3OAFA

Structural and kinetic data for antifolate interactions against pneumocystis jirovecii, pneumocystis carinii and human dihydrofolate reductase and thier active site mutants
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFSRMTTTSSVEGKQNLVIMGKKTWFSIPEKFRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants.
pubmed doi rcsb
molecule tags Oxidoreductase/inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 54
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-08-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3oafA00
2BLBA 1RG7A 1HFQA 1DIUA 5EAJA 3FQ0A 2HQPA 4PTJA 4DPHA 4XT4A 2W3BA 3DAUA 1TDRA 3GYFA 1SEJA 8DFRA 3TQ8A 2DRCA 3RO9A 2GD9A 1M79A 4KM2A 2OBCA 3QLRA 3GHCA 1PD8A 3QLXA 5HF0X 5U26A 1RX4A 2W9HA 1VJ3A 1DRHA 1LY3A 1IA1A 5HQZA 1RE7A 2HXVA 3GHVA 2W9GA 5ECXA 5ECCA 3DRCA 3DG8A 3KJRA 3F0BX 1JOLA 3FQCA 1DLSA 3E0BA 1RF7A 2FZJA 4EIZA 3FRBX 3D84X 4H96A 1M7AA 3NZBX 3SH2A 3F91A 3KJSA 3IA5A 3TQ9A 2W3WA 1J3IA 3UM6A 4P3RA 4XT6A 3QYOA 5CC9A 3I3RA 1DHJA 2KGKA 3NXRA 1MVSA 3F0SX 4ELBA 2ZZAA 3SR5X 2DHFA 5HT4A 1DR7A 2W9TA 3FRFX 2O7PA 1DRBA 4G8ZX 1KMSA 3DL6A 2D5NA 4X5GA 1YHOA 3K2HA 4LAEX 3FY9X 4ELHA 4ELFA 3TQBA 4KL9A 3QLSA 4M7UA 3Q1HA 3FQVA 3FRDX 1DR5A 1ZDRA 3CSEA 2OIPA 3FREX 3JSUA 3EELA 1RH3A 3D80A 4QJCA 3NXYA 2CIGA 1JUVA 1J3KA 1RX3A 5U27A 3NU0A 3JW3A 3NXOA 1DRAA 4IXED 4KY4A 3JWMA 3K47A 1CD2A 4KYAA 3SRWX 3SRRX 1DR1A 3N0HA 3QLWA 3NXVA 3QLYA 3JWFA 3CD2A 4IXFX 4LEKX 3NXTA 5DFRA 4QJZD 3DFRA 3IROA 1BOZA 2W9SA 4CD2A 1DG7A 1RX7A 2INQA 4H97A 2FZIA 2P4GA 1DF7A 3K45A 1S3UA 4M6LA 1J3JA 3FL9A 4FGHA 4Q0EA 1DLRA 1RB3A 4P3QA 4FHBA 1LY4A 4QHVA 1DG5A 4TU5X 5E8QA 4H98A 1RX5A 1DRFA 3JWKA 3QLZA 3K74A 2L28A 1IA2A 4PSYA 3S3VA 3NTZA 3F0VX 3OCHA 4XECX 4QLFA 1AO8A 3HBBA 2W3VA 4G3MA 3NRRA 4XRBA 2ANQA 7DFRA 3FL8A 4IXGX 4Q6AA 1DR6A 3UM5A 5HI6A 5HSUA 2ITHA 1S3WA 2B3ZA 1RA3A 2ANOA 3LG4A 4KLXA 3TQAA 1DYHA 5HUIA 4Q0DA 3KY8A 1RC4A 4HA9A 1PD9A 2G6VA 4X5JA 5HPBA 4RGCA 5JA3A 2QK8A 1M78A 3KGYA 1S3YA 3QG2A 3QGTA 3SRQX 4KEBA 5HSRA 3CLBA 1DYJA 3VCOA 1DDRA 3GHWA 3TD8A 4ELEA 4P68A 3KFYA 3NZ9X 3GI2A 5JG0X 4X5FA 4DPDA 3JTWA 3JW5A 1IA4A 1MVTA 2JYBA 4XT5A 3QYLA 5HVEA 4X5IA 1DHIA 1DG8A 4G95A 6DFRA 3SA2A 3RG9A 4HOFA 3ZPCA 1RA1A 3SRUX 3DGAA 3FY8X 3IX9A 3F8YA 1DYRA 1DISA 4KM0A 4KAKA 2AZNA 2LF1A 4Q67A 3F0QX 3DATA 2C2SA 1DREA 3QFXA 3M08A 4EJ1A 3F0UX 1DYIA 4I1NA 5HF2X 4KJLA 1DR3A 4M6JA 3EEMA 2BLAA 4KFJA 3SA1A 1RB2A 2W3MA 4HOEA 4PSSA 1RX1A 3FRAX 5HT5A 4H95A 4M6KA 1JOMA 2BLCA 4XT8A 1OHKA 3QL0A 4PDJA 3ZPGA 1HFRA 4EILA 3HJ3A 5FDAA 1HFPA 1DAJA 2C2TA 1RA8A 2D0KA 1RD7A 3FYVX 3JVXA 5HVBA 4QLEA 3M09A 5CCCA 3F0XX 3EX8A 1KLKA 1DR4A 4KJJA 3IRMA 3L3RA 