1U72A

Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrfolate reductase ternary crystal complexes with methotrexate and nadph
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 48
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2004-08-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1u72A00
4Q0EA 1ZDRA 5CCCA 2C2SA 3GYFA 4HA7A 1VJ3A 2OBCA 5FDAA 5HUIA 1RG7A 4Q6AA 3QLYA 3HJ3A 2BLCA 2W3WA 2OIPA 3E0BA 3UM6A 4DPDA 2H2QA 1KLKA 3JVXA 2ITHA 1SEJA 2FZHA 4KLXA 1TDRA 4PSSA 4P66A 1AO8A 4DFRA 1RX1A 3SQYX 1QZFA 5HVBA 4G95A 4GH8A 3S7AA 1LY4A 3IA4A 5HVEA 1RX9A 3FYWX 3FL9A 5HT5A 3NXXA 1DR4A 2INQA 1IA1A 4HOEA 3EEKA 3QLSA 3QLXA 3OCHA 3IA5A 1S3WA 1DHJA 1DHFA 1VDRA 4Q0DA 3HBBA 5E8QA 4M6JA 1DG7A 3SAIA 2AZNA 3EEJA 1DLSA 4KJJA 3KGYA 5HQZA 3ZPCA 4PSYA 5JA3A 4PTJA 4HOGA 5HSRA 3K45A 3JSUA 5ECCA 2JYBA 3F8YA 2BLBA 3QYOA 1PD9A 3QFXA 1RB2A 4HA9A 4LAHX 3JTWA 7DFRA 1MVSA 3DFRA 3D84X 2KGKA 2C2TA 2BLAA 3FQFA 3EEMA 3F0XX 4XECX 3FS6A 5HPBA 4FHBA 4P68A 3SRQX 4ELGA 4DPHA 4I1NA 3VCOA 3M08A 1M79A 3FQZA 4KY8A 1DYIA 1RX3A 2D5NA 3EELA 3NXTA 2ZZAA 4KY4A 4I13A 4ECKA 1RA8A 3TD8A 3UM5A 3NXVA 4ELEA 4XE6X 1DHIA 3I8AX 3EIGA 3D80A 3SRUX 3GHWA 3FY9X 4NX7A 3FQVA 4X5IA 2LF1A 5U26A 2HXVA 2W3AA 2FZJA 3NU0A 3ROAA 1CZ3A 3KFYA 2BL9A 4OSGA 1DIUA 3EX8A 1J3IA 3K74A 1RE7A 3JWCA 5HT4A 3TQAA 4X5FA 4EJ1A 4KL9A 3SH2A 3NZ9X 3INVA 4QLGA 1PD8A 2HQPA 4QHVA 3DG8A 3KY8A 2G6VA 3TQBA 3FQ0A 4ELHA 4M2XA 4XT7A 4P3RA 1J3JA 3F0BX 1DR7A 3GHVA 5DXVA 2W9TA 3ZPGA 1M78A 3CSEA 1DRFA 3RG9A 2ANOA 2FZIA 3QL3A 3QLRA 1RB3A 1DR5A 3QYLA 4LEKX 1JOMA 5CC9A 3I3RA 3QL0A 3NTZA 1CD2A 3CD2A 1IA2A 2L28A 3OAFA 4KEBA 2DHFA 1S3VA 2W3MA 4EIZA 1RX2A 4FGHA 4H95A 1D1GA 3FYVX 3F0UX 4X5HA 4QLEA 1RD7A 3N0HA 1YHOA 3NZCX 4CD2A 5HF0X 3NZAX 3RO9A 3TQ9A 2B3ZA 4X5GA 5DFRA 1M7AA 3DL6A 4QI9A 3SR5X 3JW3A 3TQ8A 1DR3A 3LG4A 1DAJA 3SA1A 3CL9A 2D0KA 3CLBA 4IXFX 5U27A 2W9SA 3SRSX 3JWFA 3KJRA 4KFJA 1DG5A 3DL5A 8DFRA 4M6KA 1U72A 1DRHA 4DDRA 4G8ZX 5HQYA 4PSTA 1PDBA 1RA1A 3S3VA 1DG8A 3NXOA 3FRFX 3Q1HA 3QLWA 4XT5A 1MVTA 1S3UA 4KYAA 1RX6A 1LY3A 1RH3A 1IA3A 2ANQA 3F0VX 4ELBA 3UM8A 3JWKA 2CIGA 2XW7A 1E26A 4H96A 4KBNA 3QGTA 1DREA 4KNEA 4M7UA 1DRAA 1KMSA 1DRBA 2W3BA 1JOLA 4OR7A 1AI9A 3IRNA 4RGCA 1RX4A 4P3QA 5EAJA 2W9HA 4KJLA 4HOFA 4NX6A 1DR1A 4ELFA 3DRCA 4KJKA 3FY8X 2W9GA 3L3RA 4KM2A 2HM9A 3FQOA 2W3VA 1RA3A 1DYRA 4EILA 1DYJA 4G3MA 3JWMA 4PTHA 2CD2A 3SRRX 3QLZA 1DDRA 1J3KA 1DR6A 1OHJA 4KM0A 1OHKA 3SRWX 4PDJA 4LAEX 3K2HA 1DF7A 1AOEA 3IRMA 4FGGA 2O7PA 1DYHA 1RX5A 4QLFA 3S9UA 3FRAX 1KMVA 3M09A 5ECXA 1HFRA 3JW5A 4QJZD 3SGYA 6DFRA 3KJSA 2QK8A 4XT8A 4TU5X 3FREX 3FRDX 1RA9A 3SA2A 1RA2A 