1MVSA

Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine n9-c10 reverse-bridge antifolate binary complex with human dihydrofolate reductase
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate Reductase
total genus 48
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2002-09-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1mvsA00
1IA4A 3NZBX 1DR1A 1DG7A 4EIGA 1RA8A 3QLYA 4PSTA 3QLRA 4PSYA 1DHJA 1RA3A 1AOEA 2JYBA 5HT4A 2AZNA 1DHIA 4M2XA 1RC4A 4DFRA 3D80A 5E8QA 3CD2A 5HQYA 1BZFA 3JTWA 3IRMA 3S9UA 2HQPA 2BLCA 3DRCA 1M7AA 4H97A 4Q67A 3VCOA 3SRQX 3OAFA 1DYHA 1PD9A 3L3RA 3QYLA 8DFRA 1DF7A 3ZPGA 1SEJA 4IXFX 3QLZA 4CD2A 4X5GA 4G8ZX 4DPHA 2ITHA 4LAHX 3QLWA 4ECKA 4X5JA 4M6LA 3D84X 3UM5A 2W3WA 3QL0A 4M6JA 3FREX 2OBCA 1RE7A 4RGCA 3DG8A 1RX5A 1ZDRA 3Q1HA 4QHVA 1DISA 2ANOA 1VDRA 1DIUA 2DRCA 3IRNA 3SH2A 3JW3A 3EEJA 1DG5A 3SAIA 2GD9A 5DXVA 3QYOA 4NX6A 5CC9A 3SGYA 1DDRA 4ELBA 1DAJA 3S7AA 3EIGA 5JA3A 4XE6X 4ELHA 1DHFA 4LAGX 2ANQA 1U72A 1S3VA 4H96A 3JW5A 5HF2X 3TQAA 3QLXA 3LG4A 4HA9A 5HSUA 2QK8A 1DYIA 4KY8A 4XT7A 5HVEA 3DL5A 3F0QX 3FQCA 5U26A 4FGGA 4KBNA 4HOEA 3SR5X 3ZPCA 3FQ0A 1DR7A 2L28A 3OCHA 1DRHA 3KGYA 4H95A 4G95A 1HFRA 1RX6A 3GHVA 4XT5A 4PTHA 3FYVX 4DDRA 2W3AA 4M7VA 1DR3A 3TQ8A 3EEKA 3HBBA 3SRWX 2D5NA 3EEMA 3FRBX 4KM2A 3FRFX 3JWFA 4EJ1A 3M08A 2CIGA 3K47A 2INQA 4KYAA 1RX1A 5U27A 4XECX 1RB2A 4Q0DA 3EX8A 3F8ZA 1AO8A 3S3VA 4FGHA 1DR2A 3NTZA 4KJKA 1RX2A 5HUIA 3IA4A 1RB3A 3DATA 3RG9A 4KJLA 3FY9X 1LY4A 3CL9A 3SRSX 3KJSA 4HA7A 4M6KA 2OIPA 3JWCA 1DLRA 1DREA 2G6VA 3FQVA 1DG8A 5HSRA 3KJRA 4QI9A 2XW7A 2C2TA 3FQZA 1LUDA 4Q0EA 4X5HA 1YHOA 4M7UA 1RD7A 3GHWA 1KLKA 3K2HA 4OSGA 4P68A 2HM9A 1MVSA 2W9GA 1RX4A 4ELGA 5HPBA 1DR4A 5HI6A 3SA2A 2BLAA 2FZJA 4LAEX 4LEKX 1PDBA 5DFRA 3SRUX 2DHFA 4I1NA 3EELA 3SA1A 2BL9A 1DRBA 3F0BX 3I3RA 2FZIA 1S3WA 3QGTA 3R33A 4P66A 3K45A 4KD7A 1DRFA 1S3UA 4KJJA 2FZHA 2CD2A 1DYJA 1RA1A 3IA5A 4QLGA 4KL9A 3NZAX 5HT5A 3DL6A 3M09A 4KY4A 3GYFA 1CZ3A 1JOLA 3DAUA 2ZZAA 4P3RA 1IA2A 1D1GA 1RX7A 3DFRA 3HJ3A 3NXRA 6DFRA 3N0HA 3FRDX 2HXVA 3INVA 4QLEA 2W9TA 1TDRA 3ROAA 3GHCA 1VJ3A 1DR5A 3QFXA 1KMSA 3NZCX 4GH8A 4XT6A 4I13A 5ECCA 1QZFA 2P4GA 3NRRA 4HOGA 2W3VA 3F0UX 5ECXA 3DGAA 1HFPA 1RH3A 5EAJA 2BLBA 4KM0A 3E0BA 4XT4A 1S3YA 3F0XX 4ELEA 4X5FA 3QG2A 1IA3A 2LF1A 4KFJA 4QJZD 4NX7A 3NXTA 4XT8A 3NXYA 3NXVA 3KFYA 4FHBA 4EILA 4KEBA 3FYWX 5JG0X 3KY8A 1DDSA 1RX3A 3CLBA 1IA1A 1J3JA 1LY3A 4TU5X 4PDJA 3TQBA 5HVBA 1U70A 1RG7A 2KGKA 1U71A 5CCCA 4IXGX 2W9SA 3FRAX 2C2SA 3NZ6X 4G3MA 2W3BA 3NZ9X 3FL9A 1KMVA 1AI9A 3TD8A 1RX9A 3F0VX 1CD2A 4EIZA 2W3MA 3CSEA 3FY8X 4Q6AA 7DFRA 1OHJA 1M79A 4X5IA 2D0KA 