4KJKA 1OHJA 3CL9A 2XW7A 4KY8A 4OR7A 3IRNA 3SRSX 3FQZA 3ROAA 2H2QA 4OSGA 4GH8A 4PTHA 1D1GA 3FS6A 4FGGA 3INVA 3JWCA 3EEJA 2CD2A 1RA9A 1KMVA 4HOGA 4QLGA 4DP3A 4DFRA 4KNEA 4X5HA 3EIGA 1RA2A 3UM8A 3FQOA 4KBNA 4XE6X 1VDRA 3S7AA 1RX8A 4I13A 3SQYX 4PSTA 3FYWX 1U72A 2FZHA 5DXVA 5HQYA 3NZ6X 3NZDA 3S9UA 4EIGA 3QL3A 3NZAX 3NZCX 4M2XA 1RX6A 4XT7A 3DL5A 3FQFA 1RX9A 4HA7A 4DDRA 4ECKA 2HM9A 1DR2A 1U71A 4LAHX 1DDSA 1U70A 4LAGX 1AOEA 3SGYA 1PDBA 4M7VA 1IA3A 1BZFA 3EEKA 1E26A 1RX2A 3SAIA 3I8AX 1AI9A 3R33A 4QI9A 1DHFA 2W3AA 4NX6A 1LUDA 1S3VA 4ELGA 2BL9A 1CZ3A 4KD7A 4P66A 3F8ZA 4NX7A 3NXXA 3IA4A 3OAFA 1QZFA
chains in the Genus database with same CATH superfamily
2BLBA 1RG7A 1HFQA 1DIUA 5EAJA 3FQ0A 2HQPA 4PTJA 4DPHA 4XT4A 2W3BA 3DAUA 1TDRA 3GYFA 1SEJA 8DFRA 3TQ8A 2DRCA 3RO9A 2GD9A 1M79A 4KM2A 2OBCA 3QLRA 3GHCA 1PD8A 3QLXA 5HF0X 5U26A 1RX4A 2W9HA 1VJ3A 1DRHA 1LY3A 1IA1A 5HQZA 1RE7A 2HXVA 3GHVA 2W9GA 5ECXA 5ECCA 3DRCA 3DG8A 3KJRA 3F0BX 1JOLA 3FQCA 1DLSA 3E0BA 1RF7A 2FZJA 4EIZA 3FRBX 3D84X 4H96A 1M7AA 3NZBX 3SH2A 3F91A 3KJSA 3IA5A 3TQ9A 2W3WA 1J3IA 3UM6A 4P3RA 4XT6A 3QYOA 5CC9A 3I3RA 1DHJA 2KGKA 3NXRA 1MVSA 3F0SX 4ELBA 2ZZAA 3SR5X 2DHFA 5HT4A 1DR7A 2W9TA 3FRFX 2O7PA 1DRBA 4G8ZX 1KMSA 3DL6A 2D5NA 4X5GA 1YHOA 3K2HA 4LAEX 3FY9X 4ELHA 4ELFA 3TQBA 4KL9A 3QLSA 4M7UA 3Q1HA 3FQVA 3FRDX 1DR5A 1ZDRA 3CSEA 2OIPA 3FREX 3JSUA 3EELA 1RH3A 3D80A 4QJCA 3NXYA 2CIGA 1JUVA 1J3KA 1RX3A 5U27A 3NU0A 3JW3A 3NXOA 1DRAA 4IXED 4KY4A 3JWMA 3K47A 1CD2A 4KYAA 3SRWX 3SRRX 1DR1A 3N0HA 3QLWA 3NXVA 3QLYA 3JWFA 3CD2A 4IXFX 4LEKX 3NXTA 5DFRA 4QJZD 3DFRA 3IROA 1BOZA 2W9SA 4CD2A 1DG7A 1RX7A 2INQA 4H97A 2FZIA 2P4GA 1DF7A 3K45A 1S3UA 4M6LA 1J3JA 3FL9A 4FGHA 4Q0EA 1DLRA 1RB3A 4P3QA 4FHBA 1LY4A 4QHVA 1DG5A 4TU5X 5E8QA 4H98A 1RX5A 1DRFA 3JWKA 3QLZA 3K74A 2L28A 1IA2A 4PSYA 3S3VA 3NTZA 3F0VX 3OCHA 4XECX 4QLFA 1AO8A 3HBBA 2W3VA 4G3MA 3NRRA 4XRBA 2ANQA 7DFRA 3FL8A 4IXGX 4Q6AA 1DR6A 3UM5A 5HI6A 5HSUA 2ITHA 1S3WA 2B3ZA 1RA3A 2ANOA 3LG4A 4KLXA 3TQAA 1DYHA 5HUIA 4Q0DA 3KY8A 1RC4A 4HA9A 1PD9A 2G6VA 4X5JA 5HPBA 4RGCA 5JA3A 2QK8A 1M78A 3KGYA 1S3YA 3QG2A 3QGTA 3SRQX 4KEBA 5HSRA 3CLBA 1DYJA 3VCOA 1DDRA 3GHWA 3TD8A 4ELEA 4P68A 3KFYA 3NZ9X 3GI2A 5JG0X 4X5FA 4DPDA 3JTWA 3JW5A 1IA4A 1MVTA 2JYBA 4XT5A 3QYLA 5HVEA 4X5IA 1DHIA 1DG8A 4G95A 6DFRA 3SA2A 3RG9A 4HOFA 3ZPCA 1RA1A 3SRUX 3DGAA 3FY8X 3IX9A 3F8YA 1DYRA 1DISA 4KM0A 4KAKA 2AZNA 2LF1A 4Q67A 3F0QX 3DATA 2C2SA 1DREA 3QFXA 3M08A 4EJ1A 3F0UX 1DYIA 4I1NA 5HF2X 4KJLA 1DR3A 4M6JA 3EEMA 2BLAA 4KFJA 3SA1A 1RB2A 2W3MA 4HOEA 4PSSA 1RX1A 3FRAX 5HT5A 4H95A 4M6KA 1JOMA 2BLCA 4XT8A 1OHKA 3QL0A 4PDJA 3ZPGA 1HFRA 4EILA 3HJ3A 5FDAA 1HFPA 1DAJA 