3NXOA

Perferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPERNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 54
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3nxoA00
3F8ZA 5CC9A 2C2SA 1ZDRA 3QYOA 3FYVX 3M08A 3SRSX 2W3VA 3NTZA 3EEKA 3NXXA 3KY8A 4X5FA 1J3JA 4KFJA 3SRQX 3ZPCA 3S3VA 3DATA 1DREA 3FRBX 3K45A 4PSYA 4QJZD 5HF0X 5E8QA 1KMVA 3F0VX 3JW3A 3UM5A 5U27A 5JG0X 4G3MA 1AO8A 1M79A 3TQ9A 4X5JA 3FL8A 3FS6A 1J3KA 1DISA 4OR7A 1DG5A 6DFRA 3M09A 3KJRA 3NXOA 1RH3A 1JOMA 4KEBA 3NRRA 2B3ZA 3JWFA 3EIGA 8DFRA 3SGYA 7DFRA 1IA1A 2O7PA 2INQA 4HOGA 3JWCA 2FZIA 4ECKA 1PD8A 3SRUX 3SA2A 1DR2A 3CL9A 3SA1A 5JA3A 1J3IA 2W3WA 4PSSA 3EELA 3FQOA 4DPDA 3FRFX 3UM8A 1U72A 3JTWA 2BL9A 1U71A 4XECX 4Q0DA 3D84X 5DFRA 4XT4A 3GHVA 3Q1HA 2C2TA 3HBBA 1QZFA 5ECXA 3E0BA 4PTJA 3SH2A 1KLKA 3FRAX 4KAKA 1DR6A 3QLSA 2W9SA 4H95A 3NXYA 2OIPA 1VDRA 3IA5A 3I3RA 4KJKA 1RA1A 4M2XA 3F0BX 3K47A 3DGAA 4LAEX 1RA8A 1DAJA 4NX7A 3JSUA 1IA3A 1M7AA 3EX8A 1RX8A 2G6VA 4PSTA 3JW5A 3QLYA 4KL9A 4M7UA 3UM6A 4QHVA 4HA9A 5DXVA 3F0QX 3IX9A 4KM2A 1DHFA 1LUDA 1D1GA 2FZHA 3DL5A 4IXED 3F8YA 2FZJA 4M6LA 3EEMA 1AOEA 4RGCA 4P3RA 3CLBA 4Q67A 1RE7A 2HM9A 4G95A 1DDRA 2P4GA 3CSEA 1S3WA 2QK8A 4H98A 1HFQA 1DHJA 3DAUA 5HT5A 1MVSA 4P66A 1YHOA 2CD2A 3DFRA 3IRNA 4DFRA 1DYHA 3VCOA 3KFYA 2DHFA 1SEJA 2ANQA 1MVTA 4KY8A 4LEKX 4QJCA 3FQFA 1DRAA 1JUVA 4P68A 1RC4A 1RX2A 4DDRA 3S9UA 1DG7A 3FY9X 3LG4A 4ELGA 4QLEA 4TU5X 2ITHA 1RA2A 2W9GA 1KMSA 4Q0EA 4ELBA 1OHKA 2JYBA 3QLXA 3NZ9X 1S3YA 1DR7A 1RB2A 2H2QA 3QYLA 4KBNA 3ROAA 4CD2A 3I8AX 3TQBA 1DYRA 1DHIA 1PDBA 3FQ0A 1M78A 3NXVA 3EEJA 1VJ3A 1PD9A 1RX9A 1DLRA 3TQ8A 1DLSA 3JVXA 3QLWA 3K74A 4PTHA 4ELFA 3KJSA 4HOFA 3QFXA 5HQZA 3QLRA 4OSGA 3SAIA 3HJ3A 4HOEA 4KYAA 5HSRA 1JOLA 1RX4A 4QLFA 1HFRA 4EIZA 4KNEA 2W3BA 4XT7A 4X5GA 3D80A 4KY4A 3IA4A 1RB3A 3NZ6X 1E26A 5FDAA 1DDSA 3L3RA 3RG9A 1DF7A 4KJLA 4GH8A 4KJJA 3GI2A 1DR5A 2BLBA 2ANOA 1RX5A 3JWKA 5HI6A 1RF7A 5HQYA 2XW7A 4QI9A 1U70A 1S3UA 5HVEA 2D0KA 3SRRX 4FHBA 1S3VA 1DIUA 1BOZA 4IXGX 1CD2A 1BZFA 3QLZA 4XT5A 1RA3A 3SRWX 5U26A 4XT8A 2LF1A 3FREX 4HA7A 5HVBA 2CIGA 4FGHA 4M6KA 4I1NA 3FQCA 4EIGA 5ECCA 3NZDA 4KLXA 3RO9A 3R33A 1HFPA 2W9TA 1CZ3A 2BLCA 5HSUA 3IROA 1RX6A 1AI9A 1DYIA 3FQVA 3NU0A 2L28A 3GHCA 4H96A 3OAFA 4P3QA 4M7VA 1RD7A 1OHJA 2D5NA 5CCCA 3KGYA 3FQZA 1DRHA 3ZPGA 4Q6AA 1IA4A 3NZAX 3INVA 3NXTA 1IA2A 3F91A 1DRBA 2KGKA 1DYJA 5HUIA 5HT4A 5HPBA 4LAGX 4XE6X 1RA9A 3JWMA 4XRBA 3FRDX 4H97A 1DR3A 2HXVA 1LY3A 3TQAA 3DL6A 3NZBX 3CD2A 4EJ1A 4PDJA 3IRMA 3NXRA 5EAJA 2GD9A 3S7AA 3K2HA 3GHWA 4EILA 2ZZAA 1DRFA 3OCHA 2W3AA 3NZCX 1DR1A 4LAHX 3DG8A 3F0XX 3FY8X 4DPHA 4NX6A 4FGGA 1RX1A 3FYWX 3QL3A 4IXFX 4KD7A 2OBCA 3F0SX 1LY4A 2AZNA 3QGTA 3QL0A 1RX3A 1DG8A 4G8ZX 4ELEA 3TD8A 3QG2A 2HQPA 3FL9A 4X5HA 1DR4A 4ELHA 3N0HA 1RG7A 3SQYX 4I13A 4QLGA 1TDRA 4X5IA 2BLAA 5HF2X 4DP3A 2W9HA 2DRCA 3F0UX 3SR5X 3GYFA 1RX7A 3DRCA 2W3MA 4M6JA 4KM0A 4XT6A