3DAUA 3GI2A 1U70A 4XT6A 1S3YA 3FQCA 4DP3A 3F8ZA 3F0QX 1RF7A 3FRBX 4XRBA 1BOZA 4M6LA 3R33A 1IA4A 4IXGX 4Q67A 3DATA 5HI6A 1DDSA 4KD7A 3DGAA 3IROA 3F91A 4LAGX 5JG0X 1RC4A 4X5JA 4KAKA 1BZFA 4QJCA 3NZBX 5HF2X 3K47A 5HSUA 1JUVA 2DRCA 1DISA 3GHCA 2GD9A 1HFQA 1LUDA 4EIGA 1RX7A 4IXED 1DR2A 4M7VA 3NXRA 3QG2A 1HFPA 3IX9A 2P4GA 1DLRA 3NXYA 3FL8A 4XT4A 4H98A 4H97A 3NRRA 1U71A 3F0SX 3NZ6X 1RX8A 3NZDA
chains in the Genus database with same CATH superfamily
4Q0EA 1ZDRA 5CCCA 2C2SA 3GYFA 4HA7A 1VJ3A 2OBCA 5FDAA 5HUIA 1RG7A 4Q6AA 3QLYA 3HJ3A 2BLCA 2W3WA 2OIPA 3E0BA 3UM6A 4DPDA 2H2QA 1KLKA 3JVXA 2ITHA 1SEJA 2FZHA 4KLXA 1TDRA 4PSSA 4P66A 1AO8A 4DFRA 1RX1A 3SQYX 1QZFA 5HVBA 4G95A 4GH8A 3S7AA 1LY4A 3IA4A 5HVEA 1RX9A 3FYWX 3FL9A 5HT5A 3NXXA 1DR4A 2INQA 1IA1A 4HOEA 3EEKA 3QLSA 3QLXA 3OCHA 3IA5A 1S3WA 1DHJA 1DHFA 1VDRA 4Q0DA 3HBBA 5E8QA 4M6JA 1DG7A 3SAIA 2AZNA 3EEJA 1DLSA 4KJJA 3KGYA 5HQZA 3ZPCA 4PSYA 5JA3A 4PTJA 4HOGA 5HSRA 3K45A 3JSUA 5ECCA 2JYBA 3F8YA 2BLBA 3QYOA 1PD9A 3QFXA 1RB2A 4HA9A 4LAHX 3JTWA 7DFRA 1MVSA 3DFRA 3D84X 2KGKA 2C2TA 2BLAA 3FQFA 3EEMA 3F0XX 4XECX 3FS6A 5HPBA 4FHBA 4P68A 3SRQX 4ELGA 4DPHA 4I1NA 3VCOA 3M08A 1M79A 3FQZA 4KY8A 1DYIA 1RX3A 2D5NA 3EELA 3NXTA 2ZZAA 4KY4A 4I13A 4ECKA 1RA8A 3TD8A 3UM5A 3NXVA 4ELEA 4XE6X 1DHIA 3I8AX 3EIGA 3D80A 3SRUX 3GHWA 3FY9X 4NX7A 3FQVA 4X5IA 2LF1A 5U26A 2HXVA 2W3AA 2FZJA 3NU0A 3ROAA 1CZ3A 3KFYA 2BL9A 4OSGA 1DIUA 3EX8A 1J3IA 3K74A 1RE7A 3JWCA 5HT4A 3TQAA 4X5FA 4EJ1A 4KL9A 3SH2A 3NZ9X 3INVA 4QLGA 1PD8A 2HQPA 4QHVA 3DG8A 3KY8A 2G6VA 3TQBA 3FQ0A 4ELHA 4M2XA 4XT7A 4P3RA 1J3JA 3F0BX 1DR7A 3GHVA 5DXVA 2W9TA 3ZPGA 1M78A 3CSEA 1DRFA 3RG9A 2ANOA 2FZIA 3QL3A 3QLRA 1RB3A 1DR5A 3QYLA 4LEKX 1JOMA 5CC9A 3I3RA 3QL0A 3NTZA 1CD2A 3CD2A 1IA2A 2L28A 3OAFA 4KEBA 2DHFA 1S3VA 2W3MA 4EIZA 1RX2A 4FGHA 4H95A 1D1GA 3FYVX 3F0UX 4X5HA 4QLEA 1RD7A 3N0HA 1YHOA 3NZCX 4CD2A 5HF0X 3NZAX 3RO9A 3TQ9A 2B3ZA 4X5GA 5DFRA 1M7AA 3DL6A 4QI9A 3SR5X 3JW3A 3TQ8A 1DR3A 3LG4A 1DAJA 3SA1A 3CL9A 2D0KA 3CLBA 4IXFX 5U27A 2W9SA 3SRSX 3JWFA 3KJRA 4KFJA 1DG5A 3DL5A 8DFRA 4M6KA 1U72A 1DRHA 4DDRA 4G8ZX 5HQYA 4PSTA 1PDBA 1RA1A 3S3VA 1DG8A 3NXOA 3FRFX 3Q1HA 3QLWA 4XT5A 1MVTA 1S3UA 4KYAA 1RX6A 1LY3A 1RH3A 1IA3A 2ANQA 3F0VX 4ELBA 3UM8A 3JWKA 2CIGA 2XW7A 1E26A 4H96A 4KBNA 3QGTA 1DREA 4KNEA 4M7UA 1DRAA 1KMSA 1DRBA 2W3BA 1JOLA 4OR7A 1AI9A 3IRNA 4RGCA 1RX4A 4P3QA 5EAJA 2W9HA 4KJLA 4HOFA 4NX6A 1DR1A 4ELFA 3DRCA 4KJKA 3FY8X 2W9GA 3L3RA 4KM2A 2HM9A 3FQOA 2W3VA 1RA3A 1DYRA 4EILA 1DYJA 4G3MA 3JWMA 4PTHA 2CD2A 3SRRX 3QLZA 1DDRA 1J3KA 1DR6A 1OHJA 4KM0A 1OHKA 3SRWX 4PDJA 4LAEX 3K2HA 1DF7A 1AOEA 3IRMA 4FGGA 2O7PA 