2W3BA

Human dihydrofolate reductase complexed with nadph and a lipophilic antifolate selective for mycobacterium avium dhfr, 6-((2,5- diethoxyphenyl)aminomethyl)-2,4-diamino-5-methylpyrido(2,3-d) pyrimidine (sri-8686)
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
185
structure length
185
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate
rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 49
structure length 185
sequence length 185
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2008-11-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 2w3bA00
4HA9A 2JYBA 3NZCX 3DGAA 3I8AX 4HOGA 4XT6A 3SGYA 3QLSA 3IA4A 1QZFA 3NRRA 3NXRA 3GHWA 3FS6A 2AZNA 3JWMA 1DRFA 1VDRA 3QYLA 4LAHX 5U26A 4X5IA 1U72A 2BLCA 3QFXA 4KJKA 1LY4A 2DHFA 3GI2A 4M6LA 1J3JA 1U71A 3F0SX 1ZDRA 4QLGA 3UM8A 3CL9A 2BLBA 3QLRA 1DYRA 2LF1A 3F91A 4NX7A 2OBCA 1E26A 1DR2A 3FQZA 1LUDA 4KD7A 1DR5A 1M79A 3JWKA 1S3UA 4KFJA 4TU5X 2FZJA 2W9SA 5HSUA 3FL9A 4IXFX 1AOEA 3QLZA 3F8ZA 1CD2A 1RF7A 3SA1A 3SRWX 3M09A 3SR5X 2L28A 4KY4A 1RX3A 1DIUA 4XT7A 3NXVA 3ROAA 4X5FA 4X5GA 5DFRA 5JG0X 3F0UX 3F8YA 3HJ3A 2ANQA 3EX8A 3RO9A 3OCHA 1KMSA 4RGCA 1DYIA 2W3VA 3FREX 4M7UA 5HF0X 4KM2A 4DFRA 3S9UA 4I13A 5HT5A 3QLYA 3FRAX 1RX7A 1YHOA 4QJCA 4DP3A 3NZ9X 4ELHA 3FRDX 1DG8A 1J3IA 1CZ3A 4ELGA 4XECX 2XW7A 3IRMA 3NXOA 3NXTA 3QLWA 3NXYA 3KGYA 3TQBA 2W9GA 1RG7A 1OHJA 3F0XX 4KNEA 4GH8A 3QL3A 5HUIA 3FRBX 3IROA 3FYWX 3KJSA 4G3MA 3NXXA 4OR7A 1PD8A 3SQYX 3NZDA 3L3RA 1DLSA 3UM5A 2GD9A 1RD7A 3CD2A 2BLAA 4KAKA 3ZPCA 3S3VA 1U70A 3TQAA 1DR3A 3QLXA 1DYHA 5U27A 4ELEA 4OSGA 2ZZAA 3ZPGA 7DFRA 1M78A 5HQYA 3JTWA 1BZFA 1LY3A 4KJLA 3FQFA 1RX6A 2HXVA 1DRAA 1RA1A 4PSSA 4ELFA 3M08A 3TQ9A 4H98A 5CC9A 4Q0EA 2D0KA 1MVSA 3QGTA 4KY8A 3E0BA 3TD8A 4XT4A 4XT5A 3DL6A 2W3AA 4PTHA 3N0HA 3I3RA 3FYVX 1JOMA 5HI6A 4XE6X 4XRBA 5E8QA 2ITHA 1DR4A 1D1GA 1RA9A 3DG8A 4EIZA 4P3RA 1RX9A 3SRQX 3JVXA 1HFQA 2HM9A 3QYOA 4IXED 1DAJA 3EEKA 2BL9A 4CD2A 1RX4A 2W3MA 1DR1A 3KY8A 3FQOA 4Q67A 3D84X 4QJZD 4QHVA 2KGKA 3FQ0A 1BOZA 4KBNA 1RH3A 1MVTA 3IRNA 3OAFA 8DFRA 1DDRA 3SRUX 1DRHA 1OHKA 4P66A 3NTZA 2W9TA 1PDBA 4PTJA 1RA3A 4EJ1A 1VJ3A 2CIGA 4ECKA 3FRFX 4QLFA 4M6KA 3JSUA 1RX2A 3EEMA 1AO8A 3KFYA 1DLRA 4M7VA 4P68A 2INQA 5CCCA 4KJJA 1RA8A 3JWFA 3DFRA 4KL9A 5JA3A 1DRBA 3NZAX 4PSTA 4DPHA 3S7AA 3R33A 5ECXA 3GYFA 2W3WA 1RX1A 3NZ6X 4FHBA 3DATA 3NZBX 1S3YA 3K74A 3SA2A 1DF7A 3Q1HA 2P4GA 3LG4A 4HOEA 1DHFA 2W9HA 1KMVA 3K45A 2G6VA 3EELA 4ELBA 1HFRA 4M2XA 1RA2A 4G95A 3KJRA 3INVA 4KEBA 1KLKA 2ANOA 5HVBA 4Q0DA 3CSEA 2CD2A 3VCOA 1DHIA 4LAGX 5HPBA 1RB3A 1HFPA 1DR7A 4FGGA 3SRSX 3EEJA 2D5NA 4M6JA 3TQ8A 4PDJA 4I1NA 3QG2A 3EIGA 2OIPA 5DXVA 