3NXRA

Perferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 57
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3nxrA00
4X5FA 1S3UA 1RB3A 2XW7A 4TU5X 3QLYA 3F0VX 3FRBX 3OAFA 5HQZA 1CD2A 1DRAA 2W3MA 2W3WA 4Q0EA 4KJKA 2BLAA 4KY4A 3Q1HA 3TD8A 2AZNA 3ROAA 3NXVA 2W3AA 4QI9A 1DR2A 3F8YA 3F0UX 2W9GA 3F91A 1RA8A 1DISA 3KGYA 4LAGX 3NZDA 3FL8A 4Q67A 1U71A 4Q6AA 1RX2A 3F0BX 3GYFA 4DP3A 1PDBA 3IROA 3SAIA 1DR5A 3EIGA 5HSUA 3FREX 4KFJA 1M7AA 4H97A 5U27A 2JYBA 5HPBA 2DRCA 3QLWA 1DYRA 5FDAA 3FY8X 1RB2A 3QL3A 3JWKA 2BL9A 2C2TA 1DLRA 4HA7A 1IA2A 1DRFA 3SGYA 4ELHA 3D84X 1RD7A 3ZPGA 1HFRA 4M6LA 3FL9A 3QYOA 3NZ9X 4EILA 3L3RA 4QHVA 3F0SX 3FQFA 1HFQA 3FQZA 4NX7A 2ANOA 4EIZA 3FS6A 4OR7A 4PTHA 4HA9A 1RA3A 3E0BA 1AI9A 3FQOA 4LAHX 4XT8A 3LG4A 3FQCA 4G3MA 5JA3A 3FQVA 3NXRA 4GH8A 3TQBA 4KYAA 2QK8A 8DFRA 4DDRA 4PTJA 1HFPA 3TQ9A 4FHBA 5HF0X 1LUDA 1QZFA 3SRUX 1J3JA 1JOLA 4IXED 3GI2A 3CSEA 3SH2A 3SRWX 4P3RA 3DL5A 2W3VA 4FGGA 1DG5A 2HXVA 3DFRA 3R33A 4KJLA 4IXGX 1OHKA 3FRDX 1S3WA 2W9TA 3FRAX 1TDRA 3FYWX 3QG2A 1RX1A 1E26A 3JTWA 5U26A 4KAKA 4QLEA 3QYLA 1LY4A 4G95A 3FRFX 3IA5A 4M7UA 1JUVA 2FZJA 1PD9A 3DGAA 1BZFA 1DR4A 2HQPA 3N0HA 3QLXA 5E8QA 3RG9A 1RX4A 2W3BA 4I1NA 1KMVA 2H2QA 4LEKX 4EIGA 1DIUA 3S7AA 5DXVA 1RA1A 3I8AX 2OBCA 1MVSA 3KJSA 4Q0DA 2BLCA 1DG8A 3QL0A 1DLSA 2GD9A 1SEJA 1CZ3A 1DR3A 5HF2X 1DHJA 1IA3A 5EAJA 3I3RA 4DPDA 3EEMA 2HM9A 3M09A 1RC4A 2O7PA 3JW5A 1JOMA 4ELBA 3IRMA 2FZHA 1DYIA 2G6VA 4M2XA 1S3YA 3F8ZA 4HOGA 2D5NA 4ELFA 5CCCA 5HVBA 1J3IA 1RF7A 1RX9A 1S3VA 3JSUA 2W9HA 4XT5A 3FY9X 5HT4A 5CC9A 1VDRA 3NU0A 3K45A 3QLZA 3SA1A 3KFYA 3DL6A 3KJRA 1DF7A 4QJZD 3UM6A 6DFRA 2KGKA 4KM0A 4QJCA 7DFRA 3ZPCA 4X5JA 4HOFA 1DRHA 1RA2A 4FGHA 3JWMA 5HUIA 3GHCA 5ECXA 3NTZA 1AO8A 3JWCA 4XRBA 5DFRA 1RE7A 1YHOA 3JW3A 3D80A 4KM2A 4P3QA 3QLSA 3HBBA 1LY3A 3TQAA 4QLGA 1RX7A 1D1GA 4XECX 2L28A 4KL9A 3SR5X 2OIPA 4EJ1A 3UM8A 5HQYA 4ELEA 5HVEA 1DYHA 1RX3A 2DHFA 1VJ3A 3GHWA 3K47A 2W9SA 3NXYA 3IA4A 4H98A 3K2HA 4X5GA 3EELA 4X5HA 3NXTA 4P68A 3GHVA 3S3VA 3CLBA 3JVXA 1DR7A 2LF1A 1RX5A 1DRBA 4M6JA 4NX6A 1AOEA 2FZIA 3SQYX 4KJJA 1RX8A 3OCHA 4ECKA 3SA2A 1DG7A 3UM5A 1RG7A 3QGTA 4G8ZX 1OHJA 2BLBA 3EX8A 4ELGA 4P66A 3HJ3A 1DDSA 4KLXA 4RGCA 1BOZA 5HT5A 3F0XX 1IA1A 1DR6A 1M79A 3FQ0A 1U70A 4DFRA 3NXOA 3QFXA 3NRRA 3RO9A 4M7VA 2P4GA 4LAEX 4I13A 3DATA 3TQ8A 3M08A 1J3KA 3NZAX 3NZ6X 3F0QX 3IX9A 3QLRA 4QLFA 5HI6A 3KY8A 4X5IA 1DDRA 5HSRA 3NZBX 2C2SA 3INVA 1KMSA 3SRSX 2CD2A 3IRNA 4H95A 3CL9A 1RA9A 4H96A 4DPHA 1PD8A 2D0KA 3CD2A 3DRCA 4KEBA 1DYJA 4XT6A 4HOEA 4M6KA 2INQA 4KY8A 1DHFA 1IA4A 1DR1A 1M78A 4PDJA 3FYVX 3SRQX 4KNEA 4KD7A 3S9UA 1DAJA 3DAUA 4OSGA 2B3ZA 4PSTA 3NXXA 3EEKA 4IXFX 3SRRX 3NZCX 4KBNA 3K74A 1DHIA 2ANQA 2CIGA 3DG8A 1ZDRA 5JG0X 1RH3A 3JWFA 1RX6A 1KLKA 4PSYA 2ZZAA 3EEJA 2ITHA 4XE6X 4XT4A 4XT7A 3VCOA 1U72A 1MVTA 4CD2A 5ECCA 1DREA 4PSSA
