2C2TA

Human dihydrofolate reductase complexed with nadph and 2,4-diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 54
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2005-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 2c2tA00
3NRRA 3UM5A 5HF2X 2W9TA 4IXGX 1RC4A 3SGYA 1IA3A 3F0SX 1QZFA 5HQYA 1DRAA 3FRDX 2AZNA 2ANOA 3RO9A 3F0QX 4X5GA 5E8QA 3ROAA 1DISA 5HPBA 1M7AA 3CSEA 3QLWA 1HFQA 1KMVA 1DLRA 5CCCA 2FZHA 3QGTA 5HT5A 4M7VA 4KY8A 3FRBX 4ELGA 3EX8A 3FQFA 1JOLA 4Q6AA 3NXXA 4EILA 4M6LA 3E0BA 5HVBA 4X5JA 3NXTA 2QK8A 4EIZA 3F0VX 3FY9X 4ELHA 2INQA 5JG0X 2P4GA 3F91A 4KD7A 2H2QA 3INVA 3DFRA 5ECXA 1DHFA 4Q0EA 1DRHA 1BZFA 1RX5A 3S9UA 3SR5X 1S3UA 3FL8A 4XRBA 3SA1A 2W9GA 3QLYA 3SA2A 2W9HA 3ZPCA 4H95A 3DAUA 1DHJA 4LAEX 1RA2A 3NU0A 1DR2A 4KFJA 3FYVX 3QYLA 3QLXA 2CIGA 4RGCA 4KM0A 4FGHA 4P66A 4GH8A 4HOGA 2OBCA 4G95A 5HT4A 3FREX 4XT5A 4HA9A 2BL9A 1SEJA 2BLBA 3TQAA 2ZZAA 4ELBA 3RG9A 1LUDA 1AOEA 1BOZA 3FS6A 3D80A 1DYHA 1RF7A 1U70A 3F0BX 4IXFX 3K2HA 4LAGX 3KJRA 4M6KA 1M78A 1DYRA 4IXED 3CLBA 3Q1HA 1RA1A 3SH2A 3FRFX 2FZJA 4QHVA 2CD2A 3KY8A 1ZDRA 1M79A 3TQBA 4ELFA 1RD7A 4QLFA 1DR6A 4PSYA 1DDRA 3UM6A 4CD2A 3R33A 2HM9A 4PDJA 3F0XX 5JA3A 3NXOA 1IA1A 1RE7A 3S3VA 4XE6X 4KYAA 2KGKA 3KJSA 3SQYX 3TD8A 1PD8A 1DYIA 1MVSA 3JTWA 3KFYA 4I13A 1IA4A 2O7PA 2HXVA 4KNEA 2W3BA 3FQCA 4XT7A 4HOEA 3FQOA 4KAKA 2LF1A 3DATA 3JWKA 3OCHA 4KEBA 3SRUX 3FL9A 3JWMA 4NX7A 3JWFA 5HI6A 3IA5A 4X5HA 5CC9A 4PSSA 1HFRA 2W3VA 1KLKA 3QLRA 2BLCA 2C2SA 4X5IA 3QG2A 5U27A 4XT6A 3KGYA 2OIPA 3QL0A 2C2TA 1OHKA 4M6JA 3GHCA 3CD2A 4P68A 5FDAA 2W9SA 5HF0X 4H98A 4KJJA 4FHBA 3HBBA 3QLZA 1AO8A 4P3RA 4DPHA 1E26A 3IRNA 7DFRA 1RB3A 3DG8A 4P3QA 1RX7A 2ANQA 3IRMA 1CD2A 3GHWA 1DDSA 1RX2A 3M09A 2GD9A 4M2XA 3QFXA 4ECKA 3HJ3A 4KL9A 1DR1A 3NTZA 3M08A 3DL6A 4QLGA 3JW5A 4DPDA 3JWCA 2D0KA 1LY4A 3IX9A 2ITHA 3NXYA 1U71A 1DF7A 3GHVA 5HSRA 4PTJA 1DR7A 3QLSA 1PDBA 1RB2A 6DFRA 4H96A 3GI2A 3K47A 1DR5A 3GYFA 3SAIA 1DG8A 4FGGA 3S7AA 2B3ZA 4EIGA 5EAJA 4I1NA 4QJZD 1VJ3A 3IROA 4XECX 1DR4A 4G3MA 4QI9A 1DRBA 3NZDA 4ELEA 1RA8A 4Q67A 4QJCA 3CL9A 1DHIA 4KJKA 3F8YA 2W3WA 1IA2A 1RX9A 3TQ8A 3FQZA 3FQVA 3FQ0A 2JYBA 4KLXA 3FRAX 4OSGA 4XT4A 4PTHA 3JVXA 3DGAA 4KY4A 3QL3A 3FYWX 1RA9A 3F8ZA 4KM2A 3K74A 5HVEA 2L28A 3K45A 1CZ3A 4G8ZX 5U26A 1DAJA 4XT8A 3NZCX 3ZPGA 3NZAX 1RX8A 3NXVA 1DR3A 4QLEA 1DYJA 1RX1A 4LAHX 1J3JA 1RH3A 1DIUA 3EEJA 1AI9A 4HA7A 3I3RA 4X5FA 5DFRA 1JOMA 3FY8X 1RG7A 1RX3A 2D5NA 5ECCA 5HQZA 3L3RA 1KMSA 3DRCA 3I8AX 1J3KA 2DRCA 5DXVA 4Q0DA 1MVTA 3NZBX 3OAFA 1RA3A 8DFRA 1RX4A 3N0HA 2FZIA 5HSUA 3JSUA 4KBNA 4DFRA 4EJ1A 1PD9A 3DL5A 1DG7A 1LY3A 3NXRA 3SRQX 3SRWX 1HFPA 1DG5A 4PSTA 4KJLA 4H97A 1OHJA 3EEKA 3EEMA 3NZ9X 1JUVA 1S3WA 4DP3A 2XW7A 1VDRA 4OR7A 4LEKX 1DLSA 3QYOA 2BLAA 3SRRX 2DHFA 1TDRA 5HUIA 1D1GA 3D84X 2HQPA 1YHOA 3NZ6X 4NX6A 1S3YA 3EELA 1RX6A 4TU5X 2W3AA 3TQ9A 1S3VA 4DDRA 3SRSX 1J3IA 3F0UX 3IA4A 3LG4A 2G6VA 4HOFA 1U72A 3JW3A 1DREA 3VCOA 3EIGA 2W3MA 1DRFA 3UM8A 4M7UA
