1DYIA

Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 44
structure length 159
sequence length 159
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1994-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1dyiA00
3SRSX 3L3RA 4H96A 4M2XA 1IA4A 7DFRA 4Q0EA 5HQYA 3DAUA 3GHVA 1S3VA 1RX6A 3K2HA 3SR5X 4KY8A 4M6JA 2W3AA 1DG7A 1M7AA 4PSSA 4G95A 1DLSA 3FRFX 1OHKA 5HSUA 3OCHA 4M7UA 4KFJA 2HQPA 1RD7A 3SH2A 4LAEX 4ELBA 1RA3A 4RGCA 4H95A 2W3VA 3EEKA 3NXTA 1KLKA 3GHWA 1JOLA 1M78A 5ECCA 2ANQA 2XW7A 1D1GA 3M08A 1JUVA 4ECKA 5U27A 1CD2A 3TQ8A 1DR5A 1SEJA 3GI2A 1DR4A 3SRRX 3JWCA 3QLYA 3JSUA 4PTHA 3EIGA 1RX5A 4M7VA 4XT4A 3NXYA 1IA3A 3DG8A 3QYLA 2W3WA 5HI6A 2W9GA 3QLXA 3K47A 4KBNA 3TQBA 5HUIA 4PDJA 3ZPGA 1DIUA 4KJKA 3CSEA 1DYRA 2C2TA 3FQFA 5HT5A 1QZFA 4Q0DA 3EX8A 3EELA 3IA5A 4DPHA 3F0VX 1S3WA 4FGHA 3CLBA 4Q67A 3UM5A 3NZCX 1J3KA 1LUDA 3GHCA 3JWFA 3SAIA 4KJLA 1VJ3A 1RX4A 3D80A 4QLGA 3DGAA 4X5IA 3DFRA 1HFRA 4X5HA 4KAKA 3UM8A 1RC4A 1U70A 2HM9A 5HSRA 1PDBA 3DRCA 3JW3A 3QLSA 4DDRA 3FQZA 5DXVA 4I1NA 4G3MA 1J3JA 4P66A 5JG0X 3QLRA 1RG7A 3ROAA 2W9HA 5ECXA 4IXED 2CD2A 1RA8A 1IA1A 1U71A 3I3RA 2ANOA 3QG2A 4P3RA 3QLZA 3VCOA 3NTZA 3INVA 3SA2A 4XT6A 3EEMA 3F0SX 3SRWX 3NZ6X 1DYJA 1DR1A 3JVXA 2AZNA 3FQOA 4KEBA 2ITHA 3Q1HA 1CZ3A 2W3MA 4ELEA 4GH8A 3EEJA 3FYVX 4M6LA 5HF0X 2CIGA 3JWKA 5U26A 1DF7A 4DPDA 4G8ZX 3F0UX 1KMVA 5HT4A 3IRMA 1BZFA 5DFRA 1PD8A 4H97A 1RB3A 4P3QA 1DISA 4HOFA 2C2SA 1DRFA 1HFQA 4QJZD 1AOEA 3F0XX 3FQ0A 3QYOA 3ZPCA 3D84X 3FS6A 3NZDA 3RO9A 3F0BX 4EJ1A 3JTWA 5HVBA 2GD9A 2FZJA 3I8AX 3FL8A 1OHJA 4XT5A 3M09A 4OR7A 1RX3A 5HF2X 1DREA 3F8ZA 1DDRA 1YHOA 4LEKX 3E0BA 2BLAA 3IA4A 3NZBX 4CD2A 3R33A 3OAFA 4PSTA 1RX7A 4M6KA 5HQZA 3FY8X 5CCCA 2P4GA 1DRBA 1U72A 3NXOA 4ELHA 4LAHX 1DAJA 3NXRA 1S3UA 3DL6A 3UM6A 3FY9X 2QK8A 2D5NA 3S9UA 2KGKA 4HA9A 3CD2A 1RB2A 3F0QX 4IXGX 4KYAA 3QL3A 3NZAX 4KNEA 1LY3A 3QLWA 3QL0A 5JA3A 4KL9A 1DDSA 3QGTA 2W9TA 4ELFA 4I13A 3FL9A 2D0KA 1DLRA 3DL5A 3JW5A 3QFXA 2DHFA 5FDAA 3JWMA 4XECX 3HBBA 1DR2A 3S7AA 1DG5A 2H2QA 1RX2A 5HVEA 2G6VA 3TD8A 4NX6A 3K45A 1RA9A 3SA1A 4HOEA 4HOGA 3FQVA 2OIPA 1DG8A 3SGYA 4HA7A 3TQAA 1RH3A 2JYBA 3NU0A 3S3VA 5HPBA 3CL9A 4OSGA 3IROA 2FZHA 4FHBA 4KY4A 4EILA 1BOZA 1AI9A 1RE7A 1RF7A 2INQA 4EIGA 2L28A 1LY4A 3FRAX 3RG9A 4PTJA 3HJ3A 1DR6A 4KM0A 4PSYA 3FQCA 3NZ9X 1IA2A 1HFPA 3NXVA 4QI9A 2BLBA 2BLCA 4X5JA 3KFYA 4X5FA 1RA1A 4KM2A 3SRQX 3SRUX 1TDRA 4XRBA 1DYHA 4H98A 4EIZA 4XE6X 1ZDRA 3FYWX 3K74A 2OBCA 3GYFA 5CC9A 4DP3A 1DHIA 4P68A 5EAJA 1DR3A 4DFRA 1RX9A 1DHFA 1J3IA 3NRRA 2B3ZA 3IX9A 4LAGX 3KJRA 2O7PA 1E26A 1DRHA 2W3BA 3KY8A 1DYIA 2ZZAA 3IRNA 2HXVA 8DFRA 1KMSA 4NX7A 4XT7A 3TQ9A 1MVSA 1DRAA 2FZIA 6DFRA 4QLFA 4ELGA 3NXXA 1PD9A 4QJCA 3FRBX 1MVTA 4FGGA 3DATA 2BL9A 4Q6AA 4KLXA 4QHVA 3FRDX 4X5GA 4XT8A 1JOMA 1AO8A 3SQYX 5E8QA 2W9SA 1M79A 1S3YA 3N0HA 3F91A 2LF1A 1VDRA 3KGYA 4KD7A 3F8YA 1RA2A 3FREX 3LG4A 4KJJA 1RX1A 1RX8A 4QLEA 3KJSA 2DRCA 4TU5X 1DR7A 4IXFX 1DHJA
