2BLBA

X-ray crystal structure of plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
237
structure length
217
Chain Sequence
ENLSDVFDIYAICACCKVAPTSAGTKNEPFSPRTFRGLGNKGTLPWKCNSVDMKYFSSVTTYVDESKYEKLKWKRERYLRMEASKLQNVVVMGRSSWESIPKQYKPLPNRINVVLSKTLTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYRECLSRNLIKQIYFTRINGAYPCDVFFPEFDESEFRVTSVSEVYNSKGTTLDFLVYSKV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Plasmodium vivax
molecule keywords DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE
total genus 62
structure length 217
sequence length 237
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2005-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 2blbA00
4QLEA 4LAEX 3KY8A 1JOMA 4KFJA 7DFRA 3NZAX 1DR6A 4DPHA 4FGGA 4XT4A 2XW7A 3F0UX 1CD2A 1U70A 4PSYA 3JSUA 2HQPA 1DREA 4G8ZX 5DXVA 5HVEA 1PDBA 3EEJA 3F8ZA 2W9TA 3ZPCA 4XECX 3UM8A 3S3VA 1S3YA 2C2TA 5DFRA 4PTHA 3SGYA 3SRUX 3TQ9A 3K2HA 1DLRA 4EIZA 4H98A 2W3MA 3QFXA 5JG0X 5HQZA 4XT6A 1PD9A 1RX6A 2ANQA 2BLAA 4QJCA 2HXVA 3F0XX 5ECXA 2GD9A 3QL3A 1RX4A 2AZNA 1S3UA 2KGKA 3QYOA 1RA8A 8DFRA 4KM0A 1DYRA 1AOEA 3KJRA 3SQYX 4KM2A 4KD7A 3NU0A 3EELA 3RG9A 3OAFA 4FHBA 3FRBX 2FZJA 3DRCA 4NX6A 3RO9A 5HPBA 3FRAX 3FREX 3M08A 3ROAA 1TDRA 3F0VX 1RX9A 4H95A 2B3ZA 4KY4A 5JA3A 1DISA 1E26A 4DDRA 4KNEA 3NZDA 4P66A 1DHIA 3EIGA 2ZZAA 3QLYA 4Q67A 4Q0DA 1DRBA 1M79A 3Q1HA 1RA1A 3SH2A 3F8YA 3K74A 1BOZA 1RB3A 4H97A 5HVBA 1ZDRA 3NXRA 4Q6AA 3UM5A 4QLFA 4CD2A 1DYHA 3TD8A 5CC9A 5HT4A 2ANOA 1AI9A 4Q0EA 3FQOA 1AO8A 3KJSA 3I3RA 1HFQA 3I8AX 3IROA 3INVA 3K47A 1MVTA 1J3KA 3GHCA 4X5FA 3FQVA 3NZBX 3IRNA 3FY8X 1DAJA 2LF1A 3QLSA 5HT5A 2C2SA 1JOLA 3IA5A 4GH8A 3LG4A 4FGHA 3EEMA 4PDJA 2W9SA 1DR1A 2W9HA 1LY3A 3GI2A 5CCCA 4HOGA 1KMSA 1U72A 1OHKA 3IRMA 5HUIA 3TQBA 2QK8A 1RA3A 4QI9A 4KL9A 1DG8A 4KAKA 2W3WA 1MVSA 4ELGA 1DR5A 4LAGX 1RC4A 3SR5X 2CIGA 3FQ0A 1RX1A 2BLBA 3FYVX 2W3AA 3DGAA 4TU5X 1IA4A 3JWFA 1RX3A 3SRQX 5U27A 3D80A 3FY9X 1LY4A 4KY8A 3FYWX 5HI6A 1PD8A 4G3MA 1KMVA 4HOFA 3E0BA 2BL9A 2W3BA 3FL8A 1RH3A 4PSTA 5HSRA 1VDRA 3NXYA 4P3RA 3K45A 3TQAA 4XE6X 3JWMA 3CL9A 2O7PA 4X5JA 1YHOA 2FZHA 4DFRA 1IA1A 2CD2A 1DDSA 1DYJA 1CZ3A 3F91A 4IXFX 4KJLA 4M6KA 2INQA 5HQYA 3KGYA 3NXXA 3L3RA 2FZIA 3GYFA 3QG2A 4IXED 4I13A 3NXOA 1KLKA 4DP3A 1DF7A 4NX7A 4KEBA 2JYBA 3FQZA 4XT7A 4XT5A 4QJZD 3D84X 3GHVA 3JW3A 1DR2A 4ELFA 3DL6A 1DR3A 1J3JA 3M09A 4DPDA 2OIPA 1QZFA 4X5GA 3R33A 1DHJA 1RA9A 3QLWA 4M2XA 1DIUA 1DR4A 3S7AA 3FRDX 3VCOA 3CSEA 1HFPA 1J3IA 4RGCA 3NZ9X 4I1NA 2BLCA 4KLXA 4P68A 1LUDA 1SEJA 4QLGA 3NZCX 4XT8A 5HF2X 4HA9A 3NXTA 3F0QX 4X5HA 2DHFA 4PTJA 4ELEA 3KFYA 4EJ1A 2L28A 3DG8A 1VJ3A 4M6LA 1S3VA 3DFRA 3DAUA 3QL0A 3SRRX 