3FS6A

Correlations of inhibitor kinetics for pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 54
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3fs6A00
1RX3A 3NXTA 3TQBA 4LAEX 1IA1A 5E8QA 3NXXA 2W9TA 3QFXA 4KBNA 1VDRA 1PDBA 1IA4A 3FYWX 4P68A 4DPHA 4EILA 1RB2A 3VCOA 4QLGA 5FDAA 3NXYA 3KJSA 5HVEA 4I1NA 3FL9A 4HOEA 3GHVA 5HI6A 1JUVA 3SRWX 4EIGA 2BLBA 2HQPA 3KGYA 3CL9A 4KLXA 4NX6A 3IA5A 3QLYA 1RX5A 2W3VA 2HXVA 3CD2A 3CLBA 3FQVA 2ANOA 1OHKA 2W3BA 1TDRA 3M09A 5EAJA 4FGHA 3DAUA 3QL0A 1DLRA 1CZ3A 1RX7A 1DR6A 1BOZA 1SEJA 2JYBA 1RA2A 4PSYA 4HA9A 4TU5X 1DRBA 1RC4A 1DHFA 1RX8A 1IA2A 5HF0X 4XECX 2C2TA 4KM0A 5U27A 3JSUA 3NZAX 1RX1A 4H97A 4IXGX 4QJZD 4KY8A 8DFRA 3IRNA 1VJ3A 4ECKA 1LY3A 4LEKX 4EJ1A 2CD2A 1M7AA 1CD2A 4KL9A 4I13A 4ELBA 1RE7A 1RA9A 3GHWA 1DR7A 2AZNA 3EELA 2BLAA 3R33A 3S9UA 3KJRA 5HPBA 3K45A 1DF7A 2ZZAA 3K47A 4RGCA 4IXFX 4KAKA 1DYRA 5HQYA 2INQA 2BL9A 3QLXA 1DAJA 3DG8A 3FRDX 2DRCA 1KMVA 2D0KA 4Q0EA 4KJKA 1MVTA 4P3QA 1BZFA 2C2SA 1DRFA 3N0HA 3FY9X 3SQYX 3DRCA 3NZCX 5HF2X 5CC9A 3TQAA 1ZDRA 3F0SX 3NU0A 3F0XX 2D5NA 1PD8A 4XT8A 1JOMA 1KMSA 1AO8A 4HA7A 4PDJA 3FRBX 4XT5A 1U71A 5U26A 1M78A 3TQ9A 1DG8A 1S3YA 3IX9A 4X5JA 1S3VA 4M7VA 4KY4A 4Q0DA 4Q67A 4DP3A 4ELGA 3DGAA 4M6JA 3GI2A 4FHBA 2HM9A 3NRRA 3FL8A 3QG2A 3GYFA 4M6LA 3NZ9X 3ROAA 3JWMA 3I8AX 3SGYA 3SRQX 3ZPCA 3DFRA 2GD9A 5DXVA 3EIGA 1J3JA 4KM2A 2W3MA 4P66A 1M79A 1DR1A 4PTHA 3NXRA 3KY8A 3QYOA 3OAFA 3FQZA 1RD7A 1HFRA 3SRUX 3S3VA 3JWKA 3RG9A 3QL3A 3EEJA 3FRAX 2W3WA 3JW3A 3FRFX 3NZBX 2W3AA 3FREX 3QLWA 4KD7A 3EEMA 2B3ZA 3UM8A 1DYHA 3K2HA 1DRHA 4EIZA 4G95A 1DDSA 2ITHA 4KFJA 1J3KA 1RB3A 3QLSA 3DL5A 4H96A 3F0QX 4NX7A 4QI9A 4HOFA 1DHIA 1U70A 7DFRA 3NXOA 1YHOA 4Q6AA 3KFYA 4X5HA 3TD8A 1JOLA 5HUIA 2W9HA 3NTZA 3F91A 5JA3A 3I3RA 4QHVA 3SRRX 3S7AA 1MVSA 4LAHX 4KJLA 3F0BX 3F0UX 2W9GA 1DYJA 4DDRA 4XE6X 1RX4A 3EX8A 5HT4A 3INVA 1RX2A 4P3RA 1LY4A 3ZPGA 4XT6A 3NZ6X 3E0BA 4M7UA 1RX6A 4X5FA 4OR7A 1RA3A 1LUDA 2L28A 2W9SA 3M08A 2XW7A 4GH8A 1HFQA 3LG4A 4QLEA 4G8ZX 1J3IA 4IXED 1DR4A 1DDRA 1RG7A 4QLFA 1RF7A 3FY8X 4QJCA 1IA3A 4H95A 3UM5A 4H98A 3SRSX 1DREA 3HJ3A 3DATA 3F8YA 4FGGA 3FQCA 4CD2A 3IROA 4ELEA 3RO9A 1DR3A 3UM6A 6DFRA 2LF1A 3QGTA 3OCHA 5ECCA 1DISA 3SR5X 2CIGA 5CCCA 3NXVA 1AOEA 3SA2A 3JVXA 1DYIA 3K74A 2OBCA 2QK8A 3QYLA 1U72A 2P4GA 1S3UA 3SAIA 3TQ8A 2O7PA 1QZFA 3CSEA 4X5GA 1DG7A 3EEKA 4OSGA 5ECXA 1OHJA 1HFPA 3JWFA 3Q1HA 2KGKA 1AI9A 4XT7A 3JTWA 4XRBA 3D80A 3DL6A 4G3MA 4ELFA 3QLRA 3FQOA 1DRAA 4HOGA 1DHJA 4KJJA 4PSSA 2FZIA 2FZHA 2OIPA 5HQZA 3F0VX 4ELHA 4PSTA 2FZJA 4KEBA 5HVBA 3NZDA 1PD9A 4LAGX 3FQ0A 2G6VA 2BLCA 3FYVX 1RA1A 4XT4A 3F8ZA 4KYAA 3IA4A 5DFRA 1DLSA 4PTJA 2DHFA 5JG0X 5HSRA 5HT5A 1E26A 3FS6A 4X5IA 3QLZA 1RH3A 3GHCA 3SH2A 1S3WA 2H2QA 3IRMA 5HSUA 1DG5A 2ANQA 1D1GA 1DR5A 3L3RA 3JW5A 3JWCA 3HBBA 3D84X 3FQFA 3SA1A 1DR2A 4DFRA 1DIUA 1RA8A 1KLKA 4M6KA 1RX9A 4KNEA 4M2XA 4DPDA