chains in the Genus database with same CATH superfamily
3SRSX 3L3RA 4H96A 4M2XA 1IA4A 7DFRA 4Q0EA 5HQYA 3DAUA 3GHVA 1S3VA 1RX6A 3K2HA 3SR5X 4KY8A 4M6JA 2W3AA 1DG7A 1M7AA 4PSSA 4G95A 1DLSA 3FRFX 1OHKA 5HSUA 3OCHA 4M7UA 4KFJA 2HQPA 1RD7A 3SH2A 4LAEX 4ELBA 1RA3A 4RGCA 4H95A 2W3VA 3EEKA 3NXTA 1KLKA 3GHWA 1JOLA 1M78A 5ECCA 2ANQA 2XW7A 1D1GA 3M08A 1JUVA 4ECKA 5U27A 1CD2A 3TQ8A 1DR5A 1SEJA 3GI2A 1DR4A 3SRRX 3JWCA 3QLYA 3JSUA 4PTHA 3EIGA 1RX5A 4M7VA 4XT4A 3NXYA 1IA3A 3DG8A 3QYLA 2W3WA 5HI6A 2W9GA 3QLXA 3K47A 4KBNA 3TQBA 5HUIA 4PDJA 3ZPGA 1DIUA 4KJKA 3CSEA 1DYRA 2C2TA 3FQFA 5HT5A 1QZFA 4Q0DA 3EX8A 3EELA 3IA5A 4DPHA 3F0VX 1S3WA 4FGHA 3CLBA 4Q67A 3UM5A 3NZCX 1J3KA 1LUDA 3GHCA 3JWFA 3SAIA 4KJLA 1VJ3A 1RX4A 3D80A 4QLGA 3DGAA 4X5IA 3DFRA 1HFRA 4X5HA 4KAKA 3UM8A 1RC4A 1U70A 2HM9A 5HSRA 1PDBA 3DRCA 3JW3A 3QLSA 4DDRA 3FQZA 5DXVA 4I1NA 4G3MA 1J3JA 4P66A 5JG0X 3QLRA 1RG7A 3ROAA 2W9HA 5ECXA 4IXED 2CD2A 1RA8A 1IA1A 1U71A 3I3RA 2ANOA 3QG2A 4P3RA 3QLZA 3VCOA 3NTZA 3INVA 3SA2A 4XT6A 3EEMA 3F0SX 3SRWX 3NZ6X 1DYJA 1DR1A 3JVXA 2AZNA 3FQOA 4KEBA 2ITHA 3Q1HA 1CZ3A 2W3MA 4ELEA 4GH8A 3EEJA 3FYVX 4M6LA 5HF0X 2CIGA 3JWKA 5U26A 1DF7A 4DPDA 4G8ZX 3F0UX 1KMVA 5HT4A 3IRMA 1BZFA 5DFRA 1PD8A 4H97A 1RB3A 4P3QA 1DISA 4HOFA 2C2SA 1DRFA 1HFQA 4QJZD 1AOEA 3F0XX 3FQ0A 3QYOA 3ZPCA 3D84X 3FS6A 3NZDA 3RO9A 3F0BX 4EJ1A 3JTWA 5HVBA 2GD9A 2FZJA 3I8AX 3FL8A 1OHJA 4XT5A 3M09A 4OR7A 1RX3A 5HF2X 1DREA 3F8ZA 1DDRA 1YHOA 4LEKX 3E0BA 2BLAA 3IA4A 3NZBX 4CD2A 3R33A 3OAFA 4PSTA 1RX7A 4M6KA 5HQZA 3FY8X 5CCCA 2P4GA 1DRBA 1U72A 3NXOA 4ELHA 4LAHX 1DAJA 3NXRA 1S3UA 3DL6A 3UM6A 3FY9X 2QK8A 2D5NA 3S9UA 2KGKA 4HA9A 3CD2A 1RB2A 3F0QX 4IXGX 4KYAA 3QL3A 3NZAX 4KNEA 1LY3A 3QLWA 3QL0A 5JA3A 4KL9A 1DDSA 3QGTA 2W9TA 4ELFA 4I13A 3FL9A 2D0KA 1DLRA 3DL5A 3JW5A 3QFXA 2DHFA 5FDAA 3JWMA 4XECX 3HBBA 1DR2A 3S7AA 1DG5A 2H2QA 1RX2A 5HVEA 2G6VA 3TD8A 4NX6A 3K45A 1RA9A 3SA1A 4HOEA 4HOGA 3FQVA 2OIPA 1DG8A 3SGYA 4HA7A 3TQAA 1RH3A 2JYBA 3NU0A 3S3VA 5HPBA 3CL9A 4OSGA 3IROA 2FZHA 4FHBA 4KY4A 4EILA 1BOZA 1AI9A 1RE7A 1RF7A 2INQA 4EIGA 2L28A 1LY4A 3FRAX 3RG9A 4PTJA 3HJ3A 1DR6A 4KM0A 4PSYA 3FQCA 3NZ9X 1IA2A 1HFPA 3NXVA 4QI9A 2BLBA 2BLCA 4X5JA 3KFYA 4X5FA 1RA1A 4KM2A 3SRQX 3SRUX 1TDRA 4XRBA 1DYHA 4H98A 4EIZA 4XE6X 1ZDRA 3FYWX 3K74A 2OBCA 3GYFA 