1U70A

Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrofolate reductase
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
186
structure length
186
Chain Sequence
VRPLNCIVAVSQNMGIGKNGDRPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Mus musculus
molecule keywords Dihydrofolate reductase
total genus 48
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2004-08-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1u70A00
3D80A 4KJLA 3NXXA 4KD7A 1RB2A 4M6LA 3F0QX 3FY9X 4G8ZX 3DATA 2D5NA 4KJKA 3NXYA 4EILA 3GHVA 1LUDA 4ECKA 5FDAA 1D1GA 1CD2A 1DG5A 1DYJA 3IA5A 4KBNA 3M08A 4KYAA 1JUVA 4XT6A 3EELA 2FZIA 2HQPA 4QLGA 3QYLA 1RA8A 5DXVA 2KGKA 1PD9A 1RE7A 3SR5X 4NX6A 3JWMA 5DFRA 4XE6X 2ZZAA 3DG8A 3F0BX 4Q6AA 4HOGA 2ANOA 1IA4A 1QZFA 4NX7A 3ROAA 1LY4A 2HM9A 2LF1A 3QLSA 5HF0X 3FQFA 3FY8X 2JYBA 1YHOA 3CLBA 3QLYA 4Q0EA 1J3KA 4TU5X 1M78A 6DFRA 3CL9A 3FRAX 1RG7A 3JW3A 4KL9A 1DHIA 3EEJA 2XW7A 1RH3A 4X5GA 3SRRX 3JWCA 1IA3A 4XECX 3FQVA 1RX9A 4G95A 1J3IA 3HJ3A 2W3VA 4LEKX 4KY4A 2BLCA 3QGTA 1RX7A 2W9TA 1RX2A 3GHCA 3I8AX 4QJZD 5HSUA 3NZDA 3ZPGA 3INVA 1RA2A 3CD2A 4IXGX 2ITHA 3QLZA 4KM2A 1CZ3A 4QI9A 4P66A 4OR7A 3LG4A 3TD8A 4LAGX 3JSUA 1M79A 3QLRA 2HXVA 4Q67A 4KEBA 1S3YA 4PDJA 4LAHX 3SGYA 3UM5A 3ZPCA 1JOLA 3SRWX 2C2SA 3SRQX 3E0BA 3KJSA 1DF7A 3IA4A 5HUIA 3F0UX 3SRUX 1S3UA 4EIZA 1RX4A 2BLAA 1TDRA 4GH8A 4DFRA 1U70A 3FRBX 4G3MA 3FL9A 1HFQA 4M6KA 3JWKA 4X5IA 3N0HA 3DL6A 4HA9A 4DP3A 2W9HA 1VDRA 3QLXA 5ECCA 3S7AA 1DIUA 3F91A 1HFRA 1DHJA 4M7UA 1DR4A 4QHVA 3NZ6X 1DHFA 3QYOA 4XT8A 3JWFA 4XT7A 3D84X 4P3RA 4M7VA 1E26A 1DG7A 4H95A 3KJRA 2D0KA 3OCHA 1DR1A 1RA9A 4KJJA 1RA3A 2FZHA 4XRBA 4QLFA 1DYHA 3K47A 3QL3A 2DRCA 3NRRA 1KMSA 5E8QA 4Q0DA 1DRHA 1DR3A 2BL9A 1DG8A 3FS6A 1DLSA 4RGCA 3KFYA 2W9GA 2C2TA 2W3AA 3NZBX 1MVTA 3SA2A 1IA2A 3S9UA 3S3VA 3SAIA 3NXVA 3RG9A 3TQBA 1DRAA 1U71A 1AO8A 3JW5A 5HVBA 1RX6A 4HOEA 4HA7A 4ELEA 4OSGA 3SRSX 3IROA 2INQA 5HSRA 3SA1A 4X5HA 3FQ0A 2L28A 1AI9A 5HT5A 4PSTA 3F0SX 3Q1HA 1S3VA 3IX9A 5ECXA 3FQOA 4KY8A 3RO9A 1MVSA 3FL8A 1DRBA 1RC4A 3NZCX 4PTHA 1VJ3A 2BLBA 3DAUA 4PSYA 5JA3A 1M7AA 4KFJA 1DR5A 3QG2A 5U26A 4M2XA 3DFRA 3EIGA 3IRNA 2W3WA 5EAJA 3F8ZA 4ELBA 3TQ9A 5HQYA 3EEKA 3K45A 1RX3A 4KAKA 1DAJA 3M09A 3DGAA 1KLKA 5HI6A 1DR7A 2B3ZA 1OHKA 4KLXA 1RD7A 1RB3A 2FZJA 5HQZA 4CD2A 1RX1A 2G6VA 2W9SA 4ELGA 3TQAA 1DREA 1AOEA 4IXED 5HPBA 2O7PA 4LAEX 2H2QA 1DYIA 4P3QA 3DRCA 1S3WA 3EX8A 3QL0A 4FHBA 4DPHA 3F8YA 4I1NA 3F0VX 3NXTA 7DFRA 3IRMA 1OHJA 4FGHA 3UM6A 4ELFA 3NZ9X 1PD8A 3R33A 3NU0A 4DDRA 3KGYA 2OBCA 3UM8A 1DRFA 3QLWA 4FGGA 4ELHA 3HBBA 3FQZA 1DDRA 3K2HA 3GYFA 1LY3A 3FYWX 4H96A 5CCCA 1RX8A 3I3RA 