3S3VA

Human dihydrofolate reductase q35k/n64f double mutant binary complex with trimethoprim
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFKRMTTTSSVEGKQNLVIMGKKTWFSIPEKFRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.
pubmed doi rcsb
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 52
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2011-05-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3s3vA00
3JW3A 3F91A 3SRRX 1ZDRA 2P4GA 1AI9A 1DLSA 3DFRA 3F0UX 4PTHA 3HJ3A 1PDBA 4XRBA 1RE7A 3S7AA 5HSUA 1IA3A 3JTWA 3I8AX 1IA1A 3F0VX 4KBNA 4EIGA 3ROAA 5HI6A 3IX9A 3ZPCA 3SRWX 3QLZA 3FL8A 3DGAA 3K45A 1S3WA 3F0BX 4FHBA 4M6LA 1CZ3A 2C2TA 4PSYA 3NXYA 1RA1A 8DFRA 5DXVA 1DRHA 1RA2A 3JW5A 4HA9A 1BOZA 1KMVA 3F8ZA 4H97A 4LAEX 1DR6A 1BZFA 5U27A 4XE6X 1RX3A 1JUVA 2CIGA 4X5JA 4XT8A 2JYBA 2ANOA 2W3MA 2L28A 1DG8A 2LF1A 3NU0A 2W3WA 3NXOA 3FQOA 3F8YA 3S3VA 2W3AA 1DR5A 1DDSA 4QHVA 3IRMA 3LG4A 4PSSA 3SR5X 3QL0A 1DDRA 5DFRA 3EEKA 1RX9A 4I1NA 3GHCA 1RX6A 1LY3A 2W3BA 5FDAA 3JWMA 4IXFX 4X5HA 3KJRA 4P68A 1J3IA 5E8QA 2KGKA 4KM0A 3K47A 3Q1HA 3DL5A 3SRSX 5U26A 3I3RA 1DLRA 2BLBA 4KEBA 3DAUA 1LUDA 3QGTA 3IROA 1DF7A 3FQZA 3SRUX 4HOEA 4PDJA 5HT4A 3E0BA 4QJCA 3INVA 5ECCA 3EEJA 3OAFA 4P66A 3FQ0A 2DRCA 3DL6A 4Q67A 1OHJA 5EAJA 1RD7A 3VCOA 5JG0X 2ITHA 3D84X 4ELFA 1J3KA 3TQ8A 4PTJA 1TDRA 1DRBA 2D0KA 5HQZA 1MVTA 4HOFA 3SQYX 4QLEA 1RF7A 4H95A 2W3VA 3SH2A 2H2QA 3SA2A 3JWFA 1S3VA 3UM8A 3FQFA 3FS6A 1DHFA 3FQVA 2D5NA 1RB2A 3K74A 5HVBA 1RX5A 3F0XX 1DHJA 3F0QX 4H98A 1DR2A 1J3JA 1DR1A 3QLWA 2HXVA 5HSRA 4P3RA 3QYOA 1KMSA 2CD2A 4FGGA 4OSGA 1U72A 5HQYA 1RX4A 4H96A 2G6VA 1AO8A 2BLCA 3NZ9X 2BLAA 1DREA 1DR3A 3NZBX 1DR7A 1M7AA 4Q6AA 3GI2A 4I13A 3QYLA 3FYWX 1E26A 1DYIA 2INQA 3FQCA 1DRFA 4NX6A 1S3YA 3QL3A 4QI9A 2W9SA 3FL9A 3RG9A 1HFRA 3CLBA 4X5IA 3GYFA 4KJJA 1DG7A 2C2SA 1RX8A 2B3ZA 3KJSA 4IXGX 3TQBA 4LAGX 3OCHA 3JWKA 3QLRA 4EIZA 1DYJA 5HUIA 4KL9A 1RX2A 1DYRA 4KLXA 1HFQA 1S3UA 3SAIA 6DFRA 4X5GA 3IA5A 1RA9A 3CSEA 3TQAA 4XT4A 3KY8A 3L3RA 4HA7A 4ELHA 1JOLA 4DPDA 3NXRA 3DG8A 4KD7A 2W9HA 2O7PA 2ZZAA 3N0HA 1DHIA 2FZHA 3FY8X 2QK8A 2W9GA 3EX8A 4IXED 4M6KA 4G3MA 2ANQA 1YHOA 3IRNA 3EEMA 3DRCA 4DP3A 1DR4A 2BL9A 4XT6A 1RX1A 4KFJA 3CD2A 2OBCA 4ELBA 1PD8A 2W9TA 3UM5A 1IA2A 2DHFA 4FGHA 3NZDA 3GHVA 2HQPA 1DAJA 1RA3A 1AOEA 4Q0EA 4EJ1A 3NZCX 1CD2A 3FY9X 3KFYA 5HT5A 1IA4A 4G8ZX 1U70A 4M6JA 3NZ6X 4ECKA 1D1GA 3SRQX 3F0SX 2AZNA 1DISA 5HF0X 1U71A 1LY4A 4PSTA 1M78A 3QFXA 5CC9A 1DRAA 1SEJA 4XT5A 5JA3A 4HOGA 4M2XA 1MVSA 4NX7A 3NXTA 3UM6A 1M79A 1RA8A 1DIUA 4QLFA 3SGYA 3FRFX 4ELEA 5CCCA 1DYHA 4KJLA 2FZJA 3GHWA 2XW7A 1RB3A 3FRBX 1KLKA 1VJ3A 5HVEA 