3GHCA

Design, synthesis, and x-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agenst
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFSRMTTTSSVEGKQNLVIMGKKTWFSIPEKSRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents
pubmed doi rcsb
molecule keywords Dihydrofolate reductase
molecule tags Oxidoreductase
source organism Homo sapiens
total genus 55
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3ghcA00
2C2TA 1U71A 4CD2A 4ECKA 5DFRA 1DYHA 4QLEA 1YHOA 3TQBA 1RX2A 3JVXA 1DISA 3F0QX 3L3RA 3DATA 1PD8A 3S3VA 1IA2A 1TDRA 1DG5A 3FL9A 4X5GA 3NU0A 3TQ9A 3ROAA 4KAKA 3D80A 3QLRA 3DL5A 1DREA 3QLZA 3FY9X 1RX1A 5HPBA 3SGYA 1RA2A 4TU5X 3QGTA 3S9UA 1DDSA 2FZIA 3VCOA 1S3WA 3FYVX 4PTHA 1S3YA 1S3VA 2W9TA 2QK8A 4KEBA 5DXVA 1DYJA 1BZFA 2W9HA 1E26A 5HF2X 3NZAX 4QJCA 3JWFA 3Q1HA 3CLBA 2BLAA 3CL9A 1DRBA 4XE6X 4H98A 3F8YA 4LAGX 2BL9A 3FYWX 3GYFA 3RO9A 3F0VX 1OHJA 2JYBA 1PD9A 4KD7A 3ZPCA 2CD2A 2FZHA 3NZ9X 1MVTA 2HXVA 3QL3A 2ITHA 4XT6A 1DR7A 4H95A 3QL0A 1DLRA 4FHBA 4P66A 3UM6A 3DFRA 3K2HA 2HM9A 3GHVA 1RH3A 1BOZA 3SA2A 3FRDX 2ANOA 4PSSA 3ZPGA 3FRFX 4QI9A 1RX5A 5JG0X 1RX7A 3GHCA 3SR5X 2W3MA 3I3RA 3QG2A 4G95A 3SRRX 1DIUA 3N0HA 4EIZA 4FGGA 3KJSA 1DRAA 4XECX 3SAIA 1RD7A 3FRBX 1DRFA 3R33A 3S7AA 3SRWX 4X5FA 4ELEA 3QLXA 5HT5A 4GH8A 3GHWA 3EEKA 1RA8A 3JWMA 2HQPA 2LF1A 5HQYA 1AI9A 1JOMA 4H96A 4XT7A 4Q0DA 1M78A 1KMSA 1DHFA 3NXOA 4M2XA 4I13A 3FRAX 2DHFA 2W9GA 3JWCA 3KGYA 1SEJA 3TQ8A 2W3AA 4M6JA 4DP3A 3KFYA 3HJ3A 3NXYA 3F91A 1S3UA 4DPHA 1DR5A 4KLXA 4EJ1A 4Q67A 4G3MA 4HOEA 5HSUA 4ELGA 3KJRA 3F8ZA 3SRSX 1J3IA 1RG7A 2FZJA 1IA4A 4PTJA 3DG8A 4RGCA 4EIGA 1KLKA 4PDJA 3KY8A 7DFRA 2P4GA 1HFRA 5HT4A 4KJLA 3E0BA 1DF7A 5U26A 1RE7A 3F0UX 4ELFA 3NZ6X 1RX8A 1DG8A 1DHIA 3FQFA 2W3BA 3UM5A 3K47A 1RA9A 4XT4A 5HI6A 1AO8A 5CC9A 3IRMA 4QHVA 1OHKA 1RC4A 2H2QA 3SQYX 3LG4A 3CD2A 2ANQA 2OBCA 1DR1A 1DRHA 3NXVA 2W3VA 1DR6A 3SA1A 3DRCA 1RB3A 3FQCA 4KY8A 3OAFA 3EELA 4X5IA 3DAUA 4DPDA 2DRCA 1RX6A 1J3KA 1DAJA 1PDBA 3IA5A 3K45A 5E8QA 1HFQA 3FL8A 5HQZA 1DR3A 3OCHA 3F0XX 5HVBA 4KJJA 4NX6A 1ZDRA 5HVEA 1MVSA 3QYOA 4QLFA 3NXRA 3UM8A 3NXXA 4XT8A 1J3JA 4XT5A 1HFPA 3NZCX 3FQVA 4IXED 4KM0A 3FQ0A 3JW3A 3QLSA 4LEKX 4P3RA 3QFXA 1D1GA 1LY3A 2W9SA 1DLSA 1IA1A 4KNEA 2XW7A 2W3WA 3QLWA 4OR7A 4KY4A 3JW5A 3F0SX 4PSTA 4ELHA 4Q0EA 4X5HA 2KGKA 2CIGA 3EX8A 3FQZA 3DGAA 3IX9A 3IA4A 3EEJA 5HSRA 3EIGA 1QZFA 2L28A 6DFRA 1RX3A 3F0BX 4KM2A 1IA3A 4KL9A 4M7UA 1DR4A 1RX4A 3EEMA 3TD8A 4P3QA 3TQAA 4PSYA 5CCCA 3FREX 3NZBX 1DDRA 4LAHX 1M7AA 4P68A 3M08A 1LY4A 4NX7A 1DHJA 2INQA 1M79A 1CZ3A 2OIPA 3SRUX 3INVA 4Q6AA 4XRBA 1CD2A 3SRQX 1JOLA 4ELBA 3QLYA 3M09A 4M6LA 4H97A 