chains in the Genus database with same CATH superfamily
1RX3A 3NXTA 3TQBA 4LAEX 1IA1A 5E8QA 3NXXA 2W9TA 3QFXA 4KBNA 1VDRA 1PDBA 1IA4A 3FYWX 4P68A 4DPHA 4EILA 1RB2A 3VCOA 4QLGA 5FDAA 3NXYA 3KJSA 5HVEA 4I1NA 3FL9A 4HOEA 3GHVA 5HI6A 1JUVA 3SRWX 4EIGA 2BLBA 2HQPA 3KGYA 3CL9A 4KLXA 4NX6A 3IA5A 3QLYA 1RX5A 2W3VA 2HXVA 3CD2A 3CLBA 3FQVA 2ANOA 1OHKA 2W3BA 1TDRA 3M09A 5EAJA 4FGHA 3DAUA 3QL0A 1DLRA 1CZ3A 1RX7A 1DR6A 1BOZA 1SEJA 2JYBA 1RA2A 4PSYA 4HA9A 4TU5X 1DRBA 1RC4A 1DHFA 1RX8A 1IA2A 5HF0X 4XECX 2C2TA 4KM0A 5U27A 3JSUA 3NZAX 1RX1A 4H97A 4IXGX 4QJZD 4KY8A 8DFRA 3IRNA 1VJ3A 4ECKA 1LY3A 4LEKX 4EJ1A 2CD2A 1M7AA 1CD2A 4KL9A 4I13A 4ELBA 1RE7A 1RA9A 3GHWA 1DR7A 2AZNA 3EELA 2BLAA 3R33A 3S9UA 3KJRA 5HPBA 3K45A 1DF7A 2ZZAA 3K47A 4RGCA 4IXFX 4KAKA 1DYRA 5HQYA 2INQA 2BL9A 3QLXA 1DAJA 3DG8A 3FRDX 2DRCA 1KMVA 2D0KA 4Q0EA 4KJKA 1MVTA 4P3QA 1BZFA 2C2SA 1DRFA 3N0HA 3FY9X 3SQYX 3DRCA 3NZCX 5HF2X 5CC9A 3TQAA 1ZDRA 3F0SX 3NU0A 3F0XX 2D5NA 1PD8A 4XT8A 1JOMA 1KMSA 1AO8A 4HA7A 4PDJA 3FRBX 4XT5A 1U71A 5U26A 1M78A 3TQ9A 1DG8A 1S3YA 3IX9A 4X5JA 1S3VA 4M7VA 4KY4A 4Q0DA 4Q67A 4DP3A 4ELGA 3DGAA 4M6JA 3GI2A 4FHBA 2HM9A 3NRRA 3FL8A 3QG2A 3GYFA 4M6LA 3NZ9X 3ROAA 3JWMA 3I8AX 3SGYA 3SRQX 3ZPCA 3DFRA 2GD9A 5DXVA 3EIGA 1J3JA 4KM2A 2W3MA 4P66A 1M79A 1DR1A 4PTHA 3NXRA 3KY8A 3QYOA 3OAFA 3FQZA 1RD7A 1HFRA 3SRUX 3S3VA 3JWKA 3RG9A 3QL3A 3EEJA 3FRAX 2W3WA 3JW3A 3FRFX 3NZBX 2W3AA 3FREX 3QLWA 4KD7A 3EEMA 2B3ZA 3UM8A 1DYHA 3K2HA 1DRHA 4EIZA 4G95A 1DDSA 2ITHA 4KFJA 1J3KA 1RB3A 3QLSA 3DL5A 4H96A 3F0QX 4NX7A 4QI9A 4HOFA 1DHIA 1U70A 7DFRA 3NXOA 1YHOA 4Q6AA 3KFYA 4X5HA 3TD8A 1JOLA 5HUIA 2W9HA 3NTZA 3F91A 5JA3A 3I3RA 4QHVA 3SRRX 3S7AA 1MVSA 4LAHX 4KJLA 3F0BX 3F0UX 2W9GA 1DYJA 4DDRA 4XE6X 1RX4A 3EX8A 5HT4A 3INVA 1RX2A 4P3RA 1LY4A 3ZPGA 4XT6A 3NZ6X 3E0BA 4M7UA 1RX6A 4X5FA 4OR7A 1RA3A 1LUDA 2L28A 2W9SA 3M08A 2XW7A 4GH8A 1HFQA 3LG4A 4QLEA 4G8ZX 1J3IA 4IXED 1DR4A 1DDRA 1RG7A 4QLFA 1RF7A 3FY8X 4QJCA 1IA3A 4H95A 3UM5A 4H98A 3SRSX 1DREA 3HJ3A 3DATA 3F8YA 4FGGA 3FQCA 4CD2A 3IROA 4ELEA 3RO9A 1DR3A 3UM6A 6DFRA 2LF1A 3QGTA 3OCHA 5ECCA 1DISA 3SR5X 2CIGA 5CCCA 3NXVA 1AOEA 3SA2A 3JVXA 1DYIA 3K74A 2OBCA 2QK8A 3QYLA 1U72A 2P4GA 1S3UA 3SAIA 3TQ8A 2O7PA 1QZFA 3CSEA 4X5GA 1DG7A 3EEKA 4OSGA 5ECXA 1OHJA 1HFPA 3JWFA 3Q1HA 2KGKA 1AI9A 4XT7A 3JTWA 4XRBA 3D80A 3DL6A 4G3MA 4ELFA 