3F0UX

Staphylococcus aureus f98y mutant dihydrofolate reductase complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6-methylpyrimidine
Total Genus 44
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
44
sequence length
157
structure length
157
Chain Sequence
TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLYEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Staphylococcus aureus rf122
molecule keywords Trimethoprim-sensitive dihydrofolate reductase
total genus 44
structure length 157
sequence length 157
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2008-10-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3f0uX00
1M79A 3SA2A 3KJRA 5DXVA 3FYWX 3SRSX 2OBCA 1JOLA 4HOFA 3KGYA 1HFQA 2CIGA 3SGYA 5U27A 3FL9A 1RX1A 4IXGX 1J3KA 4M6JA 5HT4A 1ZDRA 3QLZA 4NX7A 3NXTA 4H97A 1CD2A 5HF2X 1RX7A 1IA1A 1DHJA 2ITHA 1DR4A 3IROA 3QL0A 3IRMA 4QJZD 4KBNA 1RA8A 3DAUA 5HF0X 2W3AA 4PDJA 1DRHA 3QYLA 4QLEA 3JVXA 4KJJA 1RX4A 3KY8A 4ELFA 3F8ZA 2C2SA 5EAJA 5JG0X 4Q0DA 4LAGX 2BLCA 4RGCA 1AO8A 3FL8A 1RX8A 3CL9A 3NU0A 1DR6A 2C2TA 4KM0A 3K74A 1DYIA 3K45A 3NZBX 2FZJA 5HPBA 2QK8A 3FRAX 3EEMA 1M7AA 1RA1A 3RG9A 5U26A 3R33A 1J3JA 5HT5A 1DLRA 5CC9A 1RX6A 3OCHA 1VJ3A 2ANQA 3EEJA 3NXOA 3F0SX 2P4GA 2BLAA 2W9TA 1DG7A 4EIGA 1DR1A 2BLBA 1DDSA 3FQVA 3CSEA 4PSYA 4Q6AA 3IRNA 3SRRX 5HSRA 5HSUA 3FY9X 3JW3A 1DAJA 1MVTA 1DDRA 4KNEA 1DRFA 3DGAA 3TD8A 4X5FA 2W9GA 4Q67A 3GHWA 3JWCA 2XW7A 2HXVA 1RH3A 2W9SA 4KJKA 1RE7A 4I1NA 3SQYX 1DF7A 1BOZA 4XE6X 2H2QA 1TDRA 2ANOA 2W3VA 1RD7A 4X5IA 1S3VA 3FRFX 3CLBA 4M2XA 4FGHA 3EELA 4NX6A 3GI2A 4LAHX 4XRBA 1LY3A 4OSGA 3DRCA 4LAEX 3JWKA 4DFRA 4X5JA 3NZ9X 3NRRA 3F0VX 3EIGA 4CD2A 3JTWA 1DG5A 3NXRA 4ELHA 3CD2A 4M6KA 3IX9A 4XT5A 2CD2A 1DR5A 1M78A 3QLYA 1DHIA 1DYHA 4KEBA 3NZAX 2W3MA 1JUVA 3F0BX 4KM2A 1SEJA 1AI9A 1DRBA 1RB2A 3N0HA 3QLRA 1LUDA 1DISA 3NZDA 5ECXA 3S7AA 2ZZAA 4H96A 4PSSA 6DFRA 4QHVA 4IXED 3F8YA 1S3UA 3QFXA 4KFJA 1RX5A 4XT4A 4KLXA 3FQOA 3QLWA 1CZ3A 4LEKX 3SH2A 3F0QX 4H95A 1DLSA 1AOEA 1IA4A 2W3BA 4Q0EA 1RG7A 4EILA 4GH8A 3Q1HA 1U71A 3D80A 2OIPA 4OR7A 4P66A 3K47A 3M09A 4XECX 2BL9A 1LY4A 2W9HA 3NXXA 3F91A 3NTZA 4IXFX 2LF1A 1IA3A 5ECCA 1RX2A 4PSTA 2B3ZA 1RB3A 4M6LA 1RC4A 3INVA 2FZHA 4KY4A 1DYRA 4EJ1A 3DATA 3QG2A 4FGGA 5HVEA 3QLSA 8DFRA 3K2HA 1RX3A 4ELBA 3HJ3A 5E8QA 3JWMA 4HA9A 3QLXA 3ZPGA 3JWFA 4HOGA 4G95A 1RA2A 1BZFA 5HQYA 3GYFA 1KMSA 2D5NA 3FQ0A 4ELEA 3FQZA 1DG8A 3L3RA 4KY8A 1D1GA 3EX8A 3SR5X 4KAKA 3GHVA 1OHKA 3F0XX 4EIZA 4M7UA 1U72A 3NXYA 4FHBA 3TQAA 3I8AX 3FREX 3ZPCA 4M7VA 3SRQX 1QZFA 3UM8A 1E26A 3DL5A 4X5GA 1HFPA 4QJCA 4DP3A 1DR3A 3VCOA 4XT7A 2HM9A 4ELGA 3SRWX 4KL9A 2JYBA 3SRUX 4HA7A 4DPDA 1S3WA 