2W3AA

Human dihydrofolate reductase complexed with nadph and trimethoprim
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate
rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 48
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2008-11-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 2w3aA00
1DHJA 1RG7A 2DHFA 4X5HA 1RA1A 3F0BX 3JWKA 3M08A 5FDAA 1TDRA 3F0VX 4KM2A 1J3JA 1RA3A 3F0XX 4DFRA 3F0UX 3QL3A 1AI9A 3DG8A 4FHBA 1KMSA 3FRFX 3SRQX 1U72A 3NZCX 1RX8A 3K47A 2DRCA 3JWMA 3SRSX 5U27A 1BZFA 3EX8A 3NXTA 3KJRA 3FRDX 3UM8A 1DYJA 1RX3A 3FRBX 4PSSA 2JYBA 3SH2A 1RE7A 4DPDA 4P66A 3NRRA 3JW5A 1CZ3A 1IA2A 3Q1HA 4PTHA 3NU0A 3FRAX 4P3RA 1DRHA 4ELFA 1DR6A 5HPBA 3QFXA 4LEKX 1IA4A 5JG0X 3N0HA 3FQOA 3CLBA 3FY8X 2BLCA 1OHKA 3SGYA 3FL9A 1M79A 2AZNA 4KBNA 3TQBA 1DG7A 4KJJA 1DDSA 4OR7A 4LAHX 3NXVA 1DRAA 2HM9A 3F91A 5DFRA 1DHFA 3INVA 1RX1A 3QGTA 3OAFA 3OCHA 2BLAA 1DYHA 4H95A 4FGHA 4OSGA 4QLGA 4KEBA 4M6KA 4X5FA 4XT7A 4EJ1A 3M09A 2ITHA 2W9TA 2P4GA 4H98A 1J3IA 3JVXA 1DIUA 3DRCA 4QI9A 3QG2A 3CL9A 5ECCA 4QJZD 3FQCA 3F8ZA 2C2SA 5DXVA 8DFRA 3EIGA 4Q0DA 4LAGX 1RX5A 2ANQA 3UM6A 4CD2A 1KMVA 3FREX 1RB3A 3SRWX 1D1GA 1DG5A 4IXED 3GHCA 3JSUA 1M7AA 1MVSA 5EAJA 1RF7A 2ZZAA 3JW3A 1QZFA 1S3YA 3NZBX 4KJKA 4KNEA 2CD2A 3QLXA 3QL0A 1DYIA 4DDRA 3TQ8A 3DATA 4QJCA 4XT8A 2KGKA 4IXGX 3EELA 4RGCA 4HOFA 3F0QX 1RA9A 1DRBA 4XT4A 5HVBA 3IRMA 2OBCA 4TU5X 1LUDA 3DL6A 3UM5A 4QHVA 3NZAX 3NXOA 2H2QA 3JTWA 3NXYA 2C2TA 4PTJA 1S3VA 3SQYX 5HQYA 3NZ6X 4IXFX 1ZDRA 4EILA 1CD2A 1DLRA 4XECX 3K45A 2QK8A 4ELEA 4QLFA 1HFQA 4H96A 4M7VA 3FS6A 1DDRA 3DL5A 4KLXA 1DISA 5E8QA 3DFRA 2FZIA 1DR3A 3SAIA 4QLEA 5HT5A 6DFRA 3KJSA 4PDJA 1RX6A 5HUIA 2W9SA 4M2XA 4GH8A 5JA3A 2FZHA 2ANOA 4M7UA 4I13A 3IROA 3LG4A 2W3WA 4KL9A 3FQFA 3FY9X 3GYFA 1S3UA 3K2HA 1RX2A 4Q67A 1AOEA 4LAEX 3QLSA 3TD8A 4XE6X 3FYVX 3S3VA 4X5GA 4KY4A 3ROAA 2BLBA 3F8YA 3IRNA 4Q6AA 4X5JA 1DR2A 1KLKA 4EIZA 1MVTA 2HXVA 3DGAA 4XRBA 1DRFA 1LY3A 2CIGA 4KYAA 2XW7A 5HF2X 3KGYA 1JUVA 1HFRA 2BL9A 2W3AA 3JWFA 4G95A 4XT6A 3NZ9X 1U70A 3SRUX 3QYOA 1PD9A 1AO8A 3SRRX 5HSRA 3CSEA 1DR7A 4M6LA 1RX4A 3CD2A 3FL8A 3S7AA 4KM0A 3EEJA 4KFJA 1DR4A 3SR5X 1SEJA 3E0BA 1S3WA 1VDRA 4PSYA 3I8AX 3TQ9A 3I3RA 4Q0EA 3NXRA 3QLWA 4NX7A 3NTZA 4H97A 5HSUA 4HOGA 3GHVA 2B3ZA 3IA4A 2G6VA 4NX6A 4XT5A 3D80A 3QLRA 1U71A 4I1NA 1PD8A 5HVEA 2HQPA 4PSTA 1JOLA 2OIPA 4DPHA 4X5IA 3FQ0A 4G8ZX 1DAJA 4KAKA 3FQZA 1DF7A 1RA8A 4EIGA 3KFYA 4HA9A 3ZPGA 1RX7A 4DP3A 5HT4A 1RB2A 1JOMA 3K74A 1BOZA 4P3QA 1DR1A 4P68A 2W3MA 2D0KA 1YHOA 1DG8A 3QLYA 5ECXA 1IA1A 1VJ3A 1LY4A 3HBBA 1RX9A 5HI6A 5HQZA 5CC9A 2D5NA 4G3MA 4ELGA 7DFRA 3IX9A 5HF0X 