3S9UA 2P4GA 5HSUA 3FRFX 1DG5A 1S3WA 4KJJA 2W9GA 3IX9A 4EIGA 3QLZA 3ZPGA 3F0BX 4H96A 1RF7A 3JVXA 1DR7A 5E8QA 3EX8A 3JTWA 4EILA 3QGTA 4HA7A 3FQFA 1DYIA 4PSSA 3GHWA 1RA2A 2OBCA 4M7UA 1RX8A 5ECCA 2HM9A 4KJKA 4X5IA 1DRFA 1DG7A 3FS6A 1IA2A 3QLRA 3HJ3A 4M6JA 4ECKA 2H2QA 3JW5A 4M7VA 3TQ8A 2D0KA 1DLSA 2G6VA 3SA1A 3CD2A 1U71A 3QLXA 1DDRA 5HF0X 3NXVA 3SRSX 1BZFA 4ELBA 3EEKA 5EAJA 4QHVA 1DRAA 3FQCA 3NZ6X 4G95A 4P3QA 3DATA 3N0HA 1HFRA 3CLBA 4OR7A 1RX5A 3JWCA 1JUVA 5U26A 4ELHA 1RG7A 3OCHA 4XRBA 4LEKX 1IA3A 1RX2A 4KYAA 1D1GA 4LAHX 1OHJA 3NRRA 3JWKA 1RB2A 1RE7A 2W3VA 3QYLA 3UM6A 4KBNA 3SRWX 3HBBA 1DHFA 3IA4A 2DRCA 1M7AA 4IXGX 3SAIA 1RX7A 4HOEA 6DFRA 1DRHA 5FDAA 2D5NA 3DL5A 2ITHA 3NTZA 3F0SX 1M78A 3FL9A 1RD7A 4OSGA 3SA2A
chains in the Genus database with same CATH superfamily
4QLEA 4LAEX 3KY8A 1JOMA 4KFJA 7DFRA 3NZAX 1DR6A 4DPHA 4FGGA 4XT4A 2XW7A 3F0UX 1CD2A 1U70A 4PSYA 3JSUA 2HQPA 1DREA 4G8ZX 5DXVA 5HVEA 1PDBA 3EEJA 3F8ZA 2W9TA 3ZPCA 4XECX 3UM8A 3S3VA 1S3YA 2C2TA 5DFRA 4PTHA 3SGYA 3SRUX 3TQ9A 3K2HA 1DLRA 4EIZA 4H98A 2W3MA 3QFXA 5JG0X 5HQZA 4XT6A 1PD9A 1RX6A 2ANQA 2BLAA 4QJCA 2HXVA 3F0XX 5ECXA 2GD9A 3QL3A 1RX4A 2AZNA 1S3UA 2KGKA 3QYOA 1RA8A 8DFRA 4KM0A 1DYRA 1AOEA 3KJRA 3SQYX 4KM2A 4KD7A 3NU0A 3EELA 3RG9A 3OAFA 4FHBA 3FRBX 2FZJA 3DRCA 4NX6A 3RO9A 5HPBA 3FRAX 3FREX 3M08A 3ROAA 1TDRA 3F0VX 1RX9A 4H95A 2B3ZA 4KY4A 5JA3A 1DISA 1E26A 4DDRA 4KNEA 3NZDA 4P66A 1DHIA 3EIGA 2ZZAA 3QLYA 4Q67A 4Q0DA 1DRBA 1M79A 3Q1HA 1RA1A 3SH2A 3F8YA 3K74A 1BOZA 1RB3A 4H97A 5HVBA 1ZDRA 3NXRA 4Q6AA 3UM5A 4QLFA 4CD2A 1DYHA 3TD8A 5CC9A 5HT4A 2ANOA 1AI9A 4Q0EA 3FQOA 1AO8A 3KJSA 3I3RA 1HFQA 3I8AX 3IROA 3INVA 3K47A 1MVTA 1J3KA 3GHCA 4X5FA 3FQVA 3NZBX 3IRNA 3FY8X 1DAJA 2LF1A 3QLSA 5HT5A 2C2SA 1JOLA 3IA5A 4GH8A 3LG4A 4FGHA 3EEMA 4PDJA 2W9SA 1DR1A 2W9HA 1LY3A 3GI2A 5CCCA 4HOGA 1KMSA 1U72A 1OHKA 3IRMA 5HUIA 3TQBA 2QK8A 1RA3A 4QI9A 4KL9A 1DG8A 4KAKA 2W3WA 1MVSA 4ELGA 1DR5A 4LAGX 1RC4A 3SR5X 2CIGA 3FQ0A 1RX1A 2BLBA 3FYVX 2W3AA 3DGAA 4TU5X 1IA4A 3JWFA 1RX3A 3SRQX 5U27A 3D80A 3FY9X 1LY4A 4KY8A 3FYWX 5HI6A 1PD8A 4G3MA 1KMVA 4HOFA 3E0BA 2BL9A 2W3BA 3FL8A 1RH3A 4PSTA 5HSRA 1VDRA 3NXYA 4P3RA 3K45A 3TQAA 4XE6X 3JWMA 3CL9A 2O7PA 4X5JA 1YHOA 2FZHA 4DFRA 1IA1A 2CD2A 1DDSA 1DYJA 1CZ3A 3F91A 4IXFX 4KJLA 4M6KA 2INQA 5HQYA 3KGYA 3NXXA 3L3RA 2FZIA 3GYFA 3QG2A 4IXED 4I13A 3NXOA 1KLKA 4DP3A 1DF7A 4NX7A 4KEBA 2JYBA 3FQZA 4XT7A 4XT5A 4QJZD 3D84X 3GHVA 3JW3A 1DR2A 4ELFA 3DL6A 1DR3A 1J3JA 3M09A 4DPDA 2OIPA 1QZFA 4X5GA 3R33A 1DHJA 1RA9A 3QLWA 4M2XA 1DIUA 1DR4A 3S7AA 3FRDX 3VCOA 3CSEA 1HFPA 1J3IA 4RGCA 3NZ9X 4I1NA 2BLCA 4KLXA 4P68A 1LUDA 1SEJA 4QLGA 3NZCX 4XT8A 5HF2X 4HA9A 3NXTA 3F0QX 4X5HA 