3FRDX

S. aureus dhfr complexed with nadph and folate
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
157
structure length
157
Chain Sequence
TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Staphylococcus aureus
molecule keywords Dihydrofolate reductase
total genus 40
structure length 157
sequence length 157
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3frdX00
3F0VX 3JWFA 2B3ZA 5HVBA 1KLKA 3DL5A 4KY8A 4EJ1A 1RB2A 5HT4A 4CD2A 3FQVA 3HJ3A 3SAIA 3NXTA 4KLXA 2OBCA 3I3RA 4KJLA 4KFJA 4M2XA 3RG9A 4I13A 3VCOA 1RX8A 2QK8A 1U70A 3QL3A 1DISA 4XRBA 4G3MA 3K2HA 3NZCX 1RX7A 3F91A 4IXGX 3F0BX 3EX8A 4X5HA 3JWCA 4PDJA 1DF7A 3DFRA 2W9TA 1RX1A 4G95A 1DYJA 4XT6A 4ELHA 1RD7A 1DHFA 4QHVA 1M78A 3JW5A 1LY3A 1MVSA 3KJSA 3K74A 3CSEA 1DDSA 2P4GA 3F0UX 2W3VA 3EEJA 4DDRA 3SR5X 3QYLA 3GHCA 5CCCA 4RGCA 4XT8A 4ECKA 1S3VA 3D84X 4LAGX 3Q1HA 3S3VA 4XT7A 1JOLA 2BL9A 3FYWX 3TQ9A 3SRRX 3QYOA 3ROAA 1DR3A 5HQYA 1JOMA 2W3WA 2W3MA 1M79A 2ZZAA 4LAHX 4Q67A 1OHKA 1KMSA 3NZAX 1E26A 4KBNA 4OR7A 3SRUX 3DG8A 3NZ6X 3F8YA 4KD7A 2INQA 3INVA 3KY8A 1RX4A 1QZFA 2L28A 2DRCA 3FL8A 2FZHA 3TQ8A 1YHOA 4X5IA 5HQZA 7DFRA 1DR7A 3KFYA 1DRBA 4ELFA 2ITHA 1RA1A 1KMVA 1M7AA 3E0BA 3SH2A 4KJJA 4H97A 4EIGA 2CIGA 3JSUA 4IXED 1RG7A 2KGKA 1DYIA 1CZ3A 2GD9A 3ZPGA 2HQPA 5HPBA 4DFRA 4KM0A 1DDRA 1DAJA 4TU5X 1AOEA 4P3RA 1AO8A 3NXYA 4HOGA 5HI6A 4ELGA 2JYBA 3FS6A 1PD9A 2W3AA 3SRWX 2D0KA 3IROA 4M6KA 5U26A 5JG0X 4ELBA 1D1GA 4PTJA 3FRDX 4HOEA 3UM5A 5E8QA 3CLBA 4M7UA 2FZJA 1J3JA 5HSRA 3NRRA 4M7VA 3K47A 1DIUA 1DG8A 4M6LA 1RX3A 3NZ9X 5ECXA 4ELEA 5HF0X 4I1NA 1IA1A 3DAUA 1PDBA 3SGYA 3F0QX 4PSSA 1DHIA 4EILA 3QLYA 3NXRA 8DFRA 3IA4A 3FRAX 2AZNA 4PSYA 3QG2A 3R33A 3M09A 4KM2A 3TQAA 3KJRA 4KL9A 3S9UA 2BLCA 4KAKA 1DLSA 3FRBX 3SA2A 3N0HA 2ANOA 3NU0A 4QLEA 1CD2A 5DFRA 3JVXA 1DRHA 1OHJA 4X5FA 1HFRA 2C2TA 4KEBA 3QLWA 2XW7A 1IA2A 3IRNA 4NX7A 3ZPCA 4XT4A 5DXVA 5EAJA 4NX6A 4IXFX 2C2SA 3JWMA 1DG5A 4KNEA 1AI9A 2FZIA 4P3QA 3GI2A 2CD2A 2HM9A 6DFRA 2DHFA 3UM8A 3SA1A 3NXOA 1RB3A 4HOFA 3SQYX 3TD8A 2BLBA 2W9HA 1LUDA 3NTZA 1DREA 1S3UA 3RO9A 1LY4A 1RA2A 3FY9X 1RX5A 3EEMA 1DHJA 3JTWA 3HBBA 1IA4A 4KY4A 4M6JA 5HF2X 4P68A 1DRAA 3SRSX 2ANQA 3NZDA 3F8ZA 3FQCA 1DLRA 4KYAA 3FY8X 3F0SX 1TDRA 4X5JA 4FHBA 2H2QA 3I8AX 3FRFX 4FGHA 5FDAA 3FQOA 4LEKX 1DR4A 5HSUA 3SRQX 2O7PA 3JWKA 3QGTA 3OAFA 4FGGA 5JA3A 1RX6A 4P66A 1RA3A 1J3KA 2G6VA 1VJ3A 3LG4A 3JW3A 5U27A 5ECCA 5HT5A 4LAEX 3IX9A 4EIZA 1DYRA 1RX9A 4XT5A 1RA8A 4QLGA 3UM6A 3FL9A 3EIGA 1DG7A 3DATA 3TQBA 4HA7A 4QI9A 3CD2A 3FREX 3D80A 5HVEA 4OSGA 3K45A 4XECX 3GYFA 1U71A 3FQ0A 3QL0A 4QLFA 4DP3A 3M08A 3DL6A 3CL9A 4XE6X 1RF7A 1SEJA 3KGYA 