2C2TA 1RA8A 2D0KA 1RD7A 3FYVX 3JVXA 5HVBA 4QLEA 3M09A 5CCCA 3F0XX 3EX8A 1KLKA 1DR4A 4KJJA 3IRMA 3L3RA 4KJKA 1OHJA 3CL9A 2XW7A 4KY8A 4OR7A 3IRNA 3SRSX 3FQZA 3ROAA 2H2QA 4OSGA 4GH8A 4PTHA 1D1GA 3FS6A 4FGGA 3INVA 3JWCA 3EEJA 2CD2A 1RA9A 1KMVA 4HOGA 4QLGA 4DP3A 4DFRA 4KNEA 4X5HA 3EIGA 1RA2A 3UM8A 3FQOA 4KBNA 4XE6X 1VDRA 3S7AA 1RX8A 4I13A 3SQYX 4PSTA 3FYWX 1U72A 2FZHA 5DXVA 5HQYA 3NZ6X 3NZDA 3S9UA 4EIGA 3QL3A 3NZAX 3NZCX 4M2XA 1RX6A 4XT7A 3DL5A 3FQFA 1RX9A 4HA7A 4DDRA 4ECKA 2HM9A 1DR2A 1U71A 4LAHX 1DDSA 1U70A 4LAGX 1AOEA 3SGYA 1PDBA 4M7VA 1IA3A 1BZFA 3EEKA 1E26A 1RX2A 3SAIA 3I8AX 1AI9A 3R33A 4QI9A 1DHFA 2W3AA 4NX6A 1LUDA 1S3VA 4ELGA 2BL9A 1CZ3A 4KD7A 4P66A 3F8ZA 4NX7A 3NXXA 3IA4A 3OAFA 1QZFA
chains in the Genus database with same CATH topology
2BLBA 1RG7A 1HFQA 1DIUA 5EAJA 3FQ0A 2HQPA 4PTJA 4DPHA 4XT4A 2W3BA 3DAUA 1TDRA 3GYFA 1SEJA 8DFRA 3TQ8A 2DRCA 3RO9A 2GD9A 1M79A 4KM2A 2OBCA 3QLRA 3GHCA 1PD8A 3QLXA 5HF0X 5U26A 1RX4A 2W9HA 1VJ3A 1DRHA 1LY3A 1IA1A 5HQZA 1RE7A 2HXVA 3GHVA 2W9GA 5ECXA 5ECCA 3DRCA 3DG8A 3KJRA 3F0BX 1JOLA 3FQCA 1DLSA 3E0BA 1RF7A 2FZJA 4EIZA 3FRBX 3D84X 4H96A 1M7AA 3NZBX 3SH2A 3F91A 3KJSA 3IA5A 3TQ9A 2W3WA 1J3IA 3UM6A 4P3RA 4XT6A 3QYOA 5CC9A 3I3RA 1DHJA 2KGKA 3NXRA 1MVSA 3F0SX 4ELBA 2ZZAA 3SR5X 2DHFA 5HT4A 1DR7A 2W9TA 3FRFX 2O7PA 1DRBA 4G8ZX 1KMSA 3DL6A 2D5NA 4X5GA 1YHOA 3K2HA 4LAEX 3FY9X 4ELHA 4ELFA 3TQBA 4KL9A 3QLSA 4M7UA 3Q1HA 3FQVA 3FRDX 1DR5A 1ZDRA 3CSEA 2OIPA 3FREX 3JSUA 3EELA 1RH3A 3D80A 4QJCA 3NXYA 2CIGA 1JUVA 1J3KA 1RX3A 5U27A 3NU0A 3JW3A 3NXOA 1DRAA 4IXED 4KY4A 3JWMA 3K47A 1CD2A 4KYAA 3SRWX 3SRRX 1DR1A 3N0HA 3QLWA 3NXVA 3QLYA 3JWFA 3CD2A 4IXFX 4LEKX 3NXTA 5DFRA 4QJZD 3DFRA 3IROA 1BOZA 2W9SA 4CD2A 1DG7A 1RX7A 2INQA 4H97A 2FZIA 2P4GA 1DF7A 3K45A 1S3UA 4M6LA 1J3JA 3FL9A 4FGHA 4Q0EA 1DLRA 1RB3A 4P3QA 4FHBA 1LY4A 4QHVA 1DG5A 4TU5X 5E8QA 4H98A 1RX5A 1DRFA 3JWKA 3QLZA 3K74A 2L28A 1IA2A 4PSYA 3S3VA 3NTZA 3F0VX 3OCHA 4XECX 4QLFA 1AO8A 3HBBA 2W3VA 4G3MA 3NRRA 4XRBA 2ANQA 7DFRA 3FL8A 4IXGX 4Q6AA 1DR6A 3UM5A 5HI6A 5HSUA 2ITHA 1S3WA 2B3ZA 1RA3A 2ANOA 3LG4A 4KLXA 3TQAA 1DYHA 5HUIA 4Q0DA 3KY8A 1RC4A 4HA9A 1PD9A 2G6VA 4X5JA 5HPBA 4RGCA 5JA3A 2QK8A 1M78A 3KGYA 1S3YA 3QG2A 3QGTA 3SRQX 4KEBA 5HSRA 3CLBA 1DYJA 3VCOA 1DDRA 3GHWA 3TD8A 4ELEA 4P68A 3KFYA 3NZ9X 3GI2A 5JG0X 4X5FA 4DPDA 3JTWA 3JW5A 1IA4A 1MVTA 2JYBA 4XT5A 3QYLA 5HVEA 4X5IA 1DHIA 1DG8A 4G95A 6DFRA 3SA2A 3RG9A 4HOFA 3ZPCA 1RA1A 3SRUX 3DGAA 3FY8X 3IX9A 3F8YA 1DYRA 1DISA 4KM0A 4KAKA 2AZNA 2LF1A 4Q67A 3F0QX 3DATA 2C2SA 1DREA 3QFXA 3M08A 4EJ1A 3F0UX 1DYIA 4I1NA 5HF2X 4KJLA 1DR3A 4M6JA 3EEMA 2BLAA 4KFJA 3SA1A 1RB2A 2W3MA 4HOEA 4PSSA 1RX1A 