2FZIA 4GH8A 4OR7A 1OHKA 3SA1A 4RGCA 3JWCA 3JSUA 3R33A 3CL9A 3QG2A 4DPHA 4TU5X 7DFRA 3M08A 2HM9A 1VDRA 4QLGA 3EELA 4Q0DA 4X5FA 4KM2A 3S9UA 3FYVX 4M7UA 4KYAA 3K2HA 1DG5A 3TD8A 4KNEA 1RX7A 3QLXA 4CD2A 2OIPA 1RH3A 4QJZD 3FRDX 3M09A 3HBBA 3JVXA 3EIGA 3NXVA 3D80A 3FRAX 4KY8A 4XT7A 3ZPGA 4XECX 5HPBA 1HFPA 4P3QA 4G95A 3KGYA 3DATA 5ECXA 4LAHX 4KAKA 1PD9A 4M7VA 3NZAX 4ELGA 1RG7A 3NTZA 4LEKX 5HF2X 2GD9A 4DDRA 3RO9A 1RC4A 3QLYA 4KJKA 3FREX 3NRRA 1QZFA 3TQ9A 3QLSA 1JOMA 3IA4A 3NXXA 4KY4A 4EILA 4DFRA
chains in the Genus database with same CATH superfamily
3JW3A 3F91A 3SRRX 1ZDRA 2P4GA 1AI9A 1DLSA 3DFRA 3F0UX 4PTHA 3HJ3A 1PDBA 4XRBA 1RE7A 3S7AA 5HSUA 1IA3A 3JTWA 3I8AX 1IA1A 3F0VX 4KBNA 4EIGA 3ROAA 5HI6A 3IX9A 3ZPCA 3SRWX 3QLZA 3FL8A 3DGAA 3K45A 1S3WA 3F0BX 4FHBA 4M6LA 1CZ3A 2C2TA 4PSYA 3NXYA 1RA1A 8DFRA 5DXVA 1DRHA 1RA2A 3JW5A 4HA9A 1BOZA 1KMVA 3F8ZA 4H97A 4LAEX 1DR6A 1BZFA 5U27A 4XE6X 1RX3A 1JUVA 2CIGA 4X5JA 4XT8A 2JYBA 2ANOA 2W3MA 2L28A 1DG8A 2LF1A 3NU0A 2W3WA 3NXOA 3FQOA 3F8YA 3S3VA 2W3AA 1DR5A 1DDSA 4QHVA 3IRMA 3LG4A 4PSSA 3SR5X 3QL0A 1DDRA 5DFRA 3EEKA 1RX9A 4I1NA 3GHCA 1RX6A 1LY3A 2W3BA 5FDAA 3JWMA 4IXFX 4X5HA 3KJRA 4P68A 1J3IA 5E8QA 2KGKA 4KM0A 3K47A 3Q1HA 3DL5A 3SRSX 5U26A 3I3RA 1DLRA 2BLBA 4KEBA 3DAUA 1LUDA 3QGTA 3IROA 1DF7A 3FQZA 3SRUX 4HOEA 4PDJA 5HT4A 3E0BA 4QJCA 3INVA 5ECCA 3EEJA 3OAFA 4P66A 3FQ0A 2DRCA 3DL6A 4Q67A 1OHJA 5EAJA 1RD7A 3VCOA 5JG0X 2ITHA 3D84X 4ELFA 1J3KA 3TQ8A 4PTJA 1TDRA 1DRBA 2D0KA 5HQZA 1MVTA 4HOFA 3SQYX 4QLEA 1RF7A 4H95A 2W3VA 3SH2A 2H2QA 3SA2A 3JWFA 1S3VA 3UM8A 3FQFA 3FS6A 1DHFA 3FQVA 2D5NA 1RB2A 3K74A 5HVBA 1RX5A 3F0XX 1DHJA 3F0QX 4H98A 1DR2A 1J3JA 1DR1A 3QLWA 2HXVA 5HSRA 4P3RA 3QYOA 1KMSA 2CD2A 4FGGA 4OSGA 1U72A 5HQYA 1RX4A 4H96A 2G6VA 1AO8A 2BLCA 3NZ9X 2BLAA 1DREA 1DR3A 3NZBX 1DR7A 1M7AA 4Q6AA 3GI2A 4I13A 3QYLA 3FYWX 1E26A 1DYIA 2INQA 3FQCA 1DRFA 4NX6A 1S3YA 3QL3A 4QI9A 2W9SA 3FL9A 3RG9A 1HFRA 3CLBA 4X5IA 3GYFA 4KJJA 1DG7A 2C2SA 1RX8A 2B3ZA 3KJSA 4IXGX 3TQBA 4LAGX 3OCHA 3JWKA 3QLRA 4EIZA 1DYJA 5HUIA 4KL9A 1RX2A 1DYRA 4KLXA 1HFQA 1S3UA 3SAIA 6DFRA 4X5GA 3IA5A 1RA9A 3CSEA 3TQAA 4XT4A 3KY8A 3L3RA 4HA7A 4ELHA 1JOLA 4DPDA 3NXRA 3DG8A 4KD7A 2W9HA 2O7PA 2ZZAA 3N0HA 1DHIA 2FZHA 3FY8X 2QK8A 2W9GA 3EX8A 4IXED 4M6KA 4G3MA 2ANQA 1YHOA 3IRNA 3EEMA 3DRCA 4DP3A 1DR4A 2BL9A 4XT6A 1RX1A 4KFJA 3CD2A 2OBCA 4ELBA 1PD8A 2W9TA 3UM5A 1IA2A 2DHFA 4FGHA 3NZDA 3GHVA 2HQPA 1DAJA 1RA3A 1AOEA 4Q0EA 4EJ1A 3NZCX 1CD2A 3FY9X 3KFYA 5HT5A 1IA4A 4G8ZX 1U70A 4M6JA 3NZ6X 4ECKA 1D1GA 3SRQX 3F0SX 2AZNA 1DISA 5HF0X 1U71A 1LY4A 4PSTA 1M78A 3QFXA 5CC9A 1DRAA 1SEJA 4XT5A 5JA3A 4HOGA 4M2XA 1MVSA 4NX7A 3NXTA 