1RA2A 3FS6A 5FDAA 4QLFA 1J3IA 3UM8A 1HFQA 3JVXA 1J3KA 3UM6A 5HQZA 4HOFA 4P3QA 3IROA 4XRBA 3NXOA 3JWMA 1JUVA 3FL8A 3QL3A 1E26A 3F91A 3GI2A 4DPDA 4PTJA 4IXED 3TQ9A 2H2QA 4KAKA 2O7PA 3F8YA 3SRRX 3JSUA 3F0SX 3QLSA 1DYRA 4ELFA 3I8AX 1JOMA 1MVTA 4OR7A 1DR6A 1RX8A 1RA9A 3K74A 3NU0A 3NZDA 1BOZA 3RO9A 3FQOA 4H98A 2B3ZA 1OHKA 4QJCA 4PSSA 1PD8A 1M78A 2W9HA 3NXXA 5HF0X 3IX9A 4DP3A 1RF7A 3JWKA 1DRAA 1DLSA 3FQFA 3SQYX 4KNEA 4KLXA
chains in the Genus database with same CATH superfamily
1IA4A 3NZBX 1DR1A 1DG7A 4EIGA 1RA8A 3QLYA 4PSTA 3QLRA 4PSYA 1DHJA 1RA3A 1AOEA 2JYBA 5HT4A 2AZNA 1DHIA 4M2XA 1RC4A 4DFRA 3D80A 5E8QA 3CD2A 5HQYA 1BZFA 3JTWA 3IRMA 3S9UA 2HQPA 2BLCA 3DRCA 1M7AA 4H97A 4Q67A 3VCOA 3SRQX 3OAFA 1DYHA 1PD9A 3L3RA 3QYLA 8DFRA 1DF7A 3ZPGA 1SEJA 4IXFX 3QLZA 4CD2A 4X5GA 4G8ZX 4DPHA 2ITHA 4LAHX 3QLWA 4ECKA 4X5JA 4M6LA 3D84X 3UM5A 2W3WA 3QL0A 4M6JA 3FREX 2OBCA 1RE7A 4RGCA 3DG8A 1RX5A 1ZDRA 3Q1HA 4QHVA 1DISA 2ANOA 1VDRA 1DIUA 2DRCA 3IRNA 3SH2A 3JW3A 3EEJA 1DG5A 3SAIA 2GD9A 5DXVA 3QYOA 4NX6A 5CC9A 3SGYA 1DDRA 4ELBA 1DAJA 3S7AA 3EIGA 5JA3A 4XE6X 4ELHA 1DHFA 4LAGX 2ANQA 1U72A 1S3VA 4H96A 3JW5A 5HF2X 3TQAA 3QLXA 3LG4A 4HA9A 5HSUA 2QK8A 1DYIA 4KY8A 4XT7A 5HVEA 3DL5A 3F0QX 3FQCA 5U26A 4FGGA 4KBNA 4HOEA 3SR5X 3ZPCA 3FQ0A 1DR7A 2L28A 3OCHA 1DRHA 3KGYA 4H95A 4G95A 1HFRA 1RX6A 3GHVA 4XT5A 4PTHA 3FYVX 4DDRA 2W3AA 4M7VA 1DR3A 3TQ8A 3EEKA 3HBBA 3SRWX 2D5NA 3EEMA 3FRBX 4KM2A 3FRFX 3JWFA 4EJ1A 3M08A 2CIGA 3K47A 2INQA 4KYAA 1RX1A 5U27A 4XECX 1RB2A 4Q0DA 3EX8A 3F8ZA 1AO8A 3S3VA 4FGHA 1DR2A 3NTZA 4KJKA 1RX2A 5HUIA 3IA4A 1RB3A 3DATA 3RG9A 4KJLA 3FY9X 1LY4A 3CL9A 3SRSX 3KJSA 4HA7A 4M6KA 2OIPA 3JWCA 1DLRA 1DREA 2G6VA 3FQVA 1DG8A 5HSRA 3KJRA 4QI9A 2XW7A 2C2TA 3FQZA 1LUDA 4Q0EA 4X5HA 1YHOA 4M7UA 1RD7A 3GHWA 1KLKA 3K2HA 4OSGA 4P68A 2HM9A 1MVSA 2W9GA 1RX4A 4ELGA 5HPBA 1DR4A 5HI6A 3SA2A 2BLAA 2FZJA 4LAEX 4LEKX 1PDBA 5DFRA 3SRUX 2DHFA 4I1NA 3EELA 3SA1A 2BL9A 1DRBA 3F0BX 3I3RA 2FZIA 1S3WA 3QGTA 3R33A 4P66A 3K45A 4KD7A 1DRFA 1S3UA 4KJJA 2FZHA 2CD2A 1DYJA 1RA1A 3IA5A 4QLGA 4KL9A 3NZAX 5HT5A 3DL6A 3M09A 4KY4A 3GYFA 1CZ3A 1JOLA 3DAUA 2ZZAA 4P3RA 1IA2A 1D1GA 1RX7A 3DFRA 3HJ3A 3NXRA 6DFRA 3N0HA 3FRDX 2HXVA 3INVA 4QLEA 2W9TA 1TDRA 3ROAA 3GHCA 1VJ3A 1DR5A 3QFXA 1KMSA 3NZCX 4GH8A 4XT6A 4I13A 5ECCA 1QZFA 2P4GA 3NRRA 4HOGA 2W3VA 3F0UX 5ECXA 3DGAA 1HFPA 1RH3A 5EAJA 2BLBA 4KM0A 3E0BA 4XT4A 1S3YA 3F0XX 4ELEA 4X5FA 3QG2A 1IA3A 2LF1A 4KFJA 4QJZD 4NX7A 3NXTA 4XT8A 3NXYA 3NXVA 3KFYA 4FHBA 4EILA 4KEBA 3FYWX 5JG0X 3KY8A 1DDSA 1RX3A 3CLBA 1IA1A 1J3JA 1LY3A 4TU5X 4PDJA 3TQBA 5HVBA 1U70A 1RG7A 2KGKA 1U71A 5CCCA 4IXGX 2W9SA 3FRAX 