2FZIA

New insights into dhfr interactions: analysis of pneumocystis carinii and mouse dhfr complexes with nadph and two highly potent trimethoprim derivatives
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
206
structure length
206
Chain Sequence
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Pneumocystis carinii
molecule keywords Dihydrofolate reductase
total genus 58
structure length 206
sequence length 206
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2006-02-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 2fziA00
2C2TA 1DYJA 1AI9A 5CCCA 2FZHA 2W3AA 3CSEA 4M2XA 1DG7A 3NXVA 3JW5A 3RG9A 1RE7A 1DR6A 4H97A 3DGAA 3HJ3A 3NTZA 5U27A 4Q67A 4PSYA 2OBCA 3NU0A 4HA7A 4H95A 1DR7A 2HM9A 3FREX 3SAIA 4X5JA 4KJJA 3QLZA 4XT8A 1AOEA 2D0KA 2CD2A 1PD8A 3K2HA 3NXOA 4IXGX 3IX9A 4OR7A 4HA9A 4KAKA 3FY8X 3NXRA 4NX7A 3GYFA 2KGKA 3KGYA 4KNEA 3K47A 2C2SA 1DRHA 2W9HA 2W3BA 3S9UA 4CD2A 4PSSA 2W9SA 3FRDX 4LEKX 3FQCA 4ELBA 3FRFX 4FGGA 4KM2A 5JG0X 1DF7A 3FQVA 4NX6A 5HF2X 1DR3A 3NZ6X 5DFRA 3F0QX 3FL8A 5HSUA 3FYWX 1OHKA 4XRBA 3TQBA 5HF0X 4FHBA 3NRRA 4LAGX 5E8QA 2G6VA 3EIGA 2ITHA 1BOZA 4FGHA 6DFRA 4ECKA 3SQYX 4XE6X 1TDRA 1RH3A 3UM5A 3SA1A 1RX8A 3RO9A 4M7UA 1J3JA 3ZPGA 1RA9A 4I13A 1DDRA 1KMVA 3SH2A 1PDBA 3FY9X 4KEBA 1U72A 3QG2A 1RA3A 5HT5A 1DR2A 4Q6AA 4KL9A 1RC4A 3FQOA 1RX5A 4DFRA 3M08A 4RGCA 1U71A 3SRWX 3Q1HA 3N0HA 2W9GA 4KM0A 1D1GA 5HI6A 1DR1A 3NZ9X 3S7AA 4X5GA 1DYHA 2XW7A 4QHVA 4OSGA 1JOLA 2BLAA 3DL5A 1S3UA 3KY8A 4ELEA 2ANOA 4IXFX 1SEJA 4G95A 3HBBA 3NXTA 4G8ZX 3F0SX 2OIPA 4PSTA 3F0XX 1RX7A 3QLRA 3F0UX 3R33A 3EELA 4I1NA 2W3VA 3FRBX 2ANQA 5HVBA 2H2QA 1DREA 1MVSA 3S3VA 4PTJA 3TQ9A 2DHFA 1S3WA 1DYIA 4PTHA 3JVXA 3K74A 4P66A 1RX1A 1AO8A 4G3MA 3UM6A 3DRCA 4DPHA 5HT4A 3DAUA 3ZPCA 4QLGA 1LY3A 3D80A 1VJ3A 4M6KA 7DFRA 3SRSX 4XT4A 3L3RA 1J3IA 1DHJA 4QLFA 3CD2A 1HFRA 1OHJA 2DRCA 3FS6A 4Q0DA 1DLRA 1LUDA 3CL9A 1U70A 3IRNA 3SRRX 3QL0A 1RX9A 3D84X 3EEJA 2W3WA 3F0BX 5HQYA 1M7AA 4EILA 4P3QA 2D5NA 1RF7A 1MVTA 3NZCX 4KYAA 3SGYA 3IA4A 1RX2A 3NXXA 4KFJA 3DFRA 3QFXA 3SRUX 4P68A 3SRQX 1DISA 2L28A 4KJKA 1CD2A 3FQFA 2BLCA 4X5FA 3EEMA 1RX3A 1DG5A 1JOMA 1DR5A 4HOGA 2ZZAA 4EIGA 1DDSA 4HOEA 2B3ZA 2O7PA 4XT6A 4KY8A 3FL9A 3NXYA 1M79A 3LG4A 1CZ3A 1RA8A 1DIUA 4XT5A 3GHCA 3KJRA 2GD9A 3FQ0A 4KLXA 5HUIA 1IA2A 3JWFA 1RB2A 4H98A 3JWMA 2W9TA 4H96A 3NZAX 4IXED 3ROAA 4HOFA 4Q0EA 5DXVA 3JWKA 4X5IA 1DAJA 3F91A 5CC9A 5HPBA 1DHFA 3KFYA 3GHVA 2P4GA 3FQZA 1LY4A 4KBNA 4DDRA 2AZNA 4XT7A 3NZBX 1DRBA 3QLXA 4QJCA 5ECXA 3SA2A 1RB3A 4XECX 1HFPA 3QL3A 4QI9A 4DPDA 3GHWA 4KD7A 1IA3A 3F0VX 2W3MA 2JYBA 3QLYA 3GI2A 3F8YA 1YHOA 3QGTA 3IROA 3QLSA 1JUVA 1J3KA 1DRAA 