3UM6A 1M79A 1RA8A 1DIUA 4QLFA 3SGYA 3FRFX 4ELEA 5CCCA 1DYHA 4KJLA 2FZJA 3GHWA 2XW7A 1RB3A 3FRBX 1KLKA 1VJ3A 5HVEA 2FZIA 4GH8A 4OR7A 1OHKA 3SA1A 4RGCA 3JWCA 3JSUA 3R33A 3CL9A 3QG2A 4DPHA 4TU5X 7DFRA 3M08A 2HM9A 1VDRA 4QLGA 3EELA 4Q0DA 4X5FA 4KM2A 3S9UA 3FYVX 4M7UA 4KYAA 3K2HA 1DG5A 3TD8A 4KNEA 1RX7A 3QLXA 4CD2A 2OIPA 1RH3A 4QJZD 3FRDX 3M09A 3HBBA 3JVXA 3EIGA 3NXVA 3D80A 3FRAX 4KY8A 4XT7A 3ZPGA 4XECX 5HPBA 1HFPA 4P3QA 4G95A 3KGYA 3DATA 5ECXA 4LAHX 4KAKA 1PD9A 4M7VA 3NZAX 4ELGA 1RG7A 3NTZA 4LEKX 5HF2X 2GD9A 4DDRA 3RO9A 1RC4A 3QLYA 4KJKA 3FREX 3NRRA 1QZFA 3TQ9A 3QLSA 1JOMA 3IA4A 3NXXA 4KY4A 4EILA 4DFRA
chains in the Genus database with same CATH topology
3JW3A 3F91A 3SRRX 1ZDRA 2P4GA 1AI9A 1DLSA 3DFRA 3F0UX 4PTHA 3HJ3A 1PDBA 4XRBA 1RE7A 3S7AA 5HSUA 1IA3A 3JTWA 3I8AX 1IA1A 3F0VX 4KBNA 4EIGA 3ROAA 5HI6A 3IX9A 3ZPCA 3SRWX 3QLZA 3FL8A 3DGAA 3K45A 1S3WA 3F0BX 4FHBA 4M6LA 1CZ3A 2C2TA 4PSYA 3NXYA 1RA1A 8DFRA 5DXVA 1DRHA 1RA2A 3JW5A 4HA9A 1BOZA 1KMVA 3F8ZA 4H97A 4LAEX 1DR6A 1BZFA 5U27A 4XE6X 1RX3A 1JUVA 2CIGA 4X5JA 4XT8A 2JYBA 2ANOA 2W3MA 2L28A 1DG8A 2LF1A 3NU0A 2W3WA 3NXOA 3FQOA 3F8YA 3S3VA 2W3AA 1DR5A 1DDSA 4QHVA 3IRMA 3LG4A 4PSSA 3SR5X 3QL0A 1DDRA 5DFRA 3EEKA 1RX9A 4I1NA 3GHCA 1RX6A 1LY3A 2W3BA 5FDAA 3JWMA 4IXFX 4X5HA 3KJRA 4P68A 1J3IA 5E8QA 2KGKA 4KM0A 3K47A 3Q1HA 3DL5A 3SRSX 5U26A 3I3RA 1DLRA 2BLBA 4KEBA 3DAUA 1LUDA 3QGTA 3IROA 1DF7A 3FQZA 3SRUX 4HOEA 4PDJA 5HT4A 3E0BA 4QJCA 3INVA 5ECCA 3EEJA 3OAFA 4P66A 3FQ0A 2DRCA 3DL6A 4Q67A 1OHJA 5EAJA 1RD7A 3VCOA 5JG0X 2ITHA 3D84X 4ELFA 1J3KA 3TQ8A 4PTJA 1TDRA 1DRBA 2D0KA 5HQZA 1MVTA 4HOFA 3SQYX 4QLEA 1RF7A 4H95A 2W3VA 3SH2A 2H2QA 3SA2A 3JWFA 1S3VA 3UM8A 3FQFA 3FS6A 1DHFA 3FQVA 2D5NA 1RB2A 3K74A 5HVBA 1RX5A 3F0XX 1DHJA 3F0QX 4H98A 1DR2A 1J3JA 1DR1A 3QLWA 2HXVA 5HSRA 4P3RA 3QYOA 1KMSA 2CD2A 4FGGA 4OSGA 1U72A 5HQYA 1RX4A 4H96A 2G6VA 1AO8A 2BLCA 3NZ9X 2BLAA 1DREA 1DR3A 3NZBX 1DR7A 1M7AA 4Q6AA 3GI2A 4I13A 3QYLA 3FYWX 1E26A 1DYIA 2INQA 3FQCA 1DRFA 4NX6A 1S3YA 3QL3A 4QI9A 2W9SA 3FL9A 3RG9A 1HFRA 3CLBA 4X5IA 3GYFA 4KJJA 1DG7A 2C2SA 1RX8A 2B3ZA 3KJSA 4IXGX 3TQBA 4LAGX 3OCHA 3JWKA 3QLRA 4EIZA 1DYJA 5HUIA 4KL9A 1RX2A 1DYRA 4KLXA 1HFQA 1S3UA 3SAIA 6DFRA 4X5GA 3IA5A 1RA9A 3CSEA 3TQAA 4XT4A 3KY8A 3L3RA 4HA7A 4ELHA 1JOLA 4DPDA 3NXRA 3DG8A 4KD7A 2W9HA 2O7PA 2ZZAA 3N0HA 1DHIA 2FZHA 3FY8X 2QK8A 2W9GA 3EX8A 4IXED 4M6KA 4G3MA 2ANQA 1YHOA 3IRNA 3EEMA 3DRCA 4DP3A 1DR4A 2BL9A 4XT6A 1RX1A 4KFJA 3CD2A 2OBCA 4ELBA 1PD8A 2W9TA 3UM5A 1IA2A 2DHFA 4FGHA 3NZDA 3GHVA 2HQPA 1DAJA 1RA3A 1AOEA 4Q0EA 4EJ1A 3NZCX 1CD2A 3FY9X 3KFYA 5HT5A 1IA4A 4G8ZX 1U70A 4M6JA 3NZ6X 4ECKA 1D1GA 3SRQX 