2C2SA 3NZ6X 4G3MA 2W3BA 3NZ9X 3FL9A 1KMVA 1AI9A 3TD8A 1RX9A 3F0VX 1CD2A 4EIZA 2W3MA 3CSEA 3FY8X 4Q6AA 7DFRA 1OHJA 1M79A 4X5IA 2D0KA 1RA2A 3FS6A 5FDAA 4QLFA 1J3IA 3UM8A 1HFQA 3JVXA 1J3KA 3UM6A 5HQZA 4HOFA 4P3QA 3IROA 4XRBA 3NXOA 3JWMA 1JUVA 3FL8A 3QL3A 1E26A 3F91A 3GI2A 4DPDA 4PTJA 4IXED 3TQ9A 2H2QA 4KAKA 2O7PA 3F8YA 3SRRX 3JSUA 3F0SX 3QLSA 1DYRA 4ELFA 3I8AX 1JOMA 1MVTA 4OR7A 1DR6A 1RX8A 1RA9A 3K74A 3NU0A 3NZDA 1BOZA 3RO9A 3FQOA 4H98A 2B3ZA 1OHKA 4QJCA 4PSSA 1PD8A 1M78A 2W9HA 3NXXA 5HF0X 3IX9A 4DP3A 1RF7A 3JWKA 1DRAA 1DLSA 3FQFA 3SQYX 4KNEA 4KLXA
chains in the Genus database with same CATH topology
1IA4A 3NZBX 1DR1A 1DG7A 4EIGA 1RA8A 3QLYA 4PSTA 3QLRA 4PSYA 1DHJA 1RA3A 1AOEA 2JYBA 5HT4A 2AZNA 1DHIA 4M2XA 1RC4A 4DFRA 3D80A 5E8QA 3CD2A 5HQYA 1BZFA 3JTWA 3IRMA 3S9UA 2HQPA 2BLCA 3DRCA 1M7AA 4H97A 4Q67A 3VCOA 3SRQX 3OAFA 1DYHA 1PD9A 3L3RA 3QYLA 8DFRA 1DF7A 3ZPGA 1SEJA 4IXFX 3QLZA 4CD2A 4X5GA 4G8ZX 4DPHA 2ITHA 4LAHX 3QLWA 4ECKA 4X5JA 4M6LA 3D84X 3UM5A 2W3WA 3QL0A 4M6JA 3FREX 2OBCA 1RE7A 4RGCA 3DG8A 1RX5A 1ZDRA 3Q1HA 4QHVA 1DISA 2ANOA 1VDRA 1DIUA 2DRCA 3IRNA 3SH2A 3JW3A 3EEJA 1DG5A 3SAIA 2GD9A 5DXVA 3QYOA 4NX6A 5CC9A 3SGYA 1DDRA 4ELBA 1DAJA 3S7AA 3EIGA 5JA3A 4XE6X 4ELHA 1DHFA 4LAGX 2ANQA 1U72A 1S3VA 4H96A 3JW5A 5HF2X 3TQAA 3QLXA 3LG4A 4HA9A 5HSUA 2QK8A 1DYIA 4KY8A 4XT7A 5HVEA 3DL5A 3F0QX 3FQCA 5U26A 4FGGA 4KBNA 4HOEA 3SR5X 3ZPCA 3FQ0A 1DR7A 2L28A 3OCHA 1DRHA 3KGYA 4H95A 4G95A 1HFRA 1RX6A 3GHVA 4XT5A 4PTHA 3FYVX 4DDRA 2W3AA 4M7VA 1DR3A 3TQ8A 3EEKA 3HBBA 3SRWX 2D5NA 3EEMA 3FRBX 4KM2A 3FRFX 3JWFA 4EJ1A 3M08A 2CIGA 3K47A 2INQA 4KYAA 1RX1A 5U27A 4XECX 1RB2A 4Q0DA 3EX8A 3F8ZA 1AO8A 3S3VA 4FGHA 1DR2A 3NTZA 4KJKA 1RX2A 5HUIA 3IA4A 1RB3A 3DATA 3RG9A 4KJLA 3FY9X 1LY4A 3CL9A 3SRSX 3KJSA 4HA7A 4M6KA 2OIPA 3JWCA 1DLRA 1DREA 2G6VA 3FQVA 1DG8A 5HSRA 3KJRA 4QI9A 2XW7A 2C2TA 3FQZA 1LUDA 4Q0EA 4X5HA 1YHOA 4M7UA 1RD7A 3GHWA 1KLKA 3K2HA 4OSGA 4P68A 2HM9A 1MVSA 2W9GA 1RX4A 4ELGA 5HPBA 1DR4A 5HI6A 3SA2A 2BLAA 2FZJA 4LAEX 4LEKX 1PDBA 5DFRA 3SRUX 2DHFA 4I1NA 3EELA 3SA1A 2BL9A 1DRBA 3F0BX 3I3RA 2FZIA 1S3WA 3QGTA 3R33A 4P66A 3K45A 4KD7A 1DRFA 1S3UA 4KJJA 2FZHA 2CD2A 1DYJA 1RA1A 3IA5A 4QLGA 4KL9A 3NZAX 5HT5A 3DL6A 3M09A 4KY4A 3GYFA 1CZ3A 1JOLA 3DAUA 2ZZAA 4P3RA 1IA2A 1D1GA 1RX7A 3DFRA 3HJ3A 3NXRA 6DFRA 3N0HA 3FRDX 2HXVA 3INVA 4QLEA 2W9TA 1TDRA 3ROAA 3GHCA 1VJ3A 1DR5A 3QFXA 1KMSA 3NZCX 4GH8A 4XT6A 4I13A 5ECCA 1QZFA 2P4GA 3NRRA 4HOGA 2W3VA 3F0UX 5ECXA 3DGAA 1HFPA 1RH3A 5EAJA 2BLBA 4KM0A 3E0BA 4XT4A 1S3YA 3F0XX 4ELEA 4X5FA 3QG2A 1IA3A 2LF1A 4KFJA 4QJZD 4NX7A 3NXTA 4XT8A 3NXYA 3NXVA 3KFYA 4FHBA 4EILA 4KEBA 3FYWX 