3FRAX 5HT5A 4H95A 4M6KA 1JOMA 2BLCA 4XT8A 1OHKA 3QL0A 4PDJA 3ZPGA 1HFRA 4EILA 3HJ3A 5FDAA 1HFPA 1DAJA 2C2TA 1RA8A 2D0KA 1RD7A 3FYVX 3JVXA 5HVBA 4QLEA 3M09A 5CCCA 3F0XX 3EX8A 1KLKA 1DR4A 4KJJA 3IRMA 3L3RA 4KJKA 1OHJA 3CL9A 2XW7A 4KY8A 4OR7A 3IRNA 3SRSX 3FQZA 3ROAA 2H2QA 4OSGA 4GH8A 4PTHA 1D1GA 3FS6A 4FGGA 3INVA 3JWCA 3EEJA 2CD2A 1RA9A 1KMVA 4HOGA 4QLGA 4DP3A 4DFRA 4KNEA 4X5HA 3EIGA 1RA2A 3UM8A 3FQOA 4KBNA 4XE6X 1VDRA 3S7AA 1RX8A 4I13A 3SQYX 4PSTA 3FYWX 1U72A 2FZHA 5DXVA 5HQYA 3NZ6X 3NZDA 3S9UA 4EIGA 3QL3A 3NZAX 3NZCX 4M2XA 1RX6A 4XT7A 3DL5A 3FQFA 1RX9A 4HA7A 4DDRA 4ECKA 2HM9A 1DR2A 1U71A 4LAHX 1DDSA 1U70A 4LAGX 1AOEA 3SGYA 1PDBA 4M7VA 1IA3A 1BZFA 3EEKA 1E26A 1RX2A 3SAIA 3I8AX 1AI9A 3R33A 4QI9A 1DHFA 2W3AA 4NX6A 1LUDA 1S3VA 4ELGA 2BL9A 1CZ3A 4KD7A 4P66A 3F8ZA 4NX7A 3NXXA 3IA4A 3OAFA 1QZFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BLB A;  1RG7 A;  1HFQ A;  1DIU A;  5EAJ A;  3FQ0 A;  2HQP A;  4PTJ A;  4DPH A;  4XT4 A;  2W3B A;  3DAU A;  1TDR A;  3GYF A;  1SEJ A;  8DFR A;  3TQ8 A;  2DRC A;  3RO9 A;  2GD9 A;  1M79 A;  4KM2 A;  2OBC A;  3QLR A;  3GHC A;  1PD8 A;  3QLX A;  5HF0 X;  5U26 A;  1RX4 A;  2W9H A;  1VJ3 A;  1DRH A;  1LY3 A;  1IA1 A;  5HQZ A;  1RE7 A;  2HXV A;  3GHV A;  2W9G A;  5ECX A;  5ECC A;  3DRC A;  3DG8 A;  3KJR A;  3F0B X;  1JOL A;  3FQC A;  1DLS A;  3E0B A;  1RF7 A;  2FZJ A;  4EIZ A;  3FRB X;  3D84 X;  4H96 A;  1M7A A;  3NZB X;  3SH2 A;  3F91 A;  3KJS A;  3IA5 A;  3TQ9 A;  2W3W A;  1J3I A;  3UM6 A;  4P3R A;  4XT6 A;  3QYO A;  5CC9 A;  3I3R A;  1DHJ A;  2KGK A;  3NXR A;  1MVS A;  3F0S X;  4ELB A;  2ZZA A;  3SR5 X;  2DHF A;  5HT4 A;  1DR7 A;  2W9T A;  3FRF X;  2O7P A;  1DRB A;  4G8Z X;  1KMS A;  3DL6 A;  2D5N A;  4X5G A;  1YHO A;  3K2H A;  4LAE X;  3FY9 X;  4ELH A;  4ELF A;  3TQB A;  4KL9 A;  3QLS A;  4M7U A;  3Q1H A;  3FQV A;  3FRD X;  1DR5 A;  1ZDR A;  3CSE A;  2OIP A;  3FRE X;  3JSU A;  3EEL A;  1RH3 A;  3D80 A;  4QJC A;  3NXY A;  2CIG A;  1JUV A;  1J3K A;  1RX3 A;  5U27 A;  3NU0 A;  3JW3 A;  3NXO A;  1DRA A;  4IXE D;  4KY4 A;  3JWM A;  3K47 A;  1CD2 A;  4KYA A;  3SRW X;  3SRR X;  1DR1 A;  3N0H A;  3QLW A;  3NXV A;  3QLY A;  3JWF A;  3CD2 A;  4IXF X;  4LEK X;  3NXT A;  5DFR A;  4QJZ D;  3DFR A;  3IRO A;  1BOZ A;  2W9S A;  4CD2 A;  1DG7 A;  1RX7 A;  2INQ A;  4H97 A;  2FZI A;  2P4G A;  1DF7 A;  3K45 A;  1S3U A;  4M6L A;  1J3J A;  3FL9 A;  4FGH A;  4Q0E A;  1DLR A;  1RB3 A;  4P3Q A;  4FHB A;  1LY4 A;  4QHV A;  1DG5 A;  4TU5 X;  5E8Q A;  4H98 A;  1RX5 A;  1DRF A;  3JWK A;  3QLZ A;  3K74 A;  2L28 A;  1IA2 A;  4PSY A;  3S3V A;  3NTZ A;  3F0V X;  3OCH A;  4XEC X;  4QLF A;  1AO8 A;  