1YHOA

Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 35
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2005-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 1yhoA00
3KGYA 5HPBA 4ELFA 1DAJA 1DR1A 3F0BX 1E26A 4ELGA 2QK8A 3NZ9X 1M79A 1AO8A 4ECKA 1HFQA 4H98A 3TQBA 3DAUA 2DRCA 1RA8A 1DRFA 1DR5A 3TD8A 2KGKA 1DRAA 3NXYA 3NU0A 4QHVA 3HJ3A 2H2QA 3FQVA 3TQ9A 4FGGA 3UM5A 1BOZA 3QYLA 3UM8A 2W3MA 4PDJA 3F0QX 7DFRA 4ELBA 2G6VA 3F0UX 1DRBA 3GHVA 4PSSA 4M6JA 4KAKA 3L3RA 4XRBA 3F0XX 3NZBX 3S9UA 1PD9A 4H97A 4M6LA 5HVEA 4KJLA 4ELEA 3NXRA 1QZFA 2W9GA 2HM9A 2XW7A 3RO9A 5HF2X 4XT4A 1RX7A 3I8AX 1DYIA 1RX1A 1JUVA 3F8ZA 3EEJA 3D80A 5CCCA 4XECX 1DHFA 3KFYA 3S3VA 1HFPA 8DFRA 4PSTA 3SRQX 3KJSA 1RF7A 3QG2A 2JYBA 1RG7A 4X5HA 4G95A 4DDRA 4LAHX 3SR5X 4X5JA 3FQOA 2W9SA 3SAIA 2FZIA 3JTWA 1PDBA 4QJCA 3ZPCA 5HQYA 5JA3A 3N0HA 3GI2A 3FQFA 2D0KA 3QGTA 1KMSA 1CD2A 3K47A 4KBNA 1DR4A 4M7UA 2W9TA 1RA2A 4PSYA 1PD8A 3CL9A 3IX9A 3EIGA 3TQAA 4X5IA 5HVBA 3EEMA 3NZ6X 4KYAA 2W3BA 3FRDX 5HT4A 2ITHA 1DDSA 1IA4A 3IA4A 1J3JA 1DDRA 3KJRA 1KMVA 3DGAA 1YHOA 1DISA 1TDRA 3HBBA 5HUIA 4I13A 1OHKA 3FS6A 2LF1A 2ANOA 1M78A 1J3IA 3Q1HA 2INQA 3M08A 1DYJA 4P68A 3S7AA 3ROAA 4HOEA 3ZPGA 4KL9A 3VCOA 2BL9A 4IXED 3FY8X 3JVXA 4XT5A 1RB3A 5EAJA 4KD7A 2OIPA 1LUDA 3JWMA 3QLWA 3EX8A 1DLRA 3JWKA 3QLXA 1U71A 4P3QA 3F91A 1MVSA 2CD2A 5HSRA 3DG8A 3NZDA 4HA9A 3OAFA 4LAGX 4KJJA 3IRMA 1AI9A 1RE7A 3GYFA 1LY4A 1RA1A 1SEJA 4DFRA 3INVA 3FRBX 2BLAA 3FL8A 3SA2A 2P4GA 4KM0A 3K45A 1IA2A 4EIZA 1AOEA 1RA3A 1S3YA 4M6KA 3QLSA 4XT7A 4CD2A 3TQ8A 1RX6A 1RX4A 5E8QA 4OSGA 1DG5A 4TU5X 2C2TA 1BZFA 4RGCA 3I3RA 4P3RA 2HXVA 3QLYA 1DR6A 3JWFA 5HF0X 5DFRA 3FY9X 1RB2A 1DR7A 3LG4A 4GH8A 3FQ0A 2DHFA 3FL9A 3F8YA 4I1NA 4NX6A 2BLCA 3DATA 2OBCA 3FRAX 2ANQA 2HQPA 4IXGX 3K2HA 4M7VA 3DL5A 5ECCA 1RD7A 1D1GA 2BLBA 3D84X 1DIUA 3GHCA 1HFRA 1DLSA 5DXVA 1DHJA 1DRHA 4EIGA 1RX8A 4DPDA 5HQZA 1RX2A 3FRFX 4OR7A 3SGYA 2FZJA 3IA5A 4DPHA 3JW5A 2L28A 1DG8A 1RX9A 1J3KA 1RC4A 4KM2A 1VDRA 1DREA 3EELA 4XE6X 3NZAX 4KLXA 1LY3A 4PTJA 3FQCA 2W3AA 1DR2A 4PTHA 1DYRA 5CC9A 1IA3A 2D5NA 1RH3A 4Q0EA 3NZCX 1U70A 4HOFA 5HSUA 4DP3A 4G3MA 3QYOA 3KY8A 1JOLA 3FYWX 4KFJA 3NRRA 4X5GA 4QI9A 4G8ZX 4QJZD 3IROA 4P66A 5FDAA 3DL6A 3FREX 3DFRA 5U27A 3NXTA 3RG9A 4EILA 3EEKA 1RA9A 3SA1A 2W9HA 3IRNA 4H95A 4EJ1A 4QLEA 2W3WA 3QL0A 3OCHA 2W3VA 3GHWA 1KLKA 4Q0DA 1ZDRA 3SRSX 4XT6A 5JG0X 6DFRA 1RX3A 1S3VA 2GD9A 3E0BA 1DF7A 4KNEA 3SQYX 3NXOA 3NXXA 4X5FA 4KY8A 4KJKA 4Q67A 2C2SA 3QFXA 3R33A 1M7AA 3JWCA 4QLFA 1S3UA 3M09A 5ECXA 1CZ3A 1IA1A 3NXVA 1OHJA 3FQZA 4LAEX 3F0SX 4FGHA 4LEKX 1U72A 4FHBA 3SRWX 3QLRA 4H96A 1DHIA 3CLBA 3NTZA 3SH2A 4KEBA 3JW3A 3F0VX 1S3WA 3QLZA 5HI6A 1DR3A 2B3ZA 4Q6AA 4M2XA 1DYHA 3JSUA 2ZZAA 4KY4A 2AZNA 5HT5A 2O7PA 3UM6A 4QLGA 4ELHA 1MVTA 4IXFX 2FZHA 1VJ3A 3QL3A 1DG7A 3K74A 5U26A 4XT8A 3FYVX 3CSEA 3CD2A 3SRUX 1JOMA 3DRCA 4NX7A 2CIGA 3SRRX 4HOGA 4HA7A 1RX5A