5JG0X 3KY8A 1DDSA 1RX3A 3CLBA 1IA1A 1J3JA 1LY3A 4TU5X 4PDJA 3TQBA 5HVBA 1U70A 1RG7A 2KGKA 1U71A 5CCCA 4IXGX 2W9SA 3FRAX 2C2SA 3NZ6X 4G3MA 2W3BA 3NZ9X 3FL9A 1KMVA 1AI9A 3TD8A 1RX9A 3F0VX 1CD2A 4EIZA 2W3MA 3CSEA 3FY8X 4Q6AA 7DFRA 1OHJA 1M79A 4X5IA 2D0KA 1RA2A 3FS6A 5FDAA 4QLFA 1J3IA 3UM8A 1HFQA 3JVXA 1J3KA 3UM6A 5HQZA 4HOFA 4P3QA 3IROA 4XRBA 3NXOA 3JWMA 1JUVA 3FL8A 3QL3A 1E26A 3F91A 3GI2A 4DPDA 4PTJA 4IXED 3TQ9A 2H2QA 4KAKA 2O7PA 3F8YA 3SRRX 3JSUA 3F0SX 3QLSA 1DYRA 4ELFA 3I8AX 1JOMA 1MVTA 4OR7A 1DR6A 1RX8A 1RA9A 3K74A 3NU0A 3NZDA 1BOZA 3RO9A 3FQOA 4H98A 2B3ZA 1OHKA 4QJCA 4PSSA 1PD8A 1M78A 2W9HA 3NXXA 5HF0X 3IX9A 4DP3A 1RF7A 3JWKA 1DRAA 1DLSA 3FQFA 3SQYX 4KNEA 4KLXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IA4 A;  3NZB X;  1DR1 A;  1DG7 A;  4EIG A;  1RA8 A;  3QLY A;  4PST A;  3QLR A;  4PSY A;  1DHJ A;  1RA3 A;  1AOE A;  2JYB A;  5HT4 A;  2AZN A;  1DHI A;  4M2X A;  1RC4 A;  4DFR A;  3D80 A;  5E8Q A;  3CD2 A;  5HQY A;  1BZF A;  3JTW A;  3IRM A;  3S9U A;  2HQP A;  2BLC A;  3DRC A;  1M7A A;  4H97 A;  4Q67 A;  3VCO A;  3SRQ X;  3OAF A;  1DYH A;  1PD9 A;  3L3R A;  3QYL A;  8DFR A;  1DF7 A;  3ZPG A;  1SEJ A;  4IXF X;  3QLZ A;  4CD2 A;  4X5G A;  4G8Z X;  4DPH A;  2ITH A;  4LAH X;  3QLW A;  4ECK A;  4X5J A;  4M6L A;  3D84 X;  3UM5 A;  2W3W A;  3QL0 A;  4M6J A;  3FRE X;  2OBC A;  1RE7 A;  4RGC A;  3DG8 A;  1RX5 A;  1ZDR A;  3Q1H A;  4QHV A;  1DIS A;  2ANO A;  1VDR A;  1DIU A;  2DRC A;  3IRN A;  3SH2 A;  3JW3 A;  3EEJ A;  1DG5 A;  3SAI A;  2GD9 A;  5DXV A;  3QYO A;  4NX6 A;  5CC9 A;  3SGY A;  1DDR A;  4ELB A;  1DAJ A;  3S7A A;  3EIG A;  5JA3 A;  4XE6 X;  4ELH A;  1DHF A;  4LAG X;  2ANQ A;  1U72 A;  1S3V A;  4H96 A;  3JW5 A;  5HF2 X;  3TQA A;  3QLX A;  3LG4 A;  4HA9 A;  5HSU A;  2QK8 A;  1DYI A;  4KY8 A;  4XT7 A;  5HVE A;  3DL5 A;  3F0Q X;  3FQC A;  5U26 A;  4FGG A;  4KBN A;  4HOE A;  3SR5 X;  3ZPC A;  3FQ0 A;  1DR7 A;  2L28 A;  3OCH A;  1DRH A;  3KGY A;  4H95 A;  4G95 A;  1HFR A;  1RX6 A;  3GHV A;  4XT5 A;  4PTH A;  3FYV X;  4DDR A;  2W3A A;  4M7V A;  1DR3 A;  3TQ8 A;  3EEK A;  3HBB A;  3SRW X;  2D5N A;  3EEM A;  3FRB X;  4KM2 A;  3FRF X;  3JWF A;  4EJ1 A;  3M08 A;  2CIG A;  3K47 A;  2INQ A;  4KYA A;  1RX1 A;  5U27 A;  4XEC X;  1RB2 A;  4Q0D A;  3EX8 A;  3F8Z A;  1AO8 A;  3S3V A;  4FGH A;  1DR2 A;  3NTZ A;  4KJK A;  1RX2 A;  5HUI A;  3IA4 A;  1RB3 A;  3DAT A;  3RG9 A;  4KJL A;  3FY9 X;  1LY4 A;  3CL9 A;  3SRS X;  3KJS A;  4HA7 A;  4M6K A;  2OIP A;  3JWC A;  1DLR A;  1DRE A;  2G6V A;  3FQV A;  1DG8 A;  5HSR A;  3KJR A;  4QI9 A;  2XW7 A;  2C2T A;  3FQZ A;  1LUD A;  4Q0E A;  