3F0SX 2AZNA 1DISA 5HF0X 1U71A 1LY4A 4PSTA 1M78A 3QFXA 5CC9A 1DRAA 1SEJA 4XT5A 5JA3A 4HOGA 4M2XA 1MVSA 4NX7A 3NXTA 3UM6A 1M79A 1RA8A 1DIUA 4QLFA 3SGYA 3FRFX 4ELEA 5CCCA 1DYHA 4KJLA 2FZJA 3GHWA 2XW7A 1RB3A 3FRBX 1KLKA 1VJ3A 5HVEA 2FZIA 4GH8A 4OR7A 1OHKA 3SA1A 4RGCA 3JWCA 3JSUA 3R33A 3CL9A 3QG2A 4DPHA 4TU5X 7DFRA 3M08A 2HM9A 1VDRA 4QLGA 3EELA 4Q0DA 4X5FA 4KM2A 3S9UA 3FYVX 4M7UA 4KYAA 3K2HA 1DG5A 3TD8A 4KNEA 1RX7A 3QLXA 4CD2A 2OIPA 1RH3A 4QJZD 3FRDX 3M09A 3HBBA 3JVXA 3EIGA 3NXVA 3D80A 3FRAX 4KY8A 4XT7A 3ZPGA 4XECX 5HPBA 1HFPA 4P3QA 4G95A 3KGYA 3DATA 5ECXA 4LAHX 4KAKA 1PD9A 4M7VA 3NZAX 4ELGA 1RG7A 3NTZA 4LEKX 5HF2X 2GD9A 4DDRA 3RO9A 1RC4A 3QLYA 4KJKA 3FREX 3NRRA 1QZFA 3TQ9A 3QLSA 1JOMA 3IA4A 3NXXA 4KY4A 4EILA 4DFRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3JW3 A;  3F91 A;  3SRR X;  1ZDR A;  2P4G A;  1AI9 A;  1DLS A;  3DFR A;  3F0U X;  4PTH A;  3HJ3 A;  1PDB A;  4XRB A;  1RE7 A;  3S7A A;  5HSU A;  1IA3 A;  3JTW A;  3I8A X;  1IA1 A;  3F0V X;  4KBN A;  4EIG A;  3ROA A;  5HI6 A;  3IX9 A;  3ZPC A;  3SRW X;  3QLZ A;  3FL8 A;  3DGA A;  3K45 A;  1S3W A;  3F0B X;  4FHB A;  4M6L A;  1CZ3 A;  2C2T A;  4PSY A;  3NXY A;  1RA1 A;  8DFR A;  5DXV A;  1DRH A;  1RA2 A;  3JW5 A;  4HA9 A;  1BOZ A;  1KMV A;  3F8Z A;  4H97 A;  4LAE X;  1DR6 A;  1BZF A;  5U27 A;  4XE6 X;  1RX3 A;  1JUV A;  2CIG A;  4X5J A;  4XT8 A;  2JYB A;  2ANO A;  2W3M A;  2L28 A;  1DG8 A;  2LF1 A;  3NU0 A;  2W3W A;  3NXO A;  3FQO A;  3F8Y A;  3S3V A;  2W3A A;  1DR5 A;  1DDS A;  4QHV A;  3IRM A;  3LG4 A;  4PSS A;  3SR5 X;  3QL0 A;  1DDR A;  5DFR A;  3EEK A;  1RX9 A;  4I1N A;  3GHC A;  1RX6 A;  1LY3 A;  2W3B A;  5FDA A;  3JWM A;  4IXF X;  4X5H A;  3KJR A;  4P68 A;  1J3I A;  5E8Q A;  2KGK A;  4KM0 A;  3K47 A;  3Q1H A;  3DL5 A;  3SRS X;  5U26 A;  3I3R A;  1DLR A;  2BLB A;  4KEB A;  3DAU A;  1LUD A;  3QGT A;  3IRO A;  1DF7 A;  3FQZ A;  3SRU X;  4HOE A;  4PDJ A;  5HT4 A;  3E0B A;  4QJC A;  3INV A;  5ECC A;  3EEJ A;  3OAF A;  4P66 A;  3FQ0 A;  2DRC A;  3DL6 A;  4Q67 A;  1OHJ A;  5EAJ A;  1RD7 A;  3VCO A;  5JG0 X;  2ITH A;  3D84 X;  4ELF A;  1J3K A;  3TQ8 A;  4PTJ A;  1TDR A;  1DRB A;  2D0K A;  5HQZ A;  1MVT A;  4HOF A;  3SQY X;  4QLE A;  1RF7 A;  4H95 A;  2W3V A;  3SH2 A;  2H2Q A;  3SA2 A;  3JWF A;  1S3V A;  3UM8 A;  3FQF A;  3FS6 A;  1DHF A;  3FQV A;  2D5N A;  1RB2 A;  3K74 A;  5HVB A;  1RX5 A;  3F0X X;  1DHJ A;  3F0Q X;  4H98 A;  1DR2 A;  1J3J A;  1DR1 A;  3QLW A;  2HXV A;  5HSR A;  4P3R A;  3QYO A;  1KMS A;  2CD2 A;  4FGG A;  4OSG A;  1U72 A;  5HQY A;  1RX4 A;  4H96 A;  2G6V A;  1AO8 A;  2BLC A;  3NZ9 X;  2BLA A;  1DRE A;  1DR3 