1HFPA

Comparison of ternary crystal complexes of human dihydrofolate reductase with nadph and a classical antitumor furopyrimdine
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEGRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
pubmed rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 48
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1997-11-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1hfpA00
3JW3A 4EJ1A 1YHOA 3FQCA 1PD9A 1ZDRA 3EEMA 3NZ9X 3DL5A 4KYAA 1DHJA 2W9SA 2G6VA 5U27A 4KJLA 4IXED 5HVEA 4I13A 3KFYA 1RH3A 3I8AX 3IRMA 3FQVA 1AOEA 1HFRA 1OHKA 1RX1A 3GHVA 3TQ8A 3JWCA 1RX9A 1LUDA 1IA2A 2FZHA 1SEJA 4TU5X 3K74A 4KFJA 4KY4A 3TQ9A 4LAEX 1PDBA 4IXGX 3SRSX 5HT5A 4XT8A 2BL9A 4DPDA 4QJZD 3EELA 1E26A 3KY8A 4KBNA 5HQZA 1QZFA 3QYLA 4P3RA 3D80A 4EILA 3QGTA 2FZJA 3JVXA 3KGYA 5CC9A 4NX7A 3F0QX 1DAJA 3GHCA 5ECXA 4P68A 3NTZA 1DR2A 1BZFA 4HOGA 1D1GA 4EIZA 1VJ3A 3FL9A 3ROAA 1U70A 1VDRA 2ZZAA 4X5IA 2C2SA 4XT6A 3NXRA 4FHBA 4Q6AA 4QLEA 4H96A 3ZPGA 4DFRA 2ANQA 3QL3A 4ECKA 4KJJA 3FQZA 3DL6A 3OCHA 1PD8A 4HA9A 1DYJA 3FQFA 1RX3A 1RA2A 3INVA 3IA4A 4H98A 5HI6A 1RX4A 4KJKA 1DG8A 1DISA 2HQPA 2ANOA 4X5FA 4ELGA 2O7PA 3FY9X 3JWMA 4XRBA 3GYFA 5JA3A 5HVBA 4QLGA 2W3BA 4KAKA 2W3VA 3IRNA 1JOMA 3NZCX 1IA1A 1RF7A 2BLBA 3FYVX 4QI9A 3SH2A 3KJSA 3SAIA 4DDRA 1RB2A 1DIUA 3RO9A 3ZPCA 3F91A 3QG2A 1DG7A 5HPBA 5HSRA 4LAGX 4KM2A 2W9HA 4ELBA 4XE6X 3GI2A 2DHFA 1RE7A 1DREA 2INQA 3FQOA 5HSUA 5CCCA 3UM8A 3QLYA 1MVTA 3DG8A 3SQYX 3K47A 1RB3A 4PDJA 4M6KA 4PSYA 1DYIA 4LEKX 1JOLA 1OHJA 4KL9A 5FDAA 2P4GA 1DYRA 1RX8A 3FY8X 7DFRA 1S3WA 1RX5A 5EAJA 5DFRA 5JG0X 3M09A 1DDSA 3IA5A 1U72A 2OBCA 1KLKA 4M7VA 2H2QA 1S3UA 1RX2A 3FYWX 3E0BA 1DR4A 4KLXA 4Q67A 3VCOA 3DFRA 4PTHA 4PTJA 1RA3A 3S9UA 1DR3A 3FRAX 3EEJA 1DYHA 3SGYA 4PSTA 5HF0X 3NZ6X 1MVSA 4P66A 2LF1A 4IXFX 1DDRA 2OIPA 1BOZA 4QJCA 3SR5X 4LAHX 3QLXA 5ECCA 2W3MA 2W3AA 1M79A 1U71A 1DR7A 4ELEA 4FGHA 4KY8A 3M08A 1DHIA 3NXXA 1IA4A 4XECX 3CSEA 1TDRA 4KM0A 3DGAA 3NZBX 4DPHA 4HOFA 3QLZA 3FRFX 3DAUA 2QK8A 2JYBA 3FS6A 3IX9A 3JSUA 2B3ZA 2HXVA 4G8ZX 2L28A 3SRRX 3FRBX 2KGKA 1RA8A 3KJRA 3JTWA 5DXVA 3SA1A 3SA2A 3I3RA 2D0KA 6DFRA 4RGCA 4G3MA 4HOEA 1DRBA 1DRHA 3FREX 1DRFA 1J3JA 3HBBA 4I1NA 2ITHA 3NXYA 2CIGA 1S3YA 5HT4A 4X5HA 1RX6A 3FL8A 5HQYA 1AI9A 3JWFA 3CD2A 4P3QA 1LY3A 1DLRA 1RA1A 3EIGA 1KMVA 3HJ3A 3UM6A 3EEKA 1S3VA 4ELFA 2W3WA 2W9GA 3NXTA 2HM9A 3K2HA 3R33A 1RA9A 3D84X 1DF7A 4KNEA 3L3RA 1LY4A 4M7UA 3QLRA 2DRCA 4Q0DA 1RD7A 3NZDA 4G95A 4XT4A 3CL9A 1JUVA 1RC4A 5HUIA 3S7AA 3QL0A 4X5GA 3QFXA 3SRQX 4GH8A 3NRRA 1CZ3A 1DLSA 3NXOA 3QLSA 2GD9A 3JW5A 3RG9A 2BLCA 3FQ0A 2W9TA 2BLAA 4FGGA 