5CC9A 4DP3A 1DHIA 4P68A 5EAJA 1DR3A 4DFRA 1RX9A 1DHFA 1J3IA 3NRRA 2B3ZA 3IX9A 4LAGX 3KJRA 2O7PA 1E26A 1DRHA 2W3BA 3KY8A 1DYIA 2ZZAA 3IRNA 2HXVA 8DFRA 1KMSA 4NX7A 4XT7A 3TQ9A 1MVSA 1DRAA 2FZIA 6DFRA 4QLFA 4ELGA 3NXXA 1PD9A 4QJCA 3FRBX 1MVTA 4FGGA 3DATA 2BL9A 4Q6AA 4KLXA 4QHVA 3FRDX 4X5GA 4XT8A 1JOMA 1AO8A 3SQYX 5E8QA 2W9SA 1M79A 1S3YA 3N0HA 3F91A 2LF1A 1VDRA 3KGYA 4KD7A 3F8YA 1RA2A 3FREX 3LG4A 4KJJA 1RX1A 1RX8A 4QLEA 3KJSA 2DRCA 4TU5X 1DR7A 4IXFX 1DHJA
chains in the Genus database with same CATH topology
3SRSX 3L3RA 4H96A 4M2XA 1IA4A 7DFRA 4Q0EA 5HQYA 3DAUA 3GHVA 1S3VA 1RX6A 3K2HA 3SR5X 4KY8A 4M6JA 2W3AA 1DG7A 1M7AA 4PSSA 4G95A 1DLSA 3FRFX 1OHKA 5HSUA 3OCHA 4M7UA 4KFJA 2HQPA 1RD7A 3SH2A 4LAEX 4ELBA 1RA3A 4RGCA 4H95A 2W3VA 3EEKA 3NXTA 1KLKA 3GHWA 1JOLA 1M78A 5ECCA 2ANQA 2XW7A 1D1GA 3M08A 1JUVA 4ECKA 5U27A 1CD2A 3TQ8A 1DR5A 1SEJA 3GI2A 1DR4A 3SRRX 3JWCA 3QLYA 3JSUA 4PTHA 3EIGA 1RX5A 4M7VA 4XT4A 3NXYA 1IA3A 3DG8A 3QYLA 2W3WA 5HI6A 2W9GA 3QLXA 3K47A 4KBNA 3TQBA 5HUIA 4PDJA 3ZPGA 1DIUA 4KJKA 3CSEA 1DYRA 2C2TA 3FQFA 5HT5A 1QZFA 4Q0DA 3EX8A 3EELA 3IA5A 4DPHA 3F0VX 1S3WA 4FGHA 3CLBA 4Q67A 3UM5A 3NZCX 1J3KA 1LUDA 3GHCA 3JWFA 3SAIA 4KJLA 1VJ3A 1RX4A 3D80A 4QLGA 3DGAA 4X5IA 3DFRA 1HFRA 4X5HA 4KAKA 3UM8A 1RC4A 1U70A 2HM9A 5HSRA 1PDBA 3DRCA 3JW3A 3QLSA 4DDRA 3FQZA 5DXVA 4I1NA 4G3MA 1J3JA 4P66A 5JG0X 3QLRA 1RG7A 3ROAA 2W9HA 5ECXA 4IXED 2CD2A 1RA8A 1IA1A 1U71A 3I3RA 2ANOA 3QG2A 4P3RA 3QLZA 3VCOA 3NTZA 3INVA 3SA2A 4XT6A 3EEMA 3F0SX 3SRWX 3NZ6X 1DYJA 1DR1A 3JVXA 2AZNA 3FQOA 4KEBA 2ITHA 3Q1HA 1CZ3A 2W3MA 4ELEA 4GH8A 3EEJA 3FYVX 4M6LA 5HF0X 2CIGA 3JWKA 5U26A 1DF7A 4DPDA 4G8ZX 3F0UX 1KMVA 5HT4A 3IRMA 1BZFA 5DFRA 1PD8A 4H97A 1RB3A 4P3QA 1DISA 4HOFA 2C2SA 1DRFA 1HFQA 4QJZD 1AOEA 3F0XX 3FQ0A 3QYOA 3ZPCA 3D84X 3FS6A 3NZDA 3RO9A 3F0BX 4EJ1A 3JTWA 5HVBA 2GD9A 2FZJA 3I8AX 3FL8A 1OHJA 4XT5A 3M09A 4OR7A 1RX3A 5HF2X 1DREA 3F8ZA 1DDRA 1YHOA 4LEKX 3E0BA 2BLAA 3IA4A 3NZBX 4CD2A 3R33A 3OAFA 4PSTA 1RX7A 4M6KA 5HQZA 3FY8X 5CCCA 2P4GA 1DRBA 1U72A 3NXOA 4ELHA 4LAHX 1DAJA 3NXRA 1S3UA 3DL6A 3UM6A 3FY9X 2QK8A 2D5NA 3S9UA 2KGKA 4HA9A 3CD2A 1RB2A 3F0QX 4IXGX 4KYAA 3QL3A 3NZAX 4KNEA 1LY3A 3QLWA 3QL0A 5JA3A 4KL9A 1DDSA 3QGTA 2W9TA 4ELFA 4I13A 3FL9A 2D0KA 1DLRA 3DL5A 3JW5A 3QFXA 2DHFA 5FDAA 3JWMA 4XECX 3HBBA 1DR2A 3S7AA 1DG5A 2H2QA 1RX2A 5HVEA 2G6VA 3TD8A 4NX6A 3K45A 1RA9A 3SA1A 4HOEA 4HOGA 3FQVA 2OIPA 1DG8A 3SGYA 4HA7A 3TQAA 1RH3A 2JYBA 3NU0A 3S3VA 5HPBA 3CL9A 4OSGA 3IROA 2FZHA 4FHBA 4KY4A 4EILA 1BOZA 1AI9A 1RE7A 1RF7A 2INQA 4EIGA 2L28A 1LY4A 3FRAX 3RG9A 4PTJA 3HJ3A 1DR6A 4KM0A 4PSYA 3FQCA 3NZ9X 1IA2A 