chains in the Genus database with same CATH superfamily
4X5FA 1S3UA 1RB3A 2XW7A 4TU5X 3QLYA 3F0VX 3FRBX 3OAFA 5HQZA 1CD2A 1DRAA 2W3MA 2W3WA 4Q0EA 4KJKA 2BLAA 4KY4A 3Q1HA 3TD8A 2AZNA 3ROAA 3NXVA 2W3AA 4QI9A 1DR2A 3F8YA 3F0UX 2W9GA 3F91A 1RA8A 1DISA 3KGYA 4LAGX 3NZDA 3FL8A 4Q67A 1U71A 4Q6AA 1RX2A 3F0BX 3GYFA 4DP3A 1PDBA 3IROA 3SAIA 1DR5A 3EIGA 5HSUA 3FREX 4KFJA 1M7AA 4H97A 5U27A 2JYBA 5HPBA 2DRCA 3QLWA 1DYRA 5FDAA 3FY8X 1RB2A 3QL3A 3JWKA 2BL9A 2C2TA 1DLRA 4HA7A 1IA2A 1DRFA 3SGYA 4ELHA 3D84X 1RD7A 3ZPGA 1HFRA 4M6LA 3FL9A 3QYOA 3NZ9X 4EILA 3L3RA 4QHVA 3F0SX 3FQFA 1HFQA 3FQZA 4NX7A 2ANOA 4EIZA 3FS6A 4OR7A 4PTHA 4HA9A 1RA3A 3E0BA 1AI9A 3FQOA 4LAHX 4XT8A 3LG4A 3FQCA 4G3MA 5JA3A 3FQVA 3NXRA 4GH8A 3TQBA 4KYAA 2QK8A 8DFRA 4DDRA 4PTJA 1HFPA 3TQ9A 4FHBA 5HF0X 1LUDA 1QZFA 3SRUX 1J3JA 1JOLA 4IXED 3GI2A 3CSEA 3SH2A 3SRWX 4P3RA 3DL5A 2W3VA 4FGGA 1DG5A 2HXVA 3DFRA 3R33A 4KJLA 4IXGX 1OHKA 3FRDX 1S3WA 2W9TA 3FRAX 1TDRA 3FYWX 3QG2A 1RX1A 1E26A 3JTWA 5U26A 4KAKA 4QLEA 3QYLA 1LY4A 4G95A 3FRFX 3IA5A 4M7UA 1JUVA 2FZJA 1PD9A 3DGAA 1BZFA 1DR4A 2HQPA 3N0HA 3QLXA 5E8QA 3RG9A 1RX4A 2W3BA 4I1NA 1KMVA 2H2QA 4LEKX 4EIGA 1DIUA 3S7AA 5DXVA 1RA1A 3I8AX 2OBCA 1MVSA 3KJSA 4Q0DA 2BLCA 1DG8A 3QL0A 1DLSA 2GD9A 1SEJA 1CZ3A 1DR3A 5HF2X 1DHJA 1IA3A 5EAJA 3I3RA 4DPDA 3EEMA 2HM9A 3M09A 1RC4A 2O7PA 3JW5A 1JOMA 4ELBA 3IRMA 2FZHA 1DYIA 2G6VA 4M2XA 1S3YA 3F8ZA 4HOGA 2D5NA 4ELFA 5CCCA 5HVBA 1J3IA 1RF7A 1RX9A 1S3VA 3JSUA 2W9HA 4XT5A 3FY9X 5HT4A 5CC9A 1VDRA 3NU0A 3K45A 3QLZA 3SA1A 3KFYA 3DL6A 3KJRA 1DF7A 4QJZD 3UM6A 6DFRA 2KGKA 4KM0A 4QJCA 7DFRA 3ZPCA 4X5JA 4HOFA 1DRHA 1RA2A 4FGHA 3JWMA 5HUIA 3GHCA 5ECXA 3NTZA 1AO8A 3JWCA 4XRBA 5DFRA 1RE7A 1YHOA 3JW3A 3D80A 4KM2A 4P3QA 3QLSA 3HBBA 1LY3A 3TQAA 4QLGA 1RX7A 1D1GA 4XECX 2L28A 4KL9A 3SR5X 2OIPA 4EJ1A 3UM8A 5HQYA 4ELEA 5HVEA 1DYHA 1RX3A 2DHFA 1VJ3A 3GHWA 3K47A 2W9SA 3NXYA 3IA4A 4H98A 3K2HA 4X5GA 3EELA 4X5HA 3NXTA 4P68A 3GHVA 3S3VA 3CLBA 3JVXA 1DR7A 2LF1A 1RX5A 1DRBA 4M6JA 4NX6A 1AOEA 2FZIA 3SQYX 4KJJA 1RX8A 3OCHA 4ECKA 3SA2A 1DG7A 3UM5A 1RG7A 3QGTA 4G8ZX 1OHJA 2BLBA 3EX8A 4ELGA 4P66A 3HJ3A 1DDSA 4KLXA 4RGCA 1BOZA 5HT5A 3F0XX 1IA1A 1DR6A 1M79A 3FQ0A 1U70A 4DFRA 3NXOA 3QFXA 3NRRA 3RO9A 4M7VA 2P4GA 4LAEX 4I13A 3DATA 3TQ8A 3M08A 1J3KA 3NZAX 3NZ6X 3F0QX 3IX9A 3QLRA 4QLFA 5HI6A 3KY8A 4X5IA 1DDRA 5HSRA 3NZBX 2C2SA 3INVA 1KMSA 3SRSX 