1J3KA

Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with wr99210, nadph, and dump
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
231
structure length
221
Chain Sequence
MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCISLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETKKLQNVVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFILGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into antifolate resistance from malarial DHFR-TS structures.
pubmed doi rcsb
molecule tags Oxidoreductase, transferase
source organism Plasmodium falciparum
molecule keywords Bifunctional dihydrofolate reductase-thymidylate synthase
total genus 61
structure length 221
sequence length 231
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2003-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1j3kA00
3N0HA 4HOGA 3IRMA 3HJ3A 3JW5A 1DR5A 3FL9A 3NXRA 3RG9A 7DFRA 1DYHA 3JWCA 3NZCX 5HF2X 3QLRA 4EJ1A 4NX6A 2OBCA 2CD2A 1ZDRA 3JTWA 3NZ6X 3EX8A 3DATA 4FGGA 1RX5A 4PTHA 4DP3A 4G95A 2DRCA 4P3RA 4XT4A 3SA1A 3SA2A 4QJCA 4CD2A 2OIPA 3IA5A 3DRCA 3NZAX 2BL9A 1RE7A 1DYIA 1J3KA 4KJKA 2D0KA 1RB3A 1U70A 5HSRA 3UM6A 3E0BA 4KY8A 3SH2A 4ECKA 2C2SA 5ECXA 1RB2A 2W3WA 4KLXA 1DHJA 4M2XA 4X5GA 1DG8A 1RX7A 2W9TA 4H97A 3VCOA 4KD7A 1RC4A 1DRAA 3FY8X 3NXXA 2KGKA 4XRBA 4KEBA 3FYWX 1DR1A 3FQCA 3QL0A 1IA2A 1QZFA 2W3VA 3CLBA 3I8AX 1DHIA 5HQZA 4FHBA 3DL5A 3QG2A 1DDSA 4LAEX 2FZIA 4P66A 1RX2A 3NTZA 1DISA 2ZZAA 1M7AA 3EEMA 3NXOA 1JOLA 3F0VX 3M09A 2H2QA 2W9SA 4M6KA 1RA2A 4PSYA 3K2HA 4Q67A 4XT6A 4DPHA 2FZJA 1PDBA 1DR6A 1DIUA 2ITHA 2INQA 5HF0X 4Q6AA 3OAFA 5DFRA 2B3ZA 5CC9A 3QLXA 3KJSA 1J3IA 3FQZA 3NU0A 3UM5A 1BZFA 2ANOA 5JA3A 2C2TA 1DRHA 3GHCA 2W3MA 3NZBX 4KY4A 4Q0DA 4KJLA 3FREX 4M6JA 3SQYX 3F0BX 3FS6A 2G6VA 1RF7A 4NX7A 4EILA 2D5NA 3S9UA 1AOEA 2QK8A 1HFRA 3SR5X 3K74A 3CSEA 4QJZD 3F0XX 3FYVX 1S3VA 3QLWA 2BLBA 3TQ8A 3D84X 1U72A 3NXTA 3DL6A 3NZ9X 4PTJA 3DGAA 3QYOA 4OR7A 3JWMA 4TU5X 1RX9A 4KFJA 1IA4A 3NRRA 5E8QA 3CL9A 2W9GA 4KL9A 1AI9A 4ELHA 1HFPA 3SRRX 3TQAA 1TDRA 1KMSA 5HT5A 4HOEA 2O7PA 3JW3A 4EIGA 4KM0A 1RA1A 4KYAA 4QHVA 3F91A 1JOMA 1DG7A 3Q1HA 3L3RA 4I1NA 3KFYA 3HBBA 4KNEA 3FRDX 4I13A 4XE6X 1D1GA 5DXVA 4IXED 2BLAA 3S3VA 3JSUA 4PDJA 4P3QA 3OCHA 3EIGA 1DHFA 3F0UX 4RGCA 1DLSA 3QL3A 3DG8A 1RX1A 4QLFA 1KMVA 2W9HA 1DR4A 3TQBA 1RA3A 2FZHA 4LEKX 4IXFX 3RO9A 4EIZA 5HVEA 3IX9A 3FY9X 3QYLA 1DREA 5HVBA 4X5FA 1MVSA 4KAKA 3K47A 3UM8A 1DF7A 1IA1A 5HQYA 5CCCA 4LAGX 4GH8A 4HA9A 4LAHX 1AO8A 3GHWA 3NXVA 3GHVA 1DDRA 1IA3A 3QGTA 3JWKA 1LY4A 1S3UA 1DYJA 3FQFA 3CD2A 3NXYA 2CIGA 3FRFX 3QFXA 4IXGX 5HSUA 3ROAA 3S7AA 3SRSX 4FGHA 2L28A 1SEJA 4KM2A 3EELA 2ANQA 1DR2A 3SRUX 3FQ0A 4M7VA 3EEJA 