4M6JA 3R33A 1DHIA 5U26A 4ELBA 4ELHA 2GD9A 3QLZA 2W3BA 1IA3A 1E26A 3ZPCA 3SA1A 3FYWX 3NXXA 1RA2A 2W3VA 3SA2A 2L28A 3RG9A 3HJ3A 1RD7A 2W9HA 5CCCA 4HA7A 4ECKA 2W9GA 3NZDA 4HOEA 2LF1A 3L3RA 1DREA 4KD7A 1OHJA 3JWCA 3GHWA 4FGGA 1DYRA 3D84X 4KJLA 1J3KA 1DLSA 1RC4A 1PDBA 1M78A 2FZJA 3DAUA 3QYLA 3TQAA 1RH3A 4KY8A 2INQA 3FQVA 3EEMA 3IA5A 1DR5A 3VCOA 3KY8A 1HFPA 3RO9A 2O7PA 3S9UA 3EEKA 3GI2A 3F0SX
chains in the Genus database with same CATH superfamily
1DHJA 1RG7A 2DHFA 4X5HA 1RA1A 3F0BX 3JWKA 3M08A 5FDAA 1TDRA 3F0VX 4KM2A 1J3JA 1RA3A 3F0XX 4DFRA 3F0UX 3QL3A 1AI9A 3DG8A 4FHBA 1KMSA 3FRFX 3SRQX 1U72A 3NZCX 1RX8A 3K47A 2DRCA 3JWMA 3SRSX 5U27A 1BZFA 3EX8A 3NXTA 3KJRA 3FRDX 3UM8A 1DYJA 1RX3A 3FRBX 4PSSA 2JYBA 3SH2A 1RE7A 4DPDA 4P66A 3NRRA 3JW5A 1CZ3A 1IA2A 3Q1HA 4PTHA 3NU0A 3FRAX 4P3RA 1DRHA 4ELFA 1DR6A 5HPBA 3QFXA 4LEKX 1IA4A 5JG0X 3N0HA 3FQOA 3CLBA 3FY8X 2BLCA 1OHKA 3SGYA 3FL9A 1M79A 2AZNA 4KBNA 3TQBA 1DG7A 4KJJA 1DDSA 4OR7A 4LAHX 3NXVA 1DRAA 2HM9A 3F91A 5DFRA 1DHFA 3INVA 1RX1A 3QGTA 3OAFA 3OCHA 2BLAA 1DYHA 4H95A 4FGHA 4OSGA 4QLGA 4KEBA 4M6KA 4X5FA 4XT7A 4EJ1A 3M09A 2ITHA 2W9TA 2P4GA 4H98A 1J3IA 3JVXA 1DIUA 3DRCA 4QI9A 3QG2A 3CL9A 5ECCA 4QJZD 3FQCA 3F8ZA 2C2SA 5DXVA 8DFRA 3EIGA 4Q0DA 4LAGX 1RX5A 2ANQA 3UM6A 4CD2A 1KMVA 3FREX 1RB3A 3SRWX 1D1GA 1DG5A 4IXED 3GHCA 3JSUA 1M7AA 1MVSA 5EAJA 1RF7A 2ZZAA 3JW3A 1QZFA 1S3YA 3NZBX 4KJKA 4KNEA 2CD2A 3QLXA 3QL0A 1DYIA 4DDRA 3TQ8A 3DATA 4QJCA 4XT8A 2KGKA 4IXGX 3EELA 4RGCA 4HOFA 3F0QX 1RA9A 1DRBA 4XT4A 5HVBA 3IRMA 2OBCA 4TU5X 1LUDA 3DL6A 3UM5A 4QHVA 3NZAX 3NXOA 2H2QA 3JTWA 3NXYA 2C2TA 4PTJA 1S3VA 3SQYX 5HQYA 3NZ6X 4IXFX 1ZDRA 4EILA 1CD2A 1DLRA 4XECX 3K45A 2QK8A 4ELEA 4QLFA 1HFQA 4H96A 4M7VA 3FS6A 1DDRA 3DL5A 4KLXA 1DISA 5E8QA 3DFRA 2FZIA 1DR3A 3SAIA 4QLEA 5HT5A 6DFRA 3KJSA 4PDJA 1RX6A 5HUIA 2W9SA 4M2XA 4GH8A 5JA3A 2FZHA 2ANOA 4M7UA 4I13A 3IROA 3LG4A 2W3WA 4KL9A 3FQFA 3FY9X 3GYFA 1S3UA 3K2HA 1RX2A 4Q67A 1AOEA 4LAEX 3QLSA 3TD8A 4XE6X 3FYVX 3S3VA 4X5GA 4KY4A 3ROAA 2BLBA 3F8YA 3IRNA 4Q6AA 4X5JA 1DR2A 1KLKA 4EIZA 1MVTA 2HXVA 3DGAA 4XRBA 1DRFA 1LY3A 2CIGA 4KYAA 2XW7A 5HF2X 3KGYA 1JUVA 1HFRA 2BL9A 2W3AA 3JWFA 4G95A 4XT6A 3NZ9X 1U70A 3SRUX 3QYOA 1PD9A 1AO8A 3SRRX 5HSRA 3CSEA 1DR7A 4M6LA 1RX4A 3CD2A 3FL8A 3S7AA 4KM0A 3EEJA 4KFJA 1DR4A 3SR5X 1SEJA 3E0BA 1S3WA 1VDRA 4PSYA 3I8AX 3TQ9A 3I3RA 4Q0EA 3NXRA 3QLWA 4NX7A 3NTZA 4H97A 5HSUA 4HOGA 3GHVA 2B3ZA 3IA4A 2G6VA 4NX6A 4XT5A 3D80A 3QLRA 1U71A 4I1NA 1PD8A 5HVEA 2HQPA 4PSTA 1JOLA 2OIPA 4DPHA 4X5IA 3FQ0A 4G8ZX 1DAJA 4KAKA 3FQZA 1DF7A 1RA8A 4EIGA 3KFYA 4HA9A 3ZPGA 1RX7A 4DP3A 5HT4A 1RB2A 1JOMA 3K74A 1BOZA 4P3QA 