5FDAA 4ELGA 1ZDRA 1BZFA 3F8ZA 2INQA 4X5HA 3IA5A 3QYOA 2HQPA 5HQZA 3DL6A 3QLWA 1M78A 3FYVX 3JW3A 8DFRA 5JA3A 2LF1A 4QLEA 3VCOA 1DHIA 3TQ8A 3CLBA 3IRMA 1RX4A 5U26A 1QZFA 3OCHA 1PD9A 3K45A 3EX8A 4P3RA 1RX6A 4TU5X 3I3RA 5HSRA 3FRAX 1RA1A 4DP3A 1E26A 1DYRA 2FZIA 3DATA 3E0BA 3NZDA 3DG8A 4KJLA 2FZJA 4EIZA 3JTWA 3TQAA 1VDRA 1IA4A 3JSUA 4GH8A 1DR4A 3OAFA 1DRFA 2CIGA 3INVA 3M09A 3QYLA 1IA1A 2QK8A 1KLKA 4ELFA 4EJ1A 3EEKA 4KY4A 1RA2A 2BLBA 1DLSA 2HXVA 3SR5X 3UM8A 3JWCA 4M7VA 3KJSA 1KMSA 3TD8A 1RG7A 1DG8A 4M6JA 4QJZD 5HVEA 1S3YA 5EAJA 1S3VA 5ECCA 4ELHA 4LAEX 4PDJA 4M6LA 1HFQA 2BL9A 4LAHX 1RD7A 3I8AX
chains in the Genus database with same CATH superfamily
2C2TA 1DYJA 1AI9A 5CCCA 2FZHA 2W3AA 3CSEA 4M2XA 1DG7A 3NXVA 3JW5A 3RG9A 1RE7A 1DR6A 4H97A 3DGAA 3HJ3A 3NTZA 5U27A 4Q67A 4PSYA 2OBCA 3NU0A 4HA7A 4H95A 1DR7A 2HM9A 3FREX 3SAIA 4X5JA 4KJJA 3QLZA 4XT8A 1AOEA 2D0KA 2CD2A 1PD8A 3K2HA 3NXOA 4IXGX 3IX9A 4OR7A 4HA9A 4KAKA 3FY8X 3NXRA 4NX7A 3GYFA 2KGKA 3KGYA 4KNEA 3K47A 2C2SA 1DRHA 2W9HA 2W3BA 3S9UA 4CD2A 4PSSA 2W9SA 3FRDX 4LEKX 3FQCA 4ELBA 3FRFX 4FGGA 4KM2A 5JG0X 1DF7A 3FQVA 4NX6A 5HF2X 1DR3A 3NZ6X 5DFRA 3F0QX 3FL8A 5HSUA 3FYWX 1OHKA 4XRBA 3TQBA 5HF0X 4FHBA 3NRRA 4LAGX 5E8QA 2G6VA 3EIGA 2ITHA 1BOZA 4FGHA 6DFRA 4ECKA 3SQYX 4XE6X 1TDRA 1RH3A 3UM5A 3SA1A 1RX8A 3RO9A 4M7UA 1J3JA 3ZPGA 1RA9A 4I13A 1DDRA 1KMVA 3SH2A 1PDBA 3FY9X 4KEBA 1U72A 3QG2A 1RA3A 5HT5A 1DR2A 4Q6AA 4KL9A 1RC4A 3FQOA 1RX5A 4DFRA 3M08A 4RGCA 1U71A 3SRWX 3Q1HA 3N0HA 2W9GA 4KM0A 1D1GA 5HI6A 1DR1A 3NZ9X 3S7AA 4X5GA 1DYHA 2XW7A 4QHVA 4OSGA 1JOLA 2BLAA 3DL5A 1S3UA 3KY8A 4ELEA 2ANOA 4IXFX 1SEJA 4G95A 3HBBA 3NXTA 4G8ZX 3F0SX 2OIPA 4PSTA 3F0XX 1RX7A 3QLRA 3F0UX 3R33A 3EELA 4I1NA 2W3VA 3FRBX 2ANQA 5HVBA 2H2QA 1DREA 1MVSA 3S3VA 4PTJA 3TQ9A 2DHFA 1S3WA 1DYIA 4PTHA 3JVXA 3K74A 4P66A 1RX1A 1AO8A 4G3MA 3UM6A 3DRCA 4DPHA 5HT4A 3DAUA 3ZPCA 4QLGA 1LY3A 3D80A 1VJ3A 4M6KA 7DFRA 3SRSX 4XT4A 3L3RA 1J3IA 1DHJA 4QLFA 3CD2A 1HFRA 1OHJA 2DRCA 3FS6A 4Q0DA 1DLRA 1LUDA 3CL9A 1U70A 3IRNA 3SRRX 3QL0A 1RX9A 3D84X 3EEJA 2W3WA 3F0BX 5HQYA 1M7AA 4EILA 4P3QA 2D5NA 1RF7A 1MVTA 3NZCX 4KYAA 3SGYA 3IA4A 1RX2A 3NXXA 4KFJA 3DFRA 3QFXA 3SRUX 4P68A 3SRQX 1DISA 2L28A 4KJKA 1CD2A 3FQFA 2BLCA 4X5FA 3EEMA 1RX3A 1DG5A 1JOMA 1DR5A 4HOGA 2ZZAA 4EIGA 1DDSA 4HOEA 2B3ZA 2O7PA 4XT6A 4KY8A 3FL9A 3NXYA 1M79A 3LG4A 1CZ3A 1RA8A 1DIUA 4XT5A 3GHCA 3KJRA 2GD9A 3FQ0A 4KLXA 5HUIA 1IA2A 3JWFA 1RB2A 4H98A 3JWMA 2W9TA 4H96A 3NZAX 4IXED 3ROAA 4HOFA 4Q0EA 5DXVA 3JWKA 4X5IA 1DAJA 3F91A 5CC9A 5HPBA 1DHFA 3KFYA 3GHVA 2P4GA 3FQZA 1LY4A 4KBNA 4DDRA 2AZNA 4XT7A 3NZBX 1DRBA 3QLXA 4QJCA 5ECXA 3SA2A 1RB3A 4XECX 1HFPA 3QL3A 4QI9A 