2W3MA

Human dihydrofolate reductase complexed with nadph and folate
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate
rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords DIHYDROFOLATE REDUCTASE
total genus 48
structure length 186
sequence length 186
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2008-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 2w3mA00
3FQVA 3RG9A 3F91A 3SRRX 3F0XX 3CD2A 1M79A 2BLBA 3F0SX 4G3MA 3TQAA 4PSTA 1JUVA 4X5IA 3JW5A 4M6KA 5CC9A 3DFRA 3R33A 2P4GA 4NX6A 4KBNA 2HM9A 1YHOA 6DFRA 3Q1HA 2LF1A 1CD2A 3F0UX 3TQ9A 3QL0A 1RX5A 1RE7A 2W9GA 1DYHA 3S7AA 4H96A 3FYVX 1MVSA 1M78A 3QYOA 3NZDA 3DGAA 1DRAA 4ELFA 1RA2A 4KM2A 1DR5A 1RX7A 4H97A 3CL9A 1HFPA 3JSUA 3JW3A 3SRUX 2L28A 4FGHA 4ELEA 3EEJA 4DPHA 1IA4A 5HQYA 1VJ3A 4TU5X 2C2TA 3SRQX 1RC4A 4ELBA 4IXED 4LAGX 3E0BA 3GHVA 1DYIA 3QLYA 1RD7A 5U27A 1DISA 1DRBA 7DFRA 2QK8A 4KJKA 3S9UA 4XT6A 2ANQA 1DHFA 1RX1A 4OR7A 3GHCA 5HPBA 1DG8A 1OHJA 1LUDA 4QLGA 4M2XA 4Q0EA 3NTZA 4KLXA 4X5JA 3INVA 3K45A 4I1NA 1AOEA 2GD9A 3NXYA 4I13A 2ANOA 1S3WA 3FQCA 1IA2A 3ZPGA 1U71A 3D84X 3IROA 4M6JA 2KGKA 3KFYA 3RO9A 3M08A 3F0VX 3SRSX 1U72A 3N0HA 1RB2A 2ZZAA 4PTJA 5E8QA 3KJRA 4P68A 3IA4A 3ROAA 3CSEA 1S3UA 3SRWX 4QJCA 3DRCA 3SAIA 1RH3A 2W3MA 3DL5A 3DG8A 1DIUA 3NXOA 3GHWA 3JWFA 4PSYA 2W3VA 4XECX 3NXVA 1LY3A 1RA8A 1E26A 2HQPA 4EIZA 4M7VA 5HT4A 4NX7A 2H2QA 1RX3A 1RA9A 4PTHA 3FL9A 4KL9A 1CZ3A 4EILA 5HVBA 3I8AX 4KFJA 4P3QA 3JVXA 2ITHA 4DP3A 3NRRA 1RF7A 1KMSA 1BOZA 1MVTA 1HFRA 3QG2A 1LY4A 2D0KA 3UM5A 4KJLA 8DFRA 4HOFA 3UM8A 4CD2A 4Q67A 4FHBA 1DLSA 2FZJA 4RGCA 2CD2A 3FQ0A 1DR2A 1ZDRA 1RA1A 2W9TA 1DR1A 1DHIA 4HOEA 3L3RA 4DPDA 5DFRA 3NXRA 3GI2A 1RA3A 4X5HA 3FQZA 3VCOA 3F0QX 3IA5A 1RG7A 2XW7A 3NZBX 5EAJA 1RB3A 4XRBA 4KEBA 4G8ZX 3SA1A 2OIPA 3FYWX 3KGYA 2BLCA 5ECCA 1DR6A 3QFXA 2BLAA 3FRBX 2W3BA 1DAJA 2HXVA 4M6LA 3S3VA 3HBBA 2G6VA 4PSSA 3SGYA 3IRNA 5U26A 3FQOA 1S3YA 4OSGA 1RX4A 3QLZA 1JOLA 5HUIA 5HSUA 4Q6AA 1J3KA 3TQ8A 3FS6A 4XT4A 1DRFA 3UM6A 4X5FA 4M7UA 4IXGX 4ELHA 4QLEA 3K47A 3GYFA 3I3RA 3JWKA 3NZAX 5HQZA 1DF7A 2B3ZA 2BL9A 4LAEX 4KYAA 4QI9A 4DFRA 3SR5X 3QLXA 4X5GA 3SA2A 3KJSA 1DDSA 1AO8A 3NZCX 1IA3A 3SQYX 1DG7A 1RX2A 4H95A 4QJZD 3EEMA 4KY8A 1TDRA 3FRDX 4KD7A 4QHVA 1HFQA 3DAUA 4QLFA 2INQA 1IA1A 1DYRA 4IXFX 3QYLA 4KY4A 4XT7A 3FRAX 4KM0A 2D5NA 5CCCA 2DHFA 4XT5A 4KNEA 4P3RA 1PDBA 3FRFX 3ZPCA 4KAKA 1JOMA 3NXXA 4EJ1A 4Q0DA 2W3AA 2W3WA 1DLRA 1DDRA 3FY9X 4LEKX 3QL3A 5JA3A 1AI9A 5HI6A 3FREX 5HT5A 5HVEA 2OBCA 3OAFA 2DRCA 4GH8A 1DG5A 1PD9A 2FZHA 4EIGA 4LAHX 3KY8A 2O7PA 2CIGA 3SH2A 3OCHA 4KJJA 1S3VA 3JWCA 3QGTA 1VDRA 3FQFA 3EIGA 1QZFA 2W9SA 4ELGA 