3QFXA

Trypanosoma brucei dihydrofolate reductase pyrimethamine complex
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
219
structure length
219
Chain Sequence
RPPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFFDIPAAGTKTPEGLELVRESITDERVSTGAGGKKYQFEKLVPRNS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Trypanosomal dihydrofolate reductase reveals natural antifolate resistance
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Trypanosoma brucei rhodesiense
molecule keywords Bifunctional dihydrofolate reductase-thymidylate synthase
total genus 58
structure length 219
sequence length 219
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2011-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3qfxA00
1RX7A 3FQ0A 3I3RA 4X5IA 1DRHA 4ELEA 4KY8A 1DLRA 5ECCA 3F91A 3NXYA 4ELBA 4EJ1A 2C2TA 1IA3A 2FZIA 2HQPA 4H95A 3SRRX 3S9UA 3M08A 1DREA 4DPDA 6DFRA 4GH8A 4KYAA 3JWFA 4H97A 3OAFA 4EIGA 1S3WA 3NZDA 3D80A 4IXGX 4HOFA 1RX3A 4QHVA 4FGGA 4PDJA 2BL9A 4DPHA 3FRBX 1S3YA 5HT4A 3FYWX 4Q6AA 4LAHX 3SRWX 3SRSX 3JWMA 4KNEA 4PTHA 4P3RA 1RX1A 4KFJA 5CCCA 3FREX 3K2HA 1RD7A 3R33A 1KMSA 4QI9A 3EEKA 3UM5A 1SEJA 3FS6A 5FDAA 3FRFX 4P66A 1RC4A 4KJKA 3QLRA 2INQA 3K45A 2DRCA 5HF0X 1RX2A 3NTZA 3SA1A 3IROA 2W9SA 4DFRA 3QLSA 5HVEA 1RF7A 3JWKA 3FL9A 5DFRA 3NU0A 2HXVA 3SRUX 1JOMA 2ANOA 3CLBA 3FQCA 1MVTA 2W9TA 1JOLA 3GHVA 3ZPGA 3JVXA 3NXTA 3SR5X 4KEBA 3IX9A 4I13A 2C2SA 3CL9A 4XE6X 2W9HA 2JYBA 4QLFA 1VJ3A 5EAJA 3M09A 4X5FA 3FY9X 3FQVA 1DIUA 4DP3A 3JTWA 3SGYA 3FQZA 5HT5A 3QLWA 2B3ZA 4XT5A 5HUIA 3DGAA 1M7AA 3NRRA 3GYFA 2QK8A 1J3JA 2W3AA 2AZNA 2FZJA 4Q0DA 3NZBX 2GD9A 3EELA 3RO9A 4KM0A 3KY8A 1DR6A 3DG8A 4XT8A 2KGKA 3FQFA 2L28A 1CD2A 1RE7A 3NZCX 4M7UA 4OSGA 4ELHA 4KAKA 2BLAA 1MVSA 3F0BX 3LG4A 4G95A 3KJRA 1RX5A 4HOEA 1YHOA 5ECXA 1M78A 1RA8A 3GHCA 4Q0EA 1DHFA 4ELFA 1RX8A 4M6KA 3QL0A 1LUDA 3QLYA 3DRCA 3GHWA 2W3BA 2W9GA 3NZ9X 3IA5A 1DG5A 4P3QA 2XW7A 3QYLA 2ANQA 4NX6A 4TU5X 4EIZA 1RB3A 3Q1HA 3JW3A 3FL8A 4RGCA 3SQYX 1DG7A 1DR4A 3KFYA 3IRNA 1OHKA 3FRAX 4KM2A 3FY8X 3QYOA 3SAIA 1J3KA 1LY4A 3SH2A 2CIGA 1DRBA 3QGTA 1VDRA 3FRDX 4ECKA 2H2QA 3NZ6X 1DHIA 5HQZA 3TD8A 3KGYA 3NXRA 3F0QX 5JG0X 1LY3A 4HOGA 3FQOA 5DXVA 2P4GA 1IA1A 1DYRA 3L3RA 3CSEA 1RA3A 3JW5A 3ROAA 3INVA 3SA2A 3EEMA 1CZ3A 3UM6A 4QJCA 1IA2A 3F0UX 1DR2A 4NX7A 3I8AX 3TQBA 5HSUA 3JSUA 2D0KA 3QL3A 1DF7A 5U26A 3TQ9A 2O7PA 3F0VX 3NXVA 1RA9A 1BOZA 3DL6A 1OHJA 1KLKA 1S3UA 2HM9A 3D84X 3NXXA 1DR3A 2OIPA 4M6LA 3KJSA 3K47A 2CD2A 4KD7A 4I1NA 3IRMA 4PTJA 2DHFA 4DDRA 1HFRA 4KY4A 4LAEX 4FHBA 1RA2A 4M2XA 3F0XX 5JA3A 2BLCA 1DYJA 4KJJA 1TDRA 3EX8A 3UM8A 3NZAX 1DISA 5HVBA 4QLEA 1PD8A 2OBCA 3QLZA 1S3VA 1KMVA 5HQYA 