2C2SA 4G8ZX 4H97A 2W3BA 1DYJA 3F0QX 1RE7A 1DDSA 1DHJA 1M7AA 3HBBA 4DPDA 3K2HA 2FZIA 1RX8A 1TDRA 4LAEX 4KM0A 1S3VA 3FY8X 2C2TA 5HQZA 1PD9A 3GHCA 4LEKX 3SAIA 4IXGX 5FDAA 5HVEA 2FZHA 1RC4A 3D80A 3IX9A 3JW5A 4QI9A 4H96A 2B3ZA 3NU0A 3FY9X 4QLEA 4FGHA 4P3QA 3JWCA 3QL0A 4EILA 1RX5A 5HT4A 4DDRA 4NX6A 4X5JA 2H2QA 3FQVA 3DAUA 1AI9A 1S3WA 2QK8A 3F0VX 1DR6A 2O7PA 1SEJA 1DISA 4PSYA 5EAJA 1IA3A 5HF2X 3CLBA 3RG9A 3DL5A 3FQCA 1JUVA 4Q6AA 4KYAA 3F0BX 1J3KA 1DG5A 4X5HA 1IA4A 4KLXA 3IA5A 2DRCA 3SRRX 3FL8A 3GHVA 4HA7A 3JW3A 5HSRA 6DFRA 4H95A 1DREA 1RB2A 4XT8A 2HQPA 1DG7A 1IA2A 5ECCA 3UM6A 3SH2A 4HOFA 3DRCA 3K47A 1IA1A 4EIGA 1JOLA
chains in the Genus database with same CATH superfamily
4HA9A 2JYBA 3NZCX 3DGAA 3I8AX 4HOGA 4XT6A 3SGYA 3QLSA 3IA4A 1QZFA 3NRRA 3NXRA 3GHWA 3FS6A 2AZNA 3JWMA 1DRFA 1VDRA 3QYLA 4LAHX 5U26A 4X5IA 1U72A 2BLCA 3QFXA 4KJKA 1LY4A 2DHFA 3GI2A 4M6LA 1J3JA 1U71A 3F0SX 1ZDRA 4QLGA 3UM8A 3CL9A 2BLBA 3QLRA 1DYRA 2LF1A 3F91A 4NX7A 2OBCA 1E26A 1DR2A 3FQZA 1LUDA 4KD7A 1DR5A 1M79A 3JWKA 1S3UA 4KFJA 4TU5X 2FZJA 2W9SA 5HSUA 3FL9A 4IXFX 1AOEA 3QLZA 3F8ZA 1CD2A 1RF7A 3SA1A 3SRWX 3M09A 3SR5X 2L28A 4KY4A 1RX3A 1DIUA 4XT7A 3NXVA 3ROAA 4X5FA 4X5GA 5DFRA 5JG0X 3F0UX 3F8YA 3HJ3A 2ANQA 3EX8A 3RO9A 3OCHA 1KMSA 4RGCA 1DYIA 2W3VA 3FREX 4M7UA 5HF0X 4KM2A 4DFRA 3S9UA 4I13A 5HT5A 3QLYA 3FRAX 1RX7A 1YHOA 4QJCA 4DP3A 3NZ9X 4ELHA 3FRDX 1DG8A 1J3IA 1CZ3A 4ELGA 4XECX 2XW7A 3IRMA 3NXOA 3NXTA 3QLWA 3NXYA 3KGYA 3TQBA 2W9GA 1RG7A 1OHJA 3F0XX 4KNEA 4GH8A 3QL3A 5HUIA 3FRBX 3IROA 3FYWX 3KJSA 4G3MA 3NXXA 4OR7A 1PD8A 3SQYX 3NZDA 3L3RA 1DLSA 3UM5A 2GD9A 1RD7A 3CD2A 2BLAA 4KAKA 3ZPCA 3S3VA 1U70A 3TQAA 1DR3A 3QLXA 1DYHA 5U27A 4ELEA 4OSGA 2ZZAA 3ZPGA 7DFRA 1M78A 5HQYA 3JTWA 1BZFA 1LY3A 4KJLA 3FQFA 1RX6A 2HXVA 1DRAA 1RA1A 4PSSA 4ELFA 3M08A 3TQ9A 4H98A 5CC9A 4Q0EA 2D0KA 1MVSA 3QGTA 4KY8A 3E0BA 3TD8A 4XT4A 4XT5A 3DL6A 2W3AA 4PTHA 3N0HA 3I3RA 3FYVX 1JOMA 5HI6A 4XE6X 4XRBA 5E8QA 2ITHA 1DR4A 1D1GA 1RA9A 3DG8A 4EIZA 4P3RA 1RX9A 3SRQX 3JVXA 1HFQA 2HM9A 3QYOA 4IXED 1DAJA 3EEKA 2BL9A 4CD2A 1RX4A 2W3MA 1DR1A 3KY8A 3FQOA 4Q67A 3D84X 4QJZD 4QHVA 2KGKA 3FQ0A 1BOZA 4KBNA 1RH3A 1MVTA 3IRNA 3OAFA 8DFRA 1DDRA 3SRUX 1DRHA 1OHKA 4P66A 3NTZA 2W9TA 1PDBA 4PTJA 1RA3A 4EJ1A 1VJ3A 2CIGA 4ECKA 3FRFX 4QLFA 4M6KA 3JSUA 1RX2A 3EEMA 1AO8A 3KFYA 1DLRA 4M7VA 4P68A 2INQA 5CCCA 4KJJA 1RA8A 3JWFA 3DFRA 4KL9A 5JA3A 1DRBA 3NZAX 4PSTA 4DPHA 3S7AA 3R33A 5ECXA 3GYFA 2W3WA 1RX1A 3NZ6X 4FHBA 3DATA 3NZBX 1S3YA 3K74A 3SA2A 1DF7A 3Q1HA 2P4GA 3LG4A 4HOEA 1DHFA 2W9HA 1KMVA 3K45A 2G6VA 3EELA 4ELBA 1HFRA 4M2XA 1RA2A 4G95A 3KJRA 3INVA 4KEBA 1KLKA 2ANOA 5HVBA 4Q0DA 3CSEA 2CD2A 3VCOA 1DHIA 