2DHFA 4PTJA 4ELEA 3KFYA 4EJ1A 2L28A 3DG8A 1VJ3A 4M6LA 1S3VA 3DFRA 3DAUA 3QL0A 3SRRX 3S9UA 2P4GA 5HSUA 3FRFX 1DG5A 1S3WA 4KJJA 2W9GA 3IX9A 4EIGA 3QLZA 3ZPGA 3F0BX 4H96A 1RF7A 3JVXA 1DR7A 5E8QA 3EX8A 3JTWA 4EILA 3QGTA 4HA7A 3FQFA 1DYIA 4PSSA 3GHWA 1RA2A 2OBCA 4M7UA 1RX8A 5ECCA 2HM9A 4KJKA 4X5IA 1DRFA 1DG7A 3FS6A 1IA2A 3QLRA 3HJ3A 4M6JA 4ECKA 2H2QA 3JW5A 4M7VA 3TQ8A 2D0KA 1DLSA 2G6VA 3SA1A 3CD2A 1U71A 3QLXA 1DDRA 5HF0X 3NXVA 3SRSX 1BZFA 4ELBA 3EEKA 5EAJA 4QHVA 1DRAA 3FQCA 3NZ6X 4G95A 4P3QA 3DATA 3N0HA 1HFRA 3CLBA 4OR7A 1RX5A 3JWCA 1JUVA 5U26A 4ELHA 1RG7A 3OCHA 4XRBA 4LEKX 1IA3A 1RX2A 4KYAA 1D1GA 4LAHX 1OHJA 3NRRA 3JWKA 1RB2A 1RE7A 2W3VA 3QYLA 3UM6A 4KBNA 3SRWX 3HBBA 1DHFA 3IA4A 2DRCA 1M7AA 4IXGX 3SAIA 1RX7A 4HOEA 6DFRA 1DRHA 5FDAA 2D5NA 3DL5A 2ITHA 3NTZA 3F0SX 1M78A 3FL9A 1RD7A 4OSGA 3SA2A
chains in the Genus database with same CATH topology
4QLEA 4LAEX 3KY8A 1JOMA 4KFJA 7DFRA 3NZAX 1DR6A 4DPHA 4FGGA 4XT4A 2XW7A 3F0UX 1CD2A 1U70A 4PSYA 3JSUA 2HQPA 1DREA 4G8ZX 5DXVA 5HVEA 1PDBA 3EEJA 3F8ZA 2W9TA 3ZPCA 4XECX 3UM8A 3S3VA 1S3YA 2C2TA 5DFRA 4PTHA 3SGYA 3SRUX 3TQ9A 3K2HA 1DLRA 4EIZA 4H98A 2W3MA 3QFXA 5JG0X 5HQZA 4XT6A 1PD9A 1RX6A 2ANQA 2BLAA 4QJCA 2HXVA 3F0XX 5ECXA 2GD9A 3QL3A 1RX4A 2AZNA 1S3UA 2KGKA 3QYOA 1RA8A 8DFRA 4KM0A 1DYRA 1AOEA 3KJRA 3SQYX 4KM2A 4KD7A 3NU0A 3EELA 3RG9A 3OAFA 4FHBA 3FRBX 2FZJA 3DRCA 4NX6A 3RO9A 5HPBA 3FRAX 3FREX 3M08A 3ROAA 1TDRA 3F0VX 1RX9A 4H95A 2B3ZA 4KY4A 5JA3A 1DISA 1E26A 4DDRA 4KNEA 3NZDA 4P66A 1DHIA 3EIGA 2ZZAA 3QLYA 4Q67A 4Q0DA 1DRBA 1M79A 3Q1HA 1RA1A 3SH2A 3F8YA 3K74A 1BOZA 1RB3A 4H97A 5HVBA 1ZDRA 3NXRA 4Q6AA 3UM5A 4QLFA 4CD2A 1DYHA 3TD8A 5CC9A 5HT4A 2ANOA 1AI9A 4Q0EA 3FQOA 1AO8A 3KJSA 3I3RA 1HFQA 3I8AX 3IROA 3INVA 3K47A 1MVTA 1J3KA 3GHCA 4X5FA 3FQVA 3NZBX 3IRNA 3FY8X 1DAJA 2LF1A 3QLSA 5HT5A 2C2SA 1JOLA 3IA5A 4GH8A 3LG4A 4FGHA 3EEMA 4PDJA 2W9SA 1DR1A 2W9HA 1LY3A 3GI2A 5CCCA 4HOGA 1KMSA 1U72A 1OHKA 3IRMA 5HUIA 3TQBA 2QK8A 1RA3A 4QI9A 4KL9A 1DG8A 4KAKA 2W3WA 1MVSA 4ELGA 1DR5A 4LAGX 1RC4A 3SR5X 2CIGA 3FQ0A 1RX1A 2BLBA 3FYVX 2W3AA 3DGAA 4TU5X 1IA4A 3JWFA 1RX3A 3SRQX 5U27A 3D80A 3FY9X 1LY4A 4KY8A 3FYWX 5HI6A 1PD8A 4G3MA 1KMVA 4HOFA 3E0BA 2BL9A 2W3BA 3FL8A 1RH3A 4PSTA 5HSRA 1VDRA 3NXYA 4P3RA 3K45A 3TQAA 4XE6X 3JWMA 3CL9A 2O7PA 4X5JA 1YHOA 2FZHA 4DFRA 1IA1A 2CD2A 1DDSA 1DYJA 1CZ3A 3F91A 4IXFX 4KJLA 4M6KA 2INQA 5HQYA 3KGYA 3NXXA 3L3RA 2FZIA 3GYFA 3QG2A 4IXED 4I13A 3NXOA 1KLKA 4DP3A 1DF7A 4NX7A 4KEBA 2JYBA 3FQZA 4XT7A 4XT5A 4QJZD 3D84X 3GHVA 3JW3A 1DR2A 4ELFA 3DL6A 1DR3A 1J3JA 3M09A 4DPDA 2OIPA 1QZFA 4X5GA 3R33A 1DHJA 1RA9A 3QLWA 4M2XA 1DIUA 1DR4A 3S7AA 3FRDX 3VCOA 3CSEA 1HFPA 1J3IA 4RGCA 3NZ9X 