2CD2A 3IRNA 4H95A 3CL9A 1RA9A 4H96A 4DPHA 1PD8A 2D0KA 3CD2A 3DRCA 4KEBA 1DYJA 4XT6A 4HOEA 4M6KA 2INQA 4KY8A 1DHFA 1IA4A 1DR1A 1M78A 4PDJA 3FYVX 3SRQX 4KNEA 4KD7A 3S9UA 1DAJA 3DAUA 4OSGA 2B3ZA 4PSTA 3NXXA 3EEKA 4IXFX 3SRRX 3NZCX 4KBNA 3K74A 1DHIA 2ANQA 2CIGA 3DG8A 1ZDRA 5JG0X 1RH3A 3JWFA 1RX6A 1KLKA 4PSYA 2ZZAA 3EEJA 2ITHA 4XE6X 4XT4A 4XT7A 3VCOA 1U72A 1MVTA 4CD2A 5ECCA 1DREA 4PSSA
chains in the Genus database with same CATH topology
4X5FA 1S3UA 1RB3A 2XW7A 4TU5X 3QLYA 3F0VX 3FRBX 3OAFA 5HQZA 1CD2A 1DRAA 2W3MA 2W3WA 4Q0EA 4KJKA 2BLAA 4KY4A 3Q1HA 3TD8A 2AZNA 3ROAA 3NXVA 2W3AA 4QI9A 1DR2A 3F8YA 3F0UX 2W9GA 3F91A 1RA8A 1DISA 3KGYA 4LAGX 3NZDA 3FL8A 4Q67A 1U71A 4Q6AA 1RX2A 3F0BX 3GYFA 4DP3A 1PDBA 3IROA 3SAIA 1DR5A 3EIGA 5HSUA 3FREX 4KFJA 1M7AA 4H97A 5U27A 2JYBA 5HPBA 2DRCA 3QLWA 1DYRA 5FDAA 3FY8X 1RB2A 3QL3A 3JWKA 2BL9A 2C2TA 1DLRA 4HA7A 1IA2A 1DRFA 3SGYA 4ELHA 3D84X 1RD7A 3ZPGA 1HFRA 4M6LA 3FL9A 3QYOA 3NZ9X 4EILA 3L3RA 4QHVA 3F0SX 3FQFA 1HFQA 3FQZA 4NX7A 2ANOA 4EIZA 3FS6A 4OR7A 4PTHA 4HA9A 1RA3A 3E0BA 1AI9A 3FQOA 4LAHX 4XT8A 3LG4A 3FQCA 4G3MA 5JA3A 3FQVA 3NXRA 4GH8A 3TQBA 4KYAA 2QK8A 8DFRA 4DDRA 4PTJA 1HFPA 3TQ9A 4FHBA 5HF0X 1LUDA 1QZFA 3SRUX 1J3JA 1JOLA 4IXED 3GI2A 3CSEA 3SH2A 3SRWX 4P3RA 3DL5A 2W3VA 4FGGA 1DG5A 2HXVA 3DFRA 3R33A 4KJLA 4IXGX 1OHKA 3FRDX 1S3WA 2W9TA 3FRAX 1TDRA 3FYWX 3QG2A 1RX1A 1E26A 3JTWA 5U26A 4KAKA 4QLEA 3QYLA 1LY4A 4G95A 3FRFX 3IA5A 4M7UA 1JUVA 2FZJA 1PD9A 3DGAA 1BZFA 1DR4A 2HQPA 3N0HA 3QLXA 5E8QA 3RG9A 1RX4A 2W3BA 4I1NA 1KMVA 2H2QA 4LEKX 4EIGA 1DIUA 3S7AA 5DXVA 1RA1A 3I8AX 2OBCA 1MVSA 3KJSA 4Q0DA 2BLCA 1DG8A 3QL0A 1DLSA 2GD9A 1SEJA 1CZ3A 1DR3A 5HF2X 1DHJA 1IA3A 5EAJA 3I3RA 4DPDA 3EEMA 2HM9A 3M09A 1RC4A 2O7PA 3JW5A 1JOMA 4ELBA 3IRMA 2FZHA 1DYIA 2G6VA 4M2XA 1S3YA 3F8ZA 4HOGA 2D5NA 4ELFA 5CCCA 5HVBA 1J3IA 1RF7A 1RX9A 1S3VA 3JSUA 2W9HA 4XT5A 3FY9X 5HT4A 5CC9A 1VDRA 3NU0A 3K45A 3QLZA 3SA1A 3KFYA 3DL6A 3KJRA 1DF7A 4QJZD 3UM6A 6DFRA 2KGKA 4KM0A 4QJCA 7DFRA 3ZPCA 4X5JA 4HOFA 1DRHA 1RA2A 4FGHA 3JWMA 5HUIA 3GHCA 5ECXA 3NTZA 1AO8A 3JWCA 4XRBA 5DFRA 1RE7A 1YHOA 3JW3A 3D80A 4KM2A 4P3QA 3QLSA 3HBBA 1LY3A 3TQAA 4QLGA 1RX7A 1D1GA 4XECX 2L28A 4KL9A 3SR5X 2OIPA 4EJ1A 3UM8A 5HQYA 4ELEA 5HVEA 1DYHA 1RX3A 2DHFA 1VJ3A 3GHWA 3K47A 2W9SA 3NXYA 3IA4A 4H98A 3K2HA 4X5GA 3EELA 4X5HA 3NXTA 4P68A 3GHVA 3S3VA 3CLBA 3JVXA 1DR7A 2LF1A 1RX5A 1DRBA 4M6JA 4NX6A 1AOEA 2FZIA 3SQYX 4KJJA 1RX8A 3OCHA 4ECKA 3SA2A 1DG7A 3UM5A 1RG7A 3QGTA 4G8ZX 1OHJA 2BLBA 3EX8A 4ELGA 4P66A 3HJ3A 1DDSA 4KLXA 4RGCA 1BOZA 5HT5A 3F0XX 1IA1A 1DR6A 1M79A 3FQ0A 1U70A 4DFRA 3NXOA 3QFXA 