3NZDA 3TQ9A 3DAUA 6DFRA 1E26A 1CZ3A 1JUVA 1RA9A 3QLSA 3JWFA 1HFQA 1MVTA 3F0QX 2HM9A 3INVA 1CD2A 5EAJA 2JYBA 4XT7A 1DLRA 3FQOA 1DR3A 4H96A 4G3MA 1BOZA 2DHFA 5ECCA 3D80A 3GI2A 3SRWX 2LF1A 3IRNA 4KBNA 2XW7A 1VDRA 3SRQX 4PSTA 1OHJA 3FRAX 1DRBA 1S3WA 3SGYA 3K45A 3QLZA 5HPBA 3ZPGA 2W3AA 1S3YA 4HOFA 1RH3A 3KY8A 3IROA 4PSSA 3R33A 8DFRA 1RX6A 1RD7A 3KJRA 4DPDA 4DFRA 1M78A 3FQVA 5JG0X 1RX3A 1YHOA 1DRFA 2HQPA 3LG4A 3EEKA 1KLKA 1DR7A 3F0SX 3F8ZA 4X5IA 1DYRA 1DAJA 4Q0EA 4H98A 3KGYA 3M08A 1RG7A 1J3JA 1PD9A 3I3RA 3FRBX 1LUDA 1RX4A 3IA4A 4OSGA 1U71A 4P68A 4M7UA 4ELEA 4XECX 1PD8A 4M6LA 5U26A 3F8YA 3DFRA 4H95A 4ELBA 1RX8A 2HXVA 5HUIA 3FL8A 3ZPCA 1DG5A 1LY3A 2P4GA 3TD8A 1OHKA 4QLGA 4QLEA 4X5JA 5FDAA 1VJ3A 4X5HA 3JVXA 1RA8A 4ELGA 3GYFA 4XT8A 5HI6A 1M79A 5U27A 5HT4A 4ELFA 4DDRA 2BLCA 2AZNA 4KJJA 3SAIA 2GD9A 4G8ZX 2W3BA 3QLYA 4XT5A 4QI9A 4HA7A
chains in the Genus database with same CATH superfamily
3N0HA 4HOGA 3IRMA 3HJ3A 3JW5A 1DR5A 3FL9A 3NXRA 3RG9A 7DFRA 1DYHA 3JWCA 3NZCX 5HF2X 3QLRA 4EJ1A 4NX6A 2OBCA 2CD2A 1ZDRA 3JTWA 3NZ6X 3EX8A 3DATA 4FGGA 1RX5A 4PTHA 4DP3A 4G95A 2DRCA 4P3RA 4XT4A 3SA1A 3SA2A 4QJCA 4CD2A 2OIPA 3IA5A 3DRCA 3NZAX 2BL9A 1RE7A 1DYIA 1J3KA 4KJKA 2D0KA 1RB3A 1U70A 5HSRA 3UM6A 3E0BA 4KY8A 3SH2A 4ECKA 2C2SA 5ECXA 1RB2A 2W3WA 4KLXA 1DHJA 4M2XA 4X5GA 1DG8A 1RX7A 2W9TA 4H97A 3VCOA 4KD7A 1RC4A 1DRAA 3FY8X 3NXXA 2KGKA 4XRBA 4KEBA 3FYWX 1DR1A 3FQCA 3QL0A 1IA2A 1QZFA 2W3VA 3CLBA 3I8AX 1DHIA 5HQZA 4FHBA 3DL5A 3QG2A 1DDSA 4LAEX 2FZIA 4P66A 1RX2A 3NTZA 1DISA 2ZZAA 1M7AA 3EEMA 3NXOA 1JOLA 3F0VX 3M09A 2H2QA 2W9SA 4M6KA 1RA2A 4PSYA 3K2HA 4Q67A 4XT6A 4DPHA 2FZJA 1PDBA 1DR6A 1DIUA 2ITHA 2INQA 5HF0X 4Q6AA 3OAFA 5DFRA 2B3ZA 5CC9A 3QLXA 3KJSA 1J3IA 3FQZA 3NU0A 3UM5A 1BZFA 2ANOA 5JA3A 2C2TA 1DRHA 3GHCA 2W3MA 3NZBX 4KY4A 4Q0DA 4KJLA 3FREX 4M6JA 3SQYX 3F0BX 3FS6A 2G6VA 1RF7A 4NX7A 4EILA 2D5NA 3S9UA 1AOEA 2QK8A 1HFRA 3SR5X 3K74A 3CSEA 4QJZD 3F0XX 3FYVX 1S3VA 3QLWA 2BLBA 3TQ8A 3D84X 1U72A 3NXTA 3DL6A 3NZ9X 4PTJA 3DGAA 3QYOA 4OR7A 3JWMA 4TU5X 1RX9A 4KFJA 1IA4A 3NRRA 5E8QA 3CL9A 2W9GA 4KL9A 1AI9A 4ELHA 1HFPA 3SRRX 3TQAA 1TDRA 1KMSA 5HT5A 4HOEA 2O7PA 3JW3A 4EIGA 4KM0A 1RA1A 4KYAA 4QHVA 3F91A 1JOMA 1DG7A 3Q1HA 3L3RA 4I1NA 3KFYA 3HBBA 4KNEA 3FRDX 4I13A 4XE6X 1D1GA 5DXVA 4IXED 2BLAA 3S3VA 3JSUA 4PDJA 4P3QA 3OCHA 3EIGA 1DHFA 3F0UX 4RGCA 1DLSA 3QL3A 3DG8A 1RX1A 4QLFA 1KMVA 2W9HA 1DR4A 3TQBA 1RA3A 2FZHA 4LEKX 4IXFX 3RO9A 4EIZA 5HVEA 3IX9A 3FY9X 3QYLA 1DREA 5HVBA 4X5FA 1MVSA 4KAKA 3K47A 3UM8A 1DF7A 1IA1A 5HQYA 5CCCA 4LAGX 4GH8A 4HA9A 4LAHX 1AO8A 3GHWA 3NXVA 3GHVA 1DDRA 1IA3A 3QGTA 3JWKA 1LY4A 1S3UA 1DYJA 3FQFA 3CD2A 3NXYA 2CIGA 3FRFX 3QFXA 4IXGX 5HSUA 3ROAA 3S7AA 