1RH3A

Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (reduced form)
Total Genus 42
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
42
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 42
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1996-11-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1rh3A00
4M6LA 3SR5X 3E0BA 4P66A 1AO8A 4G95A 4P3RA 3CSEA 4M6JA 3FREX 6DFRA 4QHVA 3TQ9A 3NXYA 4H96A 4IXGX 3QYLA 2LF1A 1RX8A 3GYFA 3D84X 3Q1HA 4PTJA 3EELA 4I13A 3SRQX 1PDBA 3JW5A 3NZDA 4KL9A 5HUIA 1AOEA 3FY8X 1DYRA 3DG8A 1RX7A 4ELEA 3HBBA 4DP3A 1J3IA 4OSGA 5HI6A 1DR3A 5HSRA 3S3VA 3KGYA 1DF7A 2JYBA 1MVSA 1RA9A 1S3YA 3M08A 1AI9A 3SRUX 3RO9A 1RH3A 1M78A 3FQFA 1DR2A 3M09A 4KLXA 5HT5A 4XT8A 4Q0EA 1DREA 1DAJA 1QZFA 2H2QA 4XRBA 1RX2A 3EEJA 1RB3A 1JOLA 3S9UA 1DISA 5ECXA 2HM9A 2W3AA 3QLXA 4P3QA 3FRFX 4XE6X 4DPHA 3SA2A 1RX3A 3F0QX 3KJSA 3NZCX 4G3MA 1RG7A 2ITHA 1U70A 3NZ9X 1SEJA 3INVA 1IA3A 2W9SA 3FQOA 1IA2A 3SGYA 3QLWA 1DR1A 3DRCA 3F8ZA 3DAUA 3GHCA 4ECKA 1ZDRA 4ELHA 3F91A 3LG4A 4PSTA 3D80A 5JG0X 3FRBX 2AZNA 5HF0X 4QLGA 3OAFA 1RD7A 4NX7A 3GHVA 3CD2A 3NU0A 3F0XX 2BL9A 3I3RA 3EX8A 4OR7A 5HF2X 4KEBA 3QL3A 3S7AA 1RA3A 2DHFA 3KFYA 8DFRA 1CZ3A 2G6VA 2BLCA 4HOFA 3N0HA 3UM5A 2KGKA 1KMSA 3EEMA 1DG7A 3SH2A 5EAJA 4LAGX 1J3JA 3SAIA 1DYIA 3DATA 1DLSA 2W3MA 1CD2A 1VJ3A 2ZZAA 2HXVA 3F0SX 4X5FA 1DHIA 1DLRA 3K45A 4M7VA 1HFPA 3NZ6X 1TDRA 1VDRA 1YHOA 1JOMA 3JWMA 1DR5A 3KJRA 4KY4A 1DRAA 3F0UX 3CL9A 4LAEX 4M6KA 5HQZA 2W3VA 3F0BX 3FQVA 5U27A 3QLRA 5U26A 4KJJA 4KJKA 4HA9A 5E8QA 3JSUA 4XT7A 3OCHA 1DRBA 4X5GA 2W9GA 1DG8A 3FL8A 5HQYA 3SRRX 3JTWA 2C2SA 4ELGA 4P68A 4KFJA 2C2TA 1BOZA 2DRCA 3FS6A 3NXVA 1HFQA 1DHJA 3R33A 2XW7A 3GHWA 1PD9A 1DR4A 1J3KA 4XECX 2OBCA 4PDJA 4QJCA 7DFRA 2D0KA 4DPDA 1D1GA 3EIGA 3NRRA 3FL9A 3QG2A 1RA2A 4Q0DA 1IA1A 4KNEA 4DDRA 3VCOA 4LAHX 4KM2A 5DXVA 3GI2A 1DR6A 4H98A 4GH8A 4HOGA 1DR7A 1LUDA 1KMVA 5HT4A 1S3VA 4M7UA 3SQYX 3TQBA 3DL6A 1KLKA 4IXED 4TU5X 3UM6A 1JUVA 1DDSA 3F0VX 1DRFA 1E26A 3I8AX 3K2HA 4X5HA 4FGHA 3NZBX 3QYOA 2P4GA 4DFRA 4XT5A 3FQZA 1DYHA 3FRAX 2CIGA 3IRMA 2W3BA 3QGTA 4RGCA 4QLEA 1RX4A 5HPBA 1U71A 3SRSX 5DFRA 2W3WA 3NTZA 3RG9A 1BZFA 3IROA 1DYJA 4PSYA 3DGAA 3EEKA 1M79A 4H97A 3DFRA 1LY4A 5CCCA 1S3WA 4Q67A 3FRDX 4KY8A 4ELFA 1DHFA 3F8YA 3NXTA 3SRWX 1OHJA 1RX1A 1HFRA 1RX6A 1LY3A 3NXRA 2CD2A 3DL5A 2OIPA 3FQ0A 4XT6A 4ELBA 3L3RA 2ANOA 2INQA 4CD2A 4KAKA 3KY8A 1RE7A 1RX5A 2L28A 3JVXA 4KD7A 2FZHA 2BLBA 1RC4A 2GD9A 1RF7A 3NXOA 4EJ1A 1IA4A 3JWCA 5HSUA 3TD8A 3NZAX 2BLAA 2FZJA 4NX6A 3TQAA 4PTHA 4I1NA 3JW3A 2B3ZA 4LEKX 3IX9A 4M2XA 3NXXA 3ROAA 3SA1A 4Q6AA 1PD8A 4H95A 3QLZA 4QJZD 