2DHFA

Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazofolate
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
182
structure length
182
Chain Sequence
LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
source organism Homo sapiens
publication title Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate.
pubmed doi rcsb
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 51
structure length 182
sequence length 182
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 1989-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 2dhfA00
2W3WA 3F0XX 3IA5A 3GHVA 1DR5A 1RX4A 3S7AA 1RX2A 3IA4A 3QL3A 2W9SA 5ECXA 1DR3A 4IXFX 1OHKA 1S3YA 3NZCX 4KAKA 4NX6A 1RX9A 3FL8A 5HT4A 5HF2X 3KJRA 1DG5A 1RX7A 2FZHA 3FREX 2W3BA 4X5FA 2B3ZA 4GH8A 1VJ3A 4G95A 4XT4A 3CD2A 1OHJA 1AOEA 1D1GA 1LY4A 4KNEA 4P68A 3GHCA 3N0HA 1LUDA 1U71A 1RA8A 4HOGA 1DG8A 3TQ9A 4DPHA 1RX6A 2ANQA 2BLBA 1M7AA 4EJ1A 2C2SA 3K2HA 3FQ0A 4G8ZX 5HF0X 1DISA 3JW3A 3SRQX 1S3UA 3FYWX 1J3KA 1DIUA 1DYIA 1DLSA 2KGKA 5U26A 4P3RA 4P3QA 2DHFA 3GYFA 4XE6X 4QLEA 4PTHA 1IA2A 3VCOA 4QLFA 2W3VA 4HA7A 1DREA 3DL6A 4FGHA 3R33A 3IRMA 4KLXA 3M08A 4X5JA 5DXVA 2HM9A 1DF7A 2INQA 3NZ9X 4PSTA 1RA1A 1KMVA 4QLGA 3QLSA 3QLWA 4IXED 1AI9A 3F8ZA 2XW7A 3EEJA 2W9GA 3FS6A 3JTWA 3F91A 1PD9A 4LEKX 1DHIA 4Q0DA 1RG7A 3D80A 1TDRA 5E8QA 1J3JA 3GHWA 4KM2A 1RX5A 3SH2A 3I3RA 3EIGA 2AZNA 3F0VX 3NTZA 4QJZD 1RX1A 2GD9A 4PSSA 3FQCA 5HVBA 3FRBX 4EILA 3JWKA 3DL5A 3EEMA 4LAEX 4M7VA 1DRAA 1DRHA 5HI6A 4X5HA 1CZ3A 1DLRA 3INVA 1MVTA 1HFRA 2QK8A 4QHVA 2G6VA 1DR6A 3NZDA 4PDJA 1RB2A 5FDAA 3QL0A 4X5IA 1JOLA 1RB3A 3SQYX 3DGAA 3ROAA 1DRBA 4Q67A 4ELEA 1VDRA 1RX8A 1RX3A 4I13A 1DDRA 1DR4A 4ECKA 4RGCA 3JWMA 1SEJA 3SRUX 4KM0A 5DFRA 1DRFA 3FL9A 1DHJA 2BL9A 4G3MA 2ANOA 3NZBX 4KJLA 5HQZA 4ELGA 3QYOA 5HPBA 4KJJA 5JG0X 3QLXA 2H2QA 4HOEA 4M7UA 1ZDRA 3NXYA 1DR2A 4KD7A 1DDSA 3DRCA 3NXRA 3JW5A 4CD2A 4ELFA 4M2XA 1DHFA 4KYAA 3Q1HA 4EIGA 1MVSA 4OR7A 3CL9A 2W9TA 4H96A 4IXGX 2D5NA 4Q6AA 1BOZA 3SA2A 3QG2A 4H95A 4M6KA 8DFRA 4I1NA 4DP3A 1S3WA 1DYRA 1E26A 1RH3A 4XT5A 4HOFA 4DPDA 1RA3A 3NXVA 3F0BX 3FY9X 3DATA 3EELA 1DAJA 1JOMA 2BLCA 3NZAX 3QYLA 3EX8A 2OBCA 5HUIA 3ZPCA 3DG8A 3FYVX 5U27A 4ELHA 1IA1A 2W9HA 3SA1A 1AO8A 3FQOA 3S9UA 2ITHA 3JWCA 3DAUA 3HBBA 1RA9A 4KFJA 3ZPGA 4FGGA 3FRFX 3FQZA 3JWFA 5CC9A 1DYHA 3SAIA 2OIPA 3IRNA 2W3MA 3I8AX 3NXXA 5HVEA 4DFRA 3UM8A 2O7PA 3E0BA 3M09A 2C2TA 1J3IA 2CD2A 2BLAA 4XECX 3FRDX 3K74A 1HFQA 4XT7A 1KMSA 3FRAX 4KY8A 3NXTA 3QGTA 3F0SX 3KJSA 3CSEA 1YHOA 3QLYA 4PSYA 3JVXA 3TQBA 1RA2A 1QZFA 4KBNA 4H97A 1JUVA 4M6LA 2LF1A 4KL9A 3FY8X 4QJCA 1M78A 3RG9A 3LG4A 4H98A 1DR1A 3QFXA 3TQ8A 3SRRX 2FZJA 