3NZ6X 4DDRA 1DHJA 4XT8A 3IX9A 4HOGA 1BZFA 3DATA 5ECXA 1D1GA 3JTWA 3CLBA 1DRHA 5JG0X 4PDJA 5FDAA 3F0BX 3DL6A 1OHKA 2C2SA 1RX9A 1U70A 3TQBA 3K2HA 1DR4A 4HA7A 4HA9A 1PD8A 3FL8A 3D80A 3NXTA 5HF2X 2W9HA 3K74A 3F8ZA 1DREA 3EELA 1DYJA 3HJ3A 1J3IA 1DR3A 3JWMA 5DXVA 1RX6A 5HF0X 1RX8A 3NZ9X 3F8YA 3LG4A 4XE6X 3EEKA 3EX8A 2JYBA 2AZNA 4FGGA 1KMVA 1M7AA 4H98A 4P66A 1SEJA 5HSRA 3FY8X 1DR7A 3TD8A 3M09A 4G95A 3NU0A 1J3JA 3QLRA 4ECKA 1KLKA 3IRMA 3QLWA 2FZIA 3QLSA
chains in the Genus database with same CATH superfamily
3FQVA 3RG9A 3F91A 3SRRX 3F0XX 3CD2A 1M79A 2BLBA 3F0SX 4G3MA 3TQAA 4PSTA 1JUVA 4X5IA 3JW5A 4M6KA 5CC9A 3DFRA 3R33A 2P4GA 4NX6A 4KBNA 2HM9A 1YHOA 6DFRA 3Q1HA 2LF1A 1CD2A 3F0UX 3TQ9A 3QL0A 1RX5A 1RE7A 2W9GA 1DYHA 3S7AA 4H96A 3FYVX 1MVSA 1M78A 3QYOA 3NZDA 3DGAA 1DRAA 4ELFA 1RA2A 4KM2A 1DR5A 1RX7A 4H97A 3CL9A 1HFPA 3JSUA 3JW3A 3SRUX 2L28A 4FGHA 4ELEA 3EEJA 4DPHA 1IA4A 5HQYA 1VJ3A 4TU5X 2C2TA 3SRQX 1RC4A 4ELBA 4IXED 4LAGX 3E0BA 3GHVA 1DYIA 3QLYA 1RD7A 5U27A 1DISA 1DRBA 7DFRA 2QK8A 4KJKA 3S9UA 4XT6A 2ANQA 1DHFA 1RX1A 4OR7A 3GHCA 5HPBA 1DG8A 1OHJA 1LUDA 4QLGA 4M2XA 4Q0EA 3NTZA 4KLXA 4X5JA 3INVA 3K45A 4I1NA 1AOEA 2GD9A 3NXYA 4I13A 2ANOA 1S3WA 3FQCA 1IA2A 3ZPGA 1U71A 3D84X 3IROA 4M6JA 2KGKA 3KFYA 3RO9A 3M08A 3F0VX 3SRSX 1U72A 3N0HA 1RB2A 2ZZAA 4PTJA 5E8QA 3KJRA 4P68A 3IA4A 3ROAA 3CSEA 1S3UA 3SRWX 4QJCA 3DRCA 3SAIA 1RH3A 2W3MA 3DL5A 3DG8A 1DIUA 3NXOA 3GHWA 3JWFA 4PSYA 2W3VA 4XECX 3NXVA 1LY3A 1RA8A 1E26A 2HQPA 4EIZA 4M7VA 5HT4A 4NX7A 2H2QA 1RX3A 1RA9A 4PTHA 3FL9A 4KL9A 1CZ3A 4EILA 5HVBA 3I8AX 4KFJA 4P3QA 3JVXA 2ITHA 4DP3A 3NRRA 1RF7A 1KMSA 1BOZA 1MVTA 1HFRA 3QG2A 1LY4A 2D0KA 3UM5A 4KJLA 8DFRA 4HOFA 3UM8A 4CD2A 4Q67A 4FHBA 1DLSA 2FZJA 4RGCA 2CD2A 3FQ0A 1DR2A 1ZDRA 1RA1A 2W9TA 1DR1A 1DHIA 4HOEA 3L3RA 4DPDA 5DFRA 3NXRA 3GI2A 1RA3A 4X5HA 3FQZA 3VCOA 3F0QX 3IA5A 1RG7A 2XW7A 3NZBX 5EAJA 1RB3A 4XRBA 4KEBA 4G8ZX 3SA1A 2OIPA 3FYWX 3KGYA 2BLCA 5ECCA 1DR6A 3QFXA 2BLAA 3FRBX 2W3BA 1DAJA 2HXVA 4M6LA 3S3VA 3HBBA 2G6VA 4PSSA 3SGYA 3IRNA 5U26A 3FQOA 1S3YA 4OSGA 1RX4A 3QLZA 1JOLA 5HUIA 5HSUA 4Q6AA 1J3KA 3TQ8A 3FS6A 4XT4A 1DRFA 3UM6A 4X5FA 4M7UA 4IXGX 4ELHA 4QLEA 3K47A 3GYFA 3I3RA 3JWKA 3NZAX 5HQZA 1DF7A 2B3ZA 2BL9A 4LAEX 4KYAA 4QI9A 4DFRA 3SR5X 3QLXA 4X5GA 3SA2A 3KJSA 1DDSA 1AO8A 3NZCX 1IA3A 3SQYX 1DG7A 1RX2A 4H95A 4QJZD 3EEMA 4KY8A 1TDRA 3FRDX 4KD7A 4QHVA 1HFQA 3DAUA 4QLFA 2INQA 1IA1A 1DYRA 4IXFX 3QYLA 4KY4A 4XT7A 3FRAX 4KM0A 2D5NA 5CCCA 2DHFA 4XT5A 4KNEA 4P3RA 1PDBA 3FRFX 3ZPCA 4KAKA 1JOMA 3NXXA 4EJ1A 4Q0DA 2W3AA 2W3WA 1DLRA 1DDRA 3FY9X 4LEKX 3QL3A 5JA3A 1AI9A 5HI6A 3FREX 5HT5A 5HVEA 2OBCA 3OAFA 2DRCA 