1J3KA 4KD7A 3LG4A 1DR6A 3GHWA 3SRWX 3N0HA 4CD2A 1M78A 1IA3A 3QYOA 3UM5A 5HF2X 2XW7A 1HFQA 4M6JA 2C2TA 3F0BX 3SRUX 2FZIA 3CLBA 4NX6A 4EIGA 1CD2A 4QHVA 4XT5A 3Q1HA 3TQBA 4XT7A 1DG5A 4ELHA 1DR1A 3K45A 4X5JA 1RG7A 1M7AA 3F0XX 1J3IA 4QLFA 1HFPA 3S3VA 3F8ZA 8DFRA 4KEBA 5E8QA 2CD2A 3DATA 3EX8A 3F8YA 4OSGA 3F0VX 2D5NA 3NU0A 4Q0EA 3NZAX 3NXVA 1KMSA 3QLWA 1DR5A 4HA7A 1DHFA 1RX7A 3DRCA 1AO8A 4M6LA 4M2XA 3FRDX 4OR7A 4DP3A 2AZNA 5U26A 4H95A 3OAFA 3TQAA 3F0UX 3JWKA 3F0SX 4PSSA 1DRAA 3IROA 3TD8A 4H97A
chains in the Genus database with same CATH superfamily
3JW3A 4EJ1A 1YHOA 3FQCA 1PD9A 1ZDRA 3EEMA 3NZ9X 3DL5A 4KYAA 1DHJA 2W9SA 2G6VA 5U27A 4KJLA 4IXED 5HVEA 4I13A 3KFYA 1RH3A 3I8AX 3IRMA 3FQVA 1AOEA 1HFRA 1OHKA 1RX1A 3GHVA 3TQ8A 3JWCA 1RX9A 1LUDA 1IA2A 2FZHA 1SEJA 4TU5X 3K74A 4KFJA 4KY4A 3TQ9A 4LAEX 1PDBA 4IXGX 3SRSX 5HT5A 4XT8A 2BL9A 4DPDA 4QJZD 3EELA 1E26A 3KY8A 4KBNA 5HQZA 1QZFA 3QYLA 4P3RA 3D80A 4EILA 3QGTA 2FZJA 3JVXA 3KGYA 5CC9A 4NX7A 3F0QX 1DAJA 3GHCA 5ECXA 4P68A 3NTZA 1DR2A 1BZFA 4HOGA 1D1GA 4EIZA 1VJ3A 3FL9A 3ROAA 1U70A 1VDRA 2ZZAA 4X5IA 2C2SA 4XT6A 3NXRA 4FHBA 4Q6AA 4QLEA 4H96A 3ZPGA 4DFRA 2ANQA 3QL3A 4ECKA 4KJJA 3FQZA 3DL6A 3OCHA 1PD8A 4HA9A 1DYJA 3FQFA 1RX3A 1RA2A 3INVA 3IA4A 4H98A 5HI6A 1RX4A 4KJKA 1DG8A 1DISA 2HQPA 2ANOA 4X5FA 4ELGA 2O7PA 3FY9X 3JWMA 4XRBA 3GYFA 5JA3A 5HVBA 4QLGA 2W3BA 4KAKA 2W3VA 3IRNA 1JOMA 3NZCX 1IA1A 1RF7A 2BLBA 3FYVX 4QI9A 3SH2A 3KJSA 3SAIA 4DDRA 1RB2A 1DIUA 3RO9A 3ZPCA 3F91A 3QG2A 1DG7A 5HPBA 5HSRA 4LAGX 4KM2A 2W9HA 4ELBA 4XE6X 3GI2A 2DHFA 1RE7A 1DREA 2INQA 3FQOA 5HSUA 5CCCA 3UM8A 3QLYA 1MVTA 3DG8A 3SQYX 3K47A 1RB3A 4PDJA 4M6KA 4PSYA 1DYIA 4LEKX 1JOLA 1OHJA 4KL9A 5FDAA 2P4GA 1DYRA 1RX8A 3FY8X 7DFRA 1S3WA 1RX5A 5EAJA 5DFRA 5JG0X 3M09A 1DDSA 3IA5A 1U72A 2OBCA 1KLKA 4M7VA 2H2QA 1S3UA 1RX2A 3FYWX 3E0BA 1DR4A 4KLXA 4Q67A 3VCOA 3DFRA 4PTHA 4PTJA 1RA3A 3S9UA 1DR3A 3FRAX 3EEJA 1DYHA 3SGYA 4PSTA 5HF0X 3NZ6X 1MVSA 4P66A 2LF1A 4IXFX 1DDRA 2OIPA 1BOZA 4QJCA 3SR5X 4LAHX 3QLXA 5ECCA 2W3MA 2W3AA 1M79A 1U71A 1DR7A 4ELEA 4FGHA 4KY8A 3M08A 1DHIA 3NXXA 1IA4A 4XECX 3CSEA 1TDRA 4KM0A 3DGAA 3NZBX 4DPHA 4HOFA 3QLZA 3FRFX 3DAUA 2QK8A 2JYBA 3FS6A 3IX9A 3JSUA 2B3ZA 2HXVA 4G8ZX 2L28A 3SRRX 3FRBX 2KGKA 1RA8A 3KJRA 3JTWA 5DXVA 3SA1A 3SA2A 3I3RA 2D0KA 6DFRA 4RGCA 4G3MA 4HOEA 1DRBA 1DRHA 3FREX 1DRFA 1J3JA 3HBBA 4I1NA 2ITHA 3NXYA 2CIGA 1S3YA 5HT4A 4X5HA 1RX6A 3FL8A 5HQYA 1AI9A 3JWFA 3CD2A 4P3QA 1LY3A 1DLRA 1RA1A 3EIGA 1KMVA 3HJ3A 3UM6A 3EEKA 1S3VA 4ELFA 2W3WA 2W9GA 3NXTA 2HM9A 3K2HA 3R33A 1RA9A 3D84X 1DF7A 4KNEA 3L3RA 1LY4A 4M7UA 3QLRA 2DRCA 4Q0DA 1RD7A 3NZDA 4G95A 4XT4A 3CL9A 1JUVA 1RC4A 5HUIA 