3VCOA 3DL5A 1BZFA 4XT4A 3OAFA 4PSSA 5U27A 3JTWA 4EIGA 2W3MA 2GD9A 3QFXA 2QK8A 2OIPA 3FRFX 1J3JA 1JOMA 4I13A 1DR6A 1HFPA 4X5FA 2DHFA 1PDBA 3NTZA 1KMVA 3FQCA 3NZAX 1RA1A 4XT5A 3FYVX 5HVEA 1DDSA 4X5JA 1DISA 4DPDA 1U72A 3NXOA 1DLRA 3FRDX 3KY8A 3K74A 4KM0A 1IA1A 5JG0X 2AZNA 4M6JA 3FREX 3F0XX 2P4GA 4H98A 1DYRA 2CIGA 1DR2A 4P68A 3GHWA 4QJCA 4IXFX 1RX5A 2CD2A 4KNEA 1ZDRA 2W3BA 1RF7A 5HT4A 3SH2A 5CC9A 3EEMA 3SQYX 4H97A 8DFRA 3L3RA 5HF2X 4PTJA 3JVXA 3TQ8A 3GI2A 2ANQA 4EJ1A 1SEJA 4QLEA 1BOZA 3CSEA 3NXRA 4HOFA
chains in the Genus database with same CATH superfamily
3D80A 4KJLA 3NXXA 4KD7A 1RB2A 4M6LA 3F0QX 3FY9X 4G8ZX 3DATA 2D5NA 4KJKA 3NXYA 4EILA 3GHVA 1LUDA 4ECKA 5FDAA 1D1GA 1CD2A 1DG5A 1DYJA 3IA5A 4KBNA 3M08A 4KYAA 1JUVA 4XT6A 3EELA 2FZIA 2HQPA 4QLGA 3QYLA 1RA8A 5DXVA 2KGKA 1PD9A 1RE7A 3SR5X 4NX6A 3JWMA 5DFRA 4XE6X 2ZZAA 3DG8A 3F0BX 4Q6AA 4HOGA 2ANOA 1IA4A 1QZFA 4NX7A 3ROAA 1LY4A 2HM9A 2LF1A 3QLSA 5HF0X 3FQFA 3FY8X 2JYBA 1YHOA 3CLBA 3QLYA 4Q0EA 1J3KA 4TU5X 1M78A 6DFRA 3CL9A 3FRAX 1RG7A 3JW3A 4KL9A 1DHIA 3EEJA 2XW7A 1RH3A 4X5GA 3SRRX 3JWCA 1IA3A 4XECX 3FQVA 1RX9A 4G95A 1J3IA 3HJ3A 2W3VA 4LEKX 4KY4A 2BLCA 3QGTA 1RX7A 2W9TA 1RX2A 3GHCA 3I8AX 4QJZD 5HSUA 3NZDA 3ZPGA 3INVA 1RA2A 3CD2A 4IXGX 2ITHA 3QLZA 4KM2A 1CZ3A 4QI9A 4P66A 4OR7A 3LG4A 3TD8A 4LAGX 3JSUA 1M79A 3QLRA 2HXVA 4Q67A 4KEBA 1S3YA 4PDJA 4LAHX 3SGYA 3UM5A 3ZPCA 1JOLA 3SRWX 2C2SA 3SRQX 3E0BA 3KJSA 1DF7A 3IA4A 5HUIA 3F0UX 3SRUX 1S3UA 4EIZA 1RX4A 2BLAA 1TDRA 4GH8A 4DFRA 1U70A 3FRBX 4G3MA 3FL9A 1HFQA 4M6KA 3JWKA 4X5IA 3N0HA 3DL6A 4HA9A 4DP3A 2W9HA 1VDRA 3QLXA 5ECCA 3S7AA 1DIUA 3F91A 1HFRA 1DHJA 4M7UA 1DR4A 4QHVA 3NZ6X 1DHFA 3QYOA 4XT8A 3JWFA 4XT7A 3D84X 4P3RA 4M7VA 1E26A 1DG7A 4H95A 3KJRA 2D0KA 3OCHA 1DR1A 1RA9A 4KJJA 1RA3A 2FZHA 4XRBA 4QLFA 1DYHA 3K47A 3QL3A 2DRCA 3NRRA 1KMSA 5E8QA 4Q0DA 1DRHA 1DR3A 2BL9A 1DG8A 3FS6A 1DLSA 4RGCA 3KFYA 2W9GA 2C2TA 2W3AA 3NZBX 1MVTA 3SA2A 1IA2A 3S9UA 3S3VA 3SAIA 3NXVA 3RG9A 3TQBA 1DRAA 1U71A 1AO8A 3JW5A 5HVBA 1RX6A 4HOEA 4HA7A 4ELEA 4OSGA 3SRSX 3IROA 2INQA 5HSRA 3SA1A 4X5HA 3FQ0A 2L28A 1AI9A 5HT5A 4PSTA 3F0SX 3Q1HA 1S3VA 3IX9A 5ECXA 3FQOA 4KY8A 3RO9A 1MVSA 3FL8A 1DRBA 1RC4A 3NZCX 4PTHA 1VJ3A 2BLBA 3DAUA 4PSYA 5JA3A 1M7AA 4KFJA 1DR5A 3QG2A 5U26A 4M2XA 3DFRA 3EIGA 3IRNA 2W3WA 5EAJA 3F8ZA 4ELBA 3TQ9A 5HQYA 3EEKA 3K45A 1RX3A 4KAKA 1DAJA 3M09A 3DGAA 1KLKA 5HI6A 1DR7A 2B3ZA 1OHKA 4KLXA 1RD7A 1RB3A 2FZJA 5HQZA 4CD2A 1RX1A 2G6VA 2W9SA 4ELGA 3TQAA 1DREA 1AOEA 4IXED 5HPBA 2O7PA 4LAEX 2H2QA 1DYIA 4P3QA 3DRCA 1S3WA 3EX8A 3QL0A 4FHBA 4DPHA 3F8YA 4I1NA 3F0VX 3NXTA 7DFRA 3IRMA 1OHJA 4FGHA 3UM6A 4ELFA 3NZ9X 1PD8A 3R33A 3NU0A 