4X5H A;  1YHO A;  4M7U A;  1RD7 A;  3GHW A;  1KLK A;  3K2H A;  4OSG A;  4P68 A;  2HM9 A;  1MVS A;  2W9G A;  1RX4 A;  4ELG A;  5HPB A;  1DR4 A;  5HI6 A;  3SA2 A;  2BLA A;  2FZJ A;  4LAE X;  4LEK X;  1PDB A;  5DFR A;  3SRU X;  2DHF A;  4I1N A;  3EEL A;  3SA1 A;  2BL9 A;  1DRB A;  3F0B X;  3I3R A;  2FZI A;  1S3W A;  3QGT A;  3R33 A;  4P66 A;  3K45 A;  4KD7 A;  1DRF A;  1S3U A;  4KJJ A;  2FZH A;  2CD2 A;  1DYJ A;  1RA1 A;  3IA5 A;  4QLG A;  4KL9 A;  3NZA X;  5HT5 A;  3DL6 A;  3M09 A;  4KY4 A;  3GYF A;  1CZ3 A;  1JOL A;  3DAU A;  2ZZA A;  4P3R A;  1IA2 A;  1D1G A;  1RX7 A;  3DFR A;  3HJ3 A;  3NXR A;  6DFR A;  3N0H A;  3FRD X;  2HXV A;  3INV A;  4QLE A;  2W9T A;  1TDR A;  3ROA A;  3GHC A;  1VJ3 A;  1DR5 A;  3QFX A;  1KMS A;  3NZC X;  4GH8 A;  4XT6 A;  4I13 A;  5ECC A;  1QZF A;  2P4G A;  3NRR A;  4HOG A;  2W3V A;  3F0U X;  5ECX A;  3DGA A;  1HFP A;  1RH3 A;  5EAJ A;  2BLB A;  4KM0 A;  3E0B A;  4XT4 A;  1S3Y A;  3F0X X;  4ELE A;  4X5F A;  3QG2 A;  1IA3 A;  2LF1 A;  4KFJ A;  4QJZ D;  4NX7 A;  3NXT A;  4XT8 A;  3NXY A;  3NXV A;  3KFY A;  4FHB A;  4EIL A;  4KEB A;  3FYW X;  5JG0 X;  3KY8 A;  1DDS A;  1RX3 A;  3CLB A;  1IA1 A;  1J3J A;  1LY3 A;  4TU5 X;  4PDJ A;  3TQB A;  5HVB A;  1U70 A;  1RG7 A;  2KGK A;  1U71 A;  5CCC A;  4IXG X;  2W9S A;  3FRA X;  2C2S A;  3NZ6 X;  4G3M A;  2W3B A;  3NZ9 X;  3FL9 A;  1KMV A;  1AI9 A;  3TD8 A;  1RX9 A;  3F0V X;  1CD2 A;  4EIZ A;  2W3M A;  3CSE A;  3FY8 X;  4Q6A A;  7DFR A;  1OHJ A;  1M79 A;  4X5I A;  2D0K A;  1RA2 A;  3FS6 A;  5FDA A;  4QLF A;  1J3I A;  3UM8 A;  1HFQ A;  3JVX A;  1J3K A;  3UM6 A;  5HQZ A;  4HOF A;  4P3Q A;  3IRO A;  4XRB A;  3NXO A;  3JWM A;  1JUV A;  3FL8 A;  3QL3 A;  1E26 A;  3F91 A;  3GI2 A;  4DPD A;  4PTJ A;  4IXE D;  3TQ9 A;  2H2Q A;  4KAK A;  2O7P A;  3F8Y A;  3SRR X;  3JSU A;  3F0S X;  3QLS A;  1DYR A;  4ELF A;  3I8A X;  1JOM A;  1MVT A;  4OR7 A;  1DR6 A;  1RX8 A;  1RA9 A;  3K74 A;  3NU0 A;  3NZD A;  1BOZ A;  3RO9 A;  3FQO A;  4H98 A;  2B3Z A;  1OHK A;  4QJC A;  4PSS A;  1PD8 A;  1M78 A;  2W9H A;  3NXX A;  5HF0 X;  3IX9 A;  4DP3 A;  1RF7 A;  3JWK A;  1DRA A;  1DLS A;  3FQF A;  3SQY X;  4KNE A;  4KLX A; 
#chains in the Genus database with same CATH topology