1DYHA 1RX5A 4QLFA 3S9UA 3FRAX 1KMVA 3M09A 5ECXA 1HFRA 3JW5A 4QJZD 3SGYA 6DFRA 3KJSA 2QK8A 4XT8A 4TU5X 3FREX 3FRDX 1RA9A 3SA2A 1RA2A 3DAUA 3GI2A 1U70A 4XT6A 1S3YA 3FQCA 4DP3A 3F8ZA 3F0QX 1RF7A 3FRBX 4XRBA 1BOZA 4M6LA 3R33A 1IA4A 4IXGX 4Q67A 3DATA 5HI6A 1DDSA 4KD7A 3DGAA 3IROA 3F91A 4LAGX 5JG0X 1RC4A 4X5JA 4KAKA 1BZFA 4QJCA 3NZBX 5HF2X 3K47A 5HSUA 1JUVA 2DRCA 1DISA 3GHCA 2GD9A 1HFQA 1LUDA 4EIGA 1RX7A 4IXED 1DR2A 4M7VA 3NXRA 3QG2A 1HFPA 3IX9A 2P4GA 1DLRA 3NXYA 3FL8A 4XT4A 4H98A 4H97A 3NRRA 1U71A 3F0SX 3NZ6X 1RX8A 3NZDA
chains in the Genus database with same CATH topology
4Q0EA 1ZDRA 5CCCA 2C2SA 3GYFA 4HA7A 1VJ3A 2OBCA 5FDAA 5HUIA 1RG7A 4Q6AA 3QLYA 3HJ3A 2BLCA 2W3WA 2OIPA 3E0BA 3UM6A 4DPDA 2H2QA 1KLKA 3JVXA 2ITHA 1SEJA 2FZHA 4KLXA 1TDRA 4PSSA 4P66A 1AO8A 4DFRA 1RX1A 3SQYX 1QZFA 5HVBA 4G95A 4GH8A 3S7AA 1LY4A 3IA4A 5HVEA 1RX9A 3FYWX 3FL9A 5HT5A 3NXXA 1DR4A 2INQA 1IA1A 4HOEA 3EEKA 3QLSA 3QLXA 3OCHA 3IA5A 1S3WA 1DHJA 1DHFA 1VDRA 4Q0DA 3HBBA 5E8QA 4M6JA 1DG7A 3SAIA 2AZNA 3EEJA 1DLSA 4KJJA 3KGYA 5HQZA 3ZPCA 4PSYA 5JA3A 4PTJA 4HOGA 5HSRA 3K45A 3JSUA 5ECCA 2JYBA 3F8YA 2BLBA 3QYOA 1PD9A 3QFXA 1RB2A 4HA9A 4LAHX 3JTWA 7DFRA 1MVSA 3DFRA 3D84X 2KGKA 2C2TA 2BLAA 3FQFA 3EEMA 3F0XX 4XECX 3FS6A 5HPBA 4FHBA 4P68A 3SRQX 4ELGA 4DPHA 4I1NA 3VCOA 3M08A 1M79A 3FQZA 4KY8A 1DYIA 1RX3A 2D5NA 3EELA 3NXTA 2ZZAA 4KY4A 4I13A 4ECKA 1RA8A 3TD8A 3UM5A 3NXVA 4ELEA 4XE6X 1DHIA 3I8AX 3EIGA 3D80A 3SRUX 3GHWA 3FY9X 4NX7A 3FQVA 4X5IA 2LF1A 5U26A 2HXVA 2W3AA 2FZJA 3NU0A 3ROAA 1CZ3A 3KFYA 2BL9A 4OSGA 1DIUA 3EX8A 1J3IA 3K74A 1RE7A 3JWCA 5HT4A 3TQAA 4X5FA 4EJ1A 4KL9A 3SH2A 3NZ9X 3INVA 4QLGA 1PD8A 2HQPA 4QHVA 3DG8A 3KY8A 2G6VA 3TQBA 3FQ0A 4ELHA 4M2XA 4XT7A 4P3RA 1J3JA 3F0BX 1DR7A 3GHVA 5DXVA 2W9TA 3ZPGA 1M78A 3CSEA 1DRFA 3RG9A 2ANOA 2FZIA 3QL3A 3QLRA 1RB3A 1DR5A 3QYLA 4LEKX 1JOMA 5CC9A 3I3RA 3QL0A 3NTZA 1CD2A 3CD2A 1IA2A 2L28A 3OAFA 4KEBA 2DHFA 1S3VA 2W3MA 4EIZA 1RX2A 4FGHA 4H95A 1D1GA 3FYVX 3F0UX 4X5HA 4QLEA 1RD7A 3N0HA 1YHOA 3NZCX 4CD2A 5HF0X 3NZAX 3RO9A 3TQ9A 2B3ZA 4X5GA 5DFRA 1M7AA 3DL6A 4QI9A 3SR5X 3JW3A 3TQ8A 1DR3A 3LG4A 1DAJA 3SA1A 3CL9A 2D0KA 3CLBA 4IXFX 5U27A 2W9SA 3SRSX 3JWFA 3KJRA 4KFJA 1DG5A 3DL5A 8DFRA 4M6KA 1U72A 1DRHA 4DDRA 4G8ZX 5HQYA 4PSTA 1PDBA 1RA1A 3S3VA 1DG8A 3NXOA 3FRFX 3Q1HA 3QLWA 4XT5A 1MVTA 1S3UA 4KYAA 1RX6A 1LY3A 1RH3A 1IA3A 2ANQA 3F0VX 4ELBA 3UM8A 3JWKA 2CIGA 2XW7A 1E26A 4H96A 4KBNA 3QGTA 1DREA 4KNEA 4M7UA 1DRAA 1KMSA 1DRBA 2W3BA 1JOLA 4OR7A 1AI9A 3IRNA 4RGCA 1RX4A 4P3QA 5EAJA 2W9HA 4KJLA 4HOFA 4NX6A 1DR1A 4ELFA 3DRCA 4KJKA 3FY8X 2W9GA 3L3RA 4KM2A 2HM9A 3FQOA 2W3VA 1RA3A 1DYRA 4EILA 1DYJA 