5DFRA 1YHOA 1DYJA 4QI9A 3FY8X 2DHFA 2AZNA 1DR7A 3NZ6X 3FYVX 4QLFA 3M08A 1IA2A 4KJLA 3QL3A 3DFRA 2FZIA 3TQ9A 1RA3A 1DREA 1RX9A 3HBBA 2DRCA 1MVSA 3JSUA 3ROAA 4P3RA 3DG8A 1HFRA 1PD9A 4I13A 1JOMA 1PD8A 4H98A 1DR2A 1PDBA 3IA5A 4PTHA 3QYOA 1RF7A 2D0KA 5CCCA 2INQA 1U70A 4DDRA 1VDRA 1J3IA 2W3WA 1DIUA 1KMVA 4QLGA 5HI6A 2KGKA 3NZCX 3EEKA 3QGTA 4HOEA 4ECKA 1S3YA 5JA3A 3SAIA 2G6VA 4G3MA 4XT8A 1DRAA 7DFRA 3F0UX 4KD7A 5HVBA 2O7PA 2HQPA 3FS6A 3S9UA 5FDAA 3TQBA 2L28A 3FQCA 1KLKA 3E0BA 3FRDX 3NXVA 3KJSA 4X5HA 4PTJA 1RA9A 3SA1A 4P3QA 1OHJA 3TQ8A 2GD9A 3DL6A 3JW5A 1DHFA 4KYAA 3LG4A 3FQFA 3D84X 3GHCA 5HUIA 3IA4A 4TU5X 4G8ZX 3UM6A 3RO9A 3FRBX 3S3VA 3OAFA 5HQZA 4DPHA 4P68A 3I3RA 4XT6A 3KFYA 3UM5A
chains in the Genus database with same CATH superfamily
1M79A 3SA2A 3KJRA 5DXVA 3FYWX 3SRSX 2OBCA 1JOLA 4HOFA 3KGYA 1HFQA 2CIGA 3SGYA 5U27A 3FL9A 1RX1A 4IXGX 1J3KA 4M6JA 5HT4A 1ZDRA 3QLZA 4NX7A 3NXTA 4H97A 1CD2A 5HF2X 1RX7A 1IA1A 1DHJA 2ITHA 1DR4A 3IROA 3QL0A 3IRMA 4QJZD 4KBNA 1RA8A 3DAUA 5HF0X 2W3AA 4PDJA 1DRHA 3QYLA 4QLEA 3JVXA 4KJJA 1RX4A 3KY8A 4ELFA 3F8ZA 2C2SA 5EAJA 5JG0X 4Q0DA 4LAGX 2BLCA 4RGCA 1AO8A 3FL8A 1RX8A 3CL9A 3NU0A 1DR6A 2C2TA 4KM0A 3K74A 1DYIA 3K45A 3NZBX 2FZJA 5HPBA 2QK8A 3FRAX 3EEMA 1M7AA 1RA1A 3RG9A 5U26A 3R33A 1J3JA 5HT5A 1DLRA 5CC9A 1RX6A 3OCHA 1VJ3A 2ANQA 3EEJA 3NXOA 3F0SX 2P4GA 2BLAA 2W9TA 1DG7A 4EIGA 1DR1A 2BLBA 1DDSA 3FQVA 3CSEA 4PSYA 4Q6AA 3IRNA 3SRRX 5HSRA 5HSUA 3FY9X 3JW3A 1DAJA 1MVTA 1DDRA 4KNEA 1DRFA 3DGAA 3TD8A 4X5FA 2W9GA 4Q67A 3GHWA 3JWCA 2XW7A 2HXVA 1RH3A 2W9SA 4KJKA 1RE7A 4I1NA 3SQYX 1DF7A 1BOZA 4XE6X 2H2QA 1TDRA 2ANOA 2W3VA 1RD7A 4X5IA 1S3VA 3FRFX 3CLBA 4M2XA 4FGHA 3EELA 4NX6A 3GI2A 4LAHX 4XRBA 1LY3A 4OSGA 3DRCA 4LAEX 3JWKA 4DFRA 4X5JA 3NZ9X 3NRRA 3F0VX 3EIGA 4CD2A 3JTWA 1DG5A 3NXRA 4ELHA 3CD2A 4M6KA 3IX9A 4XT5A 2CD2A 1DR5A 1M78A 3QLYA 1DHIA 1DYHA 4KEBA 3NZAX 2W3MA 1JUVA 3F0BX 4KM2A 1SEJA 1AI9A 1DRBA 1RB2A 3N0HA 3QLRA 1LUDA 1DISA 3NZDA 5ECXA 3S7AA 2ZZAA 4H96A 4PSSA 6DFRA 4QHVA 4IXED 3F8YA 1S3UA 3QFXA 4KFJA 1RX5A 4XT4A 4KLXA 3FQOA 3QLWA 1CZ3A 4LEKX 3SH2A 3F0QX 4H95A 1DLSA 1AOEA 1IA4A 2W3BA 4Q0EA 1RG7A 4EILA 4GH8A 3Q1HA 1U71A 3D80A 2OIPA 4OR7A 4P66A 3K47A 3M09A 4XECX 2BL9A 1LY4A 2W9HA 3NXXA 3F91A 3NTZA 4IXFX 2LF1A 1IA3A 5ECCA 1RX2A 4PSTA 2B3ZA 1RB3A 4M6LA 1RC4A 3INVA 2FZHA 4KY4A 1DYRA 4EJ1A 3DATA 3QG2A 4FGGA 5HVEA 3QLSA 8DFRA 3K2HA 1RX3A 4ELBA 3HJ3A 5E8QA 3JWMA 4HA9A 3QLXA 3ZPGA 3JWFA 4HOGA 4G95A 1RA2A 1BZFA 5HQYA 3GYFA 1KMSA 2D5NA 3FQ0A 4ELEA 3FQZA 1DG8A 3L3RA 4KY8A 1D1GA 3EX8A 3SR5X 4KAKA 3GHVA 1OHKA 3F0XX 4EIZA 4M7UA 1U72A 3NXYA 4FHBA 3TQAA 3I8AX 3FREX 3ZPCA 4M7VA 3SRQX 1QZFA 3UM8A 1E26A 3DL5A 4X5GA 