3DG8A

Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf670, nadph, and dump
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
231
structure length
221
Chain Sequence
MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCISLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETKKLQNVVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFILGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.
pubmed doi rcsb
molecule tags Oxidoreductase, transferase
source organism Plasmodium falciparum
molecule keywords Bifunctional dihydrofolate reductase-thymidylate synthase
total genus 58
structure length 221
sequence length 231
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2008-06-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3dg8A00
3FYVX 1JOMA 3DGAA 3QFXA 4XT5A 4KLXA 1DISA 3UM5A 5HUIA 2W3BA 3ZPGA 3NZDA 3S7AA 3DATA 1HFRA 1RX2A 3QLXA 3SQYX 1RX6A 1DR6A 3F0XX 1QZFA 4KM2A 3TD8A 4M7UA 1DR2A 1RB2A 3E0BA 1DR3A 4QJCA 4KJKA 3FL9A 3FREX 3QLRA 4HOEA 1DHFA 1VJ3A 1DLRA 3SRQX 3NRRA 3F0SX 5HSRA 5HVEA 1RX7A 5HT5A 3NXYA 3K74A 1HFPA 3FRDX 2QK8A 3JW5A 3JWCA 3I8AX 4Q67A 3FQOA 3NXRA 5HQZA 2FZHA 1RX4A 1DR1A 1RA1A 5HSUA 1PD8A 3VCOA 3NZBX 4QHVA 4XRBA 3DL6A 3NZ6X 3QGTA 3FQVA 3NZCX 3KJSA 3CL9A 3K2HA 4G8ZX 4QLGA 1KMSA 3D80A 1S3YA 4ELBA 4QLEA 1AO8A 3QYLA 1CD2A 5U26A 3FYWX 1BOZA 2G6VA 1S3WA 4ELFA 4I13A 4PTHA 2W9GA 4XECX 5JA3A 1LY4A 5E8QA 4DDRA 3SR5X 1IA4A 3FL8A 2LF1A 3I3RA 1PDBA 2KGKA 3IX9A 3CSEA 3IRMA 3FRAX 8DFRA 4Q6AA 4X5GA 4OSGA 1RX9A 4KM0A 1AOEA 3GHCA 2AZNA 3FQFA 5HI6A 1RG7A 3NXTA 5DFRA 3R33A 1KLKA 3TQBA 1U70A 3RO9A 3HBBA 1DG8A 4P68A 3EEJA 3K47A 3FQ0A 1D1GA 1OHJA 2W3WA 3SA2A 3JWMA 1CZ3A 3F0QX 3JWFA 3QYOA 4NX7A 4OR7A 3TQ8A 2HQPA 2HXVA 4HOFA 4X5IA 3DL5A 3QLWA 1IA3A 3QLYA 2B3ZA 4H97A 1KMVA 1DYHA 4LAGX 4KNEA 3NTZA 2L28A 2HM9A 1DR4A 1RX1A 4Q0DA 1PD9A 1ZDRA 4H98A 1DYRA 3SAIA 4QJZD 3KGYA 4KJJA 3D84X 4H95A 4RGCA 2C2TA 1LY3A 3KFYA 1J3KA 3DG8A 5HVBA 3GHVA 5HQYA 3QLSA 1RX3A 1DREA 4XT8A 1S3UA 5DXVA 1DIUA 1S3VA 2O7PA 4FHBA 4QI9A 4DPDA 3FS6A 1DHIA 1DRBA 4CD2A 5U27A 1MVSA 2ANOA 5ECXA 4P3RA 1U71A 3INVA 1IA2A 2OBCA 3JSUA 1RA3A 4KD7A 3K45A 2D0KA 3M09A 1RA9A 4XE6X 2DRCA 4P3QA 1DYJA 3OCHA 3FRBX 4I1NA 3QL3A 4XT6A 3DFRA 1LUDA 3ROAA 1BZFA 4KBNA 3SRWX 1DG5A 3UM8A 4KL9A 2GD9A 3N0HA 2JYBA 3LG4A 4GH8A 3CD2A 1DG7A 3TQAA 3FQCA 3GHWA 3S3VA 3JW3A 1DF7A 4KY8A 2ANQA 2W3MA 3FRFX 4PSTA 5CC9A 1RC4A 4M6JA 4P66A 4X5HA 3NXOA 4KY4A 5HT4A 4FGHA 4FGGA 3NZ9X 2BLBA 4M2XA 2W9TA 1VDRA 4NX6A 3SRUX 3GYFA 2W9SA 4LAHX 4DPHA 1DR7A 3EEMA 1DR5A 1RX8A 6DFRA 3TQ9A 3JTWA 4EJ1A 3DRCA 1E26A 3IA4A 3GI2A 4IXFX 1DDRA 4Q0EA 1M7AA 3NXXA 4DP3A 3EIGA 4HA9A 3QLZA 3QL0A 2C2SA 3FY8X 3HJ3A 3SRSX 