chains in the Genus database with same CATH superfamily
3F8ZA 5CC9A 2C2SA 1ZDRA 3QYOA 3FYVX 3M08A 3SRSX 2W3VA 3NTZA 3EEKA 3NXXA 3KY8A 4X5FA 1J3JA 4KFJA 3SRQX 3ZPCA 3S3VA 3DATA 1DREA 3FRBX 3K45A 4PSYA 4QJZD 5HF0X 5E8QA 1KMVA 3F0VX 3JW3A 3UM5A 5U27A 5JG0X 4G3MA 1AO8A 1M79A 3TQ9A 4X5JA 3FL8A 3FS6A 1J3KA 1DISA 4OR7A 1DG5A 6DFRA 3M09A 3KJRA 3NXOA 1RH3A 1JOMA 4KEBA 3NRRA 2B3ZA 3JWFA 3EIGA 8DFRA 3SGYA 7DFRA 1IA1A 2O7PA 2INQA 4HOGA 3JWCA 2FZIA 4ECKA 1PD8A 3SRUX 3SA2A 1DR2A 3CL9A 3SA1A 5JA3A 1J3IA 2W3WA 4PSSA 3EELA 3FQOA 4DPDA 3FRFX 3UM8A 1U72A 3JTWA 2BL9A 1U71A 4XECX 4Q0DA 3D84X 5DFRA 4XT4A 3GHVA 3Q1HA 2C2TA 3HBBA 1QZFA 5ECXA 3E0BA 4PTJA 3SH2A 1KLKA 3FRAX 4KAKA 1DR6A 3QLSA 2W9SA 4H95A 3NXYA 2OIPA 1VDRA 3IA5A 3I3RA 4KJKA 1RA1A 4M2XA 3F0BX 3K47A 3DGAA 4LAEX 1RA8A 1DAJA 4NX7A 3JSUA 1IA3A 1M7AA 3EX8A 1RX8A 2G6VA 4PSTA 3JW5A 3QLYA 4KL9A 4M7UA 3UM6A 4QHVA 4HA9A 5DXVA 3F0QX 3IX9A 4KM2A 1DHFA 1LUDA 1D1GA 2FZHA 3DL5A 4IXED 3F8YA 2FZJA 4M6LA 3EEMA 1AOEA 4RGCA 4P3RA 3CLBA 4Q67A 1RE7A 2HM9A 4G95A 1DDRA 2P4GA 3CSEA 1S3WA 2QK8A 4H98A 1HFQA 1DHJA 3DAUA 5HT5A 1MVSA 4P66A 1YHOA 2CD2A 3DFRA 3IRNA 4DFRA 1DYHA 3VCOA 3KFYA 2DHFA 1SEJA 2ANQA 1MVTA 4KY8A 4LEKX 4QJCA 3FQFA 1DRAA 1JUVA 4P68A 1RC4A 1RX2A 4DDRA 3S9UA 1DG7A 3FY9X 3LG4A 4ELGA 4QLEA 4TU5X 2ITHA 1RA2A 2W9GA 1KMSA 4Q0EA 4ELBA 1OHKA 2JYBA 3QLXA 3NZ9X 1S3YA 1DR7A 1RB2A 2H2QA 3QYLA 4KBNA 3ROAA 4CD2A 3I8AX 3TQBA 1DYRA 1DHIA 1PDBA 3FQ0A 1M78A 3NXVA 3EEJA 1VJ3A 1PD9A 1RX9A 1DLRA 3TQ8A 1DLSA 3JVXA 3QLWA 3K74A 4PTHA 4ELFA 3KJSA 4HOFA 3QFXA 5HQZA 3QLRA 4OSGA 3SAIA 3HJ3A 4HOEA 4KYAA 5HSRA 1JOLA 1RX4A 4QLFA 1HFRA 4EIZA 4KNEA 2W3BA 4XT7A 4X5GA 3D80A 4KY4A 3IA4A 1RB3A 3NZ6X 1E26A 5FDAA 1DDSA 3L3RA 3RG9A 1DF7A 4KJLA 4GH8A 4KJJA 3GI2A 1DR5A 2BLBA 2ANOA 1RX5A 3JWKA 5HI6A 1RF7A 5HQYA 2XW7A 4QI9A 1U70A 1S3UA 5HVEA 2D0KA 3SRRX 4FHBA 1S3VA 1DIUA 1BOZA 4IXGX 1CD2A 1BZFA 3QLZA 4XT5A 1RA3A 3SRWX 5U26A 4XT8A 2LF1A 3FREX 4HA7A 5HVBA 2CIGA 4FGHA 4M6KA 4I1NA 3FQCA 4EIGA 5ECCA 3NZDA 4KLXA 3RO9A 3R33A 1HFPA 2W9TA 1CZ3A 2BLCA 5HSUA 3IROA 1RX6A 1AI9A 1DYIA 3FQVA 3NU0A 2L28A 3GHCA 4H96A 3OAFA 4P3QA 4M7VA 1RD7A 1OHJA 2D5NA 5CCCA 3KGYA 3FQZA 1DRHA 3ZPGA 4Q6AA 1IA4A 3NZAX 3INVA 3NXTA 1IA2A 3F91A 1DRBA 2KGKA 1DYJA 5HUIA 5HT4A 5HPBA 4LAGX 4XE6X 1RA9A 3JWMA 4XRBA 3FRDX 4H97A 1DR3A 2HXVA 