4I1NA 2BLCA 4KLXA 4P68A 1LUDA 1SEJA 4QLGA 3NZCX 4XT8A 5HF2X 4HA9A 3NXTA 3F0QX 4X5HA 2DHFA 4PTJA 4ELEA 3KFYA 4EJ1A 2L28A 3DG8A 1VJ3A 4M6LA 1S3VA 3DFRA 3DAUA 3QL0A 3SRRX 3S9UA 2P4GA 5HSUA 3FRFX 1DG5A 1S3WA 4KJJA 2W9GA 3IX9A 4EIGA 3QLZA 3ZPGA 3F0BX 4H96A 1RF7A 3JVXA 1DR7A 5E8QA 3EX8A 3JTWA 4EILA 3QGTA 4HA7A 3FQFA 1DYIA 4PSSA 3GHWA 1RA2A 2OBCA 4M7UA 1RX8A 5ECCA 2HM9A 4KJKA 4X5IA 1DRFA 1DG7A 3FS6A 1IA2A 3QLRA 3HJ3A 4M6JA 4ECKA 2H2QA 3JW5A 4M7VA 3TQ8A 2D0KA 1DLSA 2G6VA 3SA1A 3CD2A 1U71A 3QLXA 1DDRA 5HF0X 3NXVA 3SRSX 1BZFA 4ELBA 3EEKA 5EAJA 4QHVA 1DRAA 3FQCA 3NZ6X 4G95A 4P3QA 3DATA 3N0HA 1HFRA 3CLBA 4OR7A 1RX5A 3JWCA 1JUVA 5U26A 4ELHA 1RG7A 3OCHA 4XRBA 4LEKX 1IA3A 1RX2A 4KYAA 1D1GA 4LAHX 1OHJA 3NRRA 3JWKA 1RB2A 1RE7A 2W3VA 3QYLA 3UM6A 4KBNA 3SRWX 3HBBA 1DHFA 3IA4A 2DRCA 1M7AA 4IXGX 3SAIA 1RX7A 4HOEA 6DFRA 1DRHA 5FDAA 2D5NA 3DL5A 2ITHA 3NTZA 3F0SX 1M78A 3FL9A 1RD7A 4OSGA 3SA2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QLE A;  4LAE X;  3KY8 A;  1JOM A;  4KFJ A;  7DFR A;  3NZA X;  1DR6 A;  4DPH A;  4FGG A;  4XT4 A;  2XW7 A;  3F0U X;  1CD2 A;  1U70 A;  4PSY A;  3JSU A;  2HQP A;  1DRE A;  4G8Z X;  5DXV A;  5HVE A;  1PDB A;  3EEJ A;  3F8Z A;  2W9T A;  3ZPC A;  4XEC X;  3UM8 A;  3S3V A;  1S3Y A;  2C2T A;  5DFR A;  4PTH A;  3SGY A;  3SRU X;  3TQ9 A;  3K2H A;  1DLR A;  4EIZ A;  4H98 A;  2W3M A;  3QFX A;  5JG0 X;  5HQZ A;  4XT6 A;  1PD9 A;  1RX6 A;  2ANQ A;  2BLA A;  4QJC A;  2HXV A;  3F0X X;  5ECX A;  2GD9 A;  3QL3 A;  1RX4 A;  2AZN A;  1S3U A;  2KGK A;  3QYO A;  1RA8 A;  8DFR A;  4KM0 A;  1DYR A;  1AOE A;  3KJR A;  3SQY X;  4KM2 A;  4KD7 A;  3NU0 A;  3EEL A;  3RG9 A;  3OAF A;  4FHB A;  3FRB X;  2FZJ A;  3DRC A;  4NX6 A;  3RO9 A;  5HPB A;  3FRA X;  3FRE X;  3M08 A;  3ROA A;  1TDR A;  3F0V X;  1RX9 A;  4H95 A;  2B3Z A;  4KY4 A;  5JA3 A;  1DIS A;  1E26 A;  4DDR A;  4KNE A;  3NZD A;  4P66 A;  1DHI A;  3EIG A;  2ZZA A;  3QLY A;  4Q67 A;  4Q0D A;  1DRB A;  1M79 A;  3Q1H A;  1RA1 A;  3SH2 A;  3F8Y A;  3K74 A;  1BOZ A;  1RB3 A;  4H97 A;  5HVB A;  1ZDR A;  3NXR A;  4Q6A A;  3UM5 A;  4QLF A;  4CD2 A;  1DYH A;  3TD8 A;  5CC9 A;  5HT4 A;  2ANO A;  1AI9 A;  4Q0E A;  3FQO A;  1AO8 A;  3KJS A;  3I3R A;  1HFQ A;  3I8A X;  3IRO A;  3INV A;  3K47 A;  1MVT A;  1J3K A;  3GHC A;  4X5F A;  3FQV A;  3NZB X;  3IRN A;  3FY8 X;  1DAJ A;  2LF1 A;  3QLS A;  5HT5 A;  2C2S A;  1JOL A;  3IA5 A;  4GH8 A;  3LG4 A;  4FGH A;  3EEM A;  4PDJ A;  2W9S A;  1DR1 A;  2W9H A;  1LY3 A;  3GI2 A;  5CCC A;  4HOG A;  1KMS A;  1U72 A;  1OHK A;  3IRM A;  5HUI A;  3TQB A;  2QK8 A;  1RA3 A;  4QI9 A;  4KL9 A;  1DG8 A;  4KAK A;  2W3W A;  1MVS A;  4ELG A;  1DR5 A;  4LAG