4LAGX 5HPBA 1RB3A 1HFPA 1DR7A 4FGGA 3SRSX 3EEJA 2D5NA 4M6JA 3TQ8A 4PDJA 4I1NA 3QG2A 3EIGA 2OIPA 5DXVA 2C2SA 4G8ZX 4H97A 2W3BA 1DYJA 3F0QX 1RE7A 1DDSA 1DHJA 1M7AA 3HBBA 4DPDA 3K2HA 2FZIA 1RX8A 1TDRA 4LAEX 4KM0A 1S3VA 3FY8X 2C2TA 5HQZA 1PD9A 3GHCA 4LEKX 3SAIA 4IXGX 5FDAA 5HVEA 2FZHA 1RC4A 3D80A 3IX9A 3JW5A 4QI9A 4H96A 2B3ZA 3NU0A 3FY9X 4QLEA 4FGHA 4P3QA 3JWCA 3QL0A 4EILA 1RX5A 5HT4A 4DDRA 4NX6A 4X5JA 2H2QA 3FQVA 3DAUA 1AI9A 1S3WA 2QK8A 3F0VX 1DR6A 2O7PA 1SEJA 1DISA 4PSYA 5EAJA 1IA3A 5HF2X 3CLBA 3RG9A 3DL5A 3FQCA 1JUVA 4Q6AA 4KYAA 3F0BX 1J3KA 1DG5A 4X5HA 1IA4A 4KLXA 3IA5A 2DRCA 3SRRX 3FL8A 3GHVA 4HA7A 3JW3A 5HSRA 6DFRA 4H95A 1DREA 1RB2A 4XT8A 2HQPA 1DG7A 1IA2A 5ECCA 3UM6A 3SH2A 4HOFA 3DRCA 3K47A 1IA1A 4EIGA 1JOLA
chains in the Genus database with same CATH topology
4HA9A 2JYBA 3NZCX 3DGAA 3I8AX 4HOGA 4XT6A 3SGYA 3QLSA 3IA4A 1QZFA 3NRRA 3NXRA 3GHWA 3FS6A 2AZNA 3JWMA 1DRFA 1VDRA 3QYLA 4LAHX 5U26A 4X5IA 1U72A 2BLCA 3QFXA 4KJKA 1LY4A 2DHFA 3GI2A 4M6LA 1J3JA 1U71A 3F0SX 1ZDRA 4QLGA 3UM8A 3CL9A 2BLBA 3QLRA 1DYRA 2LF1A 3F91A 4NX7A 2OBCA 1E26A 1DR2A 3FQZA 1LUDA 4KD7A 1DR5A 1M79A 3JWKA 1S3UA 4KFJA 4TU5X 2FZJA 2W9SA 5HSUA 3FL9A 4IXFX 1AOEA 3QLZA 3F8ZA 1CD2A 1RF7A 3SA1A 3SRWX 3M09A 3SR5X 2L28A 4KY4A 1RX3A 1DIUA 4XT7A 3NXVA 3ROAA 4X5FA 4X5GA 5DFRA 5JG0X 3F0UX 3F8YA 3HJ3A 2ANQA 3EX8A 3RO9A 3OCHA 1KMSA 4RGCA 1DYIA 2W3VA 3FREX 4M7UA 5HF0X 4KM2A 4DFRA 3S9UA 4I13A 5HT5A 3QLYA 3FRAX 1RX7A 1YHOA 4QJCA 4DP3A 3NZ9X 4ELHA 3FRDX 1DG8A 1J3IA 1CZ3A 4ELGA 4XECX 2XW7A 3IRMA 3NXOA 3NXTA 3QLWA 3NXYA 3KGYA 3TQBA 2W9GA 1RG7A 1OHJA 3F0XX 4KNEA 4GH8A 3QL3A 5HUIA 3FRBX 3IROA 3FYWX 3KJSA 4G3MA 3NXXA 4OR7A 1PD8A 3SQYX 3NZDA 3L3RA 1DLSA 3UM5A 2GD9A 1RD7A 3CD2A 2BLAA 4KAKA 3ZPCA 3S3VA 1U70A 3TQAA 1DR3A 3QLXA 1DYHA 5U27A 4ELEA 4OSGA 2ZZAA 3ZPGA 7DFRA 1M78A 5HQYA 3JTWA 1BZFA 1LY3A 4KJLA 3FQFA 1RX6A 2HXVA 1DRAA 1RA1A 4PSSA 4ELFA 3M08A 3TQ9A 4H98A 5CC9A 4Q0EA 2D0KA 1MVSA 3QGTA 4KY8A 3E0BA 3TD8A 4XT4A 4XT5A 3DL6A 2W3AA 4PTHA 3N0HA 3I3RA 3FYVX 1JOMA 5HI6A 4XE6X 4XRBA 5E8QA 2ITHA 1DR4A 1D1GA 1RA9A 3DG8A 4EIZA 4P3RA 1RX9A 3SRQX 3JVXA 1HFQA 2HM9A 3QYOA 4IXED 1DAJA 3EEKA 2BL9A 4CD2A 1RX4A 2W3MA 1DR1A 3KY8A 3FQOA 4Q67A 3D84X 4QJZD 4QHVA 2KGKA 3FQ0A 1BOZA 4KBNA 1RH3A 1MVTA 3IRNA 3OAFA 8DFRA 1DDRA 3SRUX 1DRHA 1OHKA 4P66A 3NTZA 2W9TA 1PDBA 4PTJA 1RA3A 4EJ1A 1VJ3A 2CIGA 4ECKA 3FRFX 4QLFA 4M6KA 3JSUA 1RX2A 3EEMA 1AO8A 3KFYA 1DLRA 4M7VA 4P68A 2INQA 5CCCA 4KJJA 1RA8A 3JWFA 3DFRA 4KL9A 5JA3A 1DRBA 3NZAX 4PSTA 4DPHA 3S7AA 3R33A 5ECXA 3GYFA 2W3WA 1RX1A 3NZ6X 4FHBA 3DATA 3NZBX 1S3YA 3K74A 3SA2A 1DF7A 3Q1HA 2P4GA 3LG4A 4HOEA 1DHFA 2W9HA 1KMVA 3K45A 2G6VA 3EELA 