3SRSX 4FGHA 2L28A 1SEJA 4KM2A 3EELA 2ANQA 1DR2A 3SRUX 3FQ0A 4M7VA 3EEJA 3NZDA 3TQ9A 3DAUA 6DFRA 1E26A 1CZ3A 1JUVA 1RA9A 3QLSA 3JWFA 1HFQA 1MVTA 3F0QX 2HM9A 3INVA 1CD2A 5EAJA 2JYBA 4XT7A 1DLRA 3FQOA 1DR3A 4H96A 4G3MA 1BOZA 2DHFA 5ECCA 3D80A 3GI2A 3SRWX 2LF1A 3IRNA 4KBNA 2XW7A 1VDRA 3SRQX 4PSTA 1OHJA 3FRAX 1DRBA 1S3WA 3SGYA 3K45A 3QLZA 5HPBA 3ZPGA 2W3AA 1S3YA 4HOFA 1RH3A 3KY8A 3IROA 4PSSA 3R33A 8DFRA 1RX6A 1RD7A 3KJRA 4DPDA 4DFRA 1M78A 3FQVA 5JG0X 1RX3A 1YHOA 1DRFA 2HQPA 3LG4A 3EEKA 1KLKA 1DR7A 3F0SX 3F8ZA 4X5IA 1DYRA 1DAJA 4Q0EA 4H98A 3KGYA 3M08A 1RG7A 1J3JA 1PD9A 3I3RA 3FRBX 1LUDA 1RX4A 3IA4A 4OSGA 1U71A 4P68A 4M7UA 4ELEA 4XECX 1PD8A 4M6LA 5U26A 3F8YA 3DFRA 4H95A 4ELBA 1RX8A 2HXVA 5HUIA 3FL8A 3ZPCA 1DG5A 1LY3A 2P4GA 3TD8A 1OHKA 4QLGA 4QLEA 4X5JA 5FDAA 1VJ3A 4X5HA 3JVXA 1RA8A 4ELGA 3GYFA 4XT8A 5HI6A 1M79A 5U27A 5HT4A 4ELFA 4DDRA 2BLCA 2AZNA 4KJJA 3SAIA 2GD9A 4G8ZX 2W3BA 3QLYA 4XT5A 4QI9A 4HA7A
chains in the Genus database with same CATH topology
3N0HA 4HOGA 3IRMA 3HJ3A 3JW5A 1DR5A 3FL9A 3NXRA 3RG9A 7DFRA 1DYHA 3JWCA 3NZCX 5HF2X 3QLRA 4EJ1A 4NX6A 2OBCA 2CD2A 1ZDRA 3JTWA 3NZ6X 3EX8A 3DATA 4FGGA 1RX5A 4PTHA 4DP3A 4G95A 2DRCA 4P3RA 4XT4A 3SA1A 3SA2A 4QJCA 4CD2A 2OIPA 3IA5A 3DRCA 3NZAX 2BL9A 1RE7A 1DYIA 1J3KA 4KJKA 2D0KA 1RB3A 1U70A 5HSRA 3UM6A 3E0BA 4KY8A 3SH2A 4ECKA 2C2SA 5ECXA 1RB2A 2W3WA 4KLXA 1DHJA 4M2XA 4X5GA 1DG8A 1RX7A 2W9TA 4H97A 3VCOA 4KD7A 1RC4A 1DRAA 3FY8X 3NXXA 2KGKA 4XRBA 4KEBA 3FYWX 1DR1A 3FQCA 3QL0A 1IA2A 1QZFA 2W3VA 3CLBA 3I8AX 1DHIA 5HQZA 4FHBA 3DL5A 3QG2A 1DDSA 4LAEX 2FZIA 4P66A 1RX2A 3NTZA 1DISA 2ZZAA 1M7AA 3EEMA 3NXOA 1JOLA 3F0VX 3M09A 2H2QA 2W9SA 4M6KA 1RA2A 4PSYA 3K2HA 4Q67A 4XT6A 4DPHA 2FZJA 1PDBA 1DR6A 1DIUA 2ITHA 2INQA 5HF0X 4Q6AA 3OAFA 5DFRA 2B3ZA 5CC9A 3QLXA 3KJSA 1J3IA 3FQZA 3NU0A 3UM5A 1BZFA 2ANOA 5JA3A 2C2TA 1DRHA 3GHCA 2W3MA 3NZBX 4KY4A 4Q0DA 4KJLA 3FREX 4M6JA 3SQYX 3F0BX 3FS6A 2G6VA 1RF7A 4NX7A 4EILA 2D5NA 3S9UA 1AOEA 2QK8A 1HFRA 3SR5X 3K74A 3CSEA 4QJZD 3F0XX 3FYVX 1S3VA 3QLWA 2BLBA 3TQ8A 3D84X 1U72A 3NXTA 3DL6A 3NZ9X 4PTJA 3DGAA 3QYOA 4OR7A 3JWMA 4TU5X 1RX9A 4KFJA 1IA4A 3NRRA 5E8QA 3CL9A 2W9GA 4KL9A 1AI9A 4ELHA 1HFPA 3SRRX 3TQAA 1TDRA 1KMSA 5HT5A 4HOEA 2O7PA 3JW3A 4EIGA 4KM0A 1RA1A 4KYAA 4QHVA 3F91A 1JOMA 1DG7A 3Q1HA 3L3RA 4I1NA 3KFYA 3HBBA 4KNEA 3FRDX 4I13A 4XE6X 1D1GA 5DXVA 4IXED 2BLAA 3S3VA 3JSUA 4PDJA 4P3QA 3OCHA 3EIGA 1DHFA 3F0UX 4RGCA 1DLSA 3QL3A 3DG8A 1RX1A 4QLFA 1KMVA 2W9HA 1DR4A 3TQBA 1RA3A 2FZHA 4LEKX 4IXFX 3RO9A 4EIZA 5HVEA 3IX9A 3FY9X 3QYLA 1DREA 5HVBA 4X5FA 1MVSA 4KAKA 3K47A 3UM8A 1DF7A 1IA1A 5HQYA 5CCCA 4LAGX 4GH8A 4HA9A 4LAHX 1AO8A 3GHWA 3NXVA 3GHVA 1DDRA 1IA3A 3QGTA 3JWKA 1LY4A 1S3UA 1DYJA 