1S3UA

Structure determination of tetrahydroquinazoline antifolates in complex with human and pneumocystis carinii dihydrofolate reductase: correlations of enzyme selectivity and stereochemistry
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 52
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2004-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1s3uA00
3DGAA 1AOEA 1S3VA 3DL5A 3D80A 4M2XA 3QG2A 2ANQA 5HF0X 3F0BX 4XT7A 4XECX 3K2HA 3GYFA 1DIUA 2W3MA 3DL6A 1RC4A 4DPDA 3IA4A 1RA3A 3NZBX 1DG5A 4M7UA 5HQZA 3EIGA 1KMVA 3SQYX 4ELEA 3M09A 3ROAA 1RB2A 2HQPA 3TQ9A 2W9SA 4XT8A 1M7AA 1U71A 2DRCA 4KJJA 3S3VA 4RGCA 3JVXA 3F8ZA 4FHBA 3EELA 1M79A 4LAGX 4X5HA 3EX8A 1RX8A 4KEBA 3OCHA 1M78A 3JW3A 5HSUA 1DLSA 3ZPCA 1PDBA 5HT4A 4DDRA 4H96A 3S9UA 1DYIA 2W3VA 3IX9A 3F0QX 3QLYA 4HOGA 3SAIA 3NXXA 4XE6X 1J3KA 1DDSA 1IA1A 1PD8A 3KFYA 2W3BA 3QYOA 4NX7A 1KLKA 2W3AA 1LY4A 1U72A 3D84X 2JYBA 1JOMA 4Q6AA 3FY8X 1AO8A 3NRRA 5ECXA 5HT5A 2HM9A 1RX6A 1IA4A 3JWFA 3FRAX 1LUDA 3FRFX 1DRFA 4XT5A 2KGKA 3SR5X 4OSGA 5EAJA 1DLRA 1DR4A 3QL3A 2ZZAA 4CD2A 4ELFA 5DXVA 1CD2A 1KMSA 4KD7A 4PTHA 4ELHA 1ZDRA 4Q67A 2XW7A 3FQCA 3EEJA 4EIZA 3NZDA 2QK8A 3F0UX 3UM6A 4M7VA 3QYLA 2BL9A 1DRAA 3UM5A 1OHJA 4XT4A 3NXYA 4P66A 1SEJA 3DFRA 1U70A 4P68A 3TD8A 3F0XX 3CLBA 5HF2X 3GHVA 3KGYA 3VCOA 5ECCA 1DHJA 4H97A 1VJ3A 2OBCA 7DFRA 3KY8A 4HA9A 4Q0EA 4G95A 1RA2A 1RX4A 1DG7A 4KM2A 1J3IA 2BLBA 2C2TA 3QLWA 2FZHA 1J3JA 4KY4A 1IA2A 4H95A 5HUIA 2G6VA 2H2QA 5CCCA 4PTJA 1PD9A 2O7PA 2OIPA 4LEKX 1BZFA 3FQ0A 1YHOA 3I3RA 1LY3A 3QLRA 1RX3A 3FL8A 3SRSX 2HXVA 3JW5A 2P4GA 4H98A 1DISA 3NXVA 4KAKA 2FZJA 4KY8A 1D1GA 4PSYA 3GHWA 3SH2A 1DR5A 4PDJA 3N0HA 3IRMA 3S7AA 3HBBA 4KNEA 3FYVX 2D5NA 4FGGA 1BOZA 4KLXA 3CD2A 3EEMA 2CD2A 3F0VX 1IA3A 3NU0A 4KL9A 4Q0DA 3SRQX 3K45A 3FY9X 3KJRA 4NX6A 3OAFA 3NXTA 1RA9A 4HOEA 4DFRA 5HSRA 1RE7A 4GH8A 2DHFA 1VDRA 1DHFA 3HJ3A 1JUVA 3SA2A 4KJLA 1RX5A 4PSTA 5JG0X 3TQBA 3R33A 5HPBA 4XT6A 3QLSA 3NZAX 1E26A 3FREX 4LAHX 1QZFA 3E0BA 3RO9A 3M08A 1RX7A 3JSUA 4ELGA 3QLZA 4QI9A 5U27A 3FYWX 4EJ1A 5FDAA 4M6KA 1DYRA 1DF7A 3FQOA 3FRDX 3NZ9X 3JTWA 4IXFX 3FRBX 4G8ZX 1DR6A 3FQZA 3SRUX 3CL9A 1RF7A 3JWMA 3GI2A 4KJKA 3L3RA 4G3MA 3FL9A 4KBNA 3I8AX 3FQFA 3SGYA 2B3ZA 4QLFA 2C2SA 2W9TA 3QFXA 1DR7A 3QLXA 1RX1A 1JOLA 4EILA 2L28A 3JWKA 1S3WA 4P3QA 3IRNA 1DRHA 4X5FA 3KJSA 4HA7A 1MVTA 3ZPGA 4QHVA 1MVSA 3DRCA 1DHIA 1HFQA 5DFRA 2W9HA 3SRWX 4I1NA 1RX9A 1RA8A 5JA3A 2ITHA 4TU5X 1DR3A 4PSSA 2CIGA 1HFPA 3NXOA 3SRRX 1DG8A 3INVA 3K47A 1AI9A 4KM0A 6DFRA 1DREA 3F91A 1HFRA 2W9GA 4EIGA 2BLCA 3RG9A 2W3WA 4FGHA 4P3RA 3GHCA 3TQ8A 3FS6A 3Q1HA 3NXRA 3K74A 5U26A 3JWCA 1RD7A 