4ELBA 1HFRA 4M2XA 1RA2A 4G95A 3KJRA 3INVA 4KEBA 1KLKA 2ANOA 5HVBA 4Q0DA 3CSEA 2CD2A 3VCOA 1DHIA 4LAGX 5HPBA 1RB3A 1HFPA 1DR7A 4FGGA 3SRSX 3EEJA 2D5NA 4M6JA 3TQ8A 4PDJA 4I1NA 3QG2A 3EIGA 2OIPA 5DXVA 2C2SA 4G8ZX 4H97A 2W3BA 1DYJA 3F0QX 1RE7A 1DDSA 1DHJA 1M7AA 3HBBA 4DPDA 3K2HA 2FZIA 1RX8A 1TDRA 4LAEX 4KM0A 1S3VA 3FY8X 2C2TA 5HQZA 1PD9A 3GHCA 4LEKX 3SAIA 4IXGX 5FDAA 5HVEA 2FZHA 1RC4A 3D80A 3IX9A 3JW5A 4QI9A 4H96A 2B3ZA 3NU0A 3FY9X 4QLEA 4FGHA 4P3QA 3JWCA 3QL0A 4EILA 1RX5A 5HT4A 4DDRA 4NX6A 4X5JA 2H2QA 3FQVA 3DAUA 1AI9A 1S3WA 2QK8A 3F0VX 1DR6A 2O7PA 1SEJA 1DISA 4PSYA 5EAJA 1IA3A 5HF2X 3CLBA 3RG9A 3DL5A 3FQCA 1JUVA 4Q6AA 4KYAA 3F0BX 1J3KA 1DG5A 4X5HA 1IA4A 4KLXA 3IA5A 2DRCA 3SRRX 3FL8A 3GHVA 4HA7A 3JW3A 5HSRA 6DFRA 4H95A 1DREA 1RB2A 4XT8A 2HQPA 1DG7A 1IA2A 5ECCA 3UM6A 3SH2A 4HOFA 3DRCA 3K47A 1IA1A 4EIGA 1JOLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HA9 A;  2JYB A;  3NZC X;  3DGA A;  3I8A X;  4HOG A;  4XT6 A;  3SGY A;  3QLS A;  3IA4 A;  1QZF A;  3NRR A;  3NXR A;  3GHW A;  3FS6 A;  2AZN A;  3JWM A;  1DRF A;  1VDR A;  3QYL A;  4LAH X;  5U26 A;  4X5I A;  1U72 A;  2BLC A;  3QFX A;  4KJK A;  1LY4 A;  2DHF A;  3GI2 A;  4M6L A;  1J3J A;  1U71 A;  3F0S X;  1ZDR A;  4QLG A;  3UM8 A;  3CL9 A;  2BLB A;  3QLR A;  1DYR A;  2LF1 A;  3F91 A;  4NX7 A;  2OBC A;  1E26 A;  1DR2 A;  3FQZ A;  1LUD A;  4KD7 A;  1DR5 A;  1M79 A;  3JWK A;  1S3U A;  4KFJ A;  4TU5 X;  2FZJ A;  2W9S A;  5HSU A;  3FL9 A;  4IXF X;  1AOE A;  3QLZ A;  3F8Z A;  1CD2 A;  1RF7 A;  3SA1 A;  3SRW X;  3M09 A;  3SR5 X;  2L28 A;  4KY4 A;  1RX3 A;  1DIU A;  4XT7 A;  3NXV A;  3ROA A;  4X5F A;  4X5G A;  5DFR A;  5JG0 X;  3F0U X;  3F8Y A;  3HJ3 A;  2ANQ A;  3EX8 A;  3RO9 A;  3OCH A;  1KMS A;  4RGC A;  1DYI A;  2W3V A;  3FRE X;  4M7U A;  5HF0 X;  4KM2 A;  4DFR A;  3S9U A;  4I13 A;  5HT5 A;  3QLY A;  3FRA X;  1RX7 A;  1YHO A;  4QJC A;  4DP3 A;  3NZ9 X;  4ELH A;  3FRD X;  1DG8 A;  1J3I A;  1CZ3 A;  4ELG A;  4XEC X;  2XW7 A;  3IRM A;  3NXO A;  3NXT A;  3QLW A;  3NXY A;  3KGY A;  3TQB A;  2W9G A;  1RG7 A;  1OHJ A;  3F0X X;  4KNE A;  4GH8 A;  3QL3 A;  5HUI A;  3FRB X;  3IRO A;  3FYW X;  3KJS A;  4G3M A;  3NXX A;  4OR7 A;  1PD8 A;  3SQY X;  3NZD A;  3L3R A;  1DLS A;  3UM5 A;  2GD9 A;  1RD7 A;  3CD2 A;  2BLA A;  4KAK A;  3ZPC A;  3S3V A;  1U70 A;  3TQA A;  1DR3 A;  3QLX A;  1DYH A;  5U27 A;  4ELE A;  4OSG A;  2ZZA A;  3ZPG A;  7DFR A;  1M78 A;  5HQY A;  3JTW A;  1BZF A;  1LY3 A;  4KJL A;  3FQF A;  1RX6 A;  2HXV A;  1DRA A;  1RA1 A;  4PSS A;  4ELF A;  3M08 A;  3TQ9 A;  4H98 A;  5CC9 A;  4Q0E A;  2D0K A;  1MVS A;  3QGT A;  4KY8 A;  3E0B A;  3TD8 A;  4XT4 A;  4XT5 