4G3MA 3JWMA 4PTHA 2CD2A 3SRRX 3QLZA 1DDRA 1J3KA 1DR6A 1OHJA 4KM0A 1OHKA 3SRWX 4PDJA 4LAEX 3K2HA 1DF7A 1AOEA 3IRMA 4FGGA 2O7PA 1DYHA 1RX5A 4QLFA 3S9UA 3FRAX 1KMVA 3M09A 5ECXA 1HFRA 3JW5A 4QJZD 3SGYA 6DFRA 3KJSA 2QK8A 4XT8A 4TU5X 3FREX 3FRDX 1RA9A 3SA2A 1RA2A 3DAUA 3GI2A 1U70A 4XT6A 1S3YA 3FQCA 4DP3A 3F8ZA 3F0QX 1RF7A 3FRBX 4XRBA 1BOZA 4M6LA 3R33A 1IA4A 4IXGX 4Q67A 3DATA 5HI6A 1DDSA 4KD7A 3DGAA 3IROA 3F91A 4LAGX 5JG0X 1RC4A 4X5JA 4KAKA 1BZFA 4QJCA 3NZBX 5HF2X 3K47A 5HSUA 1JUVA 2DRCA 1DISA 3GHCA 2GD9A 1HFQA 1LUDA 4EIGA 1RX7A 4IXED 1DR2A 4M7VA 3NXRA 3QG2A 1HFPA 3IX9A 2P4GA 1DLRA 3NXYA 3FL8A 4XT4A 4H98A 4H97A 3NRRA 1U71A 3F0SX 3NZ6X 1RX8A 3NZDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q0E A;  1ZDR A;  5CCC A;  2C2S A;  3GYF A;  4HA7 A;  1VJ3 A;  2OBC A;  5FDA A;  5HUI A;  1RG7 A;  4Q6A A;  3QLY A;  3HJ3 A;  2BLC A;  2W3W A;  2OIP A;  3E0B A;  3UM6 A;  4DPD A;  2H2Q A;  1KLK A;  3JVX A;  2ITH A;  1SEJ A;  2FZH A;  4KLX A;  1TDR A;  4PSS A;  4P66 A;  1AO8 A;  4DFR A;  1RX1 A;  3SQY X;  1QZF A;  5HVB A;  4G95 A;  4GH8 A;  3S7A A;  1LY4 A;  3IA4 A;  5HVE A;  1RX9 A;  3FYW X;  3FL9 A;  5HT5 A;  3NXX A;  1DR4 A;  2INQ A;  1IA1 A;  4HOE A;  3EEK A;  3QLS A;  3QLX A;  3OCH A;  3IA5 A;  1S3W A;  1DHJ A;  1DHF A;  1VDR A;  4Q0D A;  3HBB A;  5E8Q A;  4M6J A;  1DG7 A;  3SAI A;  2AZN A;  3EEJ A;  1DLS A;  4KJJ A;  3KGY A;  5HQZ A;  3ZPC A;  4PSY A;  5JA3 A;  4PTJ A;  4HOG A;  5HSR A;  3K45 A;  3JSU A;  5ECC A;  2JYB A;  3F8Y A;  2BLB A;  3QYO A;  1PD9 A;  3QFX A;  1RB2 A;  4HA9 A;  4LAH X;  3JTW A;  7DFR A;  1MVS A;  3DFR A;  3D84 X;  2KGK A;  2C2T A;  2BLA A;  3FQF A;  3EEM A;  3F0X X;  4XEC X;  3FS6 A;  5HPB A;  4FHB A;  4P68 A;  3SRQ X;  4ELG A;  4DPH A;  4I1N A;  3VCO A;  3M08 A;  1M79 A;  3FQZ A;  4KY8 A;  1DYI A;  1RX3 A;  2D5N A;  3EEL A;  3NXT A;  2ZZA A;  4KY4 A;  4I13 A;  4ECK A;  1RA8 A;  3TD8 A;  3UM5 A;  3NXV A;  4ELE A;  4XE6 X;  1DHI A;  3I8A X;  3EIG A;  3D80 A;  3SRU X;  3GHW A;  3FY9 X;  4NX7 A;  3FQV A;  4X5I A;  2LF1 A;  5U26 A;  2HXV A;  2W3A A;  2FZJ A;  3NU0 A;  3ROA A;  1CZ3 A;  3KFY A;  2BL9 A;  4OSG A;  1DIU A;  3EX8 A;  1J3I A;  3K74 A;  1RE7 A;  3JWC A;  5HT4 A;  3TQA A;  4X5F A;  4EJ1 A;  4KL9 A;  3SH2 A;  3NZ9 X;  3INV A;  4QLG A;  1PD8 A;  2HQP A;  4QHV A;  3DG8 A;  3KY8 A;  2G6V A;  3TQB A;  3FQ0 A;  4ELH A;  4M2X A;  4XT7 A;  4P3R A;  1J3J A;  3F0B X;  1DR7 A;  3GHV A;  5DXV A;  2W9T A;  3ZPG A;  1M78 A;  3CSE A;  1DRF A;  3RG9 A;  2ANO A;  2FZI A;  3QL3 A;  3QLR A;  1RB3 A;  1DR5 A;  3QYL A;  4LEK X;  1JOM A;  5CC9 A;  3I3R A;  3QL0 A;  