2H2QA 3SA1A 4DFRA 1J3IA 3OAFA 1DRFA 2ITHA 1DAJA 4ECKA 3F0UX 1YHOA 4H96A 2BLCA 1MVTA 4G3MA 2INQA 4HA7A 4HOGA 4QLFA 3ZPCA 2FZJA 3SGYA 3JWKA 4PSYA 4KYAA 3S9UA 3CLBA 4IXGX 3IA5A 2OIPA 4X5FA 3QG2A 4TU5X 3F8ZA 5FDAA 3M08A 4PSSA 1TDRA 5ECCA 5HPBA 4KJLA 4G95A 2BLAA 1DDSA 2FZIA 4EIGA 3L3RA 2CD2A 1M78A 3EEKA 4IXED 1RE7A 4XT4A 1DYIA 3RG9A 1RA8A 4PDJA 2BL9A 4X5JA 1HFQA 4M7VA 4PTJA 1DLSA 3FY9X 3FQZA 3SRRX 1RF7A 3IRNA 4LEKX 1OHKA 2DHFA 1RX5A 1RH3A 1DRAA 1DRHA 1U72A 3EX8A 4KEBA 3NZAX 7DFRA 4ELHA 1AI9A 4EIZA 2P4GA 3KJRA 2W3AA 1J3JA 1RA2A 2D5NA 4LAEX 3F0VX 4ELEA 1RD7A 4XT7A 3SH2A 2W3VA 5JG0X 1JOLA 1IA1A 4ELGA 2CIGA 2XW7A 3NXVA 3F8YA 1M79A 2W9HA 5HF0X 1SEJA 5CCCA 3F91A 3KY8A 1DHJA 3IROA 1JUVA 1RB3A 3UM6A 3EELA 3F0BX 3Q1HA 3JVXA 4EILA 4KFJA 4M6LA 3DAUA 5EAJA 5HF2X 4KAKA 4M6KA 3NU0A 2ZZAA
chains in the Genus database with same CATH superfamily
3FYVX 1JOMA 3DGAA 3QFXA 4XT5A 4KLXA 1DISA 3UM5A 5HUIA 2W3BA 3ZPGA 3NZDA 3S7AA 3DATA 1HFRA 1RX2A 3QLXA 3SQYX 1RX6A 1DR6A 3F0XX 1QZFA 4KM2A 3TD8A 4M7UA 1DR2A 1RB2A 3E0BA 1DR3A 4QJCA 4KJKA 3FL9A 3FREX 3QLRA 4HOEA 1DHFA 1VJ3A 1DLRA 3SRQX 3NRRA 3F0SX 5HSRA 5HVEA 1RX7A 5HT5A 3NXYA 3K74A 1HFPA 3FRDX 2QK8A 3JW5A 3JWCA 3I8AX 4Q67A 3FQOA 3NXRA 5HQZA 2FZHA 1RX4A 1DR1A 1RA1A 5HSUA 1PD8A 3VCOA 3NZBX 4QHVA 4XRBA 3DL6A 3NZ6X 3QGTA 3FQVA 3NZCX 3KJSA 3CL9A 3K2HA 4G8ZX 4QLGA 1KMSA 3D80A 1S3YA 4ELBA 4QLEA 1AO8A 3QYLA 1CD2A 5U26A 3FYWX 1BOZA 2G6VA 1S3WA 4ELFA 4I13A 4PTHA 2W9GA 4XECX 5JA3A 1LY4A 5E8QA 4DDRA 3SR5X 1IA4A 3FL8A 2LF1A 3I3RA 1PDBA 2KGKA 3IX9A 3CSEA 3IRMA 3FRAX 8DFRA 4Q6AA 4X5GA 4OSGA 1RX9A 4KM0A 1AOEA 3GHCA 2AZNA 3FQFA 5HI6A 1RG7A 3NXTA 5DFRA 3R33A 1KLKA 3TQBA 1U70A 3RO9A 3HBBA 1DG8A 4P68A 3EEJA 3K47A 3FQ0A 1D1GA 1OHJA 2W3WA 3SA2A 3JWMA 1CZ3A 3F0QX 3JWFA 3QYOA 4NX7A 4OR7A 3TQ8A 2HQPA 2HXVA 4HOFA 4X5IA 3DL5A 3QLWA 1IA3A 3QLYA 2B3ZA 4H97A 1KMVA 1DYHA 4LAGX 4KNEA 3NTZA 2L28A 2HM9A 1DR4A 1RX1A 4Q0DA 1PD9A 1ZDRA 4H98A 1DYRA 3SAIA 4QJZD 3KGYA 4KJJA 3D84X 4H95A 4RGCA 2C2TA 1LY3A 3KFYA 1J3KA 3DG8A 5HVBA 3GHVA 5HQYA 3QLSA 1RX3A 1DREA 4XT8A 1S3UA 5DXVA 1DIUA 1S3VA 2O7PA 4FHBA 4QI9A 4DPDA 3FS6A 1DHIA 1DRBA 4CD2A 5U27A 1MVSA 2ANOA 5ECXA 4P3RA 1U71A 3INVA 1IA2A 2OBCA 3JSUA 1RA3A 4KD7A 3K45A 2D0KA 3M09A 1RA9A 4XE6X 2DRCA 4P3QA 1DYJA 3OCHA 3FRBX 4I1NA 3QL3A 4XT6A 3DFRA 1LUDA 3ROAA 1BZFA 4KBNA 3SRWX 1DG5A 3UM8A 4KL9A 2GD9A 3N0HA 2JYBA 3LG4A 4GH8A 3CD2A 1DG7A 3TQAA 3FQCA 3GHWA 3S3VA 3JW3A 1DF7A 4KY8A 2ANQA 2W3MA 3FRFX 4PSTA 5CC9A 1RC4A 4M6JA 4P66A 4X5HA 3NXOA 4KY4A 5HT4A 4FGHA 4FGGA 3NZ9X 2BLBA 4M2XA 2W9TA 1VDRA 4NX6A 3SRUX 3GYFA 2W9SA 4LAHX 4DPHA 1DR7A 3EEMA 1DR5A 1RX8A 6DFRA 3TQ9A 3JTWA 4EJ1A 3DRCA 1E26A 3IA4A 3GI2A 4IXFX 