3NXXA

Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro-2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 58
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3nxxA00
2XW7A 1RX8A 4ELGA 1J3IA 3SA2A 4RGCA 3R33A 3IROA 4XECX 3N0HA 6DFRA 4H98A 3QL0A 1JOLA 4XT8A 3TQBA 3KFYA 3NU0A 4XE6X 2P4GA 2LF1A 5HVEA 3F0SX 3F91A 2B3ZA 3QYOA 1DR6A 4PSSA 1RX9A 2DHFA 1SEJA 2ANOA 4HA7A 4M6KA 3HJ3A 3NRRA 1S3VA 2CD2A 3JVXA 1RB3A 5HVBA 3KGYA 4DPHA 3FQFA 1DR5A 3SR5X 2W9SA 4KY8A 1M79A 1DRFA 3E0BA 4QHVA 5DXVA 1HFPA 1RX5A 4P3QA 1DYHA 3GYFA 3CD2A 1DR3A 1OHJA 4X5GA 3SGYA 1DDSA 3FRAX 4HA9A 2INQA 1MVSA 3QLWA 2HM9A 5E8QA 3UM8A 1DHFA 4H96A 2W9HA 1J3JA 3DGAA 4NX7A 3INVA 3FQOA 4LAEX 4KFJA 1RA3A 4QLGA 4G8ZX 3D80A 4H97A 1RD7A 1RX1A 3FL9A 1S3UA 1ZDRA 4KAKA 4Q67A 1DRHA 1DF7A 1RA1A 2ANQA 3RO9A 2BLCA 3JWFA 1DISA 5HF2X 5HF0X 1DRBA 4M6LA 4HOEA 1KMSA 2BLBA 5ECCA 4PSTA 1DG8A 4HOFA 3HBBA 1DG7A 1DR7A 4P3RA 3L3RA 1HFRA 3NZBX 3IX9A 3EX8A 4KEBA 2W9GA 3QLYA 3SRSX 3ZPGA 3NTZA 4EIZA 3SAIA 2C2TA 2GD9A 3K2HA 1DR4A 2W3BA 1MVTA 1DAJA 3DL5A 3FQZA 3JSUA 2D5NA 3FYVX 3NZ9X 5HT4A 1U71A 4HOGA 2HXVA 1RA9A 1S3YA 4OR7A 2HQPA 4XT4A 4M7VA 3NZ6X 3SRRX 3TQAA 1RB2A 1DYJA 3EIGA 3OCHA 4EILA 3CLBA 3FY9X 3SRQX 1DREA 1AI9A 3FQCA 4DPDA 2D0KA 5FDAA 4KLXA 3SH2A 1DRAA 1M78A 4KL9A 4KYAA 3SA1A 3S7AA 2W3VA 4XT5A 3NZCX 3ROAA 3EELA 1OHKA 1LY3A 3JW3A 4QLFA 8DFRA 4XT6A 3IRNA 1BZFA 3FRFX 3QLSA 1RH3A 2DRCA 1PD8A 1RX6A 5ECXA 1E26A 4X5FA 3UM5A 1IA4A 1TDRA 5JG0X 1RX7A 3QGTA 4M2XA 3FL8A 3JWKA 4X5JA 4EIGA 1CD2A 3K74A 4X5HA 4FGHA 4QI9A 2AZNA 3FRDX 3FY8X 1DIUA 3JW5A 4KJKA 1DR1A 4Q6AA 4XT7A 5U26A 4NX6A 1RG7A 3QLZA 3EEMA 4GH8A 1KMVA 5HI6A 3ZPCA 1BOZA 1RE7A 3K45A 4P68A 1CZ3A 4LAHX 5HQYA 4XRBA 3EEJA 3DL6A 2H2QA 4KBNA 1U70A 3QLRA 1RA8A 4DP3A 3EEKA 1J3KA 5HQZA 3DATA 2L28A 3DAUA 1RF7A 3FREX 4CD2A 3OAFA 1RX3A 3GI2A 4TU5X 5HUIA 3IRMA 2W3MA 2W3AA 1JUVA 4PTHA 2FZHA 1AOEA 4IXED 2BLAA 1DR2A 3F0VX 3TQ9A 3NZDA 4DFRA 2FZIA 4KNEA 3JWCA 2C2SA 5CCCA 2OIPA 3NXXA 3Q1HA 5HT5A 3M08A 3NXYA 4M6JA 4Q0EA 5JA3A 3FQVA 5DFRA 4IXGX 4X5IA 5HSUA 4ELFA 4H95A 3VCOA 2ITHA 4DDRA 1JOMA 1M7AA 3JWMA 3JTWA 3NXRA 4KJJA 3S9UA 1LUDA 1U72A 1D1GA 2ZZAA 4ELEA 4IXFX 2OBCA 1DLRA 1RC4A 3I3RA 4FGGA 2CIGA 2QK8A 3QFXA 1KLKA 4PTJA 3F0UX 1S3WA 1DHIA 2W9TA 3DRCA 3LG4A 3K47A 4I13A 1DLSA 3F8YA 1PD9A 3KY8A 1RX2A 5CC9A 2BL9A 3NXVA 3NZAX 5EAJA 3GHVA 3CL9A 1DG5A 7DFRA 3IA5A 3RG9A 3IA4A 3QL3A 3F0XX 4P66A 3SQYX 3QYLA 4QLEA 4M7UA 1DDRA 1IA1A 4PDJA 3TQ8A 3QG2A 4KM2A 4LAGX 4QJCA 4OSGA 2O7PA 5U27A 3KJRA 2G6VA 4LEKX 4G3MA 1YHOA 1LY4A 3I8AX 4ELHA 3TD8A 3M09A 3DG8A 1RA2A 3NXTA 1VJ3A 3SRWX 3F0QX 3GHWA 3S3VA 3KJSA 4ECKA 4G95A 3F0BX 4KY4A 1IA3A 4KD7A 2KGKA 1AO8A 5HSRA 4EJ1A 4Q0DA 1IA2A 5HPBA 2FZJA 4KM0A 3FQ0A 1DHJA 3FS6A 3CSEA 3DFRA 2JYBA 4QJZD 4PSYA 1HFQA 1QZFA 3GHCA 1DYIA 4ELBA 4FHBA 1PDBA 1RX4A 3FRBX 2W3WA 1DYRA 3NXOA 3F8ZA 3FYWX 3D84X 4I1NA 3SRUX 1VDRA 4KJLA 3QLXA 3UM6A