3NTZ A;  1CD2 A;  3CD2 A;  1IA2 A;  2L28 A;  3OAF A;  4KEB A;  2DHF A;  1S3V A;  2W3M A;  4EIZ A;  1RX2 A;  4FGH A;  4H95 A;  1D1G A;  3FYV X;  3F0U X;  4X5H A;  4QLE A;  1RD7 A;  3N0H A;  1YHO A;  3NZC X;  4CD2 A;  5HF0 X;  3NZA X;  3RO9 A;  3TQ9 A;  2B3Z A;  4X5G A;  5DFR A;  1M7A A;  3DL6 A;  4QI9 A;  3SR5 X;  3JW3 A;  3TQ8 A;  1DR3 A;  3LG4 A;  1DAJ A;  3SA1 A;  3CL9 A;  2D0K A;  3CLB A;  4IXF X;  5U27 A;  2W9S A;  3SRS X;  3JWF A;  3KJR A;  4KFJ A;  1DG5 A;  3DL5 A;  8DFR A;  4M6K A;  1U72 A;  1DRH A;  4DDR A;  4G8Z X;  5HQY A;  4PST A;  1PDB A;  1RA1 A;  3S3V A;  1DG8 A;  3NXO A;  3FRF X;  3Q1H A;  3QLW A;  4XT5 A;  1MVT A;  1S3U A;  4KYA A;  1RX6 A;  1LY3 A;  1RH3 A;  1IA3 A;  2ANQ A;  3F0V X;  4ELB A;  3UM8 A;  3JWK A;  2CIG A;  2XW7 A;  1E26 A;  4H96 A;  4KBN A;  3QGT A;  1DRE A;  4KNE A;  4M7U A;  1DRA A;  1KMS A;  1DRB A;  2W3B A;  1JOL A;  4OR7 A;  1AI9 A;  3IRN A;  4RGC A;  1RX4 A;  4P3Q A;  5EAJ A;  2W9H A;  4KJL A;  4HOF A;  4NX6 A;  1DR1 A;  4ELF A;  3DRC A;  4KJK A;  3FY8 X;  2W9G A;  3L3R A;  4KM2 A;  2HM9 A;  3FQO A;  2W3V A;  1RA3 A;  1DYR A;  4EIL A;  1DYJ A;  4G3M A;  3JWM A;  4PTH A;  2CD2 A;  3SRR X;  3QLZ A;  1DDR A;  1J3K A;  1DR6 A;  1OHJ A;  4KM0 A;  1OHK A;  3SRW X;  4PDJ A;  4LAE X;  3K2H A;  1DF7 A;  1AOE A;  3IRM A;  4FGG A;  2O7P A;  1DYH A;  1RX5 A;  4QLF A;  3S9U A;  3FRA X;  1KMV A;  3M09 A;  5ECX A;  1HFR A;  3JW5 A;  4QJZ D;  3SGY A;  6DFR A;  3KJS A;  2QK8 A;  4XT8 A;  4TU5 X;  3FRE X;  3FRD X;  1RA9 A;  3SA2 A;  1RA2 A;  3DAU A;  3GI2 A;  1U70 A;  4XT6 A;  1S3Y A;  3FQC A;  4DP3 A;  3F8Z A;  3F0Q X;  1RF7 A;  3FRB X;  4XRB A;  1BOZ A;  4M6L A;  3R33 A;  1IA4 A;  4IXG X;  4Q67 A;  3DAT A;  5HI6 A;  1DDS A;  4KD7 A;  3DGA A;  3IRO A;  3F91 A;  4LAG X;  5JG0 X;  1RC4 A;  4X5J A;  4KAK A;  1BZF A;  4QJC A;  3NZB X;  5HF2 X;  3K47 A;  5HSU A;  1JUV A;  2DRC A;  1DIS A;  3GHC A;  2GD9 A;  1HFQ A;  1LUD A;  4EIG A;  1RX7 A;  4IXE D;  1DR2 A;  4M7V A;  3NXR A;  3QG2 A;  1HFP A;  3IX9 A;  2P4G A;  1DLR A;  3NXY A;  3FL8 A;  4XT4 A;  4H98 A;  4H97 A;  3NRR A;  1U71 A;  3F0S X;  3NZ6 X;  1RX8 A;  3NZD A; 
#chains in the Genus database with same CATH topology
 4Q0E A;  1ZDR A;  5CCC A;  2C2S A;  3GYF A;  4HA7 A;  1VJ3 A;  2OBC A;  5FDA A;  5HUI A;  1RG7 A;  4Q6A A;  3QLY A;  3HJ3 A;  2BLC A;  2W3W A;  2OIP A;  3E0B A;  3UM6 A;  4DPD A;  2H2Q A;  1KLK A;  3JVX A;  2ITH A;  1SEJ A;  2FZH A;  4KLX A;  1TDR A;  4PSS A;  4P66 A;  1AO8 A;  4DFR A;  1RX1 A;  3SQY X;  1QZF A;  5HVB A;  4G95 A;  4GH8 A;  3S7A A;  1LY4 A;  3IA4 A;  5HVE A;  1RX9 A;  