1DDRA 4Q0EA 1M7AA 3NXXA 4DP3A 3EIGA 4HA9A 3QLZA 3QL0A 2C2SA 3FY8X 3HJ3A 3SRSX 2H2QA 3SA1A 4DFRA 1J3IA 3OAFA 1DRFA 2ITHA 1DAJA 4ECKA 3F0UX 1YHOA 4H96A 2BLCA 1MVTA 4G3MA 2INQA 4HA7A 4HOGA 4QLFA 3ZPCA 2FZJA 3SGYA 3JWKA 4PSYA 4KYAA 3S9UA 3CLBA 4IXGX 3IA5A 2OIPA 4X5FA 3QG2A 4TU5X 3F8ZA 5FDAA 3M08A 4PSSA 1TDRA 5ECCA 5HPBA 4KJLA 4G95A 2BLAA 1DDSA 2FZIA 4EIGA 3L3RA 2CD2A 1M78A 3EEKA 4IXED 1RE7A 4XT4A 1DYIA 3RG9A 1RA8A 4PDJA 2BL9A 4X5JA 1HFQA 4M7VA 4PTJA 1DLSA 3FY9X 3FQZA 3SRRX 1RF7A 3IRNA 4LEKX 1OHKA 2DHFA 1RX5A 1RH3A 1DRAA 1DRHA 1U72A 3EX8A 4KEBA 3NZAX 7DFRA 4ELHA 1AI9A 4EIZA 2P4GA 3KJRA 2W3AA 1J3JA 1RA2A 2D5NA 4LAEX 3F0VX 4ELEA 1RD7A 4XT7A 3SH2A 2W3VA 5JG0X 1JOLA 1IA1A 4ELGA 2CIGA 2XW7A 3NXVA 3F8YA 1M79A 2W9HA 5HF0X 1SEJA 5CCCA 3F91A 3KY8A 1DHJA 3IROA 1JUVA 1RB3A 3UM6A 3EELA 3F0BX 3Q1HA 3JVXA 4EILA 4KFJA 4M6LA 3DAUA 5EAJA 5HF2X 4KAKA 4M6KA 3NU0A 2ZZAA
chains in the Genus database with same CATH topology
3FYVX 1JOMA 3DGAA 3QFXA 4XT5A 4KLXA 1DISA 3UM5A 5HUIA 2W3BA 3ZPGA 3NZDA 3S7AA 3DATA 1HFRA 1RX2A 3QLXA 3SQYX 1RX6A 1DR6A 3F0XX 1QZFA 4KM2A 3TD8A 4M7UA 1DR2A 1RB2A 3E0BA 1DR3A 4QJCA 4KJKA 3FL9A 3FREX 3QLRA 4HOEA 1DHFA 1VJ3A 1DLRA 3SRQX 3NRRA 3F0SX 5HSRA 5HVEA 1RX7A 5HT5A 3NXYA 3K74A 1HFPA 3FRDX 2QK8A 3JW5A 3JWCA 3I8AX 4Q67A 3FQOA 3NXRA 5HQZA 2FZHA 1RX4A 1DR1A 1RA1A 5HSUA 1PD8A 3VCOA 3NZBX 4QHVA 4XRBA 3DL6A 3NZ6X 3QGTA 3FQVA 3NZCX 3KJSA 3CL9A 3K2HA 4G8ZX 4QLGA 1KMSA 3D80A 1S3YA 4ELBA 4QLEA 1AO8A 3QYLA 1CD2A 5U26A 3FYWX 1BOZA 2G6VA 1S3WA 4ELFA 4I13A 4PTHA 2W9GA 4XECX 5JA3A 1LY4A 5E8QA 4DDRA 3SR5X 1IA4A 3FL8A 2LF1A 3I3RA 1PDBA 2KGKA 3IX9A 3CSEA 3IRMA 3FRAX 8DFRA 4Q6AA 4X5GA 4OSGA 1RX9A 4KM0A 1AOEA 3GHCA 2AZNA 3FQFA 5HI6A 1RG7A 3NXTA 5DFRA 3R33A 1KLKA 3TQBA 1U70A 3RO9A 3HBBA 1DG8A 4P68A 3EEJA 3K47A 3FQ0A 1D1GA 1OHJA 2W3WA 3SA2A 3JWMA 1CZ3A 3F0QX 3JWFA 3QYOA 4NX7A 4OR7A 3TQ8A 2HQPA 2HXVA 4HOFA 4X5IA 3DL5A 3QLWA 1IA3A 3QLYA 2B3ZA 4H97A 1KMVA 1DYHA 4LAGX 4KNEA 3NTZA 2L28A 2HM9A 1DR4A 1RX1A 4Q0DA 1PD9A 1ZDRA 4H98A 1DYRA 3SAIA 4QJZD 3KGYA 4KJJA 3D84X 4H95A 4RGCA 2C2TA 1LY3A 3KFYA 1J3KA 3DG8A 5HVBA 3GHVA 5HQYA 3QLSA 1RX3A 1DREA 4XT8A 1S3UA 5DXVA 1DIUA 1S3VA 2O7PA 4FHBA 4QI9A 4DPDA 3FS6A 1DHIA 1DRBA 4CD2A 5U27A 1MVSA 2ANOA 5ECXA 4P3RA 1U71A 3INVA 1IA2A 2OBCA 3JSUA 1RA3A 4KD7A 3K45A 2D0KA 3M09A 1RA9A 4XE6X 2DRCA 4P3QA 1DYJA 3OCHA 3FRBX 4I1NA 3QL3A 4XT6A 3DFRA 1LUDA 3ROAA 1BZFA 4KBNA 3SRWX 1DG5A 3UM8A 4KL9A 2GD9A 3N0HA 2JYBA 3LG4A 4GH8A 3CD2A 1DG7A 3TQAA 3FQCA 3GHWA 3S3VA 3JW3A 1DF7A 4KY8A 2ANQA 2W3MA 3FRFX 4PSTA 5CC9A 1RC4A 4M6JA 4P66A 4X5HA 3NXOA 4KY4A 5HT4A 4FGHA 4FGGA 3NZ9X 2BLBA 4M2XA 2W9TA 1VDRA 4NX6A 3SRUX 3GYFA 2W9SA 4LAHX 4DPHA 1DR7A 