1MVTA 1PD8A 1BOZA 1DR1A 1RX2A 2OIPA 4H96A 1JUVA 2HXVA 3DRCA 3GHVA 3OCHA 4Q0DA 4GH8A 3DGAA 3IRMA 1S3WA 3QLXA 1VDRA 1DYHA 1ZDRA 1DR6A 4DPHA 3NXVA 1HFQA 4Q0EA 3QLSA 2W9SA 2LF1A 1DRFA 1DR5A 1IA3A 3S7AA 4H98A 1DR2A 4DPDA 4G8ZX 3NXXA 2W3BA 3NZBX 4QJZD 4H95A 3EEKA 4PSTA 4QJCA 3L3RA 1RE7A 1U72A 3EELA 3QLRA 3F0XX 1HFPA 1RA9A 3FYVX 3FQFA 4KJKA 5CC9A 3GHWA 1S3YA 2BLAA 1RH3A 4HA9A 4Q6AA 3QFXA 2D5NA 3QLZA 1J3IA 4X5GA 5HUIA 2W9GA 3FQZA 1BZFA 4PTHA 3IA5A 1RC4A
chains in the Genus database with same CATH superfamily
3F0VX 3JWFA 2B3ZA 5HVBA 1KLKA 3DL5A 4KY8A 4EJ1A 1RB2A 5HT4A 4CD2A 3FQVA 3HJ3A 3SAIA 3NXTA 4KLXA 2OBCA 3I3RA 4KJLA 4KFJA 4M2XA 3RG9A 4I13A 3VCOA 1RX8A 2QK8A 1U70A 3QL3A 1DISA 4XRBA 4G3MA 3K2HA 3NZCX 1RX7A 3F91A 4IXGX 3F0BX 3EX8A 4X5HA 3JWCA 4PDJA 1DF7A 3DFRA 2W9TA 1RX1A 4G95A 1DYJA 4XT6A 4ELHA 1RD7A 1DHFA 4QHVA 1M78A 3JW5A 1LY3A 1MVSA 3KJSA 3K74A 3CSEA 1DDSA 2P4GA 3F0UX 2W3VA 3EEJA 4DDRA 3SR5X 3QYLA 3GHCA 5CCCA 4RGCA 4XT8A 4ECKA 1S3VA 3D84X 4LAGX 3Q1HA 3S3VA 4XT7A 1JOLA 2BL9A 3FYWX 3TQ9A 3SRRX 3QYOA 3ROAA 1DR3A 5HQYA 1JOMA 2W3WA 2W3MA 1M79A 2ZZAA 4LAHX 4Q67A 1OHKA 1KMSA 3NZAX 1E26A 4KBNA 4OR7A 3SRUX 3DG8A 3NZ6X 3F8YA 4KD7A 2INQA 3INVA 3KY8A 1RX4A 1QZFA 2L28A 2DRCA 3FL8A 2FZHA 3TQ8A 1YHOA 4X5IA 5HQZA 7DFRA 1DR7A 3KFYA 1DRBA 4ELFA 2ITHA 1RA1A 1KMVA 1M7AA 3E0BA 3SH2A 4KJJA 4H97A 4EIGA 2CIGA 3JSUA 4IXED 1RG7A 2KGKA 1DYIA 1CZ3A 2GD9A 3ZPGA 2HQPA 5HPBA 4DFRA 4KM0A 1DDRA 1DAJA 4TU5X 1AOEA 4P3RA 1AO8A 3NXYA 4HOGA 5HI6A 4ELGA 2JYBA 3FS6A 1PD9A 2W3AA 3SRWX 2D0KA 3IROA 4M6KA 5U26A 5JG0X 4ELBA 1D1GA 4PTJA 3FRDX 4HOEA 3UM5A 5E8QA 3CLBA 4M7UA 2FZJA 1J3JA 5HSRA 3NRRA 4M7VA 3K47A 1DIUA 1DG8A 4M6LA 1RX3A 3NZ9X 5ECXA 4ELEA 5HF0X 4I1NA 1IA1A 3DAUA 1PDBA 3SGYA 3F0QX 4PSSA 1DHIA 4EILA 3QLYA 3NXRA 8DFRA 3IA4A 3FRAX 2AZNA 4PSYA 3QG2A 3R33A 3M09A 4KM2A 3TQAA 3KJRA 4KL9A 3S9UA 2BLCA 4KAKA 1DLSA 3FRBX 3SA2A 3N0HA 2ANOA 3NU0A 4QLEA 1CD2A 5DFRA 3JVXA 1DRHA 1OHJA 4X5FA 1HFRA 2C2TA 4KEBA 3QLWA 2XW7A 1IA2A 3IRNA 4NX7A 3ZPCA 4XT4A 5DXVA 5EAJA 4NX6A 4IXFX 2C2SA 3JWMA 1DG5A 4KNEA 1AI9A 2FZIA 4P3QA 3GI2A 2CD2A 2HM9A 6DFRA 2DHFA 3UM8A 3SA1A 3NXOA 1RB3A 4HOFA 3SQYX 3TD8A 2BLBA 2W9HA 1LUDA 3NTZA 1DREA 1S3UA 3RO9A 1LY4A 1RA2A 3FY9X 1RX5A 3EEMA 1DHJA 3JTWA 3HBBA 1IA4A 4KY4A 4M6JA 5HF2X 4P68A 1DRAA 3SRSX 2ANQA 3NZDA 3F8ZA 3FQCA 1DLRA 4KYAA 3FY8X 3F0SX 1TDRA 4X5JA 4FHBA 2H2QA 3I8AX 3FRFX 4FGHA 5FDAA 3FQOA 4LEKX 1DR4A 5HSUA 3SRQX 2O7PA 3JWKA 3QGTA 3OAFA 4FGGA 5JA3A 1RX6A 4P66A 1RA3A 1J3KA 2G6VA 1VJ3A 3LG4A 3JW3A 5U27A 5ECCA 5HT5A 4LAEX 3IX9A 4EIZA 1DYRA 1RX9A 4XT5A 1RA8A 4QLGA 3UM6A 3FL9A 3EIGA 1DG7A 3DATA 3TQBA 4HA7A 