A;  3NZB X;  1DR7 A;  1M7A A;  4Q6A A;  3GI2 A;  4I13 A;  3QYL A;  3FYW X;  1E26 A;  1DYI A;  2INQ A;  3FQC A;  1DRF A;  4NX6 A;  1S3Y A;  3QL3 A;  4QI9 A;  2W9S A;  3FL9 A;  3RG9 A;  1HFR A;  3CLB A;  4X5I A;  3GYF A;  4KJJ A;  1DG7 A;  2C2S A;  1RX8 A;  2B3Z A;  3KJS A;  4IXG X;  3TQB A;  4LAG X;  3OCH A;  3JWK A;  3QLR A;  4EIZ A;  1DYJ A;  5HUI A;  4KL9 A;  1RX2 A;  1DYR A;  4KLX A;  1HFQ A;  1S3U A;  3SAI A;  6DFR A;  4X5G A;  3IA5 A;  1RA9 A;  3CSE A;  3TQA A;  4XT4 A;  3KY8 A;  3L3R A;  4HA7 A;  4ELH A;  1JOL A;  4DPD A;  3NXR A;  3DG8 A;  4KD7 A;  2W9H A;  2O7P A;  2ZZA A;  3N0H A;  1DHI A;  2FZH A;  3FY8 X;  2QK8 A;  2W9G A;  3EX8 A;  4IXE D;  4M6K A;  4G3M A;  2ANQ A;  1YHO A;  3IRN A;  3EEM A;  3DRC A;  4DP3 A;  1DR4 A;  2BL9 A;  4XT6 A;  1RX1 A;  4KFJ A;  3CD2 A;  2OBC A;  4ELB A;  1PD8 A;  2W9T A;  3UM5 A;  1IA2 A;  2DHF A;  4FGH A;  3NZD A;  3GHV A;  2HQP A;  1DAJ A;  1RA3 A;  1AOE A;  4Q0E A;  4EJ1 A;  3NZC X;  1CD2 A;  3FY9 X;  3KFY A;  5HT5 A;  1IA4 A;  4G8Z X;  1U70 A;  4M6J A;  3NZ6 X;  4ECK A;  1D1G A;  3SRQ X;  3F0S X;  2AZN A;  1DIS A;  5HF0 X;  1U71 A;  1LY4 A;  4PST A;  1M78 A;  3QFX A;  5CC9 A;  1DRA A;  1SEJ A;  4XT5 A;  5JA3 A;  4HOG A;  4M2X A;  1MVS A;  4NX7 A;  3NXT A;  3UM6 A;  1M79 A;  1RA8 A;  1DIU A;  4QLF A;  3SGY A;  3FRF X;  4ELE A;  5CCC A;  1DYH A;  4KJL A;  2FZJ A;  3GHW A;  2XW7 A;  1RB3 A;  3FRB X;  1KLK A;  1VJ3 A;  5HVE A;  2FZI A;  4GH8 A;  4OR7 A;  1OHK A;  3SA1 A;  4RGC A;  3JWC A;  3JSU A;  3R33 A;  3CL9 A;  3QG2 A;  4DPH A;  4TU5 X;  7DFR A;  3M08 A;  2HM9 A;  1VDR A;  4QLG A;  3EEL A;  4Q0D A;  4X5F A;  4KM2 A;  3S9U A;  3FYV X;  4M7U A;  4KYA A;  3K2H A;  1DG5 A;  3TD8 A;  4KNE A;  1RX7 A;  3QLX A;  4CD2 A;  2OIP A;  1RH3 A;  4QJZ D;  3FRD X;  3M09 A;  3HBB A;  3JVX A;  3EIG A;  3NXV A;  3D80 A;  3FRA X;  4KY8 A;  4XT7 A;  3ZPG A;  4XEC X;  5HPB A;  1HFP A;  4P3Q A;  4G95 A;  3KGY A;  3DAT A;  5ECX A;  4LAH X;  4KAK A;  1PD9 A;  4M7V A;  3NZA X;  4ELG A;  1RG7 A;  3NTZ A;  4LEK X;  5HF2 X;  2GD9 A;  4DDR A;  3RO9 A;  1RC4 A;  3QLY A;  4KJK A;  3FRE X;  3NRR A;  1QZF A;  3TQ9 A;  3QLS A;  1JOM A;  3IA4 A;  3NXX A;  4KY4 A;  4EIL A;  4DFR A; 
#chains in the Genus database with same CATH topology