chains in the Genus database with same CATH superfamily
3KGYA 5HPBA 4ELFA 1DAJA 1DR1A 3F0BX 1E26A 4ELGA 2QK8A 3NZ9X 1M79A 1AO8A 4ECKA 1HFQA 4H98A 3TQBA 3DAUA 2DRCA 1RA8A 1DRFA 1DR5A 3TD8A 2KGKA 1DRAA 3NXYA 3NU0A 4QHVA 3HJ3A 2H2QA 3FQVA 3TQ9A 4FGGA 3UM5A 1BOZA 3QYLA 3UM8A 2W3MA 4PDJA 3F0QX 7DFRA 4ELBA 2G6VA 3F0UX 1DRBA 3GHVA 4PSSA 4M6JA 4KAKA 3L3RA 4XRBA 3F0XX 3NZBX 3S9UA 1PD9A 4H97A 4M6LA 5HVEA 4KJLA 4ELEA 3NXRA 1QZFA 2W9GA 2HM9A 2XW7A 3RO9A 5HF2X 4XT4A 1RX7A 3I8AX 1DYIA 1RX1A 1JUVA 3F8ZA 3EEJA 3D80A 5CCCA 4XECX 1DHFA 3KFYA 3S3VA 1HFPA 8DFRA 4PSTA 3SRQX 3KJSA 1RF7A 3QG2A 2JYBA 1RG7A 4X5HA 4G95A 4DDRA 4LAHX 3SR5X 4X5JA 3FQOA 2W9SA 3SAIA 2FZIA 3JTWA 1PDBA 4QJCA 3ZPCA 5HQYA 5JA3A 3N0HA 3GI2A 3FQFA 2D0KA 3QGTA 1KMSA 1CD2A 3K47A 4KBNA 1DR4A 4M7UA 2W9TA 1RA2A 4PSYA 1PD8A 3CL9A 3IX9A 3EIGA 3TQAA 4X5IA 5HVBA 3EEMA 3NZ6X 4KYAA 2W3BA 3FRDX 5HT4A 2ITHA 1DDSA 1IA4A 3IA4A 1J3JA 1DDRA 3KJRA 1KMVA 3DGAA 1YHOA 1DISA 1TDRA 3HBBA 5HUIA 4I13A 1OHKA 3FS6A 2LF1A 2ANOA 1M78A 1J3IA 3Q1HA 2INQA 3M08A 1DYJA 4P68A 3S7AA 3ROAA 4HOEA 3ZPGA 4KL9A 3VCOA 2BL9A 4IXED 3FY8X 3JVXA 4XT5A 1RB3A 5EAJA 4KD7A 2OIPA 1LUDA 3JWMA 3QLWA 3EX8A 1DLRA 3JWKA 3QLXA 1U71A 4P3QA 3F91A 1MVSA 2CD2A 5HSRA 3DG8A 3NZDA 4HA9A 3OAFA 4LAGX 4KJJA 3IRMA 1AI9A 1RE7A 3GYFA 1LY4A 1RA1A 1SEJA 4DFRA 3INVA 3FRBX 2BLAA 3FL8A 3SA2A 2P4GA 4KM0A 3K45A 1IA2A 4EIZA 1AOEA 1RA3A 1S3YA 4M6KA 3QLSA 4XT7A 4CD2A 3TQ8A 1RX6A 1RX4A 5E8QA 4OSGA 1DG5A 4TU5X 2C2TA 1BZFA 4RGCA 3I3RA 4P3RA 2HXVA 3QLYA 1DR6A 3JWFA 5HF0X 5DFRA 3FY9X 1RB2A 1DR7A 3LG4A 4GH8A 3FQ0A 2DHFA 3FL9A 3F8YA 4I1NA 4NX6A 2BLCA 3DATA 2OBCA 3FRAX 2ANQA 2HQPA 4IXGX 3K2HA 4M7VA 3DL5A 5ECCA 1RD7A 1D1GA 2BLBA 3D84X 1DIUA 3GHCA 1HFRA 1DLSA 5DXVA 1DHJA 1DRHA 4EIGA 1RX8A 4DPDA 5HQZA 1RX2A 3FRFX 4OR7A 3SGYA 2FZJA 3IA5A 4DPHA 3JW5A 2L28A 1DG8A 1RX9A 1J3KA 1RC4A 4KM2A 1VDRA 1DREA 3EELA 4XE6X 3NZAX 4KLXA 1LY3A 4PTJA 3FQCA 2W3AA 1DR2A 4PTHA 1DYRA 5CC9A 1IA3A 2D5NA 1RH3A 4Q0EA 3NZCX 1U70A 4HOFA 5HSUA 4DP3A 4G3MA 3QYOA 3KY8A 1JOLA 3FYWX 4KFJA 3NRRA 4X5GA 4QI9A 4G8ZX 4QJZD 3IROA 4P66A 5FDAA 3DL6A 3FREX 3DFRA 5U27A 3NXTA 3RG9A 4EILA 3EEKA 1RA9A 3SA1A 2W9HA 3IRNA 4H95A 4EJ1A 4QLEA 2W3WA 3QL0A 3OCHA 2W3VA 3GHWA 1KLKA 4Q0DA 1ZDRA 3SRSX 4XT6A 5JG0X 6DFRA 1RX3A 1S3VA 2GD9A 3E0BA 1DF7A 4KNEA 3SQYX 3NXOA 3NXXA 4X5FA 