4DPDA 3GHWA 4KD7A 1IA3A 3F0VX 2W3MA 2JYBA 3QLYA 3GI2A 3F8YA 1YHOA 3QGTA 3IROA 3QLSA 1JUVA 1J3KA 1DRAA 5FDAA 4ELGA 1ZDRA 1BZFA 3F8ZA 2INQA 4X5HA 3IA5A 3QYOA 2HQPA 5HQZA 3DL6A 3QLWA 1M78A 3FYVX 3JW3A 8DFRA 5JA3A 2LF1A 4QLEA 3VCOA 1DHIA 3TQ8A 3CLBA 3IRMA 1RX4A 5U26A 1QZFA 3OCHA 1PD9A 3K45A 3EX8A 4P3RA 1RX6A 4TU5X 3I3RA 5HSRA 3FRAX 1RA1A 4DP3A 1E26A 1DYRA 2FZIA 3DATA 3E0BA 3NZDA 3DG8A 4KJLA 2FZJA 4EIZA 3JTWA 3TQAA 1VDRA 1IA4A 3JSUA 4GH8A 1DR4A 3OAFA 1DRFA 2CIGA 3INVA 3M09A 3QYLA 1IA1A 2QK8A 1KLKA 4ELFA 4EJ1A 3EEKA 4KY4A 1RA2A 2BLBA 1DLSA 2HXVA 3SR5X 3UM8A 3JWCA 4M7VA 3KJSA 1KMSA 3TD8A 1RG7A 1DG8A 4M6JA 4QJZD 5HVEA 1S3YA 5EAJA 1S3VA 5ECCA 4ELHA 4LAEX 4PDJA 4M6LA 1HFQA 2BL9A 4LAHX 1RD7A 3I8AX
chains in the Genus database with same CATH topology
2C2TA 1DYJA 1AI9A 5CCCA 2FZHA 2W3AA 3CSEA 4M2XA 1DG7A 3NXVA 3JW5A 3RG9A 1RE7A 1DR6A 4H97A 3DGAA 3HJ3A 3NTZA 5U27A 4Q67A 4PSYA 2OBCA 3NU0A 4HA7A 4H95A 1DR7A 2HM9A 3FREX 3SAIA 4X5JA 4KJJA 3QLZA 4XT8A 1AOEA 2D0KA 2CD2A 1PD8A 3K2HA 3NXOA 4IXGX 3IX9A 4OR7A 4HA9A 4KAKA 3FY8X 3NXRA 4NX7A 3GYFA 2KGKA 3KGYA 4KNEA 3K47A 2C2SA 1DRHA 2W9HA 2W3BA 3S9UA 4CD2A 4PSSA 2W9SA 3FRDX 4LEKX 3FQCA 4ELBA 3FRFX 4FGGA 4KM2A 5JG0X 1DF7A 3FQVA 4NX6A 5HF2X 1DR3A 3NZ6X 5DFRA 3F0QX 3FL8A 5HSUA 3FYWX 1OHKA 4XRBA 3TQBA 5HF0X 4FHBA 3NRRA 4LAGX 5E8QA 2G6VA 3EIGA 2ITHA 1BOZA 4FGHA 6DFRA 4ECKA 3SQYX 4XE6X 1TDRA 1RH3A 3UM5A 3SA1A 1RX8A 3RO9A 4M7UA 1J3JA 3ZPGA 1RA9A 4I13A 1DDRA 1KMVA 3SH2A 1PDBA 3FY9X 4KEBA 1U72A 3QG2A 1RA3A 5HT5A 1DR2A 4Q6AA 4KL9A 1RC4A 3FQOA 1RX5A 4DFRA 3M08A 4RGCA 1U71A 3SRWX 3Q1HA 3N0HA 2W9GA 4KM0A 1D1GA 5HI6A 1DR1A 3NZ9X 3S7AA 4X5GA 1DYHA 2XW7A 4QHVA 4OSGA 1JOLA 2BLAA 3DL5A 1S3UA 3KY8A 4ELEA 2ANOA 4IXFX 1SEJA 4G95A 3HBBA 3NXTA 4G8ZX 3F0SX 2OIPA 4PSTA 3F0XX 1RX7A 3QLRA 3F0UX 3R33A 3EELA 4I1NA 2W3VA 3FRBX 2ANQA 5HVBA 2H2QA 1DREA 1MVSA 3S3VA 4PTJA 3TQ9A 2DHFA 1S3WA 1DYIA 4PTHA 3JVXA 3K74A 4P66A 1RX1A 1AO8A 4G3MA 3UM6A 3DRCA 4DPHA 5HT4A 3DAUA 3ZPCA 4QLGA 1LY3A 3D80A 1VJ3A 4M6KA 7DFRA 3SRSX 4XT4A 3L3RA 1J3IA 1DHJA 4QLFA 3CD2A 1HFRA 1OHJA 2DRCA 3FS6A 4Q0DA 1DLRA 1LUDA 3CL9A 1U70A 3IRNA 3SRRX 3QL0A 1RX9A 3D84X 3EEJA 2W3WA 3F0BX 5HQYA 1M7AA 4EILA 4P3QA 2D5NA 1RF7A 1MVTA 3NZCX 4KYAA 3SGYA 3IA4A 1RX2A 3NXXA 4KFJA 3DFRA 3QFXA 3SRUX 4P68A 3SRQX 1DISA 2L28A 4KJKA 1CD2A 3FQFA 2BLCA 4X5FA 3EEMA 1RX3A 1DG5A 1JOMA 1DR5A 4HOGA 2ZZAA 4EIGA 1DDSA 4HOEA 2B3ZA 2O7PA 4XT6A 4KY8A 3FL9A 3NXYA 1M79A 3LG4A 1CZ3A 1RA8A 1DIUA 4XT5A 3GHCA 3KJRA 2GD9A 3FQ0A 4KLXA 5HUIA 1IA2A 3JWFA 1RB2A 4H98A 3JWMA 2W9TA 4H96A 3NZAX 4IXED 3ROAA 4HOFA 4Q0EA 5DXVA 3JWKA 4X5IA 1DAJA 3F91A 5CC9A 5HPBA 1DHFA 3KFYA 3GHVA 2P4GA 