chains in the Genus database with same CATH superfamily
2XW7A 1RX8A 4ELGA 1J3IA 3SA2A 4RGCA 3R33A 3IROA 4XECX 3N0HA 6DFRA 4H98A 3QL0A 1JOLA 4XT8A 3TQBA 3KFYA 3NU0A 4XE6X 2P4GA 2LF1A 5HVEA 3F0SX 3F91A 2B3ZA 3QYOA 1DR6A 4PSSA 1RX9A 2DHFA 1SEJA 2ANOA 4HA7A 4M6KA 3HJ3A 3NRRA 1S3VA 2CD2A 3JVXA 1RB3A 5HVBA 3KGYA 4DPHA 3FQFA 1DR5A 3SR5X 2W9SA 4KY8A 1M79A 1DRFA 3E0BA 4QHVA 5DXVA 1HFPA 1RX5A 4P3QA 1DYHA 3GYFA 3CD2A 1DR3A 1OHJA 4X5GA 3SGYA 1DDSA 3FRAX 4HA9A 2INQA 1MVSA 3QLWA 2HM9A 5E8QA 3UM8A 1DHFA 4H96A 2W9HA 1J3JA 3DGAA 4NX7A 3INVA 3FQOA 4LAEX 4KFJA 1RA3A 4QLGA 4G8ZX 3D80A 4H97A 1RD7A 1RX1A 3FL9A 1S3UA 1ZDRA 4KAKA 4Q67A 1DRHA 1DF7A 1RA1A 2ANQA 3RO9A 2BLCA 3JWFA 1DISA 5HF2X 5HF0X 1DRBA 4M6LA 4HOEA 1KMSA 2BLBA 5ECCA 4PSTA 1DG8A 4HOFA 3HBBA 1DG7A 1DR7A 4P3RA 3L3RA 1HFRA 3NZBX 3IX9A 3EX8A 4KEBA 2W9GA 3QLYA 3SRSX 3ZPGA 3NTZA 4EIZA 3SAIA 2C2TA 2GD9A 3K2HA 1DR4A 2W3BA 1MVTA 1DAJA 3DL5A 3FQZA 3JSUA 2D5NA 3FYVX 3NZ9X 5HT4A 1U71A 4HOGA 2HXVA 1RA9A 1S3YA 4OR7A 2HQPA 4XT4A 4M7VA 3NZ6X 3SRRX 3TQAA 1RB2A 1DYJA 3EIGA 3OCHA 4EILA 3CLBA 3FY9X 3SRQX 1DREA 1AI9A 3FQCA 4DPDA 2D0KA 5FDAA 4KLXA 3SH2A 1DRAA 1M78A 4KL9A 4KYAA 3SA1A 3S7AA 2W3VA 4XT5A 3NZCX 3ROAA 3EELA 1OHKA 1LY3A 3JW3A 4QLFA 8DFRA 4XT6A 3IRNA 1BZFA 3FRFX 3QLSA 1RH3A 2DRCA 1PD8A 1RX6A 5ECXA 1E26A 4X5FA 3UM5A 1IA4A 1TDRA 5JG0X 1RX7A 3QGTA 4M2XA 3FL8A 3JWKA 4X5JA 4EIGA 1CD2A 3K74A 4X5HA 4FGHA 4QI9A 2AZNA 3FRDX 3FY8X 1DIUA 3JW5A 4KJKA 1DR1A 4Q6AA 4XT7A 5U26A 4NX6A 1RG7A 3QLZA 3EEMA 4GH8A 1KMVA 5HI6A 3ZPCA 1BOZA 1RE7A 3K45A 4P68A 1CZ3A 4LAHX 5HQYA 4XRBA 3EEJA 3DL6A 2H2QA 4KBNA 1U70A 3QLRA 1RA8A 4DP3A 3EEKA 1J3KA 5HQZA 3DATA 2L28A 3DAUA 1RF7A 3FREX 4CD2A 3OAFA 1RX3A 3GI2A 4TU5X 5HUIA 3IRMA 2W3MA 2W3AA 1JUVA 4PTHA 2FZHA 1AOEA 4IXED 2BLAA 1DR2A 3F0VX 3TQ9A 3NZDA 4DFRA 2FZIA 4KNEA 3JWCA 2C2SA 5CCCA 2OIPA 3NXXA 3Q1HA 5HT5A 3M08A 3NXYA 4M6JA 4Q0EA 5JA3A 3FQVA 5DFRA 4IXGX 4X5IA 5HSUA 4ELFA 4H95A 3VCOA 2ITHA 4DDRA 1JOMA 1M7AA 3JWMA 3JTWA 3NXRA 4KJJA 3S9UA 1LUDA 1U72A 1D1GA 2ZZAA 4ELEA 4IXFX 2OBCA 1DLRA 1RC4A 3I3RA 4FGGA 2CIGA 2QK8A 3QFXA 1KLKA 4PTJA 3F0UX 1S3WA 1DHIA 2W9TA 3DRCA 3LG4A 3K47A 4I13A 1DLSA 3F8YA 1PD9A 3KY8A 1RX2A 5CC9A 2BL9A 3NXVA 3NZAX 5EAJA 3GHVA 3CL9A 1DG5A 7DFRA 3IA5A 3RG9A 3IA4A 3QL3A 3F0XX 4P66A 3SQYX 3QYLA 4QLEA 4M7UA 1DDRA 1IA1A 4PDJA 