4DDRA 3KGYA 2OBCA 3UM8A 1DRFA 3QLWA 4FGGA 4ELHA 3HBBA 3FQZA 1DDRA 3K2HA 3GYFA 1LY3A 3FYWX 4H96A 5CCCA 1RX8A 3I3RA 3VCOA 3DL5A 1BZFA 4XT4A 3OAFA 4PSSA 5U27A 3JTWA 4EIGA 2W3MA 2GD9A 3QFXA 2QK8A 2OIPA 3FRFX 1J3JA 1JOMA 4I13A 1DR6A 1HFPA 4X5FA 2DHFA 1PDBA 3NTZA 1KMVA 3FQCA 3NZAX 1RA1A 4XT5A 3FYVX 5HVEA 1DDSA 4X5JA 1DISA 4DPDA 1U72A 3NXOA 1DLRA 3FRDX 3KY8A 3K74A 4KM0A 1IA1A 5JG0X 2AZNA 4M6JA 3FREX 3F0XX 2P4GA 4H98A 1DYRA 2CIGA 1DR2A 4P68A 3GHWA 4QJCA 4IXFX 1RX5A 2CD2A 4KNEA 1ZDRA 2W3BA 1RF7A 5HT4A 3SH2A 5CC9A 3EEMA 3SQYX 4H97A 8DFRA 3L3RA 5HF2X 4PTJA 3JVXA 3TQ8A 3GI2A 2ANQA 4EJ1A 1SEJA 4QLEA 1BOZA 3CSEA 3NXRA 4HOFA
chains in the Genus database with same CATH topology
3D80A 4KJLA 3NXXA 4KD7A 1RB2A 4M6LA 3F0QX 3FY9X 4G8ZX 3DATA 2D5NA 4KJKA 3NXYA 4EILA 3GHVA 1LUDA 4ECKA 5FDAA 1D1GA 1CD2A 1DG5A 1DYJA 3IA5A 4KBNA 3M08A 4KYAA 1JUVA 4XT6A 3EELA 2FZIA 2HQPA 4QLGA 3QYLA 1RA8A 5DXVA 2KGKA 1PD9A 1RE7A 3SR5X 4NX6A 3JWMA 5DFRA 4XE6X 2ZZAA 3DG8A 3F0BX 4Q6AA 4HOGA 2ANOA 1IA4A 1QZFA 4NX7A 3ROAA 1LY4A 2HM9A 2LF1A 3QLSA 5HF0X 3FQFA 3FY8X 2JYBA 1YHOA 3CLBA 3QLYA 4Q0EA 1J3KA 4TU5X 1M78A 6DFRA 3CL9A 3FRAX 1RG7A 3JW3A 4KL9A 1DHIA 3EEJA 2XW7A 1RH3A 4X5GA 3SRRX 3JWCA 1IA3A 4XECX 3FQVA 1RX9A 4G95A 1J3IA 3HJ3A 2W3VA 4LEKX 4KY4A 2BLCA 3QGTA 1RX7A 2W9TA 1RX2A 3GHCA 3I8AX 4QJZD 5HSUA 3NZDA 3ZPGA 3INVA 1RA2A 3CD2A 4IXGX 2ITHA 3QLZA 4KM2A 1CZ3A 4QI9A 4P66A 4OR7A 3LG4A 3TD8A 4LAGX 3JSUA 1M79A 3QLRA 2HXVA 4Q67A 4KEBA 1S3YA 4PDJA 4LAHX 3SGYA 3UM5A 3ZPCA 1JOLA 3SRWX 2C2SA 3SRQX 3E0BA 3KJSA 1DF7A 3IA4A 5HUIA 3F0UX 3SRUX 1S3UA 4EIZA 1RX4A 2BLAA 1TDRA 4GH8A 4DFRA 1U70A 3FRBX 4G3MA 3FL9A 1HFQA 4M6KA 3JWKA 4X5IA 3N0HA 3DL6A 4HA9A 4DP3A 2W9HA 1VDRA 3QLXA 5ECCA 3S7AA 1DIUA 3F91A 1HFRA 1DHJA 4M7UA 1DR4A 4QHVA 3NZ6X 1DHFA 3QYOA 4XT8A 3JWFA 4XT7A 3D84X 4P3RA 4M7VA 1E26A 1DG7A 4H95A 3KJRA 2D0KA 3OCHA 1DR1A 1RA9A 4KJJA 1RA3A 2FZHA 4XRBA 4QLFA 1DYHA 3K47A 3QL3A 2DRCA 3NRRA 1KMSA 5E8QA 4Q0DA 1DRHA 1DR3A 2BL9A 1DG8A 3FS6A 1DLSA 4RGCA 3KFYA 2W9GA 2C2TA 2W3AA 3NZBX 1MVTA 3SA2A 1IA2A 3S9UA 3S3VA 3SAIA 3NXVA 3RG9A 3TQBA 1DRAA 1U71A 1AO8A 3JW5A 5HVBA 1RX6A 4HOEA 4HA7A 4ELEA 4OSGA 3SRSX 3IROA 2INQA 5HSRA 3SA1A 4X5HA 3FQ0A 2L28A 1AI9A 5HT5A 4PSTA 3F0SX 3Q1HA 1S3VA 3IX9A 5ECXA 3FQOA 4KY8A 3RO9A 1MVSA 3FL8A 1DRBA 1RC4A 3NZCX 4PTHA 1VJ3A 2BLBA 3DAUA 4PSYA 5JA3A 1M7AA 4KFJA 1DR5A 3QG2A 5U26A 4M2XA 3DFRA 3EIGA 3IRNA 2W3WA 5EAJA 3F8ZA 4ELBA 3TQ9A 5HQYA 3EEKA 3K45A 1RX3A 4KAKA 1DAJA 3M09A 3DGAA 1KLKA 5HI6A 1DR7A 2B3ZA 1OHKA 4KLXA 1RD7A 1RB3A 2FZJA 5HQZA 4CD2A 1RX1A 2G6VA 2W9SA 4ELGA 3TQAA 1DREA 1AOEA 4IXED 5HPBA 2O7PA 4LAEX 2H2QA 1DYIA 4P3QA 3DRCA 