3QLRA 3FQOA 1DRAA 4HOGA 1DHJA 4KJJA 4PSSA 2FZIA 2FZHA 2OIPA 5HQZA 3F0VX 4ELHA 4PSTA 2FZJA 4KEBA 5HVBA 3NZDA 1PD9A 4LAGX 3FQ0A 2G6VA 2BLCA 3FYVX 1RA1A 4XT4A 3F8ZA 4KYAA 3IA4A 5DFRA 1DLSA 4PTJA 2DHFA 5JG0X 5HSRA 5HT5A 1E26A 3FS6A 4X5IA 3QLZA 1RH3A 3GHCA 3SH2A 1S3WA 2H2QA 3IRMA 5HSUA 1DG5A 2ANQA 1D1GA 1DR5A 3L3RA 3JW5A 3JWCA 3HBBA 3D84X 3FQFA 3SA1A 1DR2A 4DFRA 1DIUA 1RA8A 1KLKA 4M6KA 1RX9A 4KNEA 4M2XA 4DPDA
chains in the Genus database with same CATH topology
1RX3A 3NXTA 3TQBA 4LAEX 1IA1A 5E8QA 3NXXA 2W9TA 3QFXA 4KBNA 1VDRA 1PDBA 1IA4A 3FYWX 4P68A 4DPHA 4EILA 1RB2A 3VCOA 4QLGA 5FDAA 3NXYA 3KJSA 5HVEA 4I1NA 3FL9A 4HOEA 3GHVA 5HI6A 1JUVA 3SRWX 4EIGA 2BLBA 2HQPA 3KGYA 3CL9A 4KLXA 4NX6A 3IA5A 3QLYA 1RX5A 2W3VA 2HXVA 3CD2A 3CLBA 3FQVA 2ANOA 1OHKA 2W3BA 1TDRA 3M09A 5EAJA 4FGHA 3DAUA 3QL0A 1DLRA 1CZ3A 1RX7A 1DR6A 1BOZA 1SEJA 2JYBA 1RA2A 4PSYA 4HA9A 4TU5X 1DRBA 1RC4A 1DHFA 1RX8A 1IA2A 5HF0X 4XECX 2C2TA 4KM0A 5U27A 3JSUA 3NZAX 1RX1A 4H97A 4IXGX 4QJZD 4KY8A 8DFRA 3IRNA 1VJ3A 4ECKA 1LY3A 4LEKX 4EJ1A 2CD2A 1M7AA 1CD2A 4KL9A 4I13A 4ELBA 1RE7A 1RA9A 3GHWA 1DR7A 2AZNA 3EELA 2BLAA 3R33A 3S9UA 3KJRA 5HPBA 3K45A 1DF7A 2ZZAA 3K47A 4RGCA 4IXFX 4KAKA 1DYRA 5HQYA 2INQA 2BL9A 3QLXA 1DAJA 3DG8A 3FRDX 2DRCA 1KMVA 2D0KA 4Q0EA 4KJKA 1MVTA 4P3QA 1BZFA 2C2SA 1DRFA 3N0HA 3FY9X 3SQYX 3DRCA 3NZCX 5HF2X 5CC9A 3TQAA 1ZDRA 3F0SX 3NU0A 3F0XX 2D5NA 1PD8A 4XT8A 1JOMA 1KMSA 1AO8A 4HA7A 4PDJA 3FRBX 4XT5A 1U71A 5U26A 1M78A 3TQ9A 1DG8A 1S3YA 3IX9A 4X5JA 1S3VA 4M7VA 4KY4A 4Q0DA 4Q67A 4DP3A 4ELGA 3DGAA 4M6JA 3GI2A 4FHBA 2HM9A 3NRRA 3FL8A 3QG2A 3GYFA 4M6LA 3NZ9X 3ROAA 3JWMA 3I8AX 3SGYA 3SRQX 3ZPCA 3DFRA 2GD9A 5DXVA 3EIGA 1J3JA 4KM2A 2W3MA 4P66A 1M79A 1DR1A 4PTHA 3NXRA 3KY8A 3QYOA 3OAFA 3FQZA 1RD7A 1HFRA 3SRUX 3S3VA 3JWKA 3RG9A 3QL3A 3EEJA 3FRAX 2W3WA 3JW3A 3FRFX 3NZBX 2W3AA 3FREX 3QLWA 4KD7A 3EEMA 2B3ZA 3UM8A 1DYHA 3K2HA 1DRHA 4EIZA 4G95A 1DDSA 2ITHA 4KFJA 1J3KA 1RB3A 3QLSA 3DL5A 4H96A 3F0QX 4NX7A 4QI9A 4HOFA 1DHIA 1U70A 7DFRA 3NXOA 1YHOA 4Q6AA 3KFYA 4X5HA 3TD8A 1JOLA 5HUIA 2W9HA 3NTZA 3F91A 5JA3A 3I3RA 4QHVA 3SRRX 3S7AA 1MVSA 4LAHX 4KJLA 3F0BX 3F0UX 2W9GA 1DYJA 4DDRA 4XE6X 1RX4A 3EX8A 5HT4A 3INVA 1RX2A 4P3RA 1LY4A 3ZPGA 4XT6A 3NZ6X 3E0BA 4M7UA 1RX6A 4X5FA 4OR7A 1RA3A 1LUDA 2L28A 2W9SA 3M08A 2XW7A 4GH8A 1HFQA 3LG4A 4QLEA 4G8ZX 1J3IA 4IXED 1DR4A 1DDRA 1RG7A 4QLFA 1RF7A 3FY8X 4QJCA 1IA3A 4H95A 3UM5A 4H98A 3SRSX 1DREA 3HJ3A 3DATA 3F8YA 4FGGA 3FQCA 4CD2A 3IROA 4ELEA 3RO9A 1DR3A 3UM6A 6DFRA 2LF1A 3QGTA 3OCHA 5ECCA 1DISA 3SR5X 2CIGA 5CCCA 3NXVA 1AOEA 3SA2A 3JVXA 1DYIA 3K74A 2OBCA 2QK8A 3QYLA 1U72A 