4KJLA 1DG5A 4XT4A 1S3UA 1M7AA 3FYWX 1RX9A 1RB2A 2ANQA 4HOEA 3JWFA 2FZIA 4KBNA 1RA8A 4QLFA 3IRNA 2QK8A 2W9HA 4IXFX 3QL0A 2W9TA 1DIUA 5HVBA 1OHKA 4EILA 3QFXA 3QLSA 2O7PA 1U72A 3FY9X 5FDAA 4KM0A 3K47A 5CC9A 4FHBA 4EIGA 4X5IA 1RA1A 3FYVX 3IA4A 1MVTA 1DDRA 3QLYA 2HQPA 4KYAA 1DRHA 3ZPCA 5JA3A 4EIZA 3ZPGA 3CLBA 4FGGA 3HJ3A 3TQ8A 3JWKA 5ECCA 3K74A 4QI9A 5HVEA 3FQCA 4PSSA 2D5NA 4G8ZX 3IA5A 4HA7A 4X5JA 3UM8A
chains in the Genus database with same CATH superfamily
4M6LA 3SR5X 3E0BA 4P66A 1AO8A 4G95A 4P3RA 3CSEA 4M6JA 3FREX 6DFRA 4QHVA 3TQ9A 3NXYA 4H96A 4IXGX 3QYLA 2LF1A 1RX8A 3GYFA 3D84X 3Q1HA 4PTJA 3EELA 4I13A 3SRQX 1PDBA 3JW5A 3NZDA 4KL9A 5HUIA 1AOEA 3FY8X 1DYRA 3DG8A 1RX7A 4ELEA 3HBBA 4DP3A 1J3IA 4OSGA 5HI6A 1DR3A 5HSRA 3S3VA 3KGYA 1DF7A 2JYBA 1MVSA 1RA9A 1S3YA 3M08A 1AI9A 3SRUX 3RO9A 1RH3A 1M78A 3FQFA 1DR2A 3M09A 4KLXA 5HT5A 4XT8A 4Q0EA 1DREA 1DAJA 1QZFA 2H2QA 4XRBA 1RX2A 3EEJA 1RB3A 1JOLA 3S9UA 1DISA 5ECXA 2HM9A 2W3AA 3QLXA 4P3QA 3FRFX 4XE6X 4DPHA 3SA2A 1RX3A 3F0QX 3KJSA 3NZCX 4G3MA 1RG7A 2ITHA 1U70A 3NZ9X 1SEJA 3INVA 1IA3A 2W9SA 3FQOA 1IA2A 3SGYA 3QLWA 1DR1A 3DRCA 3F8ZA 3DAUA 3GHCA 4ECKA 1ZDRA 4ELHA 3F91A 3LG4A 4PSTA 3D80A 5JG0X 3FRBX 2AZNA 5HF0X 4QLGA 3OAFA 1RD7A 4NX7A 3GHVA 3CD2A 3NU0A 3F0XX 2BL9A 3I3RA 3EX8A 4OR7A 5HF2X 4KEBA 3QL3A 3S7AA 1RA3A 2DHFA 3KFYA 8DFRA 1CZ3A 2G6VA 2BLCA 4HOFA 3N0HA 3UM5A 2KGKA 1KMSA 3EEMA 1DG7A 3SH2A 5EAJA 4LAGX 1J3JA 3SAIA 1DYIA 3DATA 1DLSA 2W3MA 1CD2A 1VJ3A 2ZZAA 2HXVA 3F0SX 4X5FA 1DHIA 1DLRA 3K45A 4M7VA 1HFPA 3NZ6X 1TDRA 1VDRA 1YHOA 1JOMA 3JWMA 1DR5A 3KJRA 4KY4A 1DRAA 3F0UX 3CL9A 4LAEX 4M6KA 5HQZA 2W3VA 3F0BX 3FQVA 5U27A 3QLRA 5U26A 4KJJA 4KJKA 4HA9A 5E8QA 3JSUA 4XT7A 3OCHA 1DRBA 4X5GA 2W9GA 1DG8A 3FL8A 5HQYA 3SRRX 3JTWA 2C2SA 4ELGA 4P68A 4KFJA 2C2TA 1BOZA 2DRCA 3FS6A 3NXVA 1HFQA 1DHJA 3R33A 2XW7A 3GHWA 1PD9A 1DR4A 1J3KA 4XECX 2OBCA 4PDJA 4QJCA 7DFRA 2D0KA 4DPDA 1D1GA 3EIGA 3NRRA 3FL9A 3QG2A 1RA2A 4Q0DA 1IA1A 4KNEA 4DDRA 3VCOA 4LAHX 4KM2A 5DXVA 3GI2A 1DR6A 4H98A 4GH8A 4HOGA 1DR7A 1LUDA 1KMVA 5HT4A 1S3VA 4M7UA 3SQYX 3TQBA 3DL6A 1KLKA 4IXED 4TU5X 3UM6A 1JUVA 1DDSA 3F0VX 1DRFA 1E26A 3I8AX 3K2HA 4X5HA 4FGHA 3NZBX 3QYOA 2P4GA 4DFRA 4XT5A 3FQZA 1DYHA 3FRAX 2CIGA 3IRMA 2W3BA 3QGTA 4RGCA 4QLEA 1RX4A 5HPBA 1U71A 3SRSX 5DFRA 2W3WA 3NTZA 3RG9A 1BZFA 3IROA 1DYJA 4PSYA 3DGAA 3EEKA 1M79A 4H97A 3DFRA 1LY4A 5CCCA 1S3WA 4Q67A 3FRDX 4KY8A 4ELFA 1DHFA 3F8YA 3NXTA 3SRWX 1OHJA 1RX1A 1HFRA 1RX6A 1LY3A 3NXRA 2CD2A 3DL5A 2OIPA 3FQ0A 4XT6A 4ELBA 3L3RA 2ANOA 2INQA 4CD2A 4KAKA 3KY8A 1RE7A 1RX5A 2L28A 3JVXA 4KD7A 2FZHA 2BLBA 1RC4A 2GD9A 1RF7A 3NXOA 4EJ1A 1IA4A 3JWCA 