 1IA4 A;  3NZB X;  1DR1 A;  1DG7 A;  4EIG A;  1RA8 A;  3QLY A;  4PST A;  3QLR A;  4PSY A;  1DHJ A;  1RA3 A;  1AOE A;  2JYB A;  5HT4 A;  2AZN A;  1DHI A;  4M2X A;  1RC4 A;  4DFR A;  3D80 A;  5E8Q A;  3CD2 A;  5HQY A;  1BZF A;  3JTW A;  3IRM A;  3S9U A;  2HQP A;  2BLC A;  3DRC A;  1M7A A;  4H97 A;  4Q67 A;  3VCO A;  3SRQ X;  3OAF A;  1DYH A;  1PD9 A;  3L3R A;  3QYL A;  8DFR A;  1DF7 A;  3ZPG A;  1SEJ A;  4IXF X;  3QLZ A;  4CD2 A;  4X5G A;  4G8Z X;  4DPH A;  2ITH A;  4LAH X;  3QLW A;  4ECK A;  4X5J A;  4M6L A;  3D84 X;  3UM5 A;  2W3W A;  3QL0 A;  4M6J A;  3FRE X;  2OBC A;  1RE7 A;  4RGC A;  3DG8 A;  1RX5 A;  1ZDR A;  3Q1H A;  4QHV A;  1DIS A;  2ANO A;  1VDR A;  1DIU A;  2DRC A;  3IRN A;  3SH2 A;  3JW3 A;  3EEJ A;  1DG5 A;  3SAI A;  2GD9 A;  5DXV A;  3QYO A;  4NX6 A;  5CC9 A;  3SGY A;  1DDR A;  4ELB A;  1DAJ A;  3S7A A;  3EIG A;  5JA3 A;  4XE6 X;  4ELH A;  1DHF A;  4LAG X;  2ANQ A;  1U72 A;  1S3V A;  4H96 A;  3JW5 A;  5HF2 X;  3TQA A;  3QLX A;  3LG4 A;  4HA9 A;  5HSU A;  2QK8 A;  1DYI A;  4KY8 A;  4XT7 A;  5HVE A;  3DL5 A;  3F0Q X;  3FQC A;  5U26 A;  4FGG A;  4KBN A;  4HOE A;  3SR5 X;  3ZPC A;  3FQ0 A;  1DR7 A;  2L28 A;  3OCH A;  1DRH A;  3KGY A;  4H95 A;  4G95 A;  1HFR A;  1RX6 A;  3GHV A;  4XT5 A;  4PTH A;  3FYV X;  4DDR A;  2W3A A;  4M7V A;  1DR3 A;  3TQ8 A;  3EEK A;  3HBB A;  3SRW X;  2D5N A;  3EEM A;  3FRB X;  4KM2 A;  3FRF X;  3JWF A;  4EJ1 A;  3M08 A;  2CIG A;  3K47 A;  2INQ A;  4KYA A;  1RX1 A;  5U27 A;  4XEC X;  1RB2 A;  4Q0D A;  3EX8 A;  3F8Z A;  1AO8 A;  3S3V A;  4FGH A;  1DR2 A;  3NTZ A;  4KJK A;  1RX2 A;  5HUI A;  3IA4 A;  1RB3 A;  3DAT A;  3RG9 A;  4KJL A;  3FY9 X;  1LY4 A;  3CL9 A;  3SRS X;  3KJS A;  4HA7 A;  4M6K A;  2OIP A;  3JWC A;  1DLR A;  1DRE A;  2G6V A;  3FQV A;  1DG8 A;  5HSR A;  3KJR A;  4QI9 A;  2XW7 A;  2C2T A;  3FQZ A;  1LUD A;  4Q0E A;  4X5H A;  1YHO A;  4M7U A;  1RD7 A;  3GHW A;  1KLK A;  3K2H A;  4OSG A;  4P68 A;  2HM9 A;  1MVS A;  2W9G A;  1RX4 A;  4ELG A;  5HPB A;  1DR4 A;  5HI6 A;  3SA2 A;  2BLA A;  2FZJ A;  4LAE X;  4LEK X;  1PDB A;  5DFR A;  3SRU X;  2DHF A;  4I1N A;  3EEL A;  3SA1 A;  2BL9 A;  1DRB A;  3F0B X;  3I3R A;  2FZI A;  1S3W A;  3QGT A;  3R33 A;  4P66 A;  3K45 A;  4KD7 A;  1DRF A;  1S3U A;  4KJJ A;  2FZH A;  2CD2 A;  1DYJ A;  1RA1 A;  3IA5 A;  4QLG A;  4KL9 A;  3NZA X;  5HT5 A;  3DL6 A;  3M09 A;  4KY4 A;  3GYF A;  1CZ3 A;  1JOL A;  3DAU A;  2ZZA A;  4P3R A;  1IA2 A;  1D1G A;  1RX7 A;  3DFR A;  3HJ3 A;  3NXR A;  6DFR A;  3N0H A;  3FRD X;  2HXV A;  3INV A;  4QLE A;  2W9T A;  1TDR A;  3ROA A;  3GHC A;  1VJ3 A;  1DR5 A;  3QFX A;  1KMS A;  3NZC X;  4GH8 A;  4XT6 A;  4I13 A;  5ECC A;  1QZF A;  2P4G A;  3NRR A;  4HOG A;  2W3V A;  3F0U X;  5ECX A;  3DGA A;  1HFP A;  1RH3 A;  5EAJ A;  2BLB A;  4KM0 A;  3E0B A;  4XT4 A;  1S3Y A;  3F0X X;  4ELE A;  4X5F A;  3QG2 A;  1IA3 A;  2LF1 A;  4KFJ A;  4QJZ D;  4NX7 A;  3NXT A;  4XT8 A;  3NXY A;  3NXV A;  3KFY A;  4FHB A;  4EIL A;  4KEB A;  3FYW X;  5JG0 X;  3KY8 