3TQ8A 3QG2A 4KM2A 4LAGX 4QJCA 4OSGA 2O7PA 5U27A 3KJRA 2G6VA 4LEKX 4G3MA 1YHOA 1LY4A 3I8AX 4ELHA 3TD8A 3M09A 3DG8A 1RA2A 3NXTA 1VJ3A 3SRWX 3F0QX 3GHWA 3S3VA 3KJSA 4ECKA 4G95A 3F0BX 4KY4A 1IA3A 4KD7A 2KGKA 1AO8A 5HSRA 4EJ1A 4Q0DA 1IA2A 5HPBA 2FZJA 4KM0A 3FQ0A 1DHJA 3FS6A 3CSEA 3DFRA 2JYBA 4QJZD 4PSYA 1HFQA 1QZFA 3GHCA 1DYIA 4ELBA 4FHBA 1PDBA 1RX4A 3FRBX 2W3WA 1DYRA 3NXOA 3F8ZA 3FYWX 3D84X 4I1NA 3SRUX 1VDRA 4KJLA 3QLXA 3UM6A
chains in the Genus database with same CATH topology
2XW7A 1RX8A 4ELGA 1J3IA 3SA2A 4RGCA 3R33A 3IROA 4XECX 3N0HA 6DFRA 4H98A 3QL0A 1JOLA 4XT8A 3TQBA 3KFYA 3NU0A 4XE6X 2P4GA 2LF1A 5HVEA 3F0SX 3F91A 2B3ZA 3QYOA 1DR6A 4PSSA 1RX9A 2DHFA 1SEJA 2ANOA 4HA7A 4M6KA 3HJ3A 3NRRA 1S3VA 2CD2A 3JVXA 1RB3A 5HVBA 3KGYA 4DPHA 3FQFA 1DR5A 3SR5X 2W9SA 4KY8A 1M79A 1DRFA 3E0BA 4QHVA 5DXVA 1HFPA 1RX5A 4P3QA 1DYHA 3GYFA 3CD2A 1DR3A 1OHJA 4X5GA 3SGYA 1DDSA 3FRAX 4HA9A 2INQA 1MVSA 3QLWA 2HM9A 5E8QA 3UM8A 1DHFA 4H96A 2W9HA 1J3JA 3DGAA 4NX7A 3INVA 3FQOA 4LAEX 4KFJA 1RA3A 4QLGA 4G8ZX 3D80A 4H97A 1RD7A 1RX1A 3FL9A 1S3UA 1ZDRA 4KAKA 4Q67A 1DRHA 1DF7A 1RA1A 2ANQA 3RO9A 2BLCA 3JWFA 1DISA 5HF2X 5HF0X 1DRBA 4M6LA 4HOEA 1KMSA 2BLBA 5ECCA 4PSTA 1DG8A 4HOFA 3HBBA 1DG7A 1DR7A 4P3RA 3L3RA 1HFRA 3NZBX 3IX9A 3EX8A 4KEBA 2W9GA 3QLYA 3SRSX 3ZPGA 3NTZA 4EIZA 3SAIA 2C2TA 2GD9A 3K2HA 1DR4A 2W3BA 1MVTA 1DAJA 3DL5A 3FQZA 3JSUA 2D5NA 3FYVX 3NZ9X 5HT4A 1U71A 4HOGA 2HXVA 1RA9A 1S3YA 4OR7A 2HQPA 4XT4A 4M7VA 3NZ6X 3SRRX 3TQAA 1RB2A 1DYJA 3EIGA 3OCHA 4EILA 3CLBA 3FY9X 3SRQX 1DREA 1AI9A 3FQCA 4DPDA 2D0KA 5FDAA 4KLXA 3SH2A 1DRAA 1M78A 4KL9A 4KYAA 3SA1A 3S7AA 2W3VA 4XT5A 3NZCX 3ROAA 3EELA 1OHKA 1LY3A 3JW3A 4QLFA 8DFRA 4XT6A 3IRNA 1BZFA 3FRFX 3QLSA 1RH3A 2DRCA 1PD8A 1RX6A 5ECXA 1E26A 4X5FA 3UM5A 1IA4A 1TDRA 5JG0X 1RX7A 3QGTA 4M2XA 3FL8A 3JWKA 4X5JA 4EIGA 1CD2A 3K74A 4X5HA 4FGHA 4QI9A 2AZNA 3FRDX 3FY8X 1DIUA 3JW5A 4KJKA 1DR1A 4Q6AA 4XT7A 5U26A 4NX6A 1RG7A 3QLZA 3EEMA 4GH8A 1KMVA 5HI6A 3ZPCA 1BOZA 1RE7A 3K45A 4P68A 1CZ3A 4LAHX 5HQYA 4XRBA 3EEJA 3DL6A 2H2QA 4KBNA 1U70A 3QLRA 1RA8A 4DP3A 3EEKA 1J3KA 5HQZA 3DATA 2L28A 3DAUA 1RF7A 3FREX 4CD2A 3OAFA 1RX3A 3GI2A 4TU5X 5HUIA 3IRMA 2W3MA 2W3AA 1JUVA 4PTHA 2FZHA 1AOEA 4IXED 2BLAA 1DR2A 3F0VX 3TQ9A 3NZDA 4DFRA 2FZIA 4KNEA 3JWCA 2C2SA 5CCCA 2OIPA 3NXXA 3Q1HA 5HT5A 3M08A 3NXYA 4M6JA 4Q0EA 5JA3A 3FQVA 5DFRA 4IXGX 4X5IA 5HSUA 4ELFA 4H95A 3VCOA 2ITHA 4DDRA 1JOMA 1M7AA 3JWMA 3JTWA 3NXRA 4KJJA 3S9UA 1LUDA 1U72A 1D1GA 2ZZAA 4ELEA 4IXFX 2OBCA 1DLRA 1RC4A 3I3RA 4FGGA 2CIGA 2QK8A 3QFXA 1KLKA 4PTJA 3F0UX 1S3WA 1DHIA 2W9TA 3DRCA 3LG4A 3K47A 4I13A 1DLSA 3F8YA 1PD9A 