1S3WA 3EX8A 3QL0A 4FHBA 4DPHA 3F8YA 4I1NA 3F0VX 3NXTA 7DFRA 3IRMA 1OHJA 4FGHA 3UM6A 4ELFA 3NZ9X 1PD8A 3R33A 3NU0A 4DDRA 3KGYA 2OBCA 3UM8A 1DRFA 3QLWA 4FGGA 4ELHA 3HBBA 3FQZA 1DDRA 3K2HA 3GYFA 1LY3A 3FYWX 4H96A 5CCCA 1RX8A 3I3RA 3VCOA 3DL5A 1BZFA 4XT4A 3OAFA 4PSSA 5U27A 3JTWA 4EIGA 2W3MA 2GD9A 3QFXA 2QK8A 2OIPA 3FRFX 1J3JA 1JOMA 4I13A 1DR6A 1HFPA 4X5FA 2DHFA 1PDBA 3NTZA 1KMVA 3FQCA 3NZAX 1RA1A 4XT5A 3FYVX 5HVEA 1DDSA 4X5JA 1DISA 4DPDA 1U72A 3NXOA 1DLRA 3FRDX 3KY8A 3K74A 4KM0A 1IA1A 5JG0X 2AZNA 4M6JA 3FREX 3F0XX 2P4GA 4H98A 1DYRA 2CIGA 1DR2A 4P68A 3GHWA 4QJCA 4IXFX 1RX5A 2CD2A 4KNEA 1ZDRA 2W3BA 1RF7A 5HT4A 3SH2A 5CC9A 3EEMA 3SQYX 4H97A 8DFRA 3L3RA 5HF2X 4PTJA 3JVXA 3TQ8A 3GI2A 2ANQA 4EJ1A 1SEJA 4QLEA 1BOZA 3CSEA 3NXRA 4HOFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3D80 A;  4KJL A;  3NXX A;  4KD7 A;  1RB2 A;  4M6L A;  3F0Q X;  3FY9 X;  4G8Z X;  3DAT A;  2D5N A;  4KJK A;  3NXY A;  4EIL A;  3GHV A;  1LUD A;  4ECK A;  5FDA A;  1D1G A;  1CD2 A;  1DG5 A;  1DYJ A;  3IA5 A;  4KBN A;  3M08 A;  4KYA A;  1JUV A;  4XT6 A;  3EEL A;  2FZI A;  2HQP A;  4QLG A;  3QYL A;  1RA8 A;  5DXV A;  2KGK A;  1PD9 A;  1RE7 A;  3SR5 X;  4NX6 A;  3JWM A;  5DFR A;  4XE6 X;  2ZZA A;  3DG8 A;  3F0B X;  4Q6A A;  4HOG A;  2ANO A;  1IA4 A;  1QZF A;  4NX7 A;  3ROA A;  1LY4 A;  2HM9 A;  2LF1 A;  3QLS A;  5HF0 X;  3FQF A;  3FY8 X;  2JYB A;  1YHO A;  3CLB A;  3QLY A;  4Q0E A;  1J3K A;  4TU5 X;  1M78 A;  6DFR A;  3CL9 A;  3FRA X;  1RG7 A;  3JW3 A;  4KL9 A;  1DHI A;  3EEJ A;  2XW7 A;  1RH3 A;  4X5G A;  3SRR X;  3JWC A;  1IA3 A;  4XEC X;  3FQV A;  1RX9 A;  4G95 A;  1J3I A;  3HJ3 A;  2W3V A;  4LEK X;  4KY4 A;  2BLC A;  3QGT A;  1RX7 A;  2W9T A;  1RX2 A;  3GHC A;  3I8A X;  4QJZ D;  5HSU A;  3NZD A;  3ZPG A;  3INV A;  1RA2 A;  3CD2 A;  4IXG X;  2ITH A;  3QLZ A;  4KM2 A;  1CZ3 A;  4QI9 A;  4P66 A;  4OR7 A;  3LG4 A;  3TD8 A;  4LAG X;  3JSU A;  1M79 A;  3QLR A;  2HXV A;  4Q67 A;  4KEB A;  1S3Y A;  4PDJ A;  4LAH X;  3SGY A;  3UM5 A;  3ZPC A;  1JOL A;  3SRW X;  2C2S A;  3SRQ X;  3E0B A;  3KJS A;  1DF7 A;  3IA4 A;  5HUI A;  3F0U X;  3SRU X;  1S3U A;  4EIZ A;  1RX4 A;  2BLA A;  1TDR A;  4GH8 A;  4DFR A;  1U70 A;  3FRB X;  4G3M A;  3FL9 A;  1HFQ A;  4M6K A;  3JWK A;  4X5I A;  3N0H A;  3DL6 A;  4HA9 A;  4DP3 A;  2W9H A;  1VDR A;  3QLX A;  5ECC A;  3S7A A;  1DIU A;  3F91 A;  1HFR A;  1DHJ A;  4M7U A;  1DR4 A;  4QHV A;  3NZ6 X;  1DHF A;  3QYO A;  4XT8 A;  3JWF A;  4XT7 A;  3D84 X;  4P3R A;  4M7V A;  1E26 A;  1DG7 A;  4H95 A;  3KJR A;  2D0K A;  3OCH A;  1DR1 A;  1RA9 A;  4KJJ A;  1RA3 A;  2FZH A;  4XRB A;  4QLF A;  1DYH A;  3K47 A;  