chains in the Genus database with same CATH superfamily
3NRRA 3UM5A 5HF2X 2W9TA 4IXGX 1RC4A 3SGYA 1IA3A 3F0SX 1QZFA 5HQYA 1DRAA 3FRDX 2AZNA 2ANOA 3RO9A 3F0QX 4X5GA 5E8QA 3ROAA 1DISA 5HPBA 1M7AA 3CSEA 3QLWA 1HFQA 1KMVA 1DLRA 5CCCA 2FZHA 3QGTA 5HT5A 4M7VA 4KY8A 3FRBX 4ELGA 3EX8A 3FQFA 1JOLA 4Q6AA 3NXXA 4EILA 4M6LA 3E0BA 5HVBA 4X5JA 3NXTA 2QK8A 4EIZA 3F0VX 3FY9X 4ELHA 2INQA 5JG0X 2P4GA 3F91A 4KD7A 2H2QA 3INVA 3DFRA 5ECXA 1DHFA 4Q0EA 1DRHA 1BZFA 1RX5A 3S9UA 3SR5X 1S3UA 3FL8A 4XRBA 3SA1A 2W9GA 3QLYA 3SA2A 2W9HA 3ZPCA 4H95A 3DAUA 1DHJA 4LAEX 1RA2A 3NU0A 1DR2A 4KFJA 3FYVX 3QYLA 3QLXA 2CIGA 4RGCA 4KM0A 4FGHA 4P66A 4GH8A 4HOGA 2OBCA 4G95A 5HT4A 3FREX 4XT5A 4HA9A 2BL9A 1SEJA 2BLBA 3TQAA 2ZZAA 4ELBA 3RG9A 1LUDA 1AOEA 1BOZA 3FS6A 3D80A 1DYHA 1RF7A 1U70A 3F0BX 4IXFX 3K2HA 4LAGX 3KJRA 4M6KA 1M78A 1DYRA 4IXED 3CLBA 3Q1HA 1RA1A 3SH2A 3FRFX 2FZJA 4QHVA 2CD2A 3KY8A 1ZDRA 1M79A 3TQBA 4ELFA 1RD7A 4QLFA 1DR6A 4PSYA 1DDRA 3UM6A 4CD2A 3R33A 2HM9A 4PDJA 3F0XX 5JA3A 3NXOA 1IA1A 1RE7A 3S3VA 4XE6X 4KYAA 2KGKA 3KJSA 3SQYX 3TD8A 1PD8A 1DYIA 1MVSA 3JTWA 3KFYA 4I13A 1IA4A 2O7PA 2HXVA 4KNEA 2W3BA 3FQCA 4XT7A 4HOEA 3FQOA 4KAKA 2LF1A 3DATA 3JWKA 3OCHA 4KEBA 3SRUX 3FL9A 3JWMA 4NX7A 3JWFA 5HI6A 3IA5A 4X5HA 5CC9A 4PSSA 1HFRA 2W3VA 1KLKA 3QLRA 2BLCA 2C2SA 4X5IA 3QG2A 5U27A 4XT6A 3KGYA 2OIPA 3QL0A 2C2TA 1OHKA 4M6JA 3GHCA 3CD2A 4P68A 5FDAA 2W9SA 5HF0X 4H98A 4KJJA 4FHBA 3HBBA 3QLZA 1AO8A 4P3RA 4DPHA 1E26A 3IRNA 7DFRA 1RB3A 3DG8A 4P3QA 1RX7A 2ANQA 3IRMA 1CD2A 3GHWA 1DDSA 1RX2A 3M09A 2GD9A 4M2XA 3QFXA 4ECKA 3HJ3A 4KL9A 1DR1A 3NTZA 3M08A 3DL6A 4QLGA 3JW5A 4DPDA 3JWCA 2D0KA 1LY4A 3IX9A 2ITHA 3NXYA 1U71A 1DF7A 3GHVA 5HSRA 4PTJA 1DR7A 3QLSA 1PDBA 1RB2A 6DFRA 4H96A 3GI2A 3K47A 1DR5A 3GYFA 3SAIA 1DG8A 4FGGA 3S7AA 2B3ZA 4EIGA 5EAJA 4I1NA 4QJZD 1VJ3A 3IROA 4XECX 1DR4A 4G3MA 4QI9A 1DRBA 3NZDA 4ELEA 1RA8A 4Q67A 4QJCA 3CL9A 1DHIA 4KJKA 3F8YA 2W3WA 1IA2A 1RX9A 3TQ8A 3FQZA 3FQVA 3FQ0A 2JYBA 4KLXA 3FRAX 4OSGA 4XT4A 4PTHA 3JVXA 3DGAA 4KY4A 3QL3A 3FYWX 1RA9A 3F8ZA 4KM2A 3K74A 5HVEA 2L28A 3K45A 1CZ3A 4G8ZX 5U26A 1DAJA 4XT8A 3NZCX 3ZPGA 3NZAX 1RX8A 3NXVA 1DR3A 4QLEA 1DYJA 1RX1A 4LAHX 1J3JA 1RH3A 1DIUA 3EEJA 1AI9A 4HA7A 3I3RA 4X5FA 5DFRA 1JOMA 3FY8X 1RG7A 1RX3A 2D5NA 5ECCA 5HQZA 3L3RA 1KMSA 3DRCA 3I8AX 1J3KA 2DRCA 5DXVA 4Q0DA 1MVTA 3NZBX 3OAFA 1RA3A 8DFRA 1RX4A 3N0HA 2FZIA 5HSUA 3JSUA 4KBNA 4DFRA 4EJ1A 1PD9A 3DL5A 1DG7A 1LY3A 3NXRA 3SRQX 3SRWX 1HFPA 1DG5A 4PSTA 4KJLA 4H97A 1OHJA 3EEKA 3EEMA 3NZ9X 1JUVA 1S3WA 4DP3A 2XW7A 1VDRA 4OR7A 4LEKX 1DLSA 3QYOA 2BLAA 3SRRX 2DHFA 1TDRA 5HUIA 1D1GA 3D84X 2HQPA 1YHOA 3NZ6X 4NX6A 1S3YA 3EELA 1RX6A 4TU5X 2W3AA 3TQ9A 1S3VA 4DDRA 3SRSX 1J3IA 3F0UX 3IA4A 3LG4A 2G6VA 4HOFA 1U72A 3JW3A 1DREA 3VCOA 3EIGA 2W3MA 1DRFA 3UM8A 4M7UA
chains in the Genus database with same CATH topology
3NRRA 3UM5A 5HF2X 2W9TA 4IXGX 1RC4A 3SGYA 1IA3A 3F0SX 1QZFA 5HQYA 1DRAA 3FRDX 2AZNA 2ANOA 3RO9A 3F0QX 4X5GA 5E8QA 3ROAA 1DISA 5HPBA 1M7AA 3CSEA 3QLWA 1HFQA 1KMVA 1DLRA 5CCCA 2FZHA 3QGTA 5HT5A 4M7VA 4KY8A 3FRBX 4ELGA 3EX8A 3FQFA 1JOLA 4Q6AA 3NXXA 4EILA 4M6LA 3E0BA 5HVBA 4X5JA 3NXTA 2QK8A 4EIZA 3F0VX 3FY9X 4ELHA 2INQA 5JG0X 2P4GA 3F91A 4KD7A 2H2QA 3INVA 3DFRA 5ECXA 1DHFA 4Q0EA 1DRHA 1BZFA 1RX5A 3S9UA 3SR5X 1S3UA 3FL8A 4XRBA 3SA1A 2W9GA 3QLYA 3SA2A 2W9HA 3ZPCA 4H95A 3DAUA 1DHJA 4LAEX 1RA2A 3NU0A 1DR2A 4KFJA 3FYVX 3QYLA 3QLXA 2CIGA 4RGCA 4KM0A 4FGHA 4P66A 4GH8A 4HOGA 2OBCA 4G95A 5HT4A 3FREX 4XT5A 4HA9A 2BL9A 1SEJA 2BLBA 3TQAA 2ZZAA 4ELBA 3RG9A 1LUDA 1AOEA 1BOZA 3FS6A 3D80A 1DYHA 1RF7A 1U70A 3F0BX 4IXFX 3K2HA 4LAGX 3KJRA 4M6KA 1M78A 1DYRA 4IXED 3CLBA 3Q1HA 1RA1A 3SH2A 3FRFX 2FZJA 4QHVA 2CD2A 3KY8A 1ZDRA 1M79A 3TQBA 4ELFA 1RD7A 4QLFA 1DR6A 4PSYA 1DDRA 3UM6A 4CD2A 3R33A 2HM9A 4PDJA 3F0XX 5JA3A 3NXOA 1IA1A 1RE7A 3S3VA 4XE6X 4KYAA 2KGKA 3KJSA 3SQYX 3TD8A 1PD8A 1DYIA 1MVSA 3JTWA 3KFYA 4I13A 1IA4A 2O7PA 2HXVA 4KNEA 2W3BA 3FQCA 4XT7A 4HOEA 3FQOA 4KAKA 2LF1A 3DATA 3JWKA 3OCHA 4KEBA 3SRUX 3FL9A 3JWMA 4NX7A 3JWFA 5HI6A 3IA5A 4X5HA 5CC9A 4PSSA 1HFRA 2W3VA 1KLKA 3QLRA 2BLCA 2C2SA 4X5IA 3QG2A 5U27A 4XT6A 3KGYA 2OIPA 3QL0A 2C2TA 1OHKA 4M6JA 3GHCA 3CD2A 4P68A 5FDAA 2W9SA 5HF0X 4H98A 4KJJA 4FHBA 3HBBA 3QLZA 1AO8A 4P3RA 4DPHA 1E26A 3IRNA 7DFRA 1RB3A 3DG8A 4P3QA 1RX7A 2ANQA 3IRMA 1CD2A 3GHWA 1DDSA 1RX2A 3M09A 2GD9A 4M2XA 3QFXA 4ECKA 3HJ3A 4KL9A 1DR1A 3NTZA 3M08A 3DL6A 4QLGA 3JW5A 4DPDA 3JWCA 2D0KA 1LY4A 3IX9A 2ITHA 3NXYA 1U71A 1DF7A 3GHVA 5HSRA 4PTJA 1DR7A 3QLSA 1PDBA 1RB2A 6DFRA 4H96A 3GI2A 3K47A 1DR5A 3GYFA 3SAIA 1DG8A 4FGGA 3S7AA 2B3ZA 4EIGA 5EAJA 4I1NA 4QJZD 1VJ3A 3IROA 4XECX 1DR4A 4G3MA 4QI9A 1DRBA 3NZDA 4ELEA 1RA8A 4Q67A 4QJCA 3CL9A 1DHIA 4KJKA 3F8YA 2W3WA 1IA2A 1RX9A 3TQ8A 3FQZA 3FQVA 3FQ0A 2JYBA 4KLXA 3FRAX 4OSGA 4XT4A 4PTHA 3JVXA 3DGAA 4KY4A 3QL3A 3FYWX 1RA9A 3F8ZA 4KM2A 3K74A 5HVEA 2L28A 3K45A 1CZ3A 4G8ZX 5U26A 1DAJA 4XT8A 3NZCX 3ZPGA 3NZAX 1RX8A 3NXVA 1DR3A 