3FQFA 3CD2A 3NXYA 2CIGA 3FRFX 3QFXA 4IXGX 5HSUA 3ROAA 3S7AA 3SRSX 4FGHA 2L28A 1SEJA 4KM2A 3EELA 2ANQA 1DR2A 3SRUX 3FQ0A 4M7VA 3EEJA 3NZDA 3TQ9A 3DAUA 6DFRA 1E26A 1CZ3A 1JUVA 1RA9A 3QLSA 3JWFA 1HFQA 1MVTA 3F0QX 2HM9A 3INVA 1CD2A 5EAJA 2JYBA 4XT7A 1DLRA 3FQOA 1DR3A 4H96A 4G3MA 1BOZA 2DHFA 5ECCA 3D80A 3GI2A 3SRWX 2LF1A 3IRNA 4KBNA 2XW7A 1VDRA 3SRQX 4PSTA 1OHJA 3FRAX 1DRBA 1S3WA 3SGYA 3K45A 3QLZA 5HPBA 3ZPGA 2W3AA 1S3YA 4HOFA 1RH3A 3KY8A 3IROA 4PSSA 3R33A 8DFRA 1RX6A 1RD7A 3KJRA 4DPDA 4DFRA 1M78A 3FQVA 5JG0X 1RX3A 1YHOA 1DRFA 2HQPA 3LG4A 3EEKA 1KLKA 1DR7A 3F0SX 3F8ZA 4X5IA 1DYRA 1DAJA 4Q0EA 4H98A 3KGYA 3M08A 1RG7A 1J3JA 1PD9A 3I3RA 3FRBX 1LUDA 1RX4A 3IA4A 4OSGA 1U71A 4P68A 4M7UA 4ELEA 4XECX 1PD8A 4M6LA 5U26A 3F8YA 3DFRA 4H95A 4ELBA 1RX8A 2HXVA 5HUIA 3FL8A 3ZPCA 1DG5A 1LY3A 2P4GA 3TD8A 1OHKA 4QLGA 4QLEA 4X5JA 5FDAA 1VJ3A 4X5HA 3JVXA 1RA8A 4ELGA 3GYFA 4XT8A 5HI6A 1M79A 5U27A 5HT4A 4ELFA 4DDRA 2BLCA 2AZNA 4KJJA 3SAIA 2GD9A 4G8ZX 2W3BA 3QLYA 4XT5A 4QI9A 4HA7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3N0H A;  4HOG A;  3IRM A;  3HJ3 A;  3JW5 A;  1DR5 A;  3FL9 A;  3NXR A;  3RG9 A;  7DFR A;  1DYH A;  3JWC A;  3NZC X;  5HF2 X;  3QLR A;  4EJ1 A;  4NX6 A;  2OBC A;  2CD2 A;  1ZDR A;  3JTW A;  3NZ6 X;  3EX8 A;  3DAT A;  4FGG A;  1RX5 A;  4PTH A;  4DP3 A;  4G95 A;  2DRC A;  4P3R A;  4XT4 A;  3SA1 A;  3SA2 A;  4QJC A;  4CD2 A;  2OIP A;  3IA5 A;  3DRC A;  3NZA X;  2BL9 A;  1RE7 A;  1DYI A;  1J3K A;  4KJK A;  2D0K A;  1RB3 A;  1U70 A;  5HSR A;  3UM6 A;  3E0B A;  4KY8 A;  3SH2 A;  4ECK A;  2C2S A;  5ECX A;  1RB2 A;  2W3W A;  4KLX A;  1DHJ A;  4M2X A;  4X5G A;  1DG8 A;  1RX7 A;  2W9T A;  4H97 A;  3VCO A;  4KD7 A;  1RC4 A;  1DRA A;  3FY8 X;  3NXX A;  2KGK A;  4XRB A;  4KEB A;  3FYW X;  1DR1 A;  3FQC A;  3QL0 A;  1IA2 A;  1QZF A;  2W3V A;  3CLB A;  3I8A X;  1DHI A;  5HQZ A;  4FHB A;  3DL5 A;  3QG2 A;  1DDS A;  4LAE X;  2FZI A;  4P66 A;  1RX2 A;  3NTZ A;  1DIS A;  2ZZA A;  1M7A A;  3EEM A;  3NXO A;  1JOL A;  3F0V X;  3M09 A;  2H2Q A;  2W9S A;  4M6K A;  1RA2 A;  4PSY A;  3K2H A;  4Q67 A;  4XT6 A;  4DPH A;  2FZJ A;  1PDB A;  1DR6 A;  1DIU A;  2ITH A;  2INQ A;  5HF0 X;  4Q6A A;  3OAF A;  5DFR A;  2B3Z A;  5CC9 A;  3QLX A;  3KJS A;  1J3I A;  3FQZ A;  3NU0 A;  3UM5 A;  1BZF A;  2ANO A;  5JA3 A;  2C2T A;  1DRH A;  3GHC A;  2W3M A;  3NZB X;  4KY4 A;  4Q0D A;  4KJL A;  3FRE X;  4M6J A;  3SQY X;  3F0B X;  3FS6 A;  2G6V A;  1RF7 A;  4NX7 A;  4EIL A;  2D5N A;  3S9U A;  1AOE A;  2QK8 A;  1HFR A;  3SR5 X;  3K74 A;  3CSE A;  4QJZ D;  3F0X X;  3FYV X;  1S3V A;  3QLW A;  2BLB A;  3TQ8 A;  3D84 X;  1U72 A;  3NXT A;  3DL6 A;  3NZ9 X;  4PTJ A;  3DGA A;  3QYO