3QL3 A;  2DRC A;  3NRR A;  1KMS A;  5E8Q A;  4Q0D A;  1DRH A;  1DR3 A;  2BL9 A;  1DG8 A;  3FS6 A;  1DLS A;  4RGC A;  3KFY A;  2W9G A;  2C2T A;  2W3A A;  3NZB X;  1MVT A;  3SA2 A;  1IA2 A;  3S9U A;  3S3V A;  3SAI A;  3NXV A;  3RG9 A;  3TQB A;  1DRA A;  1U71 A;  1AO8 A;  3JW5 A;  5HVB A;  1RX6 A;  4HOE A;  4HA7 A;  4ELE A;  4OSG A;  3SRS X;  3IRO A;  2INQ A;  5HSR A;  3SA1 A;  4X5H A;  3FQ0 A;  2L28 A;  1AI9 A;  5HT5 A;  4PST A;  3F0S X;  3Q1H A;  1S3V A;  3IX9 A;  5ECX A;  3FQO A;  4KY8 A;  3RO9 A;  1MVS A;  3FL8 A;  1DRB A;  1RC4 A;  3NZC X;  4PTH A;  1VJ3 A;  2BLB A;  3DAU A;  4PSY A;  5JA3 A;  1M7A A;  4KFJ A;  1DR5 A;  3QG2 A;  5U26 A;  4M2X A;  3DFR A;  3EIG A;  3IRN A;  2W3W A;  5EAJ A;  3F8Z A;  4ELB A;  3TQ9 A;  5HQY A;  3EEK A;  3K45 A;  1RX3 A;  4KAK A;  1DAJ A;  3M09 A;  3DGA A;  1KLK A;  5HI6 A;  1DR7 A;  2B3Z A;  1OHK A;  4KLX A;  1RD7 A;  1RB3 A;  2FZJ A;  5HQZ A;  4CD2 A;  1RX1 A;  2G6V A;  2W9S A;  4ELG A;  3TQA A;  1DRE A;  1AOE A;  4IXE D;  5HPB A;  2O7P A;  4LAE X;  2H2Q A;  1DYI A;  4P3Q A;  3DRC A;  1S3W A;  3EX8 A;  3QL0 A;  4FHB A;  4DPH A;  3F8Y A;  4I1N A;  3F0V X;  3NXT A;  7DFR A;  3IRM A;  1OHJ A;  4FGH A;  3UM6 A;  4ELF A;  3NZ9 X;  1PD8 A;  3R33 A;  3NU0 A;  4DDR A;  3KGY A;  2OBC A;  3UM8 A;  1DRF A;  3QLW A;  4FGG A;  4ELH A;  3HBB A;  3FQZ A;  1DDR A;  3K2H A;  3GYF A;  1LY3 A;  3FYW X;  4H96 A;  5CCC A;  1RX8 A;  3I3R A;  3VCO A;  3DL5 A;  1BZF A;  4XT4 A;  3OAF A;  4PSS A;  5U27 A;  3JTW A;  4EIG A;  2W3M A;  2GD9 A;  3QFX A;  2QK8 A;  2OIP A;  3FRF X;  1J3J A;  1JOM A;  4I13 A;  1DR6 A;  1HFP A;  4X5F A;  2DHF A;  1PDB A;  3NTZ A;  1KMV A;  3FQC A;  3NZA X;  1RA1 A;  4XT5 A;  3FYV X;  5HVE A;  1DDS A;  4X5J A;  1DIS A;  4DPD A;  1U72 A;  3NXO A;  1DLR A;  3FRD X;  3KY8 A;  3K74 A;  4KM0 A;  1IA1 A;  5JG0 X;  2AZN A;  4M6J A;  3FRE X;  3F0X X;  2P4G A;  4H98 A;  1DYR A;  2CIG A;  1DR2 A;  4P68 A;  3GHW A;  4QJC A;  4IXF X;  1RX5 A;  2CD2 A;  4KNE A;  1ZDR A;  2W3B A;  1RF7 A;  5HT4 A;  3SH2 A;  5CC9 A;  3EEM A;  3SQY X;  4H97 A;  8DFR A;  3L3R A;  5HF2 X;  4PTJ A;  3JVX A;  3TQ8 A;  3GI2 A;  2ANQ A;  4EJ1 A;  1SEJ A;  4QLE A;  1BOZ A;  3CSE A;  3NXR A;  4HOF A; 
#chains in the Genus database with same CATH topology