4GH8A 1DG5A 1PD9A 2FZHA 4EIGA 4LAHX 3KY8A 2O7PA 2CIGA 3SH2A 3OCHA 4KJJA 1S3VA 3JWCA 3QGTA 1VDRA 3FQFA 3EIGA 1QZFA 2W9SA 4ELGA 3NZ6X 4DDRA 1DHJA 4XT8A 3IX9A 4HOGA 1BZFA 3DATA 5ECXA 1D1GA 3JTWA 3CLBA 1DRHA 5JG0X 4PDJA 5FDAA 3F0BX 3DL6A 1OHKA 2C2SA 1RX9A 1U70A 3TQBA 3K2HA 1DR4A 4HA7A 4HA9A 1PD8A 3FL8A 3D80A 3NXTA 5HF2X 2W9HA 3K74A 3F8ZA 1DREA 3EELA 1DYJA 3HJ3A 1J3IA 1DR3A 3JWMA 5DXVA 1RX6A 5HF0X 1RX8A 3NZ9X 3F8YA 3LG4A 4XE6X 3EEKA 3EX8A 2JYBA 2AZNA 4FGGA 1KMVA 1M7AA 4H98A 4P66A 1SEJA 5HSRA 3FY8X 1DR7A 3TD8A 3M09A 4G95A 3NU0A 1J3JA 3QLRA 4ECKA 1KLKA 3IRMA 3QLWA 2FZIA 3QLSA
chains in the Genus database with same CATH topology
3FQVA 3RG9A 3F91A 3SRRX 3F0XX 3CD2A 1M79A 2BLBA 3F0SX 4G3MA 3TQAA 4PSTA 1JUVA 4X5IA 3JW5A 4M6KA 5CC9A 3DFRA 3R33A 2P4GA 4NX6A 4KBNA 2HM9A 1YHOA 6DFRA 3Q1HA 2LF1A 1CD2A 3F0UX 3TQ9A 3QL0A 1RX5A 1RE7A 2W9GA 1DYHA 3S7AA 4H96A 3FYVX 1MVSA 1M78A 3QYOA 3NZDA 3DGAA 1DRAA 4ELFA 1RA2A 4KM2A 1DR5A 1RX7A 4H97A 3CL9A 1HFPA 3JSUA 3JW3A 3SRUX 2L28A 4FGHA 4ELEA 3EEJA 4DPHA 1IA4A 5HQYA 1VJ3A 4TU5X 2C2TA 3SRQX 1RC4A 4ELBA 4IXED 4LAGX 3E0BA 3GHVA 1DYIA 3QLYA 1RD7A 5U27A 1DISA 1DRBA 7DFRA 2QK8A 4KJKA 3S9UA 4XT6A 2ANQA 1DHFA 1RX1A 4OR7A 3GHCA 5HPBA 1DG8A 1OHJA 1LUDA 4QLGA 4M2XA 4Q0EA 3NTZA 4KLXA 4X5JA 3INVA 3K45A 4I1NA 1AOEA 2GD9A 3NXYA 4I13A 2ANOA 1S3WA 3FQCA 1IA2A 3ZPGA 1U71A 3D84X 3IROA 4M6JA 2KGKA 3KFYA 3RO9A 3M08A 3F0VX 3SRSX 1U72A 3N0HA 1RB2A 2ZZAA 4PTJA 5E8QA 3KJRA 4P68A 3IA4A 3ROAA 3CSEA 1S3UA 3SRWX 4QJCA 3DRCA 3SAIA 1RH3A 2W3MA 3DL5A 3DG8A 1DIUA 3NXOA 3GHWA 3JWFA 4PSYA 2W3VA 4XECX 3NXVA 1LY3A 1RA8A 1E26A 2HQPA 4EIZA 4M7VA 5HT4A 4NX7A 2H2QA 1RX3A 1RA9A 4PTHA 3FL9A 4KL9A 1CZ3A 4EILA 5HVBA 3I8AX 4KFJA 4P3QA 3JVXA 2ITHA 4DP3A 3NRRA 1RF7A 1KMSA 1BOZA 1MVTA 1HFRA 3QG2A 1LY4A 2D0KA 3UM5A 4KJLA 8DFRA 4HOFA 3UM8A 4CD2A 4Q67A 4FHBA 1DLSA 2FZJA 4RGCA 2CD2A 3FQ0A 1DR2A 1ZDRA 1RA1A 2W9TA 1DR1A 1DHIA 4HOEA 3L3RA 4DPDA 5DFRA 3NXRA 3GI2A 1RA3A 4X5HA 3FQZA 3VCOA 3F0QX 3IA5A 1RG7A 2XW7A 3NZBX 5EAJA 1RB3A 4XRBA 4KEBA 4G8ZX 3SA1A 2OIPA 3FYWX 3KGYA 2BLCA 5ECCA 1DR6A 3QFXA 2BLAA 3FRBX 2W3BA 1DAJA 2HXVA 4M6LA 3S3VA 3HBBA 2G6VA 4PSSA 3SGYA 3IRNA 5U26A 3FQOA 1S3YA 4OSGA 1RX4A 3QLZA 1JOLA 5HUIA 5HSUA 4Q6AA 1J3KA 3TQ8A 3FS6A 4XT4A 1DRFA 3UM6A 4X5FA 4M7UA 4IXGX 4ELHA 4QLEA 3K47A 3GYFA 3I3RA 3JWKA 3NZAX 5HQZA 1DF7A 2B3ZA 2BL9A 4LAEX 4KYAA 4QI9A 4DFRA 3SR5X 3QLXA 4X5GA 3SA2A 3KJSA 1DDSA 1AO8A 3NZCX 1IA3A 3SQYX 1DG7A 1RX2A 4H95A 4QJZD 3EEMA 4KY8A 1TDRA 3FRDX 4KD7A 4QHVA 1HFQA 3DAUA 4QLFA 2INQA 1IA1A 1DYRA 4IXFX 3QYLA 4KY4A 4XT7A 3FRAX 4KM0A 2D5NA 5CCCA 2DHFA 4XT5A 4KNEA 4P3RA 1PDBA 3FRFX 3ZPCA 4KAKA 