3S7AA 3QL0A 4X5GA 3QFXA 3SRQX 4GH8A 3NRRA 1CZ3A 1DLSA 3NXOA 3QLSA 2GD9A 3JW5A 3RG9A 2BLCA 3FQ0A 2W9TA 2BLAA 4FGGA 1J3KA 4KD7A 3LG4A 1DR6A 3GHWA 3SRWX 3N0HA 4CD2A 1M78A 1IA3A 3QYOA 3UM5A 5HF2X 2XW7A 1HFQA 4M6JA 2C2TA 3F0BX 3SRUX 2FZIA 3CLBA 4NX6A 4EIGA 1CD2A 4QHVA 4XT5A 3Q1HA 3TQBA 4XT7A 1DG5A 4ELHA 1DR1A 3K45A 4X5JA 1RG7A 1M7AA 3F0XX 1J3IA 4QLFA 1HFPA 3S3VA 3F8ZA 8DFRA 4KEBA 5E8QA 2CD2A 3DATA 3EX8A 3F8YA 4OSGA 3F0VX 2D5NA 3NU0A 4Q0EA 3NZAX 3NXVA 1KMSA 3QLWA 1DR5A 4HA7A 1DHFA 1RX7A 3DRCA 1AO8A 4M6LA 4M2XA 3FRDX 4OR7A 4DP3A 2AZNA 5U26A 4H95A 3OAFA 3TQAA 3F0UX 3JWKA 3F0SX 4PSSA 1DRAA 3IROA 3TD8A 4H97A
chains in the Genus database with same CATH topology
3JW3A 4EJ1A 1YHOA 3FQCA 1PD9A 1ZDRA 3EEMA 3NZ9X 3DL5A 4KYAA 1DHJA 2W9SA 2G6VA 5U27A 4KJLA 4IXED 5HVEA 4I13A 3KFYA 1RH3A 3I8AX 3IRMA 3FQVA 1AOEA 1HFRA 1OHKA 1RX1A 3GHVA 3TQ8A 3JWCA 1RX9A 1LUDA 1IA2A 2FZHA 1SEJA 4TU5X 3K74A 4KFJA 4KY4A 3TQ9A 4LAEX 1PDBA 4IXGX 3SRSX 5HT5A 4XT8A 2BL9A 4DPDA 4QJZD 3EELA 1E26A 3KY8A 4KBNA 5HQZA 1QZFA 3QYLA 4P3RA 3D80A 4EILA 3QGTA 2FZJA 3JVXA 3KGYA 5CC9A 4NX7A 3F0QX 1DAJA 3GHCA 5ECXA 4P68A 3NTZA 1DR2A 1BZFA 4HOGA 1D1GA 4EIZA 1VJ3A 3FL9A 3ROAA 1U70A 1VDRA 2ZZAA 4X5IA 2C2SA 4XT6A 3NXRA 4FHBA 4Q6AA 4QLEA 4H96A 3ZPGA 4DFRA 2ANQA 3QL3A 4ECKA 4KJJA 3FQZA 3DL6A 3OCHA 1PD8A 4HA9A 1DYJA 3FQFA 1RX3A 1RA2A 3INVA 3IA4A 4H98A 5HI6A 1RX4A 4KJKA 1DG8A 1DISA 2HQPA 2ANOA 4X5FA 4ELGA 2O7PA 3FY9X 3JWMA 4XRBA 3GYFA 5JA3A 5HVBA 4QLGA 2W3BA 4KAKA 2W3VA 3IRNA 1JOMA 3NZCX 1IA1A 1RF7A 2BLBA 3FYVX 4QI9A 3SH2A 3KJSA 3SAIA 4DDRA 1RB2A 1DIUA 3RO9A 3ZPCA 3F91A 3QG2A 1DG7A 5HPBA 5HSRA 4LAGX 4KM2A 2W9HA 4ELBA 4XE6X 3GI2A 2DHFA 1RE7A 1DREA 2INQA 3FQOA 5HSUA 5CCCA 3UM8A 3QLYA 1MVTA 3DG8A 3SQYX 3K47A 1RB3A 4PDJA 4M6KA 4PSYA 1DYIA 4LEKX 1JOLA 1OHJA 4KL9A 5FDAA 2P4GA 1DYRA 1RX8A 3FY8X 7DFRA 1S3WA 1RX5A 5EAJA 5DFRA 5JG0X 3M09A 1DDSA 3IA5A 1U72A 2OBCA 1KLKA 4M7VA 2H2QA 1S3UA 1RX2A 3FYWX 3E0BA 1DR4A 4KLXA 4Q67A 3VCOA 3DFRA 4PTHA 4PTJA 1RA3A 3S9UA 1DR3A 3FRAX 3EEJA 1DYHA 3SGYA 4PSTA 5HF0X 3NZ6X 1MVSA 4P66A 2LF1A 4IXFX 1DDRA 2OIPA 1BOZA 4QJCA 3SR5X 4LAHX 3QLXA 5ECCA 2W3MA 2W3AA 1M79A 1U71A 1DR7A 4ELEA 4FGHA 4KY8A 3M08A 1DHIA 3NXXA 1IA4A 4XECX 3CSEA 1TDRA 4KM0A 3DGAA 3NZBX 4DPHA 4HOFA 3QLZA 3FRFX 3DAUA 2QK8A 2JYBA 3FS6A 3IX9A 3JSUA 2B3ZA 2HXVA 4G8ZX 2L28A 3SRRX 3FRBX 2KGKA 1RA8A 3KJRA 3JTWA 5DXVA 3SA1A 3SA2A 3I3RA 2D0KA 6DFRA 4RGCA 4G3MA 4HOEA 1DRBA 1DRHA 3FREX 1DRFA 1J3JA 3HBBA 4I1NA 2ITHA 3NXYA 2CIGA 1S3YA 5HT4A 4X5HA 1RX6A 3FL8A 5HQYA 1AI9A 3JWFA 3CD2A 4P3QA 1LY3A 1DLRA 1RA1A 3EIGA 1KMVA 3HJ3A 3UM6A 3EEKA 1S3VA 4ELFA 2W3WA 2W9GA 3NXTA 2HM9A 3K2HA 