3KY8A 1RX2A 5CC9A 2BL9A 3NXVA 3NZAX 5EAJA 3GHVA 3CL9A 1DG5A 7DFRA 3IA5A 3RG9A 3IA4A 3QL3A 3F0XX 4P66A 3SQYX 3QYLA 4QLEA 4M7UA 1DDRA 1IA1A 4PDJA 3TQ8A 3QG2A 4KM2A 4LAGX 4QJCA 4OSGA 2O7PA 5U27A 3KJRA 2G6VA 4LEKX 4G3MA 1YHOA 1LY4A 3I8AX 4ELHA 3TD8A 3M09A 3DG8A 1RA2A 3NXTA 1VJ3A 3SRWX 3F0QX 3GHWA 3S3VA 3KJSA 4ECKA 4G95A 3F0BX 4KY4A 1IA3A 4KD7A 2KGKA 1AO8A 5HSRA 4EJ1A 4Q0DA 1IA2A 5HPBA 2FZJA 4KM0A 3FQ0A 1DHJA 3FS6A 3CSEA 3DFRA 2JYBA 4QJZD 4PSYA 1HFQA 1QZFA 3GHCA 1DYIA 4ELBA 4FHBA 1PDBA 1RX4A 3FRBX 2W3WA 1DYRA 3NXOA 3F8ZA 3FYWX 3D84X 4I1NA 3SRUX 1VDRA 4KJLA 3QLXA 3UM6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XW7 A;  1RX8 A;  4ELG A;  1J3I A;  3SA2 A;  4RGC A;  3R33 A;  3IRO A;  4XEC X;  3N0H A;  6DFR A;  4H98 A;  3QL0 A;  1JOL A;  4XT8 A;  3TQB A;  3KFY A;  3NU0 A;  4XE6 X;  2P4G A;  2LF1 A;  5HVE A;  3F0S X;  3F91 A;  2B3Z A;  3QYO A;  1DR6 A;  4PSS A;  1RX9 A;  2DHF A;  1SEJ A;  2ANO A;  4HA7 A;  4M6K A;  3HJ3 A;  3NRR A;  1S3V A;  2CD2 A;  3JVX A;  1RB3 A;  5HVB A;  3KGY A;  4DPH A;  3FQF A;  1DR5 A;  3SR5 X;  2W9S A;  4KY8 A;  1M79 A;  1DRF A;  3E0B A;  4QHV A;  5DXV A;  1HFP A;  1RX5 A;  4P3Q A;  1DYH A;  3GYF A;  3CD2 A;  1DR3 A;  1OHJ A;  4X5G A;  3SGY A;  1DDS A;  3FRA X;  4HA9 A;  2INQ A;  1MVS A;  3QLW A;  2HM9 A;  5E8Q A;  3UM8 A;  1DHF A;  4H96 A;  2W9H A;  1J3J A;  3DGA A;  4NX7 A;  3INV A;  3FQO A;  4LAE X;  4KFJ A;  1RA3 A;  4QLG A;  4G8Z X;  3D80 A;  4H97 A;  1RD7 A;  1RX1 A;  3FL9 A;  1S3U A;  1ZDR A;  4KAK A;  4Q67 A;  1DRH A;  1DF7 A;  1RA1 A;  2ANQ A;  3RO9 A;  2BLC A;  3JWF A;  1DIS A;  5HF2 X;  5HF0 X;  1DRB A;  4M6L A;  4HOE A;  1KMS A;  2BLB A;  5ECC A;  4PST A;  1DG8 A;  4HOF A;  3HBB A;  1DG7 A;  1DR7 A;  4P3R A;  3L3R A;  1HFR A;  3NZB X;  3IX9 A;  3EX8 A;  4KEB A;  2W9G A;  3QLY A;  3SRS X;  3ZPG A;  3NTZ A;  4EIZ A;  3SAI A;  2C2T A;  2GD9 A;  3K2H A;  1DR4 A;  2W3B A;  1MVT A;  1DAJ A;  3DL5 A;  3FQZ A;  3JSU A;  2D5N A;  3FYV X;  3NZ9 X;  5HT4 A;  1U71 A;  4HOG A;  2HXV A;  1RA9 A;  1S3Y A;  4OR7 A;  2HQP A;  4XT4 A;  4M7V A;  3NZ6 X;  3SRR X;  3TQA A;  1RB2 A;  1DYJ A;  3EIG A;  3OCH A;  4EIL A;  3CLB A;  3FY9 X;  3SRQ X;  1DRE A;  1AI9 A;  3FQC A;  4DPD A;  2D0K A;  5FDA A;  4KLX A;  3SH2 A;  1DRA A;  1M78 A;  4KL9 A;  4KYA A;  3SA1 A;  3S7A A;  2W3V A;  4XT5 A;  3NZC X;  3ROA A;  3EEL A;  1OHK A;  1LY3 A;  3JW3 A;  4QLF A;  8DFR A;  4XT6 A;  3IRN A;  1BZF A;  3FRF X;  3QLS A;  1RH3 A;  2DRC A;  1PD8 A;  1RX6 A;  5ECX A;  1E26 A;  4X5F A;  3UM5 A;  1IA4 A;  1TDR A;  5JG0 X;  1RX7 A;  3QGT A;  4M2X A;  3FL8 A;  