A;  4OR7 A;  3JWM A;  4TU5 X;  1RX9 A;  4KFJ A;  1IA4 A;  3NRR A;  5E8Q A;  3CL9 A;  2W9G A;  4KL9 A;  1AI9 A;  4ELH A;  1HFP A;  3SRR X;  3TQA A;  1TDR A;  1KMS A;  5HT5 A;  4HOE A;  2O7P A;  3JW3 A;  4EIG A;  4KM0 A;  1RA1 A;  4KYA A;  4QHV A;  3F91 A;  1JOM A;  1DG7 A;  3Q1H A;  3L3R A;  4I1N A;  3KFY A;  3HBB A;  4KNE A;  3FRD X;  4I13 A;  4XE6 X;  1D1G A;  5DXV A;  4IXE D;  2BLA A;  3S3V A;  3JSU A;  4PDJ A;  4P3Q A;  3OCH A;  3EIG A;  1DHF A;  3F0U X;  4RGC A;  1DLS A;  3QL3 A;  3DG8 A;  1RX1 A;  4QLF A;  1KMV A;  2W9H A;  1DR4 A;  3TQB A;  1RA3 A;  2FZH A;  4LEK X;  4IXF X;  3RO9 A;  4EIZ A;  5HVE A;  3IX9 A;  3FY9 X;  3QYL A;  1DRE A;  5HVB A;  4X5F A;  1MVS A;  4KAK A;  3K47 A;  3UM8 A;  1DF7 A;  1IA1 A;  5HQY A;  5CCC A;  4LAG X;  4GH8 A;  4HA9 A;  4LAH X;  1AO8 A;  3GHW A;  3NXV A;  3GHV A;  1DDR A;  1IA3 A;  3QGT A;  3JWK A;  1LY4 A;  1S3U A;  1DYJ A;  3FQF A;  3CD2 A;  3NXY A;  2CIG A;  3FRF X;  3QFX A;  4IXG X;  5HSU A;  3ROA A;  3S7A A;  3SRS X;  4FGH A;  2L28 A;  1SEJ A;  4KM2 A;  3EEL A;  2ANQ A;  1DR2 A;  3SRU X;  3FQ0 A;  4M7V A;  3EEJ A;  3NZD A;  3TQ9 A;  3DAU A;  6DFR A;  1E26 A;  1CZ3 A;  1JUV A;  1RA9 A;  3QLS A;  3JWF A;  1HFQ A;  1MVT A;  3F0Q X;  2HM9 A;  3INV A;  1CD2 A;  5EAJ A;  2JYB A;  4XT7 A;  1DLR A;  3FQO A;  1DR3 A;  4H96 A;  4G3M A;  1BOZ A;  2DHF A;  5ECC A;  3D80 A;  3GI2 A;  3SRW X;  2LF1 A;  3IRN A;  4KBN A;  2XW7 A;  1VDR A;  3SRQ X;  4PST A;  1OHJ A;  3FRA X;  1DRB A;  1S3W A;  3SGY A;  3K45 A;  3QLZ A;  5HPB A;  3ZPG A;  2W3A A;  1S3Y A;  4HOF A;  1RH3 A;  3KY8 A;  3IRO A;  4PSS A;  3R33 A;  8DFR A;  1RX6 A;  1RD7 A;  3KJR A;  4DPD A;  4DFR A;  1M78 A;  3FQV A;  5JG0 X;  1RX3 A;  1YHO A;  1DRF A;  2HQP A;  3LG4 A;  3EEK A;  1KLK A;  1DR7 A;  3F0S X;  3F8Z A;  4X5I A;  1DYR A;  1DAJ A;  4Q0E A;  4H98 A;  3KGY A;  3M08 A;  1RG7 A;  1J3J A;  1PD9 A;  3I3R A;  3FRB X;  1LUD A;  1RX4 A;  3IA4 A;  4OSG A;  1U71 A;  4P68 A;  4M7U A;  4ELE A;  4XEC X;  1PD8 A;  4M6L A;  5U26 A;  3F8Y A;  3DFR A;  4H95 A;  4ELB A;  1RX8 A;  2HXV A;  5HUI A;  3FL8 A;  3ZPC A;  1DG5 A;  1LY3 A;  2P4G A;  3TD8 A;  1OHK A;  4QLG A;  4QLE A;  4X5J A;  5FDA A;  1VJ3 A;  4X5H A;  3JVX A;  1RA8 A;  4ELG A;  3GYF A;  4XT8 A;  5HI6 A;  1M79 A;  5U27 A;  5HT4 A;  4ELF A;  4DDR A;  2BLC A;  2AZN A;  4KJJ A;  3SAI A;  2GD9 A;  4G8Z X;  2W3B A;  3QLY A;  4XT5 A;  4QI9 A;  4HA7 A; 
#chains in the Genus database with same CATH topology