5HSUA 3TD8A 3NZAX 2BLAA 2FZJA 4NX6A 3TQAA 4PTHA 4I1NA 3JW3A 2B3ZA 4LEKX 3IX9A 4M2XA 3NXXA 3ROAA 3SA1A 4Q6AA 1PD8A 4H95A 3QLZA 4QJZD 4KJLA 1DG5A 4XT4A 1S3UA 1M7AA 3FYWX 1RX9A 1RB2A 2ANQA 4HOEA 3JWFA 2FZIA 4KBNA 1RA8A 4QLFA 3IRNA 2QK8A 2W9HA 4IXFX 3QL0A 2W9TA 1DIUA 5HVBA 1OHKA 4EILA 3QFXA 3QLSA 2O7PA 1U72A 3FY9X 5FDAA 4KM0A 3K47A 5CC9A 4FHBA 4EIGA 4X5IA 1RA1A 3FYVX 3IA4A 1MVTA 1DDRA 3QLYA 2HQPA 4KYAA 1DRHA 3ZPCA 5JA3A 4EIZA 3ZPGA 3CLBA 4FGGA 3HJ3A 3TQ8A 3JWKA 5ECCA 3K74A 4QI9A 5HVEA 3FQCA 4PSSA 2D5NA 4G8ZX 3IA5A 4HA7A 4X5JA 3UM8A
chains in the Genus database with same CATH topology
4M6LA 3SR5X 3E0BA 4P66A 1AO8A 4G95A 4P3RA 3CSEA 4M6JA 3FREX 6DFRA 4QHVA 3TQ9A 3NXYA 4H96A 4IXGX 3QYLA 2LF1A 1RX8A 3GYFA 3D84X 3Q1HA 4PTJA 3EELA 4I13A 3SRQX 1PDBA 3JW5A 3NZDA 4KL9A 5HUIA 1AOEA 3FY8X 1DYRA 3DG8A 1RX7A 4ELEA 3HBBA 4DP3A 1J3IA 4OSGA 5HI6A 1DR3A 5HSRA 3S3VA 3KGYA 1DF7A 2JYBA 1MVSA 1RA9A 1S3YA 3M08A 1AI9A 3SRUX 3RO9A 1RH3A 1M78A 3FQFA 1DR2A 3M09A 4KLXA 5HT5A 4XT8A 4Q0EA 1DREA 1DAJA 1QZFA 2H2QA 4XRBA 1RX2A 3EEJA 1RB3A 1JOLA 3S9UA 1DISA 5ECXA 2HM9A 2W3AA 3QLXA 4P3QA 3FRFX 4XE6X 4DPHA 3SA2A 1RX3A 3F0QX 3KJSA 3NZCX 4G3MA 1RG7A 2ITHA 1U70A 3NZ9X 1SEJA 3INVA 1IA3A 2W9SA 3FQOA 1IA2A 3SGYA 3QLWA 1DR1A 3DRCA 3F8ZA 3DAUA 3GHCA 4ECKA 1ZDRA 4ELHA 3F91A 3LG4A 4PSTA 3D80A 5JG0X 3FRBX 2AZNA 5HF0X 4QLGA 3OAFA 1RD7A 4NX7A 3GHVA 3CD2A 3NU0A 3F0XX 2BL9A 3I3RA 3EX8A 4OR7A 5HF2X 4KEBA 3QL3A 3S7AA 1RA3A 2DHFA 3KFYA 8DFRA 1CZ3A 2G6VA 2BLCA 4HOFA 3N0HA 3UM5A 2KGKA 1KMSA 3EEMA 1DG7A 3SH2A 5EAJA 4LAGX 1J3JA 3SAIA 1DYIA 3DATA 1DLSA 2W3MA 1CD2A 1VJ3A 2ZZAA 2HXVA 3F0SX 4X5FA 1DHIA 1DLRA 3K45A 4M7VA 1HFPA 3NZ6X 1TDRA 1VDRA 1YHOA 1JOMA 3JWMA 1DR5A 3KJRA 4KY4A 1DRAA 3F0UX 3CL9A 4LAEX 4M6KA 5HQZA 2W3VA 3F0BX 3FQVA 5U27A 3QLRA 5U26A 4KJJA 4KJKA 4HA9A 5E8QA 3JSUA 4XT7A 3OCHA 1DRBA 4X5GA 2W9GA 1DG8A 3FL8A 5HQYA 3SRRX 3JTWA 2C2SA 4ELGA 4P68A 4KFJA 2C2TA 1BOZA 2DRCA 3FS6A 3NXVA 1HFQA 1DHJA 3R33A 2XW7A 3GHWA 1PD9A 1DR4A 1J3KA 4XECX 2OBCA 4PDJA 4QJCA 7DFRA 2D0KA 4DPDA 1D1GA 3EIGA 3NRRA 3FL9A 3QG2A 1RA2A 4Q0DA 1IA1A 4KNEA 4DDRA 3VCOA 4LAHX 4KM2A 5DXVA 3GI2A 1DR6A 4H98A 4GH8A 4HOGA 1DR7A 1LUDA 1KMVA 5HT4A 1S3VA 4M7UA 3SQYX 3TQBA 3DL6A 1KLKA 4IXED 4TU5X 3UM6A 1JUVA 1DDSA 3F0VX 1DRFA 1E26A 3I8AX 3K2HA 4X5HA 4FGHA 3NZBX 3QYOA 2P4GA 4DFRA 4XT5A 3FQZA 1DYHA 3FRAX 2CIGA 3IRMA 2W3BA 3QGTA 4RGCA 4QLEA 1RX4A 5HPBA 1U71A 3SRSX 5DFRA 2W3WA 3NTZA 3RG9A 1BZFA 3IROA 1DYJA 4PSYA 3DGAA 3EEKA 1M79A 4H97A 3DFRA 1LY4A 5CCCA 1S3WA 4Q67A 3FRDX 4KY8A 4ELFA 1DHFA 3F8YA 3NXTA 3SRWX 1OHJA 1RX1A 1HFRA 1RX6A 1LY3A 3NXRA 2CD2A 3DL5A 2OIPA 3FQ0A 4XT6A 