3SH2A 3FS6A 2AZNA 2B3ZA 4FGHA 2ZZAA 1VDRA 4DDRA 5EAJA 3JWKA 3FY8X 2BLBA 3K74A 3RG9A 4IXFX 1DYRA 1JUVA 5U27A 5JA3A 4QJZD 5HUIA 1U72A 3NXTA 1RF7A 1LUDA 4DFRA 4EILA 4HA7A 3D84X 3GI2A 2D0KA 4HOGA 1RB2A 3FQOA 1AOEA 2BLCA 3IROA 3CSEA 3I8AX 4HA9A 3DL6A 4G8ZX 2G6VA 4KBNA 4KYAA 3NRRA 5HF0X 3NTZA 1DYIA 4M6KA 4QLGA 5FDAA 4KJKA 4X5JA 2O7PA 4HOFA 1RA3A 1DR2A 4LAEX 1RX9A 1U70A 1DG7A 3HBBA 5ECXA 3IRNA 4IXGX 2C2SA 3QYLA 1RA1A 4I1NA 5ECCA 3NZDA 3JTWA 4OSGA 8DFRA 1VJ3A 1KMVA 2D5NA 4M7VA 4KFJA 3JSUA 2GD9A
chains in the Genus database with same CATH superfamily
2C2TA 1U71A 4CD2A 4ECKA 5DFRA 1DYHA 4QLEA 1YHOA 3TQBA 1RX2A 3JVXA 1DISA 3F0QX 3L3RA 3DATA 1PD8A 3S3VA 1IA2A 1TDRA 1DG5A 3FL9A 4X5GA 3NU0A 3TQ9A 3ROAA 4KAKA 3D80A 3QLRA 3DL5A 1DREA 3QLZA 3FY9X 1RX1A 5HPBA 3SGYA 1RA2A 4TU5X 3QGTA 3S9UA 1DDSA 2FZIA 3VCOA 1S3WA 3FYVX 4PTHA 1S3YA 1S3VA 2W9TA 2QK8A 4KEBA 5DXVA 1DYJA 1BZFA 2W9HA 1E26A 5HF2X 3NZAX 4QJCA 3JWFA 3Q1HA 3CLBA 2BLAA 3CL9A 1DRBA 4XE6X 4H98A 3F8YA 4LAGX 2BL9A 3FYWX 3GYFA 3RO9A 3F0VX 1OHJA 2JYBA 1PD9A 4KD7A 3ZPCA 2CD2A 2FZHA 3NZ9X 1MVTA 2HXVA 3QL3A 2ITHA 4XT6A 1DR7A 4H95A 3QL0A 1DLRA 4FHBA 4P66A 3UM6A 3DFRA 3K2HA 2HM9A 3GHVA 1RH3A 1BOZA 3SA2A 3FRDX 2ANOA 4PSSA 3ZPGA 3FRFX 4QI9A 1RX5A 5JG0X 1RX7A 3GHCA 3SR5X 2W3MA 3I3RA 3QG2A 4G95A 3SRRX 1DIUA 3N0HA 4EIZA 4FGGA 3KJSA 1DRAA 4XECX 3SAIA 1RD7A 3FRBX 1DRFA 3R33A 3S7AA 3SRWX 4X5FA 4ELEA 3QLXA 5HT5A 4GH8A 3GHWA 3EEKA 1RA8A 3JWMA 2HQPA 2LF1A 5HQYA 1AI9A 1JOMA 4H96A 4XT7A 4Q0DA 1M78A 1KMSA 1DHFA 3NXOA 4M2XA 4I13A 3FRAX 2DHFA 2W9GA 3JWCA 3KGYA 1SEJA 3TQ8A 2W3AA 4M6JA 4DP3A 3KFYA 3HJ3A 3NXYA 3F91A 1S3UA 4DPHA 1DR5A 4KLXA 4EJ1A 4Q67A 4G3MA 4HOEA 5HSUA 4ELGA 3KJRA 3F8ZA 3SRSX 1J3IA 1RG7A 2FZJA 1IA4A 4PTJA 3DG8A 4RGCA 4EIGA 1KLKA 4PDJA 3KY8A 7DFRA 2P4GA 1HFRA 5HT4A 4KJLA 3E0BA 1DF7A 5U26A 1RE7A 3F0UX 4ELFA 3NZ6X 1RX8A 1DG8A 1DHIA 3FQFA 2W3BA 3UM5A 3K47A 1RA9A 4XT4A 5HI6A 1AO8A 5CC9A 3IRMA 4QHVA 1OHKA 1RC4A 2H2QA 3SQYX 3LG4A 3CD2A 2ANQA 2OBCA 1DR1A 1DRHA 3NXVA 2W3VA 1DR6A 3SA1A 3DRCA 1RB3A 3FQCA 4KY8A 3OAFA 3EELA 4X5IA 3DAUA 4DPDA 2DRCA 1RX6A 1J3KA 1DAJA 1PDBA 3IA5A 3K45A 5E8QA 1HFQA 3FL8A 5HQZA 1DR3A 3OCHA 3F0XX 5HVBA 4KJJA 4NX6A 1ZDRA 5HVEA 1MVSA 3QYOA 4QLFA 3NXRA 3UM8A 3NXXA 4XT8A 1J3JA 4XT5A 1HFPA 3NZCX 3FQVA 4IXED 4KM0A 3FQ0A 3JW3A 3QLSA 4LEKX 4P3RA 3QFXA 1D1GA 1LY3A 2W9SA 1DLSA 1IA1A 4KNEA 2XW7A 2W3WA 3QLWA 4OR7A 4KY4A 3JW5A 3F0SX 4PSTA 4ELHA 4Q0EA 4X5HA 2KGKA 2CIGA 3EX8A 3FQZA 3DGAA 3IX9A 3IA4A 3EEJA 5HSRA 3EIGA 1QZFA 2L28A 6DFRA 1RX3A 3F0BX 4KM2A 1IA3A 4KL9A 4M7UA 1DR4A 1RX4A 3EEMA 3TD8A 4P3QA 3TQAA 4PSYA 5CCCA 3FREX 3NZBX 1DDRA 4LAHX 1M7AA 4P68A 3M08A 