3JWK A;  4X5J A;  4EIG A;  1CD2 A;  3K74 A;  4X5H A;  4FGH A;  4QI9 A;  2AZN A;  3FRD X;  3FY8 X;  1DIU A;  3JW5 A;  4KJK A;  1DR1 A;  4Q6A A;  4XT7 A;  5U26 A;  4NX6 A;  1RG7 A;  3QLZ A;  3EEM A;  4GH8 A;  1KMV A;  5HI6 A;  3ZPC A;  1BOZ A;  1RE7 A;  3K45 A;  4P68 A;  1CZ3 A;  4LAH X;  5HQY A;  4XRB A;  3EEJ A;  3DL6 A;  2H2Q A;  4KBN A;  1U70 A;  3QLR A;  1RA8 A;  4DP3 A;  3EEK A;  1J3K A;  5HQZ A;  3DAT A;  2L28 A;  3DAU A;  1RF7 A;  3FRE X;  4CD2 A;  3OAF A;  1RX3 A;  3GI2 A;  4TU5 X;  5HUI A;  3IRM A;  2W3M A;  2W3A A;  1JUV A;  4PTH A;  2FZH A;  1AOE A;  4IXE D;  2BLA A;  1DR2 A;  3F0V X;  3TQ9 A;  3NZD A;  4DFR A;  2FZI A;  4KNE A;  3JWC A;  2C2S A;  5CCC A;  2OIP A;  3NXX A;  3Q1H A;  5HT5 A;  3M08 A;  3NXY A;  4M6J A;  4Q0E A;  5JA3 A;  3FQV A;  5DFR A;  4IXG X;  4X5I A;  5HSU A;  4ELF A;  4H95 A;  3VCO A;  2ITH A;  4DDR A;  1JOM A;  1M7A A;  3JWM A;  3JTW A;  3NXR A;  4KJJ A;  3S9U A;  1LUD A;  1U72 A;  1D1G A;  2ZZA A;  4ELE A;  4IXF X;  2OBC A;  1DLR A;  1RC4 A;  3I3R A;  4FGG A;  2CIG A;  2QK8 A;  3QFX A;  1KLK A;  4PTJ A;  3F0U X;  1S3W A;  1DHI A;  2W9T A;  3DRC A;  3LG4 A;  3K47 A;  4I13 A;  1DLS A;  3F8Y A;  1PD9 A;  3KY8 A;  1RX2 A;  5CC9 A;  2BL9 A;  3NXV A;  3NZA X;  5EAJ A;  3GHV A;  3CL9 A;  1DG5 A;  7DFR A;  3IA5 A;  3RG9 A;  3IA4 A;  3QL3 A;  3F0X X;  4P66 A;  3SQY X;  3QYL A;  4QLE A;  4M7U A;  1DDR A;  1IA1 A;  4PDJ A;  3TQ8 A;  3QG2 A;  4KM2 A;  4LAG X;  4QJC A;  4OSG A;  2O7P A;  5U27 A;  3KJR A;  2G6V A;  4LEK X;  4G3M A;  1YHO A;  1LY4 A;  3I8A X;  4ELH A;  3TD8 A;  3M09 A;  3DG8 A;  1RA2 A;  3NXT A;  1VJ3 A;  3SRW X;  3F0Q X;  3GHW A;  3S3V A;  3KJS A;  4ECK A;  4G95 A;  3F0B X;  4KY4 A;  1IA3 A;  4KD7 A;  2KGK A;  1AO8 A;  5HSR A;  4EJ1 A;  4Q0D A;  1IA2 A;  5HPB A;  2FZJ A;  4KM0 A;  3FQ0 A;  1DHJ A;  3FS6 A;  3CSE A;  3DFR A;  2JYB A;  4QJZ D;  4PSY A;  1HFQ A;  1QZF A;  3GHC A;  1DYI A;  4ELB A;  4FHB A;  1PDB A;  1RX4 A;  3FRB X;  2W3W A;  1DYR A;  3NXO A;  3F8Z A;  3FYW X;  3D84 X;  4I1N A;  3SRU X;  1VDR A;  4KJL A;  3QLX A;  3UM6 A; 
#chains in the Genus database with same CATH topology
 2XW7 A;  1RX8 A;  4ELG A;  1J3I A;  3SA2 A;  4RGC A;  3R33 A;  3IRO A;  4XEC X;  3N0H A;  6DFR A;  4H98 A;  3QL0 A;  1JOL A;  4XT8 A;  3TQB A;  3KFY A;  3NU0 A;  4XE6 X;  2P4G A;  2LF1 A;  5HVE A;  3F0S X;  3F91 A;  2B3Z A;  3QYO A;  1DR6 A;  4PSS A;  1RX9 A;  2DHF A;  1SEJ A;  2ANO A;  4HA7 A;  4M6K A;  3HJ3 A;  3NRR A;  1S3V A;  2CD2 A;  3JVX A;  1RB3 A;  5HVB A;  3KGY A;  4DPH A;  3FQF A;  1DR5 A;  3SR5 X;  2W9S A;  4KY8 A;  