4ELBA 3L3RA 2ANOA 2INQA 4CD2A 4KAKA 3KY8A 1RE7A 1RX5A 2L28A 3JVXA 4KD7A 2FZHA 2BLBA 1RC4A 2GD9A 1RF7A 3NXOA 4EJ1A 1IA4A 3JWCA 5HSUA 3TD8A 3NZAX 2BLAA 2FZJA 4NX6A 3TQAA 4PTHA 4I1NA 3JW3A 2B3ZA 4LEKX 3IX9A 4M2XA 3NXXA 3ROAA 3SA1A 4Q6AA 1PD8A 4H95A 3QLZA 4QJZD 4KJLA 1DG5A 4XT4A 1S3UA 1M7AA 3FYWX 1RX9A 1RB2A 2ANQA 4HOEA 3JWFA 2FZIA 4KBNA 1RA8A 4QLFA 3IRNA 2QK8A 2W9HA 4IXFX 3QL0A 2W9TA 1DIUA 5HVBA 1OHKA 4EILA 3QFXA 3QLSA 2O7PA 1U72A 3FY9X 5FDAA 4KM0A 3K47A 5CC9A 4FHBA 4EIGA 4X5IA 1RA1A 3FYVX 3IA4A 1MVTA 1DDRA 3QLYA 2HQPA 4KYAA 1DRHA 3ZPCA 5JA3A 4EIZA 3ZPGA 3CLBA 4FGGA 3HJ3A 3TQ8A 3JWKA 5ECCA 3K74A 4QI9A 5HVEA 3FQCA 4PSSA 2D5NA 4G8ZX 3IA5A 4HA7A 4X5JA 3UM8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4M6L A;  3SR5 X;  3E0B A;  4P66 A;  1AO8 A;  4G95 A;  4P3R A;  3CSE A;  4M6J A;  3FRE X;  6DFR A;  4QHV A;  3TQ9 A;  3NXY A;  4H96 A;  4IXG X;  3QYL A;  2LF1 A;  1RX8 A;  3GYF A;  3D84 X;  3Q1H A;  4PTJ A;  3EEL A;  4I13 A;  3SRQ X;  1PDB A;  3JW5 A;  3NZD A;  4KL9 A;  5HUI A;  1AOE A;  3FY8 X;  1DYR A;  3DG8 A;  1RX7 A;  4ELE A;  3HBB A;  4DP3 A;  1J3I A;  4OSG A;  5HI6 A;  1DR3 A;  5HSR A;  3S3V A;  3KGY A;  1DF7 A;  2JYB A;  1MVS A;  1RA9 A;  1S3Y A;  3M08 A;  1AI9 A;  3SRU X;  3RO9 A;  1RH3 A;  1M78 A;  3FQF A;  1DR2 A;  3M09 A;  4KLX A;  5HT5 A;  4XT8 A;  4Q0E A;  1DRE A;  1DAJ A;  1QZF A;  2H2Q A;  4XRB A;  1RX2 A;  3EEJ A;  1RB3 A;  1JOL A;  3S9U A;  1DIS A;  5ECX A;  2HM9 A;  2W3A A;  3QLX A;  4P3Q A;  3FRF X;  4XE6 X;  4DPH A;  3SA2 A;  1RX3 A;  3F0Q X;  3KJS A;  3NZC X;  4G3M A;  1RG7 A;  2ITH A;  1U70 A;  3NZ9 X;  1SEJ A;  3INV A;  1IA3 A;  2W9S A;  3FQO A;  1IA2 A;  3SGY A;  3QLW A;  1DR1 A;  3DRC A;  3F8Z A;  3DAU A;  3GHC A;  4ECK A;  1ZDR A;  4ELH A;  3F91 A;  3LG4 A;  4PST A;  3D80 A;  5JG0 X;  3FRB X;  2AZN A;  5HF0 X;  4QLG A;  3OAF A;  1RD7 A;  4NX7 A;  3GHV A;  3CD2 A;  3NU0 A;  3F0X X;  2BL9 A;  3I3R A;  3EX8 A;  4OR7 A;  5HF2 X;  4KEB A;  3QL3 A;  3S7A A;  1RA3 A;  2DHF A;  3KFY A;  8DFR A;  1CZ3 A;  2G6V A;  2BLC A;  4HOF A;  3N0H A;  3UM5 A;  2KGK A;  1KMS A;  3EEM A;  1DG7 A;  3SH2 A;  5EAJ A;  4LAG X;  1J3J A;  3SAI A;  1DYI A;  3DAT A;  1DLS A;  2W3M A;  1CD2 A;  1VJ3 A;  2ZZA A;  2HXV A;  3F0S X;  4X5F A;  1DHI A;  1DLR A;  3K45 A;  4M7V A;  1HFP A;  3NZ6 X;  1TDR A;  1VDR A;  1YHO A;  1JOM A;  3JWM A;  1DR5 A;  3KJR A;  4KY4 A;  1DRA A;  3F0U X;  3CL9 A;  4LAE X;  4M6K A;  5HQZ A;  2W3V A;  3F0B X;  3FQV A;  5U27 A;  3QLR A;  5U26 A;  4KJJ A;  4KJK A;  4HA9 A;  5E8Q A;  3JSU A;  4XT7 A;  3OCH A;  1DRB A;  4X5G A;  2W9G A;  1DG8 A;  3FL8 A;  