4QI9A 3CD2A 3FREX 3D80A 5HVEA 4OSGA 3K45A 4XECX 3GYFA 1U71A 3FQ0A 3QL0A 4QLFA 4DP3A 3M08A 3DL6A 3CL9A 4XE6X 1RF7A 1SEJA 3KGYA 1MVTA 1PD8A 1BOZA 1DR1A 1RX2A 2OIPA 4H96A 1JUVA 2HXVA 3DRCA 3GHVA 3OCHA 4Q0DA 4GH8A 3DGAA 3IRMA 1S3WA 3QLXA 1VDRA 1DYHA 1ZDRA 1DR6A 4DPHA 3NXVA 1HFQA 4Q0EA 3QLSA 2W9SA 2LF1A 1DRFA 1DR5A 1IA3A 3S7AA 4H98A 1DR2A 4DPDA 4G8ZX 3NXXA 2W3BA 3NZBX 4QJZD 4H95A 3EEKA 4PSTA 4QJCA 3L3RA 1RE7A 1U72A 3EELA 3QLRA 3F0XX 1HFPA 1RA9A 3FYVX 3FQFA 4KJKA 5CC9A 3GHWA 1S3YA 2BLAA 1RH3A 4HA9A 4Q6AA 3QFXA 2D5NA 3QLZA 1J3IA 4X5GA 5HUIA 2W9GA 3FQZA 1BZFA 4PTHA 3IA5A 1RC4A
chains in the Genus database with same CATH topology
3F0VX 3JWFA 2B3ZA 5HVBA 1KLKA 3DL5A 4KY8A 4EJ1A 1RB2A 5HT4A 4CD2A 3FQVA 3HJ3A 3SAIA 3NXTA 4KLXA 2OBCA 3I3RA 4KJLA 4KFJA 4M2XA 3RG9A 4I13A 3VCOA 1RX8A 2QK8A 1U70A 3QL3A 1DISA 4XRBA 4G3MA 3K2HA 3NZCX 1RX7A 3F91A 4IXGX 3F0BX 3EX8A 4X5HA 3JWCA 4PDJA 1DF7A 3DFRA 2W9TA 1RX1A 4G95A 1DYJA 4XT6A 4ELHA 1RD7A 1DHFA 4QHVA 1M78A 3JW5A 1LY3A 1MVSA 3KJSA 3K74A 3CSEA 1DDSA 2P4GA 3F0UX 2W3VA 3EEJA 4DDRA 3SR5X 3QYLA 3GHCA 5CCCA 4RGCA 4XT8A 4ECKA 1S3VA 3D84X 4LAGX 3Q1HA 3S3VA 4XT7A 1JOLA 2BL9A 3FYWX 3TQ9A 3SRRX 3QYOA 3ROAA 1DR3A 5HQYA 1JOMA 2W3WA 2W3MA 1M79A 2ZZAA 4LAHX 4Q67A 1OHKA 1KMSA 3NZAX 1E26A 4KBNA 4OR7A 3SRUX 3DG8A 3NZ6X 3F8YA 4KD7A 2INQA 3INVA 3KY8A 1RX4A 1QZFA 2L28A 2DRCA 3FL8A 2FZHA 3TQ8A 1YHOA 4X5IA 5HQZA 7DFRA 1DR7A 3KFYA 1DRBA 4ELFA 2ITHA 1RA1A 1KMVA 1M7AA 3E0BA 3SH2A 4KJJA 4H97A 4EIGA 2CIGA 3JSUA 4IXED 1RG7A 2KGKA 1DYIA 1CZ3A 2GD9A 3ZPGA 2HQPA 5HPBA 4DFRA 4KM0A 1DDRA 1DAJA 4TU5X 1AOEA 4P3RA 1AO8A 3NXYA 4HOGA 5HI6A 4ELGA 2JYBA 3FS6A 1PD9A 2W3AA 3SRWX 2D0KA 3IROA 4M6KA 5U26A 5JG0X 4ELBA 1D1GA 4PTJA 3FRDX 4HOEA 3UM5A 5E8QA 3CLBA 4M7UA 2FZJA 1J3JA 5HSRA 3NRRA 4M7VA 3K47A 1DIUA 1DG8A 4M6LA 1RX3A 3NZ9X 5ECXA 4ELEA 5HF0X 4I1NA 1IA1A 3DAUA 1PDBA 3SGYA 3F0QX 4PSSA 1DHIA 4EILA 3QLYA 3NXRA 8DFRA 3IA4A 3FRAX 2AZNA 4PSYA 3QG2A 3R33A 3M09A 4KM2A 3TQAA 3KJRA 4KL9A 3S9UA 2BLCA 4KAKA 1DLSA 3FRBX 3SA2A 3N0HA 2ANOA 3NU0A 4QLEA 1CD2A 5DFRA 3JVXA 1DRHA 1OHJA 4X5FA 1HFRA 2C2TA 4KEBA 3QLWA 2XW7A 1IA2A 3IRNA 4NX7A 3ZPCA 4XT4A 5DXVA 5EAJA 4NX6A 4IXFX 2C2SA 3JWMA 1DG5A 4KNEA 1AI9A 2FZIA 4P3QA 3GI2A 2CD2A 2HM9A 6DFRA 2DHFA 3UM8A 3SA1A 3NXOA 1RB3A 4HOFA 3SQYX 3TD8A 2BLBA 2W9HA 1LUDA 3NTZA 1DREA 1S3UA 3RO9A 1LY4A 1RA2A 3FY9X 1RX5A 3EEMA 1DHJA 3JTWA 3HBBA 1IA4A 4KY4A 4M6JA 5HF2X 4P68A 1DRAA 3SRSX 2ANQA 3NZDA 3F8ZA 3FQCA 1DLRA 4KYAA 3FY8X 3F0SX 1TDRA 4X5JA 4FHBA 2H2QA 3I8AX 3FRFX 4FGHA 5FDAA 3FQOA 4LEKX 1DR4A 5HSUA 3SRQX 2O7PA 3JWKA 3QGTA 3OAFA 4FGGA 5JA3A 1RX6A 4P66A 1RA3A 1J3KA 2G6VA 1VJ3A 