2P4GA 1S3UA 3SAIA 3TQ8A 2O7PA 1QZFA 3CSEA 4X5GA 1DG7A 3EEKA 4OSGA 5ECXA 1OHJA 1HFPA 3JWFA 3Q1HA 2KGKA 1AI9A 4XT7A 3JTWA 4XRBA 3D80A 3DL6A 4G3MA 4ELFA 3QLRA 3FQOA 1DRAA 4HOGA 1DHJA 4KJJA 4PSSA 2FZIA 2FZHA 2OIPA 5HQZA 3F0VX 4ELHA 4PSTA 2FZJA 4KEBA 5HVBA 3NZDA 1PD9A 4LAGX 3FQ0A 2G6VA 2BLCA 3FYVX 1RA1A 4XT4A 3F8ZA 4KYAA 3IA4A 5DFRA 1DLSA 4PTJA 2DHFA 5JG0X 5HSRA 5HT5A 1E26A 3FS6A 4X5IA 3QLZA 1RH3A 3GHCA 3SH2A 1S3WA 2H2QA 3IRMA 5HSUA 1DG5A 2ANQA 1D1GA 1DR5A 3L3RA 3JW5A 3JWCA 3HBBA 3D84X 3FQFA 3SA1A 1DR2A 4DFRA 1DIUA 1RA8A 1KLKA 4M6KA 1RX9A 4KNEA 4M2XA 4DPDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RX3 A;  3NXT A;  3TQB A;  4LAE X;  1IA1 A;  5E8Q A;  3NXX A;  2W9T A;  3QFX A;  4KBN A;  1VDR A;  1PDB A;  1IA4 A;  3FYW X;  4P68 A;  4DPH A;  4EIL A;  1RB2 A;  3VCO A;  4QLG A;  5FDA A;  3NXY A;  3KJS A;  5HVE A;  4I1N A;  3FL9 A;  4HOE A;  3GHV A;  5HI6 A;  1JUV A;  3SRW X;  4EIG A;  2BLB A;  2HQP A;  3KGY A;  3CL9 A;  4KLX A;  4NX6 A;  3IA5 A;  3QLY A;  1RX5 A;  2W3V A;  2HXV A;  3CD2 A;  3CLB A;  3FQV A;  2ANO A;  1OHK A;  2W3B A;  1TDR A;  3M09 A;  5EAJ A;  4FGH A;  3DAU A;  3QL0 A;  1DLR A;  1CZ3 A;  1RX7 A;  1DR6 A;  1BOZ A;  1SEJ A;  2JYB A;  1RA2 A;  4PSY A;  4HA9 A;  4TU5 X;  1DRB A;  1RC4 A;  1DHF A;  1RX8 A;  1IA2 A;  5HF0 X;  4XEC X;  2C2T A;  4KM0 A;  5U27 A;  3JSU A;  3NZA X;  1RX1 A;  4H97 A;  4IXG X;  4QJZ D;  4KY8 A;  8DFR A;  3IRN A;  1VJ3 A;  4ECK A;  1LY3 A;  4LEK X;  4EJ1 A;  2CD2 A;  1M7A A;  1CD2 A;  4KL9 A;  4I13 A;  4ELB A;  1RE7 A;  1RA9 A;  3GHW A;  1DR7 A;  2AZN A;  3EEL A;  2BLA A;  3R33 A;  3S9U A;  3KJR A;  5HPB A;  3K45 A;  1DF7 A;  2ZZA A;  3K47 A;  4RGC A;  4IXF X;  4KAK A;  1DYR A;  5HQY A;  2INQ A;  2BL9 A;  3QLX A;  1DAJ A;  3DG8 A;  3FRD X;  2DRC A;  1KMV A;  2D0K A;  4Q0E A;  4KJK A;  1MVT A;  4P3Q A;  1BZF A;  2C2S A;  1DRF A;  3N0H A;  3FY9 X;  3SQY X;  3DRC A;  3NZC X;  5HF2 X;  5CC9 A;  3TQA A;  1ZDR A;  3F0S X;  3NU0 A;  3F0X X;  2D5N A;  1PD8 A;  4XT8 A;  1JOM A;  1KMS A;  1AO8 A;  4HA7 A;  4PDJ A;  3FRB X;  4XT5 A;  1U71 A;  5U26 A;  1M78 A;  3TQ9 A;  1DG8 A;  1S3Y A;  3IX9 A;  4X5J A;  1S3V A;  4M7V A;  4KY4 A;  4Q0D A;  4Q67 A;  4DP3 A;  4ELG A;  3DGA A;  4M6J A;  3GI2 A;  4FHB A;  2HM9 A;  3NRR A;  3FL8 A;  3QG2 A;  3GYF A;  4M6L A;  3NZ9 X;  3ROA A;  3JWM A;  3I8A X;  3SGY A;  3SRQ X;  3ZPC A;  3DFR A;  2GD9 A;  5DXV A;  3EIG A;  1J3J A;  4KM2 A;  2W3M A;  4P66 A;  1M79 A;  1DR1 A;  4PTH A;  3NXR A;  3KY8 A;  3QYO A;  3OAF A;  3FQZ A;  1RD7 A;  1HFR A;  3SRU X;  3S3V A;  3JWK A;  3RG9 A;  3QL3 A;  