 3N0H A;  4HOG A;  3IRM A;  3HJ3 A;  3JW5 A;  1DR5 A;  3FL9 A;  3NXR A;  3RG9 A;  7DFR A;  1DYH A;  3JWC A;  3NZC X;  5HF2 X;  3QLR A;  4EJ1 A;  4NX6 A;  2OBC A;  2CD2 A;  1ZDR A;  3JTW A;  3NZ6 X;  3EX8 A;  3DAT A;  4FGG A;  1RX5 A;  4PTH A;  4DP3 A;  4G95 A;  2DRC A;  4P3R A;  4XT4 A;  3SA1 A;  3SA2 A;  4QJC A;  4CD2 A;  2OIP A;  3IA5 A;  3DRC A;  3NZA X;  2BL9 A;  1RE7 A;  1DYI A;  1J3K A;  4KJK A;  2D0K A;  1RB3 A;  1U70 A;  5HSR A;  3UM6 A;  3E0B A;  4KY8 A;  3SH2 A;  4ECK A;  2C2S A;  5ECX A;  1RB2 A;  2W3W A;  4KLX A;  1DHJ A;  4M2X A;  4X5G A;  1DG8 A;  1RX7 A;  2W9T A;  4H97 A;  3VCO A;  4KD7 A;  1RC4 A;  1DRA A;  3FY8 X;  3NXX A;  2KGK A;  4XRB A;  4KEB A;  3FYW X;  1DR1 A;  3FQC A;  3QL0 A;  1IA2 A;  1QZF A;  2W3V A;  3CLB A;  3I8A X;  1DHI A;  5HQZ A;  4FHB A;  3DL5 A;  3QG2 A;  1DDS A;  4LAE X;  2FZI A;  4P66 A;  1RX2 A;  3NTZ A;  1DIS A;  2ZZA A;  1M7A A;  3EEM A;  3NXO A;  1JOL A;  3F0V X;  3M09 A;  2H2Q A;  2W9S A;  4M6K A;  1RA2 A;  4PSY A;  3K2H A;  4Q67 A;  4XT6 A;  4DPH A;  2FZJ A;  1PDB A;  1DR6 A;  1DIU A;  2ITH A;  2INQ A;  5HF0 X;  4Q6A A;  3OAF A;  5DFR A;  2B3Z A;  5CC9 A;  3QLX A;  3KJS A;  1J3I A;  3FQZ A;  3NU0 A;  3UM5 A;  1BZF A;  2ANO A;  5JA3 A;  2C2T A;  1DRH A;  3GHC A;  2W3M A;  3NZB X;  4KY4 A;  4Q0D A;  4KJL A;  3FRE X;  4M6J A;  3SQY X;  3F0B X;  3FS6 A;  2G6V A;  1RF7 A;  4NX7 A;  4EIL A;  2D5N A;  3S9U A;  1AOE A;  2QK8 A;  1HFR A;  3SR5 X;  3K74 A;  3CSE A;  4QJZ D;  3F0X X;  3FYV X;  1S3V A;  3QLW A;  2BLB A;  3TQ8 A;  3D84 X;  1U72 A;  3NXT A;  3DL6 A;  3NZ9 X;  4PTJ A;  3DGA A;  3QYO A;  4OR7 A;  3JWM A;  4TU5 X;  1RX9 A;  4KFJ A;  1IA4 A;  3NRR A;  5E8Q A;  3CL9 A;  2W9G A;  4KL9 A;  1AI9 A;  4ELH A;  1HFP A;  3SRR X;  3TQA A;  1TDR A;  1KMS A;  5HT5 A;  4HOE A;  2O7P A;  3JW3 A;  4EIG A;  4KM0 A;  1RA1 A;  4KYA A;  4QHV A;  3F91 A;  1JOM A;  1DG7 A;  3Q1H A;  3L3R A;  4I1N A;  3KFY A;  3HBB A;  4KNE A;  3FRD X;  4I13 A;  4XE6 X;  1D1G A;  5DXV A;  4IXE D;  2BLA A;  3S3V A;  3JSU A;  4PDJ A;  4P3Q A;  3OCH A;  3EIG A;  1DHF A;  3F0U X;  4RGC A;  1DLS A;  3QL3 A;  3DG8 A;  1RX1 A;  4QLF A;  1KMV A;  2W9H A;  1DR4 A;  3TQB A;  1RA3 A;  2FZH A;  4LEK X;  4IXF X;  3RO9 A;  4EIZ A;  5HVE A;  3IX9 A;  3FY9 X;  3QYL A;  1DRE A;  5HVB A;  4X5F A;  1MVS A;  4KAK A;  3K47 A;  3UM8 A;  1DF7 A;  1IA1 A;  5HQY A;  5CCC A;  4LAG X;  4GH8 A;  4HA9 A;  4LAH X;  1AO8 A;  3GHW A;  3NXV A;  3GHV A;  1DDR A;  1IA3 A;  3QGT A;  3JWK A;  1LY4 A;  1S3U A;  1DYJ A;  3FQF A;  3CD2 A;  3NXY A;  2CIG A;  3FRF X;  3QFX A;  4IXG X;  5HSU A;  3ROA A;  3S7A A;  3SRS X;  4FGH A;  2L28 A;  1SEJ A;  4KM2 A;  3EEL A;  2ANQ A;  1DR2 A;  3SRU X;  3FQ0 A;  4M7V A;  3EEJ A;  3NZD A;  3TQ9 A;  3DAU A;  6DFR A;  1E26 A;  1CZ3 A;  1JUV A;  1RA9 A;  3QLS A;  3JWF A;  1HFQ A;  1MVT A;  3F0Q X;  2HM9 A;  3INV A;  1CD2 