5HQY A;  3SRR X;  3JTW A;  2C2S A;  4ELG A;  4P68 A;  4KFJ A;  2C2T A;  1BOZ A;  2DRC A;  3FS6 A;  3NXV A;  1HFQ A;  1DHJ A;  3R33 A;  2XW7 A;  3GHW A;  1PD9 A;  1DR4 A;  1J3K A;  4XEC X;  2OBC A;  4PDJ A;  4QJC A;  7DFR A;  2D0K A;  4DPD A;  1D1G A;  3EIG A;  3NRR A;  3FL9 A;  3QG2 A;  1RA2 A;  4Q0D A;  1IA1 A;  4KNE A;  4DDR A;  3VCO A;  4LAH X;  4KM2 A;  5DXV A;  3GI2 A;  1DR6 A;  4H98 A;  4GH8 A;  4HOG A;  1DR7 A;  1LUD A;  1KMV A;  5HT4 A;  1S3V A;  4M7U A;  3SQY X;  3TQB A;  3DL6 A;  1KLK A;  4IXE D;  4TU5 X;  3UM6 A;  1JUV A;  1DDS A;  3F0V X;  1DRF A;  1E26 A;  3I8A X;  3K2H A;  4X5H A;  4FGH A;  3NZB X;  3QYO A;  2P4G A;  4DFR A;  4XT5 A;  3FQZ A;  1DYH A;  3FRA X;  2CIG A;  3IRM A;  2W3B A;  3QGT A;  4RGC A;  4QLE A;  1RX4 A;  5HPB A;  1U71 A;  3SRS X;  5DFR A;  2W3W A;  3NTZ A;  3RG9 A;  1BZF A;  3IRO A;  1DYJ A;  4PSY A;  3DGA A;  3EEK A;  1M79 A;  4H97 A;  3DFR A;  1LY4 A;  5CCC A;  1S3W A;  4Q67 A;  3FRD X;  4KY8 A;  4ELF A;  1DHF A;  3F8Y A;  3NXT A;  3SRW X;  1OHJ A;  1RX1 A;  1HFR A;  1RX6 A;  1LY3 A;  3NXR A;  2CD2 A;  3DL5 A;  2OIP A;  3FQ0 A;  4XT6 A;  4ELB A;  3L3R A;  2ANO A;  2INQ A;  4CD2 A;  4KAK A;  3KY8 A;  1RE7 A;  1RX5 A;  2L28 A;  3JVX A;  4KD7 A;  2FZH A;  2BLB A;  1RC4 A;  2GD9 A;  1RF7 A;  3NXO A;  4EJ1 A;  1IA4 A;  3JWC A;  5HSU A;  3TD8 A;  3NZA X;  2BLA A;  2FZJ A;  4NX6 A;  3TQA A;  4PTH A;  4I1N A;  3JW3 A;  2B3Z A;  4LEK X;  3IX9 A;  4M2X A;  3NXX A;  3ROA A;  3SA1 A;  4Q6A A;  1PD8 A;  4H95 A;  3QLZ A;  4QJZ D;  4KJL A;  1DG5 A;  4XT4 A;  1S3U A;  1M7A A;  3FYW X;  1RX9 A;  1RB2 A;  2ANQ A;  4HOE A;  3JWF A;  2FZI A;  4KBN A;  1RA8 A;  4QLF A;  3IRN A;  2QK8 A;  2W9H A;  4IXF X;  3QL0 A;  2W9T A;  1DIU A;  5HVB A;  1OHK A;  4EIL A;  3QFX A;  3QLS A;  2O7P A;  1U72 A;  3FY9 X;  5FDA A;  4KM0 A;  3K47 A;  5CC9 A;  4FHB A;  4EIG A;  4X5I A;  1RA1 A;  3FYV X;  3IA4 A;  1MVT A;  1DDR A;  3QLY A;  2HQP A;  4KYA A;  1DRH A;  3ZPC A;  5JA3 A;  4EIZ A;  3ZPG A;  3CLB A;  4FGG A;  3HJ3 A;  3TQ8 A;  3JWK A;  5ECC A;  3K74 A;  4QI9 A;  5HVE A;  3FQC A;  4PSS A;  2D5N A;  4G8Z X;  3IA5 A;  4HA7 A;  4X5J A;  3UM8 A; 
#chains in the Genus database with same CATH topology
 4M6L A;  3SR5 X;  3E0B A;  4P66 A;  1AO8 A;  4G95 A;  4P3R A;  3CSE A;  4M6J A;  3FRE X;  6DFR A;  4QHV A;  3TQ9 A;  3NXY A;  4H96 A;  4IXG X;  3QYL A;  2LF1 A;  1RX8 A;  3GYF A;  3D84 X;  3Q1H A;  4PTJ A;  3EEL A;  4I13 A;  3SRQ X;  1PDB A;  3JW5 A;  3NZD A;  4KL9 A;  5HUI A;  1AOE A;  3FY8 X;  1DYR A;  3DG8 A;  1RX7 A;  4ELE A;  3HBB A;  4DP3 A;  1J3I A;  4OSG A;  5HI6 A;  