3R33A 1RA9A 3D84X 1DF7A 4KNEA 3L3RA 1LY4A 4M7UA 3QLRA 2DRCA 4Q0DA 1RD7A 3NZDA 4G95A 4XT4A 3CL9A 1JUVA 1RC4A 5HUIA 3S7AA 3QL0A 4X5GA 3QFXA 3SRQX 4GH8A 3NRRA 1CZ3A 1DLSA 3NXOA 3QLSA 2GD9A 3JW5A 3RG9A 2BLCA 3FQ0A 2W9TA 2BLAA 4FGGA 1J3KA 4KD7A 3LG4A 1DR6A 3GHWA 3SRWX 3N0HA 4CD2A 1M78A 1IA3A 3QYOA 3UM5A 5HF2X 2XW7A 1HFQA 4M6JA 2C2TA 3F0BX 3SRUX 2FZIA 3CLBA 4NX6A 4EIGA 1CD2A 4QHVA 4XT5A 3Q1HA 3TQBA 4XT7A 1DG5A 4ELHA 1DR1A 3K45A 4X5JA 1RG7A 1M7AA 3F0XX 1J3IA 4QLFA 1HFPA 3S3VA 3F8ZA 8DFRA 4KEBA 5E8QA 2CD2A 3DATA 3EX8A 3F8YA 4OSGA 3F0VX 2D5NA 3NU0A 4Q0EA 3NZAX 3NXVA 1KMSA 3QLWA 1DR5A 4HA7A 1DHFA 1RX7A 3DRCA 1AO8A 4M6LA 4M2XA 3FRDX 4OR7A 4DP3A 2AZNA 5U26A 4H95A 3OAFA 3TQAA 3F0UX 3JWKA 3F0SX 4PSSA 1DRAA 3IROA 3TD8A 4H97A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3JW3 A;  4EJ1 A;  1YHO A;  3FQC A;  1PD9 A;  1ZDR A;  3EEM A;  3NZ9 X;  3DL5 A;  4KYA A;  1DHJ A;  2W9S A;  2G6V A;  5U27 A;  4KJL A;  4IXE D;  5HVE A;  4I13 A;  3KFY A;  1RH3 A;  3I8A X;  3IRM A;  3FQV A;  1AOE A;  1HFR A;  1OHK A;  1RX1 A;  3GHV A;  3TQ8 A;  3JWC A;  1RX9 A;  1LUD A;  1IA2 A;  2FZH A;  1SEJ A;  4TU5 X;  3K74 A;  4KFJ A;  4KY4 A;  3TQ9 A;  4LAE X;  1PDB A;  4IXG X;  3SRS X;  5HT5 A;  4XT8 A;  2BL9 A;  4DPD A;  4QJZ D;  3EEL A;  1E26 A;  3KY8 A;  4KBN A;  5HQZ A;  1QZF A;  3QYL A;  4P3R A;  3D80 A;  4EIL A;  3QGT A;  2FZJ A;  3JVX A;  3KGY A;  5CC9 A;  4NX7 A;  3F0Q X;  1DAJ A;  3GHC A;  5ECX A;  4P68 A;  3NTZ A;  1DR2 A;  1BZF A;  4HOG A;  1D1G A;  4EIZ A;  1VJ3 A;  3FL9 A;  3ROA A;  1U70 A;  1VDR A;  2ZZA A;  4X5I A;  2C2S A;  4XT6 A;  3NXR A;  4FHB A;  4Q6A A;  4QLE A;  4H96 A;  3ZPG A;  4DFR A;  2ANQ A;  3QL3 A;  4ECK A;  4KJJ A;  3FQZ A;  3DL6 A;  3OCH A;  1PD8 A;  4HA9 A;  1DYJ A;  3FQF A;  1RX3 A;  1RA2 A;  3INV A;  3IA4 A;  4H98 A;  5HI6 A;  1RX4 A;  4KJK A;  1DG8 A;  1DIS A;  2HQP A;  2ANO A;  4X5F A;  4ELG A;  2O7P A;  3FY9 X;  3JWM A;  4XRB A;  3GYF A;  5JA3 A;  5HVB A;  4QLG A;  2W3B A;  4KAK A;  2W3V A;  3IRN A;  1JOM A;  3NZC X;  1IA1 A;  1RF7 A;  2BLB A;  3FYV X;  4QI9 A;  3SH2 A;  3KJS A;  3SAI A;  4DDR A;  1RB2 A;  1DIU A;  3RO9 A;  3ZPC A;  3F91 A;  3QG2 A;  1DG7 A;  5HPB A;  5HSR A;  4LAG X;  4KM2 A;  2W9H A;  4ELB A;  4XE6 X;  3GI2 A;  2DHF A;  1RE7 A;  1DRE A;  2INQ A;  3FQO A;  5HSU A;  5CCC A;  3UM8 A;  3QLY A;  1MVT A;  3DG8 A;  3SQY X;  3K47 A;  1RB3 A;  4PDJ A;  4M6K A;  4PSY A;  1DYI A;  4LEK X;  1JOL A;  1OHJ A;  4KL9 A;  5FDA A;  2P4G A;  1DYR A;  1RX8 A;  3FY8 X;  7DFR A;  1S3W A;  1RX5 A;  5EAJ A;  5DFR A;  5JG0 X;  3M09 A;  1DDS A;  3IA5 A;  1U72 A;  2OBC A;  1KLK A;  4M7V