X;  1RC4 A;  3SR5 X;  2CIG A;  3FQ0 A;  1RX1 A;  2BLB A;  3FYV X;  2W3A A;  3DGA A;  4TU5 X;  1IA4 A;  3JWF A;  1RX3 A;  3SRQ X;  5U27 A;  3D80 A;  3FY9 X;  1LY4 A;  4KY8 A;  3FYW X;  5HI6 A;  1PD8 A;  4G3M A;  1KMV A;  4HOF A;  3E0B A;  2BL9 A;  2W3B A;  3FL8 A;  1RH3 A;  4PST A;  5HSR A;  1VDR A;  3NXY A;  4P3R A;  3K45 A;  3TQA A;  4XE6 X;  3JWM A;  3CL9 A;  2O7P A;  4X5J A;  1YHO A;  2FZH A;  4DFR A;  1IA1 A;  2CD2 A;  1DDS A;  1DYJ A;  1CZ3 A;  3F91 A;  4IXF X;  4KJL A;  4M6K A;  2INQ A;  5HQY A;  3KGY A;  3NXX A;  3L3R A;  2FZI A;  3GYF A;  3QG2 A;  4IXE D;  4I13 A;  3NXO A;  1KLK A;  4DP3 A;  1DF7 A;  4NX7 A;  4KEB A;  2JYB A;  3FQZ A;  4XT7 A;  4XT5 A;  4QJZ D;  3D84 X;  3GHV A;  3JW3 A;  1DR2 A;  4ELF A;  3DL6 A;  1DR3 A;  1J3J A;  3M09 A;  4DPD A;  2OIP A;  1QZF A;  4X5G A;  3R33 A;  1DHJ A;  1RA9 A;  3QLW A;  4M2X A;  1DIU A;  1DR4 A;  3S7A A;  3FRD X;  3VCO A;  3CSE A;  1HFP A;  1J3I A;  4RGC A;  3NZ9 X;  4I1N A;  2BLC A;  4KLX A;  4P68 A;  1LUD A;  1SEJ A;  4QLG A;  3NZC X;  4XT8 A;  5HF2 X;  4HA9 A;  3NXT A;  3F0Q X;  4X5H A;  2DHF A;  4PTJ A;  4ELE A;  3KFY A;  4EJ1 A;  2L28 A;  3DG8 A;  1VJ3 A;  4M6L A;  1S3V A;  3DFR A;  3DAU A;  3QL0 A;  3SRR X;  3S9U A;  2P4G A;  5HSU A;  3FRF X;  1DG5 A;  1S3W A;  4KJJ A;  2W9G A;  3IX9 A;  4EIG A;  3QLZ A;  3ZPG A;  3F0B X;  4H96 A;  1RF7 A;  3JVX A;  1DR7 A;  5E8Q A;  3EX8 A;  3JTW A;  4EIL A;  3QGT A;  4HA7 A;  3FQF A;  1DYI A;  4PSS A;  3GHW A;  1RA2 A;  2OBC A;  4M7U A;  1RX8 A;  5ECC A;  2HM9 A;  4KJK A;  4X5I A;  1DRF A;  1DG7 A;  3FS6 A;  1IA2 A;  3QLR A;  3HJ3 A;  4M6J A;  4ECK A;  2H2Q A;  3JW5 A;  4M7V A;  3TQ8 A;  2D0K A;  1DLS A;  2G6V A;  3SA1 A;  3CD2 A;  1U71 A;  3QLX A;  1DDR A;  5HF0 X;  3NXV A;  3SRS X;  1BZF A;  4ELB A;  3EEK A;  5EAJ A;  4QHV A;  1DRA A;  3FQC A;  3NZ6 X;  4G95 A;  4P3Q A;  3DAT A;  3N0H A;  1HFR A;  3CLB A;  4OR7 A;  1RX5 A;  3JWC A;  1JUV A;  5U26 A;  4ELH A;  1RG7 A;  3OCH A;  4XRB A;  4LEK X;  1IA3 A;  1RX2 A;  4KYA A;  1D1G A;  4LAH X;  1OHJ A;  3NRR A;  3JWK A;  1RB2 A;  1RE7 A;  2W3V A;  3QYL A;  3UM6 A;  4KBN A;  3SRW X;  3HBB A;  1DHF A;  3IA4 A;  2DRC A;  1M7A A;  4IXG X;  3SAI A;  1RX7 A;  4HOE A;  6DFR A;  1DRH A;  5FDA A;  2D5N A;  3DL5 A;  2ITH A;  3NTZ A;  3F0S X;  1M78 A;  3FL9 A;  1RD7 A;  4OSG A;  3SA2 A; 
#chains in the Genus database with same CATH topology