1DR1A 4P68A 2W3MA 2D0KA 1YHOA 1DG8A 3QLYA 5ECXA 1IA1A 1VJ3A 1LY4A 3HBBA 1RX9A 5HI6A 5HQZA 5CC9A 2D5NA 4G3MA 4ELGA 7DFRA 3IX9A 5HF0X 4M6JA 3R33A 1DHIA 5U26A 4ELBA 4ELHA 2GD9A 3QLZA 2W3BA 1IA3A 1E26A 3ZPCA 3SA1A 3FYWX 3NXXA 1RA2A 2W3VA 3SA2A 2L28A 3RG9A 3HJ3A 1RD7A 2W9HA 5CCCA 4HA7A 4ECKA 2W9GA 3NZDA 4HOEA 2LF1A 3L3RA 1DREA 4KD7A 1OHJA 3JWCA 3GHWA 4FGGA 1DYRA 3D84X 4KJLA 1J3KA 1DLSA 1RC4A 1PDBA 1M78A 2FZJA 3DAUA 3QYLA 3TQAA 1RH3A 4KY8A 2INQA 3FQVA 3EEMA 3IA5A 1DR5A 3VCOA 3KY8A 1HFPA 3RO9A 2O7PA 3S9UA 3EEKA 3GI2A 3F0SX
chains in the Genus database with same CATH topology
1DHJA 1RG7A 2DHFA 4X5HA 1RA1A 3F0BX 3JWKA 3M08A 5FDAA 1TDRA 3F0VX 4KM2A 1J3JA 1RA3A 3F0XX 4DFRA 3F0UX 3QL3A 1AI9A 3DG8A 4FHBA 1KMSA 3FRFX 3SRQX 1U72A 3NZCX 1RX8A 3K47A 2DRCA 3JWMA 3SRSX 5U27A 1BZFA 3EX8A 3NXTA 3KJRA 3FRDX 3UM8A 1DYJA 1RX3A 3FRBX 4PSSA 2JYBA 3SH2A 1RE7A 4DPDA 4P66A 3NRRA 3JW5A 1CZ3A 1IA2A 3Q1HA 4PTHA 3NU0A 3FRAX 4P3RA 1DRHA 4ELFA 1DR6A 5HPBA 3QFXA 4LEKX 1IA4A 5JG0X 3N0HA 3FQOA 3CLBA 3FY8X 2BLCA 1OHKA 3SGYA 3FL9A 1M79A 2AZNA 4KBNA 3TQBA 1DG7A 4KJJA 1DDSA 4OR7A 4LAHX 3NXVA 1DRAA 2HM9A 3F91A 5DFRA 1DHFA 3INVA 1RX1A 3QGTA 3OAFA 3OCHA 2BLAA 1DYHA 4H95A 4FGHA 4OSGA 4QLGA 4KEBA 4M6KA 4X5FA 4XT7A 4EJ1A 3M09A 2ITHA 2W9TA 2P4GA 4H98A 1J3IA 3JVXA 1DIUA 3DRCA 4QI9A 3QG2A 3CL9A 5ECCA 4QJZD 3FQCA 3F8ZA 2C2SA 5DXVA 8DFRA 3EIGA 4Q0DA 4LAGX 1RX5A 2ANQA 3UM6A 4CD2A 1KMVA 3FREX 1RB3A 3SRWX 1D1GA 1DG5A 4IXED 3GHCA 3JSUA 1M7AA 1MVSA 5EAJA 1RF7A 2ZZAA 3JW3A 1QZFA 1S3YA 3NZBX 4KJKA 4KNEA 2CD2A 3QLXA 3QL0A 1DYIA 4DDRA 3TQ8A 3DATA 4QJCA 4XT8A 2KGKA 4IXGX 3EELA 4RGCA 4HOFA 3F0QX 1RA9A 1DRBA 4XT4A 5HVBA 3IRMA 2OBCA 4TU5X 1LUDA 3DL6A 3UM5A 4QHVA 3NZAX 3NXOA 2H2QA 3JTWA 3NXYA 2C2TA 4PTJA 1S3VA 3SQYX 5HQYA 3NZ6X 4IXFX 1ZDRA 4EILA 1CD2A 1DLRA 4XECX 3K45A 2QK8A 4ELEA 4QLFA 1HFQA 4H96A 4M7VA 3FS6A 1DDRA 3DL5A 4KLXA 1DISA 5E8QA 3DFRA 2FZIA 1DR3A 3SAIA 4QLEA 5HT5A 6DFRA 3KJSA 4PDJA 1RX6A 5HUIA 2W9SA 4M2XA 4GH8A 5JA3A 2FZHA 2ANOA 4M7UA 4I13A 3IROA 3LG4A 2W3WA 4KL9A 3FQFA 3FY9X 3GYFA 1S3UA 3K2HA 1RX2A 4Q67A 1AOEA 4LAEX 3QLSA 3TD8A 4XE6X 3FYVX 3S3VA 4X5GA 4KY4A 3ROAA 2BLBA 3F8YA 3IRNA 4Q6AA 4X5JA 1DR2A 1KLKA 4EIZA 1MVTA 2HXVA 3DGAA 4XRBA 1DRFA 1LY3A 2CIGA 4KYAA 2XW7A 5HF2X 3KGYA 1JUVA 1HFRA 2BL9A 2W3AA 3JWFA 4G95A 4XT6A 3NZ9X 1U70A 3SRUX 3QYOA 1PD9A 1AO8A 3SRRX 5HSRA 3CSEA 1DR7A 4M6LA 1RX4A 3CD2A 3FL8A 3S7AA 4KM0A 3EEJA 4KFJA 1DR4A 3SR5X 1SEJA 3E0BA 1S3WA 1VDRA 4PSYA 3I8AX 3TQ9A 3I3RA 4Q0EA 3NXRA 3QLWA 4NX7A 3NTZA 4H97A 5HSUA 4HOGA 3GHVA 2B3ZA 3IA4A 2G6VA 4NX6A 4XT5A 3D80A 3QLRA 1U71A 4I1NA 1PD8A 5HVEA 2HQPA 4PSTA 1JOLA 2OIPA 