1HFPA 3SRSX 5EAJA 4X5GA 3S3VA 4KY4A 4HA9A 4OSGA 5ECCA 3OCHA 1RC4A 4Q0EA 1BZFA 2JYBA 3KGYA 3QLRA 1RF7A 3NRRA 1CD2A 4EIZA 1U72A 2P4GA 5JA3A 4FHBA 4XT6A 2FZIA 3SGYA 1RE7A 2HXVA 3GI2A 3TD8A 3IROA 3SRWX 4QI9A 1KLKA 3EEKA 5CCCA 1RD7A 3D84X 2L28A 3DFRA 2HQPA 3NU0A 3OAFA 2D0KA 3K47A 3NXOA 4M6JA 1M79A 4PTJA 3L3RA 1S3VA 3K45A 4XRBA 2W3AA 3QLZA 3FQFA 2ZZAA 6DFRA 2DRCA 3HJ3A 1LY3A 4NX7A 4KEBA 1DG7A 1DR7A 1IA4A 2CIGA 5HSUA 3JSUA 1IA3A 4DDRA 1U70A 4XT8A 3NZ6X 3F0QX 1DYJA 3KY8A 3UM6A 5HQYA 5HT5A 1PDBA 3FQVA 4ELBA 3UM5A 3F0UX 4LAHX 4TU5X 1PD8A 3TQAA 3IX9A 4P66A 3F8YA 3KFYA 3SR5X 4KJKA 3RO9A 5HSRA 4LAGX 7DFRA 3CLBA
chains in the Genus database with same CATH superfamily
2W3WA 3F0XX 3IA5A 3GHVA 1DR5A 1RX4A 3S7AA 1RX2A 3IA4A 3QL3A 2W9SA 5ECXA 1DR3A 4IXFX 1OHKA 1S3YA 3NZCX 4KAKA 4NX6A 1RX9A 3FL8A 5HT4A 5HF2X 3KJRA 1DG5A 1RX7A 2FZHA 3FREX 2W3BA 4X5FA 2B3ZA 4GH8A 1VJ3A 4G95A 4XT4A 3CD2A 1OHJA 1AOEA 1D1GA 1LY4A 4KNEA 4P68A 3GHCA 3N0HA 1LUDA 1U71A 1RA8A 4HOGA 1DG8A 3TQ9A 4DPHA 1RX6A 2ANQA 2BLBA 1M7AA 4EJ1A 2C2SA 3K2HA 3FQ0A 4G8ZX 5HF0X 1DISA 3JW3A 3SRQX 1S3UA 3FYWX 1J3KA 1DIUA 1DYIA 1DLSA 2KGKA 5U26A 4P3RA 4P3QA 2DHFA 3GYFA 4XE6X 4QLEA 4PTHA 1IA2A 3VCOA 4QLFA 2W3VA 4HA7A 1DREA 3DL6A 4FGHA 3R33A 3IRMA 4KLXA 3M08A 4X5JA 5DXVA 2HM9A 1DF7A 2INQA 3NZ9X 4PSTA 1RA1A 1KMVA 4QLGA 3QLSA 3QLWA 4IXED 1AI9A 3F8ZA 2XW7A 3EEJA 2W9GA 3FS6A 3JTWA 3F91A 1PD9A 4LEKX 1DHIA 4Q0DA 1RG7A 3D80A 1TDRA 5E8QA 1J3JA 3GHWA 4KM2A 1RX5A 3SH2A 3I3RA 3EIGA 2AZNA 3F0VX 3NTZA 4QJZD 1RX1A 2GD9A 4PSSA 3FQCA 5HVBA 3FRBX 4EILA 3JWKA 3DL5A 3EEMA 4LAEX 4M7VA 1DRAA 1DRHA 5HI6A 4X5HA 1CZ3A 1DLRA 3INVA 1MVTA 1HFRA 2QK8A 4QHVA 2G6VA 1DR6A 3NZDA 4PDJA 1RB2A 5FDAA 3QL0A 4X5IA 1JOLA 1RB3A 3SQYX 3DGAA 3ROAA 1DRBA 4Q67A 4ELEA 1VDRA 1RX8A 1RX3A 4I13A 1DDRA 1DR4A 4ECKA 4RGCA 3JWMA 1SEJA 3SRUX 4KM0A 5DFRA 1DRFA 3FL9A 1DHJA 2BL9A 4G3MA 2ANOA 3NZBX 4KJLA 5HQZA 4ELGA 3QYOA 5HPBA 4KJJA 5JG0X 3QLXA 2H2QA 4HOEA 4M7UA 1ZDRA 3NXYA 1DR2A 4KD7A 1DDSA 3DRCA 3NXRA 3JW5A 4CD2A 4ELFA 4M2XA 1DHFA 4KYAA 3Q1HA 4EIGA 1MVSA 4OR7A 3CL9A 2W9TA 4H96A 4IXGX 2D5NA 4Q6AA 1BOZA 3SA2A 3QG2A 4H95A 4M6KA 8DFRA 4I1NA 4DP3A 1S3WA 1DYRA 1E26A 1RH3A 4XT5A 4HOFA 4DPDA 1RA3A 3NXVA 3F0BX 3FY9X 3DATA 3EELA 1DAJA 1JOMA 2BLCA 3NZAX 3QYLA 3EX8A 2OBCA 5HUIA 3ZPCA 3DG8A 3FYVX 5U27A 4ELHA 1IA1A 2W9HA 3SA1A 1AO8A 3FQOA 3S9UA 2ITHA 3JWCA 3DAUA 3HBBA 1RA9A 4KFJA 3ZPGA 4FGGA 3FRFX 3FQZA 3JWFA 5CC9A 1DYHA 3SAIA 2OIPA 3IRNA 2W3MA 3I8AX 3NXXA 5HVEA 4DFRA 3UM8A 2O7PA 3E0BA 3M09A 2C2TA 1J3IA 2CD2A 2BLAA 4XECX 3FRDX 3K74A 1HFQA 4XT7A 1KMSA 3FRAX 4KY8A 3NXTA 3QGTA 3F0SX 3KJSA 3CSEA 1YHOA 3QLYA 4PSYA 3JVXA 3TQBA 1RA2A 1QZFA 