3LG4A 3JW3A 5U27A 5ECCA 5HT5A 4LAEX 3IX9A 4EIZA 1DYRA 1RX9A 4XT5A 1RA8A 4QLGA 3UM6A 3FL9A 3EIGA 1DG7A 3DATA 3TQBA 4HA7A 4QI9A 3CD2A 3FREX 3D80A 5HVEA 4OSGA 3K45A 4XECX 3GYFA 1U71A 3FQ0A 3QL0A 4QLFA 4DP3A 3M08A 3DL6A 3CL9A 4XE6X 1RF7A 1SEJA 3KGYA 1MVTA 1PD8A 1BOZA 1DR1A 1RX2A 2OIPA 4H96A 1JUVA 2HXVA 3DRCA 3GHVA 3OCHA 4Q0DA 4GH8A 3DGAA 3IRMA 1S3WA 3QLXA 1VDRA 1DYHA 1ZDRA 1DR6A 4DPHA 3NXVA 1HFQA 4Q0EA 3QLSA 2W9SA 2LF1A 1DRFA 1DR5A 1IA3A 3S7AA 4H98A 1DR2A 4DPDA 4G8ZX 3NXXA 2W3BA 3NZBX 4QJZD 4H95A 3EEKA 4PSTA 4QJCA 3L3RA 1RE7A 1U72A 3EELA 3QLRA 3F0XX 1HFPA 1RA9A 3FYVX 3FQFA 4KJKA 5CC9A 3GHWA 1S3YA 2BLAA 1RH3A 4HA9A 4Q6AA 3QFXA 2D5NA 3QLZA 1J3IA 4X5GA 5HUIA 2W9GA 3FQZA 1BZFA 4PTHA 3IA5A 1RC4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F0V X;  3JWF A;  2B3Z A;  5HVB A;  1KLK A;  3DL5 A;  4KY8 A;  4EJ1 A;  1RB2 A;  5HT4 A;  4CD2 A;  3FQV A;  3HJ3 A;  3SAI A;  3NXT A;  4KLX A;  2OBC A;  3I3R A;  4KJL A;  4KFJ A;  4M2X A;  3RG9 A;  4I13 A;  3VCO A;  1RX8 A;  2QK8 A;  1U70 A;  3QL3 A;  1DIS A;  4XRB A;  4G3M A;  3K2H A;  3NZC X;  1RX7 A;  3F91 A;  4IXG X;  3F0B X;  3EX8 A;  4X5H A;  3JWC A;  4PDJ A;  1DF7 A;  3DFR A;  2W9T A;  1RX1 A;  4G95 A;  1DYJ A;  4XT6 A;  4ELH A;  1RD7 A;  1DHF A;  4QHV A;  1M78 A;  3JW5 A;  1LY3 A;  1MVS A;  3KJS A;  3K74 A;  3CSE A;  1DDS A;  2P4G A;  3F0U X;  2W3V A;  3EEJ A;  4DDR A;  3SR5 X;  3QYL A;  3GHC A;  5CCC A;  4RGC A;  4XT8 A;  4ECK A;  1S3V A;  3D84 X;  4LAG X;  3Q1H A;  3S3V A;  4XT7 A;  1JOL A;  2BL9 A;  3FYW X;  3TQ9 A;  3SRR X;  3QYO A;  3ROA A;  1DR3 A;  5HQY A;  1JOM A;  2W3W A;  2W3M A;  1M79 A;  2ZZA A;  4LAH X;  4Q67 A;  1OHK A;  1KMS A;  3NZA X;  1E26 A;  4KBN A;  4OR7 A;  3SRU X;  3DG8 A;  3NZ6 X;  3F8Y A;  4KD7 A;  2INQ A;  3INV A;  3KY8 A;  1RX4 A;  1QZF A;  2L28 A;  2DRC A;  3FL8 A;  2FZH A;  3TQ8 A;  1YHO A;  4X5I A;  5HQZ A;  7DFR A;  1DR7 A;  3KFY A;  1DRB A;  4ELF A;  2ITH A;  1RA1 A;  1KMV A;  1M7A A;  3E0B A;  3SH2 A;  4KJJ A;  4H97 A;  4EIG A;  2CIG A;  3JSU A;  4IXE D;  1RG7 A;  2KGK A;  1DYI A;  1CZ3 A;  2GD9 A;  3ZPG A;  2HQP A;  5HPB A;  4DFR A;  4KM0 A;  1DDR A;  1DAJ A;  4TU5 X;  1AOE A;  4P3R A;  1AO8 A;  3NXY A;  4HOG A;  5HI6 A;  4ELG A;  2JYB A;  3FS6 A;  1PD9 A;  2W3A A;  3SRW X;  2D0K A;  3IRO A;  4M6K A;  5U26 A;  5JG0 X;  4ELB A;  1D1G A;  4PTJ A;  3FRD X;  4HOE A;  3UM5 A;  5E8Q A;  3CLB A;  4M7U A;  2FZJ A;  1J3J A;  5HSR A;  3NRR A;  4M7V A;  3K47 A;  1DIU A;  1DG8 A;  4M6L A;  1RX3 A;  3NZ9 X;  5ECX A;  4ELE A;  5HF0 X;  4I1N A;  1IA1 A;  3DAU A;  1PDB A;  3SGY A;  3F0Q X;  4PSS A;  1DHI A;  4EIL A;  