1U72A 1RG7A 4H98A 3IA4A 1DDRA 4QLGA 1M79A 1DYIA 1DDSA 1DR1A 3RG9A 4LAGX 4Q67A 3DL5A 3E0BA 4M7VA 3JWCA 3SRQX 1DRAA 4PSSA 3F8ZA 1RX6A 4PSYA 2D5NA 1DYHA 4X5GA 4XRBA 4FGHA 7DFRA 2W3MA 1RX9A 1HFPA 4X5HA 1AOEA 5U27A 1BZFA 3S3VA 4XT4A 3DFRA 5HPBA 3EEJA 1U71A 5HSRA 4KL9A 1DR7A 1RB2A 4LEKX 3QG2A 3OCHA 3HBBA 2W3WA 3VCOA 4IXED 4KJLA 3ZPCA 4PSTA 4KLXA 1PDBA 3QLXA 1AI9A 3TQAA 2LF1A 3K74A 5E8QA 1D1GA 3DAUA 1U70A 1DLSA 4CD2A 4HA9A 4H96A 4IXFX 1DG8A 1DAJA 1QZFA 4P68A 1J3IA 4X5JA 2BLBA 2ZZAA 4OR7A 1RA1A 1HFQA 4KBNA 3NXOA 3CD2A 3EIGA 3F0SX 3FYVX 4QJZD 4HA7A 1RX4A 4G3MA 1E26A 1DHJA 1DRFA 2ITHA 4XT7A 3TQ8A 1JUVA 2FZHA 4EILA 2W3VA 4XECX 4XT6A 1IA4A 1RH3A 5CC9A 3GI2A 3QFXA 4ELGA 3HJ3A 3F8YA 3N0HA 2G6VA 8DFRA 1AO8A 5HI6A 3DATA 1ZDRA 1DR5A 3S7AA 1PD9A 5HF2X 4G8ZX 4M6JA
chains in the Genus database with same CATH superfamily
1RX7A 3FQ0A 3I3RA 4X5IA 1DRHA 4ELEA 4KY8A 1DLRA 5ECCA 3F91A 3NXYA 4ELBA 4EJ1A 2C2TA 1IA3A 2FZIA 2HQPA 4H95A 3SRRX 3S9UA 3M08A 1DREA 4DPDA 6DFRA 4GH8A 4KYAA 3JWFA 4H97A 3OAFA 4EIGA 1S3WA 3NZDA 3D80A 4IXGX 4HOFA 1RX3A 4QHVA 4FGGA 4PDJA 2BL9A 4DPHA 3FRBX 1S3YA 5HT4A 3FYWX 4Q6AA 4LAHX 3SRWX 3SRSX 3JWMA 4KNEA 4PTHA 4P3RA 1RX1A 4KFJA 5CCCA 3FREX 3K2HA 1RD7A 3R33A 1KMSA 4QI9A 3EEKA 3UM5A 1SEJA 3FS6A 5FDAA 3FRFX 4P66A 1RC4A 4KJKA 3QLRA 2INQA 3K45A 2DRCA 5HF0X 1RX2A 3NTZA 3SA1A 3IROA 2W9SA 4DFRA 3QLSA 5HVEA 1RF7A 3JWKA 3FL9A 5DFRA 3NU0A 2HXVA 3SRUX 1JOMA 2ANOA 3CLBA 3FQCA 1MVTA 2W9TA 1JOLA 3GHVA 3ZPGA 3JVXA 3NXTA 3SR5X 4KEBA 3IX9A 4I13A 2C2SA 3CL9A 4XE6X 2W9HA 2JYBA 4QLFA 1VJ3A 5EAJA 3M09A 4X5FA 3FY9X 3FQVA 1DIUA 4DP3A 3JTWA 3SGYA 3FQZA 5HT5A 3QLWA 2B3ZA 4XT5A 5HUIA 3DGAA 1M7AA 3NRRA 3GYFA 2QK8A 1J3JA 2W3AA 2AZNA 2FZJA 4Q0DA 3NZBX 2GD9A 3EELA 3RO9A 4KM0A 3KY8A 1DR6A 3DG8A 4XT8A 2KGKA 3FQFA 2L28A 1CD2A 1RE7A 3NZCX 4M7UA 4OSGA 4ELHA 4KAKA 2BLAA 1MVSA 3F0BX 3LG4A 4G95A 3KJRA 1RX5A 4HOEA 1YHOA 5ECXA 1M78A 1RA8A 3GHCA 4Q0EA 1DHFA 4ELFA 1RX8A 4M6KA 3QL0A 1LUDA 3QLYA 3DRCA 3GHWA 2W3BA 2W9GA 3NZ9X 3IA5A 1DG5A 4P3QA 2XW7A 3QYLA 2ANQA 4NX6A 4TU5X 4EIZA 1RB3A 3Q1HA 3JW3A 3FL8A 4RGCA 3SQYX 1DG7A 1DR4A 3KFYA 3IRNA 1OHKA 3FRAX 4KM2A 3FY8X 3QYOA 3SAIA 1J3KA 1LY4A 3SH2A 2CIGA 1DRBA 3QGTA 1VDRA 3FRDX 4ECKA 2H2QA 3NZ6X 1DHIA 5HQZA 3TD8A 3KGYA 3NXRA 3F0QX 5JG0X 1LY3A 4HOGA 3FQOA 5DXVA 2P4GA 1IA1A 1DYRA 3L3RA 3CSEA 1RA3A 3JW5A 3ROAA 3INVA 3SA2A 3EEMA 1CZ3A 3UM6A 4QJCA 1IA2A 3F0UX 1DR2A 4NX7A 3I8AX 3TQBA 5HSUA 3JSUA 2D0KA 3QL3A 1DF7A 5U26A 3TQ9A 2O7PA 3F0VX 3NXVA 1RA9A 1BOZA 3DL6A 1OHJA 1KLKA 1S3UA 2HM9A 3D84X 3NXXA 1DR3A 2OIPA 4M6LA 3KJSA 3K47A 2CD2A 4KD7A 4I1NA 3IRMA 4PTJA 2DHFA 4DDRA 1HFRA 4KY4A 4LAEX 4FHBA 1RA2A 4M2XA 3F0XX 5JA3A 2BLCA 1DYJA 4KJJA 