 4QLE A;  4LAE X;  3KY8 A;  1JOM A;  4KFJ A;  7DFR A;  3NZA X;  1DR6 A;  4DPH A;  4FGG A;  4XT4 A;  2XW7 A;  3F0U X;  1CD2 A;  1U70 A;  4PSY A;  3JSU A;  2HQP A;  1DRE A;  4G8Z X;  5DXV A;  5HVE A;  1PDB A;  3EEJ A;  3F8Z A;  2W9T A;  3ZPC A;  4XEC X;  3UM8 A;  3S3V A;  1S3Y A;  2C2T A;  5DFR A;  4PTH A;  3SGY A;  3SRU X;  3TQ9 A;  3K2H A;  1DLR A;  4EIZ A;  4H98 A;  2W3M A;  3QFX A;  5JG0 X;  5HQZ A;  4XT6 A;  1PD9 A;  1RX6 A;  2ANQ A;  2BLA A;  4QJC A;  2HXV A;  3F0X X;  5ECX A;  2GD9 A;  3QL3 A;  1RX4 A;  2AZN A;  1S3U A;  2KGK A;  3QYO A;  1RA8 A;  8DFR A;  4KM0 A;  1DYR A;  1AOE A;  3KJR A;  3SQY X;  4KM2 A;  4KD7 A;  3NU0 A;  3EEL A;  3RG9 A;  3OAF A;  4FHB A;  3FRB X;  2FZJ A;  3DRC A;  4NX6 A;  3RO9 A;  5HPB A;  3FRA X;  3FRE X;  3M08 A;  3ROA A;  1TDR A;  3F0V X;  1RX9 A;  4H95 A;  2B3Z A;  4KY4 A;  5JA3 A;  1DIS A;  1E26 A;  4DDR A;  4KNE A;  3NZD A;  4P66 A;  1DHI A;  3EIG A;  2ZZA A;  3QLY A;  4Q67 A;  4Q0D A;  1DRB A;  1M79 A;  3Q1H A;  1RA1 A;  3SH2 A;  3F8Y A;  3K74 A;  1BOZ A;  1RB3 A;  4H97 A;  5HVB A;  1ZDR A;  3NXR A;  4Q6A A;  3UM5 A;  4QLF A;  4CD2 A;  1DYH A;  3TD8 A;  5CC9 A;  5HT4 A;  2ANO A;  1AI9 A;  4Q0E A;  3FQO A;  1AO8 A;  3KJS A;  3I3R A;  1HFQ A;  3I8A X;  3IRO A;  3INV A;  3K47 A;  1MVT A;  1J3K A;  3GHC A;  4X5F A;  3FQV A;  3NZB X;  3IRN A;  3FY8 X;  1DAJ A;  2LF1 A;  3QLS A;  5HT5 A;  2C2S A;  1JOL A;  3IA5 A;  4GH8 A;  3LG4 A;  4FGH A;  3EEM A;  4PDJ A;  2W9S A;  1DR1 A;  2W9H A;  1LY3 A;  3GI2 A;  5CCC A;  4HOG A;  1KMS A;  1U72 A;  1OHK A;  3IRM A;  5HUI A;  3TQB A;  2QK8 A;  1RA3 A;  4QI9 A;  4KL9 A;  1DG8 A;  4KAK A;  2W3W A;  1MVS A;  4ELG A;  1DR5 A;  4LAG X;  1RC4 A;  3SR5 X;  2CIG A;  3FQ0 A;  1RX1 A;  2BLB A;  3FYV X;  2W3A A;  3DGA A;  4TU5 X;  1IA4 A;  3JWF A;  1RX3 A;  3SRQ X;  5U27 A;  3D80 A;  3FY9 X;  1LY4 A;  4KY8 A;  3FYW X;  5HI6 A;  1PD8 A;  4G3M A;  1KMV A;  4HOF A;  3E0B A;  2BL9 A;  2W3B A;  3FL8 A;  1RH3 A;  4PST A;  5HSR A;  1VDR A;  3NXY A;  4P3R A;  3K45 A;  3TQA A;  4XE6 X;  3JWM A;  3CL9 A;  2O7P A;  4X5J A;  1YHO A;  2FZH A;  4DFR A;  1IA1 A;  2CD2 A;  1DDS A;  1DYJ A;  1CZ3 A;  3F91 A;  4IXF X;  4KJL A;  4M6K A;  2INQ A;  5HQY A;  3KGY A;  3NXX A;  3L3R A;  2FZI A;  3GYF A;  3QG2 A;  4IXE D;  4I13 A;  3NXO A;  1KLK A;  4DP3 A;  1DF7 A;  4NX7 A;  4KEB A;  2JYB A;  3FQZ A;  4XT7 A;  4XT5 A;  4QJZ D;  3D84 X;  3GHV A;  3JW3 A;  1DR2 A;  4ELF A;  3DL6 A;  1DR3 A;  1J3J A;  3M09 A;  4DPD A;  2OIP A;  1QZF A;  4X5G A;  3R33 A;  1DHJ A;  1RA9 A;  3QLW A;  4M2X A;  1DIU A;  1DR4 A;  3S7A A;  3FRD X;  3VCO A;  3CSE A;  1HFP A;  1J3I A;  4RGC A;  3NZ9 X;  4I1N A;  2BLC A;  4KLX A;  4P68 A;  1LUD A;  1SEJ A;  4QLG A;  3NZC X;  4XT8 A;  5HF2 X;  4HA9 A;  3NXT A;  3F0Q X;  4X5H A;  2DHF A;  4PTJ A;  4ELE A;  3KFY A;  4EJ1 A;  2L28 A;  3DG8 A;  1VJ3 A;  4M6L A;  1S3V A;  3DFR A;  3DAU A;  3QL0 A;  3SRR