3NZCX 1OHKA 1S3YA 3F8YA 3CSEA 3DAUA 3QL0A 2AZNA 4LAEX 2GD9A 4OR7A 4X5IA 5HVEA 4IXGX 3EEKA 1DR2A 4HOFA 4DPHA 1DRBA 1S3UA 1RH3A 5HI6A 4DP3A 4KFJA 4QJCA 2LF1A 1TDRA 3FQVA 2D0KA 5CC9A 3NZ6X 1DR1A 3SA1A 8DFRA 4ELBA 1RB3A 4X5GA 3F0SX 3IA5A 2BLAA 3IROA 5HVBA 3LG4A 3NTZA 3TQAA 1CZ3A 4QLEA 4ECKA 1RX2A 4M6LA 5HQYA 3UM8A 4QJZD 1DYJA 1DDRA 1DYHA 4KYAA 1RA1A 4M6JA 4X5JA 2INQA 3DG8A 4IXED 5E8QA 4XRBA 2ANOA 2FZIA 1RG7A 3QGTA 3DATA 4I13A 4QLGA 1DAJA
chains in the Genus database with same CATH superfamily
3DGAA 1AOEA 1S3VA 3DL5A 3D80A 4M2XA 3QG2A 2ANQA 5HF0X 3F0BX 4XT7A 4XECX 3K2HA 3GYFA 1DIUA 2W3MA 3DL6A 1RC4A 4DPDA 3IA4A 1RA3A 3NZBX 1DG5A 4M7UA 5HQZA 3EIGA 1KMVA 3SQYX 4ELEA 3M09A 3ROAA 1RB2A 2HQPA 3TQ9A 2W9SA 4XT8A 1M7AA 1U71A 2DRCA 4KJJA 3S3VA 4RGCA 3JVXA 3F8ZA 4FHBA 3EELA 1M79A 4LAGX 4X5HA 3EX8A 1RX8A 4KEBA 3OCHA 1M78A 3JW3A 5HSUA 1DLSA 3ZPCA 1PDBA 5HT4A 4DDRA 4H96A 3S9UA 1DYIA 2W3VA 3IX9A 3F0QX 3QLYA 4HOGA 3SAIA 3NXXA 4XE6X 1J3KA 1DDSA 1IA1A 1PD8A 3KFYA 2W3BA 3QYOA 4NX7A 1KLKA 2W3AA 1LY4A 1U72A 3D84X 2JYBA 1JOMA 4Q6AA 3FY8X 1AO8A 3NRRA 5ECXA 5HT5A 2HM9A 1RX6A 1IA4A 3JWFA 3FRAX 1LUDA 3FRFX 1DRFA 4XT5A 2KGKA 3SR5X 4OSGA 5EAJA 1DLRA 1DR4A 3QL3A 2ZZAA 4CD2A 4ELFA 5DXVA 1CD2A 1KMSA 4KD7A 4PTHA 4ELHA 1ZDRA 4Q67A 2XW7A 3FQCA 3EEJA 4EIZA 3NZDA 2QK8A 3F0UX 3UM6A 4M7VA 3QYLA 2BL9A 1DRAA 3UM5A 1OHJA 4XT4A 3NXYA 4P66A 1SEJA 3DFRA 1U70A 4P68A 3TD8A 3F0XX 3CLBA 5HF2X 3GHVA 3KGYA 3VCOA 5ECCA 1DHJA 4H97A 1VJ3A 2OBCA 7DFRA 3KY8A 4HA9A 4Q0EA 4G95A 1RA2A 1RX4A 1DG7A 4KM2A 1J3IA 2BLBA 2C2TA 3QLWA 2FZHA 1J3JA 4KY4A 1IA2A 4H95A 5HUIA 2G6VA 2H2QA 5CCCA 4PTJA 1PD9A 2O7PA 2OIPA 4LEKX 1BZFA 3FQ0A 1YHOA 3I3RA 1LY3A 3QLRA 1RX3A 3FL8A 3SRSX 2HXVA 3JW5A 2P4GA 4H98A 1DISA 3NXVA 4KAKA 2FZJA 4KY8A 1D1GA 4PSYA 3GHWA 3SH2A 1DR5A 4PDJA 3N0HA 3IRMA 3S7AA 3HBBA 4KNEA 3FYVX 2D5NA 4FGGA 1BOZA 4KLXA 3CD2A 3EEMA 2CD2A 3F0VX 1IA3A 3NU0A 4KL9A 4Q0DA 3SRQX 3K45A 3FY9X 3KJRA 4NX6A 3OAFA 3NXTA 1RA9A 4HOEA 4DFRA 5HSRA 1RE7A 4GH8A 2DHFA 1VDRA 1DHFA 3HJ3A 1JUVA 3SA2A 4KJLA 1RX5A 4PSTA 5JG0X 3TQBA 3R33A 5HPBA 4XT6A 3QLSA 3NZAX 1E26A 3FREX 4LAHX 1QZFA 3E0BA 3RO9A 3M08A 1RX7A 3JSUA 4ELGA 3QLZA 4QI9A 5U27A 3FYWX 4EJ1A 5FDAA 4M6KA 1DYRA 1DF7A 3FQOA 3FRDX 3NZ9X 3JTWA 4IXFX 3FRBX 4G8ZX 1DR6A 3FQZA 3SRUX 3CL9A 1RF7A 3JWMA 3GI2A 4KJKA 3L3RA 4G3MA 3FL9A 4KBNA 3I8AX 3FQFA 3SGYA 2B3ZA 4QLFA 2C2SA 2W9TA 3QFXA 1DR7A 3QLXA 1RX1A 1JOLA 4EILA 2L28A 3JWKA 1S3WA 4P3QA 3IRNA 1DRHA 4X5FA 3KJSA 4HA7A 1MVTA 3ZPGA 4QHVA 1MVSA 3DRCA 1DHIA 1HFQA 5DFRA 2W9HA 3SRWX 4I1NA 1RX9A 1RA8A 5JA3A 2ITHA 4TU5X 1DR3A 4PSSA 2CIGA 1HFPA 3NXOA 3SRRX 1DG8A 3INVA 3K47A 1AI9A 