3QLY A;  3NXR A;  8DFR A;  3IA4 A;  3FRA X;  2AZN A;  4PSY A;  3QG2 A;  3R33 A;  3M09 A;  4KM2 A;  3TQA A;  3KJR A;  4KL9 A;  3S9U A;  2BLC A;  4KAK A;  1DLS A;  3FRB X;  3SA2 A;  3N0H A;  2ANO A;  3NU0 A;  4QLE A;  1CD2 A;  5DFR A;  3JVX A;  1DRH A;  1OHJ A;  4X5F A;  1HFR A;  2C2T A;  4KEB A;  3QLW A;  2XW7 A;  1IA2 A;  3IRN A;  4NX7 A;  3ZPC A;  4XT4 A;  5DXV A;  5EAJ A;  4NX6 A;  4IXF X;  2C2S A;  3JWM A;  1DG5 A;  4KNE A;  1AI9 A;  2FZI A;  4P3Q A;  3GI2 A;  2CD2 A;  2HM9 A;  6DFR A;  2DHF A;  3UM8 A;  3SA1 A;  3NXO A;  1RB3 A;  4HOF A;  3SQY X;  3TD8 A;  2BLB A;  2W9H A;  1LUD A;  3NTZ A;  1DRE A;  1S3U A;  3RO9 A;  1LY4 A;  1RA2 A;  3FY9 X;  1RX5 A;  3EEM A;  1DHJ A;  3JTW A;  3HBB A;  1IA4 A;  4KY4 A;  4M6J A;  5HF2 X;  4P68 A;  1DRA A;  3SRS X;  2ANQ A;  3NZD A;  3F8Z A;  3FQC A;  1DLR A;  4KYA A;  3FY8 X;  3F0S X;  1TDR A;  4X5J A;  4FHB A;  2H2Q A;  3I8A X;  3FRF X;  4FGH A;  5FDA A;  3FQO A;  4LEK X;  1DR4 A;  5HSU A;  3SRQ X;  2O7P A;  3JWK A;  3QGT A;  3OAF A;  4FGG A;  5JA3 A;  1RX6 A;  4P66 A;  1RA3 A;  1J3K A;  2G6V A;  1VJ3 A;  3LG4 A;  3JW3 A;  5U27 A;  5ECC A;  5HT5 A;  4LAE X;  3IX9 A;  4EIZ A;  1DYR A;  1RX9 A;  4XT5 A;  1RA8 A;  4QLG A;  3UM6 A;  3FL9 A;  3EIG A;  1DG7 A;  3DAT A;  3TQB A;  4HA7 A;  4QI9 A;  3CD2 A;  3FRE X;  3D80 A;  5HVE A;  4OSG A;  3K45 A;  4XEC X;  3GYF A;  1U71 A;  3FQ0 A;  3QL0 A;  4QLF A;  4DP3 A;  3M08 A;  3DL6 A;  3CL9 A;  4XE6 X;  1RF7 A;  1SEJ A;  3KGY A;  1MVT A;  1PD8 A;  1BOZ A;  1DR1 A;  1RX2 A;  2OIP A;  4H96 A;  1JUV A;  2HXV A;  3DRC A;  3GHV A;  3OCH A;  4Q0D A;  4GH8 A;  3DGA A;  3IRM A;  1S3W A;  3QLX A;  1VDR A;  1DYH A;  1ZDR A;  1DR6 A;  4DPH A;  3NXV A;  1HFQ A;  4Q0E A;  3QLS A;  2W9S A;  2LF1 A;  1DRF A;  1DR5 A;  1IA3 A;  3S7A A;  4H98 A;  1DR2 A;  4DPD A;  4G8Z X;  3NXX A;  2W3B A;  3NZB X;  4QJZ D;  4H95 A;  3EEK A;  4PST A;  4QJC A;  3L3R A;  1RE7 A;  1U72 A;  3EEL A;  3QLR A;  3F0X X;  1HFP A;  1RA9 A;  3FYV X;  3FQF A;  4KJK A;  5CC9 A;  3GHW A;  1S3Y A;  2BLA A;  1RH3 A;  4HA9 A;  4Q6A A;  3QFX A;  2D5N A;  3QLZ A;  1J3I A;  4X5G A;  5HUI A;  2W9G A;  3FQZ A;  1BZF A;  4PTH A;  3IA5 A;  1RC4 A; 
#chains in the Genus database with same CATH topology