1LY4A 4NX7A 1DHJA 2INQA 1M79A 1CZ3A 2OIPA 3SRUX 3INVA 4Q6AA 4XRBA 1CD2A 3SRQX 1JOLA 4ELBA 3QLYA 3M09A 4M6LA 4H97A 3SH2A 3FS6A 2AZNA 2B3ZA 4FGHA 2ZZAA 1VDRA 4DDRA 5EAJA 3JWKA 3FY8X 2BLBA 3K74A 3RG9A 4IXFX 1DYRA 1JUVA 5U27A 5JA3A 4QJZD 5HUIA 1U72A 3NXTA 1RF7A 1LUDA 4DFRA 4EILA 4HA7A 3D84X 3GI2A 2D0KA 4HOGA 1RB2A 3FQOA 1AOEA 2BLCA 3IROA 3CSEA 3I8AX 4HA9A 3DL6A 4G8ZX 2G6VA 4KBNA 4KYAA 3NRRA 5HF0X 3NTZA 1DYIA 4M6KA 4QLGA 5FDAA 4KJKA 4X5JA 2O7PA 4HOFA 1RA3A 1DR2A 4LAEX 1RX9A 1U70A 1DG7A 3HBBA 5ECXA 3IRNA 4IXGX 2C2SA 3QYLA 1RA1A 4I1NA 5ECCA 3NZDA 3JTWA 4OSGA 8DFRA 1VJ3A 1KMVA 2D5NA 4M7VA 4KFJA 3JSUA 2GD9A
chains in the Genus database with same CATH topology
2C2TA 1U71A 4CD2A 4ECKA 5DFRA 1DYHA 4QLEA 1YHOA 3TQBA 1RX2A 3JVXA 1DISA 3F0QX 3L3RA 3DATA 1PD8A 3S3VA 1IA2A 1TDRA 1DG5A 3FL9A 4X5GA 3NU0A 3TQ9A 3ROAA 4KAKA 3D80A 3QLRA 3DL5A 1DREA 3QLZA 3FY9X 1RX1A 5HPBA 3SGYA 1RA2A 4TU5X 3QGTA 3S9UA 1DDSA 2FZIA 3VCOA 1S3WA 3FYVX 4PTHA 1S3YA 1S3VA 2W9TA 2QK8A 4KEBA 5DXVA 1DYJA 1BZFA 2W9HA 1E26A 5HF2X 3NZAX 4QJCA 3JWFA 3Q1HA 3CLBA 2BLAA 3CL9A 1DRBA 4XE6X 4H98A 3F8YA 4LAGX 2BL9A 3FYWX 3GYFA 3RO9A 3F0VX 1OHJA 2JYBA 1PD9A 4KD7A 3ZPCA 2CD2A 2FZHA 3NZ9X 1MVTA 2HXVA 3QL3A 2ITHA 4XT6A 1DR7A 4H95A 3QL0A 1DLRA 4FHBA 4P66A 3UM6A 3DFRA 3K2HA 2HM9A 3GHVA 1RH3A 1BOZA 3SA2A 3FRDX 2ANOA 4PSSA 3ZPGA 3FRFX 4QI9A 1RX5A 5JG0X 1RX7A 3GHCA 3SR5X 2W3MA 3I3RA 3QG2A 4G95A 3SRRX 1DIUA 3N0HA 4EIZA 4FGGA 3KJSA 1DRAA 4XECX 3SAIA 1RD7A 3FRBX 1DRFA 3R33A 3S7AA 3SRWX 4X5FA 4ELEA 3QLXA 5HT5A 4GH8A 3GHWA 3EEKA 1RA8A 3JWMA 2HQPA 2LF1A 5HQYA 1AI9A 1JOMA 4H96A 4XT7A 4Q0DA 1M78A 1KMSA 1DHFA 3NXOA 4M2XA 4I13A 3FRAX 2DHFA 2W9GA 3JWCA 3KGYA 1SEJA 3TQ8A 2W3AA 4M6JA 4DP3A 3KFYA 3HJ3A 3NXYA 3F91A 1S3UA 4DPHA 1DR5A 4KLXA 4EJ1A 4Q67A 4G3MA 4HOEA 5HSUA 4ELGA 3KJRA 3F8ZA 3SRSX 1J3IA 1RG7A 2FZJA 1IA4A 4PTJA 3DG8A 4RGCA 4EIGA 1KLKA 4PDJA 3KY8A 7DFRA 2P4GA 1HFRA 5HT4A 4KJLA 3E0BA 1DF7A 5U26A 1RE7A 3F0UX 4ELFA 3NZ6X 1RX8A 1DG8A 1DHIA 3FQFA 2W3BA 3UM5A 3K47A 1RA9A 4XT4A 5HI6A 1AO8A 5CC9A 3IRMA 4QHVA 1OHKA 1RC4A 2H2QA 3SQYX 3LG4A 3CD2A 2ANQA 2OBCA 1DR1A 1DRHA 3NXVA 2W3VA 1DR6A 3SA1A 3DRCA 1RB3A 3FQCA 4KY8A 3OAFA 3EELA 4X5IA 3DAUA 4DPDA 2DRCA 1RX6A 1J3KA 1DAJA 1PDBA 3IA5A 3K45A 5E8QA 1HFQA 3FL8A 5HQZA 1DR3A 3OCHA 3F0XX 5HVBA 4KJJA 4NX6A 1ZDRA 5HVEA 1MVSA 3QYOA 4QLFA 3NXRA 3UM8A 3NXXA 4XT8A 1J3JA 4XT5A 1HFPA 3NZCX 3FQVA 4IXED 4KM0A 3FQ0A 3JW3A 3QLSA 4LEKX 4P3RA 3QFXA 1D1GA 1LY3A 2W9SA 1DLSA 1IA1A 4KNEA 2XW7A 2W3WA 3QLWA 4OR7A 4KY4A 3JW5A 3F0SX 4PSTA 4ELHA 4Q0EA 4X5HA 2KGKA 2CIGA 3EX8A 3FQZA 3DGAA 3IX9A 3IA4A 3EEJA 5HSRA 3EIGA 1QZFA 2L28A 6DFRA 1RX3A 3F0BX 