3EEMA 1DR5A 1RX8A 6DFRA 3TQ9A 3JTWA 4EJ1A 3DRCA 1E26A 3IA4A 3GI2A 4IXFX 1DDRA 4Q0EA 1M7AA 3NXXA 4DP3A 3EIGA 4HA9A 3QLZA 3QL0A 2C2SA 3FY8X 3HJ3A 3SRSX 2H2QA 3SA1A 4DFRA 1J3IA 3OAFA 1DRFA 2ITHA 1DAJA 4ECKA 3F0UX 1YHOA 4H96A 2BLCA 1MVTA 4G3MA 2INQA 4HA7A 4HOGA 4QLFA 3ZPCA 2FZJA 3SGYA 3JWKA 4PSYA 4KYAA 3S9UA 3CLBA 4IXGX 3IA5A 2OIPA 4X5FA 3QG2A 4TU5X 3F8ZA 5FDAA 3M08A 4PSSA 1TDRA 5ECCA 5HPBA 4KJLA 4G95A 2BLAA 1DDSA 2FZIA 4EIGA 3L3RA 2CD2A 1M78A 3EEKA 4IXED 1RE7A 4XT4A 1DYIA 3RG9A 1RA8A 4PDJA 2BL9A 4X5JA 1HFQA 4M7VA 4PTJA 1DLSA 3FY9X 3FQZA 3SRRX 1RF7A 3IRNA 4LEKX 1OHKA 2DHFA 1RX5A 1RH3A 1DRAA 1DRHA 1U72A 3EX8A 4KEBA 3NZAX 7DFRA 4ELHA 1AI9A 4EIZA 2P4GA 3KJRA 2W3AA 1J3JA 1RA2A 2D5NA 4LAEX 3F0VX 4ELEA 1RD7A 4XT7A 3SH2A 2W3VA 5JG0X 1JOLA 1IA1A 4ELGA 2CIGA 2XW7A 3NXVA 3F8YA 1M79A 2W9HA 5HF0X 1SEJA 5CCCA 3F91A 3KY8A 1DHJA 3IROA 1JUVA 1RB3A 3UM6A 3EELA 3F0BX 3Q1HA 3JVXA 4EILA 4KFJA 4M6LA 3DAUA 5EAJA 5HF2X 4KAKA 4M6KA 3NU0A 2ZZAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FYV X;  1JOM A;  3DGA A;  3QFX A;  4XT5 A;  4KLX A;  1DIS A;  3UM5 A;  5HUI A;  2W3B A;  3ZPG A;  3NZD A;  3S7A A;  3DAT A;  1HFR A;  1RX2 A;  3QLX A;  3SQY X;  1RX6 A;  1DR6 A;  3F0X X;  1QZF A;  4KM2 A;  3TD8 A;  4M7U A;  1DR2 A;  1RB2 A;  3E0B A;  1DR3 A;  4QJC A;  4KJK A;  3FL9 A;  3FRE X;  3QLR A;  4HOE A;  1DHF A;  1VJ3 A;  1DLR A;  3SRQ X;  3NRR A;  3F0S X;  5HSR A;  5HVE A;  1RX7 A;  5HT5 A;  3NXY A;  3K74 A;  1HFP A;  3FRD X;  2QK8 A;  3JW5 A;  3JWC A;  3I8A X;  4Q67 A;  3FQO A;  3NXR A;  5HQZ A;  2FZH A;  1RX4 A;  1DR1 A;  1RA1 A;  5HSU A;  1PD8 A;  3VCO A;  3NZB X;  4QHV A;  4XRB A;  3DL6 A;  3NZ6 X;  3QGT A;  3FQV A;  3NZC X;  3KJS A;  3CL9 A;  3K2H A;  4G8Z X;  4QLG A;  1KMS A;  3D80 A;  1S3Y A;  4ELB A;  4QLE A;  1AO8 A;  3QYL A;  1CD2 A;  5U26 A;  3FYW X;  1BOZ A;  2G6V A;  1S3W A;  4ELF A;  4I13 A;  4PTH A;  2W9G A;  4XEC X;  5JA3 A;  1LY4 A;  5E8Q A;  4DDR A;  3SR5 X;  1IA4 A;  3FL8 A;  2LF1 A;  3I3R A;  1PDB A;  2KGK A;  3IX9 A;  3CSE A;  3IRM A;  3FRA X;  8DFR A;  4Q6A A;  4X5G A;  4OSG A;  1RX9 A;  4KM0 A;  1AOE A;  3GHC A;  2AZN A;  3FQF A;  5HI6 A;  1RG7 A;  3NXT A;  5DFR A;  3R33 A;  1KLK A;  3TQB A;  1U70 A;  3RO9 A;  3HBB A;  1DG8 A;  4P68 A;  3EEJ A;  3K47 A;  3FQ0 A;  1D1G A;  1OHJ A;  2W3W A;  3SA2 A;  3JWM A;  1CZ3 A;  3F0Q X;  3JWF A;  3QYO A;  4NX7 A;  4OR7 A;  3TQ8 A;  2HQP A;  2HXV A;  4HOF A;  4X5I A;  3DL5 A;  3QLW A;  1IA3 A;  3QLY A;  2B3Z A;  4H97 A;  1KMV A;  1DYH A;  4LAG X;  4KNE A;  3NTZ A;  2L28 A;  2HM9 A;  1DR4 A;  1RX1 A;  4Q0D A;  1PD9 A;  1ZDR A;  4H98 A;  1DYR A;  3SAI A;  4QJZ D;  3KGY A;  4KJJ A;  3D84 X;  