4KM0A 6DFRA 1DREA 3F91A 1HFRA 2W9GA 4EIGA 2BLCA 3RG9A 2W3WA 4FGHA 4P3RA 3GHCA 3TQ8A 3FS6A 3Q1HA 3NXRA 3K74A 5U26A 3JWCA 1RD7A 3NZCX 1OHKA 1S3YA 3F8YA 3CSEA 3DAUA 3QL0A 2AZNA 4LAEX 2GD9A 4OR7A 4X5IA 5HVEA 4IXGX 3EEKA 1DR2A 4HOFA 4DPHA 1DRBA 1S3UA 1RH3A 5HI6A 4DP3A 4KFJA 4QJCA 2LF1A 1TDRA 3FQVA 2D0KA 5CC9A 3NZ6X 1DR1A 3SA1A 8DFRA 4ELBA 1RB3A 4X5GA 3F0SX 3IA5A 2BLAA 3IROA 5HVBA 3LG4A 3NTZA 3TQAA 1CZ3A 4QLEA 4ECKA 1RX2A 4M6LA 5HQYA 3UM8A 4QJZD 1DYJA 1DDRA 1DYHA 4KYAA 1RA1A 4M6JA 4X5JA 2INQA 3DG8A 4IXED 5E8QA 4XRBA 2ANOA 2FZIA 1RG7A 3QGTA 3DATA 4I13A 4QLGA 1DAJA
chains in the Genus database with same CATH topology
3DGAA 1AOEA 1S3VA 3DL5A 3D80A 4M2XA 3QG2A 2ANQA 5HF0X 3F0BX 4XT7A 4XECX 3K2HA 3GYFA 1DIUA 2W3MA 3DL6A 1RC4A 4DPDA 3IA4A 1RA3A 3NZBX 1DG5A 4M7UA 5HQZA 3EIGA 1KMVA 3SQYX 4ELEA 3M09A 3ROAA 1RB2A 2HQPA 3TQ9A 2W9SA 4XT8A 1M7AA 1U71A 2DRCA 4KJJA 3S3VA 4RGCA 3JVXA 3F8ZA 4FHBA 3EELA 1M79A 4LAGX 4X5HA 3EX8A 1RX8A 4KEBA 3OCHA 1M78A 3JW3A 5HSUA 1DLSA 3ZPCA 1PDBA 5HT4A 4DDRA 4H96A 3S9UA 1DYIA 2W3VA 3IX9A 3F0QX 3QLYA 4HOGA 3SAIA 3NXXA 4XE6X 1J3KA 1DDSA 1IA1A 1PD8A 3KFYA 2W3BA 3QYOA 4NX7A 1KLKA 2W3AA 1LY4A 1U72A 3D84X 2JYBA 1JOMA 4Q6AA 3FY8X 1AO8A 3NRRA 5ECXA 5HT5A 2HM9A 1RX6A 1IA4A 3JWFA 3FRAX 1LUDA 3FRFX 1DRFA 4XT5A 2KGKA 3SR5X 4OSGA 5EAJA 1DLRA 1DR4A 3QL3A 2ZZAA 4CD2A 4ELFA 5DXVA 1CD2A 1KMSA 4KD7A 4PTHA 4ELHA 1ZDRA 4Q67A 2XW7A 3FQCA 3EEJA 4EIZA 3NZDA 2QK8A 3F0UX 3UM6A 4M7VA 3QYLA 2BL9A 1DRAA 3UM5A 1OHJA 4XT4A 3NXYA 4P66A 1SEJA 3DFRA 1U70A 4P68A 3TD8A 3F0XX 3CLBA 5HF2X 3GHVA 3KGYA 3VCOA 5ECCA 1DHJA 4H97A 1VJ3A 2OBCA 7DFRA 3KY8A 4HA9A 4Q0EA 4G95A 1RA2A 1RX4A 1DG7A 4KM2A 1J3IA 2BLBA 2C2TA 3QLWA 2FZHA 1J3JA 4KY4A 1IA2A 4H95A 5HUIA 2G6VA 2H2QA 5CCCA 4PTJA 1PD9A 2O7PA 2OIPA 4LEKX 1BZFA 3FQ0A 1YHOA 3I3RA 1LY3A 3QLRA 1RX3A 3FL8A 3SRSX 2HXVA 3JW5A 2P4GA 4H98A 1DISA 3NXVA 4KAKA 2FZJA 4KY8A 1D1GA 4PSYA 3GHWA 3SH2A 1DR5A 4PDJA 3N0HA 3IRMA 3S7AA 3HBBA 4KNEA 3FYVX 2D5NA 4FGGA 1BOZA 4KLXA 3CD2A 3EEMA 2CD2A 3F0VX 1IA3A 3NU0A 4KL9A 4Q0DA 3SRQX 3K45A 3FY9X 3KJRA 4NX6A 3OAFA 3NXTA 1RA9A 4HOEA 4DFRA 5HSRA 1RE7A 4GH8A 2DHFA 1VDRA 1DHFA 3HJ3A 1JUVA 3SA2A 4KJLA 1RX5A 4PSTA 5JG0X 3TQBA 3R33A 5HPBA 4XT6A 3QLSA 3NZAX 1E26A 3FREX 4LAHX 1QZFA 3E0BA 3RO9A 3M08A 1RX7A 3JSUA 4ELGA 3QLZA 4QI9A 5U27A 3FYWX 4EJ1A 5FDAA 4M6KA 1DYRA 1DF7A 3FQOA 3FRDX 3NZ9X 3JTWA 4IXFX 3FRBX 4G8ZX 1DR6A 3FQZA 3SRUX 3CL9A 1RF7A 3JWMA 3GI2A 4KJKA 3L3RA 4G3MA 3FL9A 4KBNA 3I8AX 3FQFA 3SGYA 2B3ZA 4QLFA 2C2SA 2W9TA 3QFXA 1DR7A 3QLXA 1RX1A 1JOLA 4EILA 2L28A 3JWKA 1S3WA 4P3QA 3IRNA 1DRHA 4X5FA 3KJSA 4HA7A 1MVTA 3ZPGA 4QHVA 1MVSA 3DRCA 