1LY3A 3TQAA 3DL6A 3NZBX 3CD2A 4EJ1A 4PDJA 3IRMA 3NXRA 5EAJA 2GD9A 3S7AA 3K2HA 3GHWA 4EILA 2ZZAA 1DRFA 3OCHA 2W3AA 3NZCX 1DR1A 4LAHX 3DG8A 3F0XX 3FY8X 4DPHA 4NX6A 4FGGA 1RX1A 3FYWX 3QL3A 4IXFX 4KD7A 2OBCA 3F0SX 1LY4A 2AZNA 3QGTA 3QL0A 1RX3A 1DG8A 4G8ZX 4ELEA 3TD8A 3QG2A 2HQPA 3FL9A 4X5HA 1DR4A 4ELHA 3N0HA 1RG7A 3SQYX 4I13A 4QLGA 1TDRA 4X5IA 2BLAA 5HF2X 4DP3A 2W9HA 2DRCA 3F0UX 3SR5X 3GYFA 1RX7A 3DRCA 2W3MA 4M6JA 4KM0A 4XT6A
chains in the Genus database with same CATH topology
3F8ZA 5CC9A 2C2SA 1ZDRA 3QYOA 3FYVX 3M08A 3SRSX 2W3VA 3NTZA 3EEKA 3NXXA 3KY8A 4X5FA 1J3JA 4KFJA 3SRQX 3ZPCA 3S3VA 3DATA 1DREA 3FRBX 3K45A 4PSYA 4QJZD 5HF0X 5E8QA 1KMVA 3F0VX 3JW3A 3UM5A 5U27A 5JG0X 4G3MA 1AO8A 1M79A 3TQ9A 4X5JA 3FL8A 3FS6A 1J3KA 1DISA 4OR7A 1DG5A 6DFRA 3M09A 3KJRA 3NXOA 1RH3A 1JOMA 4KEBA 3NRRA 2B3ZA 3JWFA 3EIGA 8DFRA 3SGYA 7DFRA 1IA1A 2O7PA 2INQA 4HOGA 3JWCA 2FZIA 4ECKA 1PD8A 3SRUX 3SA2A 1DR2A 3CL9A 3SA1A 5JA3A 1J3IA 2W3WA 4PSSA 3EELA 3FQOA 4DPDA 3FRFX 3UM8A 1U72A 3JTWA 2BL9A 1U71A 4XECX 4Q0DA 3D84X 5DFRA 4XT4A 3GHVA 3Q1HA 2C2TA 3HBBA 1QZFA 5ECXA 3E0BA 4PTJA 3SH2A 1KLKA 3FRAX 4KAKA 1DR6A 3QLSA 2W9SA 4H95A 3NXYA 2OIPA 1VDRA 3IA5A 3I3RA 4KJKA 1RA1A 4M2XA 3F0BX 3K47A 3DGAA 4LAEX 1RA8A 1DAJA 4NX7A 3JSUA 1IA3A 1M7AA 3EX8A 1RX8A 2G6VA 4PSTA 3JW5A 3QLYA 4KL9A 4M7UA 3UM6A 4QHVA 4HA9A 5DXVA 3F0QX 3IX9A 4KM2A 1DHFA 1LUDA 1D1GA 2FZHA 3DL5A 4IXED 3F8YA 2FZJA 4M6LA 3EEMA 1AOEA 4RGCA 4P3RA 3CLBA 4Q67A 1RE7A 2HM9A 4G95A 1DDRA 2P4GA 3CSEA 1S3WA 2QK8A 4H98A 1HFQA 1DHJA 3DAUA 5HT5A 1MVSA 4P66A 1YHOA 2CD2A 3DFRA 3IRNA 4DFRA 1DYHA 3VCOA 3KFYA 2DHFA 1SEJA 2ANQA 1MVTA 4KY8A 4LEKX 4QJCA 3FQFA 1DRAA 1JUVA 4P68A 1RC4A 1RX2A 4DDRA 3S9UA 1DG7A 3FY9X 3LG4A 4ELGA 4QLEA 4TU5X 2ITHA 1RA2A 2W9GA 1KMSA 4Q0EA 4ELBA 1OHKA 2JYBA 3QLXA 3NZ9X 1S3YA 1DR7A 1RB2A 2H2QA 3QYLA 4KBNA 3ROAA 4CD2A 3I8AX 3TQBA 1DYRA 1DHIA 1PDBA 3FQ0A 1M78A 3NXVA 3EEJA 1VJ3A 1PD9A 1RX9A 1DLRA 3TQ8A 1DLSA 3JVXA 3QLWA 3K74A 4PTHA 4ELFA 3KJSA 4HOFA 3QFXA 5HQZA 3QLRA 4OSGA 3SAIA 3HJ3A 4HOEA 4KYAA 5HSRA 1JOLA 1RX4A 4QLFA 1HFRA 4EIZA 4KNEA 2W3BA 4XT7A 4X5GA 3D80A 4KY4A 3IA4A 1RB3A 3NZ6X 1E26A 5FDAA 1DDSA 3L3RA 3RG9A 1DF7A 4KJLA 4GH8A 4KJJA 3GI2A 1DR5A 2BLBA 2ANOA 1RX5A 3JWKA 5HI6A 1RF7A 5HQYA 2XW7A 4QI9A 1U70A 1S3UA 5HVEA 2D0KA 3SRRX 4FHBA 1S3VA 1DIUA 1BOZA 4IXGX 1CD2A 1BZFA 3QLZA 4XT5A 1RA3A 3SRWX 5U26A 4XT8A 2LF1A 3FREX 4HA7A 5HVBA 2CIGA 4FGHA 4M6KA 4I1NA 3FQCA 4EIGA 5ECCA 3NZDA 4KLXA 3RO9A 3R33A 1HFPA 2W9TA 1CZ3A 2BLCA 5HSUA 3IROA 1RX6A 1AI9A 1DYIA 3FQVA 3NU0A 2L28A 3GHCA 4H96A 3OAFA 4P3QA 4M7VA 1RD7A 1OHJA 2D5NA 5CCCA 3KGYA 3FQZA 