4QLEA 1DYJA 1RX1A 4LAHX 1J3JA 1RH3A 1DIUA 3EEJA 1AI9A 4HA7A 3I3RA 4X5FA 5DFRA 1JOMA 3FY8X 1RG7A 1RX3A 2D5NA 5ECCA 5HQZA 3L3RA 1KMSA 3DRCA 3I8AX 1J3KA 2DRCA 5DXVA 4Q0DA 1MVTA 3NZBX 3OAFA 1RA3A 8DFRA 1RX4A 3N0HA 2FZIA 5HSUA 3JSUA 4KBNA 4DFRA 4EJ1A 1PD9A 3DL5A 1DG7A 1LY3A 3NXRA 3SRQX 3SRWX 1HFPA 1DG5A 4PSTA 4KJLA 4H97A 1OHJA 3EEKA 3EEMA 3NZ9X 1JUVA 1S3WA 4DP3A 2XW7A 1VDRA 4OR7A 4LEKX 1DLSA 3QYOA 2BLAA 3SRRX 2DHFA 1TDRA 5HUIA 1D1GA 3D84X 2HQPA 1YHOA 3NZ6X 4NX6A 1S3YA 3EELA 1RX6A 4TU5X 2W3AA 3TQ9A 1S3VA 4DDRA 3SRSX 1J3IA 3F0UX 3IA4A 3LG4A 2G6VA 4HOFA 1U72A 3JW3A 1DREA 3VCOA 3EIGA 2W3MA 1DRFA 3UM8A 4M7UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NRR A;  3UM5 A;  5HF2 X;  2W9T A;  4IXG X;  1RC4 A;  3SGY A;  1IA3 A;  3F0S X;  1QZF A;  5HQY A;  1DRA A;  3FRD X;  2AZN A;  2ANO A;  3RO9 A;  3F0Q X;  4X5G A;  5E8Q A;  3ROA A;  1DIS A;  5HPB A;  1M7A A;  3CSE A;  3QLW A;  1HFQ A;  1KMV A;  1DLR A;  5CCC A;  2FZH A;  3QGT A;  5HT5 A;  4M7V A;  4KY8 A;  3FRB X;  4ELG A;  3EX8 A;  3FQF A;  1JOL A;  4Q6A A;  3NXX A;  4EIL A;  4M6L A;  3E0B A;  5HVB A;  4X5J A;  3NXT A;  2QK8 A;  4EIZ A;  3F0V X;  3FY9 X;  4ELH A;  2INQ A;  5JG0 X;  2P4G A;  3F91 A;  4KD7 A;  2H2Q A;  3INV A;  3DFR A;  5ECX A;  1DHF A;  4Q0E A;  1DRH A;  1BZF A;  1RX5 A;  3S9U A;  3SR5 X;  1S3U A;  3FL8 A;  4XRB A;  3SA1 A;  2W9G A;  3QLY A;  3SA2 A;  2W9H A;  3ZPC A;  4H95 A;  3DAU A;  1DHJ A;  4LAE X;  1RA2 A;  3NU0 A;  1DR2 A;  4KFJ A;  3FYV X;  3QYL A;  3QLX A;  2CIG A;  4RGC A;  4KM0 A;  4FGH A;  4P66 A;  4GH8 A;  4HOG A;  2OBC A;  4G95 A;  5HT4 A;  3FRE X;  4XT5 A;  4HA9 A;  2BL9 A;  1SEJ A;  2BLB A;  3TQA A;  2ZZA A;  4ELB A;  3RG9 A;  1LUD A;  1AOE A;  1BOZ A;  3FS6 A;  3D80 A;  1DYH A;  1RF7 A;  1U70 A;  3F0B X;  4IXF X;  3K2H A;  4LAG X;  3KJR A;  4M6K A;  1M78 A;  1DYR A;  4IXE D;  3CLB A;  3Q1H A;  1RA1 A;  3SH2 A;  3FRF X;  2FZJ A;  4QHV A;  2CD2 A;  3KY8 A;  1ZDR A;  1M79 A;  3TQB A;  4ELF A;  1RD7 A;  4QLF A;  1DR6 A;  4PSY A;  1DDR A;  3UM6 A;  4CD2 A;  3R33 A;  2HM9 A;  4PDJ A;  3F0X X;  5JA3 A;  3NXO A;  1IA1 A;  1RE7 A;  3S3V A;  4XE6 X;  4KYA A;  2KGK A;  3KJS A;  3SQY X;  3TD8 A;  1PD8 A;  1DYI A;  1MVS A;  3JTW A;  3KFY A;  4I13 A;  1IA4 A;  2O7P A;  2HXV A;  4KNE A;  2W3B A;  3FQC A;  4XT7 A;  4HOE A;  3FQO A;  4KAK A;  2LF1 A;  3DAT A;  3JWK A;  3OCH A;  4KEB A;  3SRU X;  3FL9 A;  3JWM A;  4NX7 A;  3JWF A;  5HI6 A;  3IA5 A;  4X5H A;  5CC9 A;  4PSS A;  1HFR A;  2W3V A;  1KLK A;  3QLR A;  2BLC A;  2C2S A;  4X5I A;  3QG2 A;  5U27 A;  4XT6 A;  3KGY A;  2OIP A;  3QL0 A;  2C2T