4KY8A 4KJKA 4Q67A 2C2SA 3QFXA 3R33A 1M7AA 3JWCA 4QLFA 1S3UA 3M09A 5ECXA 1CZ3A 1IA1A 3NXVA 1OHJA 3FQZA 4LAEX 3F0SX 4FGHA 4LEKX 1U72A 4FHBA 3SRWX 3QLRA 4H96A 1DHIA 3CLBA 3NTZA 3SH2A 4KEBA 3JW3A 3F0VX 1S3WA 3QLZA 5HI6A 1DR3A 2B3ZA 4Q6AA 4M2XA 1DYHA 3JSUA 2ZZAA 4KY4A 2AZNA 5HT5A 2O7PA 3UM6A 4QLGA 4ELHA 1MVTA 4IXFX 2FZHA 1VJ3A 3QL3A 1DG7A 3K74A 5U26A 4XT8A 3FYVX 3CSEA 3CD2A 3SRUX 1JOMA 3DRCA 4NX7A 2CIGA 3SRRX 4HOGA 4HA7A 1RX5A
chains in the Genus database with same CATH topology
3KGYA 5HPBA 4ELFA 1DAJA 1DR1A 3F0BX 1E26A 4ELGA 2QK8A 3NZ9X 1M79A 1AO8A 4ECKA 1HFQA 4H98A 3TQBA 3DAUA 2DRCA 1RA8A 1DRFA 1DR5A 3TD8A 2KGKA 1DRAA 3NXYA 3NU0A 4QHVA 3HJ3A 2H2QA 3FQVA 3TQ9A 4FGGA 3UM5A 1BOZA 3QYLA 3UM8A 2W3MA 4PDJA 3F0QX 7DFRA 4ELBA 2G6VA 3F0UX 1DRBA 3GHVA 4PSSA 4M6JA 4KAKA 3L3RA 4XRBA 3F0XX 3NZBX 3S9UA 1PD9A 4H97A 4M6LA 5HVEA 4KJLA 4ELEA 3NXRA 1QZFA 2W9GA 2HM9A 2XW7A 3RO9A 5HF2X 4XT4A 1RX7A 3I8AX 1DYIA 1RX1A 1JUVA 3F8ZA 3EEJA 3D80A 5CCCA 4XECX 1DHFA 3KFYA 3S3VA 1HFPA 8DFRA 4PSTA 3SRQX 3KJSA 1RF7A 3QG2A 2JYBA 1RG7A 4X5HA 4G95A 4DDRA 4LAHX 3SR5X 4X5JA 3FQOA 2W9SA 3SAIA 2FZIA 3JTWA 1PDBA 4QJCA 3ZPCA 5HQYA 5JA3A 3N0HA 3GI2A 3FQFA 2D0KA 3QGTA 1KMSA 1CD2A 3K47A 4KBNA 1DR4A 4M7UA 2W9TA 1RA2A 4PSYA 1PD8A 3CL9A 3IX9A 3EIGA 3TQAA 4X5IA 5HVBA 3EEMA 3NZ6X 4KYAA 2W3BA 3FRDX 5HT4A 2ITHA 1DDSA 1IA4A 3IA4A 1J3JA 1DDRA 3KJRA 1KMVA 3DGAA 1YHOA 1DISA 1TDRA 3HBBA 5HUIA 4I13A 1OHKA 3FS6A 2LF1A 2ANOA 1M78A 1J3IA 3Q1HA 2INQA 3M08A 1DYJA 4P68A 3S7AA 3ROAA 4HOEA 3ZPGA 4KL9A 3VCOA 2BL9A 4IXED 3FY8X 3JVXA 4XT5A 1RB3A 5EAJA 4KD7A 2OIPA 1LUDA 3JWMA 3QLWA 3EX8A 1DLRA 3JWKA 3QLXA 1U71A 4P3QA 3F91A 1MVSA 2CD2A 5HSRA 3DG8A 3NZDA 4HA9A 3OAFA 4LAGX 4KJJA 3IRMA 1AI9A 1RE7A 3GYFA 1LY4A 1RA1A 1SEJA 4DFRA 3INVA 3FRBX 2BLAA 3FL8A 3SA2A 2P4GA 4KM0A 3K45A 1IA2A 4EIZA 1AOEA 1RA3A 1S3YA 4M6KA 3QLSA 4XT7A 4CD2A 3TQ8A 1RX6A 1RX4A 5E8QA 4OSGA 1DG5A 4TU5X 2C2TA 1BZFA 4RGCA 3I3RA 4P3RA 2HXVA 3QLYA 1DR6A 3JWFA 5HF0X 5DFRA 3FY9X 1RB2A 1DR7A 3LG4A 4GH8A 3FQ0A 2DHFA 3FL9A 3F8YA 4I1NA 4NX6A 2BLCA 3DATA 2OBCA 3FRAX 2ANQA 2HQPA 4IXGX 3K2HA 4M7VA 3DL5A 5ECCA 1RD7A 1D1GA 2BLBA 3D84X 1DIUA 3GHCA 1HFRA 1DLSA 5DXVA 1DHJA 1DRHA 4EIGA 1RX8A 4DPDA 5HQZA 1RX2A 3FRFX 4OR7A 3SGYA 2FZJA 3IA5A 4DPHA 3JW5A 2L28A 1DG8A 1RX9A 1J3KA 1RC4A 4KM2A 1VDRA 1DREA 3EELA 4XE6X 3NZAX 4KLXA 1LY3A 4PTJA 3FQCA 2W3AA 1DR2A 4PTHA 1DYRA 5CC9A 1IA3A 2D5NA 1RH3A 4Q0EA 3NZCX 1U70A 4HOFA 5HSUA 4DP3A 4G3MA 3QYOA 3KY8A 1JOLA 3FYWX 4KFJA 3NRRA 4X5GA 4QI9A 4G8ZX 4QJZD 3IROA 4P66A 5FDAA 3DL6A 3FREX 3DFRA 5U27A 3NXTA 3RG9A 4EILA 3EEKA 1RA9A 3SA1A 2W9HA 3IRNA 4H95A 