4KBNA 4H97A 1JUVA 4M6LA 2LF1A 4KL9A 3FY8X 4QJCA 1M78A 3RG9A 3LG4A 4H98A 1DR1A 3QFXA 3TQ8A 3SRRX 2FZJA 1HFPA 3SRSX 5EAJA 4X5GA 3S3VA 4KY4A 4HA9A 4OSGA 5ECCA 3OCHA 1RC4A 4Q0EA 1BZFA 2JYBA 3KGYA 3QLRA 1RF7A 3NRRA 1CD2A 4EIZA 1U72A 2P4GA 5JA3A 4FHBA 4XT6A 2FZIA 3SGYA 1RE7A 2HXVA 3GI2A 3TD8A 3IROA 3SRWX 4QI9A 1KLKA 3EEKA 5CCCA 1RD7A 3D84X 2L28A 3DFRA 2HQPA 3NU0A 3OAFA 2D0KA 3K47A 3NXOA 4M6JA 1M79A 4PTJA 3L3RA 1S3VA 3K45A 4XRBA 2W3AA 3QLZA 3FQFA 2ZZAA 6DFRA 2DRCA 3HJ3A 1LY3A 4NX7A 4KEBA 1DG7A 1DR7A 1IA4A 2CIGA 5HSUA 3JSUA 1IA3A 4DDRA 1U70A 4XT8A 3NZ6X 3F0QX 1DYJA 3KY8A 3UM6A 5HQYA 5HT5A 1PDBA 3FQVA 4ELBA 3UM5A 3F0UX 4LAHX 4TU5X 1PD8A 3TQAA 3IX9A 4P66A 3F8YA 3KFYA 3SR5X 4KJKA 3RO9A 5HSRA 4LAGX 7DFRA 3CLBA
chains in the Genus database with same CATH topology
2W3WA 3F0XX 3IA5A 3GHVA 1DR5A 1RX4A 3S7AA 1RX2A 3IA4A 3QL3A 2W9SA 5ECXA 1DR3A 4IXFX 1OHKA 1S3YA 3NZCX 4KAKA 4NX6A 1RX9A 3FL8A 5HT4A 5HF2X 3KJRA 1DG5A 1RX7A 2FZHA 3FREX 2W3BA 4X5FA 2B3ZA 4GH8A 1VJ3A 4G95A 4XT4A 3CD2A 1OHJA 1AOEA 1D1GA 1LY4A 4KNEA 4P68A 3GHCA 3N0HA 1LUDA 1U71A 1RA8A 4HOGA 1DG8A 3TQ9A 4DPHA 1RX6A 2ANQA 2BLBA 1M7AA 4EJ1A 2C2SA 3K2HA 3FQ0A 4G8ZX 5HF0X 1DISA 3JW3A 3SRQX 1S3UA 3FYWX 1J3KA 1DIUA 1DYIA 1DLSA 2KGKA 5U26A 4P3RA 4P3QA 2DHFA 3GYFA 4XE6X 4QLEA 4PTHA 1IA2A 3VCOA 4QLFA 2W3VA 4HA7A 1DREA 3DL6A 4FGHA 3R33A 3IRMA 4KLXA 3M08A 4X5JA 5DXVA 2HM9A 1DF7A 2INQA 3NZ9X 4PSTA 1RA1A 1KMVA 4QLGA 3QLSA 3QLWA 4IXED 1AI9A 3F8ZA 2XW7A 3EEJA 2W9GA 3FS6A 3JTWA 3F91A 1PD9A 4LEKX 1DHIA 4Q0DA 1RG7A 3D80A 1TDRA 5E8QA 1J3JA 3GHWA 4KM2A 1RX5A 3SH2A 3I3RA 3EIGA 2AZNA 3F0VX 3NTZA 4QJZD 1RX1A 2GD9A 4PSSA 3FQCA 5HVBA 3FRBX 4EILA 3JWKA 3DL5A 3EEMA 4LAEX 4M7VA 1DRAA 1DRHA 5HI6A 4X5HA 1CZ3A 1DLRA 3INVA 1MVTA 1HFRA 2QK8A 4QHVA 2G6VA 1DR6A 3NZDA 4PDJA 1RB2A 5FDAA 3QL0A 4X5IA 1JOLA 1RB3A 3SQYX 3DGAA 3ROAA 1DRBA 4Q67A 4ELEA 1VDRA 1RX8A 1RX3A 4I13A 1DDRA 1DR4A 4ECKA 4RGCA 3JWMA 1SEJA 3SRUX 4KM0A 5DFRA 1DRFA 3FL9A 1DHJA 2BL9A 4G3MA 2ANOA 3NZBX 4KJLA 5HQZA 4ELGA 3QYOA 5HPBA 4KJJA 5JG0X 3QLXA 2H2QA 4HOEA 4M7UA 1ZDRA 3NXYA 1DR2A 4KD7A 1DDSA 3DRCA 3NXRA 3JW5A 4CD2A 4ELFA 4M2XA 1DHFA 4KYAA 3Q1HA 4EIGA 1MVSA 4OR7A 3CL9A 2W9TA 4H96A 4IXGX 2D5NA 4Q6AA 1BOZA 3SA2A 3QG2A 4H95A 4M6KA 8DFRA 4I1NA 4DP3A 1S3WA 1DYRA 1E26A 1RH3A 4XT5A 4HOFA 4DPDA 1RA3A 3NXVA 3F0BX 3FY9X 3DATA 3EELA 1DAJA 1JOMA 2BLCA 3NZAX 3QYLA 3EX8A 2OBCA 5HUIA 3ZPCA 3DG8A 3FYVX 5U27A 4ELHA 1IA1A 2W9HA 3SA1A 1AO8A 3FQOA 3S9UA 2ITHA 3JWCA 3DAUA 3HBBA 1RA9A 4KFJA 3ZPGA 4FGGA 3FRFX 3FQZA 3JWFA 5CC9A 1DYHA 3SAIA 2OIPA 3IRNA 2W3MA 3I8AX 3NXXA 5HVEA 4DFRA 3UM8A 2O7PA 3E0BA 3M09A 2C2TA 1J3IA 2CD2A 2BLAA 4XECX 3FRDX 3K74A 1HFQA 