A;  1OHK A;  4M6J A;  3GHC A;  3CD2 A;  4P68 A;  5FDA A;  2W9S A;  5HF0 X;  4H98 A;  4KJJ A;  4FHB A;  3HBB A;  3QLZ A;  1AO8 A;  4P3R A;  4DPH A;  1E26 A;  3IRN A;  7DFR A;  1RB3 A;  3DG8 A;  4P3Q A;  1RX7 A;  2ANQ A;  3IRM A;  1CD2 A;  3GHW A;  1DDS A;  1RX2 A;  3M09 A;  2GD9 A;  4M2X A;  3QFX A;  4ECK A;  3HJ3 A;  4KL9 A;  1DR1 A;  3NTZ A;  3M08 A;  3DL6 A;  4QLG A;  3JW5 A;  4DPD A;  3JWC A;  2D0K A;  1LY4 A;  3IX9 A;  2ITH A;  3NXY A;  1U71 A;  1DF7 A;  3GHV A;  5HSR A;  4PTJ A;  1DR7 A;  3QLS A;  1PDB A;  1RB2 A;  6DFR A;  4H96 A;  3GI2 A;  3K47 A;  1DR5 A;  3GYF A;  3SAI A;  1DG8 A;  4FGG A;  3S7A A;  2B3Z A;  4EIG A;  5EAJ A;  4I1N A;  4QJZ D;  1VJ3 A;  3IRO A;  4XEC X;  1DR4 A;  4G3M A;  4QI9 A;  1DRB A;  3NZD A;  4ELE A;  1RA8 A;  4Q67 A;  4QJC A;  3CL9 A;  1DHI A;  4KJK A;  3F8Y A;  2W3W A;  1IA2 A;  1RX9 A;  3TQ8 A;  3FQZ A;  3FQV A;  3FQ0 A;  2JYB A;  4KLX A;  3FRA X;  4OSG A;  4XT4 A;  4PTH A;  3JVX A;  3DGA A;  4KY4 A;  3QL3 A;  3FYW X;  1RA9 A;  3F8Z A;  4KM2 A;  3K74 A;  5HVE A;  2L28 A;  3K45 A;  1CZ3 A;  4G8Z X;  5U26 A;  1DAJ A;  4XT8 A;  3NZC X;  3ZPG A;  3NZA X;  1RX8 A;  3NXV A;  1DR3 A;  4QLE A;  1DYJ A;  1RX1 A;  4LAH X;  1J3J A;  1RH3 A;  1DIU A;  3EEJ A;  1AI9 A;  4HA7 A;  3I3R A;  4X5F A;  5DFR A;  1JOM A;  3FY8 X;  1RG7 A;  1RX3 A;  2D5N A;  5ECC A;  5HQZ A;  3L3R A;  1KMS A;  3DRC A;  3I8A X;  1J3K A;  2DRC A;  5DXV A;  4Q0D A;  1MVT A;  3NZB X;  3OAF A;  1RA3 A;  8DFR A;  1RX4 A;  3N0H A;  2FZI A;  5HSU A;  3JSU A;  4KBN A;  4DFR A;  4EJ1 A;  1PD9 A;  3DL5 A;  1DG7 A;  1LY3 A;  3NXR A;  3SRQ X;  3SRW X;  1HFP A;  1DG5 A;  4PST A;  4KJL A;  4H97 A;  1OHJ A;  3EEK A;  3EEM A;  3NZ9 X;  1JUV A;  1S3W A;  4DP3 A;  2XW7 A;  1VDR A;  4OR7 A;  4LEK X;  1DLS A;  3QYO A;  2BLA A;  3SRR X;  2DHF A;  1TDR A;  5HUI A;  1D1G A;  3D84 X;  2HQP A;  1YHO A;  3NZ6 X;  4NX6 A;  1S3Y A;  3EEL A;  1RX6 A;  4TU5 X;  2W3A A;  3TQ9 A;  1S3V A;  4DDR A;  3SRS X;  1J3I A;  3F0U X;  3IA4 A;  3LG4 A;  2G6V A;  4HOF A;  1U72 A;  3JW3 A;  1DRE A;  3VCO A;  3EIG A;  2W3M A;  1DRF A;  3UM8 A;  4M7U A; 
#chains in the Genus database with same CATH topology
 3NRR A;  3UM5 A;  5HF2 X;  2W9T A;  4IXG X;  1RC4 A;  3SGY A;  1IA3 A;  3F0S X;  1QZF A;  5HQY A;  1DRA A;  3FRD X;  2AZN A;  2ANO A;  3RO9 A;  3F0Q X;  4X5G A;  5E8Q A;  3ROA A;  1DIS A;  5HPB A;  1M7A A;  3CSE A;  3QLW A;  1HFQ A;  1KMV A;  1DLR A;  5CCC A;  2FZH A;  3QGT A;  5HT5 A;  4M7V A;  4KY8 A;  3FRB X;  4ELG A;  3EX8 A;  3FQF A;  1JOL A;  4Q6A A;  3NXX A;  4EIL A;  4M6L A;  3E0B A;  5HVB A;  4X5J