 3D80 A;  4KJL A;  3NXX A;  4KD7 A;  1RB2 A;  4M6L A;  3F0Q X;  3FY9 X;  4G8Z X;  3DAT A;  2D5N A;  4KJK A;  3NXY A;  4EIL A;  3GHV A;  1LUD A;  4ECK A;  5FDA A;  1D1G A;  1CD2 A;  1DG5 A;  1DYJ A;  3IA5 A;  4KBN A;  3M08 A;  4KYA A;  1JUV A;  4XT6 A;  3EEL A;  2FZI A;  2HQP A;  4QLG A;  3QYL A;  1RA8 A;  5DXV A;  2KGK A;  1PD9 A;  1RE7 A;  3SR5 X;  4NX6 A;  3JWM A;  5DFR A;  4XE6 X;  2ZZA A;  3DG8 A;  3F0B X;  4Q6A A;  4HOG A;  2ANO A;  1IA4 A;  1QZF A;  4NX7 A;  3ROA A;  1LY4 A;  2HM9 A;  2LF1 A;  3QLS A;  5HF0 X;  3FQF A;  3FY8 X;  2JYB A;  1YHO A;  3CLB A;  3QLY A;  4Q0E A;  1J3K A;  4TU5 X;  1M78 A;  6DFR A;  3CL9 A;  3FRA X;  1RG7 A;  3JW3 A;  4KL9 A;  1DHI A;  3EEJ A;  2XW7 A;  1RH3 A;  4X5G A;  3SRR X;  3JWC A;  1IA3 A;  4XEC X;  3FQV A;  1RX9 A;  4G95 A;  1J3I A;  3HJ3 A;  2W3V A;  4LEK X;  4KY4 A;  2BLC A;  3QGT A;  1RX7 A;  2W9T A;  1RX2 A;  3GHC A;  3I8A X;  4QJZ D;  5HSU A;  3NZD A;  3ZPG A;  3INV A;  1RA2 A;  3CD2 A;  4IXG X;  2ITH A;  3QLZ A;  4KM2 A;  1CZ3 A;  4QI9 A;  4P66 A;  4OR7 A;  3LG4 A;  3TD8 A;  4LAG X;  3JSU A;  1M79 A;  3QLR A;  2HXV A;  4Q67 A;  4KEB A;  1S3Y A;  4PDJ A;  4LAH X;  3SGY A;  3UM5 A;  3ZPC A;  1JOL A;  3SRW X;  2C2S A;  3SRQ X;  3E0B A;  3KJS A;  1DF7 A;  3IA4 A;  5HUI A;  3F0U X;  3SRU X;  1S3U A;  4EIZ A;  1RX4 A;  2BLA A;  1TDR A;  4GH8 A;  4DFR A;  1U70 A;  3FRB X;  4G3M A;  3FL9 A;  1HFQ A;  4M6K A;  3JWK A;  4X5I A;  3N0H A;  3DL6 A;  4HA9 A;  4DP3 A;  2W9H A;  1VDR A;  3QLX A;  5ECC A;  3S7A A;  1DIU A;  3F91 A;  1HFR A;  1DHJ A;  4M7U A;  1DR4 A;  4QHV A;  3NZ6 X;  1DHF A;  3QYO A;  4XT8 A;  3JWF A;  4XT7 A;  3D84 X;  4P3R A;  4M7V A;  1E26 A;  1DG7 A;  4H95 A;  3KJR A;  2D0K A;  3OCH A;  1DR1 A;  1RA9 A;  4KJJ A;  1RA3 A;  2FZH A;  4XRB A;  4QLF A;  1DYH A;  3K47 A;  3QL3 A;  2DRC A;  3NRR A;  1KMS A;  5E8Q A;  4Q0D A;  1DRH A;  1DR3 A;  2BL9 A;  1DG8 A;  3FS6 A;  1DLS A;  4RGC A;  3KFY A;  2W9G A;  2C2T A;  2W3A A;  3NZB X;  1MVT A;  3SA2 A;  1IA2 A;  3S9U A;  3S3V A;  3SAI A;  3NXV A;  3RG9 A;  3TQB A;  1DRA A;  1U71 A;  1AO8 A;  3JW5 A;  5HVB A;  1RX6 A;  4HOE A;  4HA7 A;  4ELE A;  4OSG A;  3SRS X;  3IRO A;  2INQ A;  5HSR A;  3SA1 A;  4X5H A;  3FQ0 A;  2L28 A;  1AI9 A;  5HT5 A;  4PST A;  3F0S X;  3Q1H A;  1S3V A;  3IX9 A;  5ECX A;  3FQO A;  4KY8 A;  3RO9 A;  1MVS A;  3FL8 A;  1DRB A;  1RC4 A;  3NZC X;  4PTH A;  1VJ3 A;  2BLB A;  3DAU A;  4PSY A;  5JA3 A;  1M7A A;  4KFJ A;  1DR5 A;  3QG2 A;  5U26 A;  4M2X A;  3DFR A;  3EIG A;  3IRN A;  2W3W A;  5EAJ A;  3F8Z A;  4ELB A;  3TQ9 A;  5HQY A;  3EEK A;  3K45 A;  1RX3 A;  4KAK A;  1DAJ A;  3M09 A;  3DGA A;  1KLK A;  5HI6 A;  1DR7 A;  2B3Z A;  1OHK A;  4KLX A;  1RD7 A;  1RB3 A;  2FZJ A;  5HQZ A;  4CD2 A;  1RX1 A;  2G6V A;  2W9S A;  4ELG A;  3TQA A;  1DRE A;  1AOE A;  4IXE D;  5HPB A;  2O7P A;  4LAE X;  2H2Q A;  1DYI A;  4P3Q A;  3DRC A;  1S3W A;  3EX8 A;  3QL0 A;  4FHB A;  4DPH A;  3F8Y A;  4I1N A;  3F0V X;  3NXT A;  