4H95 A;  4RGC A;  2C2T A;  1LY3 A;  3KFY A;  1J3K A;  3DG8 A;  5HVB A;  3GHV A;  5HQY A;  3QLS A;  1RX3 A;  1DRE A;  4XT8 A;  1S3U A;  5DXV A;  1DIU A;  1S3V A;  2O7P A;  4FHB A;  4QI9 A;  4DPD A;  3FS6 A;  1DHI A;  1DRB A;  4CD2 A;  5U27 A;  1MVS A;  2ANO A;  5ECX A;  4P3R A;  1U71 A;  3INV A;  1IA2 A;  2OBC A;  3JSU A;  1RA3 A;  4KD7 A;  3K45 A;  2D0K A;  3M09 A;  1RA9 A;  4XE6 X;  2DRC A;  4P3Q A;  1DYJ A;  3OCH A;  3FRB X;  4I1N A;  3QL3 A;  4XT6 A;  3DFR A;  1LUD A;  3ROA A;  1BZF A;  4KBN A;  3SRW X;  1DG5 A;  3UM8 A;  4KL9 A;  2GD9 A;  3N0H A;  2JYB A;  3LG4 A;  4GH8 A;  3CD2 A;  1DG7 A;  3TQA A;  3FQC A;  3GHW A;  3S3V A;  3JW3 A;  1DF7 A;  4KY8 A;  2ANQ A;  2W3M A;  3FRF X;  4PST A;  5CC9 A;  1RC4 A;  4M6J A;  4P66 A;  4X5H A;  3NXO A;  4KY4 A;  5HT4 A;  4FGH A;  4FGG A;  3NZ9 X;  2BLB A;  4M2X A;  2W9T A;  1VDR A;  4NX6 A;  3SRU X;  3GYF A;  2W9S A;  4LAH X;  4DPH A;  1DR7 A;  3EEM A;  1DR5 A;  1RX8 A;  6DFR A;  3TQ9 A;  3JTW A;  4EJ1 A;  3DRC A;  1E26 A;  3IA4 A;  3GI2 A;  4IXF X;  1DDR A;  4Q0E A;  1M7A A;  3NXX A;  4DP3 A;  3EIG A;  4HA9 A;  3QLZ A;  3QL0 A;  2C2S A;  3FY8 X;  3HJ3 A;  3SRS X;  2H2Q A;  3SA1 A;  4DFR A;  1J3I A;  3OAF A;  1DRF A;  2ITH A;  1DAJ A;  4ECK A;  3F0U X;  1YHO A;  4H96 A;  2BLC A;  1MVT A;  4G3M A;  2INQ A;  4HA7 A;  4HOG A;  4QLF A;  3ZPC A;  2FZJ A;  3SGY A;  3JWK A;  4PSY A;  4KYA A;  3S9U A;  3CLB A;  4IXG X;  3IA5 A;  2OIP A;  4X5F A;  3QG2 A;  4TU5 X;  3F8Z A;  5FDA A;  3M08 A;  4PSS A;  1TDR A;  5ECC A;  5HPB A;  4KJL A;  4G95 A;  2BLA A;  1DDS A;  2FZI A;  4EIG A;  3L3R A;  2CD2 A;  1M78 A;  3EEK A;  4IXE D;  1RE7 A;  4XT4 A;  1DYI A;  3RG9 A;  1RA8 A;  4PDJ A;  2BL9 A;  4X5J A;  1HFQ A;  4M7V A;  4PTJ A;  1DLS A;  3FY9 X;  3FQZ A;  3SRR X;  1RF7 A;  3IRN A;  4LEK X;  1OHK A;  2DHF A;  1RX5 A;  1RH3 A;  1DRA A;  1DRH A;  1U72 A;  3EX8 A;  4KEB A;  3NZA X;  7DFR A;  4ELH A;  1AI9 A;  4EIZ A;  2P4G A;  3KJR A;  2W3A A;  1J3J A;  1RA2 A;  2D5N A;  4LAE X;  3F0V X;  4ELE A;  1RD7 A;  4XT7 A;  3SH2 A;  2W3V A;  5JG0 X;  1JOL A;  1IA1 A;  4ELG A;  2CIG A;  2XW7 A;  3NXV A;  3F8Y A;  1M79 A;  2W9H A;  5HF0 X;  1SEJ A;  5CCC A;  3F91 A;  3KY8 A;  1DHJ A;  3IRO A;  1JUV A;  1RB3 A;  3UM6 A;  3EEL A;  3F0B X;  3Q1H A;  3JVX A;  4EIL A;  4KFJ A;  4M6L A;  3DAU A;  5EAJ A;  5HF2 X;  4KAK A;  4M6K A;  3NU0 A;  2ZZA A; 
#chains in the Genus database with same CATH topology
