4PTHA 5CC9A 1DISA 1KMSA 3DAUA 3GHWA 3F0UX 4DDRA 2DRCA 1RX7A 2GD9A 1DLRA 4M7VA 2DHFA 3FY9X 5JA3A 1DRAA 3IRMA 3FQOA 4HA9A 2CD2A 1DYJA 3F8ZA 2W9GA 3M09A 1DREA 4LAGX 1M7AA 3CD2A 4X5GA 4ELGA 4LEKX 3SRQX 5HPBA 4LAHX 3JWFA 3RG9A 4X5IA 4KY8A 3SQYX 1RA8A 4NX6A 4EILA 4HOGA 3NXXA 3VCOA 3FRAX 1KLKA 4XECX 1CD2A 3JSUA 3K74A 2XW7A 4XT6A 4P3RA 1DRFA 1TDRA 4G8ZX 2W9TA 2W3MA 3EEMA 4KY4A 3FY8X 1DRBA 3K45A 5HT5A 1RX8A 1HFRA 4IXFX 3SRSX 1RX5A 1RA3A 3QG2A 3S9UA 4M6KA 2LF1A 1LY4A 4EJ1A 3QFXA 2BLBA 4KJKA 3F0QX 1DYHA 3QGTA 2ZZAA 4M7UA 3RO9A 3L3RA 4XE6X 1RE7A 3N0HA 4OSGA 3GI2A 1AO8A 2KGKA 1OHKA 4DPDA 4H98A 3JWMA 1DR2A 3CL9A 5HQYA 3SR5X 1RX4A 5HQZA 1DR4A 4KFJA 5HSRA 1S3YA 3NXVA 4G3MA 3S7AA 1VDRA 3FREX 3QLWA 1RX9A 1S3VA 3KGYA 1DR3A 1RX1A 4QHVA 3NZBX 4ECKA 1LUDA 3FYVX 3CSEA 3SGYA 1RH3A 3FQZA 1DF7A 2FZJA 2W3AA 3K2HA 3NXRA 2HM9A 3IX9A 3SRRX 2C2TA 3NZ9X 4KBNA 3QL0A 1RX3A 8DFRA 2D5NA 4KD7A 1PD8A 1DDRA 4CD2A 5FDAA 2AZNA 5ECCA 4P3QA 4DFRA 4PTJA 3QYLA 1ZDRA 3OCHA 3F0VX 3CLBA 3FL9A 5DFRA 3DL6A 5ECXA 1OHJA 4Q0DA 4KJLA 3ZPCA 3NZAX 1PDBA 2W9HA 1RA1A 3NRRA 2B3ZA 1M79A 3SA2A 1AOEA 1S3WA 3HBBA 5HF2X 4ELFA 4X5HA 4IXGX 2OIPA 4EIGA 1DHIA 2ITHA 4FGHA 4PSSA 4ELEA 1RD7A 3D80A 1RG7A 3DL5A 3FYWX 1J3JA 4XT5A 2D0KA 3DATA 2ANOA 3JW3A 1CZ3A 2HQPA 3NXYA 4HOEA 3GHCA 5E8QA 3TQ9A 3OAFA 3ROAA 1DIUA 3K47A 2QK8A 1J3KA 1MVSA 4QJCA 3R33A 2C2SA 4NX7A 3UM5A 3NU0A 3FRDX 3TQBA 6DFRA 3F0SX 3IA5A 3NXTA 1LY3A 5HVBA 3TQ8A 4PDJA 4LAEX 4KAKA 2JYBA 3FQVA 4RGCA 1U72A 1U70A 4G95A 2FZHA 3JTWA 4H97A 1VJ3A 2CIGA 3QLRA 4KM2A 4M2XA 3Q1HA 3QL3A 4KLXA 3I8AX 3JVXA 3KFYA 2HXVA 3EELA 1IA3A 1KMVA 4EIZA 3S3VA 4HOFA 4TU5X 1D1GA 4OR7A 1DYIA 3F0XX 1YHOA 4KNEA 4M6JA 4FGGA 4M6LA 3HJ3A 1E26A 4I13A 1RC4A 3DFRA 3F91A 1RX2A 3I3RA 3INVA 5U27A 3M08A 5EAJA 1RA2A 4XT8A 1BOZA 3GYFA 1QZFA 3QLYA 2BLAA 3FQCA 4XT4A 2INQA 3IRNA 4XRBA 3NZDA 3NXOA 4H96A 3NZ6X 1DYRA 4GH8A 5CCCA 2O7PA 4QLEA 4QLFA 5HSUA 2W3WA 1S3UA 3DRCA 4X5FA 3SH2A 1BZFA 1DDSA 2FZIA 4PSTA 4KEBA 3DGAA 4H95A 3QYOA 3FL8A 3IA4A 4DPHA 4Q67A 2BL9A 1IA2A 1JUVA 3UM8A 1DR7A 5HT4A 3FS6A 5U26A 1MVTA 1DLSA 1RX6A 5HF0X 3LG4A 1DG5A 3D84X 3F0BX 4HA7A 1DHFA 1RB3A 