A;  3DL6 A;  2W3A A;  4PTH A;  3N0H A;  3I3R A;  3FYV X;  1JOM A;  5HI6 A;  4XE6 X;  4XRB A;  5E8Q A;  2ITH A;  1DR4 A;  1D1G A;  1RA9 A;  3DG8 A;  4EIZ A;  4P3R A;  1RX9 A;  3SRQ X;  3JVX A;  1HFQ A;  2HM9 A;  3QYO A;  4IXE D;  1DAJ A;  3EEK A;  2BL9 A;  4CD2 A;  1RX4 A;  2W3M A;  1DR1 A;  3KY8 A;  3FQO A;  4Q67 A;  3D84 X;  4QJZ D;  4QHV A;  2KGK A;  3FQ0 A;  1BOZ A;  4KBN A;  1RH3 A;  1MVT A;  3IRN A;  3OAF A;  8DFR A;  1DDR A;  3SRU X;  1DRH A;  1OHK A;  4P66 A;  3NTZ A;  2W9T A;  1PDB A;  4PTJ A;  1RA3 A;  4EJ1 A;  1VJ3 A;  2CIG A;  4ECK A;  3FRF X;  4QLF A;  4M6K A;  3JSU A;  1RX2 A;  3EEM A;  1AO8 A;  3KFY A;  1DLR A;  4M7V A;  4P68 A;  2INQ A;  5CCC A;  4KJJ A;  1RA8 A;  3JWF A;  3DFR A;  4KL9 A;  5JA3 A;  1DRB A;  3NZA X;  4PST A;  4DPH A;  3S7A A;  3R33 A;  5ECX A;  3GYF A;  2W3W A;  1RX1 A;  3NZ6 X;  4FHB A;  3DAT A;  3NZB X;  1S3Y A;  3K74 A;  3SA2 A;  1DF7 A;  3Q1H A;  2P4G A;  3LG4 A;  4HOE A;  1DHF A;  2W9H A;  1KMV A;  3K45 A;  2G6V A;  3EEL A;  4ELB A;  1HFR A;  4M2X A;  1RA2 A;  4G95 A;  3KJR A;  3INV A;  4KEB A;  1KLK A;  2ANO A;  5HVB A;  4Q0D A;  3CSE A;  2CD2 A;  3VCO A;  1DHI A;  4LAG X;  5HPB A;  1RB3 A;  1HFP A;  1DR7 A;  4FGG A;  3SRS X;  3EEJ A;  2D5N A;  4M6J A;  3TQ8 A;  4PDJ A;  4I1N A;  3QG2 A;  3EIG A;  2OIP A;  5DXV A;  2C2S A;  4G8Z X;  4H97 A;  2W3B A;  1DYJ A;  3F0Q X;  1RE7 A;  1DDS A;  1DHJ A;  1M7A A;  3HBB A;  4DPD A;  3K2H A;  2FZI A;  1RX8 A;  1TDR A;  4LAE X;  4KM0 A;  1S3V A;  3FY8 X;  2C2T A;  5HQZ A;  1PD9 A;  3GHC A;  4LEK X;  3SAI A;  4IXG X;  5FDA A;  5HVE A;  2FZH A;  1RC4 A;  3D80 A;  3IX9 A;  3JW5 A;  4QI9 A;  4H96 A;  2B3Z A;  3NU0 A;  3FY9 X;  4QLE A;  4FGH A;  4P3Q A;  3JWC A;  3QL0 A;  4EIL A;  1RX5 A;  5HT4 A;  4DDR A;  4NX6 A;  4X5J A;  2H2Q A;  3FQV A;  3DAU A;  1AI9 A;  1S3W A;  2QK8 A;  3F0V X;  1DR6 A;  2O7P A;  1SEJ A;  1DIS A;  4PSY A;  5EAJ A;  1IA3 A;  5HF2 X;  3CLB A;  3RG9 A;  3DL5 A;  3FQC A;  1JUV A;  4Q6A A;  4KYA A;  3F0B X;  1J3K A;  1DG5 A;  4X5H A;  1IA4 A;  4KLX A;  3IA5 A;  2DRC A;  3SRR X;  3FL8 A;  3GHV A;  4HA7 A;  3JW3 A;  5HSR A;  6DFR A;  4H95 A;  1DRE A;  1RB2 A;  4XT8 A;  2HQP A;  1DG7 A;  1IA2 A;  5ECC A;  3UM6 A;  3SH2 A;  4HOF A;  3DRC A;  3K47 A;  1IA1 A;  4EIG A;  1JOL A; 
#chains in the Genus database with same CATH topology