7DFR A;  3IRM A;  1OHJ A;  4FGH A;  3UM6 A;  4ELF A;  3NZ9 X;  1PD8 A;  3R33 A;  3NU0 A;  4DDR A;  3KGY A;  2OBC A;  3UM8 A;  1DRF A;  3QLW A;  4FGG A;  4ELH A;  3HBB A;  3FQZ A;  1DDR A;  3K2H A;  3GYF A;  1LY3 A;  3FYW X;  4H96 A;  5CCC A;  1RX8 A;  3I3R A;  3VCO A;  3DL5 A;  1BZF A;  4XT4 A;  3OAF A;  4PSS A;  5U27 A;  3JTW A;  4EIG A;  2W3M A;  2GD9 A;  3QFX A;  2QK8 A;  2OIP A;  3FRF X;  1J3J A;  1JOM A;  4I13 A;  1DR6 A;  1HFP A;  4X5F A;  2DHF A;  1PDB A;  3NTZ A;  1KMV A;  3FQC A;  3NZA X;  1RA1 A;  4XT5 A;  3FYV X;  5HVE A;  1DDS A;  4X5J A;  1DIS A;  4DPD A;  1U72 A;  3NXO A;  1DLR A;  3FRD X;  3KY8 A;  3K74 A;  4KM0 A;  1IA1 A;  5JG0 X;  2AZN A;  4M6J A;  3FRE X;  3F0X X;  2P4G A;  4H98 A;  1DYR A;  2CIG A;  1DR2 A;  4P68 A;  3GHW A;  4QJC A;  4IXF X;  1RX5 A;  2CD2 A;  4KNE A;  1ZDR A;  2W3B A;  1RF7 A;  5HT4 A;  3SH2 A;  5CC9 A;  3EEM A;  3SQY X;  4H97 A;  8DFR A;  3L3R A;  5HF2 X;  4PTJ A;  3JVX A;  3TQ8 A;  3GI2 A;  2ANQ A;  4EJ1 A;  1SEJ A;  4QLE A;  1BOZ A;  3CSE A;  3NXR A;  4HOF A; 
#chains in the Genus database with same CATH homology
 3D80 A;  4KJL A;  3NXX A;  4KD7 A;  1RB2 A;  4M6L A;  3F0Q X;  3FY9 X;  4G8Z X;  3DAT A;  2D5N A;  4KJK A;  3NXY A;  4EIL A;  3GHV A;  1LUD A;  4ECK A;  5FDA A;  1D1G A;  1CD2 A;  1DG5 A;  1DYJ A;  3IA5 A;  4KBN A;  3M08 A;  4KYA A;  1JUV A;  4XT6 A;  3EEL A;  2FZI A;  2HQP A;  4QLG A;  3QYL A;  1RA8 A;  5DXV A;  2KGK A;  1PD9 A;  1RE7 A;  3SR5 X;  4NX6 A;  3JWM A;  5DFR A;  4XE6 X;  2ZZA A;  3DG8 A;  3F0B X;  4Q6A A;  4HOG A;  2ANO A;  1IA4 A;  1QZF A;  4NX7 A;  3ROA A;  1LY4 A;  2HM9 A;  2LF1 A;  3QLS A;  5HF0 X;  3FQF A;  3FY8 X;  2JYB A;  1YHO A;  3CLB A;  3QLY A;  4Q0E A;  1J3K A;  4TU5 X;  1M78 A;  6DFR A;  3CL9 A;  3FRA X;  1RG7 A;  3JW3 A;  4KL9 A;  1DHI A;  3EEJ A;  2XW7 A;  1RH3 A;  4X5G A;  3SRR X;  3JWC A;  1IA3 A;  4XEC X;  3FQV A;  1RX9 A;  4G95 A;  1J3I A;  3HJ3 A;  2W3V A;  4LEK X;  4KY4 A;  2BLC A;  3QGT A;  1RX7 A;  2W9T A;  1RX2 A;  3GHC A;  3I8A X;  4QJZ D;  5HSU A;  3NZD A;  3ZPG A;  3INV A;  1RA2 A;  3CD2 A;  4IXG X;  2ITH A;  3QLZ A;  4KM2 A;  1CZ3 A;  4QI9 A;  4P66 A;  4OR7 A;  3LG4 A;  3TD8 A;  4LAG X;  3JSU A;  1M79 A;  3QLR A;  2HXV A;  4Q67 A;  4KEB A;  1S3Y A;  4PDJ A;  4LAH X;  3SGY A;  3UM5 A;  3ZPC A;  1JOL A;  3SRW X;  2C2S A;  3SRQ X;  3E0B A;  3KJS A;  1DF7 A;  3IA4 A;  5HUI A;  3F0U X;  3SRU X;  1S3U A;  4EIZ A;  1RX4 A;  2BLA A;  1TDR A;  4GH8 A;  4DFR A;  1U70 A;  3FRB X;  4G3M A;  3FL9 A;  1HFQ A;  4M6K A;  3JWK A;  4X5I A;  3N0H A;  3DL6 A;  4HA9 A;  4DP3 A;  2W9H A;  1VDR A;  3QLX A;  5ECC