4XT7A 1KMSA 3FRAX 4KY8A 3NXTA 3QGTA 3F0SX 3KJSA 3CSEA 1YHOA 3QLYA 4PSYA 3JVXA 3TQBA 1RA2A 1QZFA 4KBNA 4H97A 1JUVA 4M6LA 2LF1A 4KL9A 3FY8X 4QJCA 1M78A 3RG9A 3LG4A 4H98A 1DR1A 3QFXA 3TQ8A 3SRRX 2FZJA 1HFPA 3SRSX 5EAJA 4X5GA 3S3VA 4KY4A 4HA9A 4OSGA 5ECCA 3OCHA 1RC4A 4Q0EA 1BZFA 2JYBA 3KGYA 3QLRA 1RF7A 3NRRA 1CD2A 4EIZA 1U72A 2P4GA 5JA3A 4FHBA 4XT6A 2FZIA 3SGYA 1RE7A 2HXVA 3GI2A 3TD8A 3IROA 3SRWX 4QI9A 1KLKA 3EEKA 5CCCA 1RD7A 3D84X 2L28A 3DFRA 2HQPA 3NU0A 3OAFA 2D0KA 3K47A 3NXOA 4M6JA 1M79A 4PTJA 3L3RA 1S3VA 3K45A 4XRBA 2W3AA 3QLZA 3FQFA 2ZZAA 6DFRA 2DRCA 3HJ3A 1LY3A 4NX7A 4KEBA 1DG7A 1DR7A 1IA4A 2CIGA 5HSUA 3JSUA 1IA3A 4DDRA 1U70A 4XT8A 3NZ6X 3F0QX 1DYJA 3KY8A 3UM6A 5HQYA 5HT5A 1PDBA 3FQVA 4ELBA 3UM5A 3F0UX 4LAHX 4TU5X 1PD8A 3TQAA 3IX9A 4P66A 3F8YA 3KFYA 3SR5X 4KJKA 3RO9A 5HSRA 4LAGX 7DFRA 3CLBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W3W A;  3F0X X;  3IA5 A;  3GHV A;  1DR5 A;  1RX4 A;  3S7A A;  1RX2 A;  3IA4 A;  3QL3 A;  2W9S A;  5ECX A;  1DR3 A;  4IXF X;  1OHK A;  1S3Y A;  3NZC X;  4KAK A;  4NX6 A;  1RX9 A;  3FL8 A;  5HT4 A;  5HF2 X;  3KJR A;  1DG5 A;  1RX7 A;  2FZH A;  3FRE X;  2W3B A;  4X5F A;  2B3Z A;  4GH8 A;  1VJ3 A;  4G95 A;  4XT4 A;  3CD2 A;  1OHJ A;  1AOE A;  1D1G A;  1LY4 A;  4KNE A;  4P68 A;  3GHC A;  3N0H A;  1LUD A;  1U71 A;  1RA8 A;  4HOG A;  1DG8 A;  3TQ9 A;  4DPH A;  1RX6 A;  2ANQ A;  2BLB A;  1M7A A;  4EJ1 A;  2C2S A;  3K2H A;  3FQ0 A;  4G8Z X;  5HF0 X;  1DIS A;  3JW3 A;  3SRQ X;  1S3U A;  3FYW X;  1J3K A;  1DIU A;  1DYI A;  1DLS A;  2KGK A;  5U26 A;  4P3R A;  4P3Q A;  2DHF A;  3GYF A;  4XE6 X;  4QLE A;  4PTH A;  1IA2 A;  3VCO A;  4QLF A;  2W3V A;  4HA7 A;  1DRE A;  3DL6 A;  4FGH A;  3R33 A;  3IRM A;  4KLX A;  3M08 A;  4X5J A;  5DXV A;  2HM9 A;  1DF7 A;  2INQ A;  3NZ9 X;  4PST A;  1RA1 A;  1KMV A;  4QLG A;  3QLS A;  3QLW A;  4IXE D;  1AI9 A;  3F8Z A;  2XW7 A;  3EEJ A;  2W9G A;  3FS6 A;  3JTW A;  3F91 A;  1PD9 A;  4LEK X;  1DHI A;  4Q0D A;  1RG7 A;  3D80 A;  1TDR A;  5E8Q A;  1J3J A;  3GHW A;  4KM2 A;  1RX5 A;  3SH2 A;  3I3R A;  3EIG A;  2AZN A;  3F0V X;  3NTZ A;  4QJZ D;  1RX1 A;  2GD9 A;  4PSS A;  3FQC A;  5HVB A;  3FRB X;  4EIL A;  3JWK A;  3DL5 A;  3EEM A;  4LAE X;  4M7V A;  1DRA A;  1DRH A;  5HI6 A;  4X5H A;  1CZ3 A;  1DLR A;  3INV A;  1MVT A;  1HFR A;  2QK8 A;  4QHV A;  2G6V A;  1DR6 A;  3NZD A;  4PDJ A;  1RB2 A;  5FDA A;  3QL0 A;  4X5I A;  1JOL A;  1RB3 A;  3SQY X;  3DGA A;  3ROA A;  1DRB A;  4Q67 A;  4ELE A;  1VDR A;  1RX8 A;  1RX3 A;  4I13 A;  1DDR A;  1DR4 A;  4ECK A;  4RGC A;  3JWM A;  1SEJ A;  3SRU X;  4KM0 A;  5DFR A;  1DRF A;  3FL9 A;  1DHJ A;  2BL9 A;  4G3M