3HBB A;  2W3V A;  4G3M A;  3NRR A;  4XRB A;  2ANQ A;  7DFR A;  3FL8 A;  4IXG X;  4Q6A A;  1DR6 A;  3UM5 A;  5HI6 A;  5HSU A;  2ITH A;  1S3W A;  2B3Z A;  1RA3 A;  2ANO A;  3LG4 A;  4KLX A;  3TQA A;  1DYH A;  5HUI A;  4Q0D A;  3KY8 A;  1RC4 A;  4HA9 A;  1PD9 A;  2G6V A;  4X5J A;  5HPB A;  4RGC A;  5JA3 A;  2QK8 A;  1M78 A;  3KGY A;  1S3Y A;  3QG2 A;  3QGT A;  3SRQ X;  4KEB A;  5HSR A;  3CLB A;  1DYJ A;  3VCO A;  1DDR A;  3GHW A;  3TD8 A;  4ELE A;  4P68 A;  3KFY A;  3NZ9 X;  3GI2 A;  5JG0 X;  4X5F A;  4DPD A;  3JTW A;  3JW5 A;  1IA4 A;  1MVT A;  2JYB A;  4XT5 A;  3QYL A;  5HVE A;  4X5I A;  1DHI A;  1DG8 A;  4G95 A;  6DFR A;  3SA2 A;  3RG9 A;  4HOF A;  3ZPC A;  1RA1 A;  3SRU X;  3DGA A;  3FY8 X;  3IX9 A;  3F8Y A;  1DYR A;  1DIS A;  4KM0 A;  4KAK A;  2AZN A;  2LF1 A;  4Q67 A;  3F0Q X;  3DAT A;  2C2S A;  1DRE A;  3QFX A;  3M08 A;  4EJ1 A;  3F0U X;  1DYI A;  4I1N A;  5HF2 X;  4KJL A;  1DR3 A;  4M6J A;  3EEM A;  2BLA A;  4KFJ A;  3SA1 A;  1RB2 A;  2W3M A;  4HOE A;  4PSS A;  1RX1 A;  3FRA X;  5HT5 A;  4H95 A;  4M6K A;  1JOM A;  2BLC A;  4XT8 A;  1OHK A;  3QL0 A;  4PDJ A;  3ZPG A;  1HFR A;  4EIL A;  3HJ3 A;  5FDA A;  1HFP A;  1DAJ A;  2C2T A;  1RA8 A;  2D0K A;  1RD7 A;  3FYV X;  3JVX A;  5HVB A;  4QLE A;  3M09 A;  5CCC A;  3F0X X;  3EX8 A;  1KLK A;  1DR4 A;  4KJJ A;  3IRM A;  3L3R A;  4KJK A;  1OHJ A;  3CL9 A;  2XW7 A;  4KY8 A;  4OR7 A;  3IRN A;  3SRS X;  3FQZ A;  3ROA A;  2H2Q A;  4OSG A;  4GH8 A;  4PTH A;  1D1G A;  3FS6 A;  4FGG A;  3INV A;  3JWC A;  3EEJ A;  2CD2 A;  1RA9 A;  1KMV A;  4HOG A;  4QLG A;  4DP3 A;  4DFR A;  4KNE A;  4X5H A;  3EIG A;  1RA2 A;  3UM8 A;  3FQO A;  4KBN A;  4XE6 X;  1VDR A;  3S7A A;  1RX8 A;  4I13 A;  3SQY X;  4PST A;  3FYW X;  1U72 A;  2FZH A;  5DXV A;  5HQY A;  3NZ6 X;  3NZD A;  3S9U A;  4EIG A;  3QL3 A;  3NZA X;  3NZC X;  4M2X A;  1RX6 A;  4XT7 A;  3DL5 A;  3FQF A;  1RX9 A;  4HA7 A;  4DDR A;  4ECK A;  2HM9 A;  1DR2 A;  1U71 A;  4LAH X;  1DDS A;  1U70 A;  4LAG X;  1AOE A;  3SGY A;  1PDB A;  4M7V A;  1IA3 A;  1BZF A;  3EEK A;  1E26 A;  1RX2 A;  3SAI A;  3I8A X;  1AI9 A;  3R33 A;  4QI9 A;  1DHF A;  2W3A A;  4NX6 A;  1LUD A;  1S3V A;  4ELG A;  2BL9 A;  1CZ3 A;  4KD7 A;  4P66 A;  3F8Z A;  4NX7 A;  3NXX A;  3IA4 A;  3OAF A;  1QZF A; 
#chains in the Genus database with same CATH topology