3FYW X;  3FL9 A;  5HT5 A;  3NXX A;  1DR4 A;  2INQ A;  1IA1 A;  4HOE A;  3EEK A;  3QLS A;  3QLX A;  3OCH A;  3IA5 A;  1S3W A;  1DHJ A;  1DHF A;  1VDR A;  4Q0D A;  3HBB A;  5E8Q A;  4M6J A;  1DG7 A;  3SAI A;  2AZN A;  3EEJ A;  1DLS A;  4KJJ A;  3KGY A;  5HQZ A;  3ZPC A;  4PSY A;  5JA3 A;  4PTJ A;  4HOG A;  5HSR A;  3K45 A;  3JSU A;  5ECC A;  2JYB A;  3F8Y A;  2BLB A;  3QYO A;  1PD9 A;  3QFX A;  1RB2 A;  4HA9 A;  4LAH X;  3JTW A;  7DFR A;  1MVS A;  3DFR A;  3D84 X;  2KGK A;  2C2T A;  2BLA A;  3FQF A;  3EEM A;  3F0X X;  4XEC X;  3FS6 A;  5HPB A;  4FHB A;  4P68 A;  3SRQ X;  4ELG A;  4DPH A;  4I1N A;  3VCO A;  3M08 A;  1M79 A;  3FQZ A;  4KY8 A;  1DYI A;  1RX3 A;  2D5N A;  3EEL A;  3NXT A;  2ZZA A;  4KY4 A;  4I13 A;  4ECK A;  1RA8 A;  3TD8 A;  3UM5 A;  3NXV A;  4ELE A;  4XE6 X;  1DHI A;  3I8A X;  3EIG A;  3D80 A;  3SRU X;  3GHW A;  3FY9 X;  4NX7 A;  3FQV A;  4X5I A;  2LF1 A;  5U26 A;  2HXV A;  2W3A A;  2FZJ A;  3NU0 A;  3ROA A;  1CZ3 A;  3KFY A;  2BL9 A;  4OSG A;  1DIU A;  3EX8 A;  1J3I A;  3K74 A;  1RE7 A;  3JWC A;  5HT4 A;  3TQA A;  4X5F A;  4EJ1 A;  4KL9 A;  3SH2 A;  3NZ9 X;  3INV A;  4QLG A;  1PD8 A;  2HQP A;  4QHV A;  3DG8 A;  3KY8 A;  2G6V A;  3TQB A;  3FQ0 A;  4ELH A;  4M2X A;  4XT7 A;  4P3R A;  1J3J A;  3F0B X;  1DR7 A;  3GHV A;  5DXV A;  2W9T A;  3ZPG A;  1M78 A;  3CSE A;  1DRF A;  3RG9 A;  2ANO A;  2FZI A;  3QL3 A;  3QLR A;  1RB3 A;  1DR5 A;  3QYL A;  4LEK X;  1JOM A;  5CC9 A;  3I3R A;  3QL0 A;  3NTZ A;  1CD2 A;  3CD2 A;  1IA2 A;  2L28 A;  3OAF A;  4KEB A;  2DHF A;  1S3V A;  2W3M A;  4EIZ A;  1RX2 A;  4FGH A;  4H95 A;  1D1G A;  3FYV X;  3F0U X;  4X5H A;  4QLE A;  1RD7 A;  3N0H A;  1YHO A;  3NZC X;  4CD2 A;  5HF0 X;  3NZA X;  3RO9 A;  3TQ9 A;  2B3Z A;  4X5G A;  5DFR A;  1M7A A;  3DL6 A;  4QI9 A;  3SR5 X;  3JW3 A;  3TQ8 A;  1DR3 A;  3LG4 A;  1DAJ A;  3SA1 A;  3CL9 A;  2D0K A;  3CLB A;  4IXF X;  5U27 A;  2W9S A;  3SRS X;  3JWF A;  3KJR A;  4KFJ A;  1DG5 A;  3DL5 A;  8DFR A;  4M6K A;  1U72 A;  1DRH A;  4DDR A;  4G8Z X;  5HQY A;  4PST A;  1PDB A;  1RA1 A;  3S3V A;  1DG8 A;  3NXO A;  3FRF X;  3Q1H A;  3QLW A;  4XT5 A;  1MVT A;  1S3U A;  4KYA A;  1RX6 A;  1LY3 A;  1RH3 A;  1IA3 A;  2ANQ A;  3F0V X;  4ELB A;  3UM8 A;  3JWK A;  2CIG A;  2XW7 A;  1E26 A;  4H96 A;  4KBN A;  3QGT A;  1DRE A;  4KNE A;  4M7U A;  1DRA A;  1KMS A;  1DRB A;  2W3B A;  1JOL A;  4OR7 A;  1AI9 A;  3IRN A;  4RGC A;  1RX4 A;  4P3Q A;  5EAJ A;  2W9H A;  4KJL A;  4HOF A;  4NX6 A;  1DR1 A;  4ELF A;  3DRC A;  4KJK A;  3FY8 X;  2W9G A;  3L3R A;  4KM2 A;  2HM9 A;  3FQO A;  2W3V A;  1RA3 A;  1DYR A;  4EIL