3NRRA 3RO9A 4M7VA 2P4GA 4LAEX 4I13A 3DATA 3TQ8A 3M08A 1J3KA 3NZAX 3NZ6X 3F0QX 3IX9A 3QLRA 4QLFA 5HI6A 3KY8A 4X5IA 1DDRA 5HSRA 3NZBX 2C2SA 3INVA 1KMSA 3SRSX 2CD2A 3IRNA 4H95A 3CL9A 1RA9A 4H96A 4DPHA 1PD8A 2D0KA 3CD2A 3DRCA 4KEBA 1DYJA 4XT6A 4HOEA 4M6KA 2INQA 4KY8A 1DHFA 1IA4A 1DR1A 1M78A 4PDJA 3FYVX 3SRQX 4KNEA 4KD7A 3S9UA 1DAJA 3DAUA 4OSGA 2B3ZA 4PSTA 3NXXA 3EEKA 4IXFX 3SRRX 3NZCX 4KBNA 3K74A 1DHIA 2ANQA 2CIGA 3DG8A 1ZDRA 5JG0X 1RH3A 3JWFA 1RX6A 1KLKA 4PSYA 2ZZAA 3EEJA 2ITHA 4XE6X 4XT4A 4XT7A 3VCOA 1U72A 1MVTA 4CD2A 5ECCA 1DREA 4PSSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X5F A;  1S3U A;  1RB3 A;  2XW7 A;  4TU5 X;  3QLY A;  3F0V X;  3FRB X;  3OAF A;  5HQZ A;  1CD2 A;  1DRA A;  2W3M A;  2W3W A;  4Q0E A;  4KJK A;  2BLA A;  4KY4 A;  3Q1H A;  3TD8 A;  2AZN A;  3ROA A;  3NXV A;  2W3A A;  4QI9 A;  1DR2 A;  3F8Y A;  3F0U X;  2W9G A;  3F91 A;  1RA8 A;  1DIS A;  3KGY A;  4LAG X;  3NZD A;  3FL8 A;  4Q67 A;  1U71 A;  4Q6A A;  1RX2 A;  3F0B X;  3GYF A;  4DP3 A;  1PDB A;  3IRO A;  3SAI A;  1DR5 A;  3EIG A;  5HSU A;  3FRE X;  4KFJ A;  1M7A A;  4H97 A;  5U27 A;  2JYB A;  5HPB A;  2DRC A;  3QLW A;  1DYR A;  5FDA A;  3FY8 X;  1RB2 A;  3QL3 A;  3JWK A;  2BL9 A;  2C2T A;  1DLR A;  4HA7 A;  1IA2 A;  1DRF A;  3SGY A;  4ELH A;  3D84 X;  1RD7 A;  3ZPG A;  1HFR A;  4M6L A;  3FL9 A;  3QYO A;  3NZ9 X;  4EIL A;  3L3R A;  4QHV A;  3F0S X;  3FQF A;  1HFQ A;  3FQZ A;  4NX7 A;  2ANO A;  4EIZ A;  3FS6 A;  4OR7 A;  4PTH A;  4HA9 A;  1RA3 A;  3E0B A;  1AI9 A;  3FQO A;  4LAH X;  4XT8 A;  3LG4 A;  3FQC A;  4G3M A;  5JA3 A;  3FQV A;  3NXR A;  4GH8 A;  3TQB A;  4KYA A;  2QK8 A;  8DFR A;  4DDR A;  4PTJ A;  1HFP A;  3TQ9 A;  4FHB A;  5HF0 X;  1LUD A;  1QZF A;  3SRU X;  1J3J A;  1JOL A;  4IXE D;  3GI2 A;  3CSE A;  3SH2 A;  3SRW X;  4P3R A;  3DL5 A;  2W3V A;  4FGG A;  1DG5 A;  2HXV A;  3DFR A;  3R33 A;  4KJL A;  4IXG X;  1OHK A;  3FRD X;  1S3W A;  2W9T A;  3FRA X;  1TDR A;  3FYW X;  3QG2 A;  1RX1 A;  1E26 A;  3JTW A;  5U26 A;  4KAK A;  4QLE A;  3QYL A;  1LY4 A;  4G95 A;  3FRF X;  3IA5 A;  4M7U A;  1JUV A;  2FZJ A;  1PD9 A;  3DGA A;  1BZF A;  1DR4 A;  2HQP A;  3N0H A;  3QLX A;  5E8Q A;  3RG9 A;  1RX4 A;  2W3B A;  4I1N A;  1KMV A;  2H2Q A;  4LEK X;  4EIG A;  1DIU A;  3S7A A;  5DXV A;  1RA1 A;  3I8A X;  2OBC A;  1MVS A;  3KJS A;  4Q0D A;  2BLC A;  1DG8 A;  3QL0 A;  1DLS A;  2GD9 A;  1SEJ A;  1CZ3 A;  1DR3 A;  5HF2 X;  1DHJ A;  1IA3 A;  5EAJ A;  3I3R A;  4DPD A;  3EEM A;  2HM9 A;  3M09 A;  1RC4 A;  2O7P A;  3JW5 A;  1JOM A;  4ELB A;  3IRM A;  2FZH A;  1DYI A;  2G6V A;  4M2X A;  