4KM2A 1IA3A 4KL9A 4M7UA 1DR4A 1RX4A 3EEMA 3TD8A 4P3QA 3TQAA 4PSYA 5CCCA 3FREX 3NZBX 1DDRA 4LAHX 1M7AA 4P68A 3M08A 1LY4A 4NX7A 1DHJA 2INQA 1M79A 1CZ3A 2OIPA 3SRUX 3INVA 4Q6AA 4XRBA 1CD2A 3SRQX 1JOLA 4ELBA 3QLYA 3M09A 4M6LA 4H97A 3SH2A 3FS6A 2AZNA 2B3ZA 4FGHA 2ZZAA 1VDRA 4DDRA 5EAJA 3JWKA 3FY8X 2BLBA 3K74A 3RG9A 4IXFX 1DYRA 1JUVA 5U27A 5JA3A 4QJZD 5HUIA 1U72A 3NXTA 1RF7A 1LUDA 4DFRA 4EILA 4HA7A 3D84X 3GI2A 2D0KA 4HOGA 1RB2A 3FQOA 1AOEA 2BLCA 3IROA 3CSEA 3I8AX 4HA9A 3DL6A 4G8ZX 2G6VA 4KBNA 4KYAA 3NRRA 5HF0X 3NTZA 1DYIA 4M6KA 4QLGA 5FDAA 4KJKA 4X5JA 2O7PA 4HOFA 1RA3A 1DR2A 4LAEX 1RX9A 1U70A 1DG7A 3HBBA 5ECXA 3IRNA 4IXGX 2C2SA 3QYLA 1RA1A 4I1NA 5ECCA 3NZDA 3JTWA 4OSGA 8DFRA 1VJ3A 1KMVA 2D5NA 4M7VA 4KFJA 3JSUA 2GD9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C2T A;  1U71 A;  4CD2 A;  4ECK A;  5DFR A;  1DYH A;  4QLE A;  1YHO A;  3TQB A;  1RX2 A;  3JVX A;  1DIS A;  3F0Q X;  3L3R A;  3DAT A;  1PD8 A;  3S3V A;  1IA2 A;  1TDR A;  1DG5 A;  3FL9 A;  4X5G A;  3NU0 A;  3TQ9 A;  3ROA A;  4KAK A;  3D80 A;  3QLR A;  3DL5 A;  1DRE A;  3QLZ A;  3FY9 X;  1RX1 A;  5HPB A;  3SGY A;  1RA2 A;  4TU5 X;  3QGT A;  3S9U A;  1DDS A;  2FZI A;  3VCO A;  1S3W A;  3FYV X;  4PTH A;  1S3Y A;  1S3V A;  2W9T A;  2QK8 A;  4KEB A;  5DXV A;  1DYJ A;  1BZF A;  2W9H A;  1E26 A;  5HF2 X;  3NZA X;  4QJC A;  3JWF A;  3Q1H A;  3CLB A;  2BLA A;  3CL9 A;  1DRB A;  4XE6 X;  4H98 A;  3F8Y A;  4LAG X;  2BL9 A;  3FYW X;  3GYF A;  3RO9 A;  3F0V X;  1OHJ A;  2JYB A;  1PD9 A;  4KD7 A;  3ZPC A;  2CD2 A;  2FZH A;  3NZ9 X;  1MVT A;  2HXV A;  3QL3 A;  2ITH A;  4XT6 A;  1DR7 A;  4H95 A;  3QL0 A;  1DLR A;  4FHB A;  4P66 A;  3UM6 A;  3DFR A;  3K2H A;  2HM9 A;  3GHV A;  1RH3 A;  1BOZ A;  3SA2 A;  3FRD X;  2ANO A;  4PSS A;  3ZPG A;  3FRF X;  4QI9 A;  1RX5 A;  5JG0 X;  1RX7 A;  3GHC A;  3SR5 X;  2W3M A;  3I3R A;  3QG2 A;  4G95 A;  3SRR X;  1DIU A;  3N0H A;  4EIZ A;  4FGG A;  3KJS A;  1DRA A;  4XEC X;  3SAI A;  1RD7 A;  3FRB X;  1DRF A;  3R33 A;  3S7A A;  3SRW X;  4X5F A;  4ELE A;  3QLX A;  5HT5 A;  4GH8 A;  3GHW A;  3EEK A;  1RA8 A;  3JWM A;  2HQP A;  2LF1 A;  5HQY A;  1AI9 A;  1JOM A;  4H96 A;  4XT7 A;  4Q0D A;  1M78 A;  1KMS A;  1DHF A;  3NXO A;  4M2X A;  4I13 A;  3FRA X;  2DHF A;  2W9G A;  3JWC A;  3KGY A;  1SEJ A;  3TQ8 A;  2W3A A;  4M6J A;  4DP3 A;  3KFY A;  3HJ3 A;  3NXY A;  3F91 A;  1S3U A;  4DPH A;  1DR5 A;  4KLX A;  4EJ1 A;  4Q67 A;  4G3M A;  4HOE A;  5HSU A;  4ELG A;  3KJR A;  3F8Z A;  3SRS X;  1J3I A;  1RG7 A;  2FZJ A;  1IA4 A;  4PTJ A;  3DG8 A;  4RGC A;  4EIG A;  1KLK A;  4PDJ A;  3KY8 A;  7DFR A;  2P4G A;  1HFR A;  5HT4 