A;  1DYJ A;  4G3M A;  3JWM A;  4PTH A;  2CD2 A;  3SRR X;  3QLZ A;  1DDR A;  1J3K A;  1DR6 A;  1OHJ A;  4KM0 A;  1OHK A;  3SRW X;  4PDJ A;  4LAE X;  3K2H A;  1DF7 A;  1AOE A;  3IRM A;  4FGG A;  2O7P A;  1DYH A;  1RX5 A;  4QLF A;  3S9U A;  3FRA X;  1KMV A;  3M09 A;  5ECX A;  1HFR A;  3JW5 A;  4QJZ D;  3SGY A;  6DFR A;  3KJS A;  2QK8 A;  4XT8 A;  4TU5 X;  3FRE X;  3FRD X;  1RA9 A;  3SA2 A;  1RA2 A;  3DAU A;  3GI2 A;  1U70 A;  4XT6 A;  1S3Y A;  3FQC A;  4DP3 A;  3F8Z A;  3F0Q X;  1RF7 A;  3FRB X;  4XRB A;  1BOZ A;  4M6L A;  3R33 A;  1IA4 A;  4IXG X;  4Q67 A;  3DAT A;  5HI6 A;  1DDS A;  4KD7 A;  3DGA A;  3IRO A;  3F91 A;  4LAG X;  5JG0 X;  1RC4 A;  4X5J A;  4KAK A;  1BZF A;  4QJC A;  3NZB X;  5HF2 X;  3K47 A;  5HSU A;  1JUV A;  2DRC A;  1DIS A;  3GHC A;  2GD9 A;  1HFQ A;  1LUD A;  4EIG A;  1RX7 A;  4IXE D;  1DR2 A;  4M7V A;  3NXR A;  3QG2 A;  1HFP A;  3IX9 A;  2P4G A;  1DLR A;  3NXY A;  3FL8 A;  4XT4 A;  4H98 A;  4H97 A;  3NRR A;  1U71 A;  3F0S X;  3NZ6 X;  1RX8 A;  3NZD A; 
#chains in the Genus database with same CATH homology
 4Q0E A;  1ZDR A;  5CCC A;  2C2S A;  3GYF A;  4HA7 A;  1VJ3 A;  2OBC A;  5FDA A;  5HUI A;  1RG7 A;  4Q6A A;  3QLY A;  3HJ3 A;  2BLC A;  2W3W A;  2OIP A;  3E0B A;  3UM6 A;  4DPD A;  2H2Q A;  1KLK A;  3JVX A;  2ITH A;  1SEJ A;  2FZH A;  4KLX A;  1TDR A;  4PSS A;  4P66 A;  1AO8 A;  4DFR A;  1RX1 A;  3SQY X;  1QZF A;  5HVB A;  4G95 A;  4GH8 A;  3S7A A;  1LY4 A;  3IA4 A;  5HVE A;  1RX9 A;  3FYW X;  3FL9 A;  5HT5 A;  3NXX A;  1DR4 A;  2INQ A;  1IA1 A;  4HOE A;  3EEK A;  3QLS A;  3QLX A;  3OCH A;  3IA5 A;  1S3W A;  1DHJ A;  1DHF A;  1VDR A;  4Q0D A;  3HBB A;  5E8Q A;  4M6J A;  1DG7 A;  3SAI A;  2AZN A;  3EEJ A;  1DLS A;  4KJJ A;  3KGY A;  5HQZ A;  3ZPC A;  4PSY A;  5JA3 A;  4PTJ A;  4HOG A;  5HSR A;  3K45 A;  3JSU A;  5ECC A;  2JYB A;  3F8Y A;  2BLB A;  3QYO A;  1PD9 A;  3QFX A;  1RB2 A;  4HA9 A;  4LAH X;  3JTW A;  7DFR A;  1MVS A;  3DFR A;  3D84 X;  2KGK A;  2C2T A;  2BLA A;  3FQF A;  3EEM A;  3F0X X;  4XEC X;  3FS6 A;  5HPB A;  4FHB A;  4P68 A;  3SRQ X;  4ELG A;  4DPH A;  4I1N A;  3VCO A;  3M08 A;  1M79 A;  3FQZ A;  4KY8 A;  1DYI A;  1RX3 A;  2D5N A;  3EEL A;  3NXT A;  2ZZA A;  4KY4 A;  4I13 A;  4ECK A;  1RA8 A;  3TD8 A;  3UM5 A;  3NXV A;  4ELE A;  4XE6 X;  1DHI A;  3I8A X;  3EIG A;  3D80 A;  3SRU X;  3GHW A;  3FY9 X;  4NX7 A;  3FQV A;  4X5I A;  2LF1 A;  5U26 A;  2HXV A;  2W3A A;  2FZJ A;  3NU0 A;  3ROA A;  1CZ3 A;  3KFY A;  2BL9 A;  4OSG A;  1DIU A;  3EX8 A;  1J3I A;  3K74 A;  1RE7 A;  3JWC A;  5HT4 A;  3TQA A;  4X5F A;  4EJ1 A;  4KL9 A;  3SH2 A;  3NZ9 