1J3IA 1HFQA 3SRUX 3EIGA 1DHJA 4Q0EA 1SEJA 4IXED 2G6VA 4KM0A 3JW5A 3TQAA 1PD9A 3NTZA 3DG8A 1RA9A 1IA1A 1HFPA 3E0BA 3KY8A 1IA4A 1RB2A 5HUIA 1DG8A 4ELHA 3UM6A 3FQ0A 3EEJA 4DP3A 4I1NA 4XT7A 2W3BA 3SA1A 3QLXA 1DAJA 3QLSA 4QJZD 3NZCX 2BLCA 1AI9A 2OBCA 5HVEA 1JOMA 5JG0X 3KJRA 3IROA 3SRWX 1JOLA 4KYAA 3FQFA 1DR6A 3TD8A 1DRHA 4P66A 5DXVA 3F8YA 2P4GA 1DG7A 4Q6AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GHV A;  2W3V A;  4KJJ A;  1DR5 A;  4FHB A;  7DFR A;  3QLZ A;  1M78 A;  3KJS A;  4KL9 A;  2W9S A;  2L28 A;  1RF7 A;  1DR1 A;  3EEK A;  4ELB A;  5HI6 A;  3JWC A;  4QLG A;  4X5J A;  4PSY A;  3JWK A;  4P68 A;  3FRB X;  2ANQ A;  3ZPG A;  3SAI A;  2H2Q A;  1U71 A;  3EX8 A;  3FRF X;  4QI9 A;  4PTH A;  5CC9 A;  1DIS A;  1KMS A;  3DAU A;  3GHW A;  3F0U X;  4DDR A;  2DRC A;  1RX7 A;  2GD9 A;  1DLR A;  4M7V A;  2DHF A;  3FY9 X;  5JA3 A;  1DRA A;  3IRM A;  3FQO A;  4HA9 A;  2CD2 A;  1DYJ A;  3F8Z A;  2W9G A;  3M09 A;  1DRE A;  4LAG X;  1M7A A;  3CD2 A;  4X5G A;  4ELG A;  4LEK X;  3SRQ X;  5HPB A;  4LAH X;  3JWF A;  3RG9 A;  4X5I A;  4KY8 A;  3SQY X;  1RA8 A;  4NX6 A;  4EIL A;  4HOG A;  3NXX A;  3VCO A;  3FRA X;  1KLK A;  4XEC X;  1CD2 A;  3JSU A;  3K74 A;  2XW7 A;  4XT6 A;  4P3R A;  1DRF A;  1TDR A;  4G8Z X;  2W9T A;  2W3M A;  3EEM A;  4KY4 A;  3FY8 X;  1DRB A;  3K45 A;  5HT5 A;  1RX8 A;  1HFR A;  4IXF X;  3SRS X;  1RX5 A;  1RA3 A;  3QG2 A;  3S9U A;  4M6K A;  2LF1 A;  1LY4 A;  4EJ1 A;  3QFX A;  2BLB A;  4KJK A;  3F0Q X;  1DYH A;  3QGT A;  2ZZA A;  4M7U A;  3RO9 A;  3L3R A;  4XE6 X;  1RE7 A;  3N0H A;  4OSG A;  3GI2 A;  1AO8 A;  2KGK A;  1OHK A;  4DPD A;  4H98 A;  3JWM A;  1DR2 A;  3CL9 A;  5HQY A;  3SR5 X;  1RX4 A;  5HQZ A;  1DR4 A;  4KFJ A;  5HSR A;  1S3Y A;  3NXV A;  4G3M A;  3S7A A;  1VDR A;  3FRE X;  3QLW A;  1RX9 A;  1S3V A;  3KGY A;  1DR3 A;  1RX1 A;  4QHV A;  3NZB X;  4ECK A;  1LUD A;  3FYV X;  3CSE A;  3SGY A;  1RH3 A;  3FQZ A;  1DF7 A;  2FZJ A;  2W3A A;  3K2H A;  3NXR A;  2HM9 A;  3IX9 A;  3SRR X;  2C2T A;  3NZ9 X;  4KBN A;  3QL0 A;  1RX3 A;  8DFR A;  2D5N A;  4KD7 A;  1PD8 A;  1DDR A;  4CD2 A;  5FDA A;  2AZN A;  