4DPHA 4X5IA 3FQ0A 4G8ZX 1DAJA 4KAKA 3FQZA 1DF7A 1RA8A 4EIGA 3KFYA 4HA9A 3ZPGA 1RX7A 4DP3A 5HT4A 1RB2A 1JOMA 3K74A 1BOZA 4P3QA 1DR1A 4P68A 2W3MA 2D0KA 1YHOA 1DG8A 3QLYA 5ECXA 1IA1A 1VJ3A 1LY4A 3HBBA 1RX9A 5HI6A 5HQZA 5CC9A 2D5NA 4G3MA 4ELGA 7DFRA 3IX9A 5HF0X 4M6JA 3R33A 1DHIA 5U26A 4ELBA 4ELHA 2GD9A 3QLZA 2W3BA 1IA3A 1E26A 3ZPCA 3SA1A 3FYWX 3NXXA 1RA2A 2W3VA 3SA2A 2L28A 3RG9A 3HJ3A 1RD7A 2W9HA 5CCCA 4HA7A 4ECKA 2W9GA 3NZDA 4HOEA 2LF1A 3L3RA 1DREA 4KD7A 1OHJA 3JWCA 3GHWA 4FGGA 1DYRA 3D84X 4KJLA 1J3KA 1DLSA 1RC4A 1PDBA 1M78A 2FZJA 3DAUA 3QYLA 3TQAA 1RH3A 4KY8A 2INQA 3FQVA 3EEMA 3IA5A 1DR5A 3VCOA 3KY8A 1HFPA 3RO9A 2O7PA 3S9UA 3EEKA 3GI2A 3F0SX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DHJ A;  1RG7 A;  2DHF A;  4X5H A;  1RA1 A;  3F0B X;  3JWK A;  3M08 A;  5FDA A;  1TDR A;  3F0V X;  4KM2 A;  1J3J A;  1RA3 A;  3F0X X;  4DFR A;  3F0U X;  3QL3 A;  1AI9 A;  3DG8 A;  4FHB A;  1KMS A;  3FRF X;  3SRQ X;  1U72 A;  3NZC X;  1RX8 A;  3K47 A;  2DRC A;  3JWM A;  3SRS X;  5U27 A;  1BZF A;  3EX8 A;  3NXT A;  3KJR A;  3FRD X;  3UM8 A;  1DYJ A;  1RX3 A;  3FRB X;  4PSS A;  2JYB A;  3SH2 A;  1RE7 A;  4DPD A;  4P66 A;  3NRR A;  3JW5 A;  1CZ3 A;  1IA2 A;  3Q1H A;  4PTH A;  3NU0 A;  3FRA X;  4P3R A;  1DRH A;  4ELF A;  1DR6 A;  5HPB A;  3QFX A;  4LEK X;  1IA4 A;  5JG0 X;  3N0H A;  3FQO A;  3CLB A;  3FY8 X;  2BLC A;  1OHK A;  3SGY A;  3FL9 A;  1M79 A;  2AZN A;  4KBN A;  3TQB A;  1DG7 A;  4KJJ A;  1DDS A;  4OR7 A;  4LAH X;  3NXV A;  1DRA A;  2HM9 A;  3F91 A;  5DFR A;  1DHF A;  3INV A;  1RX1 A;  3QGT A;  3OAF A;  3OCH A;  2BLA A;  1DYH A;  4H95 A;  4FGH A;  4OSG A;  4QLG A;  4KEB A;  4M6K A;  4X5F A;  4XT7 A;  4EJ1 A;  3M09 A;  2ITH A;  2W9T A;  2P4G A;  4H98 A;  1J3I A;  3JVX A;  1DIU A;  3DRC A;  4QI9 A;  3QG2 A;  3CL9 A;  5ECC A;  4QJZ D;  3FQC A;  3F8Z A;  2C2S A;  5DXV A;  8DFR A;  3EIG A;  4Q0D A;  4LAG X;  1RX5 A;  2ANQ A;  3UM6 A;  4CD2 A;  1KMV A;  3FRE X;  1RB3 A;  3SRW X;  1D1G A;  1DG5 A;  4IXE D;  3GHC A;  3JSU A;  1M7A A;  1MVS A;  5EAJ A;  1RF7 A;  2ZZA A;  3JW3 A;  1QZF A;  1S3Y A;  3NZB X;  4KJK A;  4KNE A;  2CD2 A;  3QLX A;  3QL0 A;  1DYI A;  4DDR A;  3TQ8 A;  3DAT A;  4QJC A;  4XT8 A;  2KGK A;  4IXG X;  3EEL A;  4RGC A;  4HOF A;  3F0Q X;  1RA9 A;  1DRB A;  4XT4 A;  5HVB A;  3IRM A;  2OBC A;  4TU5 X;  1LUD A;  3DL6 A;  3UM5 A;  4QHV A;  3NZA X;  3NXO A;  2H2Q A;  3JTW A;  3NXY A;  2C2T A;  4PTJ A;  1S3V A;  3SQY X;  5HQY A;  3NZ6 X;  4IXF X;  1ZDR A;  4EIL A;  1CD2 A;  1DLR A;  4XEC X;  3K45 A;  2QK8 A;  4ELE A;  4QLF A;  1HFQ A;  4H96 A;  4M7V A;  3FS6 A;  1DDR A;  