A;  4KJL A;  3E0B A;  1DF7 A;  5U26 A;  1RE7 A;  3F0U X;  4ELF A;  3NZ6 X;  1RX8 A;  1DG8 A;  1DHI A;  3FQF A;  2W3B A;  3UM5 A;  3K47 A;  1RA9 A;  4XT4 A;  5HI6 A;  1AO8 A;  5CC9 A;  3IRM A;  4QHV A;  1OHK A;  1RC4 A;  2H2Q A;  3SQY X;  3LG4 A;  3CD2 A;  2ANQ A;  2OBC A;  1DR1 A;  1DRH A;  3NXV A;  2W3V A;  1DR6 A;  3SA1 A;  3DRC A;  1RB3 A;  3FQC A;  4KY8 A;  3OAF A;  3EEL A;  4X5I A;  3DAU A;  4DPD A;  2DRC A;  1RX6 A;  1J3K A;  1DAJ A;  1PDB A;  3IA5 A;  3K45 A;  5E8Q A;  1HFQ A;  3FL8 A;  5HQZ A;  1DR3 A;  3OCH A;  3F0X X;  5HVB A;  4KJJ A;  4NX6 A;  1ZDR A;  5HVE A;  1MVS A;  3QYO A;  4QLF A;  3NXR A;  3UM8 A;  3NXX A;  4XT8 A;  1J3J A;  4XT5 A;  1HFP A;  3NZC X;  3FQV A;  4IXE D;  4KM0 A;  3FQ0 A;  3JW3 A;  3QLS A;  4LEK X;  4P3R A;  3QFX A;  1D1G A;  1LY3 A;  2W9S A;  1DLS A;  1IA1 A;  4KNE A;  2XW7 A;  2W3W A;  3QLW A;  4OR7 A;  4KY4 A;  3JW5 A;  3F0S X;  4PST A;  4ELH A;  4Q0E A;  4X5H A;  2KGK A;  2CIG A;  3EX8 A;  3FQZ A;  3DGA A;  3IX9 A;  3IA4 A;  3EEJ A;  5HSR A;  3EIG A;  1QZF A;  2L28 A;  6DFR A;  1RX3 A;  3F0B X;  4KM2 A;  1IA3 A;  4KL9 A;  4M7U A;  1DR4 A;  1RX4 A;  3EEM A;  3TD8 A;  4P3Q A;  3TQA A;  4PSY A;  5CCC A;  3FRE X;  3NZB X;  1DDR A;  4LAH X;  1M7A A;  4P68 A;  3M08 A;  1LY4 A;  4NX7 A;  1DHJ A;  2INQ A;  1M79 A;  1CZ3 A;  2OIP A;  3SRU X;  3INV A;  4Q6A A;  4XRB A;  1CD2 A;  3SRQ X;  1JOL A;  4ELB A;  3QLY A;  3M09 A;  4M6L A;  4H97 A;  3SH2 A;  3FS6 A;  2AZN A;  2B3Z A;  4FGH A;  2ZZA A;  1VDR A;  4DDR A;  5EAJ A;  3JWK A;  3FY8 X;  2BLB A;  3K74 A;  3RG9 A;  4IXF X;  1DYR A;  1JUV A;  5U27 A;  5JA3 A;  4QJZ D;  5HUI A;  1U72 A;  3NXT A;  1RF7 A;  1LUD A;  4DFR A;  4EIL A;  4HA7 A;  3D84 X;  3GI2 A;  2D0K A;  4HOG A;  1RB2 A;  3FQO A;  1AOE A;  2BLC A;  3IRO A;  3CSE A;  3I8A X;  4HA9 A;  3DL6 A;  4G8Z X;  2G6V A;  4KBN A;  4KYA A;  3NRR A;  5HF0 X;  3NTZ A;  1DYI A;  4M6K A;  4QLG A;  5FDA A;  4KJK A;  4X5J A;  2O7P A;  4HOF A;  1RA3 A;  1DR2 A;  4LAE X;  1RX9 A;  1U70 A;  1DG7 A;  3HBB A;  5ECX A;  3IRN A;  4IXG X;  2C2S A;  3QYL A;  1RA1 A;  4I1N A;  5ECC A;  3NZD A;  3JTW A;  4OSG A;  8DFR A;  1VJ3 A;  1KMV A;  2D5N A;  4M7V A;  4KFJ A;  3JSU A;  2GD9 A; 
#chains in the Genus database with same CATH topology