3EEJ A;  3FRA X;  2W3W A;  3JW3 A;  3FRF X;  3NZB X;  2W3A A;  3FRE X;  3QLW A;  4KD7 A;  3EEM A;  2B3Z A;  3UM8 A;  1DYH A;  3K2H A;  1DRH A;  4EIZ A;  4G95 A;  1DDS A;  2ITH A;  4KFJ A;  1J3K A;  1RB3 A;  3QLS A;  3DL5 A;  4H96 A;  3F0Q X;  4NX7 A;  4QI9 A;  4HOF A;  1DHI A;  1U70 A;  7DFR A;  3NXO A;  1YHO A;  4Q6A A;  3KFY A;  4X5H A;  3TD8 A;  1JOL A;  5HUI A;  2W9H A;  3NTZ A;  3F91 A;  5JA3 A;  3I3R A;  4QHV A;  3SRR X;  3S7A A;  1MVS A;  4LAH X;  4KJL A;  3F0B X;  3F0U X;  2W9G A;  1DYJ A;  4DDR A;  4XE6 X;  1RX4 A;  3EX8 A;  5HT4 A;  3INV A;  1RX2 A;  4P3R A;  1LY4 A;  3ZPG A;  4XT6 A;  3NZ6 X;  3E0B A;  4M7U A;  1RX6 A;  4X5F A;  4OR7 A;  1RA3 A;  1LUD A;  2L28 A;  2W9S A;  3M08 A;  2XW7 A;  4GH8 A;  1HFQ A;  3LG4 A;  4QLE A;  4G8Z X;  1J3I A;  4IXE D;  1DR4 A;  1DDR A;  1RG7 A;  4QLF A;  1RF7 A;  3FY8 X;  4QJC A;  1IA3 A;  4H95 A;  3UM5 A;  4H98 A;  3SRS X;  1DRE A;  3HJ3 A;  3DAT A;  3F8Y A;  4FGG A;  3FQC A;  4CD2 A;  3IRO A;  4ELE A;  3RO9 A;  1DR3 A;  3UM6 A;  6DFR A;  2LF1 A;  3QGT A;  3OCH A;  5ECC A;  1DIS A;  3SR5 X;  2CIG A;  5CCC A;  3NXV A;  1AOE A;  3SA2 A;  3JVX A;  1DYI A;  3K74 A;  2OBC A;  2QK8 A;  3QYL A;  1U72 A;  2P4G A;  1S3U A;  3SAI A;  3TQ8 A;  2O7P A;  1QZF A;  3CSE A;  4X5G A;  1DG7 A;  3EEK A;  4OSG A;  5ECX A;  1OHJ A;  1HFP A;  3JWF A;  3Q1H A;  2KGK A;  1AI9 A;  4XT7 A;  3JTW A;  4XRB A;  3D80 A;  3DL6 A;  4G3M A;  4ELF A;  3QLR A;  3FQO A;  1DRA A;  4HOG A;  1DHJ A;  4KJJ A;  4PSS A;  2FZI A;  2FZH A;  2OIP A;  5HQZ A;  3F0V X;  4ELH A;  4PST A;  2FZJ A;  4KEB A;  5HVB A;  3NZD A;  1PD9 A;  4LAG X;  3FQ0 A;  2G6V A;  2BLC A;  3FYV X;  1RA1 A;  4XT4 A;  3F8Z A;  4KYA A;  3IA4 A;  5DFR A;  1DLS A;  4PTJ A;  2DHF A;  5JG0 X;  5HSR A;  5HT5 A;  1E26 A;  3FS6 A;  4X5I A;  3QLZ A;  1RH3 A;  3GHC A;  3SH2 A;  1S3W A;  2H2Q A;  3IRM A;  5HSU A;  1DG5 A;  2ANQ A;  1D1G A;  1DR5 A;  3L3R A;  3JW5 A;  3JWC A;  3HBB A;  3D84 X;  3FQF A;  3SA1 A;  1DR2 A;  4DFR A;  1DIU A;  1RA8 A;  1KLK A;  4M6K A;  1RX9 A;  4KNE A;  4M2X A;  4DPD A; 
#chains in the Genus database with same CATH topology
 1RX3 A;  3NXT A;  3TQB A;  4LAE X;  1IA1 A;  5E8Q A;  3NXX A;  2W9T A;  3QFX A;  4KBN A;  1VDR A;  1PDB A;  1IA4 A;  3FYW X;  4P68 A;  4DPH A;  4EIL A;  1RB2 A;  3VCO A;  4QLG A;  5FDA A;  3NXY A;  3KJS A;  5HVE A;  4I1N A;  3FL9 A;  4HOE A;  3GHV A;  5HI6 A;  1JUV A;  3SRW X;  4EIG A;  2BLB A;  2HQP A;  3KGY A;  3CL9 A;  4KLX A;  4NX6 A;  3IA5 A;  3QLY A;  1RX5 A;  2W3V A;  2HXV A;  3CD2 A;  3CLB A;  3FQV A;  2ANO A;  1OHK A;  2W3B A;  