 3F0V X;  3JWF A;  2B3Z A;  5HVB A;  1KLK A;  3DL5 A;  4KY8 A;  4EJ1 A;  1RB2 A;  5HT4 A;  4CD2 A;  3FQV A;  3HJ3 A;  3SAI A;  3NXT A;  4KLX A;  2OBC A;  3I3R A;  4KJL A;  4KFJ A;  4M2X A;  3RG9 A;  4I13 A;  3VCO A;  1RX8 A;  2QK8 A;  1U70 A;  3QL3 A;  1DIS A;  4XRB A;  4G3M A;  3K2H A;  3NZC X;  1RX7 A;  3F91 A;  4IXG X;  3F0B X;  3EX8 A;  4X5H A;  3JWC A;  4PDJ A;  1DF7 A;  3DFR A;  2W9T A;  1RX1 A;  4G95 A;  1DYJ A;  4XT6 A;  4ELH A;  1RD7 A;  1DHF A;  4QHV A;  1M78 A;  3JW5 A;  1LY3 A;  1MVS A;  3KJS A;  3K74 A;  3CSE A;  1DDS A;  2P4G A;  3F0U X;  2W3V A;  3EEJ A;  4DDR A;  3SR5 X;  3QYL A;  3GHC A;  5CCC A;  4RGC A;  4XT8 A;  4ECK A;  1S3V A;  3D84 X;  4LAG X;  3Q1H A;  3S3V A;  4XT7 A;  1JOL A;  2BL9 A;  3FYW X;  3TQ9 A;  3SRR X;  3QYO A;  3ROA A;  1DR3 A;  5HQY A;  1JOM A;  2W3W A;  2W3M A;  1M79 A;  2ZZA A;  4LAH X;  4Q67 A;  1OHK A;  1KMS A;  3NZA X;  1E26 A;  4KBN A;  4OR7 A;  3SRU X;  3DG8 A;  3NZ6 X;  3F8Y A;  4KD7 A;  2INQ A;  3INV A;  3KY8 A;  1RX4 A;  1QZF A;  2L28 A;  2DRC A;  3FL8 A;  2FZH A;  3TQ8 A;  1YHO A;  4X5I A;  5HQZ A;  7DFR A;  1DR7 A;  3KFY A;  1DRB A;  4ELF A;  2ITH A;  1RA1 A;  1KMV A;  1M7A A;  3E0B A;  3SH2 A;  4KJJ A;  4H97 A;  4EIG A;  2CIG A;  3JSU A;  4IXE D;  1RG7 A;  2KGK A;  1DYI A;  1CZ3 A;  2GD9 A;  3ZPG A;  2HQP A;  5HPB A;  4DFR A;  4KM0 A;  1DDR A;  1DAJ A;  4TU5 X;  1AOE A;  4P3R A;  1AO8 A;  3NXY A;  4HOG A;  5HI6 A;  4ELG A;  2JYB A;  3FS6 A;  1PD9 A;  2W3A A;  3SRW X;  2D0K A;  3IRO A;  4M6K A;  5U26 A;  5JG0 X;  4ELB A;  1D1G A;  4PTJ A;  3FRD X;  4HOE A;  3UM5 A;  5E8Q A;  3CLB A;  4M7U A;  2FZJ A;  1J3J A;  5HSR A;  3NRR A;  4M7V A;  3K47 A;  1DIU A;  1DG8 A;  4M6L A;  1RX3 A;  3NZ9 X;  5ECX A;  4ELE A;  5HF0 X;  4I1N A;  1IA1 A;  3DAU A;  1PDB A;  3SGY A;  3F0Q X;  4PSS A;  1DHI A;  4EIL A;  3QLY A;  3NXR A;  8DFR A;  3IA4 A;  3FRA X;  2AZN A;  4PSY A;  3QG2 A;  3R33 A;  3M09 A;  4KM2 A;  3TQA A;  3KJR A;  4KL9 A;  3S9U A;  2BLC A;  4KAK A;  1DLS A;  3FRB X;  3SA2 A;  3N0H A;  2ANO A;  3NU0 A;  4QLE A;  1CD2 A;  5DFR A;  3JVX A;  1DRH A;  1OHJ A;  4X5F A;  1HFR A;  2C2T A;  4KEB A;  3QLW A;  2XW7 A;  1IA2 A;  3IRN A;  4NX7 A;  3ZPC A;  4XT4 A;  5DXV A;  5EAJ A;  4NX6 A;  4IXF X;  2C2S A;  3JWM A;  1DG5 A;  4KNE A;  1AI9 A;  2FZI A;  4P3Q A;  3GI2 A;  2CD2 A;  2HM9 A;  6DFR A;  2DHF A;  3UM8 A;  3SA1 A;  3NXO A;  1RB3 A;  4HOF A;  3SQY X;  3TD8 A;  2BLB A;  2W9H A;  1LUD A;  3NTZ A;  1DRE A;  1S3U A;  3RO9 A;  1LY4 A;  1RA2 A;  3FY9 X;  1RX5 A;  3EEM A;  1DHJ A;  3JTW A;  3HBB A;  1IA4 A;  4KY4 A;  4M6J A;  5HF2 X;  4P68 A;  1DRA A;  3SRS X;  2ANQ A;  3NZD A;  3F8Z A;  3FQC A;  1DLR A;  4KYA A;  3FY8 X;  3F0S X;  1TDR A;  4X5J A;  4FHB A;  2H2Q A;  3I8A X;  3FRF X;  4FGH A;  5FDA A;  3FQO A;  4LEK X;  1DR4 A;  5HSU A;  3SRQ X;  2O7P A;  3JWK A;  3QGT A;  3OAF A;  4FGG A;  5JA3 A;  1RX6 A;  4P66 A;  1RA3 A;  1J3K A;  2G6V A;  1VJ3 A;  3LG4 A;  3JW3 A;  5U27 A;  5ECC A;  5HT5 