1DRHA 3ZPGA 4Q6AA 1IA4A 3NZAX 3INVA 3NXTA 1IA2A 3F91A 1DRBA 2KGKA 1DYJA 5HUIA 5HT4A 5HPBA 4LAGX 4XE6X 1RA9A 3JWMA 4XRBA 3FRDX 4H97A 1DR3A 2HXVA 1LY3A 3TQAA 3DL6A 3NZBX 3CD2A 4EJ1A 4PDJA 3IRMA 3NXRA 5EAJA 2GD9A 3S7AA 3K2HA 3GHWA 4EILA 2ZZAA 1DRFA 3OCHA 2W3AA 3NZCX 1DR1A 4LAHX 3DG8A 3F0XX 3FY8X 4DPHA 4NX6A 4FGGA 1RX1A 3FYWX 3QL3A 4IXFX 4KD7A 2OBCA 3F0SX 1LY4A 2AZNA 3QGTA 3QL0A 1RX3A 1DG8A 4G8ZX 4ELEA 3TD8A 3QG2A 2HQPA 3FL9A 4X5HA 1DR4A 4ELHA 3N0HA 1RG7A 3SQYX 4I13A 4QLGA 1TDRA 4X5IA 2BLAA 5HF2X 4DP3A 2W9HA 2DRCA 3F0UX 3SR5X 3GYFA 1RX7A 3DRCA 2W3MA 4M6JA 4KM0A 4XT6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F8Z A;  5CC9 A;  2C2S A;  1ZDR A;  3QYO A;  3FYV X;  3M08 A;  3SRS X;  2W3V A;  3NTZ A;  3EEK A;  3NXX A;  3KY8 A;  4X5F A;  1J3J A;  4KFJ A;  3SRQ X;  3ZPC A;  3S3V A;  3DAT A;  1DRE A;  3FRB X;  3K45 A;  4PSY A;  4QJZ D;  5HF0 X;  5E8Q A;  1KMV A;  3F0V X;  3JW3 A;  3UM5 A;  5U27 A;  5JG0 X;  4G3M A;  1AO8 A;  1M79 A;  3TQ9 A;  4X5J A;  3FL8 A;  3FS6 A;  1J3K A;  1DIS A;  4OR7 A;  1DG5 A;  6DFR A;  3M09 A;  3KJR A;  3NXO A;  1RH3 A;  1JOM A;  4KEB A;  3NRR A;  2B3Z A;  3JWF A;  3EIG A;  8DFR A;  3SGY A;  7DFR A;  1IA1 A;  2O7P A;  2INQ A;  4HOG A;  3JWC A;  2FZI A;  4ECK A;  1PD8 A;  3SRU X;  3SA2 A;  1DR2 A;  3CL9 A;  3SA1 A;  5JA3 A;  1J3I A;  2W3W A;  4PSS A;  3EEL A;  3FQO A;  4DPD A;  3FRF X;  3UM8 A;  1U72 A;  3JTW A;  2BL9 A;  1U71 A;  4XEC X;  4Q0D A;  3D84 X;  5DFR A;  4XT4 A;  3GHV A;  3Q1H A;  2C2T A;  3HBB A;  1QZF A;  5ECX A;  3E0B A;  4PTJ A;  3SH2 A;  1KLK A;  3FRA X;  4KAK A;  1DR6 A;  3QLS A;  2W9S A;  4H95 A;  3NXY A;  2OIP A;  1VDR A;  3IA5 A;  3I3R A;  4KJK A;  1RA1 A;  4M2X A;  3F0B X;  3K47 A;  3DGA A;  4LAE X;  1RA8 A;  1DAJ A;  4NX7 A;  3JSU A;  1IA3 A;  1M7A A;  3EX8 A;  1RX8 A;  2G6V A;  4PST A;  3JW5 A;  3QLY A;  4KL9 A;  4M7U A;  3UM6 A;  4QHV A;  4HA9 A;  5DXV A;  3F0Q X;  3IX9 A;  4KM2 A;  1DHF A;  1LUD A;  1D1G A;  2FZH A;  3DL5 A;  4IXE D;  3F8Y A;  2FZJ A;  4M6L A;  3EEM A;  1AOE A;  4RGC A;  4P3R A;  3CLB A;  4Q67 A;  1RE7 A;  2HM9 A;  4G95 A;  1DDR A;  2P4G A;  3CSE A;  1S3W A;  2QK8 A;  4H98 A;  1HFQ A;  1DHJ A;  3DAU A;  5HT5 A;  1MVS A;  4P66 A;  1YHO A;  2CD2 A;  3DFR A;  3IRN A;  4DFR A;  1DYH A;  3VCO A;  3KFY A;  2DHF A;  1SEJ A;  2ANQ A;  1MVT A;  4KY8 A;  4LEK X;  4QJC A;  3FQF A;  1DRA A;  1JUV A;  4P68 A;  1RC4 A;  1RX2 A;  4DDR A;  3S9U A;  1DG7 A;  3FY9 X;  3LG4 A;  4ELG A;  4QLE A;  4TU5 X;  2ITH A;  1RA2 A;  2W9G A;  1KMS A;  4Q0E A;  4ELB A;  1OHK A;  2JYB A;  3QLX A;  3NZ9 X;  1S3Y A;  