4EJ1A 4QLEA 2W3WA 3QL0A 3OCHA 2W3VA 3GHWA 1KLKA 4Q0DA 1ZDRA 3SRSX 4XT6A 5JG0X 6DFRA 1RX3A 1S3VA 2GD9A 3E0BA 1DF7A 4KNEA 3SQYX 3NXOA 3NXXA 4X5FA 4KY8A 4KJKA 4Q67A 2C2SA 3QFXA 3R33A 1M7AA 3JWCA 4QLFA 1S3UA 3M09A 5ECXA 1CZ3A 1IA1A 3NXVA 1OHJA 3FQZA 4LAEX 3F0SX 4FGHA 4LEKX 1U72A 4FHBA 3SRWX 3QLRA 4H96A 1DHIA 3CLBA 3NTZA 3SH2A 4KEBA 3JW3A 3F0VX 1S3WA 3QLZA 5HI6A 1DR3A 2B3ZA 4Q6AA 4M2XA 1DYHA 3JSUA 2ZZAA 4KY4A 2AZNA 5HT5A 2O7PA 3UM6A 4QLGA 4ELHA 1MVTA 4IXFX 2FZHA 1VJ3A 3QL3A 1DG7A 3K74A 5U26A 4XT8A 3FYVX 3CSEA 3CD2A 3SRUX 1JOMA 3DRCA 4NX7A 2CIGA 3SRRX 4HOGA 4HA7A 1RX5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KGY A;  5HPB A;  4ELF A;  1DAJ A;  1DR1 A;  3F0B X;  1E26 A;  4ELG A;  2QK8 A;  3NZ9 X;  1M79 A;  1AO8 A;  4ECK A;  1HFQ A;  4H98 A;  3TQB A;  3DAU A;  2DRC A;  1RA8 A;  1DRF A;  1DR5 A;  3TD8 A;  2KGK A;  1DRA A;  3NXY A;  3NU0 A;  4QHV A;  3HJ3 A;  2H2Q A;  3FQV A;  3TQ9 A;  4FGG A;  3UM5 A;  1BOZ A;  3QYL A;  3UM8 A;  2W3M A;  4PDJ A;  3F0Q X;  7DFR A;  4ELB A;  2G6V A;  3F0U X;  1DRB A;  3GHV A;  4PSS A;  4M6J A;  4KAK A;  3L3R A;  4XRB A;  3F0X X;  3NZB X;  3S9U A;  1PD9 A;  4H97 A;  4M6L A;  5HVE A;  4KJL A;  4ELE A;  3NXR A;  1QZF A;  2W9G A;  2HM9 A;  2XW7 A;  3RO9 A;  5HF2 X;  4XT4 A;  1RX7 A;  3I8A X;  1DYI A;  1RX1 A;  1JUV A;  3F8Z A;  3EEJ A;  3D80 A;  5CCC A;  4XEC X;  1DHF A;  3KFY A;  3S3V A;  1HFP A;  8DFR A;  4PST A;  3SRQ X;  3KJS A;  1RF7 A;  3QG2 A;  2JYB A;  1RG7 A;  4X5H A;  4G95 A;  4DDR A;  4LAH X;  3SR5 X;  4X5J A;  3FQO A;  2W9S A;  3SAI A;  2FZI A;  3JTW A;  1PDB A;  4QJC A;  3ZPC A;  5HQY A;  5JA3 A;  3N0H A;  3GI2 A;  3FQF A;  2D0K A;  3QGT A;  1KMS A;  1CD2 A;  3K47 A;  4KBN A;  1DR4 A;  4M7U A;  2W9T A;  1RA2 A;  4PSY A;  1PD8 A;  3CL9 A;  3IX9 A;  3EIG A;  3TQA A;  4X5I A;  5HVB A;  3EEM A;  3NZ6 X;  4KYA A;  2W3B A;  3FRD X;  5HT4 A;  2ITH A;  1DDS A;  1IA4 A;  3IA4 A;  1J3J A;  1DDR A;  3KJR A;  1KMV A;  3DGA A;  1YHO A;  1DIS A;  1TDR A;  3HBB A;  5HUI A;  4I13 A;  1OHK A;  3FS6 A;  2LF1 A;  2ANO A;  1M78 A;  1J3I A;  3Q1H A;  2INQ A;  3M08 A;  1DYJ A;  4P68 A;  3S7A A;  3ROA A;  4HOE A;  3ZPG A;  4KL9 A;  3VCO A;  2BL9 A;  4IXE D;  3FY8 X;  3JVX A;  4XT5 A;  1RB3 A;  5EAJ A;  4KD7 A;  2OIP A;  1LUD A;  3JWM A;  3QLW A;  3EX8 A;  1DLR A;  3JWK A;  3QLX A;  1U71 A;  4P3Q A;  3F91 A;  1MVS A;  2CD2 A;  5HSR A;  3DG8 A;  3NZD A;  4HA9 A;  3OAF A;  4LAG X;  4KJJ A;  3IRM A;  1AI9 A;  1RE7 A;  3GYF A;  1LY4 A;  1RA1 A;  1SEJ A;  4DFR A;  3INV A;  3FRB X;  2BLA A;  3FL8 A;  3SA2 A;  2P4G A;  4KM0 A;  3K45 A;  