1TDRA 3EX8A 3UM8A 3NZAX 1DISA 5HVBA 4QLEA 1PD8A 2OBCA 3QLZA 1S3VA 1KMVA 5HQYA 1U72A 1RG7A 4H98A 3IA4A 1DDRA 4QLGA 1M79A 1DYIA 1DDSA 1DR1A 3RG9A 4LAGX 4Q67A 3DL5A 3E0BA 4M7VA 3JWCA 3SRQX 1DRAA 4PSSA 3F8ZA 1RX6A 4PSYA 2D5NA 1DYHA 4X5GA 4XRBA 4FGHA 7DFRA 2W3MA 1RX9A 1HFPA 4X5HA 1AOEA 5U27A 1BZFA 3S3VA 4XT4A 3DFRA 5HPBA 3EEJA 1U71A 5HSRA 4KL9A 1DR7A 1RB2A 4LEKX 3QG2A 3OCHA 3HBBA 2W3WA 3VCOA 4IXED 4KJLA 3ZPCA 4PSTA 4KLXA 1PDBA 3QLXA 1AI9A 3TQAA 2LF1A 3K74A 5E8QA 1D1GA 3DAUA 1U70A 1DLSA 4CD2A 4HA9A 4H96A 4IXFX 1DG8A 1DAJA 1QZFA 4P68A 1J3IA 4X5JA 2BLBA 2ZZAA 4OR7A 1RA1A 1HFQA 4KBNA 3NXOA 3CD2A 3EIGA 3F0SX 3FYVX 4QJZD 4HA7A 1RX4A 4G3MA 1E26A 1DHJA 1DRFA 2ITHA 4XT7A 3TQ8A 1JUVA 2FZHA 4EILA 2W3VA 4XECX 4XT6A 1IA4A 1RH3A 5CC9A 3GI2A 3QFXA 4ELGA 3HJ3A 3F8YA 3N0HA 2G6VA 8DFRA 1AO8A 5HI6A 3DATA 1ZDRA 1DR5A 3S7AA 1PD9A 5HF2X 4G8ZX 4M6JA
chains in the Genus database with same CATH topology
1RX7A 3FQ0A 3I3RA 4X5IA 1DRHA 4ELEA 4KY8A 1DLRA 5ECCA 3F91A 3NXYA 4ELBA 4EJ1A 2C2TA 1IA3A 2FZIA 2HQPA 4H95A 3SRRX 3S9UA 3M08A 1DREA 4DPDA 6DFRA 4GH8A 4KYAA 3JWFA 4H97A 3OAFA 4EIGA 1S3WA 3NZDA 3D80A 4IXGX 4HOFA 1RX3A 4QHVA 4FGGA 4PDJA 2BL9A 4DPHA 3FRBX 1S3YA 5HT4A 3FYWX 4Q6AA 4LAHX 3SRWX 3SRSX 3JWMA 4KNEA 4PTHA 4P3RA 1RX1A 4KFJA 5CCCA 3FREX 3K2HA 1RD7A 3R33A 1KMSA 4QI9A 3EEKA 3UM5A 1SEJA 3FS6A 5FDAA 3FRFX 4P66A 1RC4A 4KJKA 3QLRA 2INQA 3K45A 2DRCA 5HF0X 1RX2A 3NTZA 3SA1A 3IROA 2W9SA 4DFRA 3QLSA 5HVEA 1RF7A 3JWKA 3FL9A 5DFRA 3NU0A 2HXVA 3SRUX 1JOMA 2ANOA 3CLBA 3FQCA 1MVTA 2W9TA 1JOLA 3GHVA 3ZPGA 3JVXA 3NXTA 3SR5X 4KEBA 3IX9A 4I13A 2C2SA 3CL9A 4XE6X 2W9HA 2JYBA 4QLFA 1VJ3A 5EAJA 3M09A 4X5FA 3FY9X 3FQVA 1DIUA 4DP3A 3JTWA 3SGYA 3FQZA 5HT5A 3QLWA 2B3ZA 4XT5A 5HUIA 3DGAA 1M7AA 3NRRA 3GYFA 2QK8A 1J3JA 2W3AA 2AZNA 2FZJA 4Q0DA 3NZBX 2GD9A 3EELA 3RO9A 4KM0A 3KY8A 1DR6A 3DG8A 4XT8A 2KGKA 3FQFA 2L28A 1CD2A 1RE7A 3NZCX 4M7UA 4OSGA 4ELHA 4KAKA 2BLAA 1MVSA 3F0BX 3LG4A 4G95A 3KJRA 1RX5A 4HOEA 1YHOA 5ECXA 1M78A 1RA8A 3GHCA 4Q0EA 1DHFA 4ELFA 1RX8A 4M6KA 3QL0A 1LUDA 3QLYA 3DRCA 3GHWA 2W3BA 2W9GA 3NZ9X 3IA5A 1DG5A 4P3QA 2XW7A 3QYLA 2ANQA 4NX6A 4TU5X 4EIZA 1RB3A 3Q1HA 3JW3A 3FL8A 4RGCA 3SQYX 1DG7A 1DR4A 3KFYA 3IRNA 1OHKA 3FRAX 4KM2A 3FY8X 3QYOA 3SAIA 1J3KA 1LY4A 3SH2A 2CIGA 1DRBA 3QGTA 1VDRA 3FRDX 4ECKA 2H2QA 3NZ6X 1DHIA 5HQZA 3TD8A 3KGYA 3NXRA 3F0QX 5JG0X 1LY3A 4HOGA 3FQOA 5DXVA 2P4GA 1IA1A 1DYRA 3L3RA 3CSEA 1RA3A 3JW5A 3ROAA 3INVA 3SA2A 3EEMA 1CZ3A 3UM6A 4QJCA 1IA2A 3F0UX 1DR2A 4NX7A 3I8AX 3TQBA 5HSUA 3JSUA 2D0KA 3QL3A 1DF7A 5U26A 3TQ9A 2O7PA 3F0VX 3NXVA 1RA9A 1BOZA 3DL6A 1OHJA 1KLKA 1S3UA 2HM9A 3D84X 3NXXA 1DR3A 2OIPA 4M6LA 3KJSA 3K47A 2CD2A 4KD7A 4I1NA 3IRMA 4PTJA 