3DL5 A;  4KLX A;  1DIS A;  5E8Q A;  3DFR A;  2FZI A;  1DR3 A;  3SAI A;  4QLE A;  5HT5 A;  6DFR A;  3KJS A;  4PDJ A;  1RX6 A;  5HUI A;  2W9S A;  4M2X A;  4GH8 A;  5JA3 A;  2FZH A;  2ANO A;  4M7U A;  4I13 A;  3IRO A;  3LG4 A;  2W3W A;  4KL9 A;  3FQF A;  3FY9 X;  3GYF A;  1S3U A;  3K2H A;  1RX2 A;  4Q67 A;  1AOE A;  4LAE X;  3QLS A;  3TD8 A;  4XE6 X;  3FYV X;  3S3V A;  4X5G A;  4KY4 A;  3ROA A;  2BLB A;  3F8Y A;  3IRN A;  4Q6A A;  4X5J A;  1DR2 A;  1KLK A;  4EIZ A;  1MVT A;  2HXV A;  3DGA A;  4XRB A;  1DRF A;  1LY3 A;  2CIG A;  4KYA A;  2XW7 A;  5HF2 X;  3KGY A;  1JUV A;  1HFR A;  2BL9 A;  2W3A A;  3JWF A;  4G95 A;  4XT6 A;  3NZ9 X;  1U70 A;  3SRU X;  3QYO A;  1PD9 A;  1AO8 A;  3SRR X;  5HSR A;  3CSE A;  1DR7 A;  4M6L A;  1RX4 A;  3CD2 A;  3FL8 A;  3S7A A;  4KM0 A;  3EEJ A;  4KFJ A;  1DR4 A;  3SR5 X;  1SEJ A;  3E0B A;  1S3W A;  1VDR A;  4PSY A;  3I8A X;  3TQ9 A;  3I3R A;  4Q0E A;  3NXR A;  3QLW A;  4NX7 A;  3NTZ A;  4H97 A;  5HSU A;  4HOG A;  3GHV A;  2B3Z A;  3IA4 A;  2G6V A;  4NX6 A;  4XT5 A;  3D80 A;  3QLR A;  1U71 A;  4I1N A;  1PD8 A;  5HVE A;  2HQP A;  4PST A;  1JOL A;  2OIP A;  4DPH A;  4X5I A;  3FQ0 A;  4G8Z X;  1DAJ A;  4KAK A;  3FQZ A;  1DF7 A;  1RA8 A;  4EIG A;  3KFY A;  4HA9 A;  3ZPG A;  1RX7 A;  4DP3 A;  5HT4 A;  1RB2 A;  1JOM A;  3K74 A;  1BOZ A;  4P3Q A;  1DR1 A;  4P68 A;  2W3M A;  2D0K A;  1YHO A;  1DG8 A;  3QLY A;  5ECX A;  1IA1 A;  1VJ3 A;  1LY4 A;  3HBB A;  1RX9 A;  5HI6 A;  5HQZ A;  5CC9 A;  2D5N A;  4G3M A;  4ELG A;  7DFR A;  3IX9 A;  5HF0 X;  4M6J A;  3R33 A;  1DHI A;  5U26 A;  4ELB A;  4ELH A;  2GD9 A;  3QLZ A;  2W3B A;  1IA3 A;  1E26 A;  3ZPC A;  3SA1 A;  3FYW X;  3NXX A;  1RA2 A;  2W3V A;  3SA2 A;  2L28 A;  3RG9 A;  3HJ3 A;  1RD7 A;  2W9H A;  5CCC A;  4HA7 A;  4ECK A;  2W9G A;  3NZD A;  4HOE A;  2LF1 A;  3L3R A;  1DRE A;  4KD7 A;  1OHJ A;  3JWC A;  3GHW A;  4FGG A;  1DYR A;  3D84 X;  4KJL A;  1J3K A;  1DLS A;  1RC4 A;  1PDB A;  1M78 A;  2FZJ A;  3DAU A;  3QYL A;  3TQA A;  1RH3 A;  4KY8 A;  2INQ A;  3FQV A;  3EEM A;  3IA5 A;  1DR5 A;  3VCO A;  3KY8 A;  1HFP A;  3RO9 A;  2O7P A;  3S9U A;  3EEK A;  3GI2 A;  3F0S X; 
#chains in the Genus database with same CATH topology
 1DHJ A;  1RG7 A;  2DHF A;  4X5H A;  1RA1 A;  3F0B X;  3JWK A;  3M08 A;  5FDA A;  1TDR A;  3F0V X;  4KM2 A;  1J3J A;  1RA3 A;  3F0X X;  4DFR A;  3F0U X;  3QL3 A;  1AI9 A;  3DG8 A;  4FHB A;  1KMS A;  3FRF X;  3SRQ X;  1U72 A;  3NZC X;  1RX8 A;  3K47 A;  2DRC A;  3JWM A;  3SRS X;  5U27 A;  1BZF A;  3EX8 A;  3NXT A;  3KJR A;  3FRD X;  3UM8 A;  1DYJ A;  1RX3 A;  3FRB X;  4PSS A;  2JYB A;  