1DR7 A;  1RB2 A;  2H2Q A;  3QYL A;  4KBN A;  3ROA A;  4CD2 A;  3I8A X;  3TQB A;  1DYR A;  1DHI A;  1PDB A;  3FQ0 A;  1M78 A;  3NXV A;  3EEJ A;  1VJ3 A;  1PD9 A;  1RX9 A;  1DLR A;  3TQ8 A;  1DLS A;  3JVX A;  3QLW A;  3K74 A;  4PTH A;  4ELF A;  3KJS A;  4HOF A;  3QFX A;  5HQZ A;  3QLR A;  4OSG A;  3SAI A;  3HJ3 A;  4HOE A;  4KYA A;  5HSR A;  1JOL A;  1RX4 A;  4QLF A;  1HFR A;  4EIZ A;  4KNE A;  2W3B A;  4XT7 A;  4X5G A;  3D80 A;  4KY4 A;  3IA4 A;  1RB3 A;  3NZ6 X;  1E26 A;  5FDA A;  1DDS A;  3L3R A;  3RG9 A;  1DF7 A;  4KJL A;  4GH8 A;  4KJJ A;  3GI2 A;  1DR5 A;  2BLB A;  2ANO A;  1RX5 A;  3JWK A;  5HI6 A;  1RF7 A;  5HQY A;  2XW7 A;  4QI9 A;  1U70 A;  1S3U A;  5HVE A;  2D0K A;  3SRR X;  4FHB A;  1S3V A;  1DIU A;  1BOZ A;  4IXG X;  1CD2 A;  1BZF A;  3QLZ A;  4XT5 A;  1RA3 A;  3SRW X;  5U26 A;  4XT8 A;  2LF1 A;  3FRE X;  4HA7 A;  5HVB A;  2CIG A;  4FGH A;  4M6K A;  4I1N A;  3FQC A;  4EIG A;  5ECC A;  3NZD A;  4KLX A;  3RO9 A;  3R33 A;  1HFP A;  2W9T A;  1CZ3 A;  2BLC A;  5HSU A;  3IRO A;  1RX6 A;  1AI9 A;  1DYI A;  3FQV A;  3NU0 A;  2L28 A;  3GHC A;  4H96 A;  3OAF A;  4P3Q A;  4M7V A;  1RD7 A;  1OHJ A;  2D5N A;  5CCC A;  3KGY A;  3FQZ A;  1DRH A;  3ZPG A;  4Q6A A;  1IA4 A;  3NZA X;  3INV A;  3NXT A;  1IA2 A;  3F91 A;  1DRB A;  2KGK A;  1DYJ A;  5HUI A;  5HT4 A;  5HPB A;  4LAG X;  4XE6 X;  1RA9 A;  3JWM A;  4XRB A;  3FRD X;  4H97 A;  1DR3 A;  2HXV A;  1LY3 A;  3TQA A;  3DL6 A;  3NZB X;  3CD2 A;  4EJ1 A;  4PDJ A;  3IRM A;  3NXR A;  5EAJ A;  2GD9 A;  3S7A A;  3K2H A;  3GHW A;  4EIL A;  2ZZA A;  1DRF A;  3OCH A;  2W3A A;  3NZC X;  1DR1 A;  4LAH X;  3DG8 A;  3F0X X;  3FY8 X;  4DPH A;  4NX6 A;  4FGG A;  1RX1 A;  3FYW X;  3QL3 A;  4IXF X;  4KD7 A;  2OBC A;  3F0S X;  1LY4 A;  2AZN A;  3QGT A;  3QL0 A;  1RX3 A;  1DG8 A;  4G8Z X;  4ELE A;  3TD8 A;  3QG2 A;  2HQP A;  3FL9 A;  4X5H A;  1DR4 A;  4ELH A;  3N0H A;  1RG7 A;  3SQY X;  4I13 A;  4QLG A;  1TDR A;  4X5I A;  2BLA A;  5HF2 X;  4DP3 A;  2W9H A;  2DRC A;  3F0U X;  3SR5 X;  3GYF A;  1RX7 A;  3DRC A;  2W3M A;  4M6J A;  4KM0 A;  4XT6 A; 
#chains in the Genus database with same CATH topology
 3F8Z A;  5CC9 A;  2C2S A;  1ZDR A;  3QYO A;  3FYV X;  3M08 A;  3SRS X;  2W3V A;  3NTZ A;  3EEK A;  3NXX A;  3KY8 A;  4X5F A;  1J3J A;  4KFJ A;  3SRQ X;  3ZPC A;  3S3V A;  3DAT A;  1DRE A;  3FRB X;  3K45 A;  4PSY A;  4QJZ D;  5HF0 X;  5E8Q A;  1KMV A;  3F0V X;  3JW3 A;  3UM5 A;  5U27 A;  5JG0 X;  4G3M A;  1AO8 A;  1M79 A;  3TQ9 A;  4X5J A;  3FL8 A;  3FS6 A;  1J3K A;  1DIS A;  4OR7 A;  1DG5 A;  6DFR A;  3M09 A;  3KJR A;  3NXO A;  