 4HA9 A;  2JYB A;  3NZC X;  3DGA A;  3I8A X;  4HOG A;  4XT6 A;  3SGY A;  3QLS A;  3IA4 A;  1QZF A;  3NRR A;  3NXR A;  3GHW A;  3FS6 A;  2AZN A;  3JWM A;  1DRF A;  1VDR A;  3QYL A;  4LAH X;  5U26 A;  4X5I A;  1U72 A;  2BLC A;  3QFX A;  4KJK A;  1LY4 A;  2DHF A;  3GI2 A;  4M6L A;  1J3J A;  1U71 A;  3F0S X;  1ZDR A;  4QLG A;  3UM8 A;  3CL9 A;  2BLB A;  3QLR A;  1DYR A;  2LF1 A;  3F91 A;  4NX7 A;  2OBC A;  1E26 A;  1DR2 A;  3FQZ A;  1LUD A;  4KD7 A;  1DR5 A;  1M79 A;  3JWK A;  1S3U A;  4KFJ A;  4TU5 X;  2FZJ A;  2W9S A;  5HSU A;  3FL9 A;  4IXF X;  1AOE A;  3QLZ A;  3F8Z A;  1CD2 A;  1RF7 A;  3SA1 A;  3SRW X;  3M09 A;  3SR5 X;  2L28 A;  4KY4 A;  1RX3 A;  1DIU A;  4XT7 A;  3NXV A;  3ROA A;  4X5F A;  4X5G A;  5DFR A;  5JG0 X;  3F0U X;  3F8Y A;  3HJ3 A;  2ANQ A;  3EX8 A;  3RO9 A;  3OCH A;  1KMS A;  4RGC A;  1DYI A;  2W3V A;  3FRE X;  4M7U A;  5HF0 X;  4KM2 A;  4DFR A;  3S9U A;  4I13 A;  5HT5 A;  3QLY A;  3FRA X;  1RX7 A;  1YHO A;  4QJC A;  4DP3 A;  3NZ9 X;  4ELH A;  3FRD X;  1DG8 A;  1J3I A;  1CZ3 A;  4ELG A;  4XEC X;  2XW7 A;  3IRM A;  3NXO A;  3NXT A;  3QLW A;  3NXY A;  3KGY A;  3TQB A;  2W9G A;  1RG7 A;  1OHJ A;  3F0X X;  4KNE A;  4GH8 A;  3QL3 A;  5HUI A;  3FRB X;  3IRO A;  3FYW X;  3KJS A;  4G3M A;  3NXX A;  4OR7 A;  1PD8 A;  3SQY X;  3NZD A;  3L3R A;  1DLS A;  3UM5 A;  2GD9 A;  1RD7 A;  3CD2 A;  2BLA A;  4KAK A;  3ZPC A;  3S3V A;  1U70 A;  3TQA A;  1DR3 A;  3QLX A;  1DYH A;  5U27 A;  4ELE A;  4OSG A;  2ZZA A;  3ZPG A;  7DFR A;  1M78 A;  5HQY A;  3JTW A;  1BZF A;  1LY3 A;  4KJL A;  3FQF A;  1RX6 A;  2HXV A;  1DRA A;  1RA1 A;  4PSS A;  4ELF A;  3M08 A;  3TQ9 A;  4H98 A;  5CC9 A;  4Q0E A;  2D0K A;  1MVS A;  3QGT A;  4KY8 A;  3E0B A;  3TD8 A;  4XT4 A;  4XT5 A;  3DL6 A;  2W3A A;  4PTH A;  3N0H A;  3I3R A;  3FYV X;  1JOM A;  5HI6 A;  4XE6 X;  4XRB A;  5E8Q A;  2ITH A;  1DR4 A;  1D1G A;  1RA9 A;  3DG8 A;  4EIZ A;  4P3R A;  1RX9 A;  3SRQ X;  3JVX A;  1HFQ A;  2HM9 A;  3QYO A;  4IXE D;  1DAJ A;  3EEK A;  2BL9 A;  4CD2 A;  1RX4 A;  2W3M A;  1DR1 A;  3KY8 A;  3FQO A;  4Q67 A;  3D84 X;  4QJZ D;  4QHV A;  2KGK A;  3FQ0 A;  1BOZ A;  4KBN A;  1RH3 A;  1MVT A;  3IRN A;  3OAF A;  8DFR A;  1DDR A;  3SRU X;  1DRH A;  1OHK A;  4P66 A;  3NTZ A;  2W9T A;  1PDB A;  4PTJ A;  1RA3 A;  4EJ1 A;  1VJ3 A;  2CIG A;  4ECK A;  3FRF X;  4QLF A;  4M6K A;  3JSU A;  1RX2 A;  3EEM A;  1AO8 A;  3KFY A;  1DLR A;  4M7V A;  4P68 A;  2INQ A;  5CCC A;  4KJJ A;  1RA8 A;  3JWF A;  3DFR A;  4KL9 A;  5JA3 A;  1DRB A;  3NZA X;  4PST A;  4DPH A;  3S7A A;  3R33 A;  5ECX A;  3GYF A;  2W3W A;  1RX1 A;  3NZ6 X;  4FHB A;  3DAT A;  3NZB X;  1S3Y A;  3K74 A;  3SA2 A;  1DF7 A;  3Q1H A;  2P4G A;  3LG4 A;  4HOE A;  1DHF A;  2W9H A;  1KMV A;  3K45 A;  2G6V A;  3EEL A;  4ELB A;  1HFR A;  4M2X A;  1RA2 A;  4G95 A;  3KJR A;  3INV A;  4KEB A;  1KLK A;  2ANO A;  5HVB A;  4Q0D A;  3CSE A;  2CD2 A;  3VCO A;  1DHI A;  4LAG X;  5HPB A;  1RB3 A;  