1HFPA 4QJCA 4DP3A 1DR3A 3VCOA 4XT7A 2HM9A 4ELGA 3SRWX 4KL9A 2JYBA 3SRUX 4HA7A 4DPDA 1S3WA 5DFRA 1YHOA 1DYJA 4QI9A 3FY8X 2DHFA 2AZNA 1DR7A 3NZ6X 3FYVX 4QLFA 3M08A 1IA2A 4KJLA 3QL3A 3DFRA 2FZIA 3TQ9A 1RA3A 1DREA 1RX9A 3HBBA 2DRCA 1MVSA 3JSUA 3ROAA 4P3RA 3DG8A 1HFRA 1PD9A 4I13A 1JOMA 1PD8A 4H98A 1DR2A 1PDBA 3IA5A 4PTHA 3QYOA 1RF7A 2D0KA 5CCCA 2INQA 1U70A 4DDRA 1VDRA 1J3IA 2W3WA 1DIUA 1KMVA 4QLGA 5HI6A 2KGKA 3NZCX 3EEKA 3QGTA 4HOEA 4ECKA 1S3YA 5JA3A 3SAIA 2G6VA 4G3MA 4XT8A 1DRAA 7DFRA 3F0UX 4KD7A 5HVBA 2O7PA 2HQPA 3FS6A 3S9UA 5FDAA 3TQBA 2L28A 3FQCA 1KLKA 3E0BA 3FRDX 3NXVA 3KJSA 4X5HA 4PTJA 1RA9A 3SA1A 4P3QA 1OHJA 3TQ8A 2GD9A 3DL6A 3JW5A 1DHFA 4KYAA 3LG4A 3FQFA 3D84X 3GHCA 5HUIA 3IA4A 4TU5X 4G8ZX 3UM6A 3RO9A 3FRBX 3S3VA 3OAFA 5HQZA 4DPHA 4P68A 3I3RA 4XT6A 3KFYA 3UM5A
chains in the Genus database with same CATH topology
1M79A 3SA2A 3KJRA 5DXVA 3FYWX 3SRSX 2OBCA 1JOLA 4HOFA 3KGYA 1HFQA 2CIGA 3SGYA 5U27A 3FL9A 1RX1A 4IXGX 1J3KA 4M6JA 5HT4A 1ZDRA 3QLZA 4NX7A 3NXTA 4H97A 1CD2A 5HF2X 1RX7A 1IA1A 1DHJA 2ITHA 1DR4A 3IROA 3QL0A 3IRMA 4QJZD 4KBNA 1RA8A 3DAUA 5HF0X 2W3AA 4PDJA 1DRHA 3QYLA 4QLEA 3JVXA 4KJJA 1RX4A 3KY8A 4ELFA 3F8ZA 2C2SA 5EAJA 5JG0X 4Q0DA 4LAGX 2BLCA 4RGCA 1AO8A 3FL8A 1RX8A 3CL9A 3NU0A 1DR6A 2C2TA 4KM0A 3K74A 1DYIA 3K45A 3NZBX 2FZJA 5HPBA 2QK8A 3FRAX 3EEMA 1M7AA 1RA1A 3RG9A 5U26A 3R33A 1J3JA 5HT5A 1DLRA 5CC9A 1RX6A 3OCHA 1VJ3A 2ANQA 3EEJA 3NXOA 3F0SX 2P4GA 2BLAA 2W9TA 1DG7A 4EIGA 1DR1A 2BLBA 1DDSA 3FQVA 3CSEA 4PSYA 4Q6AA 3IRNA 3SRRX 5HSRA 5HSUA 3FY9X 3JW3A 1DAJA 1MVTA 1DDRA 4KNEA 1DRFA 3DGAA 3TD8A 4X5FA 2W9GA 4Q67A 3GHWA 3JWCA 2XW7A 2HXVA 1RH3A 2W9SA 4KJKA 1RE7A 4I1NA 3SQYX 1DF7A 1BOZA 4XE6X 2H2QA 1TDRA 2ANOA 2W3VA 1RD7A 4X5IA 1S3VA 3FRFX 3CLBA 4M2XA 4FGHA 3EELA 4NX6A 3GI2A 4LAHX 4XRBA 1LY3A 4OSGA 3DRCA 4LAEX 3JWKA 4DFRA 4X5JA 3NZ9X 3NRRA 3F0VX 3EIGA 4CD2A 3JTWA 1DG5A 3NXRA 4ELHA 3CD2A 4M6KA 3IX9A 4XT5A 2CD2A 1DR5A 1M78A 3QLYA 1DHIA 1DYHA 4KEBA 3NZAX 2W3MA 1JUVA 3F0BX 4KM2A 1SEJA 1AI9A 1DRBA 1RB2A 3N0HA 3QLRA 1LUDA 1DISA 3NZDA 5ECXA 3S7AA 2ZZAA 4H96A 4PSSA 6DFRA 4QHVA 4IXED 3F8YA 1S3UA 3QFXA 4KFJA 1RX5A 4XT4A 4KLXA 3FQOA 3QLWA 1CZ3A 4LEKX 3SH2A 3F0QX 4H95A 1DLSA 1AOEA 1IA4A 2W3BA 4Q0EA 1RG7A 4EILA 4GH8A 3Q1HA 1U71A 3D80A 2OIPA 4OR7A 4P66A 3K47A 3M09A 4XECX 2BL9A 1LY4A 2W9HA 3NXXA 3F91A 3NTZA 4IXFX 2LF1A 1IA3A 5ECCA 1RX2A 4PSTA 2B3ZA 1RB3A 4M6LA 1RC4A 3INVA 2FZHA 4KY4A 1DYRA 4EJ1A 3DATA 3QG2A 4FGGA 5HVEA 3QLSA 8DFRA 3K2HA 1RX3A 4ELBA 3HJ3A 5E8QA 3JWMA 4HA9A 3QLXA 3ZPGA 3JWFA 4HOGA 4G95A 1RA2A 1BZFA 5HQYA 3GYFA 1KMSA 2D5NA 3FQ0A 4ELEA 3FQZA 1DG8A 3L3RA 4KY8A 1D1GA 3EX8A 3SR5X 4KAKA 3GHVA 1OHKA 3F0XX 4EIZA 