 2BLB A;  1RG7 A;  1HFQ A;  1DIU A;  5EAJ A;  3FQ0 A;  2HQP A;  4PTJ A;  4DPH A;  4XT4 A;  2W3B A;  3DAU A;  1TDR A;  3GYF A;  1SEJ A;  8DFR A;  3TQ8 A;  2DRC A;  3RO9 A;  2GD9 A;  1M79 A;  4KM2 A;  2OBC A;  3QLR A;  3GHC A;  1PD8 A;  3QLX A;  5HF0 X;  5U26 A;  1RX4 A;  2W9H A;  1VJ3 A;  1DRH A;  1LY3 A;  1IA1 A;  5HQZ A;  1RE7 A;  2HXV A;  3GHV A;  2W9G A;  5ECX A;  5ECC A;  3DRC A;  3DG8 A;  3KJR A;  3F0B X;  1JOL A;  3FQC A;  1DLS A;  3E0B A;  1RF7 A;  2FZJ A;  4EIZ A;  3FRB X;  3D84 X;  4H96 A;  1M7A A;  3NZB X;  3SH2 A;  3F91 A;  3KJS A;  3IA5 A;  3TQ9 A;  2W3W A;  1J3I A;  3UM6 A;  4P3R A;  4XT6 A;  3QYO A;  5CC9 A;  3I3R A;  1DHJ A;  2KGK A;  3NXR A;  1MVS A;  3F0S X;  4ELB A;  2ZZA A;  3SR5 X;  2DHF A;  5HT4 A;  1DR7 A;  2W9T A;  3FRF X;  2O7P A;  1DRB A;  4G8Z X;  1KMS A;  3DL6 A;  2D5N A;  4X5G A;  1YHO A;  3K2H A;  4LAE X;  3FY9 X;  4ELH A;  4ELF A;  3TQB A;  4KL9 A;  3QLS A;  4M7U A;  3Q1H A;  3FQV A;  3FRD X;  1DR5 A;  1ZDR A;  3CSE A;  2OIP A;  3FRE X;  3JSU A;  3EEL A;  1RH3 A;  3D80 A;  4QJC A;  3NXY A;  2CIG A;  1JUV A;  1J3K A;  1RX3 A;  5U27 A;  3NU0 A;  3JW3 A;  3NXO A;  1DRA A;  4IXE D;  4KY4 A;  3JWM A;  3K47 A;  1CD2 A;  4KYA A;  3SRW X;  3SRR X;  1DR1 A;  3N0H A;  3QLW A;  3NXV A;  3QLY A;  3JWF A;  3CD2 A;  4IXF X;  4LEK X;  3NXT A;  5DFR A;  4QJZ D;  3DFR A;  3IRO A;  1BOZ A;  2W9S A;  4CD2 A;  1DG7 A;  1RX7 A;  2INQ A;  4H97 A;  2FZI A;  2P4G A;  1DF7 A;  3K45 A;  1S3U A;  4M6L A;  1J3J A;  3FL9 A;  4FGH A;  4Q0E A;  1DLR A;  1RB3 A;  4P3Q A;  4FHB A;  1LY4 A;  4QHV A;  1DG5 A;  4TU5 X;  5E8Q A;  4H98 A;  1RX5 A;  1DRF A;  3JWK A;  3QLZ A;  3K74 A;  2L28 A;  1IA2 A;  4PSY A;  3S3V A;  3NTZ A;  3F0V X;  3OCH A;  4XEC X;  4QLF A;  1AO8 A;  3HBB A;  2W3V A;  4G3M A;  3NRR A;  4XRB A;  2ANQ A;  7DFR A;  3FL8 A;  4IXG X;  4Q6A A;  1DR6 A;  3UM5 A;  5HI6 A;  5HSU A;  2ITH A;  1S3W A;  2B3Z A;  1RA3 A;  2ANO A;  3LG4 A;  4KLX A;  3TQA A;  1DYH A;  5HUI A;  4Q0D A;  3KY8 A;  1RC4 A;  4HA9 A;  1PD9 A;  2G6V A;  4X5J A;  5HPB A;  4RGC A;  5JA3 A;  2QK8 A;  1M78 A;  3KGY A;  1S3Y A;  3QG2 A;  3QGT A;  3SRQ X;  4KEB A;  5HSR A;  3CLB A;  1DYJ A;  3VCO A;  1DDR A;  3GHW A;  3TD8 A;  4ELE A;  4P68 A;  3KFY A;  3NZ9 X;  3GI2 A;  5JG0 X;  4X5F A;  4DPD A;  3JTW A;  3JW5 A;  1IA4 A;  1MVT A;  2JYB A;  4XT5 A;  3QYL A;  5HVE A;  4X5I A;  1DHI A;  1DG8 A;  4G95 A;  6DFR A;  3SA2 A;  3RG9 A;  4HOF A;  3ZPC A;  1RA1 A;  3SRU X;  3DGA A;  3FY8 X;  3IX9 A;  3F8Y A;  1DYR A;  1DIS A;  4KM0 A;  4KAK A;  2AZN A;  2LF1 A;  4Q67 A;  3F0Q X;  3DAT A;  2C2S A;  1DRE A;  3QFX A;  3M08 A;  4EJ1 A;  3F0U X;  1DYI A;  4I1N A;  5HF2 X;  4KJL A;  1DR3 A;  4M6J A;  3EEM A;  2BLA A;  4KFJ A;  3SA1 A;  1RB2 A;  2W3M A;  4HOE A;  4PSS A;  1RX1 A;  3FRA X;  5HT5 A;  4H95 A;  4M6K A;  1JOM A;  2BLC A;  4XT8 A;  1OHK A;  3QL0 A;  4PDJ A;  3ZPG A;  1HFR A;  4EIL A;  3HJ3 A;  5FDA A;  1HFP A;  1DAJ A;  