1RH3 A;  1JOM A;  4KEB A;  3NRR A;  2B3Z A;  3JWF A;  3EIG A;  8DFR A;  3SGY A;  7DFR A;  1IA1 A;  2O7P A;  2INQ A;  4HOG A;  3JWC A;  2FZI A;  4ECK A;  1PD8 A;  3SRU X;  3SA2 A;  1DR2 A;  3CL9 A;  3SA1 A;  5JA3 A;  1J3I A;  2W3W A;  4PSS A;  3EEL A;  3FQO A;  4DPD A;  3FRF X;  3UM8 A;  1U72 A;  3JTW A;  2BL9 A;  1U71 A;  4XEC X;  4Q0D A;  3D84 X;  5DFR A;  4XT4 A;  3GHV A;  3Q1H A;  2C2T A;  3HBB A;  1QZF A;  5ECX A;  3E0B A;  4PTJ A;  3SH2 A;  1KLK A;  3FRA X;  4KAK A;  1DR6 A;  3QLS A;  2W9S A;  4H95 A;  3NXY A;  2OIP A;  1VDR A;  3IA5 A;  3I3R A;  4KJK A;  1RA1 A;  4M2X A;  3F0B X;  3K47 A;  3DGA A;  4LAE X;  1RA8 A;  1DAJ A;  4NX7 A;  3JSU A;  1IA3 A;  1M7A A;  3EX8 A;  1RX8 A;  2G6V A;  4PST A;  3JW5 A;  3QLY A;  4KL9 A;  4M7U A;  3UM6 A;  4QHV A;  4HA9 A;  5DXV A;  3F0Q X;  3IX9 A;  4KM2 A;  1DHF A;  1LUD A;  1D1G A;  2FZH A;  3DL5 A;  4IXE D;  3F8Y A;  2FZJ A;  4M6L A;  3EEM A;  1AOE A;  4RGC A;  4P3R A;  3CLB A;  4Q67 A;  1RE7 A;  2HM9 A;  4G95 A;  1DDR A;  2P4G A;  3CSE A;  1S3W A;  2QK8 A;  4H98 A;  1HFQ A;  1DHJ A;  3DAU A;  5HT5 A;  1MVS A;  4P66 A;  1YHO A;  2CD2 A;  3DFR A;  3IRN A;  4DFR A;  1DYH A;  3VCO A;  3KFY A;  2DHF A;  1SEJ A;  2ANQ A;  1MVT A;  4KY8 A;  4LEK X;  4QJC A;  3FQF A;  1DRA A;  1JUV A;  4P68 A;  1RC4 A;  1RX2 A;  4DDR A;  3S9U A;  1DG7 A;  3FY9 X;  3LG4 A;  4ELG A;  4QLE A;  4TU5 X;  2ITH A;  1RA2 A;  2W9G A;  1KMS A;  4Q0E A;  4ELB A;  1OHK A;  2JYB A;  3QLX A;  3NZ9 X;  1S3Y A;  1DR7 A;  1RB2 A;  2H2Q A;  3QYL A;  4KBN A;  3ROA A;  4CD2 A;  3I8A X;  3TQB A;  1DYR A;  1DHI A;  1PDB A;  3FQ0 A;  1M78 A;  3NXV A;  3EEJ A;  1VJ3 A;  1PD9 A;  1RX9 A;  1DLR A;  3TQ8 A;  1DLS A;  3JVX A;  3QLW A;  3K74 A;  4PTH A;  4ELF A;  3KJS A;  4HOF A;  3QFX A;  5HQZ A;  3QLR A;  4OSG A;  3SAI A;  3HJ3 A;  4HOE A;  4KYA A;  5HSR A;  1JOL A;  1RX4 A;  4QLF A;  1HFR A;  4EIZ A;  4KNE A;  2W3B A;  4XT7 A;  4X5G A;  3D80 A;  4KY4 A;  3IA4 A;  1RB3 A;  3NZ6 X;  1E26 A;  5FDA A;  1DDS A;  3L3R A;  3RG9 A;  1DF7 A;  4KJL A;  4GH8 A;  4KJJ A;  3GI2 A;  1DR5 A;  2BLB A;  2ANO A;  1RX5 A;  3JWK A;  5HI6 A;  1RF7 A;  5HQY A;  2XW7 A;  4QI9 A;  1U70 A;  1S3U A;  5HVE A;  2D0K A;  3SRR X;  4FHB A;  1S3V A;  1DIU A;  1BOZ A;  4IXG X;  1CD2 A;  1BZF A;  3QLZ A;  4XT5 A;  1RA3 A;  3SRW X;  5U26 A;  4XT8 A;  2LF1 A;  3FRE X;  4HA7 A;  5HVB A;  2CIG A;  4FGH A;  4M6K A;  4I1N A;  3FQC A;  4EIG A;  5ECC A;  3NZD A;  4KLX A;  3RO9 A;  3R33 A;  1HFP A;  2W9T A;  1CZ3 A;  2BLC A;  5HSU A;  3IRO A;  1RX6 A;  1AI9 A;  1DYI A;  3FQV A;  3NU0 A;  2L28 A;  