 3JW3 A;  3F91 A;  3SRR X;  1ZDR A;  2P4G A;  1AI9 A;  1DLS A;  3DFR A;  3F0U X;  4PTH A;  3HJ3 A;  1PDB A;  4XRB A;  1RE7 A;  3S7A A;  5HSU A;  1IA3 A;  3JTW A;  3I8A X;  1IA1 A;  3F0V X;  4KBN A;  4EIG A;  3ROA A;  5HI6 A;  3IX9 A;  3ZPC A;  3SRW X;  3QLZ A;  3FL8 A;  3DGA A;  3K45 A;  1S3W A;  3F0B X;  4FHB A;  4M6L A;  1CZ3 A;  2C2T A;  4PSY A;  3NXY A;  1RA1 A;  8DFR A;  5DXV A;  1DRH A;  1RA2 A;  3JW5 A;  4HA9 A;  1BOZ A;  1KMV A;  3F8Z A;  4H97 A;  4LAE X;  1DR6 A;  1BZF A;  5U27 A;  4XE6 X;  1RX3 A;  1JUV A;  2CIG A;  4X5J A;  4XT8 A;  2JYB A;  2ANO A;  2W3M A;  2L28 A;  1DG8 A;  2LF1 A;  3NU0 A;  2W3W A;  3NXO A;  3FQO A;  3F8Y A;  3S3V A;  2W3A A;  1DR5 A;  1DDS A;  4QHV A;  3IRM A;  3LG4 A;  4PSS A;  3SR5 X;  3QL0 A;  1DDR A;  5DFR A;  3EEK A;  1RX9 A;  4I1N A;  3GHC A;  1RX6 A;  1LY3 A;  2W3B A;  5FDA A;  3JWM A;  4IXF X;  4X5H A;  3KJR A;  4P68 A;  1J3I A;  5E8Q A;  2KGK A;  4KM0 A;  3K47 A;  3Q1H A;  3DL5 A;  3SRS X;  5U26 A;  3I3R A;  1DLR A;  2BLB A;  4KEB A;  3DAU A;  1LUD A;  3QGT A;  3IRO A;  1DF7 A;  3FQZ A;  3SRU X;  4HOE A;  4PDJ A;  5HT4 A;  3E0B A;  4QJC A;  3INV A;  5ECC A;  3EEJ A;  3OAF A;  4P66 A;  3FQ0 A;  2DRC A;  3DL6 A;  4Q67 A;  1OHJ A;  5EAJ A;  1RD7 A;  3VCO A;  5JG0 X;  2ITH A;  3D84 X;  4ELF A;  1J3K A;  3TQ8 A;  4PTJ A;  1TDR A;  1DRB A;  2D0K A;  5HQZ A;  1MVT A;  4HOF A;  3SQY X;  4QLE A;  1RF7 A;  4H95 A;  2W3V A;  3SH2 A;  2H2Q A;  3SA2 A;  3JWF A;  1S3V A;  3UM8 A;  3FQF A;  3FS6 A;  1DHF A;  3FQV A;  2D5N A;  1RB2 A;  3K74 A;  5HVB A;  1RX5 A;  3F0X X;  1DHJ A;  3F0Q X;  4H98 A;  1DR2 A;  1J3J A;  1DR1 A;  3QLW A;  2HXV A;  5HSR A;  4P3R A;  3QYO A;  1KMS A;  2CD2 A;  4FGG A;  4OSG A;  1U72 A;  5HQY A;  1RX4 A;  4H96 A;  2G6V A;  1AO8 A;  2BLC A;  3NZ9 X;  2BLA A;  1DRE A;  1DR3 A;  3NZB X;  1DR7 A;  1M7A A;  4Q6A A;  3GI2 A;  4I13 A;  3QYL A;  3FYW X;  1E26 A;  1DYI A;  2INQ A;  3FQC A;  1DRF A;  4NX6 A;  1S3Y A;  3QL3 A;  4QI9 A;  2W9S A;  3FL9 A;  3RG9 A;  1HFR A;  3CLB A;  4X5I A;  3GYF A;  4KJJ A;  1DG7 A;  2C2S A;  1RX8 A;  2B3Z A;  3KJS A;  4IXG X;  3TQB A;  4LAG X;  3OCH A;  3JWK A;  3QLR A;  4EIZ A;  1DYJ A;  5HUI A;  4KL9 A;  1RX2 A;  1DYR A;  4KLX A;  1HFQ A;  1S3U A;  3SAI A;  6DFR A;  4X5G A;  3IA5 A;  1RA9 A;  3CSE A;  3TQA A;  4XT4 A;  3KY8 A;  3L3R A;  4HA7 A;  4ELH A;  1JOL A;  4DPD A;  3NXR A;  3DG8 A;  4KD7 A;  2W9H A;  2O7P A;  2ZZA A;  3N0H A;  1DHI A;  2FZH A;  3FY8 X;  2QK8 A;  2W9G A;  3EX8 A;  4IXE D;  4M6K A;  4G3M A;  2ANQ A;  1YHO A;  3IRN A;  3EEM A;  3DRC A;  4DP3 A;  1DR4 A;  2BL9 A;  4XT6 A;  1RX1 A;  4KFJ A;  3CD2 A;  2OBC A;  4ELB A;  1PD8 A;  2W9T A;  3UM5 A;  1IA2 A;  2DHF A;  4FGH A;  3NZD A;  3GHV A;  2HQP A;  1DAJ A;  1RA3 A;  1AOE A;  4Q0E A;  4EJ1 A;  3NZC X;  1CD2 A;  3FY9 X;  3KFY A;  5HT5 A;  1IA4 A;  4G8Z X;  1U70 A;  4M6J A;  3NZ6 X;  4ECK A;  1D1G A;  3SRQ X;  3F0S X;  2AZN A;  1DIS A;  5HF0 X;  1U71 A;  1LY4 A;  4PST A;  1M78 