A;  5EAJ A;  2JYB A;  4XT7 A;  1DLR A;  3FQO A;  1DR3 A;  4H96 A;  4G3M A;  1BOZ A;  2DHF A;  5ECC A;  3D80 A;  3GI2 A;  3SRW X;  2LF1 A;  3IRN A;  4KBN A;  2XW7 A;  1VDR A;  3SRQ X;  4PST A;  1OHJ A;  3FRA X;  1DRB A;  1S3W A;  3SGY A;  3K45 A;  3QLZ A;  5HPB A;  3ZPG A;  2W3A A;  1S3Y A;  4HOF A;  1RH3 A;  3KY8 A;  3IRO A;  4PSS A;  3R33 A;  8DFR A;  1RX6 A;  1RD7 A;  3KJR A;  4DPD A;  4DFR A;  1M78 A;  3FQV A;  5JG0 X;  1RX3 A;  1YHO A;  1DRF A;  2HQP A;  3LG4 A;  3EEK A;  1KLK A;  1DR7 A;  3F0S X;  3F8Z A;  4X5I A;  1DYR A;  1DAJ A;  4Q0E A;  4H98 A;  3KGY A;  3M08 A;  1RG7 A;  1J3J A;  1PD9 A;  3I3R A;  3FRB X;  1LUD A;  1RX4 A;  3IA4 A;  4OSG A;  1U71 A;  4P68 A;  4M7U A;  4ELE A;  4XEC X;  1PD8 A;  4M6L A;  5U26 A;  3F8Y A;  3DFR A;  4H95 A;  4ELB A;  1RX8 A;  2HXV A;  5HUI A;  3FL8 A;  3ZPC A;  1DG5 A;  1LY3 A;  2P4G A;  3TD8 A;  1OHK A;  4QLG A;  4QLE A;  4X5J A;  5FDA A;  1VJ3 A;  4X5H A;  3JVX A;  1RA8 A;  4ELG A;  3GYF A;  4XT8 A;  5HI6 A;  1M79 A;  5U27 A;  5HT4 A;  4ELF A;  4DDR A;  2BLC A;  2AZN A;  4KJJ A;  3SAI A;  2GD9 A;  4G8Z X;  2W3B A;  3QLY A;  4XT5 A;  4QI9 A;  4HA7 A; 
#chains in the Genus database with same CATH homology
 3N0H A;  4HOG A;  3IRM A;  3HJ3 A;  3JW5 A;  1DR5 A;  3FL9 A;  3NXR A;  3RG9 A;  7DFR A;  1DYH A;  3JWC A;  3NZC X;  5HF2 X;  3QLR A;  4EJ1 A;  4NX6 A;  2OBC A;  2CD2 A;  1ZDR A;  3JTW A;  3NZ6 X;  3EX8 A;  3DAT A;  4FGG A;  1RX5 A;  4PTH A;  4DP3 A;  4G95 A;  2DRC A;  4P3R A;  4XT4 A;  3SA1 A;  3SA2 A;  4QJC A;  4CD2 A;  2OIP A;  3IA5 A;  3DRC A;  3NZA X;  2BL9 A;  1RE7 A;  1DYI A;  1J3K A;  4KJK A;  2D0K A;  1RB3 A;  1U70 A;  5HSR A;  3UM6 A;  3E0B A;  4KY8 A;  3SH2 A;  4ECK A;  2C2S A;  5ECX A;  1RB2 A;  2W3W A;  4KLX A;  1DHJ A;  4M2X A;  4X5G A;  1DG8 A;  1RX7 A;  2W9T A;  4H97 A;  3VCO A;  4KD7 A;  1RC4 A;  1DRA A;  3FY8 X;  3NXX A;  2KGK A;  4XRB A;  4KEB A;  3FYW X;  1DR1 A;  3FQC A;  3QL0 A;  1IA2 A;  1QZF A;  2W3V A;  3CLB A;  3I8A X;  1DHI A;  5HQZ A;  4FHB A;  3DL5 A;  3QG2 A;  1DDS A;  4LAE X;  2FZI A;  4P66 A;  1RX2 A;  3NTZ A;  1DIS A;  2ZZA A;  1M7A A;  3EEM A;  3NXO A;  1JOL A;  3F0V X;  3M09 A;  2H2Q A;  2W9S A;  4M6K A;  1RA2 A;  4PSY A;  3K2H A;  4Q67 A;  4XT6 A;  4DPH A;  2FZJ A;  1PDB A;  1DR6 A;  1DIU A;  2ITH A;  2INQ A;  5HF0 X;  4Q6A A;  3OAF A;  5DFR A;  2B3Z A;  5CC9 A;  3QLX A;  3KJS A;  1J3I A;  3FQZ A;  3NU0 A;  3UM5 A;  1BZF A;  2ANO A;  5JA3 A;  2C2T A;  1DRH A;  3GHC A;  2W3M A;  3NZB X;  4KY4 A;  4Q0D A;  4KJL A;  3FRE X;  4M6J A;  3SQY X;  3F0B X;  3FS6 A;  2G6V A;  1RF7 A;  4NX7 A;  4EIL A;  2D5N A;  3S9U A;  1AOE A;  2QK8 A;  1HFR A;  3SR5 X;  