1HFPA 3NXVA 4QI9A 2BLBA 2BLCA 4X5JA 3KFYA 4X5FA 1RA1A 4KM2A 3SRQX 3SRUX 1TDRA 4XRBA 1DYHA 4H98A 4EIZA 4XE6X 1ZDRA 3FYWX 3K74A 2OBCA 3GYFA 5CC9A 4DP3A 1DHIA 4P68A 5EAJA 1DR3A 4DFRA 1RX9A 1DHFA 1J3IA 3NRRA 2B3ZA 3IX9A 4LAGX 3KJRA 2O7PA 1E26A 1DRHA 2W3BA 3KY8A 1DYIA 2ZZAA 3IRNA 2HXVA 8DFRA 1KMSA 4NX7A 4XT7A 3TQ9A 1MVSA 1DRAA 2FZIA 6DFRA 4QLFA 4ELGA 3NXXA 1PD9A 4QJCA 3FRBX 1MVTA 4FGGA 3DATA 2BL9A 4Q6AA 4KLXA 4QHVA 3FRDX 4X5GA 4XT8A 1JOMA 1AO8A 3SQYX 5E8QA 2W9SA 1M79A 1S3YA 3N0HA 3F91A 2LF1A 1VDRA 3KGYA 4KD7A 3F8YA 1RA2A 3FREX 3LG4A 4KJJA 1RX1A 1RX8A 4QLEA 3KJSA 2DRCA 4TU5X 1DR7A 4IXFX 1DHJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SRS X;  3L3R A;  4H96 A;  4M2X A;  1IA4 A;  7DFR A;  4Q0E A;  5HQY A;  3DAU A;  3GHV A;  1S3V A;  1RX6 A;  3K2H A;  3SR5 X;  4KY8 A;  4M6J A;  2W3A A;  1DG7 A;  1M7A A;  4PSS A;  4G95 A;  1DLS A;  3FRF X;  1OHK A;  5HSU A;  3OCH A;  4M7U A;  4KFJ A;  2HQP A;  1RD7 A;  3SH2 A;  4LAE X;  4ELB A;  1RA3 A;  4RGC A;  4H95 A;  2W3V A;  3EEK A;  3NXT A;  1KLK A;  3GHW A;  1JOL A;  1M78 A;  5ECC A;  2ANQ A;  2XW7 A;  1D1G A;  3M08 A;  1JUV A;  4ECK A;  5U27 A;  1CD2 A;  3TQ8 A;  1DR5 A;  1SEJ A;  3GI2 A;  1DR4 A;  3SRR X;  3JWC A;  3QLY A;  3JSU A;  4PTH A;  3EIG A;  1RX5 A;  4M7V A;  4XT4 A;  3NXY A;  1IA3 A;  3DG8 A;  3QYL A;  2W3W A;  5HI6 A;  2W9G A;  3QLX A;  3K47 A;  4KBN A;  3TQB A;  5HUI A;  4PDJ A;  3ZPG A;  1DIU A;  4KJK A;  3CSE A;  1DYR A;  2C2T A;  3FQF A;  5HT5 A;  1QZF A;  4Q0D A;  3EX8 A;  3EEL A;  3IA5 A;  4DPH A;  3F0V X;  1S3W A;  4FGH A;  3CLB A;  4Q67 A;  3UM5 A;  3NZC X;  1J3K A;  1LUD A;  3GHC A;  3JWF A;  3SAI A;  4KJL A;  1VJ3 A;  1RX4 A;  3D80 A;  4QLG A;  3DGA A;  4X5I A;  3DFR A;  1HFR A;  4X5H A;  4KAK A;  3UM8 A;  1RC4 A;  1U70 A;  2HM9 A;  5HSR A;  1PDB A;  3DRC A;  3JW3 A;  3QLS A;  4DDR A;  3FQZ A;  5DXV A;  4I1N A;  4G3M A;  1J3J A;  4P66 A;  5JG0 X;  3QLR A;  1RG7 A;  3ROA A;  2W9H A;  5ECX A;  4IXE D;  2CD2 A;  1RA8 A;  1IA1 A;  1U71 A;  3I3R A;  2ANO A;  3QG2 A;  4P3R A;  3QLZ A;  3VCO A;  3NTZ A;  3INV A;  3SA2 A;  4XT6 A;  3EEM A;  3F0S X;  3SRW X;  3NZ6 X;  1DYJ A;  1DR1 A;  3JVX A;  2AZN A;  3FQO A;  4KEB A;  2ITH A;  3Q1H A;  1CZ3 A;  2W3M A;  4ELE A;  4GH8 A;  3EEJ A;  3FYV X;  4M6L A;  5HF0 X;  2CIG A;  3JWK A;  5U26 A;  1DF7 A;  4DPD A;  4G8Z X;  3F0U X;  1KMV A;  5HT4 A;  3IRM A;  1BZF A;  5DFR A;  1PD8 A;  4H97 A;  1RB3 A;  4P3Q A;  1DIS A;  4HOF A;  2C2S A;  1DRF A;  1HFQ A;  4QJZ D;  1AOE A;  3F0X X;  3FQ0 A;  3QYO A;  3ZPC A;  3D84 X;  3FS6 A;  3NZD A;  3RO9 A;  3F0B X;  4EJ1 A;  