 2C2T A;  1U71 A;  4CD2 A;  4ECK A;  5DFR A;  1DYH A;  4QLE A;  1YHO A;  3TQB A;  1RX2 A;  3JVX A;  1DIS A;  3F0Q X;  3L3R A;  3DAT A;  1PD8 A;  3S3V A;  1IA2 A;  1TDR A;  1DG5 A;  3FL9 A;  4X5G A;  3NU0 A;  3TQ9 A;  3ROA A;  4KAK A;  3D80 A;  3QLR A;  3DL5 A;  1DRE A;  3QLZ A;  3FY9 X;  1RX1 A;  5HPB A;  3SGY A;  1RA2 A;  4TU5 X;  3QGT A;  3S9U A;  1DDS A;  2FZI A;  3VCO A;  1S3W A;  3FYV X;  4PTH A;  1S3Y A;  1S3V A;  2W9T A;  2QK8 A;  4KEB A;  5DXV A;  1DYJ A;  1BZF A;  2W9H A;  1E26 A;  5HF2 X;  3NZA X;  4QJC A;  3JWF A;  3Q1H A;  3CLB A;  2BLA A;  3CL9 A;  1DRB A;  4XE6 X;  4H98 A;  3F8Y A;  4LAG X;  2BL9 A;  3FYW X;  3GYF A;  3RO9 A;  3F0V X;  1OHJ A;  2JYB A;  1PD9 A;  4KD7 A;  3ZPC A;  2CD2 A;  2FZH A;  3NZ9 X;  1MVT A;  2HXV A;  3QL3 A;  2ITH A;  4XT6 A;  1DR7 A;  4H95 A;  3QL0 A;  1DLR A;  4FHB A;  4P66 A;  3UM6 A;  3DFR A;  3K2H A;  2HM9 A;  3GHV A;  1RH3 A;  1BOZ A;  3SA2 A;  3FRD X;  2ANO A;  4PSS A;  3ZPG A;  3FRF X;  4QI9 A;  1RX5 A;  5JG0 X;  1RX7 A;  3GHC A;  3SR5 X;  2W3M A;  3I3R A;  3QG2 A;  4G95 A;  3SRR X;  1DIU A;  3N0H A;  4EIZ A;  4FGG A;  3KJS A;  1DRA A;  4XEC X;  3SAI A;  1RD7 A;  3FRB X;  1DRF A;  3R33 A;  3S7A A;  3SRW X;  4X5F A;  4ELE A;  3QLX A;  5HT5 A;  4GH8 A;  3GHW A;  3EEK A;  1RA8 A;  3JWM A;  2HQP A;  2LF1 A;  5HQY A;  1AI9 A;  1JOM A;  4H96 A;  4XT7 A;  4Q0D A;  1M78 A;  1KMS A;  1DHF A;  3NXO A;  4M2X A;  4I13 A;  3FRA X;  2DHF A;  2W9G A;  3JWC A;  3KGY A;  1SEJ A;  3TQ8 A;  2W3A A;  4M6J A;  4DP3 A;  3KFY A;  3HJ3 A;  3NXY A;  3F91 A;  1S3U A;  4DPH A;  1DR5 A;  4KLX A;  4EJ1 A;  4Q67 A;  4G3M A;  4HOE A;  5HSU A;  4ELG A;  3KJR A;  3F8Z A;  3SRS X;  1J3I A;  1RG7 A;  2FZJ A;  1IA4 A;  4PTJ A;  3DG8 A;  4RGC A;  4EIG A;  1KLK A;  4PDJ A;  3KY8 A;  7DFR A;  2P4G A;  1HFR A;  5HT4 A;  4KJL A;  3E0B A;  1DF7 A;  5U26 A;  1RE7 A;  3F0U X;  4ELF A;  3NZ6 X;  1RX8 A;  1DG8 A;  1DHI A;  3FQF A;  2W3B A;  3UM5 A;  3K47 A;  1RA9 A;  4XT4 A;  5HI6 A;  1AO8 A;  5CC9 A;  3IRM A;  4QHV A;  1OHK A;  1RC4 A;  2H2Q A;  3SQY X;  3LG4 A;  3CD2 A;  2ANQ A;  2OBC A;  1DR1 A;  1DRH A;  3NXV A;  2W3V A;  1DR6 A;  3SA1 A;  3DRC A;  1RB3 A;  3FQC A;  4KY8 A;  3OAF A;  3EEL A;  4X5I A;  3DAU A;  4DPD A;  2DRC A;  1RX6 A;  1J3K A;  1DAJ A;  1PDB A;  3IA5 A;  3K45 A;  5E8Q A;  1HFQ A;  3FL8 A;  5HQZ A;  1DR3 A;  3OCH A;  3F0X X;  5HVB A;  4KJJ A;  4NX6 A;  1ZDR A;  5HVE A;  1MVS A;  3QYO A;  4QLF A;  3NXR A;  3UM8 A;  3NXX A;  4XT8 A;  1J3J A;  4XT5 A;  1HFP A;  3NZC X;  3FQV A;  4IXE D;  4KM0 A;  3FQ0 A;  3JW3 A;  3QLS A;  4LEK X;  4P3R A;  3QFX A;  1D1G A;  1LY3 A;  2W9S A;  1DLS A;  1IA1 A;  4KNE A;  2XW7 A;  2W3W A;  3QLW A;  4OR7 A;  4KY4 A;  3JW5 A;  3F0S X;  4PST A;  4ELH A;  4Q0E A;  4X5H A;  2KGK A;  2CIG A;  3EX8 A;  3FQZ A;  3DGA A;  3IX9 A;  3IA4 A;  3EEJ A;  5HSR A;  3EIG A;  1QZF A;  2L28 A;  6DFR A;  1RX3 A;  3F0B X;  4KM2 A;  1IA3 A;  4KL9 A;  4M7U A;  1DR4 A;  1RX4 A;  3EEM A;  3TD8 