1IA2 A;  4EIZ A;  1AOE A;  1RA3 A;  1S3Y A;  4M6K A;  3QLS A;  4XT7 A;  4CD2 A;  3TQ8 A;  1RX6 A;  1RX4 A;  5E8Q A;  4OSG A;  1DG5 A;  4TU5 X;  2C2T A;  1BZF A;  4RGC A;  3I3R A;  4P3R A;  2HXV A;  3QLY A;  1DR6 A;  3JWF A;  5HF0 X;  5DFR A;  3FY9 X;  1RB2 A;  1DR7 A;  3LG4 A;  4GH8 A;  3FQ0 A;  2DHF A;  3FL9 A;  3F8Y A;  4I1N A;  4NX6 A;  2BLC A;  3DAT A;  2OBC A;  3FRA X;  2ANQ A;  2HQP A;  4IXG X;  3K2H A;  4M7V A;  3DL5 A;  5ECC A;  1RD7 A;  1D1G A;  2BLB A;  3D84 X;  1DIU A;  3GHC A;  1HFR A;  1DLS A;  5DXV A;  1DHJ A;  1DRH A;  4EIG A;  1RX8 A;  4DPD A;  5HQZ A;  1RX2 A;  3FRF X;  4OR7 A;  3SGY A;  2FZJ A;  3IA5 A;  4DPH A;  3JW5 A;  2L28 A;  1DG8 A;  1RX9 A;  1J3K A;  1RC4 A;  4KM2 A;  1VDR A;  1DRE A;  3EEL A;  4XE6 X;  3NZA X;  4KLX A;  1LY3 A;  4PTJ A;  3FQC A;  2W3A A;  1DR2 A;  4PTH A;  1DYR A;  5CC9 A;  1IA3 A;  2D5N A;  1RH3 A;  4Q0E A;  3NZC X;  1U70 A;  4HOF A;  5HSU A;  4DP3 A;  4G3M A;  3QYO A;  3KY8 A;  1JOL A;  3FYW X;  4KFJ A;  3NRR A;  4X5G A;  4QI9 A;  4G8Z X;  4QJZ D;  3IRO A;  4P66 A;  5FDA A;  3DL6 A;  3FRE X;  3DFR A;  5U27 A;  3NXT A;  3RG9 A;  4EIL A;  3EEK A;  1RA9 A;  3SA1 A;  2W9H A;  3IRN A;  4H95 A;  4EJ1 A;  4QLE A;  2W3W A;  3QL0 A;  3OCH A;  2W3V A;  3GHW A;  1KLK A;  4Q0D A;  1ZDR A;  3SRS X;  4XT6 A;  5JG0 X;  6DFR A;  1RX3 A;  1S3V A;  2GD9 A;  3E0B A;  1DF7 A;  4KNE A;  3SQY X;  3NXO A;  3NXX A;  4X5F A;  4KY8 A;  4KJK A;  4Q67 A;  2C2S A;  3QFX A;  3R33 A;  1M7A A;  3JWC A;  4QLF A;  1S3U A;  3M09 A;  5ECX A;  1CZ3 A;  1IA1 A;  3NXV A;  1OHJ A;  3FQZ A;  4LAE X;  3F0S X;  4FGH A;  4LEK X;  1U72 A;  4FHB A;  3SRW X;  3QLR A;  4H96 A;  1DHI A;  3CLB A;  3NTZ A;  3SH2 A;  4KEB A;  3JW3 A;  3F0V X;  1S3W A;  3QLZ A;  5HI6 A;  1DR3 A;  2B3Z A;  4Q6A A;  4M2X A;  1DYH A;  3JSU A;  2ZZA A;  4KY4 A;  2AZN A;  5HT5 A;  2O7P A;  3UM6 A;  4QLG A;  4ELH A;  1MVT A;  4IXF X;  2FZH A;  1VJ3 A;  3QL3 A;  1DG7 A;  3K74 A;  5U26 A;  4XT8 A;  3FYV X;  3CSE A;  3CD2 A;  3SRU X;  1JOM A;  3DRC A;  4NX7 A;  2CIG A;  3SRR X;  4HOG A;  4HA7 A;  1RX5 A; 
#chains in the Genus database with same CATH topology
 3KGY A;  5HPB A;  4ELF A;  1DAJ A;  1DR1 A;  3F0B X;  1E26 A;  4ELG A;  2QK8 A;  3NZ9 X;  1M79 A;  1AO8 A;  4ECK A;  1HFQ A;  4H98 A;  3TQB A;  3DAU A;  2DRC A;  1RA8 A;  1DRF A;  1DR5 A;  3TD8 A;  2KGK A;  1DRA A;  3NXY A;  3NU0 A;  4QHV A;  3HJ3 A;  2H2Q A;  3FQV A;  3TQ9 A;  4FGG A;  3UM5 A;  1BOZ A;  3QYL A;  3UM8 A;  2W3M A;  4PDJ A;  3F0Q X;  7DFR A;  4ELB A;  2G6V A;  3F0U X;  1DRB A;  3GHV A;  4PSS A;  4M6J A;  4KAK A;  