A;  2H2Q A;  1S3U A;  1RX2 A;  3FYW X;  3E0B A;  1DR4 A;  4KLX A;  4Q67 A;  3VCO A;  3DFR A;  4PTH A;  4PTJ A;  1RA3 A;  3S9U A;  1DR3 A;  3FRA X;  3EEJ A;  1DYH A;  3SGY A;  4PST A;  5HF0 X;  3NZ6 X;  1MVS A;  4P66 A;  2LF1 A;  4IXF X;  1DDR A;  2OIP A;  1BOZ A;  4QJC A;  3SR5 X;  4LAH X;  3QLX A;  5ECC A;  2W3M A;  2W3A A;  1M79 A;  1U71 A;  1DR7 A;  4ELE A;  4FGH A;  4KY8 A;  3M08 A;  1DHI A;  3NXX A;  1IA4 A;  4XEC X;  3CSE A;  1TDR A;  4KM0 A;  3DGA A;  3NZB X;  4DPH A;  4HOF A;  3QLZ A;  3FRF X;  3DAU A;  2QK8 A;  2JYB A;  3FS6 A;  3IX9 A;  3JSU A;  2B3Z A;  2HXV A;  4G8Z X;  2L28 A;  3SRR X;  3FRB X;  2KGK A;  1RA8 A;  3KJR A;  3JTW A;  5DXV A;  3SA1 A;  3SA2 A;  3I3R A;  2D0K A;  6DFR A;  4RGC A;  4G3M A;  4HOE A;  1DRB A;  1DRH A;  3FRE X;  1DRF A;  1J3J A;  3HBB A;  4I1N A;  2ITH A;  3NXY A;  2CIG A;  1S3Y A;  5HT4 A;  4X5H A;  1RX6 A;  3FL8 A;  5HQY A;  1AI9 A;  3JWF A;  3CD2 A;  4P3Q A;  1LY3 A;  1DLR A;  1RA1 A;  3EIG A;  1KMV A;  3HJ3 A;  3UM6 A;  3EEK A;  1S3V A;  4ELF A;  2W3W A;  2W9G A;  3NXT A;  2HM9 A;  3K2H A;  3R33 A;  1RA9 A;  3D84 X;  1DF7 A;  4KNE A;  3L3R A;  1LY4 A;  4M7U A;  3QLR A;  2DRC A;  4Q0D A;  1RD7 A;  3NZD A;  4G95 A;  4XT4 A;  3CL9 A;  1JUV A;  1RC4 A;  5HUI A;  3S7A A;  3QL0 A;  4X5G A;  3QFX A;  3SRQ X;  4GH8 A;  3NRR A;  1CZ3 A;  1DLS A;  3NXO A;  3QLS A;  2GD9 A;  3JW5 A;  3RG9 A;  2BLC A;  3FQ0 A;  2W9T A;  2BLA A;  4FGG A;  1J3K A;  4KD7 A;  3LG4 A;  1DR6 A;  3GHW A;  3SRW X;  3N0H A;  4CD2 A;  1M78 A;  1IA3 A;  3QYO A;  3UM5 A;  5HF2 X;  2XW7 A;  1HFQ A;  4M6J A;  2C2T A;  3F0B X;  3SRU X;  2FZI A;  3CLB A;  4NX6 A;  4EIG A;  1CD2 A;  4QHV A;  4XT5 A;  3Q1H A;  3TQB A;  4XT7 A;  1DG5 A;  4ELH A;  1DR1 A;  3K45 A;  4X5J A;  1RG7 A;  1M7A A;  3F0X X;  1J3I A;  4QLF A;  1HFP A;  3S3V A;  3F8Z A;  8DFR A;  4KEB A;  5E8Q A;  2CD2 A;  3DAT A;  3EX8 A;  3F8Y A;  4OSG A;  3F0V X;  2D5N A;  3NU0 A;  4Q0E A;  3NZA X;  3NXV A;  1KMS A;  3QLW A;  1DR5 A;  4HA7 A;  1DHF A;  1RX7 A;  3DRC A;  1AO8 A;  4M6L A;  4M2X A;  3FRD X;  4OR7 A;  4DP3 A;  2AZN A;  5U26 A;  4H95 A;  3OAF A;  3TQA A;  3F0U X;  3JWK A;  3F0S X;  4PSS A;  1DRA A;  3IRO A;  3TD8 A;  4H97 A; 
#chains in the Genus database with same CATH topology