3GHC A;  4H96 A;  3OAF A;  4P3Q A;  4M7V A;  1RD7 A;  1OHJ A;  2D5N A;  5CCC A;  3KGY A;  3FQZ A;  1DRH A;  3ZPG A;  4Q6A A;  1IA4 A;  3NZA X;  3INV A;  3NXT A;  1IA2 A;  3F91 A;  1DRB A;  2KGK A;  1DYJ A;  5HUI A;  5HT4 A;  5HPB A;  4LAG X;  4XE6 X;  1RA9 A;  3JWM A;  4XRB A;  3FRD X;  4H97 A;  1DR3 A;  2HXV A;  1LY3 A;  3TQA A;  3DL6 A;  3NZB X;  3CD2 A;  4EJ1 A;  4PDJ A;  3IRM A;  3NXR A;  5EAJ A;  2GD9 A;  3S7A A;  3K2H A;  3GHW A;  4EIL A;  2ZZA A;  1DRF A;  3OCH A;  2W3A A;  3NZC X;  1DR1 A;  4LAH X;  3DG8 A;  3F0X X;  3FY8 X;  4DPH A;  4NX6 A;  4FGG A;  1RX1 A;  3FYW X;  3QL3 A;  4IXF X;  4KD7 A;  2OBC A;  3F0S X;  1LY4 A;  2AZN A;  3QGT A;  3QL0 A;  1RX3 A;  1DG8 A;  4G8Z X;  4ELE A;  3TD8 A;  3QG2 A;  2HQP A;  3FL9 A;  4X5H A;  1DR4 A;  4ELH A;  3N0H A;  1RG7 A;  3SQY X;  4I13 A;  4QLG A;  1TDR A;  4X5I A;  2BLA A;  5HF2 X;  4DP3 A;  2W9H A;  2DRC A;  3F0U X;  3SR5 X;  3GYF A;  1RX7 A;  3DRC A;  2W3M A;  4M6J A;  4KM0 A;  4XT6 A; 
#chains in the Genus database with same CATH homology
 3F8Z A;  5CC9 A;  2C2S A;  1ZDR A;  3QYO A;  3FYV X;  3M08 A;  3SRS X;  2W3V A;  3NTZ A;  3EEK A;  3NXX A;  3KY8 A;  4X5F A;  1J3J A;  4KFJ A;  3SRQ X;  3ZPC A;  3S3V A;  3DAT A;  1DRE A;  3FRB X;  3K45 A;  4PSY A;  4QJZ D;  5HF0 X;  5E8Q A;  1KMV A;  3F0V X;  3JW3 A;  3UM5 A;  5U27 A;  5JG0 X;  4G3M A;  1AO8 A;  1M79 A;  3TQ9 A;  4X5J A;  3FL8 A;  3FS6 A;  1J3K A;  1DIS A;  4OR7 A;  1DG5 A;  6DFR A;  3M09 A;  3KJR A;  3NXO A;  1RH3 A;  1JOM A;  4KEB A;  3NRR A;  2B3Z A;  3JWF A;  3EIG A;  8DFR A;  3SGY A;  7DFR A;  1IA1 A;  2O7P A;  2INQ A;  4HOG A;  3JWC A;  2FZI A;  4ECK A;  1PD8 A;  3SRU X;  3SA2 A;  1DR2 A;  3CL9 A;  3SA1 A;  5JA3 A;  1J3I A;  2W3W A;  4PSS A;  3EEL A;  3FQO A;  4DPD A;  3FRF X;  3UM8 A;  1U72 A;  3JTW A;  2BL9 A;  1U71 A;  4XEC X;  4Q0D A;  3D84 X;  5DFR A;  4XT4 A;  3GHV A;  3Q1H A;  2C2T A;  3HBB A;  1QZF A;  5ECX A;  3E0B A;  4PTJ A;  3SH2 A;  1KLK A;  3FRA X;  4KAK A;  1DR6 A;  3QLS A;  2W9S A;  4H95 A;  3NXY A;  2OIP A;  1VDR A;  3IA5 A;  3I3R A;  4KJK A;  1RA1 A;  4M2X A;  3F0B X;  3K47 A;  3DGA A;  4LAE X;  1RA8 A;  1DAJ A;  4NX7 A;  3JSU A;  1IA3 A;  1M7A A;  3EX8 A;  1RX8 A;  2G6V A;  4PST A;  3JW5 A;  3QLY A;  4KL9 A;  4M7U A;  3UM6 A;  4QHV A;  4HA9 A;  5DXV A;  3F0Q X;  3IX9 A;  4KM2 A;  1DHF A;  1LUD A;  1D1G A;  2FZH A;  3DL5 A;  4IXE D;  3F8Y A;  2FZJ A;  4M6L A;  3EEM A;  1AOE A;  4RGC A;  4P3R A;  3CLB A;  4Q67 A;  1RE7 A;  2HM9 A;  4G95 A;  1DDR A;  2P4G A;  3CSE A;  1S3W A;  2QK8 A;  4H98 A;  1HFQ A;  1DHJ A;  3DAU A;  