3JTW A;  5HVB A;  2GD9 A;  2FZJ A;  3I8A X;  3FL8 A;  1OHJ A;  4XT5 A;  3M09 A;  4OR7 A;  1RX3 A;  5HF2 X;  1DRE A;  3F8Z A;  1DDR A;  1YHO A;  4LEK X;  3E0B A;  2BLA A;  3IA4 A;  3NZB X;  4CD2 A;  3R33 A;  3OAF A;  4PST A;  1RX7 A;  4M6K A;  5HQZ A;  3FY8 X;  5CCC A;  2P4G A;  1DRB A;  1U72 A;  3NXO A;  4ELH A;  4LAH X;  1DAJ A;  3NXR A;  1S3U A;  3DL6 A;  3UM6 A;  3FY9 X;  2QK8 A;  2D5N A;  3S9U A;  2KGK A;  4HA9 A;  3CD2 A;  1RB2 A;  3F0Q X;  4IXG X;  4KYA A;  3QL3 A;  3NZA X;  4KNE A;  1LY3 A;  3QLW A;  3QL0 A;  5JA3 A;  4KL9 A;  1DDS A;  3QGT A;  2W9T A;  4ELF A;  4I13 A;  3FL9 A;  2D0K A;  1DLR A;  3DL5 A;  3JW5 A;  3QFX A;  2DHF A;  5FDA A;  3JWM A;  4XEC X;  3HBB A;  1DR2 A;  3S7A A;  1DG5 A;  2H2Q A;  1RX2 A;  5HVE A;  2G6V A;  3TD8 A;  4NX6 A;  3K45 A;  1RA9 A;  3SA1 A;  4HOE A;  4HOG A;  3FQV A;  2OIP A;  1DG8 A;  3SGY A;  4HA7 A;  3TQA A;  1RH3 A;  2JYB A;  3NU0 A;  3S3V A;  5HPB A;  3CL9 A;  4OSG A;  3IRO A;  2FZH A;  4FHB A;  4KY4 A;  4EIL A;  1BOZ A;  1AI9 A;  1RE7 A;  1RF7 A;  2INQ A;  4EIG A;  2L28 A;  1LY4 A;  3FRA X;  3RG9 A;  4PTJ A;  3HJ3 A;  1DR6 A;  4KM0 A;  4PSY A;  3FQC A;  3NZ9 X;  1IA2 A;  1HFP A;  3NXV A;  4QI9 A;  2BLB A;  2BLC A;  4X5J A;  3KFY A;  4X5F A;  1RA1 A;  4KM2 A;  3SRQ X;  3SRU X;  1TDR A;  4XRB A;  1DYH A;  4H98 A;  4EIZ A;  4XE6 X;  1ZDR A;  3FYW X;  3K74 A;  2OBC A;  3GYF A;  5CC9 A;  4DP3 A;  1DHI A;  4P68 A;  5EAJ A;  1DR3 A;  4DFR A;  1RX9 A;  1DHF A;  1J3I A;  3NRR A;  2B3Z A;  3IX9 A;  4LAG X;  3KJR A;  2O7P A;  1E26 A;  1DRH A;  2W3B A;  3KY8 A;  1DYI A;  2ZZA A;  3IRN A;  2HXV A;  8DFR A;  1KMS A;  4NX7 A;  4XT7 A;  3TQ9 A;  1MVS A;  1DRA A;  2FZI A;  6DFR A;  4QLF A;  4ELG A;  3NXX A;  1PD9 A;  4QJC A;  3FRB X;  1MVT A;  4FGG A;  3DAT A;  2BL9 A;  4Q6A A;  4KLX A;  4QHV A;  3FRD X;  4X5G A;  4XT8 A;  1JOM A;  1AO8 A;  3SQY X;  5E8Q A;  2W9S A;  1M79 A;  1S3Y A;  3N0H A;  3F91 A;  2LF1 A;  1VDR A;  3KGY A;  4KD7 A;  3F8Y A;  1RA2 A;  3FRE X;  3LG4 A;  4KJJ A;  1RX1 A;  1RX8 A;  4QLE A;  3KJS A;  2DRC A;  4TU5 X;  1DR7 A;  4IXF X;  1DHJ A; 
#chains in the Genus database with same CATH topology
 3SRS X;  3L3R A;  4H96 A;  4M2X A;  1IA4 A;  7DFR A;  4Q0E A;  5HQY A;  3DAU A;  3GHV A;  1S3V A;  1RX6 A;  3K2H A;  3SR5 X;  4KY8 A;  4M6J A;  2W3A A;  1DG7 A;  1M7A A;  4PSS A;  4G95 A;  1DLS A;  3FRF X;  1OHK A;  5HSU A;  3OCH A;  4M7U A;  4KFJ A;  2HQP A;  1RD7 A;  3SH2 A;  4LAE X;  4ELB A;  1RA3 A;  4RGC A;  4H95 A;  2W3V A;  3EEK A;  3NXT A;  1KLK A;  3GHW A;  1JOL A;  1M78 A;  5ECC A;  2ANQ A;  2XW7 A;  1D1G