A;  4LAE X;  3IX9 A;  4EIZ A;  1DYR A;  1RX9 A;  4XT5 A;  1RA8 A;  4QLG A;  3UM6 A;  3FL9 A;  3EIG A;  1DG7 A;  3DAT A;  3TQB A;  4HA7 A;  4QI9 A;  3CD2 A;  3FRE X;  3D80 A;  5HVE A;  4OSG A;  3K45 A;  4XEC X;  3GYF A;  1U71 A;  3FQ0 A;  3QL0 A;  4QLF A;  4DP3 A;  3M08 A;  3DL6 A;  3CL9 A;  4XE6 X;  1RF7 A;  1SEJ A;  3KGY A;  1MVT A;  1PD8 A;  1BOZ A;  1DR1 A;  1RX2 A;  2OIP A;  4H96 A;  1JUV A;  2HXV A;  3DRC A;  3GHV A;  3OCH A;  4Q0D A;  4GH8 A;  3DGA A;  3IRM A;  1S3W A;  3QLX A;  1VDR A;  1DYH A;  1ZDR A;  1DR6 A;  4DPH A;  3NXV A;  1HFQ A;  4Q0E A;  3QLS A;  2W9S A;  2LF1 A;  1DRF A;  1DR5 A;  1IA3 A;  3S7A A;  4H98 A;  1DR2 A;  4DPD A;  4G8Z X;  3NXX A;  2W3B A;  3NZB X;  4QJZ D;  4H95 A;  3EEK A;  4PST A;  4QJC A;  3L3R A;  1RE7 A;  1U72 A;  3EEL A;  3QLR A;  3F0X X;  1HFP A;  1RA9 A;  3FYV X;  3FQF A;  4KJK A;  5CC9 A;  3GHW A;  1S3Y A;  2BLA A;  1RH3 A;  4HA9 A;  4Q6A A;  3QFX A;  2D5N A;  3QLZ A;  1J3I A;  4X5G A;  5HUI A;  2W9G A;  3FQZ A;  1BZF A;  4PTH A;  3IA5 A;  1RC4 A; 
#chains in the Genus database with same CATH homology
 3F0V X;  3JWF A;  2B3Z A;  5HVB A;  1KLK A;  3DL5 A;  4KY8 A;  4EJ1 A;  1RB2 A;  5HT4 A;  4CD2 A;  3FQV A;  3HJ3 A;  3SAI A;  3NXT A;  4KLX A;  2OBC A;  3I3R A;  4KJL A;  4KFJ A;  4M2X A;  3RG9 A;  4I13 A;  3VCO A;  1RX8 A;  2QK8 A;  1U70 A;  3QL3 A;  1DIS A;  4XRB A;  4G3M A;  3K2H A;  3NZC X;  1RX7 A;  3F91 A;  4IXG X;  3F0B X;  3EX8 A;  4X5H A;  3JWC A;  4PDJ A;  1DF7 A;  3DFR A;  2W9T A;  1RX1 A;  4G95 A;  1DYJ A;  4XT6 A;  4ELH A;  1RD7 A;  1DHF A;  4QHV A;  1M78 A;  3JW5 A;  1LY3 A;  1MVS A;  3KJS A;  3K74 A;  3CSE A;  1DDS A;  2P4G A;  3F0U X;  2W3V A;  3EEJ A;  4DDR A;  3SR5 X;  3QYL A;  3GHC A;  5CCC A;  4RGC A;  4XT8 A;  4ECK A;  1S3V A;  3D84 X;  4LAG X;  3Q1H A;  3S3V A;  4XT7 A;  1JOL A;  2BL9 A;  3FYW X;  3TQ9 A;  3SRR X;  3QYO A;  3ROA A;  1DR3 A;  5HQY A;  1JOM A;  2W3W A;  2W3M A;  1M79 A;  2ZZA A;  4LAH X;  4Q67 A;  1OHK A;  1KMS A;  3NZA X;  1E26 A;  4KBN A;  4OR7 A;  3SRU X;  3DG8 A;  3NZ6 X;  3F8Y A;  4KD7 A;  2INQ A;  3INV A;  3KY8 A;  1RX4 A;  1QZF A;  2L28 A;  2DRC A;  3FL8 A;  2FZH A;  3TQ8 A;  1YHO A;  4X5I A;  5HQZ A;  7DFR A;  1DR7 A;  3KFY A;  1DRB A;  4ELF A;  2ITH A;  1RA1 A;  1KMV A;  1M7A A;  3E0B A;  3SH2 A;  4KJJ A;  4H97 A;  4EIG A;  2CIG A;  3JSU A;  4IXE D;  1RG7 A;  2KGK A;  1DYI A;  1CZ3 A;  2GD9 A;  3ZPG A;  2HQP A;  5HPB A;  4DFR A;  4KM0 A;  1DDR A;  1DAJ A;  4TU5 X;  1AOE A;  4P3R A;  1AO8 A;  3NXY A;  4HOG A;  5HI6 A;  4ELG A;  2JYB A;  3FS6 A;  1PD9 A;  2W3A A;  3SRW X;  2D0K A;  3IRO A;  4M6K