 3JW3 A;  4EJ1 A;  1YHO A;  3FQC A;  1PD9 A;  1ZDR A;  3EEM A;  3NZ9 X;  3DL5 A;  4KYA A;  1DHJ A;  2W9S A;  2G6V A;  5U27 A;  4KJL A;  4IXE D;  5HVE A;  4I13 A;  3KFY A;  1RH3 A;  3I8A X;  3IRM A;  3FQV A;  1AOE A;  1HFR A;  1OHK A;  1RX1 A;  3GHV A;  3TQ8 A;  3JWC A;  1RX9 A;  1LUD A;  1IA2 A;  2FZH A;  1SEJ A;  4TU5 X;  3K74 A;  4KFJ A;  4KY4 A;  3TQ9 A;  4LAE X;  1PDB A;  4IXG X;  3SRS X;  5HT5 A;  4XT8 A;  2BL9 A;  4DPD A;  4QJZ D;  3EEL A;  1E26 A;  3KY8 A;  4KBN A;  5HQZ A;  1QZF A;  3QYL A;  4P3R A;  3D80 A;  4EIL A;  3QGT A;  2FZJ A;  3JVX A;  3KGY A;  5CC9 A;  4NX7 A;  3F0Q X;  1DAJ A;  3GHC A;  5ECX A;  4P68 A;  3NTZ A;  1DR2 A;  1BZF A;  4HOG A;  1D1G A;  4EIZ A;  1VJ3 A;  3FL9 A;  3ROA A;  1U70 A;  1VDR A;  2ZZA A;  4X5I A;  2C2S A;  4XT6 A;  3NXR A;  4FHB A;  4Q6A A;  4QLE A;  4H96 A;  3ZPG A;  4DFR A;  2ANQ A;  3QL3 A;  4ECK A;  4KJJ A;  3FQZ A;  3DL6 A;  3OCH A;  1PD8 A;  4HA9 A;  1DYJ A;  3FQF A;  1RX3 A;  1RA2 A;  3INV A;  3IA4 A;  4H98 A;  5HI6 A;  1RX4 A;  4KJK A;  1DG8 A;  1DIS A;  2HQP A;  2ANO A;  4X5F A;  4ELG A;  2O7P A;  3FY9 X;  3JWM A;  4XRB A;  3GYF A;  5JA3 A;  5HVB A;  4QLG A;  2W3B A;  4KAK A;  2W3V A;  3IRN A;  1JOM A;  3NZC X;  1IA1 A;  1RF7 A;  2BLB A;  3FYV X;  4QI9 A;  3SH2 A;  3KJS A;  3SAI A;  4DDR A;  1RB2 A;  1DIU A;  3RO9 A;  3ZPC A;  3F91 A;  3QG2 A;  1DG7 A;  5HPB A;  5HSR A;  4LAG X;  4KM2 A;  2W9H A;  4ELB A;  4XE6 X;  3GI2 A;  2DHF A;  1RE7 A;  1DRE A;  2INQ A;  3FQO A;  5HSU A;  5CCC A;  3UM8 A;  3QLY A;  1MVT A;  3DG8 A;  3SQY X;  3K47 A;  1RB3 A;  4PDJ A;  4M6K A;  4PSY A;  1DYI A;  4LEK X;  1JOL A;  1OHJ A;  4KL9 A;  5FDA A;  2P4G A;  1DYR A;  1RX8 A;  3FY8 X;  7DFR A;  1S3W A;  1RX5 A;  5EAJ A;  5DFR A;  5JG0 X;  3M09 A;  1DDS A;  3IA5 A;  1U72 A;  2OBC A;  1KLK A;  4M7V A;  2H2Q A;  1S3U A;  1RX2 A;  3FYW X;  3E0B A;  1DR4 A;  4KLX A;  4Q67 A;  3VCO A;  3DFR A;  4PTH A;  4PTJ A;  1RA3 A;  3S9U A;  1DR3 A;  3FRA X;  3EEJ A;  1DYH A;  3SGY A;  4PST A;  5HF0 X;  3NZ6 X;  1MVS A;  4P66 A;  2LF1 A;  4IXF X;  1DDR A;  2OIP A;  1BOZ A;  4QJC A;  3SR5 X;  4LAH X;  3QLX A;  5ECC A;  2W3M A;  2W3A A;  1M79 A;  1U71 A;  1DR7 A;  4ELE A;  4FGH A;  4KY8 A;  3M08 A;  1DHI A;  3NXX A;  1IA4 A;  4XEC X;  3CSE A;  1TDR A;  4KM0 A;  3DGA A;  3NZB X;  4DPH A;  4HOF A;  3QLZ A;  3FRF X;  3DAU A;  2QK8 A;  2JYB A;  3FS6 A;  3IX9 A;  3JSU A;  2B3Z A;  2HXV A;  4G8Z X;  2L28 A;  3SRR X;  3FRB X;  2KGK A;  1RA8 A;  3KJR A;  3JTW A;  5DXV A;  3SA1 A;  3SA2 A;  3I3R A;  2D0K A;  6DFR A;  4RGC A;  4G3M A;  4HOE A;  1DRB A;  1DRH A;  3FRE X;  1DRF A;  1J3J A;  3HBB A;  4I1N A;  2ITH A;  3NXY A;  2CIG A;  1S3Y A;  5HT4 A;  4X5H A;  1RX6 A;  3FL8 A;  5HQY A;  1AI9 A;  3JWF A;  3CD2 A;  4P3Q A;  1LY3 A;  1DLR A;  1RA1 A;  3EIG A;  1KMV A;  3HJ3 A;  3UM6 A;  3EEK A;  1S3V A;  4ELF A;  2W3W A;  2W9G A;  3NXT A;  2HM9 A;  3K2H A;  3R33 A;  1RA9 A;  3D84 X;  1DF7 A;  4KNE A;  3L3R A;  1LY4 A;  4M7U