A;  2ANO A;  3NZB X;  4KJL A;  5HQZ A;  4ELG A;  3QYO A;  5HPB A;  4KJJ A;  5JG0 X;  3QLX A;  2H2Q A;  4HOE A;  4M7U A;  1ZDR A;  3NXY A;  1DR2 A;  4KD7 A;  1DDS A;  3DRC A;  3NXR A;  3JW5 A;  4CD2 A;  4ELF A;  4M2X A;  1DHF A;  4KYA A;  3Q1H A;  4EIG A;  1MVS A;  4OR7 A;  3CL9 A;  2W9T A;  4H96 A;  4IXG X;  2D5N A;  4Q6A A;  1BOZ A;  3SA2 A;  3QG2 A;  4H95 A;  4M6K A;  8DFR A;  4I1N A;  4DP3 A;  1S3W A;  1DYR A;  1E26 A;  1RH3 A;  4XT5 A;  4HOF A;  4DPD A;  1RA3 A;  3NXV A;  3F0B X;  3FY9 X;  3DAT A;  3EEL A;  1DAJ A;  1JOM A;  2BLC A;  3NZA X;  3QYL A;  3EX8 A;  2OBC A;  5HUI A;  3ZPC A;  3DG8 A;  3FYV X;  5U27 A;  4ELH A;  1IA1 A;  2W9H A;  3SA1 A;  1AO8 A;  3FQO A;  3S9U A;  2ITH A;  3JWC A;  3DAU A;  3HBB A;  1RA9 A;  4KFJ A;  3ZPG A;  4FGG A;  3FRF X;  3FQZ A;  3JWF A;  5CC9 A;  1DYH A;  3SAI A;  2OIP A;  3IRN A;  2W3M A;  3I8A X;  3NXX A;  5HVE A;  4DFR A;  3UM8 A;  2O7P A;  3E0B A;  3M09 A;  2C2T A;  1J3I A;  2CD2 A;  2BLA A;  4XEC X;  3FRD X;  3K74 A;  1HFQ A;  4XT7 A;  1KMS A;  3FRA X;  4KY8 A;  3NXT A;  3QGT A;  3F0S X;  3KJS A;  3CSE A;  1YHO A;  3QLY A;  4PSY A;  3JVX A;  3TQB A;  1RA2 A;  1QZF A;  4KBN A;  4H97 A;  1JUV A;  4M6L A;  2LF1 A;  4KL9 A;  3FY8 X;  4QJC A;  1M78 A;  3RG9 A;  3LG4 A;  4H98 A;  1DR1 A;  3QFX A;  3TQ8 A;  3SRR X;  2FZJ A;  1HFP A;  3SRS X;  5EAJ A;  4X5G A;  3S3V A;  4KY4 A;  4HA9 A;  4OSG A;  5ECC A;  3OCH A;  1RC4 A;  4Q0E A;  1BZF A;  2JYB A;  3KGY A;  3QLR A;  1RF7 A;  3NRR A;  1CD2 A;  4EIZ A;  1U72 A;  2P4G A;  5JA3 A;  4FHB A;  4XT6 A;  2FZI A;  3SGY A;  1RE7 A;  2HXV A;  3GI2 A;  3TD8 A;  3IRO A;  3SRW X;  4QI9 A;  1KLK A;  3EEK A;  5CCC A;  1RD7 A;  3D84 X;  2L28 A;  3DFR A;  2HQP A;  3NU0 A;  3OAF A;  2D0K A;  3K47 A;  3NXO A;  4M6J A;  1M79 A;  4PTJ A;  3L3R A;  1S3V A;  3K45 A;  4XRB A;  2W3A A;  3QLZ A;  3FQF A;  2ZZA A;  6DFR A;  2DRC A;  3HJ3 A;  1LY3 A;  4NX7 A;  4KEB A;  1DG7 A;  1DR7 A;  1IA4 A;  2CIG A;  5HSU A;  3JSU A;  1IA3 A;  4DDR A;  1U70 A;  4XT8 A;  3NZ6 X;  3F0Q X;  1DYJ A;  3KY8 A;  3UM6 A;  5HQY A;  5HT5 A;  1PDB A;  3FQV A;  4ELB A;  3UM5 A;  3F0U X;  4LAH X;  4TU5 X;  1PD8 A;  3TQA A;  3IX9 A;  4P66 A;  3F8Y A;  3KFY A;  3SR5 X;  4KJK A;  3RO9 A;  5HSR A;  4LAG X;  7DFR A;  3CLB A; 
#chains in the Genus database with same CATH topology