5ECC A;  4P3Q A;  4DFR A;  4PTJ A;  3QYL A;  1ZDR A;  3OCH A;  3F0V X;  3CLB A;  3FL9 A;  5DFR A;  3DL6 A;  5ECX A;  1OHJ A;  4Q0D A;  4KJL A;  3ZPC A;  3NZA X;  1PDB A;  2W9H A;  1RA1 A;  3NRR A;  2B3Z A;  1M79 A;  3SA2 A;  1AOE A;  1S3W A;  3HBB A;  5HF2 X;  4ELF A;  4X5H A;  4IXG X;  2OIP A;  4EIG A;  1DHI A;  2ITH A;  4FGH A;  4PSS A;  4ELE A;  1RD7 A;  3D80 A;  1RG7 A;  3DL5 A;  3FYW X;  1J3J A;  4XT5 A;  2D0K A;  3DAT A;  2ANO A;  3JW3 A;  1CZ3 A;  2HQP A;  3NXY A;  4HOE A;  3GHC A;  5E8Q A;  3TQ9 A;  3OAF A;  3ROA A;  1DIU A;  3K47 A;  2QK8 A;  1J3K A;  1MVS A;  4QJC A;  3R33 A;  2C2S A;  4NX7 A;  3UM5 A;  3NU0 A;  3FRD X;  3TQB A;  6DFR A;  3F0S X;  3IA5 A;  3NXT A;  1LY3 A;  5HVB A;  3TQ8 A;  4PDJ A;  4LAE X;  4KAK A;  2JYB A;  3FQV A;  4RGC A;  1U72 A;  1U70 A;  4G95 A;  2FZH A;  3JTW A;  4H97 A;  1VJ3 A;  2CIG A;  3QLR A;  4KM2 A;  4M2X A;  3Q1H A;  3QL3 A;  4KLX A;  3I8A X;  3JVX A;  3KFY A;  2HXV A;  3EEL A;  1IA3 A;  1KMV A;  4EIZ A;  3S3V A;  4HOF A;  4TU5 X;  1D1G A;  4OR7 A;  1DYI A;  3F0X X;  1YHO A;  4KNE A;  4M6J A;  4FGG A;  4M6L A;  3HJ3 A;  1E26 A;  4I13 A;  1RC4 A;  3DFR A;  3F91 A;  1RX2 A;  3I3R A;  3INV A;  5U27 A;  3M08 A;  5EAJ A;  1RA2 A;  4XT8 A;  1BOZ A;  3GYF A;  1QZF A;  3QLY A;  2BLA A;  3FQC A;  4XT4 A;  2INQ A;  3IRN A;  4XRB A;  3NZD A;  3NXO A;  4H96 A;  3NZ6 X;  1DYR A;  4GH8 A;  5CCC A;  2O7P A;  4QLE A;  4QLF A;  5HSU A;  2W3W A;  1S3U A;  3DRC A;  4X5F A;  3SH2 A;  1BZF A;  1DDS A;  2FZI A;  4PST A;  4KEB A;  3DGA A;  4H95 A;  3QYO A;  3FL8 A;  3IA4 A;  4DPH A;  4Q67 A;  2BL9 A;  1IA2 A;  1JUV A;  3UM8 A;  1DR7 A;  5HT4 A;  3FS6 A;  5U26 A;  1MVT A;  1DLS A;  1RX6 A;  5HF0 X;  3LG4 A;  1DG5 A;  3D84 X;  3F0B X;  4HA7 A;  1DHF A;  1RB3 A;  1J3I A;  1HFQ A;  3SRU X;  3EIG A;  1DHJ A;  4Q0E A;  1SEJ A;  4IXE D;  2G6V A;  4KM0 A;  3JW5 A;  3TQA A;  1PD9 A;  3NTZ A;  3DG8 A;  1RA9 A;  1IA1 A;  1HFP A;  3E0B A;  3KY8 A;  1IA4 A;  1RB2 A;  5HUI A;  1DG8 A;  4ELH A;  3UM6 A;  3FQ0 A;  3EEJ A;  4DP3 A;  4I1N A;  4XT7 A;  2W3B A;  3SA1 A;  3QLX A;  1DAJ A;  3QLS A;  4QJZ D;  3NZC X;  2BLC A;  1AI9 A;  2OBC A;  5HVE A;  1JOM A;  5JG0 X;  3KJR A;  3IRO A;  3SRW X;  1JOL A;  4KYA A;  3FQF A;  1DR6 A;  3TD8 A;  1DRH A;  4P66 A;  5DXV A;  3F8Y A;  2P4G A;  1DG7 A;  4Q6A A; 