 3FYV X;  1JOM A;  3DGA A;  3QFX A;  4XT5 A;  4KLX A;  1DIS A;  3UM5 A;  5HUI A;  2W3B A;  3ZPG A;  3NZD A;  3S7A A;  3DAT A;  1HFR A;  1RX2 A;  3QLX A;  3SQY X;  1RX6 A;  1DR6 A;  3F0X X;  1QZF A;  4KM2 A;  3TD8 A;  4M7U A;  1DR2 A;  1RB2 A;  3E0B A;  1DR3 A;  4QJC A;  4KJK A;  3FL9 A;  3FRE X;  3QLR A;  4HOE A;  1DHF A;  1VJ3 A;  1DLR A;  3SRQ X;  3NRR A;  3F0S X;  5HSR A;  5HVE A;  1RX7 A;  5HT5 A;  3NXY A;  3K74 A;  1HFP A;  3FRD X;  2QK8 A;  3JW5 A;  3JWC A;  3I8A X;  4Q67 A;  3FQO A;  3NXR A;  5HQZ A;  2FZH A;  1RX4 A;  1DR1 A;  1RA1 A;  5HSU A;  1PD8 A;  3VCO A;  3NZB X;  4QHV A;  4XRB A;  3DL6 A;  3NZ6 X;  3QGT A;  3FQV A;  3NZC X;  3KJS A;  3CL9 A;  3K2H A;  4G8Z X;  4QLG A;  1KMS A;  3D80 A;  1S3Y A;  4ELB A;  4QLE A;  1AO8 A;  3QYL A;  1CD2 A;  5U26 A;  3FYW X;  1BOZ A;  2G6V A;  1S3W A;  4ELF A;  4I13 A;  4PTH A;  2W9G A;  4XEC X;  5JA3 A;  1LY4 A;  5E8Q A;  4DDR A;  3SR5 X;  1IA4 A;  3FL8 A;  2LF1 A;  3I3R A;  1PDB A;  2KGK A;  3IX9 A;  3CSE A;  3IRM A;  3FRA X;  8DFR A;  4Q6A A;  4X5G A;  4OSG A;  1RX9 A;  4KM0 A;  1AOE A;  3GHC A;  2AZN A;  3FQF A;  5HI6 A;  1RG7 A;  3NXT A;  5DFR A;  3R33 A;  1KLK A;  3TQB A;  1U70 A;  3RO9 A;  3HBB A;  1DG8 A;  4P68 A;  3EEJ A;  3K47 A;  3FQ0 A;  1D1G A;  1OHJ A;  2W3W A;  3SA2 A;  3JWM A;  1CZ3 A;  3F0Q X;  3JWF A;  3QYO A;  4NX7 A;  4OR7 A;  3TQ8 A;  2HQP A;  2HXV A;  4HOF A;  4X5I A;  3DL5 A;  3QLW A;  1IA3 A;  3QLY A;  2B3Z A;  4H97 A;  1KMV A;  1DYH A;  4LAG X;  4KNE A;  3NTZ A;  2L28 A;  2HM9 A;  1DR4 A;  1RX1 A;  4Q0D A;  1PD9 A;  1ZDR A;  4H98 A;  1DYR A;  3SAI A;  4QJZ D;  3KGY A;  4KJJ A;  3D84 X;  4H95 A;  4RGC A;  2C2T A;  1LY3 A;  3KFY A;  1J3K A;  3DG8 A;  5HVB A;  3GHV A;  5HQY A;  3QLS A;  1RX3 A;  1DRE A;  4XT8 A;  1S3U A;  5DXV A;  1DIU A;  1S3V A;  2O7P A;  4FHB A;  4QI9 A;  4DPD A;  3FS6 A;  1DHI A;  1DRB A;  4CD2 A;  5U27 A;  1MVS A;  2ANO A;  5ECX A;  4P3R A;  1U71 A;  3INV A;  1IA2 A;  2OBC A;  3JSU A;  1RA3 A;  4KD7 A;  3K45 A;  2D0K A;  3M09 A;  1RA9 A;  4XE6 X;  2DRC A;  4P3Q A;  1DYJ A;  3OCH A;  3FRB X;  4I1N A;  3QL3 A;  4XT6 A;  3DFR A;  1LUD A;  3ROA A;  1BZF A;  4KBN A;  3SRW X;  1DG5 A;  3UM8 A;  4KL9 A;  2GD9 A;  3N0H A;  2JYB A;  3LG4 A;  4GH8 A;  3CD2 A;  1DG7 A;  3TQA A;  3FQC A;  3GHW A;  3S3V A;  3JW3 A;  1DF7 A;  4KY8 A;  2ANQ A;  2W3M A;  3FRF X;  4PST A;  5CC9 A;  1RC4 A;  4M6J A;  4P66 A;  4X5H A;  3NXO A;  4KY4 A;  5HT4 A;  4FGH A;  4FGG A;  3NZ9 X;  2BLB A;  4M2X A;  2W9T A;  1VDR A;  4NX6 A;  3SRU X;  3GYF A;  2W9S A;  4LAH X;  4DPH A;  1DR7 A;  3EEM A;  1DR5 A;  1RX8 A;  6DFR A;  3TQ9 A;  3JTW A;  4EJ1 A;  3DRC A;  1E26 A;  3IA4 A;  3GI2 A;  4IXF X;  1DDR A;  4Q0E A;  1M7A A;  3NXX A;  4DP3 A;  3EIG A;  4HA9 A;  3QLZ A;  3QL0 A;  2C2S A;  3FY8 X;  3HJ3 A;  3SRS X;  2H2Q A;  3SA1 A;  4DFR A;  1J3I A;  3OAF A;  1DRF A;  2ITH A;  1DAJ A;  