 2W3W A;  3F0X X;  3IA5 A;  3GHV A;  1DR5 A;  1RX4 A;  3S7A A;  1RX2 A;  3IA4 A;  3QL3 A;  2W9S A;  5ECX A;  1DR3 A;  4IXF X;  1OHK A;  1S3Y A;  3NZC X;  4KAK A;  4NX6 A;  1RX9 A;  3FL8 A;  5HT4 A;  5HF2 X;  3KJR A;  1DG5 A;  1RX7 A;  2FZH A;  3FRE X;  2W3B A;  4X5F A;  2B3Z A;  4GH8 A;  1VJ3 A;  4G95 A;  4XT4 A;  3CD2 A;  1OHJ A;  1AOE A;  1D1G A;  1LY4 A;  4KNE A;  4P68 A;  3GHC A;  3N0H A;  1LUD A;  1U71 A;  1RA8 A;  4HOG A;  1DG8 A;  3TQ9 A;  4DPH A;  1RX6 A;  2ANQ A;  2BLB A;  1M7A A;  4EJ1 A;  2C2S A;  3K2H A;  3FQ0 A;  4G8Z X;  5HF0 X;  1DIS A;  3JW3 A;  3SRQ X;  1S3U A;  3FYW X;  1J3K A;  1DIU A;  1DYI A;  1DLS A;  2KGK A;  5U26 A;  4P3R A;  4P3Q A;  2DHF A;  3GYF A;  4XE6 X;  4QLE A;  4PTH A;  1IA2 A;  3VCO A;  4QLF A;  2W3V A;  4HA7 A;  1DRE A;  3DL6 A;  4FGH A;  3R33 A;  3IRM A;  4KLX A;  3M08 A;  4X5J A;  5DXV A;  2HM9 A;  1DF7 A;  2INQ A;  3NZ9 X;  4PST A;  1RA1 A;  1KMV A;  4QLG A;  3QLS A;  3QLW A;  4IXE D;  1AI9 A;  3F8Z A;  2XW7 A;  3EEJ A;  2W9G A;  3FS6 A;  3JTW A;  3F91 A;  1PD9 A;  4LEK X;  1DHI A;  4Q0D A;  1RG7 A;  3D80 A;  1TDR A;  5E8Q A;  1J3J A;  3GHW A;  4KM2 A;  1RX5 A;  3SH2 A;  3I3R A;  3EIG A;  2AZN A;  3F0V X;  3NTZ A;  4QJZ D;  1RX1 A;  2GD9 A;  4PSS A;  3FQC A;  5HVB A;  3FRB X;  4EIL A;  3JWK A;  3DL5 A;  3EEM A;  4LAE X;  4M7V A;  1DRA A;  1DRH A;  5HI6 A;  4X5H A;  1CZ3 A;  1DLR A;  3INV A;  1MVT A;  1HFR A;  2QK8 A;  4QHV A;  2G6V A;  1DR6 A;  3NZD A;  4PDJ A;  1RB2 A;  5FDA A;  3QL0 A;  4X5I A;  1JOL A;  1RB3 A;  3SQY X;  3DGA A;  3ROA A;  1DRB A;  4Q67 A;  4ELE A;  1VDR A;  1RX8 A;  1RX3 A;  4I13 A;  1DDR A;  1DR4 A;  4ECK A;  4RGC A;  3JWM A;  1SEJ A;  3SRU X;  4KM0 A;  5DFR A;  1DRF A;  3FL9 A;  1DHJ A;  2BL9 A;  4G3M A;  2ANO A;  3NZB X;  4KJL A;  5HQZ A;  4ELG A;  3QYO A;  5HPB A;  4KJJ A;  5JG0 X;  3QLX A;  2H2Q A;  4HOE A;  4M7U A;  1ZDR A;  3NXY A;  1DR2 A;  4KD7 A;  1DDS A;  3DRC A;  3NXR A;  3JW5 A;  4CD2 A;  4ELF A;  4M2X A;  1DHF A;  4KYA A;  3Q1H A;  4EIG A;  1MVS A;  4OR7 A;  3CL9 A;  2W9T A;  4H96 A;  4IXG X;  2D5N A;  4Q6A A;  1BOZ A;  3SA2 A;  3QG2 A;  4H95 A;  4M6K A;  8DFR A;  4I1N A;  4DP3 A;  1S3W A;  1DYR A;  1E26 A;  1RH3 A;  4XT5 A;  4HOF A;  4DPD A;  1RA3 A;  3NXV A;  3F0B X;  3FY9 X;  3DAT A;  3EEL A;  1DAJ A;  1JOM A;  2BLC A;  3NZA X;  3QYL A;  3EX8 A;  2OBC A;  5HUI A;  3ZPC A;  3DG8 A;  3FYV X;  5U27 A;  4ELH A;  1IA1 A;  2W9H A;  3SA1 A;  1AO8 A;  3FQO A;  3S9U A;  2ITH A;  3JWC A;  3DAU A;  3HBB A;  1RA9 A;  4KFJ A;  3ZPG A;  4FGG A;  3FRF X;  3FQZ A;  3JWF A;  5CC9 A;  1DYH A;  3SAI A;  2OIP A;  3IRN A;  2W3M A;  3I8A X;  3NXX A;  5HVE A;  4DFR A;  3UM8 A;  2O7P A;  3E0B A;  3M09 A;  2C2T A;  1J3I A;  2CD2 A;  2BLA A;  4XEC X;  3FRD X;  3K74 A;  1HFQ A;  4XT7 A;  1KMS A;  3FRA X;  4KY8 A;  3NXT A;  3QGT A;  3F0S X;  3KJS A;  3CSE A;  1YHO A;  3QLY A;  4PSY A;  3JVX A;  3TQB A;  1RA2 A;  1QZF A;  4KBN A;  4H97 A;  