1M79 A;  1DRF A;  3E0B A;  4QHV A;  5DXV A;  1HFP A;  1RX5 A;  4P3Q A;  1DYH A;  3GYF A;  3CD2 A;  1DR3 A;  1OHJ A;  4X5G A;  3SGY A;  1DDS A;  3FRA X;  4HA9 A;  2INQ A;  1MVS A;  3QLW A;  2HM9 A;  5E8Q A;  3UM8 A;  1DHF A;  4H96 A;  2W9H A;  1J3J A;  3DGA A;  4NX7 A;  3INV A;  3FQO A;  4LAE X;  4KFJ A;  1RA3 A;  4QLG A;  4G8Z X;  3D80 A;  4H97 A;  1RD7 A;  1RX1 A;  3FL9 A;  1S3U A;  1ZDR A;  4KAK A;  4Q67 A;  1DRH A;  1DF7 A;  1RA1 A;  2ANQ A;  3RO9 A;  2BLC A;  3JWF A;  1DIS A;  5HF2 X;  5HF0 X;  1DRB A;  4M6L A;  4HOE A;  1KMS A;  2BLB A;  5ECC A;  4PST A;  1DG8 A;  4HOF A;  3HBB A;  1DG7 A;  1DR7 A;  4P3R A;  3L3R A;  1HFR A;  3NZB X;  3IX9 A;  3EX8 A;  4KEB A;  2W9G A;  3QLY A;  3SRS X;  3ZPG A;  3NTZ A;  4EIZ A;  3SAI A;  2C2T A;  2GD9 A;  3K2H A;  1DR4 A;  2W3B A;  1MVT A;  1DAJ A;  3DL5 A;  3FQZ A;  3JSU A;  2D5N A;  3FYV X;  3NZ9 X;  5HT4 A;  1U71 A;  4HOG A;  2HXV A;  1RA9 A;  1S3Y A;  4OR7 A;  2HQP A;  4XT4 A;  4M7V A;  3NZ6 X;  3SRR X;  3TQA A;  1RB2 A;  1DYJ A;  3EIG A;  3OCH A;  4EIL A;  3CLB A;  3FY9 X;  3SRQ X;  1DRE A;  1AI9 A;  3FQC A;  4DPD A;  2D0K A;  5FDA A;  4KLX A;  3SH2 A;  1DRA A;  1M78 A;  4KL9 A;  4KYA A;  3SA1 A;  3S7A A;  2W3V A;  4XT5 A;  3NZC X;  3ROA A;  3EEL A;  1OHK A;  1LY3 A;  3JW3 A;  4QLF A;  8DFR A;  4XT6 A;  3IRN A;  1BZF A;  3FRF X;  3QLS A;  1RH3 A;  2DRC A;  1PD8 A;  1RX6 A;  5ECX A;  1E26 A;  4X5F A;  3UM5 A;  1IA4 A;  1TDR A;  5JG0 X;  1RX7 A;  3QGT A;  4M2X A;  3FL8 A;  3JWK A;  4X5J A;  4EIG A;  1CD2 A;  3K74 A;  4X5H A;  4FGH A;  4QI9 A;  2AZN A;  3FRD X;  3FY8 X;  1DIU A;  3JW5 A;  4KJK A;  1DR1 A;  4Q6A A;  4XT7 A;  5U26 A;  4NX6 A;  1RG7 A;  3QLZ A;  3EEM A;  4GH8 A;  1KMV A;  5HI6 A;  3ZPC A;  1BOZ A;  1RE7 A;  3K45 A;  4P68 A;  1CZ3 A;  4LAH X;  5HQY A;  4XRB A;  3EEJ A;  3DL6 A;  2H2Q A;  4KBN A;  1U70 A;  3QLR A;  1RA8 A;  4DP3 A;  3EEK A;  1J3K A;  5HQZ A;  3DAT A;  2L28 A;  3DAU A;  1RF7 A;  3FRE X;  4CD2 A;  3OAF A;  1RX3 A;  3GI2 A;  4TU5 X;  5HUI A;  3IRM A;  2W3M A;  2W3A A;  1JUV A;  4PTH A;  2FZH A;  1AOE A;  4IXE D;  2BLA A;  1DR2 A;  3F0V X;  3TQ9 A;  3NZD A;  4DFR A;  2FZI A;  4KNE A;  3JWC A;  2C2S A;  5CCC A;  2OIP A;  3NXX A;  3Q1H A;  5HT5 A;  3M08 A;  3NXY A;  4M6J A;  4Q0E A;  5JA3 A;  3FQV A;  5DFR A;  4IXG X;  4X5I A;  5HSU A;  4ELF A;  4H95 A;  3VCO A;  2ITH A;  4DDR A;  1JOM A;  1M7A A;  3JWM A;  3JTW A;  3NXR A;  4KJJ A;  3S9U A;  1LUD A;  1U72 A;  1D1G A;  2ZZA A;  4ELE A;  4IXF X;  2OBC A;  1DLR A;  1RC4 A;  3I3R A;  4FGG A;  2CIG A;  2QK8 A;  3QFX A;  1KLK A;  4PTJ A;  