1DR3 A;  5HSR A;  3S3V A;  3KGY A;  1DF7 A;  2JYB A;  1MVS A;  1RA9 A;  1S3Y A;  3M08 A;  1AI9 A;  3SRU X;  3RO9 A;  1RH3 A;  1M78 A;  3FQF A;  1DR2 A;  3M09 A;  4KLX A;  5HT5 A;  4XT8 A;  4Q0E A;  1DRE A;  1DAJ A;  1QZF A;  2H2Q A;  4XRB A;  1RX2 A;  3EEJ A;  1RB3 A;  1JOL A;  3S9U A;  1DIS A;  5ECX A;  2HM9 A;  2W3A A;  3QLX A;  4P3Q A;  3FRF X;  4XE6 X;  4DPH A;  3SA2 A;  1RX3 A;  3F0Q X;  3KJS A;  3NZC X;  4G3M A;  1RG7 A;  2ITH A;  1U70 A;  3NZ9 X;  1SEJ A;  3INV A;  1IA3 A;  2W9S A;  3FQO A;  1IA2 A;  3SGY A;  3QLW A;  1DR1 A;  3DRC A;  3F8Z A;  3DAU A;  3GHC A;  4ECK A;  1ZDR A;  4ELH A;  3F91 A;  3LG4 A;  4PST A;  3D80 A;  5JG0 X;  3FRB X;  2AZN A;  5HF0 X;  4QLG A;  3OAF A;  1RD7 A;  4NX7 A;  3GHV A;  3CD2 A;  3NU0 A;  3F0X X;  2BL9 A;  3I3R A;  3EX8 A;  4OR7 A;  5HF2 X;  4KEB A;  3QL3 A;  3S7A A;  1RA3 A;  2DHF A;  3KFY A;  8DFR A;  1CZ3 A;  2G6V A;  2BLC A;  4HOF A;  3N0H A;  3UM5 A;  2KGK A;  1KMS A;  3EEM A;  1DG7 A;  3SH2 A;  5EAJ A;  4LAG X;  1J3J A;  3SAI A;  1DYI A;  3DAT A;  1DLS A;  2W3M A;  1CD2 A;  1VJ3 A;  2ZZA A;  2HXV A;  3F0S X;  4X5F A;  1DHI A;  1DLR A;  3K45 A;  4M7V A;  1HFP A;  3NZ6 X;  1TDR A;  1VDR A;  1YHO A;  1JOM A;  3JWM A;  1DR5 A;  3KJR A;  4KY4 A;  1DRA A;  3F0U X;  3CL9 A;  4LAE X;  4M6K A;  5HQZ A;  2W3V A;  3F0B X;  3FQV A;  5U27 A;  3QLR A;  5U26 A;  4KJJ A;  4KJK A;  4HA9 A;  5E8Q A;  3JSU A;  4XT7 A;  3OCH A;  1DRB A;  4X5G A;  2W9G A;  1DG8 A;  3FL8 A;  5HQY A;  3SRR X;  3JTW A;  2C2S A;  4ELG A;  4P68 A;  4KFJ A;  2C2T A;  1BOZ A;  2DRC A;  3FS6 A;  3NXV A;  1HFQ A;  1DHJ A;  3R33 A;  2XW7 A;  3GHW A;  1PD9 A;  1DR4 A;  1J3K A;  4XEC X;  2OBC A;  4PDJ A;  4QJC A;  7DFR A;  2D0K A;  4DPD A;  1D1G A;  3EIG A;  3NRR A;  3FL9 A;  3QG2 A;  1RA2 A;  4Q0D A;  1IA1 A;  4KNE A;  4DDR A;  3VCO A;  4LAH X;  4KM2 A;  5DXV A;  3GI2 A;  1DR6 A;  4H98 A;  4GH8 A;  4HOG A;  1DR7 A;  1LUD A;  1KMV A;  5HT4 A;  1S3V A;  4M7U A;  3SQY X;  3TQB A;  3DL6 A;  1KLK A;  4IXE D;  4TU5 X;  3UM6 A;  1JUV A;  1DDS A;  3F0V X;  1DRF A;  1E26 A;  3I8A X;  3K2H A;  4X5H A;  4FGH A;  3NZB X;  3QYO A;  2P4G A;  4DFR A;  4XT5 A;  3FQZ A;  1DYH A;  3FRA X;  2CIG A;  3IRM A;  2W3B A;  3QGT A;  4RGC A;  4QLE A;  1RX4 A;  5HPB A;  1U71 A;  3SRS X;  5DFR A;  2W3W A;  3NTZ A;  3RG9 A;  1BZF A;  3IRO A;  1DYJ A;  4PSY A;  3DGA A;  3EEK A;  1M79 A;  4H97 A;  3DFR A;  1LY4 A;  5CCC A;  1S3W A;  4Q67 A;  3FRD X;  4KY8 A;  4ELF A;  1DHF A;  3F8Y A;  3NXT A;  3SRW X;  1OHJ A;  1RX1 A;  1HFR A;  1RX6 A;  1LY3 A;  3NXR A;  2CD2 A;  3DL5 A;  2OIP A;  3FQ0 A;  4XT6 A;  