1JOMA 3NXXA 4EJ1A 4Q0DA 2W3AA 2W3WA 1DLRA 1DDRA 3FY9X 4LEKX 3QL3A 5JA3A 1AI9A 5HI6A 3FREX 5HT5A 5HVEA 2OBCA 3OAFA 2DRCA 4GH8A 1DG5A 1PD9A 2FZHA 4EIGA 4LAHX 3KY8A 2O7PA 2CIGA 3SH2A 3OCHA 4KJJA 1S3VA 3JWCA 3QGTA 1VDRA 3FQFA 3EIGA 1QZFA 2W9SA 4ELGA 3NZ6X 4DDRA 1DHJA 4XT8A 3IX9A 4HOGA 1BZFA 3DATA 5ECXA 1D1GA 3JTWA 3CLBA 1DRHA 5JG0X 4PDJA 5FDAA 3F0BX 3DL6A 1OHKA 2C2SA 1RX9A 1U70A 3TQBA 3K2HA 1DR4A 4HA7A 4HA9A 1PD8A 3FL8A 3D80A 3NXTA 5HF2X 2W9HA 3K74A 3F8ZA 1DREA 3EELA 1DYJA 3HJ3A 1J3IA 1DR3A 3JWMA 5DXVA 1RX6A 5HF0X 1RX8A 3NZ9X 3F8YA 3LG4A 4XE6X 3EEKA 3EX8A 2JYBA 2AZNA 4FGGA 1KMVA 1M7AA 4H98A 4P66A 1SEJA 5HSRA 3FY8X 1DR7A 3TD8A 3M09A 4G95A 3NU0A 1J3JA 3QLRA 4ECKA 1KLKA 3IRMA 3QLWA 2FZIA 3QLSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FQV A;  3RG9 A;  3F91 A;  3SRR X;  3F0X X;  3CD2 A;  1M79 A;  2BLB A;  3F0S X;  4G3M A;  3TQA A;  4PST A;  1JUV A;  4X5I A;  3JW5 A;  4M6K A;  5CC9 A;  3DFR A;  3R33 A;  2P4G A;  4NX6 A;  4KBN A;  2HM9 A;  1YHO A;  6DFR A;  3Q1H A;  2LF1 A;  1CD2 A;  3F0U X;  3TQ9 A;  3QL0 A;  1RX5 A;  1RE7 A;  2W9G A;  1DYH A;  3S7A A;  4H96 A;  3FYV X;  1MVS A;  1M78 A;  3QYO A;  3NZD A;  3DGA A;  1DRA A;  4ELF A;  1RA2 A;  4KM2 A;  1DR5 A;  1RX7 A;  4H97 A;  3CL9 A;  1HFP A;  3JSU A;  3JW3 A;  3SRU X;  2L28 A;  4FGH A;  4ELE A;  3EEJ A;  4DPH A;  1IA4 A;  5HQY A;  1VJ3 A;  4TU5 X;  2C2T A;  3SRQ X;  1RC4 A;  4ELB A;  4IXE D;  4LAG X;  3E0B A;  3GHV A;  1DYI A;  3QLY A;  1RD7 A;  5U27 A;  1DIS A;  1DRB A;  7DFR A;  2QK8 A;  4KJK A;  3S9U A;  4XT6 A;  2ANQ A;  1DHF A;  1RX1 A;  4OR7 A;  3GHC A;  5HPB A;  1DG8 A;  1OHJ A;  1LUD A;  4QLG A;  4M2X A;  4Q0E A;  3NTZ A;  4KLX A;  4X5J A;  3INV A;  3K45 A;  4I1N A;  1AOE A;  2GD9 A;  3NXY A;  4I13 A;  2ANO A;  1S3W A;  3FQC A;  1IA2 A;  3ZPG A;  1U71 A;  3D84 X;  3IRO A;  4M6J A;  2KGK A;  3KFY A;  3RO9 A;  3M08 A;  3F0V X;  3SRS X;  1U72 A;  3N0H A;  1RB2 A;  2ZZA A;  4PTJ A;  5E8Q A;  3KJR A;  4P68 A;  3IA4 A;  3ROA A;  3CSE A;  1S3U A;  3SRW X;  4QJC A;  3DRC A;  3SAI A;  1RH3 A;  2W3M A;  3DL5 A;  3DG8 A;  1DIU A;  3NXO A;  3GHW A;  3JWF A;  4PSY A;  2W3V A;  4XEC X;  3NXV A;  1LY3 A;  1RA8 A;  1E26 A;  2HQP A;  4EIZ A;  4M7V A;  5HT4 A;  4NX7 A;  2H2Q A;  1RX3 A;  1RA9 A;  4PTH A;  3FL9 A;  4KL9 A;  1CZ3 A;  4EIL A;  5HVB A;  3I8A X;  4KFJ A;  4P3Q A;  3JVX A;  2ITH A;  4DP3 A;  3NRR A;  1RF7 A;  1KMS A;  1BOZ A;  1MVT A;  1HFR A;  3QG2 A;  1LY4 A;  2D0K A;  3UM5 A;  4KJL A;  8DFR A;  4HOF A;  3UM8 A;  4CD2 A;  4Q67 A;  4FHB A;  1DLS A;  2FZJ A;  4RGC A;  2CD2 A;  3FQ0 A;  1DR2 A;  1ZDR A;  1RA1 A;  2W9T A;  