4M7UA 1U72A 3NXYA 4FHBA 3TQAA 3I8AX 3FREX 3ZPCA 4M7VA 3SRQX 1QZFA 3UM8A 1E26A 3DL5A 4X5GA 1HFPA 4QJCA 4DP3A 1DR3A 3VCOA 4XT7A 2HM9A 4ELGA 3SRWX 4KL9A 2JYBA 3SRUX 4HA7A 4DPDA 1S3WA 5DFRA 1YHOA 1DYJA 4QI9A 3FY8X 2DHFA 2AZNA 1DR7A 3NZ6X 3FYVX 4QLFA 3M08A 1IA2A 4KJLA 3QL3A 3DFRA 2FZIA 3TQ9A 1RA3A 1DREA 1RX9A 3HBBA 2DRCA 1MVSA 3JSUA 3ROAA 4P3RA 3DG8A 1HFRA 1PD9A 4I13A 1JOMA 1PD8A 4H98A 1DR2A 1PDBA 3IA5A 4PTHA 3QYOA 1RF7A 2D0KA 5CCCA 2INQA 1U70A 4DDRA 1VDRA 1J3IA 2W3WA 1DIUA 1KMVA 4QLGA 5HI6A 2KGKA 3NZCX 3EEKA 3QGTA 4HOEA 4ECKA 1S3YA 5JA3A 3SAIA 2G6VA 4G3MA 4XT8A 1DRAA 7DFRA 3F0UX 4KD7A 5HVBA 2O7PA 2HQPA 3FS6A 3S9UA 5FDAA 3TQBA 2L28A 3FQCA 1KLKA 3E0BA 3FRDX 3NXVA 3KJSA 4X5HA 4PTJA 1RA9A 3SA1A 4P3QA 1OHJA 3TQ8A 2GD9A 3DL6A 3JW5A 1DHFA 4KYAA 3LG4A 3FQFA 3D84X 3GHCA 5HUIA 3IA4A 4TU5X 4G8ZX 3UM6A 3RO9A 3FRBX 3S3VA 3OAFA 5HQZA 4DPHA 4P68A 3I3RA 4XT6A 3KFYA 3UM5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M79 A;  3SA2 A;  3KJR A;  5DXV A;  3FYW X;  3SRS X;  2OBC A;  1JOL A;  4HOF A;  3KGY A;  1HFQ A;  2CIG A;  3SGY A;  5U27 A;  3FL9 A;  1RX1 A;  4IXG X;  1J3K A;  4M6J A;  5HT4 A;  1ZDR A;  3QLZ A;  4NX7 A;  3NXT A;  4H97 A;  1CD2 A;  5HF2 X;  1RX7 A;  1IA1 A;  1DHJ A;  2ITH A;  1DR4 A;  3IRO A;  3QL0 A;  3IRM A;  4QJZ D;  4KBN A;  1RA8 A;  3DAU A;  5HF0 X;  2W3A A;  4PDJ A;  1DRH A;  3QYL A;  4QLE A;  3JVX A;  4KJJ A;  1RX4 A;  3KY8 A;  4ELF A;  3F8Z A;  2C2S A;  5EAJ A;  5JG0 X;  4Q0D A;  4LAG X;  2BLC A;  4RGC A;  1AO8 A;  3FL8 A;  1RX8 A;  3CL9 A;  3NU0 A;  1DR6 A;  2C2T A;  4KM0 A;  3K74 A;  1DYI A;  3K45 A;  3NZB X;  2FZJ A;  5HPB A;  2QK8 A;  3FRA X;  3EEM A;  1M7A A;  1RA1 A;  3RG9 A;  5U26 A;  3R33 A;  1J3J A;  5HT5 A;  1DLR A;  5CC9 A;  1RX6 A;  3OCH A;  1VJ3 A;  2ANQ A;  3EEJ A;  3NXO A;  3F0S X;  2P4G A;  2BLA A;  2W9T A;  1DG7 A;  4EIG A;  1DR1 A;  2BLB A;  1DDS A;  3FQV A;  3CSE A;  4PSY A;  4Q6A A;  3IRN A;  3SRR X;  5HSR A;  5HSU A;  3FY9 X;  3JW3 A;  1DAJ A;  1MVT A;  1DDR A;  4KNE A;  1DRF A;  3DGA A;  3TD8 A;  4X5F A;  2W9G A;  4Q67 A;  3GHW A;  3JWC A;  2XW7 A;  2HXV A;  1RH3 A;  2W9S A;  4KJK A;  1RE7 A;  4I1N A;  3SQY X;  1DF7 A;  1BOZ A;  4XE6 X;  2H2Q A;  1TDR A;  2ANO A;  2W3V A;  1RD7 A;  4X5I A;  1S3V A;  3FRF X;  3CLB A;  4M2X A;  4FGH A;  3EEL A;  4NX6 A;  3GI2 A;  4LAH X;  4XRB A;  1LY3 A;  4OSG A;  3DRC A;  4LAE X;  3JWK A;  4DFR A;  4X5J A;  3NZ9 X;  3NRR A;  3F0V X;  3EIG A;  4CD2 A;  3JTW A;  1DG5 A;  3NXR A;  4ELH A;  3CD2 A;  4M6K A;  3IX9 A;  4XT5 A;  2CD2 A;  1DR5 A;  1M78 A;  3QLY A;  1DHI A;  1DYH A;  4KEB A;  3NZA X;  2W3M A;  1JUV A;  3F0B X;  4KM2 A;  1SEJ A;  1AI9 A;  