2C2T A;  1RA8 A;  2D0K A;  1RD7 A;  3FYV X;  3JVX A;  5HVB A;  4QLE A;  3M09 A;  5CCC A;  3F0X X;  3EX8 A;  1KLK A;  1DR4 A;  4KJJ A;  3IRM A;  3L3R A;  4KJK A;  1OHJ A;  3CL9 A;  2XW7 A;  4KY8 A;  4OR7 A;  3IRN A;  3SRS X;  3FQZ A;  3ROA A;  2H2Q A;  4OSG A;  4GH8 A;  4PTH A;  1D1G A;  3FS6 A;  4FGG A;  3INV A;  3JWC A;  3EEJ A;  2CD2 A;  1RA9 A;  1KMV A;  4HOG A;  4QLG A;  4DP3 A;  4DFR A;  4KNE A;  4X5H A;  3EIG A;  1RA2 A;  3UM8 A;  3FQO A;  4KBN A;  4XE6 X;  1VDR A;  3S7A A;  1RX8 A;  4I13 A;  3SQY X;  4PST A;  3FYW X;  1U72 A;  2FZH A;  5DXV A;  5HQY A;  3NZ6 X;  3NZD A;  3S9U A;  4EIG A;  3QL3 A;  3NZA X;  3NZC X;  4M2X A;  1RX6 A;  4XT7 A;  3DL5 A;  3FQF A;  1RX9 A;  4HA7 A;  4DDR A;  4ECK A;  2HM9 A;  1DR2 A;  1U71 A;  4LAH X;  1DDS A;  1U70 A;  4LAG X;  1AOE A;  3SGY A;  1PDB A;  4M7V A;  1IA3 A;  1BZF A;  3EEK A;  1E26 A;  1RX2 A;  3SAI A;  3I8A X;  1AI9 A;  3R33 A;  4QI9 A;  1DHF A;  2W3A A;  4NX6 A;  1LUD A;  1S3V A;  4ELG A;  2BL9 A;  1CZ3 A;  4KD7 A;  4P66 A;  3F8Z A;  4NX7 A;  3NXX A;  3IA4 A;  3OAF A;  1QZF A; 
#chains in the Genus database with same CATH homology
 2BLB A;  1RG7 A;  1HFQ A;  1DIU A;  5EAJ A;  3FQ0 A;  2HQP A;  4PTJ A;  4DPH A;  4XT4 A;  2W3B A;  3DAU A;  1TDR A;  3GYF A;  1SEJ A;  8DFR A;  3TQ8 A;  2DRC A;  3RO9 A;  2GD9 A;  1M79 A;  4KM2 A;  2OBC A;  3QLR A;  3GHC A;  1PD8 A;  3QLX A;  5HF0 X;  5U26 A;  1RX4 A;  2W9H A;  1VJ3 A;  1DRH A;  1LY3 A;  1IA1 A;  5HQZ A;  1RE7 A;  2HXV A;  3GHV A;  2W9G A;  5ECX A;  5ECC A;  3DRC A;  3DG8 A;  3KJR A;  3F0B X;  1JOL A;  3FQC A;  1DLS A;  3E0B A;  1RF7 A;  2FZJ A;  4EIZ A;  3FRB X;  3D84 X;  4H96 A;  1M7A A;  3NZB X;  3SH2 A;  3F91 A;  3KJS A;  3IA5 A;  3TQ9 A;  2W3W A;  1J3I A;  3UM6 A;  4P3R A;  4XT6 A;  3QYO A;  5CC9 A;  3I3R A;  1DHJ A;  2KGK A;  3NXR A;  1MVS A;  3F0S X;  4ELB A;  2ZZA A;  3SR5 X;  2DHF A;  5HT4 A;  1DR7 A;  2W9T A;  3FRF X;  2O7P A;  1DRB A;  4G8Z X;  1KMS A;  3DL6 A;  2D5N A;  4X5G A;  1YHO A;  3K2H A;  4LAE X;  3FY9 X;  4ELH A;  4ELF A;  3TQB A;  4KL9 A;  3QLS A;  4M7U A;  3Q1H A;  3FQV A;  3FRD X;  1DR5 A;  1ZDR A;  3CSE A;  2OIP A;  3FRE X;  3JSU A;  3EEL A;  1RH3 A;  3D80 A;  4QJC A;  3NXY A;  2CIG A;  1JUV A;  1J3K A;  1RX3 A;  5U27 A;  3NU0 A;  3JW3 A;  3NXO A;  1DRA A;  4IXE D;  4KY4 A;  3JWM A;  3K47 A;  1CD2 A;  4KYA A;  3SRW X;  3SRR X;  1DR1 A;  3N0H A;  3QLW A;  3NXV A;  3QLY A;  3JWF A;  3CD2 A;  4IXF X;  4LEK X;  3NXT A;  5DFR A;  4QJZ D;  3DFR A;  3IRO A;  1BOZ A;  2W9S A;  4CD2 A;  1DG7 A;  1RX7 A;  2INQ A;  4H97 A;  2FZI A;  2P4G A;  1DF7 A;  3K45 A;  1S3U A;  4M6L A;  1J3J A;  