A;  3M08 A;  1JUV A;  4ECK A;  5U27 A;  1CD2 A;  3TQ8 A;  1DR5 A;  1SEJ A;  3GI2 A;  1DR4 A;  3SRR X;  3JWC A;  3QLY A;  3JSU A;  4PTH A;  3EIG A;  1RX5 A;  4M7V A;  4XT4 A;  3NXY A;  1IA3 A;  3DG8 A;  3QYL A;  2W3W A;  5HI6 A;  2W9G A;  3QLX A;  3K47 A;  4KBN A;  3TQB A;  5HUI A;  4PDJ A;  3ZPG A;  1DIU A;  4KJK A;  3CSE A;  1DYR A;  2C2T A;  3FQF A;  5HT5 A;  1QZF A;  4Q0D A;  3EX8 A;  3EEL A;  3IA5 A;  4DPH A;  3F0V X;  1S3W A;  4FGH A;  3CLB A;  4Q67 A;  3UM5 A;  3NZC X;  1J3K A;  1LUD A;  3GHC A;  3JWF A;  3SAI A;  4KJL A;  1VJ3 A;  1RX4 A;  3D80 A;  4QLG A;  3DGA A;  4X5I A;  3DFR A;  1HFR A;  4X5H A;  4KAK A;  3UM8 A;  1RC4 A;  1U70 A;  2HM9 A;  5HSR A;  1PDB A;  3DRC A;  3JW3 A;  3QLS A;  4DDR A;  3FQZ A;  5DXV A;  4I1N A;  4G3M A;  1J3J A;  4P66 A;  5JG0 X;  3QLR A;  1RG7 A;  3ROA A;  2W9H A;  5ECX A;  4IXE D;  2CD2 A;  1RA8 A;  1IA1 A;  1U71 A;  3I3R A;  2ANO A;  3QG2 A;  4P3R A;  3QLZ A;  3VCO A;  3NTZ A;  3INV A;  3SA2 A;  4XT6 A;  3EEM A;  3F0S X;  3SRW X;  3NZ6 X;  1DYJ A;  1DR1 A;  3JVX A;  2AZN A;  3FQO A;  4KEB A;  2ITH A;  3Q1H A;  1CZ3 A;  2W3M A;  4ELE A;  4GH8 A;  3EEJ A;  3FYV X;  4M6L A;  5HF0 X;  2CIG A;  3JWK A;  5U26 A;  1DF7 A;  4DPD A;  4G8Z X;  3F0U X;  1KMV A;  5HT4 A;  3IRM A;  1BZF A;  5DFR A;  1PD8 A;  4H97 A;  1RB3 A;  4P3Q A;  1DIS A;  4HOF A;  2C2S A;  1DRF A;  1HFQ A;  4QJZ D;  1AOE A;  3F0X X;  3FQ0 A;  3QYO A;  3ZPC A;  3D84 X;  3FS6 A;  3NZD A;  3RO9 A;  3F0B X;  4EJ1 A;  3JTW A;  5HVB A;  2GD9 A;  2FZJ A;  3I8A X;  3FL8 A;  1OHJ A;  4XT5 A;  3M09 A;  4OR7 A;  1RX3 A;  5HF2 X;  1DRE A;  3F8Z A;  1DDR A;  1YHO A;  4LEK X;  3E0B A;  2BLA A;  3IA4 A;  3NZB X;  4CD2 A;  3R33 A;  3OAF A;  4PST A;  1RX7 A;  4M6K A;  5HQZ A;  3FY8 X;  5CCC A;  2P4G A;  1DRB A;  1U72 A;  3NXO A;  4ELH A;  4LAH X;  1DAJ A;  3NXR A;  1S3U A;  3DL6 A;  3UM6 A;  3FY9 X;  2QK8 A;  2D5N A;  3S9U A;  2KGK A;  4HA9 A;  3CD2 A;  1RB2 A;  3F0Q X;  4IXG X;  4KYA A;  3QL3 A;  3NZA X;  4KNE A;  1LY3 A;  3QLW A;  3QL0 A;  5JA3 A;  4KL9 A;  1DDS A;  3QGT A;  2W9T A;  4ELF A;  4I13 A;  3FL9 A;  2D0K A;  1DLR A;  3DL5 A;  3JW5 A;  3QFX A;  2DHF A;  5FDA A;  3JWM A;  4XEC X;  3HBB A;  1DR2 A;  3S7A A;  1DG5 A;  2H2Q A;  1RX2 A;  5HVE A;  2G6V A;  3TD8 A;  4NX6 A;  3K45 A;  1RA9 A;  3SA1 A;  4HOE A;  4HOG A;  3FQV A;  2OIP A;  1DG8 A;  3SGY A;  4HA7 A;  3TQA A;  1RH3 A;  2JYB A;  3NU0 A;  3S3V A;  5HPB A;  3CL9 A;  4OSG A;  3IRO A;  2FZH A;  4FHB A;  4KY4 A;  4EIL A;  1BOZ A;  1AI9 A;  1RE7 A;  1RF7 A;  2INQ A;  4EIG A;  2L28 A;  1LY4 A;  3FRA X;  3RG9 A;  