X;  3INV A;  4QLG A;  1PD8 A;  2HQP A;  4QHV A;  3DG8 A;  3KY8 A;  2G6V A;  3TQB A;  3FQ0 A;  4ELH A;  4M2X A;  4XT7 A;  4P3R A;  1J3J A;  3F0B X;  1DR7 A;  3GHV A;  5DXV A;  2W9T A;  3ZPG A;  1M78 A;  3CSE A;  1DRF A;  3RG9 A;  2ANO A;  2FZI A;  3QL3 A;  3QLR A;  1RB3 A;  1DR5 A;  3QYL A;  4LEK X;  1JOM A;  5CC9 A;  3I3R A;  3QL0 A;  3NTZ A;  1CD2 A;  3CD2 A;  1IA2 A;  2L28 A;  3OAF A;  4KEB A;  2DHF A;  1S3V A;  2W3M A;  4EIZ A;  1RX2 A;  4FGH A;  4H95 A;  1D1G A;  3FYV X;  3F0U X;  4X5H A;  4QLE A;  1RD7 A;  3N0H A;  1YHO A;  3NZC X;  4CD2 A;  5HF0 X;  3NZA X;  3RO9 A;  3TQ9 A;  2B3Z A;  4X5G A;  5DFR A;  1M7A A;  3DL6 A;  4QI9 A;  3SR5 X;  3JW3 A;  3TQ8 A;  1DR3 A;  3LG4 A;  1DAJ A;  3SA1 A;  3CL9 A;  2D0K A;  3CLB A;  4IXF X;  5U27 A;  2W9S A;  3SRS X;  3JWF A;  3KJR A;  4KFJ A;  1DG5 A;  3DL5 A;  8DFR A;  4M6K A;  1U72 A;  1DRH A;  4DDR A;  4G8Z X;  5HQY A;  4PST A;  1PDB A;  1RA1 A;  3S3V A;  1DG8 A;  3NXO A;  3FRF X;  3Q1H A;  3QLW A;  4XT5 A;  1MVT A;  1S3U A;  4KYA A;  1RX6 A;  1LY3 A;  1RH3 A;  1IA3 A;  2ANQ A;  3F0V X;  4ELB A;  3UM8 A;  3JWK A;  2CIG A;  2XW7 A;  1E26 A;  4H96 A;  4KBN A;  3QGT A;  1DRE A;  4KNE A;  4M7U A;  1DRA A;  1KMS A;  1DRB A;  2W3B A;  1JOL A;  4OR7 A;  1AI9 A;  3IRN A;  4RGC A;  1RX4 A;  4P3Q A;  5EAJ A;  2W9H A;  4KJL A;  4HOF A;  4NX6 A;  1DR1 A;  4ELF A;  3DRC A;  4KJK A;  3FY8 X;  2W9G A;  3L3R A;  4KM2 A;  2HM9 A;  3FQO A;  2W3V A;  1RA3 A;  1DYR A;  4EIL A;  1DYJ A;  4G3M A;  3JWM A;  4PTH A;  2CD2 A;  3SRR X;  3QLZ A;  1DDR A;  1J3K A;  1DR6 A;  1OHJ A;  4KM0 A;  1OHK A;  3SRW X;  4PDJ A;  4LAE X;  3K2H A;  1DF7 A;  1AOE A;  3IRM A;  4FGG A;  2O7P A;  1DYH A;  1RX5 A;  4QLF A;  3S9U A;  3FRA X;  1KMV A;  3M09 A;  5ECX A;  1HFR A;  3JW5 A;  4QJZ D;  3SGY A;  6DFR A;  3KJS A;  2QK8 A;  4XT8 A;  4TU5 X;  3FRE X;  3FRD X;  1RA9 A;  3SA2 A;  1RA2 A;  3DAU A;  3GI2 A;  1U70 A;  4XT6 A;  1S3Y A;  3FQC A;  4DP3 A;  3F8Z A;  3F0Q X;  1RF7 A;  3FRB X;  4XRB A;  1BOZ A;  4M6L A;  3R33 A;  1IA4 A;  4IXG X;  4Q67 A;  3DAT A;  5HI6 A;  1DDS A;  4KD7 A;  3DGA A;  3IRO A;  3F91 A;  4LAG X;  5JG0 X;  1RC4 A;  4X5J A;  4KAK A;  1BZF A;  4QJC A;  3NZB X;  5HF2 X;  3K47 A;  5HSU A;  1JUV A;  2DRC A;  1DIS A;  3GHC A;  2GD9 A;  1HFQ A;  1LUD A;  4EIG A;  1RX7 A;  4IXE D;  1DR2 A;  4M7V A;  3NXR A;  3QG2 A;  1HFP A;  3IX9 A;  2P4G A;  1DLR A;  3NXY A;  3FL8 A;  4XT4 A;  4H98 A;  4H97 A;  3NRR A;  1U71 A;  3F0S X;  3NZ6 X;  1RX8 A;  3NZD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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