1TDR A;  3M09 A;  5EAJ A;  4FGH A;  3DAU A;  3QL0 A;  1DLR A;  1CZ3 A;  1RX7 A;  1DR6 A;  1BOZ A;  1SEJ A;  2JYB A;  1RA2 A;  4PSY A;  4HA9 A;  4TU5 X;  1DRB A;  1RC4 A;  1DHF A;  1RX8 A;  1IA2 A;  5HF0 X;  4XEC X;  2C2T A;  4KM0 A;  5U27 A;  3JSU A;  3NZA X;  1RX1 A;  4H97 A;  4IXG X;  4QJZ D;  4KY8 A;  8DFR A;  3IRN A;  1VJ3 A;  4ECK A;  1LY3 A;  4LEK X;  4EJ1 A;  2CD2 A;  1M7A A;  1CD2 A;  4KL9 A;  4I13 A;  4ELB A;  1RE7 A;  1RA9 A;  3GHW A;  1DR7 A;  2AZN A;  3EEL A;  2BLA A;  3R33 A;  3S9U A;  3KJR A;  5HPB A;  3K45 A;  1DF7 A;  2ZZA A;  3K47 A;  4RGC A;  4IXF X;  4KAK A;  1DYR A;  5HQY A;  2INQ A;  2BL9 A;  3QLX A;  1DAJ A;  3DG8 A;  3FRD X;  2DRC A;  1KMV A;  2D0K A;  4Q0E A;  4KJK A;  1MVT A;  4P3Q A;  1BZF A;  2C2S A;  1DRF A;  3N0H A;  3FY9 X;  3SQY X;  3DRC A;  3NZC X;  5HF2 X;  5CC9 A;  3TQA A;  1ZDR A;  3F0S X;  3NU0 A;  3F0X X;  2D5N A;  1PD8 A;  4XT8 A;  1JOM A;  1KMS A;  1AO8 A;  4HA7 A;  4PDJ A;  3FRB X;  4XT5 A;  1U71 A;  5U26 A;  1M78 A;  3TQ9 A;  1DG8 A;  1S3Y A;  3IX9 A;  4X5J A;  1S3V A;  4M7V A;  4KY4 A;  4Q0D A;  4Q67 A;  4DP3 A;  4ELG A;  3DGA A;  4M6J A;  3GI2 A;  4FHB A;  2HM9 A;  3NRR A;  3FL8 A;  3QG2 A;  3GYF A;  4M6L A;  3NZ9 X;  3ROA A;  3JWM A;  3I8A X;  3SGY A;  3SRQ X;  3ZPC A;  3DFR A;  2GD9 A;  5DXV A;  3EIG A;  1J3J A;  4KM2 A;  2W3M A;  4P66 A;  1M79 A;  1DR1 A;  4PTH A;  3NXR A;  3KY8 A;  3QYO A;  3OAF A;  3FQZ A;  1RD7 A;  1HFR A;  3SRU X;  3S3V A;  3JWK A;  3RG9 A;  3QL3 A;  3EEJ A;  3FRA X;  2W3W A;  3JW3 A;  3FRF X;  3NZB X;  2W3A A;  3FRE X;  3QLW A;  4KD7 A;  3EEM A;  2B3Z A;  3UM8 A;  1DYH A;  3K2H A;  1DRH A;  4EIZ A;  4G95 A;  1DDS A;  2ITH A;  4KFJ A;  1J3K A;  1RB3 A;  3QLS A;  3DL5 A;  4H96 A;  3F0Q X;  4NX7 A;  4QI9 A;  4HOF A;  1DHI A;  1U70 A;  7DFR A;  3NXO A;  1YHO A;  4Q6A A;  3KFY A;  4X5H A;  3TD8 A;  1JOL A;  5HUI A;  2W9H A;  3NTZ A;  3F91 A;  5JA3 A;  3I3R A;  4QHV A;  3SRR X;  3S7A A;  1MVS A;  4LAH X;  4KJL A;  3F0B X;  3F0U X;  2W9G A;  1DYJ A;  4DDR A;  4XE6 X;  1RX4 A;  3EX8 A;  5HT4 A;  3INV A;  1RX2 A;  4P3R A;  1LY4 A;  3ZPG A;  4XT6 A;  3NZ6 X;  3E0B A;  4M7U A;  1RX6 A;  4X5F A;  4OR7 A;  1RA3 A;  1LUD A;  2L28 A;  2W9S A;  3M08 A;  2XW7 A;  4GH8 A;  1HFQ A;  3LG4 A;  4QLE A;  4G8Z X;  1J3I A;  4IXE D;  1DR4 A;  1DDR A;  1RG7 A;  4QLF A;  1RF7 A;  3FY8 X;  4QJC A;  1IA3 A;  4H95 A;  3UM5 A;  4H98 A;  3SRS X;  1DRE A;  3HJ3 A;  3DAT A;  3F8Y A;  4FGG A;  3FQC A;  4CD2 A;  3IRO A;  4ELE A;  3RO9 A;  1DR3 A;  3UM6 A;  6DFR A;  2LF1 A;  3QGT A;  3OCH A;  5ECC A;  1DIS A;  3SR5 