#chains in the Genus database with same CATH topology
 3GHV A;  2W3V A;  4KJJ A;  1DR5 A;  4FHB A;  7DFR A;  3QLZ A;  1M78 A;  3KJS A;  4KL9 A;  2W9S A;  2L28 A;  1RF7 A;  1DR1 A;  3EEK A;  4ELB A;  5HI6 A;  3JWC A;  4QLG A;  4X5J A;  4PSY A;  3JWK A;  4P68 A;  3FRB X;  2ANQ A;  3ZPG A;  3SAI A;  2H2Q A;  1U71 A;  3EX8 A;  3FRF X;  4QI9 A;  4PTH A;  5CC9 A;  1DIS A;  1KMS A;  3DAU A;  3GHW A;  3F0U X;  4DDR A;  2DRC A;  1RX7 A;  2GD9 A;  1DLR A;  4M7V A;  2DHF A;  3FY9 X;  5JA3 A;  1DRA A;  3IRM A;  3FQO A;  4HA9 A;  2CD2 A;  1DYJ A;  3F8Z A;  2W9G A;  3M09 A;  1DRE A;  4LAG X;  1M7A A;  3CD2 A;  4X5G A;  4ELG A;  4LEK X;  3SRQ X;  5HPB A;  4LAH X;  3JWF A;  3RG9 A;  4X5I A;  4KY8 A;  3SQY X;  1RA8 A;  4NX6 A;  4EIL A;  4HOG A;  3NXX A;  3VCO A;  3FRA X;  1KLK A;  4XEC X;  1CD2 A;  3JSU A;  3K74 A;  2XW7 A;  4XT6 A;  4P3R A;  1DRF A;  1TDR A;  4G8Z X;  2W9T A;  2W3M A;  3EEM A;  4KY4 A;  3FY8 X;  1DRB A;  3K45 A;  5HT5 A;  1RX8 A;  1HFR A;  4IXF X;  3SRS X;  1RX5 A;  1RA3 A;  3QG2 A;  3S9U A;  4M6K A;  2LF1 A;  1LY4 A;  4EJ1 A;  3QFX A;  2BLB A;  4KJK A;  3F0Q X;  1DYH A;  3QGT A;  2ZZA A;  4M7U A;  3RO9 A;  3L3R A;  4XE6 X;  1RE7 A;  3N0H A;  4OSG A;  3GI2 A;  1AO8 A;  2KGK A;  1OHK A;  4DPD A;  4H98 A;  3JWM A;  1DR2 A;  3CL9 A;  5HQY A;  3SR5 X;  1RX4 A;  5HQZ A;  1DR4 A;  4KFJ A;  5HSR A;  1S3Y A;  3NXV A;  4G3M A;  3S7A A;  1VDR A;  3FRE X;  3QLW A;  1RX9 A;  1S3V A;  3KGY A;  1DR3 A;  1RX1 A;  4QHV A;  3NZB X;  4ECK A;  1LUD A;  3FYV X;  3CSE A;  3SGY A;  1RH3 A;  3FQZ A;  1DF7 A;  2FZJ A;  2W3A A;  3K2H A;  3NXR A;  2HM9 A;  3IX9 A;  3SRR X;  2C2T A;  3NZ9 X;  4KBN A;  3QL0 A;  1RX3 A;  8DFR A;  2D5N A;  4KD7 A;  1PD8 A;  1DDR A;  4CD2 A;  5FDA A;  2AZN A;  5ECC A;  4P3Q A;  4DFR A;  4PTJ A;  3QYL A;  1ZDR A;  3OCH A;  3F0V X;  3CLB A;  3FL9 A;  5DFR A;  3DL6 A;  5ECX A;  1OHJ A;  4Q0D A;  4KJL A;  3ZPC