2DHFA 4DDRA 1HFRA 4KY4A 4LAEX 4FHBA 1RA2A 4M2XA 3F0XX 5JA3A 2BLCA 1DYJA 4KJJA 1TDRA 3EX8A 3UM8A 3NZAX 1DISA 5HVBA 4QLEA 1PD8A 2OBCA 3QLZA 1S3VA 1KMVA 5HQYA 1U72A 1RG7A 4H98A 3IA4A 1DDRA 4QLGA 1M79A 1DYIA 1DDSA 1DR1A 3RG9A 4LAGX 4Q67A 3DL5A 3E0BA 4M7VA 3JWCA 3SRQX 1DRAA 4PSSA 3F8ZA 1RX6A 4PSYA 2D5NA 1DYHA 4X5GA 4XRBA 4FGHA 7DFRA 2W3MA 1RX9A 1HFPA 4X5HA 1AOEA 5U27A 1BZFA 3S3VA 4XT4A 3DFRA 5HPBA 3EEJA 1U71A 5HSRA 4KL9A 1DR7A 1RB2A 4LEKX 3QG2A 3OCHA 3HBBA 2W3WA 3VCOA 4IXED 4KJLA 3ZPCA 4PSTA 4KLXA 1PDBA 3QLXA 1AI9A 3TQAA 2LF1A 3K74A 5E8QA 1D1GA 3DAUA 1U70A 1DLSA 4CD2A 4HA9A 4H96A 4IXFX 1DG8A 1DAJA 1QZFA 4P68A 1J3IA 4X5JA 2BLBA 2ZZAA 4OR7A 1RA1A 1HFQA 4KBNA 3NXOA 3CD2A 3EIGA 3F0SX 3FYVX 4QJZD 4HA7A 1RX4A 4G3MA 1E26A 1DHJA 1DRFA 2ITHA 4XT7A 3TQ8A 1JUVA 2FZHA 4EILA 2W3VA 4XECX 4XT6A 1IA4A 1RH3A 5CC9A 3GI2A 3QFXA 4ELGA 3HJ3A 3F8YA 3N0HA 2G6VA 8DFRA 1AO8A 5HI6A 3DATA 1ZDRA 1DR5A 3S7AA 1PD9A 5HF2X 4G8ZX 4M6JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RX7 A;  3FQ0 A;  3I3R A;  4X5I A;  1DRH A;  4ELE A;  4KY8 A;  1DLR A;  5ECC A;  3F91 A;  3NXY A;  4ELB A;  4EJ1 A;  2C2T A;  1IA3 A;  2FZI A;  2HQP A;  4H95 A;  3SRR X;  3S9U A;  3M08 A;  1DRE A;  4DPD A;  6DFR A;  4GH8 A;  4KYA A;  3JWF A;  4H97 A;  3OAF A;  4EIG A;  1S3W A;  3NZD A;  3D80 A;  4IXG X;  4HOF A;  1RX3 A;  4QHV A;  4FGG A;  4PDJ A;  2BL9 A;  4DPH A;  3FRB X;  1S3Y A;  5HT4 A;  3FYW X;  4Q6A A;  4LAH X;  3SRW X;  3SRS X;  3JWM A;  4KNE A;  4PTH A;  4P3R A;  1RX1 A;  4KFJ A;  5CCC A;  3FRE X;  3K2H A;  1RD7 A;  3R33 A;  1KMS A;  4QI9 A;  3EEK A;  3UM5 A;  1SEJ A;  3FS6 A;  5FDA A;  3FRF X;  4P66 A;  1RC4 A;  4KJK A;  3QLR A;  2INQ A;  3K45 A;  2DRC A;  5HF0 X;  1RX2 A;  3NTZ A;  3SA1 A;  3IRO A;  2W9S A;  4DFR A;  3QLS A;  5HVE A;  1RF7 A;  3JWK A;  3FL9 A;  5DFR A;  3NU0 A;  2HXV A;  3SRU X;  1JOM A;  2ANO A;  3CLB A;  3FQC A;  1MVT A;  2W9T A;  1JOL A;  3GHV A;  3ZPG A;  3JVX A;  3NXT A;  3SR5 X;  4KEB A;  3IX9 A;  4I13 A;  2C2S A;  3CL9 A;  4XE6 X;  2W9H A;  2JYB A;  4QLF A;  1VJ3 A;  5EAJ A;  3M09 A;  4X5F A;  3FY9 X;  3FQV A;  1DIU A;  4DP3 A;  3JTW A;  3SGY A;  3FQZ A;  5HT5 A;  3QLW A;  2B3Z A;  4XT5 A;  5HUI A;  3DGA A;  1M7A A;  3NRR A;  3GYF A;  2QK8 A;  1J3J A;  2W3A A;  2AZN A;  2FZJ A;  4Q0D A;  3NZB X;  2GD9 A;  3EEL A;  3RO9 A;  4KM0 A;  3KY8 A;  1DR6 A;  3DG8 A;  4XT8 A;  2KGK A;  3FQF A;  2L28 A;  1CD2 A;  1RE7 A;  3NZC X;  4M7U A;  4OSG A;  4ELH A;  4KAK A;  2BLA A;  1MVS A;  3F0B X;  3LG4 A;  4G95 A;  3KJR A;  1RX5 A;  4HOE A;  1YHO A;  5ECX A;  1M78 A;  1RA8 A;  3GHC A;  4Q0E A;  1DHF A;  4ELF A;  1RX8 A;  4M6K A;  3QL0 A;  1LUD A;  3QLY