A;  3NXT A;  2QK8 A;  4EIZ A;  3F0V X;  3FY9 X;  4ELH A;  2INQ A;  5JG0 X;  2P4G A;  3F91 A;  4KD7 A;  2H2Q A;  3INV A;  3DFR A;  5ECX A;  1DHF A;  4Q0E A;  1DRH A;  1BZF A;  1RX5 A;  3S9U A;  3SR5 X;  1S3U A;  3FL8 A;  4XRB A;  3SA1 A;  2W9G A;  3QLY A;  3SA2 A;  2W9H A;  3ZPC A;  4H95 A;  3DAU A;  1DHJ A;  4LAE X;  1RA2 A;  3NU0 A;  1DR2 A;  4KFJ A;  3FYV X;  3QYL A;  3QLX A;  2CIG A;  4RGC A;  4KM0 A;  4FGH A;  4P66 A;  4GH8 A;  4HOG A;  2OBC A;  4G95 A;  5HT4 A;  3FRE X;  4XT5 A;  4HA9 A;  2BL9 A;  1SEJ A;  2BLB A;  3TQA A;  2ZZA A;  4ELB A;  3RG9 A;  1LUD A;  1AOE A;  1BOZ A;  3FS6 A;  3D80 A;  1DYH A;  1RF7 A;  1U70 A;  3F0B X;  4IXF X;  3K2H A;  4LAG X;  3KJR A;  4M6K A;  1M78 A;  1DYR A;  4IXE D;  3CLB A;  3Q1H A;  1RA1 A;  3SH2 A;  3FRF X;  2FZJ A;  4QHV A;  2CD2 A;  3KY8 A;  1ZDR A;  1M79 A;  3TQB A;  4ELF A;  1RD7 A;  4QLF A;  1DR6 A;  4PSY A;  1DDR A;  3UM6 A;  4CD2 A;  3R33 A;  2HM9 A;  4PDJ A;  3F0X X;  5JA3 A;  3NXO A;  1IA1 A;  1RE7 A;  3S3V A;  4XE6 X;  4KYA A;  2KGK A;  3KJS A;  3SQY X;  3TD8 A;  1PD8 A;  1DYI A;  1MVS A;  3JTW A;  3KFY A;  4I13 A;  1IA4 A;  2O7P A;  2HXV A;  4KNE A;  2W3B A;  3FQC A;  4XT7 A;  4HOE A;  3FQO A;  4KAK A;  2LF1 A;  3DAT A;  3JWK A;  3OCH A;  4KEB A;  3SRU X;  3FL9 A;  3JWM A;  4NX7 A;  3JWF A;  5HI6 A;  3IA5 A;  4X5H A;  5CC9 A;  4PSS A;  1HFR A;  2W3V A;  1KLK A;  3QLR A;  2BLC A;  2C2S A;  4X5I A;  3QG2 A;  5U27 A;  4XT6 A;  3KGY A;  2OIP A;  3QL0 A;  2C2T A;  1OHK A;  4M6J A;  3GHC A;  3CD2 A;  4P68 A;  5FDA A;  2W9S A;  5HF0 X;  4H98 A;  4KJJ A;  4FHB A;  3HBB A;  3QLZ A;  1AO8 A;  4P3R A;  4DPH A;  1E26 A;  3IRN A;  7DFR A;  1RB3 A;  3DG8 A;  4P3Q A;  1RX7 A;  2ANQ A;  3IRM A;  1CD2 A;  3GHW A;  1DDS A;  1RX2 A;  3M09 A;  2GD9 A;  4M2X A;  3QFX A;  4ECK A;  3HJ3 A;  4KL9 A;  1DR1 A;  3NTZ A;  3M08 A;  3DL6 A;  4QLG A;  3JW5 A;  4DPD A;  3JWC A;  2D0K A;  1LY4 A;  3IX9 A;  2ITH A;  3NXY A;  1U71 A;  1DF7 A;  3GHV A;  5HSR A;  4PTJ A;  1DR7 A;  3QLS A;  1PDB A;  1RB2 A;  6DFR A;  4H96 A;  3GI2 A;  3K47 A;  1DR5 A;  3GYF A;  3SAI A;  1DG8 A;  4FGG A;  3S7A A;  2B3Z A;  4EIG A;  5EAJ A;  4I1N A;  4QJZ D;  1VJ3 A;  3IRO A;  4XEC X;  1DR4 A;  4G3M A;  4QI9 A;  1DRB A;  3NZD A;  4ELE A;  1RA8 A;  4Q67 A;  4QJC A;  3CL9 A;  1DHI A;  4KJK A;  3F8Y A;  2W3W A;  1IA2 A;  1RX9 A;  3TQ8 A;  3FQZ A;  3FQV A;  3FQ0 A;  2JYB A;  4KLX A;  3FRA X;  4OSG A;  4XT4 A;  4PTH A;  3JVX A;  3DGA A;  4KY4 A;  3QL3 A;  3FYW X;  1RA9 A;  3F8Z A;  4KM2 A;  3K74 A;  5HVE A;  2L28 A;  3K45 A;  1CZ3 A;  4G8Z X;  5U26 A;  1DAJ A;  4XT8 