1JUV A;  4M6L A;  2LF1 A;  4KL9 A;  3FY8 X;  4QJC A;  1M78 A;  3RG9 A;  3LG4 A;  4H98 A;  1DR1 A;  3QFX A;  3TQ8 A;  3SRR X;  2FZJ A;  1HFP A;  3SRS X;  5EAJ A;  4X5G A;  3S3V A;  4KY4 A;  4HA9 A;  4OSG A;  5ECC A;  3OCH A;  1RC4 A;  4Q0E A;  1BZF A;  2JYB A;  3KGY A;  3QLR A;  1RF7 A;  3NRR A;  1CD2 A;  4EIZ A;  1U72 A;  2P4G A;  5JA3 A;  4FHB A;  4XT6 A;  2FZI A;  3SGY A;  1RE7 A;  2HXV A;  3GI2 A;  3TD8 A;  3IRO A;  3SRW X;  4QI9 A;  1KLK A;  3EEK A;  5CCC A;  1RD7 A;  3D84 X;  2L28 A;  3DFR A;  2HQP A;  3NU0 A;  3OAF A;  2D0K A;  3K47 A;  3NXO A;  4M6J A;  1M79 A;  4PTJ A;  3L3R A;  1S3V A;  3K45 A;  4XRB A;  2W3A A;  3QLZ A;  3FQF A;  2ZZA A;  6DFR A;  2DRC A;  3HJ3 A;  1LY3 A;  4NX7 A;  4KEB A;  1DG7 A;  1DR7 A;  1IA4 A;  2CIG A;  5HSU A;  3JSU A;  1IA3 A;  4DDR A;  1U70 A;  4XT8 A;  3NZ6 X;  3F0Q X;  1DYJ A;  3KY8 A;  3UM6 A;  5HQY A;  5HT5 A;  1PDB A;  3FQV A;  4ELB A;  3UM5 A;  3F0U X;  4LAH X;  4TU5 X;  1PD8 A;  3TQA A;  3IX9 A;  4P66 A;  3F8Y A;  3KFY A;  3SR5 X;  4KJK A;  3RO9 A;  5HSR A;  4LAG X;  7DFR A;  3CLB A; 
#chains in the Genus database with same CATH homology
 2W3W A;  3F0X X;  3IA5 A;  3GHV A;  1DR5 A;  1RX4 A;  3S7A A;  1RX2 A;  3IA4 A;  3QL3 A;  2W9S A;  5ECX A;  1DR3 A;  4IXF X;  1OHK A;  1S3Y A;  3NZC X;  4KAK A;  4NX6 A;  1RX9 A;  3FL8 A;  5HT4 A;  5HF2 X;  3KJR A;  1DG5 A;  1RX7 A;  2FZH A;  3FRE X;  2W3B A;  4X5F A;  2B3Z A;  4GH8 A;  1VJ3 A;  4G95 A;  4XT4 A;  3CD2 A;  1OHJ A;  1AOE A;  1D1G A;  1LY4 A;  4KNE A;  4P68 A;  3GHC A;  3N0H A;  1LUD A;  1U71 A;  1RA8 A;  4HOG A;  1DG8 A;  3TQ9 A;  4DPH A;  1RX6 A;  2ANQ A;  2BLB A;  1M7A A;  4EJ1 A;  2C2S A;  3K2H A;  3FQ0 A;  4G8Z X;  5HF0 X;  1DIS A;  3JW3 A;  3SRQ X;  1S3U A;  3FYW X;  1J3K A;  1DIU A;  1DYI A;  1DLS A;  2KGK A;  5U26 A;  4P3R A;  4P3Q A;  2DHF A;  3GYF A;  4XE6 X;  4QLE A;  4PTH A;  1IA2 A;  3VCO A;  4QLF A;  2W3V A;  4HA7 A;  1DRE A;  3DL6 A;  4FGH A;  3R33 A;  3IRM A;  4KLX A;  3M08 A;  4X5J A;  5DXV A;  2HM9 A;  1DF7 A;  2INQ A;  3NZ9 X;  4PST A;  1RA1 A;  1KMV A;  4QLG A;  3QLS A;  3QLW A;  4IXE D;  1AI9 A;  3F8Z A;  2XW7 A;  3EEJ A;  2W9G A;  3FS6 A;  3JTW A;  3F91 A;  1PD9 A;  4LEK X;  1DHI A;  4Q0D A;  1RG7 A;  3D80 A;  1TDR A;  5E8Q A;  1J3J A;  3GHW A;  4KM2 A;  1RX5 A;  3SH2 A;  3I3R A;  3EIG A;  2AZN A;  3F0V X;  3NTZ A;  4QJZ D;  1RX1 A;  2GD9 A;  4PSS A;  3FQC A;  5HVB A;  3FRB X;  4EIL A;  3JWK A;  3DL5 A;  3EEM A;  4LAE X;  4M7V A;  1DRA A;  1DRH A;  5HI6 A;  4X5H A;  1CZ3 A;  1DLR A;  3INV A;  1MVT A;  1HFR A;  2QK8 A;  4QHV A;  2G6V A;  1DR6 A;  3NZD A;  4PDJ A;  1RB2 A;  5FDA A;  