3F0U X;  1S3W A;  1DHI A;  2W9T A;  3DRC A;  3LG4 A;  3K47 A;  4I13 A;  1DLS A;  3F8Y A;  1PD9 A;  3KY8 A;  1RX2 A;  5CC9 A;  2BL9 A;  3NXV A;  3NZA X;  5EAJ A;  3GHV A;  3CL9 A;  1DG5 A;  7DFR A;  3IA5 A;  3RG9 A;  3IA4 A;  3QL3 A;  3F0X X;  4P66 A;  3SQY X;  3QYL A;  4QLE A;  4M7U A;  1DDR A;  1IA1 A;  4PDJ A;  3TQ8 A;  3QG2 A;  4KM2 A;  4LAG X;  4QJC A;  4OSG A;  2O7P A;  5U27 A;  3KJR A;  2G6V A;  4LEK X;  4G3M A;  1YHO A;  1LY4 A;  3I8A X;  4ELH A;  3TD8 A;  3M09 A;  3DG8 A;  1RA2 A;  3NXT A;  1VJ3 A;  3SRW X;  3F0Q X;  3GHW A;  3S3V A;  3KJS A;  4ECK A;  4G95 A;  3F0B X;  4KY4 A;  1IA3 A;  4KD7 A;  2KGK A;  1AO8 A;  5HSR A;  4EJ1 A;  4Q0D A;  1IA2 A;  5HPB A;  2FZJ A;  4KM0 A;  3FQ0 A;  1DHJ A;  3FS6 A;  3CSE A;  3DFR A;  2JYB A;  4QJZ D;  4PSY A;  1HFQ A;  1QZF A;  3GHC A;  1DYI A;  4ELB A;  4FHB A;  1PDB A;  1RX4 A;  3FRB X;  2W3W A;  1DYR A;  3NXO A;  3F8Z A;  3FYW X;  3D84 X;  4I1N A;  3SRU X;  1VDR A;  4KJL A;  3QLX A;  3UM6 A; 
#chains in the Genus database with same CATH homology
 2XW7 A;  1RX8 A;  4ELG A;  1J3I A;  3SA2 A;  4RGC A;  3R33 A;  3IRO A;  4XEC X;  3N0H A;  6DFR A;  4H98 A;  3QL0 A;  1JOL A;  4XT8 A;  3TQB A;  3KFY A;  3NU0 A;  4XE6 X;  2P4G A;  2LF1 A;  5HVE A;  3F0S X;  3F91 A;  2B3Z A;  3QYO A;  1DR6 A;  4PSS A;  1RX9 A;  2DHF A;  1SEJ A;  2ANO A;  4HA7 A;  4M6K A;  3HJ3 A;  3NRR A;  1S3V A;  2CD2 A;  3JVX A;  1RB3 A;  5HVB A;  3KGY A;  4DPH A;  3FQF A;  1DR5 A;  3SR5 X;  2W9S A;  4KY8 A;  1M79 A;  1DRF A;  3E0B A;  4QHV A;  5DXV A;  1HFP A;  1RX5 A;  4P3Q A;  1DYH A;  3GYF A;  3CD2 A;  1DR3 A;  1OHJ A;  4X5G A;  3SGY A;  1DDS A;  3FRA X;  4HA9 A;  2INQ A;  1MVS A;  3QLW A;  2HM9 A;  5E8Q A;  3UM8 A;  1DHF A;  4H96 A;  2W9H A;  1J3J A;  3DGA A;  4NX7 A;  3INV A;  3FQO A;  4LAE X;  4KFJ A;  1RA3 A;  4QLG A;  4G8Z X;  3D80 A;  4H97 A;  1RD7 A;  1RX1 A;  3FL9 A;  1S3U A;  1ZDR A;  4KAK A;  4Q67 A;  1DRH A;  1DF7 A;  1RA1 A;  2ANQ A;  3RO9 A;  2BLC A;  3JWF A;  1DIS A;  5HF2 X;  5HF0 X;  1DRB A;  4M6L A;  4HOE A;  1KMS A;  2BLB A;  5ECC A;  4PST A;  1DG8 A;  4HOF A;  3HBB A;  1DG7 A;  1DR7 A;  4P3R A;  3L3R A;  1HFR A;  3NZB X;  3IX9 A;  3EX8 A;  4KEB A;  2W9G A;  3QLY A;  3SRS X;  3ZPG A;  3NTZ A;  4EIZ A;  3SAI A;  2C2T A;  2GD9 A;  3K2H A;  1DR4 A;  2W3B A;  1MVT A;  1DAJ A;  3DL5 A;  3FQZ A;  3JSU A;  2D5N A;  3FYV X;  3NZ9 X;  5HT4 A;  1U71 A;  4HOG A;  2HXV A;  1RA9 A;  1S3Y A;  4OR7 A;  2HQP A;  4XT4 A;  4M7V A;  3NZ6 X;  3SRR X;  3TQA A;  1RB2 A;  1DYJ A;  3EIG A;  3OCH A;  4EIL A;  3CLB A;  3FY9 X;  3SRQ X;  1DRE A;  