A;  3DRC A;  3GHW A;  2W3B A;  2W9G A;  3NZ9 X;  3IA5 A;  1DG5 A;  4P3Q A;  2XW7 A;  3QYL A;  2ANQ A;  4NX6 A;  4TU5 X;  4EIZ A;  1RB3 A;  3Q1H A;  3JW3 A;  3FL8 A;  4RGC A;  3SQY X;  1DG7 A;  1DR4 A;  3KFY A;  3IRN A;  1OHK A;  3FRA X;  4KM2 A;  3FY8 X;  3QYO A;  3SAI A;  1J3K A;  1LY4 A;  3SH2 A;  2CIG A;  1DRB A;  3QGT A;  1VDR A;  3FRD X;  4ECK A;  2H2Q A;  3NZ6 X;  1DHI A;  5HQZ A;  3TD8 A;  3KGY A;  3NXR A;  3F0Q X;  5JG0 X;  1LY3 A;  4HOG A;  3FQO A;  5DXV A;  2P4G A;  1IA1 A;  1DYR A;  3L3R A;  3CSE A;  1RA3 A;  3JW5 A;  3ROA A;  3INV A;  3SA2 A;  3EEM A;  1CZ3 A;  3UM6 A;  4QJC A;  1IA2 A;  3F0U X;  1DR2 A;  4NX7 A;  3I8A X;  3TQB A;  5HSU A;  3JSU A;  2D0K A;  3QL3 A;  1DF7 A;  5U26 A;  3TQ9 A;  2O7P A;  3F0V X;  3NXV A;  1RA9 A;  1BOZ A;  3DL6 A;  1OHJ A;  1KLK A;  1S3U A;  2HM9 A;  3D84 X;  3NXX A;  1DR3 A;  2OIP A;  4M6L A;  3KJS A;  3K47 A;  2CD2 A;  4KD7 A;  4I1N A;  3IRM A;  4PTJ A;  2DHF A;  4DDR A;  1HFR A;  4KY4 A;  4LAE X;  4FHB A;  1RA2 A;  4M2X A;  3F0X X;  5JA3 A;  2BLC A;  1DYJ A;  4KJJ A;  1TDR A;  3EX8 A;  3UM8 A;  3NZA X;  1DIS A;  5HVB A;  4QLE A;  1PD8 A;  2OBC A;  3QLZ A;  1S3V A;  1KMV A;  5HQY A;  1U72 A;  1RG7 A;  4H98 A;  3IA4 A;  1DDR A;  4QLG A;  1M79 A;  1DYI A;  1DDS A;  1DR1 A;  3RG9 A;  4LAG X;  4Q67 A;  3DL5 A;  3E0B A;  4M7V A;  3JWC A;  3SRQ X;  1DRA A;  4PSS A;  3F8Z A;  1RX6 A;  4PSY A;  2D5N A;  1DYH A;  4X5G A;  4XRB A;  4FGH A;  7DFR A;  2W3M A;  1RX9 A;  1HFP A;  4X5H A;  1AOE A;  5U27 A;  1BZF A;  3S3V A;  4XT4 A;  3DFR A;  5HPB A;  3EEJ A;  1U71 A;  5HSR A;  4KL9 A;  1DR7 A;  1RB2 A;  4LEK X;  3QG2 A;  3OCH A;  3HBB A;  2W3W A;  3VCO A;  4IXE D;  4KJL A;  3ZPC A;  4PST A;  4KLX A;  1PDB A;  3QLX A;  1AI9 A;  3TQA A;  2LF1 A;  3K74 A;  5E8Q A;  1D1G A;  3DAU A;  1U70 A;  1DLS A;  4CD2 A;  4HA9 A;  4H96 A;  4IXF X;  1DG8 A;  1DAJ A;  1QZF A;  4P68 A;  1J3I A;  4X5J A;  2BLB A;  2ZZA A;  4OR7 A;  1RA1 A;  1HFQ A;  4KBN A;  3NXO A;  3CD2 A;  3EIG A;  3F0S X;  3FYV X;  4QJZ D;  4HA7 A;  1RX4 A;  4G3M A;  1E26 A;  1DHJ A;  1DRF A;  2ITH A;  4XT7 A;  3TQ8 A;  1JUV A;  2FZH A;  4EIL A;  2W3V A;  4XEC X;  4XT6 A;  1IA4 A;  1RH3 A;  5CC9 A;  3GI2 A;  3QFX A;  4ELG A;  3HJ3 A;  3F8Y A;  3N0H A;  2G6V A;  8DFR A;  1AO8 A;  5HI6 A;  3DAT A;  1ZDR A;  1DR5 A;  3S7A A;  1PD9 A;  5HF2 X;  4G8Z X;  4M6J A; 
#chains in the Genus database with same CATH topology