4PTJ A;  3HJ3 A;  1DR6 A;  4KM0 A;  4PSY A;  3FQC A;  3NZ9 X;  1IA2 A;  1HFP A;  3NXV A;  4QI9 A;  2BLB A;  2BLC A;  4X5J A;  3KFY A;  4X5F A;  1RA1 A;  4KM2 A;  3SRQ X;  3SRU X;  1TDR A;  4XRB A;  1DYH A;  4H98 A;  4EIZ A;  4XE6 X;  1ZDR A;  3FYW X;  3K74 A;  2OBC A;  3GYF A;  5CC9 A;  4DP3 A;  1DHI A;  4P68 A;  5EAJ A;  1DR3 A;  4DFR A;  1RX9 A;  1DHF A;  1J3I A;  3NRR A;  2B3Z A;  3IX9 A;  4LAG X;  3KJR A;  2O7P A;  1E26 A;  1DRH A;  2W3B A;  3KY8 A;  1DYI A;  2ZZA A;  3IRN A;  2HXV A;  8DFR A;  1KMS A;  4NX7 A;  4XT7 A;  3TQ9 A;  1MVS A;  1DRA A;  2FZI A;  6DFR A;  4QLF A;  4ELG A;  3NXX A;  1PD9 A;  4QJC A;  3FRB X;  1MVT A;  4FGG A;  3DAT A;  2BL9 A;  4Q6A A;  4KLX A;  4QHV A;  3FRD X;  4X5G A;  4XT8 A;  1JOM A;  1AO8 A;  3SQY X;  5E8Q A;  2W9S A;  1M79 A;  1S3Y A;  3N0H A;  3F91 A;  2LF1 A;  1VDR A;  3KGY A;  4KD7 A;  3F8Y A;  1RA2 A;  3FRE X;  3LG4 A;  4KJJ A;  1RX1 A;  1RX8 A;  4QLE A;  3KJS A;  2DRC A;  4TU5 X;  1DR7 A;  4IXF X;  1DHJ A; 
#chains in the Genus database with same CATH homology
 3SRS X;  3L3R A;  4H96 A;  4M2X A;  1IA4 A;  7DFR A;  4Q0E A;  5HQY A;  3DAU A;  3GHV A;  1S3V A;  1RX6 A;  3K2H A;  3SR5 X;  4KY8 A;  4M6J A;  2W3A A;  1DG7 A;  1M7A A;  4PSS A;  4G95 A;  1DLS A;  3FRF X;  1OHK A;  5HSU A;  3OCH A;  4M7U A;  4KFJ A;  2HQP A;  1RD7 A;  3SH2 A;  4LAE X;  4ELB A;  1RA3 A;  4RGC A;  4H95 A;  2W3V A;  3EEK A;  3NXT A;  1KLK A;  3GHW A;  1JOL A;  1M78 A;  5ECC A;  2ANQ A;  2XW7 A;  1D1G A;  3M08 A;  1JUV A;  4ECK A;  5U27 A;  1CD2 A;  3TQ8 A;  1DR5 A;  1SEJ A;  3GI2 A;  1DR4 A;  3SRR X;  3JWC A;  3QLY A;  3JSU A;  4PTH A;  3EIG A;  1RX5 A;  4M7V A;  4XT4 A;  3NXY A;  1IA3 A;  3DG8 A;  3QYL A;  2W3W A;  5HI6 A;  2W9G A;  3QLX A;  3K47 A;  4KBN A;  3TQB A;  5HUI A;  4PDJ A;  3ZPG A;  1DIU A;  4KJK A;  3CSE A;  1DYR A;  2C2T A;  3FQF A;  5HT5 A;  1QZF A;  4Q0D A;  3EX8 A;  3EEL A;  3IA5 A;  4DPH A;  3F0V X;  1S3W A;  4FGH A;  3CLB A;  4Q67 A;  3UM5 A;  3NZC X;  1J3K A;  1LUD A;  3GHC A;  3JWF A;  3SAI A;  4KJL A;  1VJ3 A;  1RX4 A;  3D80 A;  4QLG A;  3DGA A;  4X5I A;  3DFR A;  1HFR A;  4X5H A;  4KAK A;  3UM8 A;  1RC4 A;  1U70 A;  2HM9 A;  5HSR A;  1PDB A;  3DRC A;  3JW3 A;  3QLS A;  4DDR A;  3FQZ A;  5DXV A;  4I1N A;  4G3M A;  1J3J A;  4P66 A;  5JG0 X;  3QLR A;  1RG7 A;  3ROA A;  2W9H A;  5ECX A;  4IXE D;  2CD2 A;  1RA8 A;  1IA1 A;  1U71 A;  3I3R A;  2ANO A;  3QG2 A;  4P3R A;  3QLZ A;  3VCO A;  3NTZ A;  3INV A;  3SA2 A;  4XT6 A;  3EEM A;  3F0S X;  3SRW X;  3NZ6 X;  1DYJ A;  1DR1 A;  3JVX A;  2AZN A;  3FQO A;  4KEB A;  2ITH A;  3Q1H