A;  4P3Q A;  3TQA A;  4PSY A;  5CCC A;  3FRE X;  3NZB X;  1DDR A;  4LAH X;  1M7A A;  4P68 A;  3M08 A;  1LY4 A;  4NX7 A;  1DHJ A;  2INQ A;  1M79 A;  1CZ3 A;  2OIP A;  3SRU X;  3INV A;  4Q6A A;  4XRB A;  1CD2 A;  3SRQ X;  1JOL A;  4ELB A;  3QLY A;  3M09 A;  4M6L A;  4H97 A;  3SH2 A;  3FS6 A;  2AZN A;  2B3Z A;  4FGH A;  2ZZA A;  1VDR A;  4DDR A;  5EAJ A;  3JWK A;  3FY8 X;  2BLB A;  3K74 A;  3RG9 A;  4IXF X;  1DYR A;  1JUV A;  5U27 A;  5JA3 A;  4QJZ D;  5HUI A;  1U72 A;  3NXT A;  1RF7 A;  1LUD A;  4DFR A;  4EIL A;  4HA7 A;  3D84 X;  3GI2 A;  2D0K A;  4HOG A;  1RB2 A;  3FQO A;  1AOE A;  2BLC A;  3IRO A;  3CSE A;  3I8A X;  4HA9 A;  3DL6 A;  4G8Z X;  2G6V A;  4KBN A;  4KYA A;  3NRR A;  5HF0 X;  3NTZ A;  1DYI A;  4M6K A;  4QLG A;  5FDA A;  4KJK A;  4X5J A;  2O7P A;  4HOF A;  1RA3 A;  1DR2 A;  4LAE X;  1RX9 A;  1U70 A;  1DG7 A;  3HBB A;  5ECX A;  3IRN A;  4IXG X;  2C2S A;  3QYL A;  1RA1 A;  4I1N A;  5ECC A;  3NZD A;  3JTW A;  4OSG A;  8DFR A;  1VJ3 A;  1KMV A;  2D5N A;  4M7V A;  4KFJ A;  3JSU A;  2GD9 A; 
#chains in the Genus database with same CATH homology
 2C2T A;  1U71 A;  4CD2 A;  4ECK A;  5DFR A;  1DYH A;  4QLE A;  1YHO A;  3TQB A;  1RX2 A;  3JVX A;  1DIS A;  3F0Q X;  3L3R A;  3DAT A;  1PD8 A;  3S3V A;  1IA2 A;  1TDR A;  1DG5 A;  3FL9 A;  4X5G A;  3NU0 A;  3TQ9 A;  3ROA A;  4KAK A;  3D80 A;  3QLR A;  3DL5 A;  1DRE A;  3QLZ A;  3FY9 X;  1RX1 A;  5HPB A;  3SGY A;  1RA2 A;  4TU5 X;  3QGT A;  3S9U A;  1DDS A;  2FZI A;  3VCO A;  1S3W A;  3FYV X;  4PTH A;  1S3Y A;  1S3V A;  2W9T A;  2QK8 A;  4KEB A;  5DXV A;  1DYJ A;  1BZF A;  2W9H A;  1E26 A;  5HF2 X;  3NZA X;  4QJC A;  3JWF A;  3Q1H A;  3CLB A;  2BLA A;  3CL9 A;  1DRB A;  4XE6 X;  4H98 A;  3F8Y A;  4LAG X;  2BL9 A;  3FYW X;  3GYF A;  3RO9 A;  3F0V X;  1OHJ A;  2JYB A;  1PD9 A;  4KD7 A;  3ZPC A;  2CD2 A;  2FZH A;  3NZ9 X;  1MVT A;  2HXV A;  3QL3 A;  2ITH A;  4XT6 A;  1DR7 A;  4H95 A;  3QL0 A;  1DLR A;  4FHB A;  4P66 A;  3UM6 A;  3DFR A;  3K2H A;  2HM9 A;  3GHV A;  1RH3 A;  1BOZ A;  3SA2 A;  3FRD X;  2ANO A;  4PSS A;  3ZPG A;  3FRF X;  4QI9 A;  1RX5 A;  5JG0 X;  1RX7 A;  3GHC A;  3SR5 X;  2W3M A;  3I3R A;  3QG2 A;  4G95 A;  3SRR X;  1DIU A;  3N0H A;  4EIZ A;  4FGG A;  3KJS A;  1DRA A;  4XEC X;  3SAI A;  1RD7 A;  3FRB X;  1DRF A;  3R33 A;  3S7A A;  3SRW X;  4X5F A;  4ELE A;  3QLX A;  5HT5 A;  4GH8 A;  3GHW A;  3EEK A;  1RA8 A;  3JWM A;  2HQP A;  2LF1 A;  5HQY A;  1AI9 A;  1JOM A;  4H96 A;  4XT7 A;  4Q0D A;  1M78 A;  1KMS A;  1DHF A;  3NXO A;  4M2X A;  4I13 A;  3FRA X;  2DHF A;  2W9G A;  3JWC A;  3KGY A;  1SEJ A;  3TQ8 A;  2W3A A;  4M6J