1DR1 A;  1DHI A;  4HOE A;  3L3R A;  4DPD A;  5DFR A;  3NXR A;  3GI2 A;  1RA3 A;  4X5H A;  3FQZ A;  3VCO A;  3F0Q X;  3IA5 A;  1RG7 A;  2XW7 A;  3NZB X;  5EAJ A;  1RB3 A;  4XRB A;  4KEB A;  4G8Z X;  3SA1 A;  2OIP A;  3FYW X;  3KGY A;  2BLC A;  5ECC A;  1DR6 A;  3QFX A;  2BLA A;  3FRB X;  2W3B A;  1DAJ A;  2HXV A;  4M6L A;  3S3V A;  3HBB A;  2G6V A;  4PSS A;  3SGY A;  3IRN A;  5U26 A;  3FQO A;  1S3Y A;  4OSG A;  1RX4 A;  3QLZ A;  1JOL A;  5HUI A;  5HSU A;  4Q6A A;  1J3K A;  3TQ8 A;  3FS6 A;  4XT4 A;  1DRF A;  3UM6 A;  4X5F A;  4M7U A;  4IXG X;  4ELH A;  4QLE A;  3K47 A;  3GYF A;  3I3R A;  3JWK A;  3NZA X;  5HQZ A;  1DF7 A;  2B3Z A;  2BL9 A;  4LAE X;  4KYA A;  4QI9 A;  4DFR A;  3SR5 X;  3QLX A;  4X5G A;  3SA2 A;  3KJS A;  1DDS A;  1AO8 A;  3NZC X;  1IA3 A;  3SQY X;  1DG7 A;  1RX2 A;  4H95 A;  4QJZ D;  3EEM A;  4KY8 A;  1TDR A;  3FRD X;  4KD7 A;  4QHV A;  1HFQ A;  3DAU A;  4QLF A;  2INQ A;  1IA1 A;  1DYR A;  4IXF X;  3QYL A;  4KY4 A;  4XT7 A;  3FRA X;  4KM0 A;  2D5N A;  5CCC A;  2DHF A;  4XT5 A;  4KNE A;  4P3R A;  1PDB A;  3FRF X;  3ZPC A;  4KAK A;  1JOM A;  3NXX A;  4EJ1 A;  4Q0D A;  2W3A A;  2W3W A;  1DLR A;  1DDR A;  3FY9 X;  4LEK X;  3QL3 A;  5JA3 A;  1AI9 A;  5HI6 A;  3FRE X;  5HT5 A;  5HVE A;  2OBC A;  3OAF A;  2DRC A;  4GH8 A;  1DG5 A;  1PD9 A;  2FZH A;  4EIG A;  4LAH X;  3KY8 A;  2O7P A;  2CIG A;  3SH2 A;  3OCH A;  4KJJ A;  1S3V A;  3JWC A;  3QGT A;  1VDR A;  3FQF A;  3EIG A;  1QZF A;  2W9S A;  4ELG A;  3NZ6 X;  4DDR A;  1DHJ A;  4XT8 A;  3IX9 A;  4HOG A;  1BZF A;  3DAT A;  5ECX A;  1D1G A;  3JTW A;  3CLB A;  1DRH A;  5JG0 X;  4PDJ A;  5FDA A;  3F0B X;  3DL6 A;  1OHK A;  2C2S A;  1RX9 A;  1U70 A;  3TQB A;  3K2H A;  1DR4 A;  4HA7 A;  4HA9 A;  1PD8 A;  3FL8 A;  3D80 A;  3NXT A;  5HF2 X;  2W9H A;  3K74 A;  3F8Z A;  1DRE A;  3EEL A;  1DYJ A;  3HJ3 A;  1J3I A;  1DR3 A;  3JWM A;  5DXV A;  1RX6 A;  5HF0 X;  1RX8 A;  3NZ9 X;  3F8Y A;  3LG4 A;  4XE6 X;  3EEK A;  3EX8 A;  2JYB A;  2AZN A;  4FGG A;  1KMV A;  1M7A A;  4H98 A;  4P66 A;  1SEJ A;  5HSR A;  3FY8 X;  1DR7 A;  3TD8 A;  3M09 A;  4G95 A;  3NU0 A;  1J3J A;  3QLR A;  4ECK A;  1KLK A;  3IRM A;  3QLW A;  2FZI A;  3QLS A; 
#chains in the Genus database with same CATH topology