3FQZA 1LY4A 4KBNA 4DDRA 2AZNA 4XT7A 3NZBX 1DRBA 3QLXA 4QJCA 5ECXA 3SA2A 1RB3A 4XECX 1HFPA 3QL3A 4QI9A 4DPDA 3GHWA 4KD7A 1IA3A 3F0VX 2W3MA 2JYBA 3QLYA 3GI2A 3F8YA 1YHOA 3QGTA 3IROA 3QLSA 1JUVA 1J3KA 1DRAA 5FDAA 4ELGA 1ZDRA 1BZFA 3F8ZA 2INQA 4X5HA 3IA5A 3QYOA 2HQPA 5HQZA 3DL6A 3QLWA 1M78A 3FYVX 3JW3A 8DFRA 5JA3A 2LF1A 4QLEA 3VCOA 1DHIA 3TQ8A 3CLBA 3IRMA 1RX4A 5U26A 1QZFA 3OCHA 1PD9A 3K45A 3EX8A 4P3RA 1RX6A 4TU5X 3I3RA 5HSRA 3FRAX 1RA1A 4DP3A 1E26A 1DYRA 2FZIA 3DATA 3E0BA 3NZDA 3DG8A 4KJLA 2FZJA 4EIZA 3JTWA 3TQAA 1VDRA 1IA4A 3JSUA 4GH8A 1DR4A 3OAFA 1DRFA 2CIGA 3INVA 3M09A 3QYLA 1IA1A 2QK8A 1KLKA 4ELFA 4EJ1A 3EEKA 4KY4A 1RA2A 2BLBA 1DLSA 2HXVA 3SR5X 3UM8A 3JWCA 4M7VA 3KJSA 1KMSA 3TD8A 1RG7A 1DG8A 4M6JA 4QJZD 5HVEA 1S3YA 5EAJA 1S3VA 5ECCA 4ELHA 4LAEX 4PDJA 4M6LA 1HFQA 2BL9A 4LAHX 1RD7A 3I8AX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C2T A;  1DYJ A;  1AI9 A;  5CCC A;  2FZH A;  2W3A A;  3CSE A;  4M2X A;  1DG7 A;  3NXV A;  3JW5 A;  3RG9 A;  1RE7 A;  1DR6 A;  4H97 A;  3DGA A;  3HJ3 A;  3NTZ A;  5U27 A;  4Q67 A;  4PSY A;  2OBC A;  3NU0 A;  4HA7 A;  4H95 A;  1DR7 A;  2HM9 A;  3FRE X;  3SAI A;  4X5J A;  4KJJ A;  3QLZ A;  4XT8 A;  1AOE A;  2D0K A;  2CD2 A;  1PD8 A;  3K2H A;  3NXO A;  4IXG X;  3IX9 A;  4OR7 A;  4HA9 A;  4KAK A;  3FY8 X;  3NXR A;  4NX7 A;  3GYF A;  2KGK A;  3KGY A;  4KNE A;  3K47 A;  2C2S A;  1DRH A;  2W9H A;  2W3B A;  3S9U A;  4CD2 A;  4PSS A;  2W9S A;  3FRD X;  4LEK X;  3FQC A;  4ELB A;  3FRF X;  4FGG A;  4KM2 A;  5JG0 X;  1DF7 A;  3FQV A;  4NX6 A;  5HF2 X;  1DR3 A;  3NZ6 X;  5DFR A;  3F0Q X;  3FL8 A;  5HSU A;  3FYW X;  1OHK A;  4XRB A;  3TQB A;  5HF0 X;  4FHB A;  3NRR A;  4LAG X;  5E8Q A;  2G6V A;  3EIG A;  2ITH A;  1BOZ A;  4FGH A;  6DFR A;  4ECK A;  3SQY X;  4XE6 X;  1TDR A;  1RH3 A;  3UM5 A;  3SA1 A;  1RX8 A;  3RO9 A;  4M7U A;  1J3J A;  3ZPG A;  1RA9 A;  4I13 A;  1DDR A;  1KMV A;  3SH2 A;  1PDB A;  3FY9 X;  4KEB A;  1U72 A;  3QG2 A;  1RA3 A;  5HT5 A;  1DR2 A;  4Q6A A;  4KL9 A;  1RC4 A;  3FQO A;  1RX5 A;  4DFR A;  3M08 A;  4RGC A;  1U71 A;  3SRW X;  3Q1H A;  3N0H A;  2W9G A;  4KM0 A;  1D1G A;  5HI6 A;  1DR1 A;  3NZ9 X;  3S7A A;  4X5G A;  1DYH A;  2XW7 A;  4QHV A;  4OSG A;  1JOL A;  2BLA A;  3DL5 A;  1S3U A;  3KY8 A;  4ELE A;  2ANO A;  4IXF X;  1SEJ A;  4G95 A;  3HBB A;  3NXT A;  4G8Z X;  3F0S X;  2OIP A;  4PST A;  3F0X X;  1RX7 A;  3QLR A;  3F0U X;  3R33 A;  3EEL A;  4I1N A;  2W3V A;  3FRB X;  2ANQ A;  5HVB A;  2H2Q A;  1DRE A;  1MVS A;  3S3V A;  4PTJ A;  3TQ9 A;  2DHF A;  1S3W A;  1DYI A;  4PTH A;  3JVX A;  3K74 A;  4P66 A;  1RX1 A;  1AO8 A;  4G3M A;  3UM6 A;  3DRC A;  4DPH A;  