 1RX7 A;  3FQ0 A;  3I3R A;  4X5I A;  1DRH A;  4ELE A;  4KY8 A;  1DLR A;  5ECC A;  3F91 A;  3NXY A;  4ELB A;  4EJ1 A;  2C2T A;  1IA3 A;  2FZI A;  2HQP A;  4H95 A;  3SRR X;  3S9U A;  3M08 A;  1DRE A;  4DPD A;  6DFR A;  4GH8 A;  4KYA A;  3JWF A;  4H97 A;  3OAF A;  4EIG A;  1S3W A;  3NZD A;  3D80 A;  4IXG X;  4HOF A;  1RX3 A;  4QHV A;  4FGG A;  4PDJ A;  2BL9 A;  4DPH A;  3FRB X;  1S3Y A;  5HT4 A;  3FYW X;  4Q6A A;  4LAH X;  3SRW X;  3SRS X;  3JWM A;  4KNE A;  4PTH A;  4P3R A;  1RX1 A;  4KFJ A;  5CCC A;  3FRE X;  3K2H A;  1RD7 A;  3R33 A;  1KMS A;  4QI9 A;  3EEK A;  3UM5 A;  1SEJ A;  3FS6 A;  5FDA A;  3FRF X;  4P66 A;  1RC4 A;  4KJK A;  3QLR A;  2INQ A;  3K45 A;  2DRC A;  5HF0 X;  1RX2 A;  3NTZ A;  3SA1 A;  3IRO A;  2W9S A;  4DFR A;  3QLS A;  5HVE A;  1RF7 A;  3JWK A;  3FL9 A;  5DFR A;  3NU0 A;  2HXV A;  3SRU X;  1JOM A;  2ANO A;  3CLB A;  3FQC A;  1MVT A;  2W9T A;  1JOL A;  3GHV A;  3ZPG A;  3JVX A;  3NXT A;  3SR5 X;  4KEB A;  3IX9 A;  4I13 A;  2C2S A;  3CL9 A;  4XE6 X;  2W9H A;  2JYB A;  4QLF A;  1VJ3 A;  5EAJ A;  3M09 A;  4X5F A;  3FY9 X;  3FQV A;  1DIU A;  4DP3 A;  3JTW A;  3SGY A;  3FQZ A;  5HT5 A;  3QLW A;  2B3Z A;  4XT5 A;  5HUI A;  3DGA A;  1M7A A;  3NRR A;  3GYF A;  2QK8 A;  1J3J A;  2W3A A;  2AZN A;  2FZJ A;  4Q0D A;  3NZB X;  2GD9 A;  3EEL A;  3RO9 A;  4KM0 A;  3KY8 A;  1DR6 A;  3DG8 A;  4XT8 A;  2KGK A;  3FQF A;  2L28 A;  1CD2 A;  1RE7 A;  3NZC X;  4M7U A;  4OSG A;  4ELH A;  4KAK A;  2BLA A;  1MVS A;  3F0B X;  3LG4 A;  4G95 A;  3KJR A;  1RX5 A;  4HOE A;  1YHO A;  5ECX A;  1M78 A;  1RA8 A;  3GHC A;  4Q0E A;  1DHF A;  4ELF A;  1RX8 A;  4M6K A;  3QL0 A;  1LUD A;  3QLY A;  3DRC A;  3GHW A;  2W3B A;  2W9G A;  3NZ9 X;  3IA5 A;  1DG5 A;  4P3Q A;  2XW7 A;  3QYL A;  2ANQ A;  4NX6 A;  4TU5 X;  4EIZ A;  1RB3 A;  3Q1H A;  3JW3 A;  3FL8 A;  4RGC A;  3SQY X;  1DG7 A;  1DR4 A;  3KFY A;  3IRN A;  1OHK A;  3FRA X;  4KM2 A;  3FY8 X;  3QYO A;  3SAI A;  1J3K A;  1LY4 A;  3SH2 A;  2CIG A;  1DRB A;  3QGT A;  1VDR A;  3FRD X;  4ECK A;  2H2Q A;  3NZ6 X;  1DHI A;  5HQZ A;  3TD8 A;  3KGY A;  3NXR A;  3F0Q X;  5JG0 X;  1LY3 A;  4HOG A;  3FQO A;  5DXV A;  2P4G A;  1IA1 A;  1DYR A;  3L3R A;  3CSE A;  1RA3 A;  3JW5 A;  3ROA A;  3INV A;  3SA2 A;  3EEM A;  1CZ3 A;  3UM6 A;  4QJC A;  1IA2 A;  3F0U X;  1DR2 A;  4NX7 A;  3I8A X;  3TQB A;  5HSU A;  3JSU A;  2D0K A;  3QL3 A;  1DF7 A;  5U26 A;  3TQ9 A;  2O7P A;  3F0V X;  3NXV A;  1RA9 A;  1BOZ A;  3DL6 A;  1OHJ A;  1KLK A;  1S3U A;  2HM9 A;  3D84 X;  3NXX A;  1DR3 A;  2OIP A;  4M6L A;  3KJS A;  3K47 A;  2CD2 A;  4KD7 A;  4I1N A;  3IRM A;  4PTJ A;  2DHF A;  4DDR A;  1HFR A;  4KY4 A;  4LAE X;  4FHB A;  1RA2 A;  4M2X A;  3F0X X;  5JA3 A;  2BLC A;  1DYJ A;  4KJJ A;  1TDR A;  3EX8 A;  3UM8 A;  3NZA X;  1DIS A;  5HVB A;  4QLE A;  1PD8 A;  2OBC A;  3QLZ A;  1S3V A;  1KMV A;  5HQY A;  1U72 A;  1RG7 A;  4H98 A;  3IA4 A;  1DDR A;  