1DRB A;  1RB2 A;  3N0H A;  3QLR A;  1LUD A;  1DIS A;  3NZD A;  5ECX A;  3S7A A;  2ZZA A;  4H96 A;  4PSS A;  6DFR A;  4QHV A;  4IXE D;  3F8Y A;  1S3U A;  3QFX A;  4KFJ A;  1RX5 A;  4XT4 A;  4KLX A;  3FQO A;  3QLW A;  1CZ3 A;  4LEK X;  3SH2 A;  3F0Q X;  4H95 A;  1DLS A;  1AOE A;  1IA4 A;  2W3B A;  4Q0E A;  1RG7 A;  4EIL A;  4GH8 A;  3Q1H A;  1U71 A;  3D80 A;  2OIP A;  4OR7 A;  4P66 A;  3K47 A;  3M09 A;  4XEC X;  2BL9 A;  1LY4 A;  2W9H A;  3NXX A;  3F91 A;  3NTZ A;  4IXF X;  2LF1 A;  1IA3 A;  5ECC A;  1RX2 A;  4PST A;  2B3Z A;  1RB3 A;  4M6L A;  1RC4 A;  3INV A;  2FZH A;  4KY4 A;  1DYR A;  4EJ1 A;  3DAT A;  3QG2 A;  4FGG A;  5HVE A;  3QLS A;  8DFR A;  3K2H A;  1RX3 A;  4ELB A;  3HJ3 A;  5E8Q A;  3JWM A;  4HA9 A;  3QLX A;  3ZPG A;  3JWF A;  4HOG A;  4G95 A;  1RA2 A;  1BZF A;  5HQY A;  3GYF A;  1KMS A;  2D5N A;  3FQ0 A;  4ELE A;  3FQZ A;  1DG8 A;  3L3R A;  4KY8 A;  1D1G A;  3EX8 A;  3SR5 X;  4KAK A;  3GHV A;  1OHK A;  3F0X X;  4EIZ A;  4M7U A;  1U72 A;  3NXY A;  4FHB A;  3TQA A;  3I8A X;  3FRE X;  3ZPC A;  4M7V A;  3SRQ X;  1QZF A;  3UM8 A;  1E26 A;  3DL5 A;  4X5G A;  1HFP A;  4QJC A;  4DP3 A;  1DR3 A;  3VCO A;  4XT7 A;  2HM9 A;  4ELG A;  3SRW X;  4KL9 A;  2JYB A;  3SRU X;  4HA7 A;  4DPD A;  1S3W A;  5DFR A;  1YHO A;  1DYJ A;  4QI9 A;  3FY8 X;  2DHF A;  2AZN A;  1DR7 A;  3NZ6 X;  3FYV X;  4QLF A;  3M08 A;  1IA2 A;  4KJL A;  3QL3 A;  3DFR A;  2FZI A;  3TQ9 A;  1RA3 A;  1DRE A;  1RX9 A;  3HBB A;  2DRC A;  1MVS A;  3JSU A;  3ROA A;  4P3R A;  3DG8 A;  1HFR A;  1PD9 A;  4I13 A;  1JOM A;  1PD8 A;  4H98 A;  1DR2 A;  1PDB A;  3IA5 A;  4PTH A;  3QYO A;  1RF7 A;  2D0K A;  5CCC A;  2INQ A;  1U70 A;  4DDR A;  1VDR A;  1J3I A;  2W3W A;  1DIU A;  1KMV A;  4QLG A;  5HI6 A;  2KGK A;  3NZC X;  3EEK A;  3QGT A;  4HOE A;  4ECK A;  1S3Y A;  5JA3 A;  3SAI A;  2G6V A;  4G3M A;  4XT8 A;  1DRA A;  7DFR A;  3F0U X;  4KD7 A;  5HVB A;  2O7P A;  2HQP A;  3FS6 A;  3S9U A;  5FDA A;  3TQB A;  2L28 A;  3FQC A;  1KLK A;  3E0B A;  3FRD X;  3NXV A;  3KJS A;  4X5H A;  4PTJ A;  1RA9 A;  3SA1 A;  4P3Q A;  1OHJ A;  3TQ8 A;  2GD9 A;  3DL6 A;  3JW5 A;  1DHF A;  4KYA A;  3LG4 A;  3FQF A;  3D84 X;  3GHC A;  5HUI A;  3IA4 A;  4TU5 X;  4G8Z X;  3UM6 A;  3RO9 A;  3FRB X;  3S3V A;  3OAF A;  5HQZ A;  4DPH A;  4P68 A;  3I3R A;  4XT6 A;  3KFY A;  3UM5 A; 
#chains in the Genus database with same CATH topology