5HT4 A;  3DAU A;  3ZPC A;  4QLG A;  1LY3 A;  3D80 A;  1VJ3 A;  4M6K A;  7DFR A;  3SRS X;  4XT4 A;  3L3R A;  1J3I A;  1DHJ A;  4QLF A;  3CD2 A;  1HFR A;  1OHJ A;  2DRC A;  3FS6 A;  4Q0D A;  1DLR A;  1LUD A;  3CL9 A;  1U70 A;  3IRN A;  3SRR X;  3QL0 A;  1RX9 A;  3D84 X;  3EEJ A;  2W3W A;  3F0B X;  5HQY A;  1M7A A;  4EIL A;  4P3Q A;  2D5N A;  1RF7 A;  1MVT A;  3NZC X;  4KYA A;  3SGY A;  3IA4 A;  1RX2 A;  3NXX A;  4KFJ A;  3DFR A;  3QFX A;  3SRU X;  4P68 A;  3SRQ X;  1DIS A;  2L28 A;  4KJK A;  1CD2 A;  3FQF A;  2BLC A;  4X5F A;  3EEM A;  1RX3 A;  1DG5 A;  1JOM A;  1DR5 A;  4HOG A;  2ZZA A;  4EIG A;  1DDS A;  4HOE A;  2B3Z A;  2O7P A;  4XT6 A;  4KY8 A;  3FL9 A;  3NXY A;  1M79 A;  3LG4 A;  1CZ3 A;  1RA8 A;  1DIU A;  4XT5 A;  3GHC A;  3KJR A;  2GD9 A;  3FQ0 A;  4KLX A;  5HUI A;  1IA2 A;  3JWF A;  1RB2 A;  4H98 A;  3JWM A;  2W9T A;  4H96 A;  3NZA X;  4IXE D;  3ROA A;  4HOF A;  4Q0E A;  5DXV A;  3JWK A;  4X5I A;  1DAJ A;  3F91 A;  5CC9 A;  5HPB A;  1DHF A;  3KFY A;  3GHV A;  2P4G A;  3FQZ A;  1LY4 A;  4KBN A;  4DDR A;  2AZN A;  4XT7 A;  3NZB X;  1DRB A;  3QLX A;  4QJC A;  5ECX A;  3SA2 A;  1RB3 A;  4XEC X;  1HFP A;  3QL3 A;  4QI9 A;  4DPD A;  3GHW A;  4KD7 A;  1IA3 A;  3F0V X;  2W3M A;  2JYB A;  3QLY A;  3GI2 A;  3F8Y A;  1YHO A;  3QGT A;  3IRO A;  3QLS A;  1JUV A;  1J3K A;  1DRA A;  5FDA A;  4ELG A;  1ZDR A;  1BZF A;  3F8Z A;  2INQ A;  4X5H A;  3IA5 A;  3QYO A;  2HQP A;  5HQZ A;  3DL6 A;  3QLW A;  1M78 A;  3FYV X;  3JW3 A;  8DFR A;  5JA3 A;  2LF1 A;  4QLE A;  3VCO A;  1DHI A;  3TQ8 A;  3CLB A;  3IRM A;  1RX4 A;  5U26 A;  1QZF A;  3OCH A;  1PD9 A;  3K45 A;  3EX8 A;  4P3R A;  1RX6 A;  4TU5 X;  3I3R A;  5HSR A;  3FRA X;  1RA1 A;  4DP3 A;  1E26 A;  1DYR A;  2FZI A;  3DAT A;  3E0B A;  3NZD A;  3DG8 A;  4KJL A;  2FZJ A;  4EIZ A;  3JTW A;  3TQA A;  1VDR A;  1IA4 A;  3JSU A;  4GH8 A;  1DR4 A;  3OAF A;  1DRF A;  2CIG A;  3INV A;  3M09 A;  3QYL A;  1IA1 A;  2QK8 A;  1KLK A;  4ELF A;  4EJ1 A;  3EEK A;  4KY4 A;  1RA2 A;  2BLB A;  1DLS A;  2HXV A;  3SR5 X;  3UM8 A;  3JWC A;  4M7V A;  3KJS A;  1KMS A;  3TD8 A;  1RG7 A;  1DG8 A;  4M6J A;  4QJZ D;  5HVE A;  1S3Y A;  5EAJ A;  1S3V A;  5ECC A;  4ELH A;  4LAE X;  4PDJ A;  4M6L A;  1HFQ A;  2BL9 A;  4LAH X;  1RD7 A;  3I8A X; 
#chains in the Genus database with same CATH topology