A;  1CZ3 A;  2W3M A;  4ELE A;  4GH8 A;  3EEJ A;  3FYV X;  4M6L A;  5HF0 X;  2CIG A;  3JWK A;  5U26 A;  1DF7 A;  4DPD A;  4G8Z X;  3F0U X;  1KMV A;  5HT4 A;  3IRM A;  1BZF A;  5DFR A;  1PD8 A;  4H97 A;  1RB3 A;  4P3Q A;  1DIS A;  4HOF A;  2C2S A;  1DRF A;  1HFQ A;  4QJZ D;  1AOE A;  3F0X X;  3FQ0 A;  3QYO A;  3ZPC A;  3D84 X;  3FS6 A;  3NZD A;  3RO9 A;  3F0B X;  4EJ1 A;  3JTW A;  5HVB A;  2GD9 A;  2FZJ A;  3I8A X;  3FL8 A;  1OHJ A;  4XT5 A;  3M09 A;  4OR7 A;  1RX3 A;  5HF2 X;  1DRE A;  3F8Z A;  1DDR A;  1YHO A;  4LEK X;  3E0B A;  2BLA A;  3IA4 A;  3NZB X;  4CD2 A;  3R33 A;  3OAF A;  4PST A;  1RX7 A;  4M6K A;  5HQZ A;  3FY8 X;  5CCC A;  2P4G A;  1DRB A;  1U72 A;  3NXO A;  4ELH A;  4LAH X;  1DAJ A;  3NXR A;  1S3U A;  3DL6 A;  3UM6 A;  3FY9 X;  2QK8 A;  2D5N A;  3S9U A;  2KGK A;  4HA9 A;  3CD2 A;  1RB2 A;  3F0Q X;  4IXG X;  4KYA A;  3QL3 A;  3NZA X;  4KNE A;  1LY3 A;  3QLW A;  3QL0 A;  5JA3 A;  4KL9 A;  1DDS A;  3QGT A;  2W9T A;  4ELF A;  4I13 A;  3FL9 A;  2D0K A;  1DLR A;  3DL5 A;  3JW5 A;  3QFX A;  2DHF A;  5FDA A;  3JWM A;  4XEC X;  3HBB A;  1DR2 A;  3S7A A;  1DG5 A;  2H2Q A;  1RX2 A;  5HVE A;  2G6V A;  3TD8 A;  4NX6 A;  3K45 A;  1RA9 A;  3SA1 A;  4HOE A;  4HOG A;  3FQV A;  2OIP A;  1DG8 A;  3SGY A;  4HA7 A;  3TQA A;  1RH3 A;  2JYB A;  3NU0 A;  3S3V A;  5HPB A;  3CL9 A;  4OSG A;  3IRO A;  2FZH A;  4FHB A;  4KY4 A;  4EIL A;  1BOZ A;  1AI9 A;  1RE7 A;  1RF7 A;  2INQ A;  4EIG A;  2L28 A;  1LY4 A;  3FRA X;  3RG9 A;  4PTJ A;  3HJ3 A;  1DR6 A;  4KM0 A;  4PSY A;  3FQC A;  3NZ9 X;  1IA2 A;  1HFP A;  3NXV A;  4QI9 A;  2BLB A;  2BLC A;  4X5J A;  3KFY A;  4X5F A;  1RA1 A;  4KM2 A;  3SRQ X;  3SRU X;  1TDR A;  4XRB A;  1DYH A;  4H98 A;  4EIZ A;  4XE6 X;  1ZDR A;  3FYW X;  3K74 A;  2OBC A;  3GYF A;  5CC9 A;  4DP3 A;  1DHI A;  4P68 A;  5EAJ A;  1DR3 A;  4DFR A;  1RX9 A;  1DHF A;  1J3I A;  3NRR A;  2B3Z A;  3IX9 A;  4LAG X;  3KJR A;  2O7P A;  1E26 A;  1DRH A;  2W3B A;  3KY8 A;  1DYI A;  2ZZA A;  3IRN A;  2HXV A;  8DFR A;  1KMS A;  4NX7 A;  4XT7 A;  3TQ9 A;  1MVS A;  1DRA A;  2FZI A;  6DFR A;  4QLF A;  4ELG A;  3NXX A;  1PD9 A;  4QJC A;  3FRB X;  1MVT A;  4FGG A;  3DAT A;  2BL9 A;  4Q6A A;  4KLX A;  4QHV A;  3FRD X;  4X5G A;  4XT8 A;  1JOM A;  1AO8 A;  3SQY X;  5E8Q A;  2W9S A;  1M79 A;  1S3Y A;  3N0H A;  3F91 A;  2LF1 A;  1VDR A;  3KGY A;  4KD7 A;  3F8Y A;  1RA2 A;  3FRE X;  3LG4 A;  4KJJ A;  1RX1 A;  1RX8 A;  4QLE A;  3KJS A;  2DRC A;  4TU5 X;  1DR7 A;  4IXF X;  1DHJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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