 3FQV A;  3RG9 A;  3F91 A;  3SRR X;  3F0X X;  3CD2 A;  1M79 A;  2BLB A;  3F0S X;  4G3M A;  3TQA A;  4PST A;  1JUV A;  4X5I A;  3JW5 A;  4M6K A;  5CC9 A;  3DFR A;  3R33 A;  2P4G A;  4NX6 A;  4KBN A;  2HM9 A;  1YHO A;  6DFR A;  3Q1H A;  2LF1 A;  1CD2 A;  3F0U X;  3TQ9 A;  3QL0 A;  1RX5 A;  1RE7 A;  2W9G A;  1DYH A;  3S7A A;  4H96 A;  3FYV X;  1MVS A;  1M78 A;  3QYO A;  3NZD A;  3DGA A;  1DRA A;  4ELF A;  1RA2 A;  4KM2 A;  1DR5 A;  1RX7 A;  4H97 A;  3CL9 A;  1HFP A;  3JSU A;  3JW3 A;  3SRU X;  2L28 A;  4FGH A;  4ELE A;  3EEJ A;  4DPH A;  1IA4 A;  5HQY A;  1VJ3 A;  4TU5 X;  2C2T A;  3SRQ X;  1RC4 A;  4ELB A;  4IXE D;  4LAG X;  3E0B A;  3GHV A;  1DYI A;  3QLY A;  1RD7 A;  5U27 A;  1DIS A;  1DRB A;  7DFR A;  2QK8 A;  4KJK A;  3S9U A;  4XT6 A;  2ANQ A;  1DHF A;  1RX1 A;  4OR7 A;  3GHC A;  5HPB A;  1DG8 A;  1OHJ A;  1LUD A;  4QLG A;  4M2X A;  4Q0E A;  3NTZ A;  4KLX A;  4X5J A;  3INV A;  3K45 A;  4I1N A;  1AOE A;  2GD9 A;  3NXY A;  4I13 A;  2ANO A;  1S3W A;  3FQC A;  1IA2 A;  3ZPG A;  1U71 A;  3D84 X;  3IRO A;  4M6J A;  2KGK A;  3KFY A;  3RO9 A;  3M08 A;  3F0V X;  3SRS X;  1U72 A;  3N0H A;  1RB2 A;  2ZZA A;  4PTJ A;  5E8Q A;  3KJR A;  4P68 A;  3IA4 A;  3ROA A;  3CSE A;  1S3U A;  3SRW X;  4QJC A;  3DRC A;  3SAI A;  1RH3 A;  2W3M A;  3DL5 A;  3DG8 A;  1DIU A;  3NXO A;  3GHW A;  3JWF A;  4PSY A;  2W3V A;  4XEC X;  3NXV A;  1LY3 A;  1RA8 A;  1E26 A;  2HQP A;  4EIZ A;  4M7V A;  5HT4 A;  4NX7 A;  2H2Q A;  1RX3 A;  1RA9 A;  4PTH A;  3FL9 A;  4KL9 A;  1CZ3 A;  4EIL A;  5HVB A;  3I8A X;  4KFJ A;  4P3Q A;  3JVX A;  2ITH A;  4DP3 A;  3NRR A;  1RF7 A;  1KMS A;  1BOZ A;  1MVT A;  1HFR A;  3QG2 A;  1LY4 A;  2D0K A;  3UM5 A;  4KJL A;  8DFR A;  4HOF A;  3UM8 A;  4CD2 A;  4Q67 A;  4FHB A;  1DLS A;  2FZJ A;  4RGC A;  2CD2 A;  3FQ0 A;  1DR2 A;  1ZDR A;  1RA1 A;  2W9T A;  1DR1 A;  1DHI A;  4HOE A;  3L3R A;  4DPD A;  5DFR A;  3NXR A;  3GI2 A;  1RA3 A;  4X5H A;  3FQZ A;  3VCO A;  3F0Q X;  3IA5 A;  1RG7 A;  2XW7 A;  3NZB X;  5EAJ A;  1RB3 A;  4XRB A;  4KEB A;  4G8Z X;  3SA1 A;  2OIP A;  3FYW X;  3KGY A;  2BLC A;  5ECC A;  1DR6 A;  3QFX A;  2BLA A;  3FRB X;  2W3B A;  1DAJ A;  2HXV A;  4M6L A;  3S3V A;  3HBB A;  2G6V A;  4PSS A;  3SGY A;  3IRN A;  5U26 A;  3FQO A;  1S3Y A;  4OSG A;  1RX4 A;  3QLZ A;  1JOL A;  5HUI A;  5HSU A;  4Q6A A;  1J3K A;  3TQ8 A;  3FS6 A;  4XT4 A;  1DRF A;  3UM6 A;  4X5F A;  4M7U A;  4IXG X;  4ELH A;  4QLE A;  3K47 A;  3GYF A;  3I3R A;  3JWK A;  3NZA X;  5HQZ A;  1DF7 A;  2B3Z A;  2BL9 A;  4LAE X;  4KYA A;  4QI9 A;  4DFR A;  3SR5 X;  3QLX A;  4X5G A;  3SA2 A;  3KJS A;  1DDS A;  1AO8 A;  3NZC X;  1IA3 A;  3SQY X;  1DG7 A;  1RX2 A;  4H95 A;  4QJZ D;  3EEM A;  4KY8 A;  1TDR A;  3FRD X;  4KD7 A;  4QHV A;  1HFQ A;  3DAU A;  4QLF A;  2INQ A;  1IA1 A;  1DYR A;  4IXF X;  3QYL A;  4KY4 A;  4XT7 A;  3FRA X;  4KM0 A;  2D5N A;  5CCC A;  2DHF A;  4XT5 A;  4KNE A;  4P3R A;  1PDB A;  3FRF X;  3ZPC A;  4KAK A;  1JOM A;  3NXX A;  4EJ1 A;  4Q0D A;  2W3A