1DHIA 1HFQA 5DFRA 2W9HA 3SRWX 4I1NA 1RX9A 1RA8A 5JA3A 2ITHA 4TU5X 1DR3A 4PSSA 2CIGA 1HFPA 3NXOA 3SRRX 1DG8A 3INVA 3K47A 1AI9A 4KM0A 6DFRA 1DREA 3F91A 1HFRA 2W9GA 4EIGA 2BLCA 3RG9A 2W3WA 4FGHA 4P3RA 3GHCA 3TQ8A 3FS6A 3Q1HA 3NXRA 3K74A 5U26A 3JWCA 1RD7A 3NZCX 1OHKA 1S3YA 3F8YA 3CSEA 3DAUA 3QL0A 2AZNA 4LAEX 2GD9A 4OR7A 4X5IA 5HVEA 4IXGX 3EEKA 1DR2A 4HOFA 4DPHA 1DRBA 1S3UA 1RH3A 5HI6A 4DP3A 4KFJA 4QJCA 2LF1A 1TDRA 3FQVA 2D0KA 5CC9A 3NZ6X 1DR1A 3SA1A 8DFRA 4ELBA 1RB3A 4X5GA 3F0SX 3IA5A 2BLAA 3IROA 5HVBA 3LG4A 3NTZA 3TQAA 1CZ3A 4QLEA 4ECKA 1RX2A 4M6LA 5HQYA 3UM8A 4QJZD 1DYJA 1DDRA 1DYHA 4KYAA 1RA1A 4M6JA 4X5JA 2INQA 3DG8A 4IXED 5E8QA 4XRBA 2ANOA 2FZIA 1RG7A 3QGTA 3DATA 4I13A 4QLGA 1DAJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DGA A;  1AOE A;  1S3V A;  3DL5 A;  3D80 A;  4M2X A;  3QG2 A;  2ANQ A;  5HF0 X;  3F0B X;  4XT7 A;  4XEC X;  3K2H A;  3GYF A;  1DIU A;  2W3M A;  3DL6 A;  1RC4 A;  4DPD A;  3IA4 A;  1RA3 A;  3NZB X;  1DG5 A;  4M7U A;  5HQZ A;  3EIG A;  1KMV A;  3SQY X;  4ELE A;  3M09 A;  3ROA A;  1RB2 A;  2HQP A;  3TQ9 A;  2W9S A;  4XT8 A;  1M7A A;  1U71 A;  2DRC A;  4KJJ A;  3S3V A;  4RGC A;  3JVX A;  3F8Z A;  4FHB A;  3EEL A;  1M79 A;  4LAG X;  4X5H A;  3EX8 A;  1RX8 A;  4KEB A;  3OCH A;  1M78 A;  3JW3 A;  5HSU A;  1DLS A;  3ZPC A;  1PDB A;  5HT4 A;  4DDR A;  4H96 A;  3S9U A;  1DYI A;  2W3V A;  3IX9 A;  3F0Q X;  3QLY A;  4HOG A;  3SAI A;  3NXX A;  4XE6 X;  1J3K A;  1DDS A;  1IA1 A;  1PD8 A;  3KFY A;  2W3B A;  3QYO A;  4NX7 A;  1KLK A;  2W3A A;  1LY4 A;  1U72 A;  3D84 X;  2JYB A;  1JOM A;  4Q6A A;  3FY8 X;  1AO8 A;  3NRR A;  5ECX A;  5HT5 A;  2HM9 A;  1RX6 A;  1IA4 A;  3JWF A;  3FRA X;  1LUD A;  3FRF X;  1DRF A;  4XT5 A;  2KGK A;  3SR5 X;  4OSG A;  5EAJ A;  1DLR A;  1DR4 A;  3QL3 A;  2ZZA A;  4CD2 A;  4ELF A;  5DXV A;  1CD2 A;  1KMS A;  4KD7 A;  4PTH A;  4ELH A;  1ZDR A;  4Q67 A;  2XW7 A;  3FQC A;  3EEJ A;  4EIZ A;  3NZD A;  2QK8 A;  3F0U X;  3UM6 A;  4M7V A;  3QYL A;  2BL9 A;  1DRA A;  3UM5 A;  1OHJ A;  4XT4 A;  3NXY A;  4P66 A;  1SEJ A;  3DFR A;  1U70 A;  4P68 A;  3TD8 A;  3F0X X;  3CLB A;  5HF2 X;  3GHV A;  3KGY A;  3VCO A;  5ECC A;  1DHJ A;  4H97 A;  1VJ3 A;  2OBC A;  7DFR A;  3KY8 A;  4HA9 A;  4Q0E A;  4G95 A;  1RA2 A;  1RX4 A;  1DG7 A;  4KM2 A;  1J3I A;  2BLB A;  2C2T A;  3QLW A;  2FZH A;  1J3J A;  4KY4 A;  1IA2 A;  4H95 A;  5HUI A;  2G6V A;  2H2Q A;  5CCC A;  4PTJ A;  1PD9 A;  2O7P A;  2OIP A;  4LEK X;  1BZF A;  3FQ0 A;  1YHO A;  3I3R A;  1LY3 A;  3QLR A;  1RX3 A;  3FL8 A;  3SRS X;  2HXV A;  3JW5 A;  2P4G A;  4H98 A;  1DIS A;  3NXV A;  4KAK A;  2FZJ A;  4KY8 