A;  3S7A A;  1DIU A;  3F91 A;  1HFR A;  1DHJ A;  4M7U A;  1DR4 A;  4QHV A;  3NZ6 X;  1DHF A;  3QYO A;  4XT8 A;  3JWF A;  4XT7 A;  3D84 X;  4P3R A;  4M7V A;  1E26 A;  1DG7 A;  4H95 A;  3KJR A;  2D0K A;  3OCH A;  1DR1 A;  1RA9 A;  4KJJ A;  1RA3 A;  2FZH A;  4XRB A;  4QLF A;  1DYH A;  3K47 A;  3QL3 A;  2DRC A;  3NRR A;  1KMS A;  5E8Q A;  4Q0D A;  1DRH A;  1DR3 A;  2BL9 A;  1DG8 A;  3FS6 A;  1DLS A;  4RGC A;  3KFY A;  2W9G A;  2C2T A;  2W3A A;  3NZB X;  1MVT A;  3SA2 A;  1IA2 A;  3S9U A;  3S3V A;  3SAI A;  3NXV A;  3RG9 A;  3TQB A;  1DRA A;  1U71 A;  1AO8 A;  3JW5 A;  5HVB A;  1RX6 A;  4HOE A;  4HA7 A;  4ELE A;  4OSG A;  3SRS X;  3IRO A;  2INQ A;  5HSR A;  3SA1 A;  4X5H A;  3FQ0 A;  2L28 A;  1AI9 A;  5HT5 A;  4PST A;  3F0S X;  3Q1H A;  1S3V A;  3IX9 A;  5ECX A;  3FQO A;  4KY8 A;  3RO9 A;  1MVS A;  3FL8 A;  1DRB A;  1RC4 A;  3NZC X;  4PTH A;  1VJ3 A;  2BLB A;  3DAU A;  4PSY A;  5JA3 A;  1M7A A;  4KFJ A;  1DR5 A;  3QG2 A;  5U26 A;  4M2X A;  3DFR A;  3EIG A;  3IRN A;  2W3W A;  5EAJ A;  3F8Z A;  4ELB A;  3TQ9 A;  5HQY A;  3EEK A;  3K45 A;  1RX3 A;  4KAK A;  1DAJ A;  3M09 A;  3DGA A;  1KLK A;  5HI6 A;  1DR7 A;  2B3Z A;  1OHK A;  4KLX A;  1RD7 A;  1RB3 A;  2FZJ A;  5HQZ A;  4CD2 A;  1RX1 A;  2G6V A;  2W9S A;  4ELG A;  3TQA A;  1DRE A;  1AOE A;  4IXE D;  5HPB A;  2O7P A;  4LAE X;  2H2Q A;  1DYI A;  4P3Q A;  3DRC A;  1S3W A;  3EX8 A;  3QL0 A;  4FHB A;  4DPH A;  3F8Y A;  4I1N A;  3F0V X;  3NXT A;  7DFR A;  3IRM A;  1OHJ A;  4FGH A;  3UM6 A;  4ELF A;  3NZ9 X;  1PD8 A;  3R33 A;  3NU0 A;  4DDR A;  3KGY A;  2OBC A;  3UM8 A;  1DRF A;  3QLW A;  4FGG A;  4ELH A;  3HBB A;  3FQZ A;  1DDR A;  3K2H A;  3GYF A;  1LY3 A;  3FYW X;  4H96 A;  5CCC A;  1RX8 A;  3I3R A;  3VCO A;  3DL5 A;  1BZF A;  4XT4 A;  3OAF A;  4PSS A;  5U27 A;  3JTW A;  4EIG A;  2W3M A;  2GD9 A;  3QFX A;  2QK8 A;  2OIP A;  3FRF X;  1J3J A;  1JOM A;  4I13 A;  1DR6 A;  1HFP A;  4X5F A;  2DHF A;  1PDB A;  3NTZ A;  1KMV A;  3FQC A;  3NZA X;  1RA1 A;  4XT5 A;  3FYV X;  5HVE A;  1DDS A;  4X5J A;  1DIS A;  4DPD A;  1U72 A;  3NXO A;  1DLR A;  3FRD X;  3KY8 A;  3K74 A;  4KM0 A;  1IA1 A;  5JG0 X;  2AZN A;  4M6J A;  3FRE X;  3F0X X;  2P4G A;  4H98 A;  1DYR A;  2CIG A;  1DR2 A;  4P68 A;  3GHW A;  4QJC A;  4IXF X;  1RX5 A;  2CD2 A;  4KNE A;  1ZDR A;  2W3B A;  1RF7 A;  5HT4 A;  3SH2 A;  5CC9 A;  3EEM A;  3SQY X;  4H97 A;  8DFR A;  3L3R A;  5HF2 X;  4PTJ A;  3JVX A;  3TQ8 A;  3GI2 A;  2ANQ A;  4EJ1 A;  1SEJ A;  4QLE A;  1BOZ A;  3CSE A;  3NXR A;  4HOF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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