3SH2 A;  1RE7 A;  4DPD A;  4P66 A;  3NRR A;  3JW5 A;  1CZ3 A;  1IA2 A;  3Q1H A;  4PTH A;  3NU0 A;  3FRA X;  4P3R A;  1DRH A;  4ELF A;  1DR6 A;  5HPB A;  3QFX A;  4LEK X;  1IA4 A;  5JG0 X;  3N0H A;  3FQO A;  3CLB A;  3FY8 X;  2BLC A;  1OHK A;  3SGY A;  3FL9 A;  1M79 A;  2AZN A;  4KBN A;  3TQB A;  1DG7 A;  4KJJ A;  1DDS A;  4OR7 A;  4LAH X;  3NXV A;  1DRA A;  2HM9 A;  3F91 A;  5DFR A;  1DHF A;  3INV A;  1RX1 A;  3QGT A;  3OAF A;  3OCH A;  2BLA A;  1DYH A;  4H95 A;  4FGH A;  4OSG A;  4QLG A;  4KEB A;  4M6K A;  4X5F A;  4XT7 A;  4EJ1 A;  3M09 A;  2ITH A;  2W9T A;  2P4G A;  4H98 A;  1J3I A;  3JVX A;  1DIU A;  3DRC A;  4QI9 A;  3QG2 A;  3CL9 A;  5ECC A;  4QJZ D;  3FQC A;  3F8Z A;  2C2S A;  5DXV A;  8DFR A;  3EIG A;  4Q0D A;  4LAG X;  1RX5 A;  2ANQ A;  3UM6 A;  4CD2 A;  1KMV A;  3FRE X;  1RB3 A;  3SRW X;  1D1G A;  1DG5 A;  4IXE D;  3GHC A;  3JSU A;  1M7A A;  1MVS A;  5EAJ A;  1RF7 A;  2ZZA A;  3JW3 A;  1QZF A;  1S3Y A;  3NZB X;  4KJK A;  4KNE A;  2CD2 A;  3QLX A;  3QL0 A;  1DYI A;  4DDR A;  3TQ8 A;  3DAT A;  4QJC A;  4XT8 A;  2KGK A;  4IXG X;  3EEL A;  4RGC A;  4HOF A;  3F0Q X;  1RA9 A;  1DRB A;  4XT4 A;  5HVB A;  3IRM A;  2OBC A;  4TU5 X;  1LUD A;  3DL6 A;  3UM5 A;  4QHV A;  3NZA X;  3NXO A;  2H2Q A;  3JTW A;  3NXY A;  2C2T A;  4PTJ A;  1S3V A;  3SQY X;  5HQY A;  3NZ6 X;  4IXF X;  1ZDR A;  4EIL A;  1CD2 A;  1DLR A;  4XEC X;  3K45 A;  2QK8 A;  4ELE A;  4QLF A;  1HFQ A;  4H96 A;  4M7V A;  3FS6 A;  1DDR A;  3DL5 A;  4KLX A;  1DIS A;  5E8Q A;  3DFR A;  2FZI A;  1DR3 A;  3SAI A;  4QLE A;  5HT5 A;  6DFR A;  3KJS A;  4PDJ A;  1RX6 A;  5HUI A;  2W9S A;  4M2X A;  4GH8 A;  5JA3 A;  2FZH A;  2ANO A;  4M7U A;  4I13 A;  3IRO A;  3LG4 A;  2W3W A;  4KL9 A;  3FQF A;  3FY9 X;  3GYF A;  1S3U A;  3K2H A;  1RX2 A;  4Q67 A;  1AOE A;  4LAE X;  3QLS A;  3TD8 A;  4XE6 X;  3FYV X;  3S3V A;  4X5G A;  4KY4 A;  3ROA A;  2BLB A;  3F8Y A;  3IRN A;  4Q6A A;  4X5J A;  1DR2 A;  1KLK A;  4EIZ A;  1MVT A;  2HXV A;  3DGA A;  4XRB A;  1DRF A;  1LY3 A;  2CIG A;  4KYA A;  2XW7 A;  5HF2 X;  3KGY A;  1JUV A;  1HFR A;  2BL9 A;  2W3A A;  3JWF A;  4G95 A;  4XT6 A;  3NZ9 X;  1U70 A;  3SRU X;  3QYO A;  1PD9 A;  1AO8 A;  3SRR X;  5HSR A;  3CSE A;  1DR7 A;  4M6L A;  1RX4 A;  3CD2 A;  3FL8 A;  3S7A A;  4KM0 A;  3EEJ A;  4KFJ A;  1DR4 A;  3SR5 X;  1SEJ A;  3E0B A;  1S3W A;  1VDR A;  4PSY A;  3I8A X;  3TQ9 A;  3I3R A;  4Q0E A;  3NXR A;  3QLW A;  4NX7 A;  3NTZ A;  4H97 A;  5HSU A;  4HOG A;  3GHV A;  2B3Z A;  3IA4 A;  2G6V A;  4NX6 A;  4XT5 A;  3D80 A;  3QLR A;  1U71 A;  4I1N A;  1PD8 A;  5HVE A;  2HQP A;  4PST A;  1JOL