A;  3NZA X;  1PDB A;  2W9H A;  1RA1 A;  3NRR A;  2B3Z A;  1M79 A;  3SA2 A;  1AOE A;  1S3W A;  3HBB A;  5HF2 X;  4ELF A;  4X5H A;  4IXG X;  2OIP A;  4EIG A;  1DHI A;  2ITH A;  4FGH A;  4PSS A;  4ELE A;  1RD7 A;  3D80 A;  1RG7 A;  3DL5 A;  3FYW X;  1J3J A;  4XT5 A;  2D0K A;  3DAT A;  2ANO A;  3JW3 A;  1CZ3 A;  2HQP A;  3NXY A;  4HOE A;  3GHC A;  5E8Q A;  3TQ9 A;  3OAF A;  3ROA A;  1DIU A;  3K47 A;  2QK8 A;  1J3K A;  1MVS A;  4QJC A;  3R33 A;  2C2S A;  4NX7 A;  3UM5 A;  3NU0 A;  3FRD X;  3TQB A;  6DFR A;  3F0S X;  3IA5 A;  3NXT A;  1LY3 A;  5HVB A;  3TQ8 A;  4PDJ A;  4LAE X;  4KAK A;  2JYB A;  3FQV A;  4RGC A;  1U72 A;  1U70 A;  4G95 A;  2FZH A;  3JTW A;  4H97 A;  1VJ3 A;  2CIG A;  3QLR A;  4KM2 A;  4M2X A;  3Q1H A;  3QL3 A;  4KLX A;  3I8A X;  3JVX A;  3KFY A;  2HXV A;  3EEL A;  1IA3 A;  1KMV A;  4EIZ A;  3S3V A;  4HOF A;  4TU5 X;  1D1G A;  4OR7 A;  1DYI A;  3F0X X;  1YHO A;  4KNE A;  4M6J A;  4FGG A;  4M6L A;  3HJ3 A;  1E26 A;  4I13 A;  1RC4 A;  3DFR A;  3F91 A;  1RX2 A;  3I3R A;  3INV A;  5U27 A;  3M08 A;  5EAJ A;  1RA2 A;  4XT8 A;  1BOZ A;  3GYF A;  1QZF A;  3QLY A;  2BLA A;  3FQC A;  4XT4 A;  2INQ A;  3IRN A;  4XRB A;  3NZD A;  3NXO A;  4H96 A;  3NZ6 X;  1DYR A;  4GH8 A;  5CCC A;  2O7P A;  4QLE A;  4QLF A;  5HSU A;  2W3W A;  1S3U A;  3DRC A;  4X5F A;  3SH2 A;  1BZF A;  1DDS A;  2FZI A;  4PST A;  4KEB A;  3DGA A;  4H95 A;  3QYO A;  3FL8 A;  3IA4 A;  4DPH A;  4Q67 A;  2BL9 A;  1IA2 A;  1JUV A;  3UM8 A;  1DR7 A;  5HT4 A;  3FS6 A;  5U26 A;  1MVT A;  1DLS A;  1RX6 A;  5HF0 X;  3LG4 A;  1DG5 A;  3D84 X;  3F0B X;  4HA7 A;  1DHF A;  1RB3 A;  1J3I A;  1HFQ A;  3SRU X;  3EIG A;  1DHJ A;  4Q0E A;  1SEJ A;  4IXE D;  2G6V A;  4KM0 A;  3JW5 A;  3TQA A;  1PD9 A;  3NTZ A;  3DG8 A;  1RA9 A;  1IA1 A;  1HFP A;  3E0B A;  3KY8 A;  1IA4 A;  1RB2 A;  5HUI A;  1DG8 A;  4ELH A;  3UM6 A;  3FQ0 A;  3EEJ A;  4DP3 A;  4I1N A;  4XT7 A;  2W3B A;  3SA1 A;  3QLX A;  1DAJ A;  3QLS A;  4QJZ D;  3NZC X;  2BLC A;  1AI9 A;  2OBC A;  5HVE A;  1JOM A;  5JG0 X;  3KJR A;  3IRO A;  3SRW X;  1JOL A;  4KYA A;  3FQF A;  1DR6 A;  3TD8 A;  1DRH A;  4P66 A;  5DXV A;  3F8Y A;  2P4G A;  1DG7 A;  4Q6A A; 