3L3R A;  4XRB A;  3F0X X;  3NZB X;  3S9U A;  1PD9 A;  4H97 A;  4M6L A;  5HVE A;  4KJL A;  4ELE A;  3NXR A;  1QZF A;  2W9G A;  2HM9 A;  2XW7 A;  3RO9 A;  5HF2 X;  4XT4 A;  1RX7 A;  3I8A X;  1DYI A;  1RX1 A;  1JUV A;  3F8Z A;  3EEJ A;  3D80 A;  5CCC A;  4XEC X;  1DHF A;  3KFY A;  3S3V A;  1HFP A;  8DFR A;  4PST A;  3SRQ X;  3KJS A;  1RF7 A;  3QG2 A;  2JYB A;  1RG7 A;  4X5H A;  4G95 A;  4DDR A;  4LAH X;  3SR5 X;  4X5J A;  3FQO A;  2W9S A;  3SAI A;  2FZI A;  3JTW A;  1PDB A;  4QJC A;  3ZPC A;  5HQY A;  5JA3 A;  3N0H A;  3GI2 A;  3FQF A;  2D0K A;  3QGT A;  1KMS A;  1CD2 A;  3K47 A;  4KBN A;  1DR4 A;  4M7U A;  2W9T A;  1RA2 A;  4PSY A;  1PD8 A;  3CL9 A;  3IX9 A;  3EIG A;  3TQA A;  4X5I A;  5HVB A;  3EEM A;  3NZ6 X;  4KYA A;  2W3B A;  3FRD X;  5HT4 A;  2ITH A;  1DDS A;  1IA4 A;  3IA4 A;  1J3J A;  1DDR A;  3KJR A;  1KMV A;  3DGA A;  1YHO A;  1DIS A;  1TDR A;  3HBB A;  5HUI A;  4I13 A;  1OHK A;  3FS6 A;  2LF1 A;  2ANO A;  1M78 A;  1J3I A;  3Q1H A;  2INQ A;  3M08 A;  1DYJ A;  4P68 A;  3S7A A;  3ROA A;  4HOE A;  3ZPG A;  4KL9 A;  3VCO A;  2BL9 A;  4IXE D;  3FY8 X;  3JVX A;  4XT5 A;  1RB3 A;  5EAJ A;  4KD7 A;  2OIP A;  1LUD A;  3JWM A;  3QLW A;  3EX8 A;  1DLR A;  3JWK A;  3QLX A;  1U71 A;  4P3Q A;  3F91 A;  1MVS A;  2CD2 A;  5HSR A;  3DG8 A;  3NZD A;  4HA9 A;  3OAF A;  4LAG X;  4KJJ A;  3IRM A;  1AI9 A;  1RE7 A;  3GYF A;  1LY4 A;  1RA1 A;  1SEJ A;  4DFR A;  3INV A;  3FRB X;  2BLA A;  3FL8 A;  3SA2 A;  2P4G A;  4KM0 A;  3K45 A;  1IA2 A;  4EIZ A;  1AOE A;  1RA3 A;  1S3Y A;  4M6K A;  3QLS A;  4XT7 A;  4CD2 A;  3TQ8 A;  1RX6 A;  1RX4 A;  5E8Q A;  4OSG A;  1DG5 A;  4TU5 X;  2C2T A;  1BZF A;  4RGC A;  3I3R A;  4P3R A;  2HXV A;  3QLY A;  1DR6 A;  3JWF A;  5HF0 X;  5DFR A;  3FY9 X;  1RB2 A;  1DR7 A;  3LG4 A;  4GH8 A;  3FQ0 A;  2DHF A;  3FL9 A;  3F8Y A;  4I1N A;  4NX6 A;  2BLC A;  3DAT A;  2OBC A;  3FRA X;  2ANQ A;  2HQP A;  4IXG X;  3K2H A;  4M7V A;  3DL5 A;  5ECC A;  1RD7 A;  1D1G A;  2BLB A;  3D84 X;  1DIU A;  3GHC A;  1HFR A;  1DLS A;  5DXV A;  1DHJ A;  1DRH A;  4EIG A;  1RX8 A;  4DPD A;  5HQZ A;  1RX2 A;  3FRF X;  4OR7 A;  3SGY A;  2FZJ A;  3IA5 A;  4DPH A;  3JW5 A;  2L28 A;  1DG8 A;  1RX9 A;  1J3K A;  1RC4 A;  4KM2 A;  1VDR A;  1DRE A;  3EEL A;  4XE6 X;  3NZA X;  4KLX A;  1LY3 A;  4PTJ A;  3FQC A;  2W3A A;  1DR2 A;  4PTH A;  1DYR A;  5CC9 A;  1IA3 A;  2D5N A;  1RH3 A;  4Q0E A;  3NZC X;  1U70 A;  4HOF A;  5HSU A;  4DP3 A;  4G3M A;  3QYO A;  3KY8 A;  1JOL A;  3FYW X;  4KFJ A;  3NRR A;  4X5G A;  4QI9 A;  4G8Z X;  4QJZ D;  3IRO A;  4P66 A;  5FDA A;  3DL6 A;  3FRE X;  