 2C2T A;  1DYJ A;  1AI9 A;  5CCC A;  2FZH A;  2W3A A;  3CSE A;  4M2X A;  1DG7 A;  3NXV A;  3JW5 A;  3RG9 A;  1RE7 A;  1DR6 A;  4H97 A;  3DGA A;  3HJ3 A;  3NTZ A;  5U27 A;  4Q67 A;  4PSY A;  2OBC A;  3NU0 A;  4HA7 A;  4H95 A;  1DR7 A;  2HM9 A;  3FRE X;  3SAI A;  4X5J A;  4KJJ A;  3QLZ A;  4XT8 A;  1AOE A;  2D0K A;  2CD2 A;  1PD8 A;  3K2H A;  3NXO A;  4IXG X;  3IX9 A;  4OR7 A;  4HA9 A;  4KAK A;  3FY8 X;  3NXR A;  4NX7 A;  3GYF A;  2KGK A;  3KGY A;  4KNE A;  3K47 A;  2C2S A;  1DRH A;  2W9H A;  2W3B A;  3S9U A;  4CD2 A;  4PSS A;  2W9S A;  3FRD X;  4LEK X;  3FQC A;  4ELB A;  3FRF X;  4FGG A;  4KM2 A;  5JG0 X;  1DF7 A;  3FQV A;  4NX6 A;  5HF2 X;  1DR3 A;  3NZ6 X;  5DFR A;  3F0Q X;  3FL8 A;  5HSU A;  3FYW X;  1OHK A;  4XRB A;  3TQB A;  5HF0 X;  4FHB A;  3NRR A;  4LAG X;  5E8Q A;  2G6V A;  3EIG A;  2ITH A;  1BOZ A;  4FGH A;  6DFR A;  4ECK A;  3SQY X;  4XE6 X;  1TDR A;  1RH3 A;  3UM5 A;  3SA1 A;  1RX8 A;  3RO9 A;  4M7U A;  1J3J A;  3ZPG A;  1RA9 A;  4I13 A;  1DDR A;  1KMV A;  3SH2 A;  1PDB A;  3FY9 X;  4KEB A;  1U72 A;  3QG2 A;  1RA3 A;  5HT5 A;  1DR2 A;  4Q6A A;  4KL9 A;  1RC4 A;  3FQO A;  1RX5 A;  4DFR A;  3M08 A;  4RGC A;  1U71 A;  3SRW X;  3Q1H A;  3N0H A;  2W9G A;  4KM0 A;  1D1G A;  5HI6 A;  1DR1 A;  3NZ9 X;  3S7A A;  4X5G A;  1DYH A;  2XW7 A;  4QHV A;  4OSG A;  1JOL A;  2BLA A;  3DL5 A;  1S3U A;  3KY8 A;  4ELE A;  2ANO A;  4IXF X;  1SEJ A;  4G95 A;  3HBB A;  3NXT A;  4G8Z X;  3F0S X;  2OIP A;  4PST A;  3F0X X;  1RX7 A;  3QLR A;  3F0U X;  3R33 A;  3EEL A;  4I1N A;  2W3V A;  3FRB X;  2ANQ A;  5HVB A;  2H2Q A;  1DRE A;  1MVS A;  3S3V A;  4PTJ A;  3TQ9 A;  2DHF A;  1S3W A;  1DYI A;  4PTH A;  3JVX A;  3K74 A;  4P66 A;  1RX1 A;  1AO8 A;  4G3M A;  3UM6 A;  3DRC A;  4DPH A;  5HT4 A;  3DAU A;  3ZPC A;  4QLG A;  1LY3 A;  3D80 A;  1VJ3 A;  4M6K A;  7DFR A;  3SRS X;  4XT4 A;  3L3R A;  1J3I A;  1DHJ A;  4QLF A;  3CD2 A;  1HFR A;  1OHJ A;  2DRC A;  3FS6 A;  4Q0D A;  1DLR A;  1LUD A;  3CL9 A;  1U70 A;  3IRN A;  3SRR X;  3QL0 A;  1RX9 A;  3D84 X;  3EEJ A;  2W3W A;  3F0B X;  5HQY A;  1M7A A;  4EIL A;  4P3Q A;  2D5N A;  1RF7 A;  1MVT A;  3NZC X;  4KYA A;  3SGY A;  3IA4 A;  1RX2 A;  3NXX A;  4KFJ A;  3DFR A;  3QFX A;  3SRU X;  4P68 A;  3SRQ X;  1DIS A;  2L28 A;  4KJK A;  1CD2 A;  3FQF A;  2BLC A;  4X5F A;  3EEM A;  1RX3 A;  1DG5 A;  1JOM A;  1DR5 A;  4HOG A;  2ZZA A;  4EIG A;  1DDS A;  4HOE A;  2B3Z A;  2O7P A;  4XT6 A;  4KY8 A;  3FL9 A;  3NXY A;  1M79 A;  3LG4 A;  1CZ3 A;  1RA8 A;  1DIU A;  4XT5 A;  3GHC A;  3KJR A;  2GD9 A;  3FQ0 A;  4KLX A;  5HUI A;  1IA2 A;  3JWF A;  1RB2 A;  4H98 A;  3JWM A;  2W9T A;  4H96 A;  3NZA X;  4IXE D;  3ROA A;  4HOF A;  4Q0E A;  5DXV A;  3JWK A;  4X5I A;  1DAJ A;  3F91 A;  5CC9 A;  5HPB A;  1DHF A;  3KFY A;  3GHV A;  2P4G A;  3FQZ A;  1LY4 A;  4KBN A;  4DDR A;  2AZN A;  4XT7 A;  3NZB X;  1DRB A;  3QLX A;  4QJC A;  5ECX A;  3SA2 A;  1RB3 A;  4XEC X;  1HFP A;  3QL3 A;  4QI9 A;  