#chains in the Genus database with same CATH homology
 3GHV A;  2W3V A;  4KJJ A;  1DR5 A;  4FHB A;  7DFR A;  3QLZ A;  1M78 A;  3KJS A;  4KL9 A;  2W9S A;  2L28 A;  1RF7 A;  1DR1 A;  3EEK A;  4ELB A;  5HI6 A;  3JWC A;  4QLG A;  4X5J A;  4PSY A;  3JWK A;  4P68 A;  3FRB X;  2ANQ A;  3ZPG A;  3SAI A;  2H2Q A;  1U71 A;  3EX8 A;  3FRF X;  4QI9 A;  4PTH A;  5CC9 A;  1DIS A;  1KMS A;  3DAU A;  3GHW A;  3F0U X;  4DDR A;  2DRC A;  1RX7 A;  2GD9 A;  1DLR A;  4M7V A;  2DHF A;  3FY9 X;  5JA3 A;  1DRA A;  3IRM A;  3FQO A;  4HA9 A;  2CD2 A;  1DYJ A;  3F8Z A;  2W9G A;  3M09 A;  1DRE A;  4LAG X;  1M7A A;  3CD2 A;  4X5G A;  4ELG A;  4LEK X;  3SRQ X;  5HPB A;  4LAH X;  3JWF A;  3RG9 A;  4X5I A;  4KY8 A;  3SQY X;  1RA8 A;  4NX6 A;  4EIL A;  4HOG A;  3NXX A;  3VCO A;  3FRA X;  1KLK A;  4XEC X;  1CD2 A;  3JSU A;  3K74 A;  2XW7 A;  4XT6 A;  4P3R A;  1DRF A;  1TDR A;  4G8Z X;  2W9T A;  2W3M A;  3EEM A;  4KY4 A;  3FY8 X;  1DRB A;  3K45 A;  5HT5 A;  1RX8 A;  1HFR A;  4IXF X;  3SRS X;  1RX5 A;  1RA3 A;  3QG2 A;  3S9U A;  4M6K A;  2LF1 A;  1LY4 A;  4EJ1 A;  3QFX A;  2BLB A;  4KJK A;  3F0Q X;  1DYH A;  3QGT A;  2ZZA A;  4M7U A;  3RO9 A;  3L3R A;  4XE6 X;  1RE7 A;  3N0H A;  4OSG A;  3GI2 A;  1AO8 A;  2KGK A;  1OHK A;  4DPD A;  4H98 A;  3JWM A;  1DR2 A;  3CL9 A;  5HQY A;  3SR5 X;  1RX4 A;  5HQZ A;  1DR4 A;  4KFJ A;  5HSR A;  1S3Y A;  3NXV A;  4G3M A;  3S7A A;  1VDR A;  3FRE X;  3QLW A;  1RX9 A;  1S3V A;  3KGY A;  1DR3 A;  1RX1 A;  4QHV A;  3NZB X;  4ECK A;  1LUD A;  3FYV X;  3CSE A;  3SGY A;  1RH3 A;  3FQZ A;  1DF7 A;  2FZJ A;  2W3A A;  3K2H A;  3NXR A;  2HM9 A;  3IX9 A;  3SRR X;  2C2T A;  3NZ9 X;  4KBN A;  3QL0 A;  1RX3 A;  8DFR A;  2D5N A;  4KD7 A;  1PD8 A;  1DDR A;  4CD2 A;  5FDA A;  2AZN A;  5ECC A;  4P3Q A;  4DFR A;  4PTJ A;  3QYL A;  1ZDR A;  3OCH A;  3F0V X;  3CLB A;  3FL9 A;  5DFR A;  3DL6 A;  5ECX A;  1OHJ A;  4Q0D A;  4KJL A;  3ZPC A;  3NZA X;  1PDB A;  2W9H A;  1RA1 A;  3NRR A;  2B3Z A;  1M79 A;  3SA2 A;  1AOE A;  1S3W A;  3HBB A;  5HF2 X;  4ELF A;  4X5H A;  4IXG X;  2OIP A;  4EIG