1AI9 A;  3FQC A;  4DPD A;  2D0K A;  5FDA A;  4KLX A;  3SH2 A;  1DRA A;  1M78 A;  4KL9 A;  4KYA A;  3SA1 A;  3S7A A;  2W3V A;  4XT5 A;  3NZC X;  3ROA A;  3EEL A;  1OHK A;  1LY3 A;  3JW3 A;  4QLF A;  8DFR A;  4XT6 A;  3IRN A;  1BZF A;  3FRF X;  3QLS A;  1RH3 A;  2DRC A;  1PD8 A;  1RX6 A;  5ECX A;  1E26 A;  4X5F A;  3UM5 A;  1IA4 A;  1TDR A;  5JG0 X;  1RX7 A;  3QGT A;  4M2X A;  3FL8 A;  3JWK A;  4X5J A;  4EIG A;  1CD2 A;  3K74 A;  4X5H A;  4FGH A;  4QI9 A;  2AZN A;  3FRD X;  3FY8 X;  1DIU A;  3JW5 A;  4KJK A;  1DR1 A;  4Q6A A;  4XT7 A;  5U26 A;  4NX6 A;  1RG7 A;  3QLZ A;  3EEM A;  4GH8 A;  1KMV A;  5HI6 A;  3ZPC A;  1BOZ A;  1RE7 A;  3K45 A;  4P68 A;  1CZ3 A;  4LAH X;  5HQY A;  4XRB A;  3EEJ A;  3DL6 A;  2H2Q A;  4KBN A;  1U70 A;  3QLR A;  1RA8 A;  4DP3 A;  3EEK A;  1J3K A;  5HQZ A;  3DAT A;  2L28 A;  3DAU A;  1RF7 A;  3FRE X;  4CD2 A;  3OAF A;  1RX3 A;  3GI2 A;  4TU5 X;  5HUI A;  3IRM A;  2W3M A;  2W3A A;  1JUV A;  4PTH A;  2FZH A;  1AOE A;  4IXE D;  2BLA A;  1DR2 A;  3F0V X;  3TQ9 A;  3NZD A;  4DFR A;  2FZI A;  4KNE A;  3JWC A;  2C2S A;  5CCC A;  2OIP A;  3NXX A;  3Q1H A;  5HT5 A;  3M08 A;  3NXY A;  4M6J A;  4Q0E A;  5JA3 A;  3FQV A;  5DFR A;  4IXG X;  4X5I A;  5HSU A;  4ELF A;  4H95 A;  3VCO A;  2ITH A;  4DDR A;  1JOM A;  1M7A A;  3JWM A;  3JTW A;  3NXR A;  4KJJ A;  3S9U A;  1LUD A;  1U72 A;  1D1G A;  2ZZA A;  4ELE A;  4IXF X;  2OBC A;  1DLR A;  1RC4 A;  3I3R A;  4FGG A;  2CIG A;  2QK8 A;  3QFX A;  1KLK A;  4PTJ A;  3F0U X;  1S3W A;  1DHI A;  2W9T A;  3DRC A;  3LG4 A;  3K47 A;  4I13 A;  1DLS A;  3F8Y A;  1PD9 A;  3KY8 A;  1RX2 A;  5CC9 A;  2BL9 A;  3NXV A;  3NZA X;  5EAJ A;  3GHV A;  3CL9 A;  1DG5 A;  7DFR A;  3IA5 A;  3RG9 A;  3IA4 A;  3QL3 A;  3F0X X;  4P66 A;  3SQY X;  3QYL A;  4QLE A;  4M7U A;  1DDR A;  1IA1 A;  4PDJ A;  3TQ8 A;  3QG2 A;  4KM2 A;  4LAG X;  4QJC A;  4OSG A;  2O7P A;  5U27 A;  3KJR A;  2G6V A;  4LEK X;  4G3M A;  1YHO A;  1LY4 A;  3I8A X;  4ELH A;  3TD8 A;  3M09 A;  3DG8 A;  1RA2 A;  3NXT A;  1VJ3 A;  3SRW X;  3F0Q X;  3GHW A;  3S3V A;  3KJS A;  4ECK A;  4G95 A;  3F0B X;  4KY4 A;  1IA3 A;  4KD7 A;  2KGK A;  1AO8 A;  5HSR A;  4EJ1 A;  4Q0D A;  1IA2 A;  5HPB A;  2FZJ A;  4KM0 A;  3FQ0 A;  1DHJ A;  3FS6 A;  3CSE A;  3DFR A;  2JYB A;  4QJZ D;  4PSY A;  1HFQ A;  1QZF A;  3GHC A;  1DYI A;  4ELB A;  4FHB A;  1PDB A;  1RX4 A;  3FRB X;  2W3W A;  1DYR A;  3NXO A;  3F8Z A;  3FYW X;  3D84 X;  4I1N A;  3SRU X;  1VDR A;  4KJL A;  3QLX A;  3UM6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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