4ELB A;  3L3R A;  2ANO A;  2INQ A;  4CD2 A;  4KAK A;  3KY8 A;  1RE7 A;  1RX5 A;  2L28 A;  3JVX A;  4KD7 A;  2FZH A;  2BLB A;  1RC4 A;  2GD9 A;  1RF7 A;  3NXO A;  4EJ1 A;  1IA4 A;  3JWC A;  5HSU A;  3TD8 A;  3NZA X;  2BLA A;  2FZJ A;  4NX6 A;  3TQA A;  4PTH A;  4I1N A;  3JW3 A;  2B3Z A;  4LEK X;  3IX9 A;  4M2X A;  3NXX A;  3ROA A;  3SA1 A;  4Q6A A;  1PD8 A;  4H95 A;  3QLZ A;  4QJZ D;  4KJL A;  1DG5 A;  4XT4 A;  1S3U A;  1M7A A;  3FYW X;  1RX9 A;  1RB2 A;  2ANQ A;  4HOE A;  3JWF A;  2FZI A;  4KBN A;  1RA8 A;  4QLF A;  3IRN A;  2QK8 A;  2W9H A;  4IXF X;  3QL0 A;  2W9T A;  1DIU A;  5HVB A;  1OHK A;  4EIL A;  3QFX A;  3QLS A;  2O7P A;  1U72 A;  3FY9 X;  5FDA A;  4KM0 A;  3K47 A;  5CC9 A;  4FHB A;  4EIG A;  4X5I A;  1RA1 A;  3FYV X;  3IA4 A;  1MVT A;  1DDR A;  3QLY A;  2HQP A;  4KYA A;  1DRH A;  3ZPC A;  5JA3 A;  4EIZ A;  3ZPG A;  3CLB A;  4FGG A;  3HJ3 A;  3TQ8 A;  3JWK A;  5ECC A;  3K74 A;  4QI9 A;  5HVE A;  3FQC A;  4PSS A;  2D5N A;  4G8Z X;  3IA5 A;  4HA7 A;  4X5J A;  3UM8 A; 
#chains in the Genus database with same CATH homology
 4M6L A;  3SR5 X;  3E0B A;  4P66 A;  1AO8 A;  4G95 A;  4P3R A;  3CSE A;  4M6J A;  3FRE X;  6DFR A;  4QHV A;  3TQ9 A;  3NXY A;  4H96 A;  4IXG X;  3QYL A;  2LF1 A;  1RX8 A;  3GYF A;  3D84 X;  3Q1H A;  4PTJ A;  3EEL A;  4I13 A;  3SRQ X;  1PDB A;  3JW5 A;  3NZD A;  4KL9 A;  5HUI A;  1AOE A;  3FY8 X;  1DYR A;  3DG8 A;  1RX7 A;  4ELE A;  3HBB A;  4DP3 A;  1J3I A;  4OSG A;  5HI6 A;  1DR3 A;  5HSR A;  3S3V A;  3KGY A;  1DF7 A;  2JYB A;  1MVS A;  1RA9 A;  1S3Y A;  3M08 A;  1AI9 A;  3SRU X;  3RO9 A;  1RH3 A;  1M78 A;  3FQF A;  1DR2 A;  3M09 A;  4KLX A;  5HT5 A;  4XT8 A;  4Q0E A;  1DRE A;  1DAJ A;  1QZF A;  2H2Q A;  4XRB A;  1RX2 A;  3EEJ A;  1RB3 A;  1JOL A;  3S9U A;  1DIS A;  5ECX A;  2HM9 A;  2W3A A;  3QLX A;  4P3Q A;  3FRF X;  4XE6 X;  4DPH A;  3SA2 A;  1RX3 A;  3F0Q X;  3KJS A;  3NZC X;  4G3M A;  1RG7 A;  2ITH A;  1U70 A;  3NZ9 X;  1SEJ A;  3INV A;  1IA3 A;  2W9S A;  3FQO A;  1IA2 A;  3SGY A;  3QLW A;  1DR1 A;  3DRC A;  3F8Z A;  3DAU A;  3GHC A;  4ECK A;  1ZDR A;  4ELH A;  3F91 A;  3LG4 A;  4PST A;  3D80 A;  5JG0 X;  3FRB X;  2AZN A;  5HF0 X;  4QLG A;  3OAF A;  1RD7 A;  4NX7 A;  3GHV A;  3CD2 A;  3NU0 A;  3F0X X;  2BL9 A;  3I3R A;  3EX8 A;  4OR7 A;  5HF2 X;  4KEB A;  3QL3 A;  3S7A A;  1RA3 A;  2DHF A;  3KFY A;  8DFR A;  1CZ3 A;  2G6V A;  2BLC A;  4HOF A;  3N0H A;  3UM5 A;  2KGK A;  1KMS A;  3EEM A;  1DG7 A;  3SH2 A;  5EAJ A;  4LAG X;  1J3J A;  3SAI A;  1DYI A;  3DAT A;  1DLS A;  2W3M A;  1CD2 A;  1VJ3 A;  2ZZA A;  2HXV A;  3F0S X;  4X5F A;  1DHI A;  