4ECK A;  3F0U X;  1YHO A;  4H96 A;  2BLC A;  1MVT A;  4G3M A;  2INQ A;  4HA7 A;  4HOG A;  4QLF A;  3ZPC A;  2FZJ A;  3SGY A;  3JWK A;  4PSY A;  4KYA A;  3S9U A;  3CLB A;  4IXG X;  3IA5 A;  2OIP A;  4X5F A;  3QG2 A;  4TU5 X;  3F8Z A;  5FDA A;  3M08 A;  4PSS A;  1TDR A;  5ECC A;  5HPB A;  4KJL A;  4G95 A;  2BLA A;  1DDS A;  2FZI A;  4EIG A;  3L3R A;  2CD2 A;  1M78 A;  3EEK A;  4IXE D;  1RE7 A;  4XT4 A;  1DYI A;  3RG9 A;  1RA8 A;  4PDJ A;  2BL9 A;  4X5J A;  1HFQ A;  4M7V A;  4PTJ A;  1DLS A;  3FY9 X;  3FQZ A;  3SRR X;  1RF7 A;  3IRN A;  4LEK X;  1OHK A;  2DHF A;  1RX5 A;  1RH3 A;  1DRA A;  1DRH A;  1U72 A;  3EX8 A;  4KEB A;  3NZA X;  7DFR A;  4ELH A;  1AI9 A;  4EIZ A;  2P4G A;  3KJR A;  2W3A A;  1J3J A;  1RA2 A;  2D5N A;  4LAE X;  3F0V X;  4ELE A;  1RD7 A;  4XT7 A;  3SH2 A;  2W3V A;  5JG0 X;  1JOL A;  1IA1 A;  4ELG A;  2CIG A;  2XW7 A;  3NXV A;  3F8Y A;  1M79 A;  2W9H A;  5HF0 X;  1SEJ A;  5CCC A;  3F91 A;  3KY8 A;  1DHJ A;  3IRO A;  1JUV A;  1RB3 A;  3UM6 A;  3EEL A;  3F0B X;  3Q1H A;  3JVX A;  4EIL A;  4KFJ A;  4M6L A;  3DAU A;  5EAJ A;  5HF2 X;  4KAK A;  4M6K A;  3NU0 A;  2ZZA A; 
#chains in the Genus database with same CATH homology
 3FYV X;  1JOM A;  3DGA A;  3QFX A;  4XT5 A;  4KLX A;  1DIS A;  3UM5 A;  5HUI A;  2W3B A;  3ZPG A;  3NZD A;  3S7A A;  3DAT A;  1HFR A;  1RX2 A;  3QLX A;  3SQY X;  1RX6 A;  1DR6 A;  3F0X X;  1QZF A;  4KM2 A;  3TD8 A;  4M7U A;  1DR2 A;  1RB2 A;  3E0B A;  1DR3 A;  4QJC A;  4KJK A;  3FL9 A;  3FRE X;  3QLR A;  4HOE A;  1DHF A;  1VJ3 A;  1DLR A;  3SRQ X;  3NRR A;  3F0S X;  5HSR A;  5HVE A;  1RX7 A;  5HT5 A;  3NXY A;  3K74 A;  1HFP A;  3FRD X;  2QK8 A;  3JW5 A;  3JWC A;  3I8A X;  4Q67 A;  3FQO A;  3NXR A;  5HQZ A;  2FZH A;  1RX4 A;  1DR1 A;  1RA1 A;  5HSU A;  1PD8 A;  3VCO A;  3NZB X;  4QHV A;  4XRB A;  3DL6 A;  3NZ6 X;  3QGT A;  3FQV A;  3NZC X;  3KJS A;  3CL9 A;  3K2H A;  4G8Z X;  4QLG A;  1KMS A;  3D80 A;  1S3Y A;  4ELB A;  4QLE A;  1AO8 A;  3QYL A;  1CD2 A;  5U26 A;  3FYW X;  1BOZ A;  2G6V A;  1S3W A;  4ELF A;  4I13 A;  4PTH A;  2W9G A;  4XEC X;  5JA3 A;  1LY4 A;  5E8Q A;  4DDR A;  3SR5 X;  1IA4 A;  3FL8 A;  2LF1 A;  3I3R A;  1PDB A;  2KGK A;  3IX9 A;  3CSE A;  3IRM A;  3FRA X;  8DFR A;  4Q6A A;  4X5G A;  4OSG A;  1RX9 A;  4KM0 A;  1AOE A;  3GHC A;  2AZN A;  3FQF A;  5HI6 A;  1RG7 A;  3NXT A;  5DFR A;  3R33 A;  1KLK A;  3TQB A;  1U70 A;  3RO9 A;  3HBB A;  1DG8 A;  4P68 A;  3EEJ A;  3K47 A;  3FQ0 A;  1D1G A;  1OHJ A;  2W3W A;  3SA2 A;  3JWM A;  1CZ3 A;  3F0Q X;  3JWF A;  3QYO A;  4NX7 A;  4OR7 A;  3TQ8 A;  2HQP A;  2HXV A;  4HOF A;  4X5I A;  3DL5 A;  3QLW A;  1IA3 A;  3QLY A;  2B3Z A;  4H97 A;  