4QLG A;  1M79 A;  1DYI A;  1DDS A;  1DR1 A;  3RG9 A;  4LAG X;  4Q67 A;  3DL5 A;  3E0B A;  4M7V A;  3JWC A;  3SRQ X;  1DRA A;  4PSS A;  3F8Z A;  1RX6 A;  4PSY A;  2D5N A;  1DYH A;  4X5G A;  4XRB A;  4FGH A;  7DFR A;  2W3M A;  1RX9 A;  1HFP A;  4X5H A;  1AOE A;  5U27 A;  1BZF A;  3S3V A;  4XT4 A;  3DFR A;  5HPB A;  3EEJ A;  1U71 A;  5HSR A;  4KL9 A;  1DR7 A;  1RB2 A;  4LEK X;  3QG2 A;  3OCH A;  3HBB A;  2W3W A;  3VCO A;  4IXE D;  4KJL A;  3ZPC A;  4PST A;  4KLX A;  1PDB A;  3QLX A;  1AI9 A;  3TQA A;  2LF1 A;  3K74 A;  5E8Q A;  1D1G A;  3DAU A;  1U70 A;  1DLS A;  4CD2 A;  4HA9 A;  4H96 A;  4IXF X;  1DG8 A;  1DAJ A;  1QZF A;  4P68 A;  1J3I A;  4X5J A;  2BLB A;  2ZZA A;  4OR7 A;  1RA1 A;  1HFQ A;  4KBN A;  3NXO A;  3CD2 A;  3EIG A;  3F0S X;  3FYV X;  4QJZ D;  4HA7 A;  1RX4 A;  4G3M A;  1E26 A;  1DHJ A;  1DRF A;  2ITH A;  4XT7 A;  3TQ8 A;  1JUV A;  2FZH A;  4EIL A;  2W3V A;  4XEC X;  4XT6 A;  1IA4 A;  1RH3 A;  5CC9 A;  3GI2 A;  3QFX A;  4ELG A;  3HJ3 A;  3F8Y A;  3N0H A;  2G6V A;  8DFR A;  1AO8 A;  5HI6 A;  3DAT A;  1ZDR A;  1DR5 A;  3S7A A;  1PD9 A;  5HF2 X;  4G8Z X;  4M6J A; 
#chains in the Genus database with same CATH homology
 1RX7 A;  3FQ0 A;  3I3R A;  4X5I A;  1DRH A;  4ELE A;  4KY8 A;  1DLR A;  5ECC A;  3F91 A;  3NXY A;  4ELB A;  4EJ1 A;  2C2T A;  1IA3 A;  2FZI A;  2HQP A;  4H95 A;  3SRR X;  3S9U A;  3M08 A;  1DRE A;  4DPD A;  6DFR A;  4GH8 A;  4KYA A;  3JWF A;  4H97 A;  3OAF A;  4EIG A;  1S3W A;  3NZD A;  3D80 A;  4IXG X;  4HOF A;  1RX3 A;  4QHV A;  4FGG A;  4PDJ A;  2BL9 A;  4DPH A;  3FRB X;  1S3Y A;  5HT4 A;  3FYW X;  4Q6A A;  4LAH X;  3SRW X;  3SRS X;  3JWM A;  4KNE A;  4PTH A;  4P3R A;  1RX1 A;  4KFJ A;  5CCC A;  3FRE X;  3K2H A;  1RD7 A;  3R33 A;  1KMS A;  4QI9 A;  3EEK A;  3UM5 A;  1SEJ A;  3FS6 A;  5FDA A;  3FRF X;  4P66 A;  1RC4 A;  4KJK A;  3QLR A;  2INQ A;  3K45 A;  2DRC A;  5HF0 X;  1RX2 A;  3NTZ A;  3SA1 A;  3IRO A;  2W9S A;  4DFR A;  3QLS A;  5HVE A;  1RF7 A;  3JWK A;  3FL9 A;  5DFR A;  3NU0 A;  2HXV A;  3SRU X;  1JOM A;  2ANO A;  3CLB A;  3FQC A;  1MVT A;  2W9T A;  1JOL A;  3GHV A;  3ZPG A;  3JVX A;  3NXT A;  3SR5 X;  4KEB A;  3IX9 A;  4I13 A;  2C2S A;  3CL9 A;  4XE6 X;  2W9H A;  2JYB A;  4QLF A;  1VJ3 A;  5EAJ A;  3M09 A;  4X5F A;  3FY9 X;  3FQV A;  1DIU A;  4DP3 A;  3JTW A;  3SGY A;  3FQZ A;  5HT5 A;  3QLW A;  2B3Z A;  4XT5 A;  5HUI A;  3DGA A;  1M7A A;  3NRR A;  3GYF A;  2QK8 A;  1J3J A;  2W3A A;  2AZN A;  2FZJ A;  4Q0D A;  3NZB X;  2GD9 A;  3EEL A;  3RO9 A;  4KM0 A;  3KY8 A;  1DR6 A;  3DG8 A;  4XT8 A;  2KGK A;  3FQF A;  2L28 A;  1CD2 A;  1RE7 A;  3NZC X;  4M7U A;  4OSG A;  4ELH A;  4KAK A;  2BLA