3DFR A;  5U27 A;  3NXT A;  3RG9 A;  4EIL A;  3EEK A;  1RA9 A;  3SA1 A;  2W9H A;  3IRN A;  4H95 A;  4EJ1 A;  4QLE A;  2W3W A;  3QL0 A;  3OCH A;  2W3V A;  3GHW A;  1KLK A;  4Q0D A;  1ZDR A;  3SRS X;  4XT6 A;  5JG0 X;  6DFR A;  1RX3 A;  1S3V A;  2GD9 A;  3E0B A;  1DF7 A;  4KNE A;  3SQY X;  3NXO A;  3NXX A;  4X5F A;  4KY8 A;  4KJK A;  4Q67 A;  2C2S A;  3QFX A;  3R33 A;  1M7A A;  3JWC A;  4QLF A;  1S3U A;  3M09 A;  5ECX A;  1CZ3 A;  1IA1 A;  3NXV A;  1OHJ A;  3FQZ A;  4LAE X;  3F0S X;  4FGH A;  4LEK X;  1U72 A;  4FHB A;  3SRW X;  3QLR A;  4H96 A;  1DHI A;  3CLB A;  3NTZ A;  3SH2 A;  4KEB A;  3JW3 A;  3F0V X;  1S3W A;  3QLZ A;  5HI6 A;  1DR3 A;  2B3Z A;  4Q6A A;  4M2X A;  1DYH A;  3JSU A;  2ZZA A;  4KY4 A;  2AZN A;  5HT5 A;  2O7P A;  3UM6 A;  4QLG A;  4ELH A;  1MVT A;  4IXF X;  2FZH A;  1VJ3 A;  3QL3 A;  1DG7 A;  3K74 A;  5U26 A;  4XT8 A;  3FYV X;  3CSE A;  3CD2 A;  3SRU X;  1JOM A;  3DRC A;  4NX7 A;  2CIG A;  3SRR X;  4HOG A;  4HA7 A;  1RX5 A; 
#chains in the Genus database with same CATH homology
 3KGY A;  5HPB A;  4ELF A;  1DAJ A;  1DR1 A;  3F0B X;  1E26 A;  4ELG A;  2QK8 A;  3NZ9 X;  1M79 A;  1AO8 A;  4ECK A;  1HFQ A;  4H98 A;  3TQB A;  3DAU A;  2DRC A;  1RA8 A;  1DRF A;  1DR5 A;  3TD8 A;  2KGK A;  1DRA A;  3NXY A;  3NU0 A;  4QHV A;  3HJ3 A;  2H2Q A;  3FQV A;  3TQ9 A;  4FGG A;  3UM5 A;  1BOZ A;  3QYL A;  3UM8 A;  2W3M A;  4PDJ A;  3F0Q X;  7DFR A;  4ELB A;  2G6V A;  3F0U X;  1DRB A;  3GHV A;  4PSS A;  4M6J A;  4KAK A;  3L3R A;  4XRB A;  3F0X X;  3NZB X;  3S9U A;  1PD9 A;  4H97 A;  4M6L A;  5HVE A;  4KJL A;  4ELE A;  3NXR A;  1QZF A;  2W9G A;  2HM9 A;  2XW7 A;  3RO9 A;  5HF2 X;  4XT4 A;  1RX7 A;  3I8A X;  1DYI A;  1RX1 A;  1JUV A;  3F8Z A;  3EEJ A;  3D80 A;  5CCC A;  4XEC X;  1DHF A;  3KFY A;  3S3V A;  1HFP A;  8DFR A;  4PST A;  3SRQ X;  3KJS A;  1RF7 A;  3QG2 A;  2JYB A;  1RG7 A;  4X5H A;  4G95 A;  4DDR A;  4LAH X;  3SR5 X;  4X5J A;  3FQO A;  2W9S A;  3SAI A;  2FZI A;  3JTW A;  1PDB A;  4QJC A;  3ZPC A;  5HQY A;  5JA3 A;  3N0H A;  3GI2 A;  3FQF A;  2D0K A;  3QGT A;  1KMS A;  1CD2 A;  3K47 A;  4KBN A;  1DR4 A;  4M7U A;  2W9T A;  1RA2 A;  4PSY A;  1PD8 A;  3CL9 A;  3IX9 A;  3EIG A;  3TQA A;  4X5I A;  5HVB A;  3EEM A;  3NZ6 X;  4KYA A;  2W3B A;  3FRD X;  5HT4 A;  2ITH A;  1DDS A;  1IA4 A;  3IA4 A;  1J3J A;  1DDR A;  3KJR A;  1KMV A;  3DGA A;  1YHO A;  1DIS A;  1TDR A;  3HBB A;  5HUI A;  4I13 A;  1OHK A;  3FS6 A;  2LF1 A;  2ANO A;  1M78 A;  1J3I A;  3Q1H A;  2INQ A;  3M08 A;  1DYJ A;  4P68 A;  3S7A A;  3ROA A;  4HOE A;  3ZPG A;  4KL9 A;  3VCO A;  2BL9 A;  