3K74 A;  3CSE A;  4QJZ D;  3F0X X;  3FYV X;  1S3V A;  3QLW A;  2BLB A;  3TQ8 A;  3D84 X;  1U72 A;  3NXT A;  3DL6 A;  3NZ9 X;  4PTJ A;  3DGA A;  3QYO A;  4OR7 A;  3JWM A;  4TU5 X;  1RX9 A;  4KFJ A;  1IA4 A;  3NRR A;  5E8Q A;  3CL9 A;  2W9G A;  4KL9 A;  1AI9 A;  4ELH A;  1HFP A;  3SRR X;  3TQA A;  1TDR A;  1KMS A;  5HT5 A;  4HOE A;  2O7P A;  3JW3 A;  4EIG A;  4KM0 A;  1RA1 A;  4KYA A;  4QHV A;  3F91 A;  1JOM A;  1DG7 A;  3Q1H A;  3L3R A;  4I1N A;  3KFY A;  3HBB A;  4KNE A;  3FRD X;  4I13 A;  4XE6 X;  1D1G A;  5DXV A;  4IXE D;  2BLA A;  3S3V A;  3JSU A;  4PDJ A;  4P3Q A;  3OCH A;  3EIG A;  1DHF A;  3F0U X;  4RGC A;  1DLS A;  3QL3 A;  3DG8 A;  1RX1 A;  4QLF A;  1KMV A;  2W9H A;  1DR4 A;  3TQB A;  1RA3 A;  2FZH A;  4LEK X;  4IXF X;  3RO9 A;  4EIZ A;  5HVE A;  3IX9 A;  3FY9 X;  3QYL A;  1DRE A;  5HVB A;  4X5F A;  1MVS A;  4KAK A;  3K47 A;  3UM8 A;  1DF7 A;  1IA1 A;  5HQY A;  5CCC A;  4LAG X;  4GH8 A;  4HA9 A;  4LAH X;  1AO8 A;  3GHW A;  3NXV A;  3GHV A;  1DDR A;  1IA3 A;  3QGT A;  3JWK A;  1LY4 A;  1S3U A;  1DYJ A;  3FQF A;  3CD2 A;  3NXY A;  2CIG A;  3FRF X;  3QFX A;  4IXG X;  5HSU A;  3ROA A;  3S7A A;  3SRS X;  4FGH A;  2L28 A;  1SEJ A;  4KM2 A;  3EEL A;  2ANQ A;  1DR2 A;  3SRU X;  3FQ0 A;  4M7V A;  3EEJ A;  3NZD A;  3TQ9 A;  3DAU A;  6DFR A;  1E26 A;  1CZ3 A;  1JUV A;  1RA9 A;  3QLS A;  3JWF A;  1HFQ A;  1MVT A;  3F0Q X;  2HM9 A;  3INV A;  1CD2 A;  5EAJ A;  2JYB A;  4XT7 A;  1DLR A;  3FQO A;  1DR3 A;  4H96 A;  4G3M A;  1BOZ A;  2DHF A;  5ECC A;  3D80 A;  3GI2 A;  3SRW X;  2LF1 A;  3IRN A;  4KBN A;  2XW7 A;  1VDR A;  3SRQ X;  4PST A;  1OHJ A;  3FRA X;  1DRB A;  1S3W A;  3SGY A;  3K45 A;  3QLZ A;  5HPB A;  3ZPG A;  2W3A A;  1S3Y A;  4HOF A;  1RH3 A;  3KY8 A;  3IRO A;  4PSS A;  3R33 A;  8DFR A;  1RX6 A;  1RD7 A;  3KJR A;  4DPD A;  4DFR A;  1M78 A;  3FQV A;  5JG0 X;  1RX3 A;  1YHO A;  1DRF A;  2HQP A;  3LG4 A;  3EEK A;  1KLK A;  1DR7 A;  3F0S X;  3F8Z A;  4X5I A;  1DYR A;  1DAJ A;  4Q0E A;  4H98 A;  3KGY A;  3M08 A;  1RG7 A;  1J3J A;  1PD9 A;  3I3R A;  3FRB X;  1LUD A;  1RX4 A;  3IA4 A;  4OSG A;  1U71 A;  4P68 A;  4M7U A;  4ELE A;  4XEC X;  1PD8 A;  4M6L A;  5U26 A;  3F8Y A;  3DFR A;  4H95 A;  4ELB A;  1RX8 A;  2HXV A;  5HUI A;  3FL8 A;  3ZPC A;  1DG5 A;  1LY3 A;  2P4G A;  3TD8 A;  1OHK A;  4QLG A;  4QLE A;  4X5J A;  5FDA A;  1VJ3 A;  4X5H A;  3JVX A;  1RA8 A;  4ELG A;  3GYF A;  4XT8 A;  5HI6 A;  1M79 A;  5U27 A;  5HT4 A;  4ELF A;  4DDR A;  2BLC A;  2AZN A;  4KJJ A;  3SAI A;  2GD9 A;  4G8Z X;  2W3B A;  3QLY A;  4XT5 A;  4QI9 A;  4HA7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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