1KMV A;  1DYH A;  4LAG X;  4KNE A;  3NTZ A;  2L28 A;  2HM9 A;  1DR4 A;  1RX1 A;  4Q0D A;  1PD9 A;  1ZDR A;  4H98 A;  1DYR A;  3SAI A;  4QJZ D;  3KGY A;  4KJJ A;  3D84 X;  4H95 A;  4RGC A;  2C2T A;  1LY3 A;  3KFY A;  1J3K A;  3DG8 A;  5HVB A;  3GHV A;  5HQY A;  3QLS A;  1RX3 A;  1DRE A;  4XT8 A;  1S3U A;  5DXV A;  1DIU A;  1S3V A;  2O7P A;  4FHB A;  4QI9 A;  4DPD A;  3FS6 A;  1DHI A;  1DRB A;  4CD2 A;  5U27 A;  1MVS A;  2ANO A;  5ECX A;  4P3R A;  1U71 A;  3INV A;  1IA2 A;  2OBC A;  3JSU A;  1RA3 A;  4KD7 A;  3K45 A;  2D0K A;  3M09 A;  1RA9 A;  4XE6 X;  2DRC A;  4P3Q A;  1DYJ A;  3OCH A;  3FRB X;  4I1N A;  3QL3 A;  4XT6 A;  3DFR A;  1LUD A;  3ROA A;  1BZF A;  4KBN A;  3SRW X;  1DG5 A;  3UM8 A;  4KL9 A;  2GD9 A;  3N0H A;  2JYB A;  3LG4 A;  4GH8 A;  3CD2 A;  1DG7 A;  3TQA A;  3FQC A;  3GHW A;  3S3V A;  3JW3 A;  1DF7 A;  4KY8 A;  2ANQ A;  2W3M A;  3FRF X;  4PST A;  5CC9 A;  1RC4 A;  4M6J A;  4P66 A;  4X5H A;  3NXO A;  4KY4 A;  5HT4 A;  4FGH A;  4FGG A;  3NZ9 X;  2BLB A;  4M2X A;  2W9T A;  1VDR A;  4NX6 A;  3SRU X;  3GYF A;  2W9S A;  4LAH X;  4DPH A;  1DR7 A;  3EEM A;  1DR5 A;  1RX8 A;  6DFR A;  3TQ9 A;  3JTW A;  4EJ1 A;  3DRC A;  1E26 A;  3IA4 A;  3GI2 A;  4IXF X;  1DDR A;  4Q0E A;  1M7A A;  3NXX A;  4DP3 A;  3EIG A;  4HA9 A;  3QLZ A;  3QL0 A;  2C2S A;  3FY8 X;  3HJ3 A;  3SRS X;  2H2Q A;  3SA1 A;  4DFR A;  1J3I A;  3OAF A;  1DRF A;  2ITH A;  1DAJ A;  4ECK A;  3F0U X;  1YHO A;  4H96 A;  2BLC A;  1MVT A;  4G3M A;  2INQ A;  4HA7 A;  4HOG A;  4QLF A;  3ZPC A;  2FZJ A;  3SGY A;  3JWK A;  4PSY A;  4KYA A;  3S9U A;  3CLB A;  4IXG X;  3IA5 A;  2OIP A;  4X5F A;  3QG2 A;  4TU5 X;  3F8Z A;  5FDA A;  3M08 A;  4PSS A;  1TDR A;  5ECC A;  5HPB A;  4KJL A;  4G95 A;  2BLA A;  1DDS A;  2FZI A;  4EIG A;  3L3R A;  2CD2 A;  1M78 A;  3EEK A;  4IXE D;  1RE7 A;  4XT4 A;  1DYI A;  3RG9 A;  1RA8 A;  4PDJ A;  2BL9 A;  4X5J A;  1HFQ A;  4M7V A;  4PTJ A;  1DLS A;  3FY9 X;  3FQZ A;  3SRR X;  1RF7 A;  3IRN A;  4LEK X;  1OHK A;  2DHF A;  1RX5 A;  1RH3 A;  1DRA A;  1DRH A;  1U72 A;  3EX8 A;  4KEB A;  3NZA X;  7DFR A;  4ELH A;  1AI9 A;  4EIZ A;  2P4G A;  3KJR A;  2W3A A;  1J3J A;  1RA2 A;  2D5N A;  4LAE X;  3F0V X;  4ELE A;  1RD7 A;  4XT7 A;  3SH2 A;  2W3V A;  5JG0 X;  1JOL A;  1IA1 A;  4ELG A;  2CIG A;  2XW7 A;  3NXV A;  3F8Y A;  1M79 A;  2W9H A;  5HF0 X;  1SEJ A;  5CCC A;  3F91 A;  3KY8 A;  1DHJ A;  3IRO A;  1JUV A;  1RB3 A;  3UM6 A;  3EEL A;  3F0B X;  3Q1H A;  3JVX A;  4EIL A;  4KFJ A;  4M6L A;  3DAU A;  5EAJ A;  5HF2 X;  4KAK A;  4M6K A;  3NU0 A;  2ZZA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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