A;  1D1G A;  4PSY A;  3GHW A;  3SH2 A;  1DR5 A;  4PDJ A;  3N0H A;  3IRM A;  3S7A A;  3HBB A;  4KNE A;  3FYV X;  2D5N A;  4FGG A;  1BOZ A;  4KLX A;  3CD2 A;  3EEM A;  2CD2 A;  3F0V X;  1IA3 A;  3NU0 A;  4KL9 A;  4Q0D A;  3SRQ X;  3K45 A;  3FY9 X;  3KJR A;  4NX6 A;  3OAF A;  3NXT A;  1RA9 A;  4HOE A;  4DFR A;  5HSR A;  1RE7 A;  4GH8 A;  2DHF A;  1VDR A;  1DHF A;  3HJ3 A;  1JUV A;  3SA2 A;  4KJL A;  1RX5 A;  4PST A;  5JG0 X;  3TQB A;  3R33 A;  5HPB A;  4XT6 A;  3QLS A;  3NZA X;  1E26 A;  3FRE X;  4LAH X;  1QZF A;  3E0B A;  3RO9 A;  3M08 A;  1RX7 A;  3JSU A;  4ELG A;  3QLZ A;  4QI9 A;  5U27 A;  3FYW X;  4EJ1 A;  5FDA A;  4M6K A;  1DYR A;  1DF7 A;  3FQO A;  3FRD X;  3NZ9 X;  3JTW A;  4IXF X;  3FRB X;  4G8Z X;  1DR6 A;  3FQZ A;  3SRU X;  3CL9 A;  1RF7 A;  3JWM A;  3GI2 A;  4KJK A;  3L3R A;  4G3M A;  3FL9 A;  4KBN A;  3I8A X;  3FQF A;  3SGY A;  2B3Z A;  4QLF A;  2C2S A;  2W9T A;  3QFX A;  1DR7 A;  3QLX A;  1RX1 A;  1JOL A;  4EIL A;  2L28 A;  3JWK A;  1S3W A;  4P3Q A;  3IRN A;  1DRH A;  4X5F A;  3KJS A;  4HA7 A;  1MVT A;  3ZPG A;  4QHV A;  1MVS A;  3DRC A;  1DHI A;  1HFQ A;  5DFR A;  2W9H A;  3SRW X;  4I1N A;  1RX9 A;  1RA8 A;  5JA3 A;  2ITH A;  4TU5 X;  1DR3 A;  4PSS A;  2CIG A;  1HFP A;  3NXO A;  3SRR X;  1DG8 A;  3INV A;  3K47 A;  1AI9 A;  4KM0 A;  6DFR A;  1DRE A;  3F91 A;  1HFR A;  2W9G A;  4EIG A;  2BLC A;  3RG9 A;  2W3W A;  4FGH A;  4P3R A;  3GHC A;  3TQ8 A;  3FS6 A;  3Q1H A;  3NXR A;  3K74 A;  5U26 A;  3JWC A;  1RD7 A;  3NZC X;  1OHK A;  1S3Y A;  3F8Y A;  3CSE A;  3DAU A;  3QL0 A;  2AZN A;  4LAE X;  2GD9 A;  4OR7 A;  4X5I A;  5HVE A;  4IXG X;  3EEK A;  1DR2 A;  4HOF A;  4DPH A;  1DRB A;  1S3U A;  1RH3 A;  5HI6 A;  4DP3 A;  4KFJ A;  4QJC A;  2LF1 A;  1TDR A;  3FQV A;  2D0K A;  5CC9 A;  3NZ6 X;  1DR1 A;  3SA1 A;  8DFR A;  4ELB A;  1RB3 A;  4X5G A;  3F0S X;  3IA5 A;  2BLA A;  3IRO A;  5HVB A;  3LG4 A;  3NTZ A;  3TQA A;  1CZ3 A;  4QLE A;  4ECK A;  1RX2 A;  4M6L A;  5HQY A;  3UM8 A;  4QJZ D;  1DYJ A;  1DDR A;  1DYH A;  4KYA A;  1RA1 A;  4M6J A;  4X5J A;  2INQ A;  3DG8 A;  4IXE D;  5E8Q A;  4XRB A;  2ANO A;  2FZI A;  1RG7 A;  3QGT A;  3DAT A;  4I13 A;  4QLG A;  1DAJ A; 
#chains in the Genus database with same CATH topology