A;  1DDS A;  1RX3 A;  3CLB A;  1IA1 A;  1J3J A;  1LY3 A;  4TU5 X;  4PDJ A;  3TQB A;  5HVB A;  1U70 A;  1RG7 A;  2KGK A;  1U71 A;  5CCC A;  4IXG X;  2W9S A;  3FRA X;  2C2S A;  3NZ6 X;  4G3M A;  2W3B A;  3NZ9 X;  3FL9 A;  1KMV A;  1AI9 A;  3TD8 A;  1RX9 A;  3F0V X;  1CD2 A;  4EIZ A;  2W3M A;  3CSE A;  3FY8 X;  4Q6A A;  7DFR A;  1OHJ A;  1M79 A;  4X5I A;  2D0K A;  1RA2 A;  3FS6 A;  5FDA A;  4QLF A;  1J3I A;  3UM8 A;  1HFQ A;  3JVX A;  1J3K A;  3UM6 A;  5HQZ A;  4HOF A;  4P3Q A;  3IRO A;  4XRB A;  3NXO A;  3JWM A;  1JUV A;  3FL8 A;  3QL3 A;  1E26 A;  3F91 A;  3GI2 A;  4DPD A;  4PTJ A;  4IXE D;  3TQ9 A;  2H2Q A;  4KAK A;  2O7P A;  3F8Y A;  3SRR X;  3JSU A;  3F0S X;  3QLS A;  1DYR A;  4ELF A;  3I8A X;  1JOM A;  1MVT A;  4OR7 A;  1DR6 A;  1RX8 A;  1RA9 A;  3K74 A;  3NU0 A;  3NZD A;  1BOZ A;  3RO9 A;  3FQO A;  4H98 A;  2B3Z A;  1OHK A;  4QJC A;  4PSS A;  1PD8 A;  1M78 A;  2W9H A;  3NXX A;  5HF0 X;  3IX9 A;  4DP3 A;  1RF7 A;  3JWK A;  1DRA A;  1DLS A;  3FQF A;  3SQY X;  4KNE A;  4KLX A; 
#chains in the Genus database with same CATH homology
 1IA4 A;  3NZB X;  1DR1 A;  1DG7 A;  4EIG A;  1RA8 A;  3QLY A;  4PST A;  3QLR A;  4PSY A;  1DHJ A;  1RA3 A;  1AOE A;  2JYB A;  5HT4 A;  2AZN A;  1DHI A;  4M2X A;  1RC4 A;  4DFR A;  3D80 A;  5E8Q A;  3CD2 A;  5HQY A;  1BZF A;  3JTW A;  3IRM A;  3S9U A;  2HQP A;  2BLC A;  3DRC A;  1M7A A;  4H97 A;  4Q67 A;  3VCO A;  3SRQ X;  3OAF A;  1DYH A;  1PD9 A;  3L3R A;  3QYL A;  8DFR A;  1DF7 A;  3ZPG A;  1SEJ A;  4IXF X;  3QLZ A;  4CD2 A;  4X5G A;  4G8Z X;  4DPH A;  2ITH A;  4LAH X;  3QLW A;  4ECK A;  4X5J A;  4M6L A;  3D84 X;  3UM5 A;  2W3W A;  3QL0 A;  4M6J A;  3FRE X;  2OBC A;  1RE7 A;  4RGC A;  3DG8 A;  1RX5 A;  1ZDR A;  3Q1H A;  4QHV A;  1DIS A;  2ANO A;  1VDR A;  1DIU A;  2DRC A;  3IRN A;  3SH2 A;  3JW3 A;  3EEJ A;  1DG5 A;  3SAI A;  2GD9 A;  5DXV A;  3QYO A;  4NX6 A;  5CC9 A;  3SGY A;  1DDR A;  4ELB A;  1DAJ A;  3S7A A;  3EIG A;  5JA3 A;  4XE6 X;  4ELH A;  1DHF A;  4LAG X;  2ANQ A;  1U72 A;  1S3V A;  4H96 A;  3JW5 A;  5HF2 X;  3TQA A;  3QLX A;  3LG4 A;  4HA9 A;  5HSU A;  2QK8 A;  1DYI A;  4KY8 A;  4XT7 A;  5HVE A;  3DL5 A;  3F0Q X;  3FQC A;  5U26 A;  4FGG A;  4KBN A;  4HOE A;  3SR5 X;  3ZPC A;  3FQ0 A;  1DR7 A;  2L28 A;  3OCH A;  1DRH A;  3KGY A;  4H95 A;  4G95 A;  1HFR A;  1RX6 A;  3GHV A;  4XT5 A;  4PTH A;  3FYV X;  4DDR A;  2W3A A;  4M7V A;  1DR3 A;  3TQ8 A;  3EEK A;  3HBB A;  3SRW X;  2D5N A;  3EEM A;  3FRB X;  4KM2 A;  3FRF X;  3JWF A;  4EJ1 A;  3M08 A;  2CIG A;  3K47 A;  2INQ A;  4KYA A;  1RX1 A;  5U27 A;  4XEC X;  1RB2 A;  4Q0D A;  3EX8 A;  