A;  1MVS A;  3F0B X;  3LG4 A;  4G95 A;  3KJR A;  1RX5 A;  4HOE A;  1YHO A;  5ECX A;  1M78 A;  1RA8 A;  3GHC A;  4Q0E A;  1DHF A;  4ELF A;  1RX8 A;  4M6K A;  3QL0 A;  1LUD A;  3QLY A;  3DRC A;  3GHW A;  2W3B A;  2W9G A;  3NZ9 X;  3IA5 A;  1DG5 A;  4P3Q A;  2XW7 A;  3QYL A;  2ANQ A;  4NX6 A;  4TU5 X;  4EIZ A;  1RB3 A;  3Q1H A;  3JW3 A;  3FL8 A;  4RGC A;  3SQY X;  1DG7 A;  1DR4 A;  3KFY A;  3IRN A;  1OHK A;  3FRA X;  4KM2 A;  3FY8 X;  3QYO A;  3SAI A;  1J3K A;  1LY4 A;  3SH2 A;  2CIG A;  1DRB A;  3QGT A;  1VDR A;  3FRD X;  4ECK A;  2H2Q A;  3NZ6 X;  1DHI A;  5HQZ A;  3TD8 A;  3KGY A;  3NXR A;  3F0Q X;  5JG0 X;  1LY3 A;  4HOG A;  3FQO A;  5DXV A;  2P4G A;  1IA1 A;  1DYR A;  3L3R A;  3CSE A;  1RA3 A;  3JW5 A;  3ROA A;  3INV A;  3SA2 A;  3EEM A;  1CZ3 A;  3UM6 A;  4QJC A;  1IA2 A;  3F0U X;  1DR2 A;  4NX7 A;  3I8A X;  3TQB A;  5HSU A;  3JSU A;  2D0K A;  3QL3 A;  1DF7 A;  5U26 A;  3TQ9 A;  2O7P A;  3F0V X;  3NXV A;  1RA9 A;  1BOZ A;  3DL6 A;  1OHJ A;  1KLK A;  1S3U A;  2HM9 A;  3D84 X;  3NXX A;  1DR3 A;  2OIP A;  4M6L A;  3KJS A;  3K47 A;  2CD2 A;  4KD7 A;  4I1N A;  3IRM A;  4PTJ A;  2DHF A;  4DDR A;  1HFR A;  4KY4 A;  4LAE X;  4FHB A;  1RA2 A;  4M2X A;  3F0X X;  5JA3 A;  2BLC A;  1DYJ A;  4KJJ A;  1TDR A;  3EX8 A;  3UM8 A;  3NZA X;  1DIS A;  5HVB A;  4QLE A;  1PD8 A;  2OBC A;  3QLZ A;  1S3V A;  1KMV A;  5HQY A;  1U72 A;  1RG7 A;  4H98 A;  3IA4 A;  1DDR A;  4QLG A;  1M79 A;  1DYI A;  1DDS A;  1DR1 A;  3RG9 A;  4LAG X;  4Q67 A;  3DL5 A;  3E0B A;  4M7V A;  3JWC A;  3SRQ X;  1DRA A;  4PSS A;  3F8Z A;  1RX6 A;  4PSY A;  2D5N A;  1DYH A;  4X5G A;  4XRB A;  4FGH A;  7DFR A;  2W3M A;  1RX9 A;  1HFP A;  4X5H A;  1AOE A;  5U27 A;  1BZF A;  3S3V A;  4XT4 A;  3DFR A;  5HPB A;  3EEJ A;  1U71 A;  5HSR A;  4KL9 A;  1DR7 A;  1RB2 A;  4LEK X;  3QG2 A;  3OCH A;  3HBB A;  2W3W A;  3VCO A;  4IXE D;  4KJL A;  3ZPC A;  4PST A;  4KLX A;  1PDB A;  3QLX A;  1AI9 A;  3TQA A;  2LF1 A;  3K74 A;  5E8Q A;  1D1G A;  3DAU A;  1U70 A;  1DLS A;  4CD2 A;  4HA9 A;  4H96 A;  4IXF X;  1DG8 A;  1DAJ A;  1QZF A;  4P68 A;  1J3I A;  4X5J A;  2BLB A;  2ZZA A;  4OR7 A;  1RA1 A;  1HFQ A;  4KBN A;  3NXO A;  3CD2 A;  3EIG A;  3F0S X;  3FYV X;  4QJZ D;  4HA7 A;  1RX4 A;  4G3M A;  1E26 A;  1DHJ A;  1DRF A;  2ITH A;  4XT7 A;  3TQ8 A;  1JUV A;  2FZH A;  4EIL A;  2W3V A;  4XEC X;  4XT6 A;  1IA4 A;  1RH3 A;  5CC9 A;  3GI2 A;  3QFX A;  4ELG A;  3HJ3 A;  3F8Y A;  3N0H A;  2G6V A;  8DFR A;  1AO8 A;  5HI6 A;  3DAT A;  1ZDR A;  1DR5 A;  3S7A A;  1PD9 A;  5HF2 X;  4G8Z X;  4M6J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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