 3DGA A;  1AOE A;  1S3V A;  3DL5 A;  3D80 A;  4M2X A;  3QG2 A;  2ANQ A;  5HF0 X;  3F0B X;  4XT7 A;  4XEC X;  3K2H A;  3GYF A;  1DIU A;  2W3M A;  3DL6 A;  1RC4 A;  4DPD A;  3IA4 A;  1RA3 A;  3NZB X;  1DG5 A;  4M7U A;  5HQZ A;  3EIG A;  1KMV A;  3SQY X;  4ELE A;  3M09 A;  3ROA A;  1RB2 A;  2HQP A;  3TQ9 A;  2W9S A;  4XT8 A;  1M7A A;  1U71 A;  2DRC A;  4KJJ A;  3S3V A;  4RGC A;  3JVX A;  3F8Z A;  4FHB A;  3EEL A;  1M79 A;  4LAG X;  4X5H A;  3EX8 A;  1RX8 A;  4KEB A;  3OCH A;  1M78 A;  3JW3 A;  5HSU A;  1DLS A;  3ZPC A;  1PDB A;  5HT4 A;  4DDR A;  4H96 A;  3S9U A;  1DYI A;  2W3V A;  3IX9 A;  3F0Q X;  3QLY A;  4HOG A;  3SAI A;  3NXX A;  4XE6 X;  1J3K A;  1DDS A;  1IA1 A;  1PD8 A;  3KFY A;  2W3B A;  3QYO A;  4NX7 A;  1KLK A;  2W3A A;  1LY4 A;  1U72 A;  3D84 X;  2JYB A;  1JOM A;  4Q6A A;  3FY8 X;  1AO8 A;  3NRR A;  5ECX A;  5HT5 A;  2HM9 A;  1RX6 A;  1IA4 A;  3JWF A;  3FRA X;  1LUD A;  3FRF X;  1DRF A;  4XT5 A;  2KGK A;  3SR5 X;  4OSG A;  5EAJ A;  1DLR A;  1DR4 A;  3QL3 A;  2ZZA A;  4CD2 A;  4ELF A;  5DXV A;  1CD2 A;  1KMS A;  4KD7 A;  4PTH A;  4ELH A;  1ZDR A;  4Q67 A;  2XW7 A;  3FQC A;  3EEJ A;  4EIZ A;  3NZD A;  2QK8 A;  3F0U X;  3UM6 A;  4M7V A;  3QYL A;  2BL9 A;  1DRA A;  3UM5 A;  1OHJ A;  4XT4 A;  3NXY A;  4P66 A;  1SEJ A;  3DFR A;  1U70 A;  4P68 A;  3TD8 A;  3F0X X;  3CLB A;  5HF2 X;  3GHV A;  3KGY A;  3VCO A;  5ECC A;  1DHJ A;  4H97 A;  1VJ3 A;  2OBC A;  7DFR A;  3KY8 A;  4HA9 A;  4Q0E A;  4G95 A;  1RA2 A;  1RX4 A;  1DG7 A;  4KM2 A;  1J3I A;  2BLB A;  2C2T A;  3QLW A;  2FZH A;  1J3J A;  4KY4 A;  1IA2 A;  4H95 A;  5HUI A;  2G6V A;  2H2Q A;  5CCC A;  4PTJ A;  1PD9 A;  2O7P A;  2OIP A;  4LEK X;  1BZF A;  3FQ0 A;  1YHO A;  3I3R A;  1LY3 A;  3QLR A;  1RX3 A;  3FL8 A;  3SRS X;  2HXV A;  3JW5 A;  2P4G A;  4H98 A;  1DIS A;  3NXV A;  4KAK A;  2FZJ A;  4KY8 A;  1D1G A;  4PSY A;  3GHW A;  3SH2 A;  1DR5 A;  4PDJ A;  3N0H A;  3IRM A;  3S7A A;  3HBB A;  4KNE A;  3FYV X;  2D5N A;  4FGG A;  1BOZ A;  4KLX A;  3CD2 A;  3EEM A;  2CD2 A;  3F0V X;  1IA3 A;  3NU0 A;  4KL9 A;  4Q0D A;  3SRQ X;  3K45 A;  3FY9 X;  3KJR A;  4NX6 A;  3OAF A;  3NXT A;  1RA9 A;  4HOE A;  4DFR A;  5HSR A;  1RE7 A;  4GH8 A;  2DHF A;  1VDR A;  1DHF A;  3HJ3 A;  1JUV A;  3SA2 A;  4KJL A;  1RX5 A;  4PST A;  5JG0 X;  3TQB A;  3R33 A;  5HPB A;  4XT6 A;  3QLS A;  3NZA X;  1E26 A;  3FRE X;  4LAH X;  1QZF A;  3E0B A;  3RO9 A;  3M08 A;  1RX7 A;  3JSU A;  4ELG A;  3QLZ A;  4QI9 A;  5U27 A;  3FYW X;  4EJ1 A;  5FDA A;  4M6K A;  1DYR A;  1DF7 A;  3FQO A;  3FRD X;  3NZ9 X;  3JTW A;  4IXF X;  3FRB X;  4G8Z X;  1DR6 A;  3FQZ A;  3SRU X;  3CL9 A;  1RF7 A;  3JWM A;  3GI2 A;  4KJK A;  3L3R A;  4G3M A;  3FL9 A;  4KBN A;  3I8A X;  3FQF A;  3SGY A;  2B3Z A;  4QLF A;  2C2S A;  2W9T A;  3QFX A;  1DR7 A;  3QLX A;  1RX1 A;  1JOL A;  4EIL A;  2L28 A;  3JWK A;  1S3W A;  4P3Q A;  3IRN A;  1DRH A;  4X5F A;  3KJS A;  4HA7 A;  1MVT A;  3ZPG A;  4QHV A;  1MVS A;  3DRC A;  1DHI A;  1HFQ A;  5DFR A;  2W9H A;  