1S3Y A;  3F8Z A;  4HOG A;  2D5N A;  4ELF A;  5CCC A;  5HVB A;  1J3I A;  1RF7 A;  1RX9 A;  1S3V A;  3JSU A;  2W9H A;  4XT5 A;  3FY9 X;  5HT4 A;  5CC9 A;  1VDR A;  3NU0 A;  3K45 A;  3QLZ A;  3SA1 A;  3KFY A;  3DL6 A;  3KJR A;  1DF7 A;  4QJZ D;  3UM6 A;  6DFR A;  2KGK A;  4KM0 A;  4QJC A;  7DFR A;  3ZPC A;  4X5J A;  4HOF A;  1DRH A;  1RA2 A;  4FGH A;  3JWM A;  5HUI A;  3GHC A;  5ECX A;  3NTZ A;  1AO8 A;  3JWC A;  4XRB A;  5DFR A;  1RE7 A;  1YHO A;  3JW3 A;  3D80 A;  4KM2 A;  4P3Q A;  3QLS A;  3HBB A;  1LY3 A;  3TQA A;  4QLG A;  1RX7 A;  1D1G A;  4XEC X;  2L28 A;  4KL9 A;  3SR5 X;  2OIP A;  4EJ1 A;  3UM8 A;  5HQY A;  4ELE A;  5HVE A;  1DYH A;  1RX3 A;  2DHF A;  1VJ3 A;  3GHW A;  3K47 A;  2W9S A;  3NXY A;  3IA4 A;  4H98 A;  3K2H A;  4X5G A;  3EEL A;  4X5H A;  3NXT A;  4P68 A;  3GHV A;  3S3V A;  3CLB A;  3JVX A;  1DR7 A;  2LF1 A;  1RX5 A;  1DRB A;  4M6J A;  4NX6 A;  1AOE A;  2FZI A;  3SQY X;  4KJJ A;  1RX8 A;  3OCH A;  4ECK A;  3SA2 A;  1DG7 A;  3UM5 A;  1RG7 A;  3QGT A;  4G8Z X;  1OHJ A;  2BLB A;  3EX8 A;  4ELG A;  4P66 A;  3HJ3 A;  1DDS A;  4KLX A;  4RGC A;  1BOZ A;  5HT5 A;  3F0X X;  1IA1 A;  1DR6 A;  1M79 A;  3FQ0 A;  1U70 A;  4DFR A;  3NXO A;  3QFX A;  3NRR A;  3RO9 A;  4M7V A;  2P4G A;  4LAE X;  4I13 A;  3DAT A;  3TQ8 A;  3M08 A;  1J3K A;  3NZA X;  3NZ6 X;  3F0Q X;  3IX9 A;  3QLR A;  4QLF A;  5HI6 A;  3KY8 A;  4X5I A;  1DDR A;  5HSR A;  3NZB X;  2C2S A;  3INV A;  1KMS A;  3SRS X;  2CD2 A;  3IRN A;  4H95 A;  3CL9 A;  1RA9 A;  4H96 A;  4DPH A;  1PD8 A;  2D0K A;  3CD2 A;  3DRC A;  4KEB A;  1DYJ A;  4XT6 A;  4HOE A;  4M6K A;  2INQ A;  4KY8 A;  1DHF A;  1IA4 A;  1DR1 A;  1M78 A;  4PDJ A;  3FYV X;  3SRQ X;  4KNE A;  4KD7 A;  3S9U A;  1DAJ A;  3DAU A;  4OSG A;  2B3Z A;  4PST A;  3NXX A;  3EEK A;  4IXF X;  3SRR X;  3NZC X;  4KBN A;  3K74 A;  1DHI A;  2ANQ A;  2CIG A;  3DG8 A;  1ZDR A;  5JG0 X;  1RH3 A;  3JWF A;  1RX6 A;  1KLK A;  4PSY A;  2ZZA A;  3EEJ A;  2ITH A;  4XE6 X;  4XT4 A;  4XT7 A;  3VCO A;  1U72 A;  1MVT A;  4CD2 A;  5ECC A;  1DRE A;  4PSS A; 
#chains in the Genus database with same CATH topology
 4X5F A;  1S3U A;  1RB3 A;  2XW7 A;  4TU5 X;  3QLY A;  3F0V X;  3FRB X;  3OAF A;  5HQZ A;  1CD2 A;  1DRA A;  2W3M A;  2W3W A;  4Q0E A;  4KJK A;  2BLA A;  4KY4 A;  3Q1H A;  3TD8 A;  2AZN A;  3ROA A;  3NXV A;  2W3A A;  4QI9 A;  1DR2 A;  3F8Y A;  3F0U X;  2W9G A;  3F91 A;  1RA8 A;  1DIS A;  3KGY A;  4LAG X;  3NZD A;  3FL8 A;  4Q67 A;  1U71 A;  4Q6A A;  1RX2 A;  3F0B X;  3GYF A;  4DP3 A;  1PDB A;  3IRO A;  3SAI A;  1DR5 A;  3EIG A;  5HSU A;  3FRE X;  4KFJ A;  1M7A A;  4H97 A;  5U27 A;  2JYB A;  5HPB A;  2DRC A;  3QLW A;  1DYR A;  5FDA A;  3FY8 X;  1RB2 A;  3QL3 A;  3JWK A;  2BL9 A;  2C2T A;  1DLR A;  4HA7 A;  1IA2 A;  1DRF A;  3SGY A;  4ELH A;  3D84 X;  1RD7 A;  3ZPG A;  1HFR A;  4M6L A;  3FL9 A;  3QYO A;  3NZ9 X;  4EIL A;  3L3R A;  4QHV A;  3F0S X;  3FQF A;  1HFQ A;  3FQZ A;  4NX7 A;  2ANO A;  4EIZ A;  3FS6 A;  4OR7 A;  4PTH A;  4HA9 A;  1RA3 A;  3E0B A;  1AI9 A;  3FQO A;  4LAH X;  4XT8 A;  3LG4 A;  3FQC A;  4G3M A;  5JA3 A;  3FQV A;  3NXR A;  4GH8 A;  3TQB A;  4KYA A;  2QK8 A;  8DFR A;  4DDR A;  4PTJ A;  1HFP A;  3TQ9 A;  4FHB A;  5HF0 X;  1LUD A;  1QZF A;  3SRU X;  1J3J A;  1JOL A;  4IXE D;  3GI2 A;  3CSE A;  3SH2 A;  3SRW X;  4P3R A;  3DL5 A;  2W3V A;  4FGG A;  1DG5 A;  2HXV A;  3DFR A;  3R33 A;  4KJL A;  4IXG X;  1OHK A;  3FRD X;  1S3W A;  2W9T A;  3FRA X;  1TDR A;  3FYW X;  3QG2 A;  1RX1 A;  1E26 A;  3JTW A;  5U26 A;  4KAK A;  4QLE A;  3QYL A;  1LY4 A;  4G95 A;  3FRF X;  3IA5 A;  4M7U A;  1JUV A;  2FZJ A;  1PD9 A;  3DGA A;  1BZF A;  1DR4 A;  2HQP A;  3N0H A;  3QLX A;  5E8Q A;  3RG9 A;  1RX4 A;  2W3B A;  4I1N A;  1KMV A;  2H2Q A;  4LEK X;  4EIG A;  1DIU A;  3S7A A;  5DXV A;  1RA1 A;  3I8A X;  2OBC A;  1MVS A;  3KJS A;  4Q0D A;  2BLC A;  1DG8 A;  3QL0 A;  1DLS A;  2GD9 A;  1SEJ A;  1CZ3 A;  1DR3 A;  5HF2 X;  1DHJ A;  1IA3 A;  5EAJ A;  3I3R A;  4DPD A;  3EEM A;  2HM9 A;  3M09 A;  1RC4 A;  2O7P A;  3JW5 A;  1JOM A;  4ELB A;  3IRM A;  2FZH A;  1DYI A;  2G6V A;  4M2X A;  1S3Y A;  3F8Z A;  4HOG A;  2D5N A;  4ELF A;  5CCC A;  5HVB A;  1J3I A;  1RF7 A;  1RX9 A;  1S3V A;  3JSU A;  2W9H A;  4XT5 A;  3FY9 X;  5HT4 A;  5CC9 A;  1VDR A;  3NU0 A;  3K45 A;  3QLZ A;  3SA1 A;  3KFY A;  3DL6 A;  3KJR A;  1DF7 A;  4QJZ D;  3UM6 A;  6DFR A;  2KGK A;  4KM0 A;  4QJC A;  7DFR A;  3ZPC A;  4X5J A;  4HOF A;  1DRH A;  1RA2 A;  4FGH A;  3JWM A;  5HUI A;  3GHC A;  5ECX A;  3NTZ A;  1AO8 A;  3JWC A;  4XRB A;  5DFR A;  1RE7 A;  1YHO A;  3JW3 A;  3D80 A;  4KM2 A;  4P3Q A;  3QLS A;  3HBB A;  1LY3 A;  3TQA A;  4QLG A;  1RX7 A;  1D1G A;  4XEC X;  2L28 A;  4KL9 A;  3SR5 X;  2OIP A;  4EJ1 A;  3UM8 A;  5HQY A;  4ELE A;  5HVE A;  1DYH A;  1RX3 A;  2DHF A;  1VJ3 A;  3GHW A;  3K47 A;  2W9S A;  3NXY A;  3IA4 A;  4H98 A;  3K2H A;  4X5G A;  3EEL A;  4X5H A;  3NXT A;  4P68 A;  3GHV A;  3S3V A;  3CLB A;  3JVX A;  1DR7 A;  2LF1 A;  1RX5 A;  1DRB A;  4M6J A;  4NX6 A;  1AOE A;  2FZI A;  3SQY X;  4KJJ A;  1RX8 A;  3OCH A;  4ECK A;  3SA2 A;  1DG7 A;  3UM5 A;  1RG7 A;  3QGT A;  4G8Z X;  1OHJ A;  2BLB A;  3EX8 A;  4ELG A;  4P66 A;  3HJ3 