A;  3NZC X;  3ZPG A;  3NZA X;  1RX8 A;  3NXV A;  1DR3 A;  4QLE A;  1DYJ A;  1RX1 A;  4LAH X;  1J3J A;  1RH3 A;  1DIU A;  3EEJ A;  1AI9 A;  4HA7 A;  3I3R A;  4X5F A;  5DFR A;  1JOM A;  3FY8 X;  1RG7 A;  1RX3 A;  2D5N A;  5ECC A;  5HQZ A;  3L3R A;  1KMS A;  3DRC A;  3I8A X;  1J3K A;  2DRC A;  5DXV A;  4Q0D A;  1MVT A;  3NZB X;  3OAF A;  1RA3 A;  8DFR A;  1RX4 A;  3N0H A;  2FZI A;  5HSU A;  3JSU A;  4KBN A;  4DFR A;  4EJ1 A;  1PD9 A;  3DL5 A;  1DG7 A;  1LY3 A;  3NXR A;  3SRQ X;  3SRW X;  1HFP A;  1DG5 A;  4PST A;  4KJL A;  4H97 A;  1OHJ A;  3EEK A;  3EEM A;  3NZ9 X;  1JUV A;  1S3W A;  4DP3 A;  2XW7 A;  1VDR A;  4OR7 A;  4LEK X;  1DLS A;  3QYO A;  2BLA A;  3SRR X;  2DHF A;  1TDR A;  5HUI A;  1D1G A;  3D84 X;  2HQP A;  1YHO A;  3NZ6 X;  4NX6 A;  1S3Y A;  3EEL A;  1RX6 A;  4TU5 X;  2W3A A;  3TQ9 A;  1S3V A;  4DDR A;  3SRS X;  1J3I A;  3F0U X;  3IA4 A;  3LG4 A;  2G6V A;  4HOF A;  1U72 A;  3JW3 A;  1DRE A;  3VCO A;  3EIG A;  2W3M A;  1DRF A;  3UM8 A;  4M7U A; 
#chains in the Genus database with same CATH homology
 3NRR A;  3UM5 A;  5HF2 X;  2W9T A;  4IXG X;  1RC4 A;  3SGY A;  1IA3 A;  3F0S X;  1QZF A;  5HQY A;  1DRA A;  3FRD X;  2AZN A;  2ANO A;  3RO9 A;  3F0Q X;  4X5G A;  5E8Q A;  3ROA A;  1DIS A;  5HPB A;  1M7A A;  3CSE A;  3QLW A;  1HFQ A;  1KMV A;  1DLR A;  5CCC A;  2FZH A;  3QGT A;  5HT5 A;  4M7V A;  4KY8 A;  3FRB X;  4ELG A;  3EX8 A;  3FQF A;  1JOL A;  4Q6A A;  3NXX A;  4EIL A;  4M6L A;  3E0B A;  5HVB A;  4X5J A;  3NXT A;  2QK8 A;  4EIZ A;  3F0V X;  3FY9 X;  4ELH A;  2INQ A;  5JG0 X;  2P4G A;  3F91 A;  4KD7 A;  2H2Q A;  3INV A;  3DFR A;  5ECX A;  1DHF A;  4Q0E A;  1DRH A;  1BZF A;  1RX5 A;  3S9U A;  3SR5 X;  1S3U A;  3FL8 A;  4XRB A;  3SA1 A;  2W9G A;  3QLY A;  3SA2 A;  2W9H A;  3ZPC A;  4H95 A;  3DAU A;  1DHJ A;  4LAE X;  1RA2 A;  3NU0 A;  1DR2 A;  4KFJ A;  3FYV X;  3QYL A;  3QLX A;  2CIG A;  4RGC A;  4KM0 A;  4FGH A;  4P66 A;  4GH8 A;  4HOG A;  2OBC A;  4G95 A;  5HT4 A;  3FRE X;  4XT5 A;  4HA9 A;  2BL9 A;  1SEJ A;  2BLB A;  3TQA A;  2ZZA A;  4ELB A;  3RG9 A;  1LUD A;  1AOE A;  1BOZ A;  3FS6 A;  3D80 A;  1DYH A;  1RF7 A;  1U70 A;  3F0B X;  4IXF X;  3K2H A;  4LAG X;  3KJR A;  4M6K A;  1M78 A;  1DYR A;  4IXE D;  3CLB A;  3Q1H A;  1RA1 A;  3SH2 A;  3FRF X;  2FZJ A;  4QHV A;  2CD2 A;  3KY8 A;  1ZDR A;  1M79 A;  3TQB A;  4ELF A;  1RD7 A;  4QLF A;  1DR6 A;  4PSY A;  1DDR A;  3UM6 A;  4CD2 A;  3R33 A;  2HM9 A;  4PDJ A;  3F0X X;  5JA3 A;  3NXO A;  1IA1 A;  1RE7 A;  3S3V A;  4XE6 X;  4KYA A;  2KGK A;  3KJS A;  3SQY X;  3TD8 A;  1PD8 A;  1DYI A;  1MVS A;  3JTW A;  3KFY