3SRW X;  4I1N A;  1RX9 A;  1RA8 A;  5JA3 A;  2ITH A;  4TU5 X;  1DR3 A;  4PSS A;  2CIG A;  1HFP A;  3NXO A;  3SRR X;  1DG8 A;  3INV A;  3K47 A;  1AI9 A;  4KM0 A;  6DFR A;  1DRE A;  3F91 A;  1HFR A;  2W9G A;  4EIG A;  2BLC A;  3RG9 A;  2W3W A;  4FGH A;  4P3R A;  3GHC A;  3TQ8 A;  3FS6 A;  3Q1H A;  3NXR A;  3K74 A;  5U26 A;  3JWC A;  1RD7 A;  3NZC X;  1OHK A;  1S3Y A;  3F8Y A;  3CSE A;  3DAU A;  3QL0 A;  2AZN A;  4LAE X;  2GD9 A;  4OR7 A;  4X5I A;  5HVE A;  4IXG X;  3EEK A;  1DR2 A;  4HOF A;  4DPH A;  1DRB A;  1S3U A;  1RH3 A;  5HI6 A;  4DP3 A;  4KFJ A;  4QJC A;  2LF1 A;  1TDR A;  3FQV A;  2D0K A;  5CC9 A;  3NZ6 X;  1DR1 A;  3SA1 A;  8DFR A;  4ELB A;  1RB3 A;  4X5G A;  3F0S X;  3IA5 A;  2BLA A;  3IRO A;  5HVB A;  3LG4 A;  3NTZ A;  3TQA A;  1CZ3 A;  4QLE A;  4ECK A;  1RX2 A;  4M6L A;  5HQY A;  3UM8 A;  4QJZ D;  1DYJ A;  1DDR A;  1DYH A;  4KYA A;  1RA1 A;  4M6J A;  4X5J A;  2INQ A;  3DG8 A;  4IXE D;  5E8Q A;  4XRB A;  2ANO A;  2FZI A;  1RG7 A;  3QGT A;  3DAT A;  4I13 A;  4QLG A;  1DAJ A; 
#chains in the Genus database with same CATH homology
 3DGA A;  1AOE A;  1S3V A;  3DL5 A;  3D80 A;  4M2X A;  3QG2 A;  2ANQ A;  5HF0 X;  3F0B X;  4XT7 A;  4XEC X;  3K2H A;  3GYF A;  1DIU A;  2W3M A;  3DL6 A;  1RC4 A;  4DPD A;  3IA4 A;  1RA3 A;  3NZB X;  1DG5 A;  4M7U A;  5HQZ A;  3EIG A;  1KMV A;  3SQY X;  4ELE A;  3M09 A;  3ROA A;  1RB2 A;  2HQP A;  3TQ9 A;  2W9S A;  4XT8 A;  1M7A A;  1U71 A;  2DRC A;  4KJJ A;  3S3V A;  4RGC A;  3JVX A;  3F8Z A;  4FHB A;  3EEL A;  1M79 A;  4LAG X;  4X5H A;  3EX8 A;  1RX8 A;  4KEB A;  3OCH A;  1M78 A;  3JW3 A;  5HSU A;  1DLS A;  3ZPC A;  1PDB A;  5HT4 A;  4DDR A;  4H96 A;  3S9U A;  1DYI A;  2W3V A;  3IX9 A;  3F0Q X;  3QLY A;  4HOG A;  3SAI A;  3NXX A;  4XE6 X;  1J3K A;  1DDS A;  1IA1 A;  1PD8 A;  3KFY A;  2W3B A;  3QYO A;  4NX7 A;  1KLK A;  2W3A A;  1LY4 A;  1U72 A;  3D84 X;  2JYB A;  1JOM A;  4Q6A A;  3FY8 X;  1AO8 A;  3NRR A;  5ECX A;  5HT5 A;  2HM9 A;  1RX6 A;  1IA4 A;  3JWF A;  3FRA X;  1LUD A;  3FRF X;  1DRF A;  4XT5 A;  2KGK A;  3SR5 X;  4OSG A;  5EAJ A;  1DLR A;  1DR4 A;  3QL3 A;  2ZZA A;  4CD2 A;  4ELF A;  5DXV A;  1CD2 A;  1KMS A;  4KD7 A;  4PTH A;  4ELH A;  1ZDR A;  4Q67 A;  2XW7 A;  3FQC A;  3EEJ A;  4EIZ A;  3NZD A;  2QK8 A;  3F0U X;  3UM6 A;  4M7V A;  3QYL A;  2BL9 A;  1DRA A;  3UM5 A;  1OHJ A;  4XT4 A;  3NXY A;  4P66 A;  1SEJ A;  3DFR A;  1U70 A;  4P68 A;  3TD8 A;  3F0X X;  3CLB A;  5HF2 X;  3GHV A;  3KGY A;  3VCO A;  5ECC A;  1DHJ A;  4H97 A;  1VJ3 A;  2OBC A;  7DFR A;  3KY8 A;  4HA9 A;  4Q0E A;  4G95 A;  1RA2 A;  1RX4 A;  1DG7 A;  4KM2 A;  1J3I