5HT5 A;  1MVS A;  4P66 A;  1YHO A;  2CD2 A;  3DFR A;  3IRN A;  4DFR A;  1DYH A;  3VCO A;  3KFY A;  2DHF A;  1SEJ A;  2ANQ A;  1MVT A;  4KY8 A;  4LEK X;  4QJC A;  3FQF A;  1DRA A;  1JUV A;  4P68 A;  1RC4 A;  1RX2 A;  4DDR A;  3S9U A;  1DG7 A;  3FY9 X;  3LG4 A;  4ELG A;  4QLE A;  4TU5 X;  2ITH A;  1RA2 A;  2W9G A;  1KMS A;  4Q0E A;  4ELB A;  1OHK A;  2JYB A;  3QLX A;  3NZ9 X;  1S3Y A;  1DR7 A;  1RB2 A;  2H2Q A;  3QYL A;  4KBN A;  3ROA A;  4CD2 A;  3I8A X;  3TQB A;  1DYR A;  1DHI A;  1PDB A;  3FQ0 A;  1M78 A;  3NXV A;  3EEJ A;  1VJ3 A;  1PD9 A;  1RX9 A;  1DLR A;  3TQ8 A;  1DLS A;  3JVX A;  3QLW A;  3K74 A;  4PTH A;  4ELF A;  3KJS A;  4HOF A;  3QFX A;  5HQZ A;  3QLR A;  4OSG A;  3SAI A;  3HJ3 A;  4HOE A;  4KYA A;  5HSR A;  1JOL A;  1RX4 A;  4QLF A;  1HFR A;  4EIZ A;  4KNE A;  2W3B A;  4XT7 A;  4X5G A;  3D80 A;  4KY4 A;  3IA4 A;  1RB3 A;  3NZ6 X;  1E26 A;  5FDA A;  1DDS A;  3L3R A;  3RG9 A;  1DF7 A;  4KJL A;  4GH8 A;  4KJJ A;  3GI2 A;  1DR5 A;  2BLB A;  2ANO A;  1RX5 A;  3JWK A;  5HI6 A;  1RF7 A;  5HQY A;  2XW7 A;  4QI9 A;  1U70 A;  1S3U A;  5HVE A;  2D0K A;  3SRR X;  4FHB A;  1S3V A;  1DIU A;  1BOZ A;  4IXG X;  1CD2 A;  1BZF A;  3QLZ A;  4XT5 A;  1RA3 A;  3SRW X;  5U26 A;  4XT8 A;  2LF1 A;  3FRE X;  4HA7 A;  5HVB A;  2CIG A;  4FGH A;  4M6K A;  4I1N A;  3FQC A;  4EIG A;  5ECC A;  3NZD A;  4KLX A;  3RO9 A;  3R33 A;  1HFP A;  2W9T A;  1CZ3 A;  2BLC A;  5HSU A;  3IRO A;  1RX6 A;  1AI9 A;  1DYI A;  3FQV A;  3NU0 A;  2L28 A;  3GHC A;  4H96 A;  3OAF A;  4P3Q A;  4M7V A;  1RD7 A;  1OHJ A;  2D5N A;  5CCC A;  3KGY A;  3FQZ A;  1DRH A;  3ZPG A;  4Q6A A;  1IA4 A;  3NZA X;  3INV A;  3NXT A;  1IA2 A;  3F91 A;  1DRB A;  2KGK A;  1DYJ A;  5HUI A;  5HT4 A;  5HPB A;  4LAG X;  4XE6 X;  1RA9 A;  3JWM A;  4XRB A;  3FRD X;  4H97 A;  1DR3 A;  2HXV A;  1LY3 A;  3TQA A;  3DL6 A;  3NZB X;  3CD2 A;  4EJ1 A;  4PDJ A;  3IRM A;  3NXR A;  5EAJ A;  2GD9 A;  3S7A A;  3K2H A;  3GHW A;  4EIL A;  2ZZA A;  1DRF A;  3OCH A;  2W3A A;  3NZC X;  1DR1 A;  4LAH X;  3DG8 A;  3F0X X;  3FY8 X;  4DPH A;  4NX6 A;  4FGG A;  1RX1 A;  3FYW X;  3QL3 A;  4IXF X;  4KD7 A;  2OBC A;  3F0S X;  1LY4 A;  2AZN A;  3QGT A;  3QL0 A;  1RX3 A;  1DG8 A;  4G8Z X;  4ELE A;  3TD8 A;  3QG2 A;  2HQP A;  3FL9 A;  4X5H A;  1DR4 A;  4ELH A;  3N0H A;  1RG7 A;  3SQY X;  4I13 A;  4QLG A;  1TDR A;  4X5I A;  2BLA A;  5HF2 X;  4DP3 A;  2W9H A;  2DRC A;  3F0U X;  3SR5 X;  3GYF A;  1RX7 A;  3DRC A;  2W3M A;  4M6J A;  4KM0 A;  4XT6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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