A;  1DDS A;  4KLX A;  4RGC A;  1BOZ A;  5HT5 A;  3F0X X;  1IA1 A;  1DR6 A;  1M79 A;  3FQ0 A;  1U70 A;  4DFR A;  3NXO A;  3QFX A;  3NRR A;  3RO9 A;  4M7V A;  2P4G A;  4LAE X;  4I13 A;  3DAT A;  3TQ8 A;  3M08 A;  1J3K A;  3NZA X;  3NZ6 X;  3F0Q X;  3IX9 A;  3QLR A;  4QLF A;  5HI6 A;  3KY8 A;  4X5I A;  1DDR A;  5HSR A;  3NZB X;  2C2S A;  3INV A;  1KMS A;  3SRS X;  2CD2 A;  3IRN A;  4H95 A;  3CL9 A;  1RA9 A;  4H96 A;  4DPH A;  1PD8 A;  2D0K A;  3CD2 A;  3DRC A;  4KEB A;  1DYJ A;  4XT6 A;  4HOE A;  4M6K A;  2INQ A;  4KY8 A;  1DHF A;  1IA4 A;  1DR1 A;  1M78 A;  4PDJ A;  3FYV X;  3SRQ X;  4KNE A;  4KD7 A;  3S9U A;  1DAJ A;  3DAU A;  4OSG A;  2B3Z A;  4PST A;  3NXX A;  3EEK A;  4IXF X;  3SRR X;  3NZC X;  4KBN A;  3K74 A;  1DHI A;  2ANQ A;  2CIG A;  3DG8 A;  1ZDR A;  5JG0 X;  1RH3 A;  3JWF A;  1RX6 A;  1KLK A;  4PSY A;  2ZZA A;  3EEJ A;  2ITH A;  4XE6 X;  4XT4 A;  4XT7 A;  3VCO A;  1U72 A;  1MVT A;  4CD2 A;  5ECC A;  1DRE A;  4PSS A; 
#chains in the Genus database with same CATH homology
 4X5F A;  1S3U A;  1RB3 A;  2XW7 A;  4TU5 X;  3QLY A;  3F0V X;  3FRB X;  3OAF A;  5HQZ A;  1CD2 A;  1DRA A;  2W3M A;  2W3W A;  4Q0E A;  4KJK A;  2BLA A;  4KY4 A;  3Q1H A;  3TD8 A;  2AZN A;  3ROA A;  3NXV A;  2W3A A;  4QI9 A;  1DR2 A;  3F8Y A;  3F0U X;  2W9G A;  3F91 A;  1RA8 A;  1DIS A;  3KGY A;  4LAG X;  3NZD A;  3FL8 A;  4Q67 A;  1U71 A;  4Q6A A;  1RX2 A;  3F0B X;  3GYF A;  4DP3 A;  1PDB A;  3IRO A;  3SAI A;  1DR5 A;  3EIG A;  5HSU A;  3FRE X;  4KFJ A;  1M7A A;  4H97 A;  5U27 A;  2JYB A;  5HPB A;  2DRC A;  3QLW A;  1DYR A;  5FDA A;  3FY8 X;  1RB2 A;  3QL3 A;  3JWK A;  2BL9 A;  2C2T A;  1DLR A;  4HA7 A;  1IA2 A;  1DRF A;  3SGY A;  4ELH A;  3D84 X;  1RD7 A;  3ZPG A;  1HFR A;  4M6L A;  3FL9 A;  3QYO A;  3NZ9 X;  4EIL A;  3L3R A;  4QHV A;  3F0S X;  3FQF A;  1HFQ A;  3FQZ A;  4NX7 A;  2ANO A;  4EIZ A;  3FS6 A;  4OR7 A;  4PTH A;  4HA9 A;  1RA3 A;  3E0B A;  1AI9 A;  3FQO A;  4LAH X;  4XT8 A;  3LG4 A;  3FQC A;  4G3M A;  5JA3 A;  3FQV A;  3NXR A;  4GH8 A;  3TQB A;  4KYA A;  2QK8 A;  8DFR A;  4DDR A;  4PTJ A;  1HFP A;  3TQ9 A;  4FHB A;  5HF0 X;  1LUD A;  1QZF A;  3SRU X;  1J3J A;  1JOL A;  4IXE D;  3GI2 A;  3CSE A;  3SH2 A;  3SRW X;  4P3R A;  3DL5 A;  2W3V A;  4FGG A;  1DG5 A;  2HXV A;  3DFR A;  3R33 A;  4KJL A;  4IXG X;  1OHK A;  3FRD X;  1S3W A;  2W9T A;  3FRA X;  1TDR A;  3FYW X;  3QG2 A;  1RX1 A;  1E26 A;  3JTW A;  5U26 A;  4KAK A;  4QLE A;  3QYL A;  1LY4 A;  4G95 A;  3FRF X;  3IA5 A;  4M7U A;  1JUV A;  2FZJ A;  1PD9 A;  3DGA A;  1BZF A;  1DR4 A;  2HQP A;  3N0H A;  3QLX A;  