A;  1DHI A;  2ITH A;  4FGH A;  4PSS A;  4ELE A;  1RD7 A;  3D80 A;  1RG7 A;  3DL5 A;  3FYW X;  1J3J A;  4XT5 A;  2D0K A;  3DAT A;  2ANO A;  3JW3 A;  1CZ3 A;  2HQP A;  3NXY A;  4HOE A;  3GHC A;  5E8Q A;  3TQ9 A;  3OAF A;  3ROA A;  1DIU A;  3K47 A;  2QK8 A;  1J3K A;  1MVS A;  4QJC A;  3R33 A;  2C2S A;  4NX7 A;  3UM5 A;  3NU0 A;  3FRD X;  3TQB A;  6DFR A;  3F0S X;  3IA5 A;  3NXT A;  1LY3 A;  5HVB A;  3TQ8 A;  4PDJ A;  4LAE X;  4KAK A;  2JYB A;  3FQV A;  4RGC A;  1U72 A;  1U70 A;  4G95 A;  2FZH A;  3JTW A;  4H97 A;  1VJ3 A;  2CIG A;  3QLR A;  4KM2 A;  4M2X A;  3Q1H A;  3QL3 A;  4KLX A;  3I8A X;  3JVX A;  3KFY A;  2HXV A;  3EEL A;  1IA3 A;  1KMV A;  4EIZ A;  3S3V A;  4HOF A;  4TU5 X;  1D1G A;  4OR7 A;  1DYI A;  3F0X X;  1YHO A;  4KNE A;  4M6J A;  4FGG A;  4M6L A;  3HJ3 A;  1E26 A;  4I13 A;  1RC4 A;  3DFR A;  3F91 A;  1RX2 A;  3I3R A;  3INV A;  5U27 A;  3M08 A;  5EAJ A;  1RA2 A;  4XT8 A;  1BOZ A;  3GYF A;  1QZF A;  3QLY A;  2BLA A;  3FQC A;  4XT4 A;  2INQ A;  3IRN A;  4XRB A;  3NZD A;  3NXO A;  4H96 A;  3NZ6 X;  1DYR A;  4GH8 A;  5CCC A;  2O7P A;  4QLE A;  4QLF A;  5HSU A;  2W3W A;  1S3U A;  3DRC A;  4X5F A;  3SH2 A;  1BZF A;  1DDS A;  2FZI A;  4PST A;  4KEB A;  3DGA A;  4H95 A;  3QYO A;  3FL8 A;  3IA4 A;  4DPH A;  4Q67 A;  2BL9 A;  1IA2 A;  1JUV A;  3UM8 A;  1DR7 A;  5HT4 A;  3FS6 A;  5U26 A;  1MVT A;  1DLS A;  1RX6 A;  5HF0 X;  3LG4 A;  1DG5 A;  3D84 X;  3F0B X;  4HA7 A;  1DHF A;  1RB3 A;  1J3I A;  1HFQ A;  3SRU X;  3EIG A;  1DHJ A;  4Q0E A;  1SEJ A;  4IXE D;  2G6V A;  4KM0 A;  3JW5 A;  3TQA A;  1PD9 A;  3NTZ A;  3DG8 A;  1RA9 A;  1IA1 A;  1HFP A;  3E0B A;  3KY8 A;  1IA4 A;  1RB2 A;  5HUI A;  1DG8 A;  4ELH A;  3UM6 A;  3FQ0 A;  3EEJ A;  4DP3 A;  4I1N A;  4XT7 A;  2W3B A;  3SA1 A;  3QLX A;  1DAJ A;  3QLS A;  4QJZ D;  3NZC X;  2BLC A;  1AI9 A;  2OBC A;  5HVE A;  1JOM A;  5JG0 X;  3KJR A;  3IRO A;  3SRW X;  1JOL A;  4KYA A;  3FQF A;  1DR6 A;  3TD8 A;  1DRH A;  4P66 A;  5DXV A;  3F8Y A;  2P4G A;  1DG7 A;  4Q6A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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