A;  5U26 A;  5JG0 X;  4ELB A;  1D1G A;  4PTJ A;  3FRD X;  4HOE A;  3UM5 A;  5E8Q A;  3CLB A;  4M7U A;  2FZJ A;  1J3J A;  5HSR A;  3NRR A;  4M7V A;  3K47 A;  1DIU A;  1DG8 A;  4M6L A;  1RX3 A;  3NZ9 X;  5ECX A;  4ELE A;  5HF0 X;  4I1N A;  1IA1 A;  3DAU A;  1PDB A;  3SGY A;  3F0Q X;  4PSS A;  1DHI A;  4EIL A;  3QLY A;  3NXR A;  8DFR A;  3IA4 A;  3FRA X;  2AZN A;  4PSY A;  3QG2 A;  3R33 A;  3M09 A;  4KM2 A;  3TQA A;  3KJR A;  4KL9 A;  3S9U A;  2BLC A;  4KAK A;  1DLS A;  3FRB X;  3SA2 A;  3N0H A;  2ANO A;  3NU0 A;  4QLE A;  1CD2 A;  5DFR A;  3JVX A;  1DRH A;  1OHJ A;  4X5F A;  1HFR A;  2C2T A;  4KEB A;  3QLW A;  2XW7 A;  1IA2 A;  3IRN A;  4NX7 A;  3ZPC A;  4XT4 A;  5DXV A;  5EAJ A;  4NX6 A;  4IXF X;  2C2S A;  3JWM A;  1DG5 A;  4KNE A;  1AI9 A;  2FZI A;  4P3Q A;  3GI2 A;  2CD2 A;  2HM9 A;  6DFR A;  2DHF A;  3UM8 A;  3SA1 A;  3NXO A;  1RB3 A;  4HOF A;  3SQY X;  3TD8 A;  2BLB A;  2W9H A;  1LUD A;  3NTZ A;  1DRE A;  1S3U A;  3RO9 A;  1LY4 A;  1RA2 A;  3FY9 X;  1RX5 A;  3EEM A;  1DHJ A;  3JTW A;  3HBB A;  1IA4 A;  4KY4 A;  4M6J A;  5HF2 X;  4P68 A;  1DRA A;  3SRS X;  2ANQ A;  3NZD A;  3F8Z A;  3FQC A;  1DLR A;  4KYA A;  3FY8 X;  3F0S X;  1TDR A;  4X5J A;  4FHB A;  2H2Q A;  3I8A X;  3FRF X;  4FGH A;  5FDA A;  3FQO A;  4LEK X;  1DR4 A;  5HSU A;  3SRQ X;  2O7P A;  3JWK A;  3QGT A;  3OAF A;  4FGG A;  5JA3 A;  1RX6 A;  4P66 A;  1RA3 A;  1J3K A;  2G6V A;  1VJ3 A;  3LG4 A;  3JW3 A;  5U27 A;  5ECC A;  5HT5 A;  4LAE X;  3IX9 A;  4EIZ A;  1DYR A;  1RX9 A;  4XT5 A;  1RA8 A;  4QLG A;  3UM6 A;  3FL9 A;  3EIG A;  1DG7 A;  3DAT A;  3TQB A;  4HA7 A;  4QI9 A;  3CD2 A;  3FRE X;  3D80 A;  5HVE A;  4OSG A;  3K45 A;  4XEC X;  3GYF A;  1U71 A;  3FQ0 A;  3QL0 A;  4QLF A;  4DP3 A;  3M08 A;  3DL6 A;  3CL9 A;  4XE6 X;  1RF7 A;  1SEJ A;  3KGY A;  1MVT A;  1PD8 A;  1BOZ A;  1DR1 A;  1RX2 A;  2OIP A;  4H96 A;  1JUV A;  2HXV A;  3DRC A;  3GHV A;  3OCH A;  4Q0D A;  4GH8 A;  3DGA A;  3IRM A;  1S3W A;  3QLX A;  1VDR A;  1DYH A;  1ZDR A;  1DR6 A;  4DPH A;  3NXV A;  1HFQ A;  4Q0E A;  3QLS A;  2W9S A;  2LF1 A;  1DRF A;  1DR5 A;  1IA3 A;  3S7A A;  4H98 A;  1DR2 A;  4DPD A;  4G8Z X;  3NXX A;  2W3B A;  3NZB X;  4QJZ D;  4H95 A;  3EEK A;  4PST A;  4QJC A;  3L3R A;  1RE7 A;  1U72 A;  3EEL A;  3QLR A;  3F0X X;  1HFP A;  1RA9 A;  3FYV X;  3FQF A;  4KJK A;  5CC9 A;  3GHW A;  1S3Y A;  2BLA A;  1RH3 A;  4HA9 A;  4Q6A A;  3QFX A;  2D5N A;  3QLZ A;  1J3I A;  4X5G A;  5HUI A;  2W9G A;  3FQZ A;  1BZF A;  4PTH A;  3IA5 A;  1RC4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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