 1M79 A;  3SA2 A;  3KJR A;  5DXV A;  3FYW X;  3SRS X;  2OBC A;  1JOL A;  4HOF A;  3KGY A;  1HFQ A;  2CIG A;  3SGY A;  5U27 A;  3FL9 A;  1RX1 A;  4IXG X;  1J3K A;  4M6J A;  5HT4 A;  1ZDR A;  3QLZ A;  4NX7 A;  3NXT A;  4H97 A;  1CD2 A;  5HF2 X;  1RX7 A;  1IA1 A;  1DHJ A;  2ITH A;  1DR4 A;  3IRO A;  3QL0 A;  3IRM A;  4QJZ D;  4KBN A;  1RA8 A;  3DAU A;  5HF0 X;  2W3A A;  4PDJ A;  1DRH A;  3QYL A;  4QLE A;  3JVX A;  4KJJ A;  1RX4 A;  3KY8 A;  4ELF A;  3F8Z A;  2C2S A;  5EAJ A;  5JG0 X;  4Q0D A;  4LAG X;  2BLC A;  4RGC A;  1AO8 A;  3FL8 A;  1RX8 A;  3CL9 A;  3NU0 A;  1DR6 A;  2C2T A;  4KM0 A;  3K74 A;  1DYI A;  3K45 A;  3NZB X;  2FZJ A;  5HPB A;  2QK8 A;  3FRA X;  3EEM A;  1M7A A;  1RA1 A;  3RG9 A;  5U26 A;  3R33 A;  1J3J A;  5HT5 A;  1DLR A;  5CC9 A;  1RX6 A;  3OCH A;  1VJ3 A;  2ANQ A;  3EEJ A;  3NXO A;  3F0S X;  2P4G A;  2BLA A;  2W9T A;  1DG7 A;  4EIG A;  1DR1 A;  2BLB A;  1DDS A;  3FQV A;  3CSE A;  4PSY A;  4Q6A A;  3IRN A;  3SRR X;  5HSR A;  5HSU A;  3FY9 X;  3JW3 A;  1DAJ A;  1MVT A;  1DDR A;  4KNE A;  1DRF A;  3DGA A;  3TD8 A;  4X5F A;  2W9G A;  4Q67 A;  3GHW A;  3JWC A;  2XW7 A;  2HXV A;  1RH3 A;  2W9S A;  4KJK A;  1RE7 A;  4I1N A;  3SQY X;  1DF7 A;  1BOZ A;  4XE6 X;  2H2Q A;  1TDR A;  2ANO A;  2W3V A;  1RD7 A;  4X5I A;  1S3V A;  3FRF X;  3CLB A;  4M2X A;  4FGH A;  3EEL A;  4NX6 A;  3GI2 A;  4LAH X;  4XRB A;  1LY3 A;  4OSG A;  3DRC A;  4LAE X;  3JWK A;  4DFR A;  4X5J A;  3NZ9 X;  3NRR A;  3F0V X;  3EIG A;  4CD2 A;  3JTW A;  1DG5 A;  3NXR A;  4ELH A;  3CD2 A;  4M6K A;  3IX9 A;  4XT5 A;  2CD2 A;  1DR5 A;  1M78 A;  3QLY A;  1DHI A;  1DYH A;  4KEB A;  3NZA X;  2W3M A;  1JUV A;  3F0B X;  4KM2 A;  1SEJ A;  1AI9 A;  1DRB A;  1RB2 A;  3N0H A;  3QLR A;  1LUD A;  1DIS A;  3NZD A;  5ECX A;  3S7A A;  2ZZA A;  4H96 A;  4PSS A;  6DFR A;  4QHV A;  4IXE D;  3F8Y A;  1S3U A;  3QFX A;  4KFJ A;  1RX5 A;  4XT4 A;  4KLX A;  3FQO A;  3QLW A;  1CZ3 A;  4LEK X;  3SH2 A;  3F0Q X;  4H95 A;  1DLS A;  1AOE A;  1IA4 A;  2W3B A;  4Q0E A;  1RG7 A;  4EIL A;  4GH8 A;  3Q1H A;  1U71 A;  3D80 A;  2OIP A;  4OR7 A;  4P66 A;  3K47 A;  3M09 A;  4XEC X;  2BL9 A;  1LY4 A;  2W9H A;  3NXX A;  3F91 A;  3NTZ A;  4IXF X;  2LF1 A;  1IA3 A;  5ECC A;  1RX2 A;  4PST A;  2B3Z A;  1RB3 A;  4M6L A;  1RC4 A;  3INV A;  2FZH A;  4KY4 A;  1DYR A;  4EJ1 A;  3DAT A;  3QG2 A;  4FGG A;  5HVE A;  3QLS A;  8DFR A;  3K2H A;  1RX3 A;  4ELB A;  3HJ3 A;  5E8Q A;  3JWM A;  4HA9 A;  3QLX A;  3ZPG A;  3JWF A;  4HOG A;  4G95 A;  1RA2 A;  1BZF A;  5HQY A;  3GYF A;  1KMS A;  2D5N A;  3FQ0 A;  4ELE A;  3FQZ A;  1DG8 A;  3L3R A;  4KY8 A;  1D1G A;  3EX8 A;  3SR5 X;  4KAK A;  3GHV A;  1OHK A;  3F0X X;  4EIZ A;  4M7U A;  1U72 A;  3NXY A;  4FHB A;  3TQA A;  3I8A X;  3FRE X;  3ZPC A;  4M7V A;  3SRQ X;  1QZF A;  3UM8 A;  1E26 A;  3DL5 A;  4X5G A;  1HFP A;  4QJC A;  4DP3 A;  1DR3 A;  3VCO A;  4XT7 A;  2HM9 A;  4ELG A;  3SRW X;  4KL9 A;  