A;  2OIP A;  4DPH A;  4X5I A;  3FQ0 A;  4G8Z X;  1DAJ A;  4KAK A;  3FQZ A;  1DF7 A;  1RA8 A;  4EIG A;  3KFY A;  4HA9 A;  3ZPG A;  1RX7 A;  4DP3 A;  5HT4 A;  1RB2 A;  1JOM A;  3K74 A;  1BOZ A;  4P3Q A;  1DR1 A;  4P68 A;  2W3M A;  2D0K A;  1YHO A;  1DG8 A;  3QLY A;  5ECX A;  1IA1 A;  1VJ3 A;  1LY4 A;  3HBB A;  1RX9 A;  5HI6 A;  5HQZ A;  5CC9 A;  2D5N A;  4G3M A;  4ELG A;  7DFR A;  3IX9 A;  5HF0 X;  4M6J A;  3R33 A;  1DHI A;  5U26 A;  4ELB A;  4ELH A;  2GD9 A;  3QLZ A;  2W3B A;  1IA3 A;  1E26 A;  3ZPC A;  3SA1 A;  3FYW X;  3NXX A;  1RA2 A;  2W3V A;  3SA2 A;  2L28 A;  3RG9 A;  3HJ3 A;  1RD7 A;  2W9H A;  5CCC A;  4HA7 A;  4ECK A;  2W9G A;  3NZD A;  4HOE A;  2LF1 A;  3L3R A;  1DRE A;  4KD7 A;  1OHJ A;  3JWC A;  3GHW A;  4FGG A;  1DYR A;  3D84 X;  4KJL A;  1J3K A;  1DLS A;  1RC4 A;  1PDB A;  1M78 A;  2FZJ A;  3DAU A;  3QYL A;  3TQA A;  1RH3 A;  4KY8 A;  2INQ A;  3FQV A;  3EEM A;  3IA5 A;  1DR5 A;  3VCO A;  3KY8 A;  1HFP A;  3RO9 A;  2O7P A;  3S9U A;  3EEK A;  3GI2 A;  3F0S X; 
#chains in the Genus database with same CATH homology
 1DHJ A;  1RG7 A;  2DHF A;  4X5H A;  1RA1 A;  3F0B X;  3JWK A;  3M08 A;  5FDA A;  1TDR A;  3F0V X;  4KM2 A;  1J3J A;  1RA3 A;  3F0X X;  4DFR A;  3F0U X;  3QL3 A;  1AI9 A;  3DG8 A;  4FHB A;  1KMS A;  3FRF X;  3SRQ X;  1U72 A;  3NZC X;  1RX8 A;  3K47 A;  2DRC A;  3JWM A;  3SRS X;  5U27 A;  1BZF A;  3EX8 A;  3NXT A;  3KJR A;  3FRD X;  3UM8 A;  1DYJ A;  1RX3 A;  3FRB X;  4PSS A;  2JYB A;  3SH2 A;  1RE7 A;  4DPD A;  4P66 A;  3NRR A;  3JW5 A;  1CZ3 A;  1IA2 A;  3Q1H A;  4PTH A;  3NU0 A;  3FRA X;  4P3R A;  1DRH A;  4ELF A;  1DR6 A;  5HPB A;  3QFX A;  4LEK X;  1IA4 A;  5JG0 X;  3N0H A;  3FQO A;  3CLB A;  3FY8 X;  2BLC A;  1OHK A;  3SGY A;  3FL9 A;  1M79 A;  2AZN A;  4KBN A;  3TQB A;  1DG7 A;  4KJJ A;  1DDS A;  4OR7 A;  4LAH X;  3NXV A;  1DRA A;  2HM9 A;  3F91 A;  5DFR A;  1DHF A;  3INV A;  1RX1 A;  3QGT A;  3OAF A;  3OCH A;  2BLA A;  1DYH A;  4H95 A;  4FGH A;  4OSG A;  4QLG A;  4KEB A;  4M6K A;  4X5F A;  4XT7 A;  4EJ1 A;  3M09 A;  2ITH A;  2W9T A;  2P4G A;  4H98 A;  1J3I A;  3JVX A;  1DIU A;  3DRC A;  4QI9 A;  3QG2 A;  3CL9 A;  5ECC A;  4QJZ D;  3FQC A;  3F8Z A;  2C2S A;  5DXV A;  8DFR A;  3EIG A;  4Q0D A;  4LAG X;  1RX5 A;  2ANQ A;  3UM6 A;  4CD2 A;  1KMV A;  3FRE X;  1RB3 A;  3SRW X;  1D1G A;  1DG5 A;  4IXE D;  3GHC A;  3JSU A;  1M7A A;  1MVS A;  5EAJ A;  1RF7 A;  2ZZA A;  3JW3 A;  1QZF A;  1S3Y A;  3NZB X;  4KJK A;  4KNE A;  2CD2 A;  3QLX A;  3QL0 A;  1DYI A;  4DDR A;  3TQ8 A;  3DAT A;  4QJC A;  4XT8 A;  2KGK A;  4IXG X;  3EEL A;  4RGC A;  4HOF A;  3F0Q