3F8Z A;  1AO8 A;  3S3V A;  4FGH A;  1DR2 A;  3NTZ A;  4KJK A;  1RX2 A;  5HUI A;  3IA4 A;  1RB3 A;  3DAT A;  3RG9 A;  4KJL A;  3FY9 X;  1LY4 A;  3CL9 A;  3SRS X;  3KJS A;  4HA7 A;  4M6K A;  2OIP A;  3JWC A;  1DLR A;  1DRE A;  2G6V A;  3FQV A;  1DG8 A;  5HSR A;  3KJR A;  4QI9 A;  2XW7 A;  2C2T A;  3FQZ A;  1LUD A;  4Q0E A;  4X5H A;  1YHO A;  4M7U A;  1RD7 A;  3GHW A;  1KLK A;  3K2H A;  4OSG A;  4P68 A;  2HM9 A;  1MVS A;  2W9G A;  1RX4 A;  4ELG A;  5HPB A;  1DR4 A;  5HI6 A;  3SA2 A;  2BLA A;  2FZJ A;  4LAE X;  4LEK X;  1PDB A;  5DFR A;  3SRU X;  2DHF A;  4I1N A;  3EEL A;  3SA1 A;  2BL9 A;  1DRB A;  3F0B X;  3I3R A;  2FZI A;  1S3W A;  3QGT A;  3R33 A;  4P66 A;  3K45 A;  4KD7 A;  1DRF A;  1S3U A;  4KJJ A;  2FZH A;  2CD2 A;  1DYJ A;  1RA1 A;  3IA5 A;  4QLG A;  4KL9 A;  3NZA X;  5HT5 A;  3DL6 A;  3M09 A;  4KY4 A;  3GYF A;  1CZ3 A;  1JOL A;  3DAU A;  2ZZA A;  4P3R A;  1IA2 A;  1D1G A;  1RX7 A;  3DFR A;  3HJ3 A;  3NXR A;  6DFR A;  3N0H A;  3FRD X;  2HXV A;  3INV A;  4QLE A;  2W9T A;  1TDR A;  3ROA A;  3GHC A;  1VJ3 A;  1DR5 A;  3QFX A;  1KMS A;  3NZC X;  4GH8 A;  4XT6 A;  4I13 A;  5ECC A;  1QZF A;  2P4G A;  3NRR A;  4HOG A;  2W3V A;  3F0U X;  5ECX A;  3DGA A;  1HFP A;  1RH3 A;  5EAJ A;  2BLB A;  4KM0 A;  3E0B A;  4XT4 A;  1S3Y A;  3F0X X;  4ELE A;  4X5F A;  3QG2 A;  1IA3 A;  2LF1 A;  4KFJ A;  4QJZ D;  4NX7 A;  3NXT A;  4XT8 A;  3NXY A;  3NXV A;  3KFY A;  4FHB A;  4EIL A;  4KEB A;  3FYW X;  5JG0 X;  3KY8 A;  1DDS A;  1RX3 A;  3CLB A;  1IA1 A;  1J3J A;  1LY3 A;  4TU5 X;  4PDJ A;  3TQB A;  5HVB A;  1U70 A;  1RG7 A;  2KGK A;  1U71 A;  5CCC A;  4IXG X;  2W9S A;  3FRA X;  2C2S A;  3NZ6 X;  4G3M A;  2W3B A;  3NZ9 X;  3FL9 A;  1KMV A;  1AI9 A;  3TD8 A;  1RX9 A;  3F0V X;  1CD2 A;  4EIZ A;  2W3M A;  3CSE A;  3FY8 X;  4Q6A A;  7DFR A;  1OHJ A;  1M79 A;  4X5I A;  2D0K A;  1RA2 A;  3FS6 A;  5FDA A;  4QLF A;  1J3I A;  3UM8 A;  1HFQ A;  3JVX A;  1J3K A;  3UM6 A;  5HQZ A;  4HOF A;  4P3Q A;  3IRO A;  4XRB A;  3NXO A;  3JWM A;  1JUV A;  3FL8 A;  3QL3 A;  1E26 A;  3F91 A;  3GI2 A;  4DPD A;  4PTJ A;  4IXE D;  3TQ9 A;  2H2Q A;  4KAK A;  2O7P A;  3F8Y A;  3SRR X;  3JSU A;  3F0S X;  3QLS A;  1DYR A;  4ELF A;  3I8A X;  1JOM A;  1MVT A;  4OR7 A;  1DR6 A;  1RX8 A;  1RA9 A;  3K74 A;  3NU0 A;  3NZD A;  1BOZ A;  3RO9 A;  3FQO A;  4H98 A;  2B3Z A;  1OHK A;  4QJC A;  4PSS A;  1PD8 A;  1M78 A;  2W9H A;  3NXX A;  5HF0 X;  3IX9 A;  4DP3 A;  1RF7 A;  3JWK A;  1DRA A;  1DLS A;  3FQF A;  3SQY X;  4KNE A;  4KLX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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