2JYB A;  3SRU X;  4HA7 A;  4DPD A;  1S3W A;  5DFR A;  1YHO A;  1DYJ A;  4QI9 A;  3FY8 X;  2DHF A;  2AZN A;  1DR7 A;  3NZ6 X;  3FYV X;  4QLF A;  3M08 A;  1IA2 A;  4KJL A;  3QL3 A;  3DFR A;  2FZI A;  3TQ9 A;  1RA3 A;  1DRE A;  1RX9 A;  3HBB A;  2DRC A;  1MVS A;  3JSU A;  3ROA A;  4P3R A;  3DG8 A;  1HFR A;  1PD9 A;  4I13 A;  1JOM A;  1PD8 A;  4H98 A;  1DR2 A;  1PDB A;  3IA5 A;  4PTH A;  3QYO A;  1RF7 A;  2D0K A;  5CCC A;  2INQ A;  1U70 A;  4DDR A;  1VDR A;  1J3I A;  2W3W A;  1DIU A;  1KMV A;  4QLG A;  5HI6 A;  2KGK A;  3NZC X;  3EEK A;  3QGT A;  4HOE A;  4ECK A;  1S3Y A;  5JA3 A;  3SAI A;  2G6V A;  4G3M A;  4XT8 A;  1DRA A;  7DFR A;  3F0U X;  4KD7 A;  5HVB A;  2O7P A;  2HQP A;  3FS6 A;  3S9U A;  5FDA A;  3TQB A;  2L28 A;  3FQC A;  1KLK A;  3E0B A;  3FRD X;  3NXV A;  3KJS A;  4X5H A;  4PTJ A;  1RA9 A;  3SA1 A;  4P3Q A;  1OHJ A;  3TQ8 A;  2GD9 A;  3DL6 A;  3JW5 A;  1DHF A;  4KYA A;  3LG4 A;  3FQF A;  3D84 X;  3GHC A;  5HUI A;  3IA4 A;  4TU5 X;  4G8Z X;  3UM6 A;  3RO9 A;  3FRB X;  3S3V A;  3OAF A;  5HQZ A;  4DPH A;  4P68 A;  3I3R A;  4XT6 A;  3KFY A;  3UM5 A; 
#chains in the Genus database with same CATH homology
 1M79 A;  3SA2 A;  3KJR A;  5DXV A;  3FYW X;  3SRS X;  2OBC A;  1JOL A;  4HOF A;  3KGY A;  1HFQ A;  2CIG A;  3SGY A;  5U27 A;  3FL9 A;  1RX1 A;  4IXG X;  1J3K A;  4M6J A;  5HT4 A;  1ZDR A;  3QLZ A;  4NX7 A;  3NXT A;  4H97 A;  1CD2 A;  5HF2 X;  1RX7 A;  1IA1 A;  1DHJ A;  2ITH A;  1DR4 A;  3IRO A;  3QL0 A;  3IRM A;  4QJZ D;  4KBN A;  1RA8 A;  3DAU A;  5HF0 X;  2W3A A;  4PDJ A;  1DRH A;  3QYL A;  4QLE A;  3JVX A;  4KJJ A;  1RX4 A;  3KY8 A;  4ELF A;  3F8Z A;  2C2S A;  5EAJ A;  5JG0 X;  4Q0D A;  4LAG X;  2BLC A;  4RGC A;  1AO8 A;  3FL8 A;  1RX8 A;  3CL9 A;  3NU0 A;  1DR6 A;  2C2T A;  4KM0 A;  3K74 A;  1DYI A;  3K45 A;  3NZB X;  2FZJ A;  5HPB A;  2QK8 A;  3FRA X;  3EEM A;  1M7A A;  1RA1 A;  3RG9 A;  5U26 A;  3R33 A;  1J3J A;  5HT5 A;  1DLR A;  5CC9 A;  1RX6 A;  3OCH A;  1VJ3 A;  2ANQ A;  3EEJ A;  3NXO A;  3F0S X;  2P4G A;  2BLA A;  2W9T A;  1DG7 A;  4EIG A;  1DR1 A;  2BLB A;  1DDS A;  3FQV A;  3CSE A;  4PSY A;  4Q6A A;  3IRN A;  3SRR X;  5HSR A;  5HSU A;  3FY9 X;  3JW3 A;  1DAJ A;  1MVT A;  1DDR A;  4KNE A;  1DRF A;  3DGA A;  3TD8 A;  4X5F A;  2W9G A;  4Q67 A;  3GHW A;  3JWC A;  2XW7 A;  2HXV A;  1RH3 A;  2W9S A;  4KJK A;  1RE7 A;  4I1N A;  3SQY X;  1DF7 A;  1BOZ A;  4XE6 X;  2H2Q A;  1TDR A;  2ANO A;  2W3V A;  1RD7 A;  4X5I A;  1S3V A;  3FRF X;  3CLB A;  4M2X A;  4FGH A;  3EEL A;  4NX6 A;  3GI2 A;  4LAH X;  4XRB A;  1LY3 A;  4OSG A;  3DRC A;  4LAE X;  3JWK A;  4DFR A;  4X5J A;  3NZ9 X;  3NRR A;  3F0V X;  3EIG