X;  3S9U A;  2P4G A;  5HSU A;  3FRF X;  1DG5 A;  1S3W A;  4KJJ A;  2W9G A;  3IX9 A;  4EIG A;  3QLZ A;  3ZPG A;  3F0B X;  4H96 A;  1RF7 A;  3JVX A;  1DR7 A;  5E8Q A;  3EX8 A;  3JTW A;  4EIL A;  3QGT A;  4HA7 A;  3FQF A;  1DYI A;  4PSS A;  3GHW A;  1RA2 A;  2OBC A;  4M7U A;  1RX8 A;  5ECC A;  2HM9 A;  4KJK A;  4X5I A;  1DRF A;  1DG7 A;  3FS6 A;  1IA2 A;  3QLR A;  3HJ3 A;  4M6J A;  4ECK A;  2H2Q A;  3JW5 A;  4M7V A;  3TQ8 A;  2D0K A;  1DLS A;  2G6V A;  3SA1 A;  3CD2 A;  1U71 A;  3QLX A;  1DDR A;  5HF0 X;  3NXV A;  3SRS X;  1BZF A;  4ELB A;  3EEK A;  5EAJ A;  4QHV A;  1DRA A;  3FQC A;  3NZ6 X;  4G95 A;  4P3Q A;  3DAT A;  3N0H A;  1HFR A;  3CLB A;  4OR7 A;  1RX5 A;  3JWC A;  1JUV A;  5U26 A;  4ELH A;  1RG7 A;  3OCH A;  4XRB A;  4LEK X;  1IA3 A;  1RX2 A;  4KYA A;  1D1G A;  4LAH X;  1OHJ A;  3NRR A;  3JWK A;  1RB2 A;  1RE7 A;  2W3V A;  3QYL A;  3UM6 A;  4KBN A;  3SRW X;  3HBB A;  1DHF A;  3IA4 A;  2DRC A;  1M7A A;  4IXG X;  3SAI A;  1RX7 A;  4HOE A;  6DFR A;  1DRH A;  5FDA A;  2D5N A;  3DL5 A;  2ITH A;  3NTZ A;  3F0S X;  1M78 A;  3FL9 A;  1RD7 A;  4OSG A;  3SA2 A; 
#chains in the Genus database with same CATH homology
 4QLE A;  4LAE X;  3KY8 A;  1JOM A;  4KFJ A;  7DFR A;  3NZA X;  1DR6 A;  4DPH A;  4FGG A;  4XT4 A;  2XW7 A;  3F0U X;  1CD2 A;  1U70 A;  4PSY A;  3JSU A;  2HQP A;  1DRE A;  4G8Z X;  5DXV A;  5HVE A;  1PDB A;  3EEJ A;  3F8Z A;  2W9T A;  3ZPC A;  4XEC X;  3UM8 A;  3S3V A;  1S3Y A;  2C2T A;  5DFR A;  4PTH A;  3SGY A;  3SRU X;  3TQ9 A;  3K2H A;  1DLR A;  4EIZ A;  4H98 A;  2W3M A;  3QFX A;  5JG0 X;  5HQZ A;  4XT6 A;  1PD9 A;  1RX6 A;  2ANQ A;  2BLA A;  4QJC A;  2HXV A;  3F0X X;  5ECX A;  2GD9 A;  3QL3 A;  1RX4 A;  2AZN A;  1S3U A;  2KGK A;  3QYO A;  1RA8 A;  8DFR A;  4KM0 A;  1DYR A;  1AOE A;  3KJR A;  3SQY X;  4KM2 A;  4KD7 A;  3NU0 A;  3EEL A;  3RG9 A;  3OAF A;  4FHB A;  3FRB X;  2FZJ A;  3DRC A;  4NX6 A;  3RO9 A;  5HPB A;  3FRA X;  3FRE X;  3M08 A;  3ROA A;  1TDR A;  3F0V X;  1RX9 A;  4H95 A;  2B3Z A;  4KY4 A;  5JA3 A;  1DIS A;  1E26 A;  4DDR A;  4KNE A;  3NZD A;  4P66 A;  1DHI A;  3EIG A;  2ZZA A;  3QLY A;  4Q67 A;  4Q0D A;  1DRB A;  1M79 A;  3Q1H A;  1RA1 A;  3SH2 A;  3F8Y A;  3K74 A;  1BOZ A;  1RB3 A;  4H97 A;  5HVB A;  1ZDR A;  3NXR A;  4Q6A A;  3UM5 A;  4QLF A;  4CD2 A;  1DYH A;  3TD8 A;  5CC9 A;  5HT4 A;  2ANO A;  1AI9 A;  4Q0E A;  3FQO A;  1AO8 A;  3KJS A;  3I3R A;  1HFQ A;  3I8A X;  3IRO A;  3INV A;  3K47 A;  1MVT A;  1J3K A;  3GHC A;  4X5F A;  3FQV A;  3NZB X;  3IRN A;  3FY8 X;  1DAJ A;  2LF1 A;  3QLS A;  5HT5 A;  2C2S A;  1JOL A;  3IA5 A;  4GH8 A;  3LG4 A;  4FGH A;  3EEM A;  4PDJ A;  2W9S A;  