1HFP A;  1DR7 A;  4FGG A;  3SRS X;  3EEJ A;  2D5N A;  4M6J A;  3TQ8 A;  4PDJ A;  4I1N A;  3QG2 A;  3EIG A;  2OIP A;  5DXV A;  2C2S A;  4G8Z X;  4H97 A;  2W3B A;  1DYJ A;  3F0Q X;  1RE7 A;  1DDS A;  1DHJ A;  1M7A A;  3HBB A;  4DPD A;  3K2H A;  2FZI A;  1RX8 A;  1TDR A;  4LAE X;  4KM0 A;  1S3V A;  3FY8 X;  2C2T A;  5HQZ A;  1PD9 A;  3GHC A;  4LEK X;  3SAI A;  4IXG X;  5FDA A;  5HVE A;  2FZH A;  1RC4 A;  3D80 A;  3IX9 A;  3JW5 A;  4QI9 A;  4H96 A;  2B3Z A;  3NU0 A;  3FY9 X;  4QLE A;  4FGH A;  4P3Q A;  3JWC A;  3QL0 A;  4EIL A;  1RX5 A;  5HT4 A;  4DDR A;  4NX6 A;  4X5J A;  2H2Q A;  3FQV A;  3DAU A;  1AI9 A;  1S3W A;  2QK8 A;  3F0V X;  1DR6 A;  2O7P A;  1SEJ A;  1DIS A;  4PSY A;  5EAJ A;  1IA3 A;  5HF2 X;  3CLB A;  3RG9 A;  3DL5 A;  3FQC A;  1JUV A;  4Q6A A;  4KYA A;  3F0B X;  1J3K A;  1DG5 A;  4X5H A;  1IA4 A;  4KLX A;  3IA5 A;  2DRC A;  3SRR X;  3FL8 A;  3GHV A;  4HA7 A;  3JW3 A;  5HSR A;  6DFR A;  4H95 A;  1DRE A;  1RB2 A;  4XT8 A;  2HQP A;  1DG7 A;  1IA2 A;  5ECC A;  3UM6 A;  3SH2 A;  4HOF A;  3DRC A;  3K47 A;  1IA1 A;  4EIG A;  1JOL A; 
#chains in the Genus database with same CATH homology
 4HA9 A;  2JYB A;  3NZC X;  3DGA A;  3I8A X;  4HOG A;  4XT6 A;  3SGY A;  3QLS A;  3IA4 A;  1QZF A;  3NRR A;  3NXR A;  3GHW A;  3FS6 A;  2AZN A;  3JWM A;  1DRF A;  1VDR A;  3QYL A;  4LAH X;  5U26 A;  4X5I A;  1U72 A;  2BLC A;  3QFX A;  4KJK A;  1LY4 A;  2DHF A;  3GI2 A;  4M6L A;  1J3J A;  1U71 A;  3F0S X;  1ZDR A;  4QLG A;  3UM8 A;  3CL9 A;  2BLB A;  3QLR A;  1DYR A;  2LF1 A;  3F91 A;  4NX7 A;  2OBC A;  1E26 A;  1DR2 A;  3FQZ A;  1LUD A;  4KD7 A;  1DR5 A;  1M79 A;  3JWK A;  1S3U A;  4KFJ A;  4TU5 X;  2FZJ A;  2W9S A;  5HSU A;  3FL9 A;  4IXF X;  1AOE A;  3QLZ A;  3F8Z A;  1CD2 A;  1RF7 A;  3SA1 A;  3SRW X;  3M09 A;  3SR5 X;  2L28 A;  4KY4 A;  1RX3 A;  1DIU A;  4XT7 A;  3NXV A;  3ROA A;  4X5F A;  4X5G A;  5DFR A;  5JG0 X;  3F0U X;  3F8Y A;  3HJ3 A;  2ANQ A;  3EX8 A;  3RO9 A;  3OCH A;  1KMS A;  4RGC A;  1DYI A;  2W3V A;  3FRE X;  4M7U A;  5HF0 X;  4KM2 A;  4DFR A;  3S9U A;  4I13 A;  5HT5 A;  3QLY A;  3FRA X;  1RX7 A;  1YHO A;  4QJC A;  4DP3 A;  3NZ9 X;  4ELH A;  3FRD X;  1DG8 A;  1J3I A;  1CZ3 A;  4ELG A;  4XEC X;  2XW7 A;  3IRM A;  3NXO A;  3NXT A;  3QLW A;  3NXY A;  3KGY A;  3TQB A;  2W9G A;  1RG7 A;  1OHJ A;  3F0X X;  4KNE A;  4GH8 A;  3QL3 A;  5HUI A;  3FRB X;  3IRO A;  3FYW X;  3KJS A;  4G3M A;  3NXX A;  4OR7 A;  1PD8 A;  3SQY X;  3NZD A;  3L3R A;  1DLS A;  3UM5 A;  2GD9 A;  1RD7 A;  3CD2 A;  2BLA A;  4KAK A;  3ZPC A;  3S3V A;  1U70 A;  3TQA A;  1DR3 A;  3QLX A;  1DYH A;  5U27 A;  4ELE A;  4OSG A;  2ZZA A;  3ZPG