4DPD A;  3GHW A;  4KD7 A;  1IA3 A;  3F0V X;  2W3M A;  2JYB A;  3QLY A;  3GI2 A;  3F8Y A;  1YHO A;  3QGT A;  3IRO A;  3QLS A;  1JUV A;  1J3K A;  1DRA A;  5FDA A;  4ELG A;  1ZDR A;  1BZF A;  3F8Z A;  2INQ A;  4X5H A;  3IA5 A;  3QYO A;  2HQP A;  5HQZ A;  3DL6 A;  3QLW A;  1M78 A;  3FYV X;  3JW3 A;  8DFR A;  5JA3 A;  2LF1 A;  4QLE A;  3VCO A;  1DHI A;  3TQ8 A;  3CLB A;  3IRM A;  1RX4 A;  5U26 A;  1QZF A;  3OCH A;  1PD9 A;  3K45 A;  3EX8 A;  4P3R A;  1RX6 A;  4TU5 X;  3I3R A;  5HSR A;  3FRA X;  1RA1 A;  4DP3 A;  1E26 A;  1DYR A;  2FZI A;  3DAT A;  3E0B A;  3NZD A;  3DG8 A;  4KJL A;  2FZJ A;  4EIZ A;  3JTW A;  3TQA A;  1VDR A;  1IA4 A;  3JSU A;  4GH8 A;  1DR4 A;  3OAF A;  1DRF A;  2CIG A;  3INV A;  3M09 A;  3QYL A;  1IA1 A;  2QK8 A;  1KLK A;  4ELF A;  4EJ1 A;  3EEK A;  4KY4 A;  1RA2 A;  2BLB A;  1DLS A;  2HXV A;  3SR5 X;  3UM8 A;  3JWC A;  4M7V A;  3KJS A;  1KMS A;  3TD8 A;  1RG7 A;  1DG8 A;  4M6J A;  4QJZ D;  5HVE A;  1S3Y A;  5EAJ A;  1S3V A;  5ECC A;  4ELH A;  4LAE X;  4PDJ A;  4M6L A;  1HFQ A;  2BL9 A;  4LAH X;  1RD7 A;  3I8A X; 
#chains in the Genus database with same CATH homology
 2C2T A;  1DYJ A;  1AI9 A;  5CCC A;  2FZH A;  2W3A A;  3CSE A;  4M2X A;  1DG7 A;  3NXV A;  3JW5 A;  3RG9 A;  1RE7 A;  1DR6 A;  4H97 A;  3DGA A;  3HJ3 A;  3NTZ A;  5U27 A;  4Q67 A;  4PSY A;  2OBC A;  3NU0 A;  4HA7 A;  4H95 A;  1DR7 A;  2HM9 A;  3FRE X;  3SAI A;  4X5J A;  4KJJ A;  3QLZ A;  4XT8 A;  1AOE A;  2D0K A;  2CD2 A;  1PD8 A;  3K2H A;  3NXO A;  4IXG X;  3IX9 A;  4OR7 A;  4HA9 A;  4KAK A;  3FY8 X;  3NXR A;  4NX7 A;  3GYF A;  2KGK A;  3KGY A;  4KNE A;  3K47 A;  2C2S A;  1DRH A;  2W9H A;  2W3B A;  3S9U A;  4CD2 A;  4PSS A;  2W9S A;  3FRD X;  4LEK X;  3FQC A;  4ELB A;  3FRF X;  4FGG A;  4KM2 A;  5JG0 X;  1DF7 A;  3FQV A;  4NX6 A;  5HF2 X;  1DR3 A;  3NZ6 X;  5DFR A;  3F0Q X;  3FL8 A;  5HSU A;  3FYW X;  1OHK A;  4XRB A;  3TQB A;  5HF0 X;  4FHB A;  3NRR A;  4LAG X;  5E8Q A;  2G6V A;  3EIG A;  2ITH A;  1BOZ A;  4FGH A;  6DFR A;  4ECK A;  3SQY X;  4XE6 X;  1TDR A;  1RH3 A;  3UM5 A;  3SA1 A;  1RX8 A;  3RO9 A;  4M7U A;  1J3J A;  3ZPG A;  1RA9 A;  4I13 A;  1DDR A;  1KMV A;  3SH2 A;  1PDB A;  3FY9 X;  4KEB A;  1U72 A;  3QG2 A;  1RA3 A;  5HT5 A;  1DR2 A;  4Q6A A;  4KL9 A;  1RC4 A;  3FQO A;  1RX5 A;  4DFR A;  3M08 A;  4RGC A;  1U71 A;  3SRW X;  3Q1H A;  3N0H A;  2W9G A;  4KM0 A;  1D1G A;  5HI6 A;  1DR1 A;  3NZ9 X;  3S7A A;  4X5G A;  1DYH A;  2XW7 A;  4QHV A;  4OSG A;  1JOL A;  2BLA A;  3DL5 A;  1S3U A;  3KY8 A;  4ELE A;  2ANO A;  4IXF X;  1SEJ A;  4G95 A;  3HBB A;  3NXT A;  4G8Z X;  3F0S X;  2OIP A;  4PST A;  3F0X X;  1RX7 A;  