A;  4DP3 A;  3KFY A;  3HJ3 A;  3NXY A;  3F91 A;  1S3U A;  4DPH A;  1DR5 A;  4KLX A;  4EJ1 A;  4Q67 A;  4G3M A;  4HOE A;  5HSU A;  4ELG A;  3KJR A;  3F8Z A;  3SRS X;  1J3I A;  1RG7 A;  2FZJ A;  1IA4 A;  4PTJ A;  3DG8 A;  4RGC A;  4EIG A;  1KLK A;  4PDJ A;  3KY8 A;  7DFR A;  2P4G A;  1HFR A;  5HT4 A;  4KJL A;  3E0B A;  1DF7 A;  5U26 A;  1RE7 A;  3F0U X;  4ELF A;  3NZ6 X;  1RX8 A;  1DG8 A;  1DHI A;  3FQF A;  2W3B A;  3UM5 A;  3K47 A;  1RA9 A;  4XT4 A;  5HI6 A;  1AO8 A;  5CC9 A;  3IRM A;  4QHV A;  1OHK A;  1RC4 A;  2H2Q A;  3SQY X;  3LG4 A;  3CD2 A;  2ANQ A;  2OBC A;  1DR1 A;  1DRH A;  3NXV A;  2W3V A;  1DR6 A;  3SA1 A;  3DRC A;  1RB3 A;  3FQC A;  4KY8 A;  3OAF A;  3EEL A;  4X5I A;  3DAU A;  4DPD A;  2DRC A;  1RX6 A;  1J3K A;  1DAJ A;  1PDB A;  3IA5 A;  3K45 A;  5E8Q A;  1HFQ A;  3FL8 A;  5HQZ A;  1DR3 A;  3OCH A;  3F0X X;  5HVB A;  4KJJ A;  4NX6 A;  1ZDR A;  5HVE A;  1MVS A;  3QYO A;  4QLF A;  3NXR A;  3UM8 A;  3NXX A;  4XT8 A;  1J3J A;  4XT5 A;  1HFP A;  3NZC X;  3FQV A;  4IXE D;  4KM0 A;  3FQ0 A;  3JW3 A;  3QLS A;  4LEK X;  4P3R A;  3QFX A;  1D1G A;  1LY3 A;  2W9S A;  1DLS A;  1IA1 A;  4KNE A;  2XW7 A;  2W3W A;  3QLW A;  4OR7 A;  4KY4 A;  3JW5 A;  3F0S X;  4PST A;  4ELH A;  4Q0E A;  4X5H A;  2KGK A;  2CIG A;  3EX8 A;  3FQZ A;  3DGA A;  3IX9 A;  3IA4 A;  3EEJ A;  5HSR A;  3EIG A;  1QZF A;  2L28 A;  6DFR A;  1RX3 A;  3F0B X;  4KM2 A;  1IA3 A;  4KL9 A;  4M7U A;  1DR4 A;  1RX4 A;  3EEM A;  3TD8 A;  4P3Q A;  3TQA A;  4PSY A;  5CCC A;  3FRE X;  3NZB X;  1DDR A;  4LAH X;  1M7A A;  4P68 A;  3M08 A;  1LY4 A;  4NX7 A;  1DHJ A;  2INQ A;  1M79 A;  1CZ3 A;  2OIP A;  3SRU X;  3INV A;  4Q6A A;  4XRB A;  1CD2 A;  3SRQ X;  1JOL A;  4ELB A;  3QLY A;  3M09 A;  4M6L A;  4H97 A;  3SH2 A;  3FS6 A;  2AZN A;  2B3Z A;  4FGH A;  2ZZA A;  1VDR A;  4DDR A;  5EAJ A;  3JWK A;  3FY8 X;  2BLB A;  3K74 A;  3RG9 A;  4IXF X;  1DYR A;  1JUV A;  5U27 A;  5JA3 A;  4QJZ D;  5HUI A;  1U72 A;  3NXT A;  1RF7 A;  1LUD A;  4DFR A;  4EIL A;  4HA7 A;  3D84 X;  3GI2 A;  2D0K A;  4HOG A;  1RB2 A;  3FQO A;  1AOE A;  2BLC A;  3IRO A;  3CSE A;  3I8A X;  4HA9 A;  3DL6 A;  4G8Z X;  2G6V A;  4KBN A;  4KYA A;  3NRR A;  5HF0 X;  3NTZ A;  1DYI A;  4M6K A;  4QLG A;  5FDA A;  4KJK A;  4X5J A;  2O7P A;  4HOF A;  1RA3 A;  1DR2 A;  4LAE X;  1RX9 A;  1U70 A;  1DG7 A;  3HBB A;  5ECX A;  3IRN A;  4IXG X;  2C2S A;  3QYL A;  1RA1 A;  4I1N A;  5ECC A;  3NZD A;  3JTW A;  4OSG A;  8DFR A;  1VJ3 A;  1KMV A;  2D5N A;  4M7V A;  4KFJ A;  3JSU A;  2GD9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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