A;  7DFR A;  1M78 A;  5HQY A;  3JTW A;  1BZF A;  1LY3 A;  4KJL A;  3FQF A;  1RX6 A;  2HXV A;  1DRA A;  1RA1 A;  4PSS A;  4ELF A;  3M08 A;  3TQ9 A;  4H98 A;  5CC9 A;  4Q0E A;  2D0K A;  1MVS A;  3QGT A;  4KY8 A;  3E0B A;  3TD8 A;  4XT4 A;  4XT5 A;  3DL6 A;  2W3A A;  4PTH A;  3N0H A;  3I3R A;  3FYV X;  1JOM A;  5HI6 A;  4XE6 X;  4XRB A;  5E8Q A;  2ITH A;  1DR4 A;  1D1G A;  1RA9 A;  3DG8 A;  4EIZ A;  4P3R A;  1RX9 A;  3SRQ X;  3JVX A;  1HFQ A;  2HM9 A;  3QYO A;  4IXE D;  1DAJ A;  3EEK A;  2BL9 A;  4CD2 A;  1RX4 A;  2W3M A;  1DR1 A;  3KY8 A;  3FQO A;  4Q67 A;  3D84 X;  4QJZ D;  4QHV A;  2KGK A;  3FQ0 A;  1BOZ A;  4KBN A;  1RH3 A;  1MVT A;  3IRN A;  3OAF A;  8DFR A;  1DDR A;  3SRU X;  1DRH A;  1OHK A;  4P66 A;  3NTZ A;  2W9T A;  1PDB A;  4PTJ A;  1RA3 A;  4EJ1 A;  1VJ3 A;  2CIG A;  4ECK A;  3FRF X;  4QLF A;  4M6K A;  3JSU A;  1RX2 A;  3EEM A;  1AO8 A;  3KFY A;  1DLR A;  4M7V A;  4P68 A;  2INQ A;  5CCC A;  4KJJ A;  1RA8 A;  3JWF A;  3DFR A;  4KL9 A;  5JA3 A;  1DRB A;  3NZA X;  4PST A;  4DPH A;  3S7A A;  3R33 A;  5ECX A;  3GYF A;  2W3W A;  1RX1 A;  3NZ6 X;  4FHB A;  3DAT A;  3NZB X;  1S3Y A;  3K74 A;  3SA2 A;  1DF7 A;  3Q1H A;  2P4G A;  3LG4 A;  4HOE A;  1DHF A;  2W9H A;  1KMV A;  3K45 A;  2G6V A;  3EEL A;  4ELB A;  1HFR A;  4M2X A;  1RA2 A;  4G95 A;  3KJR A;  3INV A;  4KEB A;  1KLK A;  2ANO A;  5HVB A;  4Q0D A;  3CSE A;  2CD2 A;  3VCO A;  1DHI A;  4LAG X;  5HPB A;  1RB3 A;  1HFP A;  1DR7 A;  4FGG A;  3SRS X;  3EEJ A;  2D5N A;  4M6J A;  3TQ8 A;  4PDJ A;  4I1N A;  3QG2 A;  3EIG A;  2OIP A;  5DXV A;  2C2S A;  4G8Z X;  4H97 A;  2W3B A;  1DYJ A;  3F0Q X;  1RE7 A;  1DDS A;  1DHJ A;  1M7A A;  3HBB A;  4DPD A;  3K2H A;  2FZI A;  1RX8 A;  1TDR A;  4LAE X;  4KM0 A;  1S3V A;  3FY8 X;  2C2T A;  5HQZ A;  1PD9 A;  3GHC A;  4LEK X;  3SAI A;  4IXG X;  5FDA A;  5HVE A;  2FZH A;  1RC4 A;  3D80 A;  3IX9 A;  3JW5 A;  4QI9 A;  4H96 A;  2B3Z A;  3NU0 A;  3FY9 X;  4QLE A;  4FGH A;  4P3Q A;  3JWC A;  3QL0 A;  4EIL A;  1RX5 A;  5HT4 A;  4DDR A;  4NX6 A;  4X5J A;  2H2Q A;  3FQV A;  3DAU A;  1AI9 A;  1S3W A;  2QK8 A;  3F0V X;  1DR6 A;  2O7P A;  1SEJ A;  1DIS A;  4PSY A;  5EAJ A;  1IA3 A;  5HF2 X;  3CLB A;  3RG9 A;  3DL5 A;  3FQC A;  1JUV A;  4Q6A A;  4KYA A;  3F0B X;  1J3K A;  1DG5 A;  4X5H A;  1IA4 A;  4KLX A;  3IA5 A;  2DRC A;  3SRR X;  3FL8 A;  3GHV A;  4HA7 A;  3JW3 A;  5HSR A;  6DFR A;  4H95 A;  1DRE A;  1RB2 A;  4XT8 A;  2HQP A;  1DG7 A;  1IA2 A;  5ECC A;  3UM6 A;  3SH2 A;  4HOF A;  3DRC A;  3K47 A;  1IA1 A;  4EIG A;  1JOL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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