1DR1 A;  2W9H A;  1LY3 A;  3GI2 A;  5CCC A;  4HOG A;  1KMS A;  1U72 A;  1OHK A;  3IRM A;  5HUI A;  3TQB A;  2QK8 A;  1RA3 A;  4QI9 A;  4KL9 A;  1DG8 A;  4KAK A;  2W3W A;  1MVS A;  4ELG A;  1DR5 A;  4LAG X;  1RC4 A;  3SR5 X;  2CIG A;  3FQ0 A;  1RX1 A;  2BLB A;  3FYV X;  2W3A A;  3DGA A;  4TU5 X;  1IA4 A;  3JWF A;  1RX3 A;  3SRQ X;  5U27 A;  3D80 A;  3FY9 X;  1LY4 A;  4KY8 A;  3FYW X;  5HI6 A;  1PD8 A;  4G3M A;  1KMV A;  4HOF A;  3E0B A;  2BL9 A;  2W3B A;  3FL8 A;  1RH3 A;  4PST A;  5HSR A;  1VDR A;  3NXY A;  4P3R A;  3K45 A;  3TQA A;  4XE6 X;  3JWM A;  3CL9 A;  2O7P A;  4X5J A;  1YHO A;  2FZH A;  4DFR A;  1IA1 A;  2CD2 A;  1DDS A;  1DYJ A;  1CZ3 A;  3F91 A;  4IXF X;  4KJL A;  4M6K A;  2INQ A;  5HQY A;  3KGY A;  3NXX A;  3L3R A;  2FZI A;  3GYF A;  3QG2 A;  4IXE D;  4I13 A;  3NXO A;  1KLK A;  4DP3 A;  1DF7 A;  4NX7 A;  4KEB A;  2JYB A;  3FQZ A;  4XT7 A;  4XT5 A;  4QJZ D;  3D84 X;  3GHV A;  3JW3 A;  1DR2 A;  4ELF A;  3DL6 A;  1DR3 A;  1J3J A;  3M09 A;  4DPD A;  2OIP A;  1QZF A;  4X5G A;  3R33 A;  1DHJ A;  1RA9 A;  3QLW A;  4M2X A;  1DIU A;  1DR4 A;  3S7A A;  3FRD X;  3VCO A;  3CSE A;  1HFP A;  1J3I A;  4RGC A;  3NZ9 X;  4I1N A;  2BLC A;  4KLX A;  4P68 A;  1LUD A;  1SEJ A;  4QLG A;  3NZC X;  4XT8 A;  5HF2 X;  4HA9 A;  3NXT A;  3F0Q X;  4X5H A;  2DHF A;  4PTJ A;  4ELE A;  3KFY A;  4EJ1 A;  2L28 A;  3DG8 A;  1VJ3 A;  4M6L A;  1S3V A;  3DFR A;  3DAU A;  3QL0 A;  3SRR X;  3S9U A;  2P4G A;  5HSU A;  3FRF X;  1DG5 A;  1S3W A;  4KJJ A;  2W9G A;  3IX9 A;  4EIG A;  3QLZ A;  3ZPG A;  3F0B X;  4H96 A;  1RF7 A;  3JVX A;  1DR7 A;  5E8Q A;  3EX8 A;  3JTW A;  4EIL A;  3QGT A;  4HA7 A;  3FQF A;  1DYI A;  4PSS A;  3GHW A;  1RA2 A;  2OBC A;  4M7U A;  1RX8 A;  5ECC A;  2HM9 A;  4KJK A;  4X5I A;  1DRF A;  1DG7 A;  3FS6 A;  1IA2 A;  3QLR A;  3HJ3 A;  4M6J A;  4ECK A;  2H2Q A;  3JW5 A;  4M7V A;  3TQ8 A;  2D0K A;  1DLS A;  2G6V A;  3SA1 A;  3CD2 A;  1U71 A;  3QLX A;  1DDR A;  5HF0 X;  3NXV A;  3SRS X;  1BZF A;  4ELB A;  3EEK A;  5EAJ A;  4QHV A;  1DRA A;  3FQC A;  3NZ6 X;  4G95 A;  4P3Q A;  3DAT A;  3N0H A;  1HFR A;  3CLB A;  4OR7 A;  1RX5 A;  3JWC A;  1JUV A;  5U26 A;  4ELH A;  1RG7 A;  3OCH A;  4XRB A;  4LEK X;  1IA3 A;  1RX2 A;  4KYA A;  1D1G A;  4LAH X;  1OHJ A;  3NRR A;  3JWK A;  1RB2 A;  1RE7 A;  2W3V A;  3QYL A;  3UM6 A;  4KBN A;  3SRW X;  3HBB A;  1DHF A;  3IA4 A;  2DRC A;  1M7A A;  4IXG X;  3SAI A;  1RX7 A;  4HOE A;  6DFR A;  1DRH A;  5FDA A;  2D5N A;  3DL5 A;  2ITH A;  3NTZ A;  3F0S X;  1M78 A;  3FL9 A;  1RD7 A;  4OSG A;  3SA2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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