A;  2BLB A;  2C2T A;  3QLW A;  2FZH A;  1J3J A;  4KY4 A;  1IA2 A;  4H95 A;  5HUI A;  2G6V A;  2H2Q A;  5CCC A;  4PTJ A;  1PD9 A;  2O7P A;  2OIP A;  4LEK X;  1BZF A;  3FQ0 A;  1YHO A;  3I3R A;  1LY3 A;  3QLR A;  1RX3 A;  3FL8 A;  3SRS X;  2HXV A;  3JW5 A;  2P4G A;  4H98 A;  1DIS A;  3NXV A;  4KAK A;  2FZJ A;  4KY8 A;  1D1G A;  4PSY A;  3GHW A;  3SH2 A;  1DR5 A;  4PDJ A;  3N0H A;  3IRM A;  3S7A A;  3HBB A;  4KNE A;  3FYV X;  2D5N A;  4FGG A;  1BOZ A;  4KLX A;  3CD2 A;  3EEM A;  2CD2 A;  3F0V X;  1IA3 A;  3NU0 A;  4KL9 A;  4Q0D A;  3SRQ X;  3K45 A;  3FY9 X;  3KJR A;  4NX6 A;  3OAF A;  3NXT A;  1RA9 A;  4HOE A;  4DFR A;  5HSR A;  1RE7 A;  4GH8 A;  2DHF A;  1VDR A;  1DHF A;  3HJ3 A;  1JUV A;  3SA2 A;  4KJL A;  1RX5 A;  4PST A;  5JG0 X;  3TQB A;  3R33 A;  5HPB A;  4XT6 A;  3QLS A;  3NZA X;  1E26 A;  3FRE X;  4LAH X;  1QZF A;  3E0B A;  3RO9 A;  3M08 A;  1RX7 A;  3JSU A;  4ELG A;  3QLZ A;  4QI9 A;  5U27 A;  3FYW X;  4EJ1 A;  5FDA A;  4M6K A;  1DYR A;  1DF7 A;  3FQO A;  3FRD X;  3NZ9 X;  3JTW A;  4IXF X;  3FRB X;  4G8Z X;  1DR6 A;  3FQZ A;  3SRU X;  3CL9 A;  1RF7 A;  3JWM A;  3GI2 A;  4KJK A;  3L3R A;  4G3M A;  3FL9 A;  4KBN A;  3I8A X;  3FQF A;  3SGY A;  2B3Z A;  4QLF A;  2C2S A;  2W9T A;  3QFX A;  1DR7 A;  3QLX A;  1RX1 A;  1JOL A;  4EIL A;  2L28 A;  3JWK A;  1S3W A;  4P3Q A;  3IRN A;  1DRH A;  4X5F A;  3KJS A;  4HA7 A;  1MVT A;  3ZPG A;  4QHV A;  1MVS A;  3DRC A;  1DHI A;  1HFQ A;  5DFR A;  2W9H A;  3SRW X;  4I1N A;  1RX9 A;  1RA8 A;  5JA3 A;  2ITH A;  4TU5 X;  1DR3 A;  4PSS A;  2CIG A;  1HFP A;  3NXO A;  3SRR X;  1DG8 A;  3INV A;  3K47 A;  1AI9 A;  4KM0 A;  6DFR A;  1DRE A;  3F91 A;  1HFR A;  2W9G A;  4EIG A;  2BLC A;  3RG9 A;  2W3W A;  4FGH A;  4P3R A;  3GHC A;  3TQ8 A;  3FS6 A;  3Q1H A;  3NXR A;  3K74 A;  5U26 A;  3JWC A;  1RD7 A;  3NZC X;  1OHK A;  1S3Y A;  3F8Y A;  3CSE A;  3DAU A;  3QL0 A;  2AZN A;  4LAE X;  2GD9 A;  4OR7 A;  4X5I A;  5HVE A;  4IXG X;  3EEK A;  1DR2 A;  4HOF A;  4DPH A;  1DRB A;  1S3U A;  1RH3 A;  5HI6 A;  4DP3 A;  4KFJ A;  4QJC A;  2LF1 A;  1TDR A;  3FQV A;  2D0K A;  5CC9 A;  3NZ6 X;  1DR1 A;  3SA1 A;  8DFR A;  4ELB A;  1RB3 A;  4X5G A;  3F0S X;  3IA5 A;  2BLA A;  3IRO A;  5HVB A;  3LG4 A;  3NTZ A;  3TQA A;  1CZ3 A;  4QLE A;  4ECK A;  1RX2 A;  4M6L A;  5HQY A;  3UM8 A;  4QJZ D;  1DYJ A;  1DDR A;  1DYH A;  4KYA A;  1RA1 A;  4M6J A;  4X5J A;  2INQ A;  3DG8 A;  4IXE D;  5E8Q A;  4XRB A;  2ANO A;  2FZI A;  1RG7 A;  3QGT A;  3DAT A;  4I13 A;  4QLG A;  1DAJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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