3FL9 A;  4FGH A;  4Q0E A;  1DLR A;  1RB3 A;  4P3Q A;  4FHB A;  1LY4 A;  4QHV A;  1DG5 A;  4TU5 X;  5E8Q A;  4H98 A;  1RX5 A;  1DRF A;  3JWK A;  3QLZ A;  3K74 A;  2L28 A;  1IA2 A;  4PSY A;  3S3V A;  3NTZ A;  3F0V X;  3OCH A;  4XEC X;  4QLF A;  1AO8 A;  3HBB A;  2W3V A;  4G3M A;  3NRR A;  4XRB A;  2ANQ A;  7DFR A;  3FL8 A;  4IXG X;  4Q6A A;  1DR6 A;  3UM5 A;  5HI6 A;  5HSU A;  2ITH A;  1S3W A;  2B3Z A;  1RA3 A;  2ANO A;  3LG4 A;  4KLX A;  3TQA A;  1DYH A;  5HUI A;  4Q0D A;  3KY8 A;  1RC4 A;  4HA9 A;  1PD9 A;  2G6V A;  4X5J A;  5HPB A;  4RGC A;  5JA3 A;  2QK8 A;  1M78 A;  3KGY A;  1S3Y A;  3QG2 A;  3QGT A;  3SRQ X;  4KEB A;  5HSR A;  3CLB A;  1DYJ A;  3VCO A;  1DDR A;  3GHW A;  3TD8 A;  4ELE A;  4P68 A;  3KFY A;  3NZ9 X;  3GI2 A;  5JG0 X;  4X5F A;  4DPD A;  3JTW A;  3JW5 A;  1IA4 A;  1MVT A;  2JYB A;  4XT5 A;  3QYL A;  5HVE A;  4X5I A;  1DHI A;  1DG8 A;  4G95 A;  6DFR A;  3SA2 A;  3RG9 A;  4HOF A;  3ZPC A;  1RA1 A;  3SRU X;  3DGA A;  3FY8 X;  3IX9 A;  3F8Y A;  1DYR A;  1DIS A;  4KM0 A;  4KAK A;  2AZN A;  2LF1 A;  4Q67 A;  3F0Q X;  3DAT A;  2C2S A;  1DRE A;  3QFX A;  3M08 A;  4EJ1 A;  3F0U X;  1DYI A;  4I1N A;  5HF2 X;  4KJL A;  1DR3 A;  4M6J A;  3EEM A;  2BLA A;  4KFJ A;  3SA1 A;  1RB2 A;  2W3M A;  4HOE A;  4PSS A;  1RX1 A;  3FRA X;  5HT5 A;  4H95 A;  4M6K A;  1JOM A;  2BLC A;  4XT8 A;  1OHK A;  3QL0 A;  4PDJ A;  3ZPG A;  1HFR A;  4EIL A;  3HJ3 A;  5FDA A;  1HFP A;  1DAJ A;  2C2T A;  1RA8 A;  2D0K A;  1RD7 A;  3FYV X;  3JVX A;  5HVB A;  4QLE A;  3M09 A;  5CCC A;  3F0X X;  3EX8 A;  1KLK A;  1DR4 A;  4KJJ A;  3IRM A;  3L3R A;  4KJK A;  1OHJ A;  3CL9 A;  2XW7 A;  4KY8 A;  4OR7 A;  3IRN A;  3SRS X;  3FQZ A;  3ROA A;  2H2Q A;  4OSG A;  4GH8 A;  4PTH A;  1D1G A;  3FS6 A;  4FGG A;  3INV A;  3JWC A;  3EEJ A;  2CD2 A;  1RA9 A;  1KMV A;  4HOG A;  4QLG A;  4DP3 A;  4DFR A;  4KNE A;  4X5H A;  3EIG A;  1RA2 A;  3UM8 A;  3FQO A;  4KBN A;  4XE6 X;  1VDR A;  3S7A A;  1RX8 A;  4I13 A;  3SQY X;  4PST A;  3FYW X;  1U72 A;  2FZH A;  5DXV A;  5HQY A;  3NZ6 X;  3NZD A;  3S9U A;  4EIG A;  3QL3 A;  3NZA X;  3NZC X;  4M2X A;  1RX6 A;  4XT7 A;  3DL5 A;  3FQF A;  1RX9 A;  4HA7 A;  4DDR A;  4ECK A;  2HM9 A;  1DR2 A;  1U71 A;  4LAH X;  1DDS A;  1U70 A;  4LAG X;  1AOE A;  3SGY A;  1PDB A;  4M7V A;  1IA3 A;  1BZF A;  3EEK A;  1E26 A;  1RX2 A;  3SAI A;  3I8A X;  1AI9 A;  3R33 A;  4QI9 A;  1DHF A;  2W3A A;  4NX6 A;  1LUD A;  1S3V A;  4ELG A;  2BL9 A;  1CZ3 A;  4KD7 A;  4P66 A;  3F8Z A;  4NX7 A;  3NXX A;  3IA4 A;  3OAF A;  1QZF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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