A;  3QFX A;  5CC9 A;  1DRA A;  1SEJ A;  4XT5 A;  5JA3 A;  4HOG A;  4M2X A;  1MVS A;  4NX7 A;  3NXT A;  3UM6 A;  1M79 A;  1RA8 A;  1DIU A;  4QLF A;  3SGY A;  3FRF X;  4ELE A;  5CCC A;  1DYH A;  4KJL A;  2FZJ A;  3GHW A;  2XW7 A;  1RB3 A;  3FRB X;  1KLK A;  1VJ3 A;  5HVE A;  2FZI A;  4GH8 A;  4OR7 A;  1OHK A;  3SA1 A;  4RGC A;  3JWC A;  3JSU A;  3R33 A;  3CL9 A;  3QG2 A;  4DPH A;  4TU5 X;  7DFR A;  3M08 A;  2HM9 A;  1VDR A;  4QLG A;  3EEL A;  4Q0D A;  4X5F A;  4KM2 A;  3S9U A;  3FYV X;  4M7U A;  4KYA A;  3K2H A;  1DG5 A;  3TD8 A;  4KNE A;  1RX7 A;  3QLX A;  4CD2 A;  2OIP A;  1RH3 A;  4QJZ D;  3FRD X;  3M09 A;  3HBB A;  3JVX A;  3EIG A;  3NXV A;  3D80 A;  3FRA X;  4KY8 A;  4XT7 A;  3ZPG A;  4XEC X;  5HPB A;  1HFP A;  4P3Q A;  4G95 A;  3KGY A;  3DAT A;  5ECX A;  4LAH X;  4KAK A;  1PD9 A;  4M7V A;  3NZA X;  4ELG A;  1RG7 A;  3NTZ A;  4LEK X;  5HF2 X;  2GD9 A;  4DDR A;  3RO9 A;  1RC4 A;  3QLY A;  4KJK A;  3FRE X;  3NRR A;  1QZF A;  3TQ9 A;  3QLS A;  1JOM A;  3IA4 A;  3NXX A;  4KY4 A;  4EIL A;  4DFR A; 
#chains in the Genus database with same CATH homology
 3JW3 A;  3F91 A;  3SRR X;  1ZDR A;  2P4G A;  1AI9 A;  1DLS A;  3DFR A;  3F0U X;  4PTH A;  3HJ3 A;  1PDB A;  4XRB A;  1RE7 A;  3S7A A;  5HSU A;  1IA3 A;  3JTW A;  3I8A X;  1IA1 A;  3F0V X;  4KBN A;  4EIG A;  3ROA A;  5HI6 A;  3IX9 A;  3ZPC A;  3SRW X;  3QLZ A;  3FL8 A;  3DGA A;  3K45 A;  1S3W A;  3F0B X;  4FHB A;  4M6L A;  1CZ3 A;  2C2T A;  4PSY A;  3NXY A;  1RA1 A;  8DFR A;  5DXV A;  1DRH A;  1RA2 A;  3JW5 A;  4HA9 A;  1BOZ A;  1KMV A;  3F8Z A;  4H97 A;  4LAE X;  1DR6 A;  1BZF A;  5U27 A;  4XE6 X;  1RX3 A;  1JUV A;  2CIG A;  4X5J A;  4XT8 A;  2JYB A;  2ANO A;  2W3M A;  2L28 A;  1DG8 A;  2LF1 A;  3NU0 A;  2W3W A;  3NXO A;  3FQO A;  3F8Y A;  3S3V A;  2W3A A;  1DR5 A;  1DDS A;  4QHV A;  3IRM A;  3LG4 A;  4PSS A;  3SR5 X;  3QL0 A;  1DDR A;  5DFR A;  3EEK A;  1RX9 A;  4I1N A;  3GHC A;  1RX6 A;  1LY3 A;  2W3B A;  5FDA A;  3JWM A;  4IXF X;  4X5H A;  3KJR A;  4P68 A;  1J3I A;  5E8Q A;  2KGK A;  4KM0 A;  3K47 A;  3Q1H A;  3DL5 A;  3SRS X;  5U26 A;  3I3R A;  1DLR A;  2BLB A;  4KEB A;  3DAU A;  1LUD A;  3QGT A;  3IRO A;  1DF7 A;  3FQZ A;  3SRU X;  4HOE A;  4PDJ A;  5HT4 A;  3E0B A;  4QJC A;  3INV A;  5ECC A;  3EEJ A;  3OAF A;  4P66 A;  3FQ0 A;  2DRC A;  3DL6 A;  4Q67 A;  1OHJ A;  5EAJ A;  1RD7 A;  3VCO A;  5JG0 X;  2ITH A;  3D84 X;  4ELF A;  1J3K A;  3TQ8 A;  4PTJ A;  1TDR A;  1DRB A;  2D0K A;  5HQZ A;  1MVT A;  4HOF A;  3SQY X;  4QLE A;  1RF7 A;  4H95 A;  2W3V A;  3SH2 A;  2H2Q A;  3SA2 A;  3JWF A;  1S3V A;  3UM8 A;  3FQF A;  3FS6 A;  1DHF