A;  4I13 A;  1IA4 A;  2O7P A;  2HXV A;  4KNE A;  2W3B A;  3FQC A;  4XT7 A;  4HOE A;  3FQO A;  4KAK A;  2LF1 A;  3DAT A;  3JWK A;  3OCH A;  4KEB A;  3SRU X;  3FL9 A;  3JWM A;  4NX7 A;  3JWF A;  5HI6 A;  3IA5 A;  4X5H A;  5CC9 A;  4PSS A;  1HFR A;  2W3V A;  1KLK A;  3QLR A;  2BLC A;  2C2S A;  4X5I A;  3QG2 A;  5U27 A;  4XT6 A;  3KGY A;  2OIP A;  3QL0 A;  2C2T A;  1OHK A;  4M6J A;  3GHC A;  3CD2 A;  4P68 A;  5FDA A;  2W9S A;  5HF0 X;  4H98 A;  4KJJ A;  4FHB A;  3HBB A;  3QLZ A;  1AO8 A;  4P3R A;  4DPH A;  1E26 A;  3IRN A;  7DFR A;  1RB3 A;  3DG8 A;  4P3Q A;  1RX7 A;  2ANQ A;  3IRM A;  1CD2 A;  3GHW A;  1DDS A;  1RX2 A;  3M09 A;  2GD9 A;  4M2X A;  3QFX A;  4ECK A;  3HJ3 A;  4KL9 A;  1DR1 A;  3NTZ A;  3M08 A;  3DL6 A;  4QLG A;  3JW5 A;  4DPD A;  3JWC A;  2D0K A;  1LY4 A;  3IX9 A;  2ITH A;  3NXY A;  1U71 A;  1DF7 A;  3GHV A;  5HSR A;  4PTJ A;  1DR7 A;  3QLS A;  1PDB A;  1RB2 A;  6DFR A;  4H96 A;  3GI2 A;  3K47 A;  1DR5 A;  3GYF A;  3SAI A;  1DG8 A;  4FGG A;  3S7A A;  2B3Z A;  4EIG A;  5EAJ A;  4I1N A;  4QJZ D;  1VJ3 A;  3IRO A;  4XEC X;  1DR4 A;  4G3M A;  4QI9 A;  1DRB A;  3NZD A;  4ELE A;  1RA8 A;  4Q67 A;  4QJC A;  3CL9 A;  1DHI A;  4KJK A;  3F8Y A;  2W3W A;  1IA2 A;  1RX9 A;  3TQ8 A;  3FQZ A;  3FQV A;  3FQ0 A;  2JYB A;  4KLX A;  3FRA X;  4OSG A;  4XT4 A;  4PTH A;  3JVX A;  3DGA A;  4KY4 A;  3QL3 A;  3FYW X;  1RA9 A;  3F8Z A;  4KM2 A;  3K74 A;  5HVE A;  2L28 A;  3K45 A;  1CZ3 A;  4G8Z X;  5U26 A;  1DAJ A;  4XT8 A;  3NZC X;  3ZPG A;  3NZA X;  1RX8 A;  3NXV A;  1DR3 A;  4QLE A;  1DYJ A;  1RX1 A;  4LAH X;  1J3J A;  1RH3 A;  1DIU A;  3EEJ A;  1AI9 A;  4HA7 A;  3I3R A;  4X5F A;  5DFR A;  1JOM A;  3FY8 X;  1RG7 A;  1RX3 A;  2D5N A;  5ECC A;  5HQZ A;  3L3R A;  1KMS A;  3DRC A;  3I8A X;  1J3K A;  2DRC A;  5DXV A;  4Q0D A;  1MVT A;  3NZB X;  3OAF A;  1RA3 A;  8DFR A;  1RX4 A;  3N0H A;  2FZI A;  5HSU A;  3JSU A;  4KBN A;  4DFR A;  4EJ1 A;  1PD9 A;  3DL5 A;  1DG7 A;  1LY3 A;  3NXR A;  3SRQ X;  3SRW X;  1HFP A;  1DG5 A;  4PST A;  4KJL A;  4H97 A;  1OHJ A;  3EEK A;  3EEM A;  3NZ9 X;  1JUV A;  1S3W A;  4DP3 A;  2XW7 A;  1VDR A;  4OR7 A;  4LEK X;  1DLS A;  3QYO A;  2BLA A;  3SRR X;  2DHF A;  1TDR A;  5HUI A;  1D1G A;  3D84 X;  2HQP A;  1YHO A;  3NZ6 X;  4NX6 A;  1S3Y A;  3EEL A;  1RX6 A;  4TU5 X;  2W3A A;  3TQ9 A;  1S3V A;  4DDR A;  3SRS X;  1J3I A;  3F0U X;  3IA4 A;  3LG4 A;  2G6V A;  4HOF A;  1U72 A;  3JW3 A;  1DRE A;  3VCO A;  3EIG A;  2W3M A;  1DRF A;  3UM8 A;  4M7U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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