A;  3QLR A;  2DRC A;  4Q0D A;  1RD7 A;  3NZD A;  4G95 A;  4XT4 A;  3CL9 A;  1JUV A;  1RC4 A;  5HUI A;  3S7A A;  3QL0 A;  4X5G A;  3QFX A;  3SRQ X;  4GH8 A;  3NRR A;  1CZ3 A;  1DLS A;  3NXO A;  3QLS A;  2GD9 A;  3JW5 A;  3RG9 A;  2BLC A;  3FQ0 A;  2W9T A;  2BLA A;  4FGG A;  1J3K A;  4KD7 A;  3LG4 A;  1DR6 A;  3GHW A;  3SRW X;  3N0H A;  4CD2 A;  1M78 A;  1IA3 A;  3QYO A;  3UM5 A;  5HF2 X;  2XW7 A;  1HFQ A;  4M6J A;  2C2T A;  3F0B X;  3SRU X;  2FZI A;  3CLB A;  4NX6 A;  4EIG A;  1CD2 A;  4QHV A;  4XT5 A;  3Q1H A;  3TQB A;  4XT7 A;  1DG5 A;  4ELH A;  1DR1 A;  3K45 A;  4X5J A;  1RG7 A;  1M7A A;  3F0X X;  1J3I A;  4QLF A;  1HFP A;  3S3V A;  3F8Z A;  8DFR A;  4KEB A;  5E8Q A;  2CD2 A;  3DAT A;  3EX8 A;  3F8Y A;  4OSG A;  3F0V X;  2D5N A;  3NU0 A;  4Q0E A;  3NZA X;  3NXV A;  1KMS A;  3QLW A;  1DR5 A;  4HA7 A;  1DHF A;  1RX7 A;  3DRC A;  1AO8 A;  4M6L A;  4M2X A;  3FRD X;  4OR7 A;  4DP3 A;  2AZN A;  5U26 A;  4H95 A;  3OAF A;  3TQA A;  3F0U X;  3JWK A;  3F0S X;  4PSS A;  1DRA A;  3IRO A;  3TD8 A;  4H97 A; 
#chains in the Genus database with same CATH homology
 3JW3 A;  4EJ1 A;  1YHO A;  3FQC A;  1PD9 A;  1ZDR A;  3EEM A;  3NZ9 X;  3DL5 A;  4KYA A;  1DHJ A;  2W9S A;  2G6V A;  5U27 A;  4KJL A;  4IXE D;  5HVE A;  4I13 A;  3KFY A;  1RH3 A;  3I8A X;  3IRM A;  3FQV A;  1AOE A;  1HFR A;  1OHK A;  1RX1 A;  3GHV A;  3TQ8 A;  3JWC A;  1RX9 A;  1LUD A;  1IA2 A;  2FZH A;  1SEJ A;  4TU5 X;  3K74 A;  4KFJ A;  4KY4 A;  3TQ9 A;  4LAE X;  1PDB A;  4IXG X;  3SRS X;  5HT5 A;  4XT8 A;  2BL9 A;  4DPD A;  4QJZ D;  3EEL A;  1E26 A;  3KY8 A;  4KBN A;  5HQZ A;  1QZF A;  3QYL A;  4P3R A;  3D80 A;  4EIL A;  3QGT A;  2FZJ A;  3JVX A;  3KGY A;  5CC9 A;  4NX7 A;  3F0Q X;  1DAJ A;  3GHC A;  5ECX A;  4P68 A;  3NTZ A;  1DR2 A;  1BZF A;  4HOG A;  1D1G A;  4EIZ A;  1VJ3 A;  3FL9 A;  3ROA A;  1U70 A;  1VDR A;  2ZZA A;  4X5I A;  2C2S A;  4XT6 A;  3NXR A;  4FHB A;  4Q6A A;  4QLE A;  4H96 A;  3ZPG A;  4DFR A;  2ANQ A;  3QL3 A;  4ECK A;  4KJJ A;  3FQZ A;  3DL6 A;  3OCH A;  1PD8 A;  4HA9 A;  1DYJ A;  3FQF A;  1RX3 A;  1RA2 A;  3INV A;  3IA4 A;  4H98 A;  5HI6 A;  1RX4 A;  4KJK A;  1DG8 A;  1DIS A;  2HQP A;  2ANO A;  4X5F A;  4ELG A;  2O7P A;  3FY9 X;  3JWM A;  4XRB A;  3GYF A;  5JA3 A;  5HVB A;  4QLG A;  2W3B A;  4KAK A;  2W3V A;  3IRN A;  1JOM A;  3NZC X;  1IA1 A;  1RF7 A;  2BLB A;  3FYV X;  4QI9 A;  3SH2 A;  3KJS A;  3SAI A;  4DDR A;  1RB2 A;  1DIU A;  3RO9 A;  3ZPC A;  3F91 A;  3QG2 A;  1DG7 A;  5HPB A;  5HSR A;  4LAG X;  4KM2 A;  2W9H A;  4ELB A;  4XE6 X;  3GI2 A;  2DHF A;  1RE7 A;  1DRE A;  2INQ A;  3FQO A;  5HSU A;  5CCC A;  