4IXE D;  3FY8 X;  3JVX A;  4XT5 A;  1RB3 A;  5EAJ A;  4KD7 A;  2OIP A;  1LUD A;  3JWM A;  3QLW A;  3EX8 A;  1DLR A;  3JWK A;  3QLX A;  1U71 A;  4P3Q A;  3F91 A;  1MVS A;  2CD2 A;  5HSR A;  3DG8 A;  3NZD A;  4HA9 A;  3OAF A;  4LAG X;  4KJJ A;  3IRM A;  1AI9 A;  1RE7 A;  3GYF A;  1LY4 A;  1RA1 A;  1SEJ A;  4DFR A;  3INV A;  3FRB X;  2BLA A;  3FL8 A;  3SA2 A;  2P4G A;  4KM0 A;  3K45 A;  1IA2 A;  4EIZ A;  1AOE A;  1RA3 A;  1S3Y A;  4M6K A;  3QLS A;  4XT7 A;  4CD2 A;  3TQ8 A;  1RX6 A;  1RX4 A;  5E8Q A;  4OSG A;  1DG5 A;  4TU5 X;  2C2T A;  1BZF A;  4RGC A;  3I3R A;  4P3R A;  2HXV A;  3QLY A;  1DR6 A;  3JWF A;  5HF0 X;  5DFR A;  3FY9 X;  1RB2 A;  1DR7 A;  3LG4 A;  4GH8 A;  3FQ0 A;  2DHF A;  3FL9 A;  3F8Y A;  4I1N A;  4NX6 A;  2BLC A;  3DAT A;  2OBC A;  3FRA X;  2ANQ A;  2HQP A;  4IXG X;  3K2H A;  4M7V A;  3DL5 A;  5ECC A;  1RD7 A;  1D1G A;  2BLB A;  3D84 X;  1DIU A;  3GHC A;  1HFR A;  1DLS A;  5DXV A;  1DHJ A;  1DRH A;  4EIG A;  1RX8 A;  4DPD A;  5HQZ A;  1RX2 A;  3FRF X;  4OR7 A;  3SGY A;  2FZJ A;  3IA5 A;  4DPH A;  3JW5 A;  2L28 A;  1DG8 A;  1RX9 A;  1J3K A;  1RC4 A;  4KM2 A;  1VDR A;  1DRE A;  3EEL A;  4XE6 X;  3NZA X;  4KLX A;  1LY3 A;  4PTJ A;  3FQC A;  2W3A A;  1DR2 A;  4PTH A;  1DYR A;  5CC9 A;  1IA3 A;  2D5N A;  1RH3 A;  4Q0E A;  3NZC X;  1U70 A;  4HOF A;  5HSU A;  4DP3 A;  4G3M A;  3QYO A;  3KY8 A;  1JOL A;  3FYW X;  4KFJ A;  3NRR A;  4X5G A;  4QI9 A;  4G8Z X;  4QJZ D;  3IRO A;  4P66 A;  5FDA A;  3DL6 A;  3FRE X;  3DFR A;  5U27 A;  3NXT A;  3RG9 A;  4EIL A;  3EEK A;  1RA9 A;  3SA1 A;  2W9H A;  3IRN A;  4H95 A;  4EJ1 A;  4QLE A;  2W3W A;  3QL0 A;  3OCH A;  2W3V A;  3GHW A;  1KLK A;  4Q0D A;  1ZDR A;  3SRS X;  4XT6 A;  5JG0 X;  6DFR A;  1RX3 A;  1S3V A;  2GD9 A;  3E0B A;  1DF7 A;  4KNE A;  3SQY X;  3NXO A;  3NXX A;  4X5F A;  4KY8 A;  4KJK A;  4Q67 A;  2C2S A;  3QFX A;  3R33 A;  1M7A A;  3JWC A;  4QLF A;  1S3U A;  3M09 A;  5ECX A;  1CZ3 A;  1IA1 A;  3NXV A;  1OHJ A;  3FQZ A;  4LAE X;  3F0S X;  4FGH A;  4LEK X;  1U72 A;  4FHB A;  3SRW X;  3QLR A;  4H96 A;  1DHI A;  3CLB A;  3NTZ A;  3SH2 A;  4KEB A;  3JW3 A;  3F0V X;  1S3W A;  3QLZ A;  5HI6 A;  1DR3 A;  2B3Z A;  4Q6A A;  4M2X A;  1DYH A;  3JSU A;  2ZZA A;  4KY4 A;  2AZN A;  5HT5 A;  2O7P A;  3UM6 A;  4QLG A;  4ELH A;  1MVT A;  4IXF X;  2FZH A;  1VJ3 A;  3QL3 A;  1DG7 A;  3K74 A;  5U26 A;  4XT8 A;  3FYV X;  3CSE A;  3CD2 A;  3SRU X;  1JOM A;  3DRC A;  4NX7 A;  2CIG A;  3SRR X;  4HOG A;  4HA7 A;  1RX5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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