X;  2CIG A;  5CCC A;  3NXV A;  1AOE A;  3SA2 A;  3JVX A;  1DYI A;  3K74 A;  2OBC A;  2QK8 A;  3QYL A;  1U72 A;  2P4G A;  1S3U A;  3SAI A;  3TQ8 A;  2O7P A;  1QZF A;  3CSE A;  4X5G A;  1DG7 A;  3EEK A;  4OSG A;  5ECX A;  1OHJ A;  1HFP A;  3JWF A;  3Q1H A;  2KGK A;  1AI9 A;  4XT7 A;  3JTW A;  4XRB A;  3D80 A;  3DL6 A;  4G3M A;  4ELF A;  3QLR A;  3FQO A;  1DRA A;  4HOG A;  1DHJ A;  4KJJ A;  4PSS A;  2FZI A;  2FZH A;  2OIP A;  5HQZ A;  3F0V X;  4ELH A;  4PST A;  2FZJ A;  4KEB A;  5HVB A;  3NZD A;  1PD9 A;  4LAG X;  3FQ0 A;  2G6V A;  2BLC A;  3FYV X;  1RA1 A;  4XT4 A;  3F8Z A;  4KYA A;  3IA4 A;  5DFR A;  1DLS A;  4PTJ A;  2DHF A;  5JG0 X;  5HSR A;  5HT5 A;  1E26 A;  3FS6 A;  4X5I A;  3QLZ A;  1RH3 A;  3GHC A;  3SH2 A;  1S3W A;  2H2Q A;  3IRM A;  5HSU A;  1DG5 A;  2ANQ A;  1D1G A;  1DR5 A;  3L3R A;  3JW5 A;  3JWC A;  3HBB A;  3D84 X;  3FQF A;  3SA1 A;  1DR2 A;  4DFR A;  1DIU A;  1RA8 A;  1KLK A;  4M6K A;  1RX9 A;  4KNE A;  4M2X A;  4DPD A; 
#chains in the Genus database with same CATH homology
 1RX3 A;  3NXT A;  3TQB A;  4LAE X;  1IA1 A;  5E8Q A;  3NXX A;  2W9T A;  3QFX A;  4KBN A;  1VDR A;  1PDB A;  1IA4 A;  3FYW X;  4P68 A;  4DPH A;  4EIL A;  1RB2 A;  3VCO A;  4QLG A;  5FDA A;  3NXY A;  3KJS A;  5HVE A;  4I1N A;  3FL9 A;  4HOE A;  3GHV A;  5HI6 A;  1JUV A;  3SRW X;  4EIG A;  2BLB A;  2HQP A;  3KGY A;  3CL9 A;  4KLX A;  4NX6 A;  3IA5 A;  3QLY A;  1RX5 A;  2W3V A;  2HXV A;  3CD2 A;  3CLB A;  3FQV A;  2ANO A;  1OHK A;  2W3B A;  1TDR A;  3M09 A;  5EAJ A;  4FGH A;  3DAU A;  3QL0 A;  1DLR A;  1CZ3 A;  1RX7 A;  1DR6 A;  1BOZ A;  1SEJ A;  2JYB A;  1RA2 A;  4PSY A;  4HA9 A;  4TU5 X;  1DRB A;  1RC4 A;  1DHF A;  1RX8 A;  1IA2 A;  5HF0 X;  4XEC X;  2C2T A;  4KM0 A;  5U27 A;  3JSU A;  3NZA X;  1RX1 A;  4H97 A;  4IXG X;  4QJZ D;  4KY8 A;  8DFR A;  3IRN A;  1VJ3 A;  4ECK A;  1LY3 A;  4LEK X;  4EJ1 A;  2CD2 A;  1M7A A;  1CD2 A;  4KL9 A;  4I13 A;  4ELB A;  1RE7 A;  1RA9 A;  3GHW A;  1DR7 A;  2AZN A;  3EEL A;  2BLA A;  3R33 A;  3S9U A;  3KJR A;  5HPB A;  3K45 A;  1DF7 A;  2ZZA A;  3K47 A;  4RGC A;  4IXF X;  4KAK A;  1DYR A;  5HQY A;  2INQ A;  2BL9 A;  3QLX A;  1DAJ A;  3DG8 A;  3FRD X;  2DRC A;  1KMV A;  2D0K A;  4Q0E A;  4KJK A;  1MVT A;  4P3Q A;  1BZF A;  2C2S A;  1DRF A;  3N0H A;  3FY9 X;  3SQY X;  3DRC A;  3NZC X;  5HF2 X;  5CC9 A;  3TQA A;  1ZDR A;  3F0S X;  3NU0 A;  3F0X X;  2D5N A;  1PD8 A;  4XT8 A;  1JOM A;  1KMS A;  1AO8 A;  4HA7 A;  4PDJ A;  3FRB X;  4XT5 A;  1U71 A;  5U26 A;  1M78 A;  3TQ9 A;  1DG8 A;  1S3Y A;  3IX9 A;  4X5J A;  1S3V A;  4M7V A;  4KY4 A;  4Q0D