A;  2W3W A;  1DLR A;  1DDR A;  3FY9 X;  4LEK X;  3QL3 A;  5JA3 A;  1AI9 A;  5HI6 A;  3FRE X;  5HT5 A;  5HVE A;  2OBC A;  3OAF A;  2DRC A;  4GH8 A;  1DG5 A;  1PD9 A;  2FZH A;  4EIG A;  4LAH X;  3KY8 A;  2O7P A;  2CIG A;  3SH2 A;  3OCH A;  4KJJ A;  1S3V A;  3JWC A;  3QGT A;  1VDR A;  3FQF A;  3EIG A;  1QZF A;  2W9S A;  4ELG A;  3NZ6 X;  4DDR A;  1DHJ A;  4XT8 A;  3IX9 A;  4HOG A;  1BZF A;  3DAT A;  5ECX A;  1D1G A;  3JTW A;  3CLB A;  1DRH A;  5JG0 X;  4PDJ A;  5FDA A;  3F0B X;  3DL6 A;  1OHK A;  2C2S A;  1RX9 A;  1U70 A;  3TQB A;  3K2H A;  1DR4 A;  4HA7 A;  4HA9 A;  1PD8 A;  3FL8 A;  3D80 A;  3NXT A;  5HF2 X;  2W9H A;  3K74 A;  3F8Z A;  1DRE A;  3EEL A;  1DYJ A;  3HJ3 A;  1J3I A;  1DR3 A;  3JWM A;  5DXV A;  1RX6 A;  5HF0 X;  1RX8 A;  3NZ9 X;  3F8Y A;  3LG4 A;  4XE6 X;  3EEK A;  3EX8 A;  2JYB A;  2AZN A;  4FGG A;  1KMV A;  1M7A A;  4H98 A;  4P66 A;  1SEJ A;  5HSR A;  3FY8 X;  1DR7 A;  3TD8 A;  3M09 A;  4G95 A;  3NU0 A;  1J3J A;  3QLR A;  4ECK A;  1KLK A;  3IRM A;  3QLW A;  2FZI A;  3QLS A; 
#chains in the Genus database with same CATH homology
 3FQV A;  3RG9 A;  3F91 A;  3SRR X;  3F0X X;  3CD2 A;  1M79 A;  2BLB A;  3F0S X;  4G3M A;  3TQA A;  4PST A;  1JUV A;  4X5I A;  3JW5 A;  4M6K A;  5CC9 A;  3DFR A;  3R33 A;  2P4G A;  4NX6 A;  4KBN A;  2HM9 A;  1YHO A;  6DFR A;  3Q1H A;  2LF1 A;  1CD2 A;  3F0U X;  3TQ9 A;  3QL0 A;  1RX5 A;  1RE7 A;  2W9G A;  1DYH A;  3S7A A;  4H96 A;  3FYV X;  1MVS A;  1M78 A;  3QYO A;  3NZD A;  3DGA A;  1DRA A;  4ELF A;  1RA2 A;  4KM2 A;  1DR5 A;  1RX7 A;  4H97 A;  3CL9 A;  1HFP A;  3JSU A;  3JW3 A;  3SRU X;  2L28 A;  4FGH A;  4ELE A;  3EEJ A;  4DPH A;  1IA4 A;  5HQY A;  1VJ3 A;  4TU5 X;  2C2T A;  3SRQ X;  1RC4 A;  4ELB A;  4IXE D;  4LAG X;  3E0B A;  3GHV A;  1DYI A;  3QLY A;  1RD7 A;  5U27 A;  1DIS A;  1DRB A;  7DFR A;  2QK8 A;  4KJK A;  3S9U A;  4XT6 A;  2ANQ A;  1DHF A;  1RX1 A;  4OR7 A;  3GHC A;  5HPB A;  1DG8 A;  1OHJ A;  1LUD A;  4QLG A;  4M2X A;  4Q0E A;  3NTZ A;  4KLX A;  4X5J A;  3INV A;  3K45 A;  4I1N A;  1AOE A;  2GD9 A;  3NXY A;  4I13 A;  2ANO A;  1S3W A;  3FQC A;  1IA2 A;  3ZPG A;  1U71 A;  3D84 X;  3IRO A;  4M6J A;  2KGK A;  3KFY A;  3RO9 A;  3M08 A;  3F0V X;  3SRS X;  1U72 A;  3N0H A;  1RB2 A;  2ZZA A;  4PTJ A;  5E8Q A;  3KJR A;  4P68 A;  3IA4 A;  3ROA A;  3CSE A;  1S3U A;  3SRW X;  4QJC A;  3DRC A;  3SAI A;  1RH3 A;  2W3M A;  3DL5 A;  3DG8 A;  1DIU A;  3NXO A;  3GHW A;  3JWF A;  4PSY A;  2W3V A;  4XEC X;  3NXV A;  1LY3 A;  1RA8 A;  1E26 A;  2HQP A;  4EIZ A;  4M7V A;  5HT4 A;  4NX7 A;  2H2Q A;  1RX3 A;  1RA9 A;  4PTH A;  3FL9 A;  4KL9 A;  1CZ3 