5E8Q A;  3RG9 A;  1RX4 A;  2W3B A;  4I1N A;  1KMV A;  2H2Q A;  4LEK X;  4EIG A;  1DIU A;  3S7A A;  5DXV A;  1RA1 A;  3I8A X;  2OBC A;  1MVS A;  3KJS A;  4Q0D A;  2BLC A;  1DG8 A;  3QL0 A;  1DLS A;  2GD9 A;  1SEJ A;  1CZ3 A;  1DR3 A;  5HF2 X;  1DHJ A;  1IA3 A;  5EAJ A;  3I3R A;  4DPD A;  3EEM A;  2HM9 A;  3M09 A;  1RC4 A;  2O7P A;  3JW5 A;  1JOM A;  4ELB A;  3IRM A;  2FZH A;  1DYI A;  2G6V A;  4M2X A;  1S3Y A;  3F8Z A;  4HOG A;  2D5N A;  4ELF A;  5CCC A;  5HVB A;  1J3I A;  1RF7 A;  1RX9 A;  1S3V A;  3JSU A;  2W9H A;  4XT5 A;  3FY9 X;  5HT4 A;  5CC9 A;  1VDR A;  3NU0 A;  3K45 A;  3QLZ A;  3SA1 A;  3KFY A;  3DL6 A;  3KJR A;  1DF7 A;  4QJZ D;  3UM6 A;  6DFR A;  2KGK A;  4KM0 A;  4QJC A;  7DFR A;  3ZPC A;  4X5J A;  4HOF A;  1DRH A;  1RA2 A;  4FGH A;  3JWM A;  5HUI A;  3GHC A;  5ECX A;  3NTZ A;  1AO8 A;  3JWC A;  4XRB A;  5DFR A;  1RE7 A;  1YHO A;  3JW3 A;  3D80 A;  4KM2 A;  4P3Q A;  3QLS A;  3HBB A;  1LY3 A;  3TQA A;  4QLG A;  1RX7 A;  1D1G A;  4XEC X;  2L28 A;  4KL9 A;  3SR5 X;  2OIP A;  4EJ1 A;  3UM8 A;  5HQY A;  4ELE A;  5HVE A;  1DYH A;  1RX3 A;  2DHF A;  1VJ3 A;  3GHW A;  3K47 A;  2W9S A;  3NXY A;  3IA4 A;  4H98 A;  3K2H A;  4X5G A;  3EEL A;  4X5H A;  3NXT A;  4P68 A;  3GHV A;  3S3V A;  3CLB A;  3JVX A;  1DR7 A;  2LF1 A;  1RX5 A;  1DRB A;  4M6J A;  4NX6 A;  1AOE A;  2FZI A;  3SQY X;  4KJJ A;  1RX8 A;  3OCH A;  4ECK A;  3SA2 A;  1DG7 A;  3UM5 A;  1RG7 A;  3QGT A;  4G8Z X;  1OHJ A;  2BLB A;  3EX8 A;  4ELG A;  4P66 A;  3HJ3 A;  1DDS A;  4KLX A;  4RGC A;  1BOZ A;  5HT5 A;  3F0X X;  1IA1 A;  1DR6 A;  1M79 A;  3FQ0 A;  1U70 A;  4DFR A;  3NXO A;  3QFX A;  3NRR A;  3RO9 A;  4M7V A;  2P4G A;  4LAE X;  4I13 A;  3DAT A;  3TQ8 A;  3M08 A;  1J3K A;  3NZA X;  3NZ6 X;  3F0Q X;  3IX9 A;  3QLR A;  4QLF A;  5HI6 A;  3KY8 A;  4X5I A;  1DDR A;  5HSR A;  3NZB X;  2C2S A;  3INV A;  1KMS A;  3SRS X;  2CD2 A;  3IRN A;  4H95 A;  3CL9 A;  1RA9 A;  4H96 A;  4DPH A;  1PD8 A;  2D0K A;  3CD2 A;  3DRC A;  4KEB A;  1DYJ A;  4XT6 A;  4HOE A;  4M6K A;  2INQ A;  4KY8 A;  1DHF A;  1IA4 A;  1DR1 A;  1M78 A;  4PDJ A;  3FYV X;  3SRQ X;  4KNE A;  4KD7 A;  3S9U A;  1DAJ A;  3DAU A;  4OSG A;  2B3Z A;  4PST A;  3NXX A;  3EEK A;  4IXF X;  3SRR X;  3NZC X;  4KBN A;  3K74 A;  1DHI A;  2ANQ A;  2CIG A;  3DG8 A;  1ZDR A;  5JG0 X;  1RH3 A;  3JWF A;  1RX6 A;  1KLK A;  4PSY A;  2ZZA A;  3EEJ A;  2ITH A;  4XE6 X;  4XT4 A;  4XT7 A;  3VCO A;  1U72 A;  1MVT A;  4CD2 A;  5ECC A;  1DRE A;  4PSS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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