A;  4Q67 A;  4DP3 A;  4ELG A;  3DGA A;  4M6J A;  3GI2 A;  4FHB A;  2HM9 A;  3NRR A;  3FL8 A;  3QG2 A;  3GYF A;  4M6L A;  3NZ9 X;  3ROA A;  3JWM A;  3I8A X;  3SGY A;  3SRQ X;  3ZPC A;  3DFR A;  2GD9 A;  5DXV A;  3EIG A;  1J3J A;  4KM2 A;  2W3M A;  4P66 A;  1M79 A;  1DR1 A;  4PTH A;  3NXR A;  3KY8 A;  3QYO A;  3OAF A;  3FQZ A;  1RD7 A;  1HFR A;  3SRU X;  3S3V A;  3JWK A;  3RG9 A;  3QL3 A;  3EEJ A;  3FRA X;  2W3W A;  3JW3 A;  3FRF X;  3NZB X;  2W3A A;  3FRE X;  3QLW A;  4KD7 A;  3EEM A;  2B3Z A;  3UM8 A;  1DYH A;  3K2H A;  1DRH A;  4EIZ A;  4G95 A;  1DDS A;  2ITH A;  4KFJ A;  1J3K A;  1RB3 A;  3QLS A;  3DL5 A;  4H96 A;  3F0Q X;  4NX7 A;  4QI9 A;  4HOF A;  1DHI A;  1U70 A;  7DFR A;  3NXO A;  1YHO A;  4Q6A A;  3KFY A;  4X5H A;  3TD8 A;  1JOL A;  5HUI A;  2W9H A;  3NTZ A;  3F91 A;  5JA3 A;  3I3R A;  4QHV A;  3SRR X;  3S7A A;  1MVS A;  4LAH X;  4KJL A;  3F0B X;  3F0U X;  2W9G A;  1DYJ A;  4DDR A;  4XE6 X;  1RX4 A;  3EX8 A;  5HT4 A;  3INV A;  1RX2 A;  4P3R A;  1LY4 A;  3ZPG A;  4XT6 A;  3NZ6 X;  3E0B A;  4M7U A;  1RX6 A;  4X5F A;  4OR7 A;  1RA3 A;  1LUD A;  2L28 A;  2W9S A;  3M08 A;  2XW7 A;  4GH8 A;  1HFQ A;  3LG4 A;  4QLE A;  4G8Z X;  1J3I A;  4IXE D;  1DR4 A;  1DDR A;  1RG7 A;  4QLF A;  1RF7 A;  3FY8 X;  4QJC A;  1IA3 A;  4H95 A;  3UM5 A;  4H98 A;  3SRS X;  1DRE A;  3HJ3 A;  3DAT A;  3F8Y A;  4FGG A;  3FQC A;  4CD2 A;  3IRO A;  4ELE A;  3RO9 A;  1DR3 A;  3UM6 A;  6DFR A;  2LF1 A;  3QGT A;  3OCH A;  5ECC A;  1DIS A;  3SR5 X;  2CIG A;  5CCC A;  3NXV A;  1AOE A;  3SA2 A;  3JVX A;  1DYI A;  3K74 A;  2OBC A;  2QK8 A;  3QYL A;  1U72 A;  2P4G A;  1S3U A;  3SAI A;  3TQ8 A;  2O7P A;  1QZF A;  3CSE A;  4X5G A;  1DG7 A;  3EEK A;  4OSG A;  5ECX A;  1OHJ A;  1HFP A;  3JWF A;  3Q1H A;  2KGK A;  1AI9 A;  4XT7 A;  3JTW A;  4XRB A;  3D80 A;  3DL6 A;  4G3M A;  4ELF A;  3QLR A;  3FQO A;  1DRA A;  4HOG A;  1DHJ A;  4KJJ A;  4PSS A;  2FZI A;  2FZH A;  2OIP A;  5HQZ A;  3F0V X;  4ELH A;  4PST A;  2FZJ A;  4KEB A;  5HVB A;  3NZD A;  1PD9 A;  4LAG X;  3FQ0 A;  2G6V A;  2BLC A;  3FYV X;  1RA1 A;  4XT4 A;  3F8Z A;  4KYA A;  3IA4 A;  5DFR A;  1DLS A;  4PTJ A;  2DHF A;  5JG0 X;  5HSR A;  5HT5 A;  1E26 A;  3FS6 A;  4X5I A;  3QLZ A;  1RH3 A;  3GHC A;  3SH2 A;  1S3W A;  2H2Q A;  3IRM A;  5HSU A;  1DG5 A;  2ANQ A;  1D1G A;  1DR5 A;  3L3R A;  3JW5 A;  3JWC A;  3HBB A;  3D84 X;  3FQF A;  3SA1 A;  1DR2 A;  4DFR A;  1DIU A;  1RA8 A;  1KLK A;  4M6K A;  1RX9 A;  4KNE A;  4M2X A;  4DPD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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