A;  4EIL A;  5HVB A;  3I8A X;  4KFJ A;  4P3Q A;  3JVX A;  2ITH A;  4DP3 A;  3NRR A;  1RF7 A;  1KMS A;  1BOZ A;  1MVT A;  1HFR A;  3QG2 A;  1LY4 A;  2D0K A;  3UM5 A;  4KJL A;  8DFR A;  4HOF A;  3UM8 A;  4CD2 A;  4Q67 A;  4FHB A;  1DLS A;  2FZJ A;  4RGC A;  2CD2 A;  3FQ0 A;  1DR2 A;  1ZDR A;  1RA1 A;  2W9T A;  1DR1 A;  1DHI A;  4HOE A;  3L3R A;  4DPD A;  5DFR A;  3NXR A;  3GI2 A;  1RA3 A;  4X5H A;  3FQZ A;  3VCO A;  3F0Q X;  3IA5 A;  1RG7 A;  2XW7 A;  3NZB X;  5EAJ A;  1RB3 A;  4XRB A;  4KEB A;  4G8Z X;  3SA1 A;  2OIP A;  3FYW X;  3KGY A;  2BLC A;  5ECC A;  1DR6 A;  3QFX A;  2BLA A;  3FRB X;  2W3B A;  1DAJ A;  2HXV A;  4M6L A;  3S3V A;  3HBB A;  2G6V A;  4PSS A;  3SGY A;  3IRN A;  5U26 A;  3FQO A;  1S3Y A;  4OSG A;  1RX4 A;  3QLZ A;  1JOL A;  5HUI A;  5HSU A;  4Q6A A;  1J3K A;  3TQ8 A;  3FS6 A;  4XT4 A;  1DRF A;  3UM6 A;  4X5F A;  4M7U A;  4IXG X;  4ELH A;  4QLE A;  3K47 A;  3GYF A;  3I3R A;  3JWK A;  3NZA X;  5HQZ A;  1DF7 A;  2B3Z A;  2BL9 A;  4LAE X;  4KYA A;  4QI9 A;  4DFR A;  3SR5 X;  3QLX A;  4X5G A;  3SA2 A;  3KJS A;  1DDS A;  1AO8 A;  3NZC X;  1IA3 A;  3SQY X;  1DG7 A;  1RX2 A;  4H95 A;  4QJZ D;  3EEM A;  4KY8 A;  1TDR A;  3FRD X;  4KD7 A;  4QHV A;  1HFQ A;  3DAU A;  4QLF A;  2INQ A;  1IA1 A;  1DYR A;  4IXF X;  3QYL A;  4KY4 A;  4XT7 A;  3FRA X;  4KM0 A;  2D5N A;  5CCC A;  2DHF A;  4XT5 A;  4KNE A;  4P3R A;  1PDB A;  3FRF X;  3ZPC A;  4KAK A;  1JOM A;  3NXX A;  4EJ1 A;  4Q0D A;  2W3A A;  2W3W A;  1DLR A;  1DDR A;  3FY9 X;  4LEK X;  3QL3 A;  5JA3 A;  1AI9 A;  5HI6 A;  3FRE X;  5HT5 A;  5HVE A;  2OBC A;  3OAF A;  2DRC A;  4GH8 A;  1DG5 A;  1PD9 A;  2FZH A;  4EIG A;  4LAH X;  3KY8 A;  2O7P A;  2CIG A;  3SH2 A;  3OCH A;  4KJJ A;  1S3V A;  3JWC A;  3QGT A;  1VDR A;  3FQF A;  3EIG A;  1QZF A;  2W9S A;  4ELG A;  3NZ6 X;  4DDR A;  1DHJ A;  4XT8 A;  3IX9 A;  4HOG A;  1BZF A;  3DAT A;  5ECX A;  1D1G A;  3JTW A;  3CLB A;  1DRH A;  5JG0 X;  4PDJ A;  5FDA A;  3F0B X;  3DL6 A;  1OHK A;  2C2S A;  1RX9 A;  1U70 A;  3TQB A;  3K2H A;  1DR4 A;  4HA7 A;  4HA9 A;  1PD8 A;  3FL8 A;  3D80 A;  3NXT A;  5HF2 X;  2W9H A;  3K74 A;  3F8Z A;  1DRE A;  3EEL A;  1DYJ A;  3HJ3 A;  1J3I A;  1DR3 A;  3JWM A;  5DXV A;  1RX6 A;  5HF0 X;  1RX8 A;  3NZ9 X;  3F8Y A;  3LG4 A;  4XE6 X;  3EEK A;  3EX8 A;  2JYB A;  2AZN A;  4FGG A;  1KMV A;  1M7A A;  4H98 A;  4P66 A;  1SEJ A;  5HSR A;  3FY8 X;  1DR7 A;  3TD8 A;  3M09 A;  4G95 A;  3NU0 A;  1J3J A;  3QLR A;  4ECK A;  1KLK A;  3IRM A;  3QLW A;  2FZI A;  3QLS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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