A;  4CD2 A;  3JTW A;  1DG5 A;  3NXR A;  4ELH A;  3CD2 A;  4M6K A;  3IX9 A;  4XT5 A;  2CD2 A;  1DR5 A;  1M78 A;  3QLY A;  1DHI A;  1DYH A;  4KEB A;  3NZA X;  2W3M A;  1JUV A;  3F0B X;  4KM2 A;  1SEJ A;  1AI9 A;  1DRB A;  1RB2 A;  3N0H A;  3QLR A;  1LUD A;  1DIS A;  3NZD A;  5ECX A;  3S7A A;  2ZZA A;  4H96 A;  4PSS A;  6DFR A;  4QHV A;  4IXE D;  3F8Y A;  1S3U A;  3QFX A;  4KFJ A;  1RX5 A;  4XT4 A;  4KLX A;  3FQO A;  3QLW A;  1CZ3 A;  4LEK X;  3SH2 A;  3F0Q X;  4H95 A;  1DLS A;  1AOE A;  1IA4 A;  2W3B A;  4Q0E A;  1RG7 A;  4EIL A;  4GH8 A;  3Q1H A;  1U71 A;  3D80 A;  2OIP A;  4OR7 A;  4P66 A;  3K47 A;  3M09 A;  4XEC X;  2BL9 A;  1LY4 A;  2W9H A;  3NXX A;  3F91 A;  3NTZ A;  4IXF X;  2LF1 A;  1IA3 A;  5ECC A;  1RX2 A;  4PST A;  2B3Z A;  1RB3 A;  4M6L A;  1RC4 A;  3INV A;  2FZH A;  4KY4 A;  1DYR A;  4EJ1 A;  3DAT A;  3QG2 A;  4FGG A;  5HVE A;  3QLS A;  8DFR A;  3K2H A;  1RX3 A;  4ELB A;  3HJ3 A;  5E8Q A;  3JWM A;  4HA9 A;  3QLX A;  3ZPG A;  3JWF A;  4HOG A;  4G95 A;  1RA2 A;  1BZF A;  5HQY A;  3GYF A;  1KMS A;  2D5N A;  3FQ0 A;  4ELE A;  3FQZ A;  1DG8 A;  3L3R A;  4KY8 A;  1D1G A;  3EX8 A;  3SR5 X;  4KAK A;  3GHV A;  1OHK A;  3F0X X;  4EIZ A;  4M7U A;  1U72 A;  3NXY A;  4FHB A;  3TQA A;  3I8A X;  3FRE X;  3ZPC A;  4M7V A;  3SRQ X;  1QZF A;  3UM8 A;  1E26 A;  3DL5 A;  4X5G A;  1HFP A;  4QJC A;  4DP3 A;  1DR3 A;  3VCO A;  4XT7 A;  2HM9 A;  4ELG A;  3SRW X;  4KL9 A;  2JYB A;  3SRU X;  4HA7 A;  4DPD A;  1S3W A;  5DFR A;  1YHO A;  1DYJ A;  4QI9 A;  3FY8 X;  2DHF A;  2AZN A;  1DR7 A;  3NZ6 X;  3FYV X;  4QLF A;  3M08 A;  1IA2 A;  4KJL A;  3QL3 A;  3DFR A;  2FZI A;  3TQ9 A;  1RA3 A;  1DRE A;  1RX9 A;  3HBB A;  2DRC A;  1MVS A;  3JSU A;  3ROA A;  4P3R A;  3DG8 A;  1HFR A;  1PD9 A;  4I13 A;  1JOM A;  1PD8 A;  4H98 A;  1DR2 A;  1PDB A;  3IA5 A;  4PTH A;  3QYO A;  1RF7 A;  2D0K A;  5CCC A;  2INQ A;  1U70 A;  4DDR A;  1VDR A;  1J3I A;  2W3W A;  1DIU A;  1KMV A;  4QLG A;  5HI6 A;  2KGK A;  3NZC X;  3EEK A;  3QGT A;  4HOE A;  4ECK A;  1S3Y A;  5JA3 A;  3SAI A;  2G6V A;  4G3M A;  4XT8 A;  1DRA A;  7DFR A;  3F0U X;  4KD7 A;  5HVB A;  2O7P A;  2HQP A;  3FS6 A;  3S9U A;  5FDA A;  3TQB A;  2L28 A;  3FQC A;  1KLK A;  3E0B A;  3FRD X;  3NXV A;  3KJS A;  4X5H A;  4PTJ A;  1RA9 A;  3SA1 A;  4P3Q A;  1OHJ A;  3TQ8 A;  2GD9 A;  3DL6 A;  3JW5 A;  1DHF A;  4KYA A;  3LG4 A;  3FQF A;  3D84 X;  3GHC A;  5HUI A;  3IA4 A;  4TU5 X;  4G8Z X;  3UM6 A;  3RO9 A;  3FRB X;  3S3V A;  3OAF A;  5HQZ A;  4DPH A;  4P68 A;  3I3R A;  4XT6 A;  3KFY A;  3UM5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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