3QL0 A;  4X5I A;  1JOL A;  1RB3 A;  3SQY X;  3DGA A;  3ROA A;  1DRB A;  4Q67 A;  4ELE A;  1VDR A;  1RX8 A;  1RX3 A;  4I13 A;  1DDR A;  1DR4 A;  4ECK A;  4RGC A;  3JWM A;  1SEJ A;  3SRU X;  4KM0 A;  5DFR A;  1DRF A;  3FL9 A;  1DHJ A;  2BL9 A;  4G3M A;  2ANO A;  3NZB X;  4KJL A;  5HQZ A;  4ELG A;  3QYO A;  5HPB A;  4KJJ A;  5JG0 X;  3QLX A;  2H2Q A;  4HOE A;  4M7U A;  1ZDR A;  3NXY A;  1DR2 A;  4KD7 A;  1DDS A;  3DRC A;  3NXR A;  3JW5 A;  4CD2 A;  4ELF A;  4M2X A;  1DHF A;  4KYA A;  3Q1H A;  4EIG A;  1MVS A;  4OR7 A;  3CL9 A;  2W9T A;  4H96 A;  4IXG X;  2D5N A;  4Q6A A;  1BOZ A;  3SA2 A;  3QG2 A;  4H95 A;  4M6K A;  8DFR A;  4I1N A;  4DP3 A;  1S3W A;  1DYR A;  1E26 A;  1RH3 A;  4XT5 A;  4HOF A;  4DPD A;  1RA3 A;  3NXV A;  3F0B X;  3FY9 X;  3DAT A;  3EEL A;  1DAJ A;  1JOM A;  2BLC A;  3NZA X;  3QYL A;  3EX8 A;  2OBC A;  5HUI A;  3ZPC A;  3DG8 A;  3FYV X;  5U27 A;  4ELH A;  1IA1 A;  2W9H A;  3SA1 A;  1AO8 A;  3FQO A;  3S9U A;  2ITH A;  3JWC A;  3DAU A;  3HBB A;  1RA9 A;  4KFJ A;  3ZPG A;  4FGG A;  3FRF X;  3FQZ A;  3JWF A;  5CC9 A;  1DYH A;  3SAI A;  2OIP A;  3IRN A;  2W3M A;  3I8A X;  3NXX A;  5HVE A;  4DFR A;  3UM8 A;  2O7P A;  3E0B A;  3M09 A;  2C2T A;  1J3I A;  2CD2 A;  2BLA A;  4XEC X;  3FRD X;  3K74 A;  1HFQ A;  4XT7 A;  1KMS A;  3FRA X;  4KY8 A;  3NXT A;  3QGT A;  3F0S X;  3KJS A;  3CSE A;  1YHO A;  3QLY A;  4PSY A;  3JVX A;  3TQB A;  1RA2 A;  1QZF A;  4KBN A;  4H97 A;  1JUV A;  4M6L A;  2LF1 A;  4KL9 A;  3FY8 X;  4QJC A;  1M78 A;  3RG9 A;  3LG4 A;  4H98 A;  1DR1 A;  3QFX A;  3TQ8 A;  3SRR X;  2FZJ A;  1HFP A;  3SRS X;  5EAJ A;  4X5G A;  3S3V A;  4KY4 A;  4HA9 A;  4OSG A;  5ECC A;  3OCH A;  1RC4 A;  4Q0E A;  1BZF A;  2JYB A;  3KGY A;  3QLR A;  1RF7 A;  3NRR A;  1CD2 A;  4EIZ A;  1U72 A;  2P4G A;  5JA3 A;  4FHB A;  4XT6 A;  2FZI A;  3SGY A;  1RE7 A;  2HXV A;  3GI2 A;  3TD8 A;  3IRO A;  3SRW X;  4QI9 A;  1KLK A;  3EEK A;  5CCC A;  1RD7 A;  3D84 X;  2L28 A;  3DFR A;  2HQP A;  3NU0 A;  3OAF A;  2D0K A;  3K47 A;  3NXO A;  4M6J A;  1M79 A;  4PTJ A;  3L3R A;  1S3V A;  3K45 A;  4XRB A;  2W3A A;  3QLZ A;  3FQF A;  2ZZA A;  6DFR A;  2DRC A;  3HJ3 A;  1LY3 A;  4NX7 A;  4KEB A;  1DG7 A;  1DR7 A;  1IA4 A;  2CIG A;  5HSU A;  3JSU A;  1IA3 A;  4DDR A;  1U70 A;  4XT8 A;  3NZ6 X;  3F0Q X;  1DYJ A;  3KY8 A;  3UM6 A;  5HQY A;  5HT5 A;  1PDB A;  3FQV A;  4ELB A;  3UM5 A;  3F0U X;  4LAH X;  4TU5 X;  1PD8 A;  3TQA A;  3IX9 A;  4P66 A;  3F8Y A;  3KFY A;  3SR5 X;  4KJK A;  3RO9 A;  5HSR A;  4LAG X;  7DFR A;  3CLB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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