3QLR A;  3F0U X;  3R33 A;  3EEL A;  4I1N A;  2W3V A;  3FRB X;  2ANQ A;  5HVB A;  2H2Q A;  1DRE A;  1MVS A;  3S3V A;  4PTJ A;  3TQ9 A;  2DHF A;  1S3W A;  1DYI A;  4PTH A;  3JVX A;  3K74 A;  4P66 A;  1RX1 A;  1AO8 A;  4G3M A;  3UM6 A;  3DRC A;  4DPH A;  5HT4 A;  3DAU A;  3ZPC A;  4QLG A;  1LY3 A;  3D80 A;  1VJ3 A;  4M6K A;  7DFR A;  3SRS X;  4XT4 A;  3L3R A;  1J3I A;  1DHJ A;  4QLF A;  3CD2 A;  1HFR A;  1OHJ A;  2DRC A;  3FS6 A;  4Q0D A;  1DLR A;  1LUD A;  3CL9 A;  1U70 A;  3IRN A;  3SRR X;  3QL0 A;  1RX9 A;  3D84 X;  3EEJ A;  2W3W A;  3F0B X;  5HQY A;  1M7A A;  4EIL A;  4P3Q A;  2D5N A;  1RF7 A;  1MVT A;  3NZC X;  4KYA A;  3SGY A;  3IA4 A;  1RX2 A;  3NXX A;  4KFJ A;  3DFR A;  3QFX A;  3SRU X;  4P68 A;  3SRQ X;  1DIS A;  2L28 A;  4KJK A;  1CD2 A;  3FQF A;  2BLC A;  4X5F A;  3EEM A;  1RX3 A;  1DG5 A;  1JOM A;  1DR5 A;  4HOG A;  2ZZA A;  4EIG A;  1DDS A;  4HOE A;  2B3Z A;  2O7P A;  4XT6 A;  4KY8 A;  3FL9 A;  3NXY A;  1M79 A;  3LG4 A;  1CZ3 A;  1RA8 A;  1DIU A;  4XT5 A;  3GHC A;  3KJR A;  2GD9 A;  3FQ0 A;  4KLX A;  5HUI A;  1IA2 A;  3JWF A;  1RB2 A;  4H98 A;  3JWM A;  2W9T A;  4H96 A;  3NZA X;  4IXE D;  3ROA A;  4HOF A;  4Q0E A;  5DXV A;  3JWK A;  4X5I A;  1DAJ A;  3F91 A;  5CC9 A;  5HPB A;  1DHF A;  3KFY A;  3GHV A;  2P4G A;  3FQZ A;  1LY4 A;  4KBN A;  4DDR A;  2AZN A;  4XT7 A;  3NZB X;  1DRB A;  3QLX A;  4QJC A;  5ECX A;  3SA2 A;  1RB3 A;  4XEC X;  1HFP A;  3QL3 A;  4QI9 A;  4DPD A;  3GHW A;  4KD7 A;  1IA3 A;  3F0V X;  2W3M A;  2JYB A;  3QLY A;  3GI2 A;  3F8Y A;  1YHO A;  3QGT A;  3IRO A;  3QLS A;  1JUV A;  1J3K A;  1DRA A;  5FDA A;  4ELG A;  1ZDR A;  1BZF A;  3F8Z A;  2INQ A;  4X5H A;  3IA5 A;  3QYO A;  2HQP A;  5HQZ A;  3DL6 A;  3QLW A;  1M78 A;  3FYV X;  3JW3 A;  8DFR A;  5JA3 A;  2LF1 A;  4QLE A;  3VCO A;  1DHI A;  3TQ8 A;  3CLB A;  3IRM A;  1RX4 A;  5U26 A;  1QZF A;  3OCH A;  1PD9 A;  3K45 A;  3EX8 A;  4P3R A;  1RX6 A;  4TU5 X;  3I3R A;  5HSR A;  3FRA X;  1RA1 A;  4DP3 A;  1E26 A;  1DYR A;  2FZI A;  3DAT A;  3E0B A;  3NZD A;  3DG8 A;  4KJL A;  2FZJ A;  4EIZ A;  3JTW A;  3TQA A;  1VDR A;  1IA4 A;  3JSU A;  4GH8 A;  1DR4 A;  3OAF A;  1DRF A;  2CIG A;  3INV A;  3M09 A;  3QYL A;  1IA1 A;  2QK8 A;  1KLK A;  4ELF A;  4EJ1 A;  3EEK A;  4KY4 A;  1RA2 A;  2BLB A;  1DLS A;  2HXV A;  3SR5 X;  3UM8 A;  3JWC A;  4M7V A;  3KJS A;  1KMS A;  3TD8 A;  1RG7 A;  1DG8 A;  4M6J A;  4QJZ D;  5HVE A;  1S3Y A;  5EAJ A;  1S3V A;  5ECC A;  4ELH A;  4LAE X;  4PDJ A;  4M6L A;  1HFQ A;  2BL9 A;  4LAH X;  1RD7 A;  3I8A X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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