X;  1RA9 A;  1DRB A;  4XT4 A;  5HVB A;  3IRM A;  2OBC A;  4TU5 X;  1LUD A;  3DL6 A;  3UM5 A;  4QHV A;  3NZA X;  3NXO A;  2H2Q A;  3JTW A;  3NXY A;  2C2T A;  4PTJ A;  1S3V A;  3SQY X;  5HQY A;  3NZ6 X;  4IXF X;  1ZDR A;  4EIL A;  1CD2 A;  1DLR A;  4XEC X;  3K45 A;  2QK8 A;  4ELE A;  4QLF A;  1HFQ A;  4H96 A;  4M7V A;  3FS6 A;  1DDR A;  3DL5 A;  4KLX A;  1DIS A;  5E8Q A;  3DFR A;  2FZI A;  1DR3 A;  3SAI A;  4QLE A;  5HT5 A;  6DFR A;  3KJS A;  4PDJ A;  1RX6 A;  5HUI A;  2W9S A;  4M2X A;  4GH8 A;  5JA3 A;  2FZH A;  2ANO A;  4M7U A;  4I13 A;  3IRO A;  3LG4 A;  2W3W A;  4KL9 A;  3FQF A;  3FY9 X;  3GYF A;  1S3U A;  3K2H A;  1RX2 A;  4Q67 A;  1AOE A;  4LAE X;  3QLS A;  3TD8 A;  4XE6 X;  3FYV X;  3S3V A;  4X5G A;  4KY4 A;  3ROA A;  2BLB A;  3F8Y A;  3IRN A;  4Q6A A;  4X5J A;  1DR2 A;  1KLK A;  4EIZ A;  1MVT A;  2HXV A;  3DGA A;  4XRB A;  1DRF A;  1LY3 A;  2CIG A;  4KYA A;  2XW7 A;  5HF2 X;  3KGY A;  1JUV A;  1HFR A;  2BL9 A;  2W3A A;  3JWF A;  4G95 A;  4XT6 A;  3NZ9 X;  1U70 A;  3SRU X;  3QYO A;  1PD9 A;  1AO8 A;  3SRR X;  5HSR A;  3CSE A;  1DR7 A;  4M6L A;  1RX4 A;  3CD2 A;  3FL8 A;  3S7A A;  4KM0 A;  3EEJ A;  4KFJ A;  1DR4 A;  3SR5 X;  1SEJ A;  3E0B A;  1S3W A;  1VDR A;  4PSY A;  3I8A X;  3TQ9 A;  3I3R A;  4Q0E A;  3NXR A;  3QLW A;  4NX7 A;  3NTZ A;  4H97 A;  5HSU A;  4HOG A;  3GHV A;  2B3Z A;  3IA4 A;  2G6V A;  4NX6 A;  4XT5 A;  3D80 A;  3QLR A;  1U71 A;  4I1N A;  1PD8 A;  5HVE A;  2HQP A;  4PST A;  1JOL A;  2OIP A;  4DPH A;  4X5I A;  3FQ0 A;  4G8Z X;  1DAJ A;  4KAK A;  3FQZ A;  1DF7 A;  1RA8 A;  4EIG A;  3KFY A;  4HA9 A;  3ZPG A;  1RX7 A;  4DP3 A;  5HT4 A;  1RB2 A;  1JOM A;  3K74 A;  1BOZ A;  4P3Q A;  1DR1 A;  4P68 A;  2W3M A;  2D0K A;  1YHO A;  1DG8 A;  3QLY A;  5ECX A;  1IA1 A;  1VJ3 A;  1LY4 A;  3HBB A;  1RX9 A;  5HI6 A;  5HQZ A;  5CC9 A;  2D5N A;  4G3M A;  4ELG A;  7DFR A;  3IX9 A;  5HF0 X;  4M6J A;  3R33 A;  1DHI A;  5U26 A;  4ELB A;  4ELH A;  2GD9 A;  3QLZ A;  2W3B A;  1IA3 A;  1E26 A;  3ZPC A;  3SA1 A;  3FYW X;  3NXX A;  1RA2 A;  2W3V A;  3SA2 A;  2L28 A;  3RG9 A;  3HJ3 A;  1RD7 A;  2W9H A;  5CCC A;  4HA7 A;  4ECK A;  2W9G A;  3NZD A;  4HOE A;  2LF1 A;  3L3R A;  1DRE A;  4KD7 A;  1OHJ A;  3JWC A;  3GHW A;  4FGG A;  1DYR A;  3D84 X;  4KJL A;  1J3K A;  1DLS A;  1RC4 A;  1PDB A;  1M78 A;  2FZJ A;  3DAU A;  3QYL A;  3TQA A;  1RH3 A;  4KY8 A;  2INQ A;  3FQV A;  3EEM A;  3IA5 A;  1DR5 A;  3VCO A;  3KY8 A;  1HFP A;  3RO9 A;  2O7P A;  3S9U A;  3EEK A;  3GI2 A;  3F0S X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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