A;  3FQV A;  2D5N A;  1RB2 A;  3K74 A;  5HVB A;  1RX5 A;  3F0X X;  1DHJ A;  3F0Q X;  4H98 A;  1DR2 A;  1J3J A;  1DR1 A;  3QLW A;  2HXV A;  5HSR A;  4P3R A;  3QYO A;  1KMS A;  2CD2 A;  4FGG A;  4OSG A;  1U72 A;  5HQY A;  1RX4 A;  4H96 A;  2G6V A;  1AO8 A;  2BLC A;  3NZ9 X;  2BLA A;  1DRE A;  1DR3 A;  3NZB X;  1DR7 A;  1M7A A;  4Q6A A;  3GI2 A;  4I13 A;  3QYL A;  3FYW X;  1E26 A;  1DYI A;  2INQ A;  3FQC A;  1DRF A;  4NX6 A;  1S3Y A;  3QL3 A;  4QI9 A;  2W9S A;  3FL9 A;  3RG9 A;  1HFR A;  3CLB A;  4X5I A;  3GYF A;  4KJJ A;  1DG7 A;  2C2S A;  1RX8 A;  2B3Z A;  3KJS A;  4IXG X;  3TQB A;  4LAG X;  3OCH A;  3JWK A;  3QLR A;  4EIZ A;  1DYJ A;  5HUI A;  4KL9 A;  1RX2 A;  1DYR A;  4KLX A;  1HFQ A;  1S3U A;  3SAI A;  6DFR A;  4X5G A;  3IA5 A;  1RA9 A;  3CSE A;  3TQA A;  4XT4 A;  3KY8 A;  3L3R A;  4HA7 A;  4ELH A;  1JOL A;  4DPD A;  3NXR A;  3DG8 A;  4KD7 A;  2W9H A;  2O7P A;  2ZZA A;  3N0H A;  1DHI A;  2FZH A;  3FY8 X;  2QK8 A;  2W9G A;  3EX8 A;  4IXE D;  4M6K A;  4G3M A;  2ANQ A;  1YHO A;  3IRN A;  3EEM A;  3DRC A;  4DP3 A;  1DR4 A;  2BL9 A;  4XT6 A;  1RX1 A;  4KFJ A;  3CD2 A;  2OBC A;  4ELB A;  1PD8 A;  2W9T A;  3UM5 A;  1IA2 A;  2DHF A;  4FGH A;  3NZD A;  3GHV A;  2HQP A;  1DAJ A;  1RA3 A;  1AOE A;  4Q0E A;  4EJ1 A;  3NZC X;  1CD2 A;  3FY9 X;  3KFY A;  5HT5 A;  1IA4 A;  4G8Z X;  1U70 A;  4M6J A;  3NZ6 X;  4ECK A;  1D1G A;  3SRQ X;  3F0S X;  2AZN A;  1DIS A;  5HF0 X;  1U71 A;  1LY4 A;  4PST A;  1M78 A;  3QFX A;  5CC9 A;  1DRA A;  1SEJ A;  4XT5 A;  5JA3 A;  4HOG A;  4M2X A;  1MVS A;  4NX7 A;  3NXT A;  3UM6 A;  1M79 A;  1RA8 A;  1DIU A;  4QLF A;  3SGY A;  3FRF X;  4ELE A;  5CCC A;  1DYH A;  4KJL A;  2FZJ A;  3GHW A;  2XW7 A;  1RB3 A;  3FRB X;  1KLK A;  1VJ3 A;  5HVE A;  2FZI A;  4GH8 A;  4OR7 A;  1OHK A;  3SA1 A;  4RGC A;  3JWC A;  3JSU A;  3R33 A;  3CL9 A;  3QG2 A;  4DPH A;  4TU5 X;  7DFR A;  3M08 A;  2HM9 A;  1VDR A;  4QLG A;  3EEL A;  4Q0D A;  4X5F A;  4KM2 A;  3S9U A;  3FYV X;  4M7U A;  4KYA A;  3K2H A;  1DG5 A;  3TD8 A;  4KNE A;  1RX7 A;  3QLX A;  4CD2 A;  2OIP A;  1RH3 A;  4QJZ D;  3FRD X;  3M09 A;  3HBB A;  3JVX A;  3EIG A;  3NXV A;  3D80 A;  3FRA X;  4KY8 A;  4XT7 A;  3ZPG A;  4XEC X;  5HPB A;  1HFP A;  4P3Q A;  4G95 A;  3KGY A;  3DAT A;  5ECX A;  4LAH X;  4KAK A;  1PD9 A;  4M7V A;  3NZA X;  4ELG A;  1RG7 A;  3NTZ A;  4LEK X;  5HF2 X;  2GD9 A;  4DDR A;  3RO9 A;  1RC4 A;  3QLY A;  4KJK A;  3FRE X;  3NRR A;  1QZF A;  3TQ9 A;  3QLS A;  1JOM A;  3IA4 A;  3NXX A;  4KY4 A;  4EIL A;  4DFR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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