3UM8 A;  3QLY A;  1MVT A;  3DG8 A;  3SQY X;  3K47 A;  1RB3 A;  4PDJ A;  4M6K A;  4PSY A;  1DYI A;  4LEK X;  1JOL A;  1OHJ A;  4KL9 A;  5FDA A;  2P4G A;  1DYR A;  1RX8 A;  3FY8 X;  7DFR A;  1S3W A;  1RX5 A;  5EAJ A;  5DFR A;  5JG0 X;  3M09 A;  1DDS A;  3IA5 A;  1U72 A;  2OBC A;  1KLK A;  4M7V A;  2H2Q A;  1S3U A;  1RX2 A;  3FYW X;  3E0B A;  1DR4 A;  4KLX A;  4Q67 A;  3VCO A;  3DFR A;  4PTH A;  4PTJ A;  1RA3 A;  3S9U A;  1DR3 A;  3FRA X;  3EEJ A;  1DYH A;  3SGY A;  4PST A;  5HF0 X;  3NZ6 X;  1MVS A;  4P66 A;  2LF1 A;  4IXF X;  1DDR A;  2OIP A;  1BOZ A;  4QJC A;  3SR5 X;  4LAH X;  3QLX A;  5ECC A;  2W3M A;  2W3A A;  1M79 A;  1U71 A;  1DR7 A;  4ELE A;  4FGH A;  4KY8 A;  3M08 A;  1DHI A;  3NXX A;  1IA4 A;  4XEC X;  3CSE A;  1TDR A;  4KM0 A;  3DGA A;  3NZB X;  4DPH A;  4HOF A;  3QLZ A;  3FRF X;  3DAU A;  2QK8 A;  2JYB A;  3FS6 A;  3IX9 A;  3JSU A;  2B3Z A;  2HXV A;  4G8Z X;  2L28 A;  3SRR X;  3FRB X;  2KGK A;  1RA8 A;  3KJR A;  3JTW A;  5DXV A;  3SA1 A;  3SA2 A;  3I3R A;  2D0K A;  6DFR A;  4RGC A;  4G3M A;  4HOE A;  1DRB A;  1DRH A;  3FRE X;  1DRF A;  1J3J A;  3HBB A;  4I1N A;  2ITH A;  3NXY A;  2CIG A;  1S3Y A;  5HT4 A;  4X5H A;  1RX6 A;  3FL8 A;  5HQY A;  1AI9 A;  3JWF A;  3CD2 A;  4P3Q A;  1LY3 A;  1DLR A;  1RA1 A;  3EIG A;  1KMV A;  3HJ3 A;  3UM6 A;  3EEK A;  1S3V A;  4ELF A;  2W3W A;  2W9G A;  3NXT A;  2HM9 A;  3K2H A;  3R33 A;  1RA9 A;  3D84 X;  1DF7 A;  4KNE A;  3L3R A;  1LY4 A;  4M7U A;  3QLR A;  2DRC A;  4Q0D A;  1RD7 A;  3NZD A;  4G95 A;  4XT4 A;  3CL9 A;  1JUV A;  1RC4 A;  5HUI A;  3S7A A;  3QL0 A;  4X5G A;  3QFX A;  3SRQ X;  4GH8 A;  3NRR A;  1CZ3 A;  1DLS A;  3NXO A;  3QLS A;  2GD9 A;  3JW5 A;  3RG9 A;  2BLC A;  3FQ0 A;  2W9T A;  2BLA A;  4FGG A;  1J3K A;  4KD7 A;  3LG4 A;  1DR6 A;  3GHW A;  3SRW X;  3N0H A;  4CD2 A;  1M78 A;  1IA3 A;  3QYO A;  3UM5 A;  5HF2 X;  2XW7 A;  1HFQ A;  4M6J A;  2C2T A;  3F0B X;  3SRU X;  2FZI A;  3CLB A;  4NX6 A;  4EIG A;  1CD2 A;  4QHV A;  4XT5 A;  3Q1H A;  3TQB A;  4XT7 A;  1DG5 A;  4ELH A;  1DR1 A;  3K45 A;  4X5J A;  1RG7 A;  1M7A A;  3F0X X;  1J3I A;  4QLF A;  1HFP A;  3S3V A;  3F8Z A;  8DFR A;  4KEB A;  5E8Q A;  2CD2 A;  3DAT A;  3EX8 A;  3F8Y A;  4OSG A;  3F0V X;  2D5N A;  3NU0 A;  4Q0E A;  3NZA X;  3NXV A;  1KMS A;  3QLW A;  1DR5 A;  4HA7 A;  1DHF A;  1RX7 A;  3DRC A;  1AO8 A;  4M6L A;  4M2X A;  3FRD X;  4OR7 A;  4DP3 A;  2AZN A;  5U26 A;  4H95 A;  3OAF A;  3TQA A;  3F0U X;  3JWK A;  3F0S X;  4PSS A;  1DRA A;  3IRO A;  3TD8 A;  4H97 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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