1DLR A;  3K45 A;  4M7V A;  1HFP A;  3NZ6 X;  1TDR A;  1VDR A;  1YHO A;  1JOM A;  3JWM A;  1DR5 A;  3KJR A;  4KY4 A;  1DRA A;  3F0U X;  3CL9 A;  4LAE X;  4M6K A;  5HQZ A;  2W3V A;  3F0B X;  3FQV A;  5U27 A;  3QLR A;  5U26 A;  4KJJ A;  4KJK A;  4HA9 A;  5E8Q A;  3JSU A;  4XT7 A;  3OCH A;  1DRB A;  4X5G A;  2W9G A;  1DG8 A;  3FL8 A;  5HQY A;  3SRR X;  3JTW A;  2C2S A;  4ELG A;  4P68 A;  4KFJ A;  2C2T A;  1BOZ A;  2DRC A;  3FS6 A;  3NXV A;  1HFQ A;  1DHJ A;  3R33 A;  2XW7 A;  3GHW A;  1PD9 A;  1DR4 A;  1J3K A;  4XEC X;  2OBC A;  4PDJ A;  4QJC A;  7DFR A;  2D0K A;  4DPD A;  1D1G A;  3EIG A;  3NRR A;  3FL9 A;  3QG2 A;  1RA2 A;  4Q0D A;  1IA1 A;  4KNE A;  4DDR A;  3VCO A;  4LAH X;  4KM2 A;  5DXV A;  3GI2 A;  1DR6 A;  4H98 A;  4GH8 A;  4HOG A;  1DR7 A;  1LUD A;  1KMV A;  5HT4 A;  1S3V A;  4M7U A;  3SQY X;  3TQB A;  3DL6 A;  1KLK A;  4IXE D;  4TU5 X;  3UM6 A;  1JUV A;  1DDS A;  3F0V X;  1DRF A;  1E26 A;  3I8A X;  3K2H A;  4X5H A;  4FGH A;  3NZB X;  3QYO A;  2P4G A;  4DFR A;  4XT5 A;  3FQZ A;  1DYH A;  3FRA X;  2CIG A;  3IRM A;  2W3B A;  3QGT A;  4RGC A;  4QLE A;  1RX4 A;  5HPB A;  1U71 A;  3SRS X;  5DFR A;  2W3W A;  3NTZ A;  3RG9 A;  1BZF A;  3IRO A;  1DYJ A;  4PSY A;  3DGA A;  3EEK A;  1M79 A;  4H97 A;  3DFR A;  1LY4 A;  5CCC A;  1S3W A;  4Q67 A;  3FRD X;  4KY8 A;  4ELF A;  1DHF A;  3F8Y A;  3NXT A;  3SRW X;  1OHJ A;  1RX1 A;  1HFR A;  1RX6 A;  1LY3 A;  3NXR A;  2CD2 A;  3DL5 A;  2OIP A;  3FQ0 A;  4XT6 A;  4ELB A;  3L3R A;  2ANO A;  2INQ A;  4CD2 A;  4KAK A;  3KY8 A;  1RE7 A;  1RX5 A;  2L28 A;  3JVX A;  4KD7 A;  2FZH A;  2BLB A;  1RC4 A;  2GD9 A;  1RF7 A;  3NXO A;  4EJ1 A;  1IA4 A;  3JWC A;  5HSU A;  3TD8 A;  3NZA X;  2BLA A;  2FZJ A;  4NX6 A;  3TQA A;  4PTH A;  4I1N A;  3JW3 A;  2B3Z A;  4LEK X;  3IX9 A;  4M2X A;  3NXX A;  3ROA A;  3SA1 A;  4Q6A A;  1PD8 A;  4H95 A;  3QLZ A;  4QJZ D;  4KJL A;  1DG5 A;  4XT4 A;  1S3U A;  1M7A A;  3FYW X;  1RX9 A;  1RB2 A;  2ANQ A;  4HOE A;  3JWF A;  2FZI A;  4KBN A;  1RA8 A;  4QLF A;  3IRN A;  2QK8 A;  2W9H A;  4IXF X;  3QL0 A;  2W9T A;  1DIU A;  5HVB A;  1OHK A;  4EIL A;  3QFX A;  3QLS A;  2O7P A;  1U72 A;  3FY9 X;  5FDA A;  4KM0 A;  3K47 A;  5CC9 A;  4FHB A;  4EIG A;  4X5I A;  1RA1 A;  3FYV X;  3IA4 A;  1MVT A;  1DDR A;  3QLY A;  2HQP A;  4KYA A;  1DRH A;  3ZPC A;  5JA3 A;  4EIZ A;  3ZPG A;  3CLB A;  4FGG A;  3HJ3 A;  3TQ8 A;  3JWK A;  5ECC A;  3K74 A;  4QI9 A;  5HVE A;  3FQC A;  4PSS A;  2D5N A;  4G8Z X;  3IA5 A;  4HA7 A;  4X5J A;  3UM8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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