3DGAA

Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf01302, nadph, and dump
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
230
structure length
219
Chain Sequence
MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKEKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.
pubmed doi rcsb
molecule tags Oxidoreductase, transferase
source organism Plasmodium falciparum
molecule keywords Bifunctional dihydrofolate reductase-thymidylate synthase
total genus 63
structure length 219
sequence length 230
chains with identical sequence B
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2008-06-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3dgaA00
2P4GA 4ELEA 1JOMA 3CD2A 4LAHX 1HFPA 5EAJA 3CL9A 4HOFA 2D5NA 2FZJA 4KM2A 4ELFA 3IRMA 5HSRA 1DR3A 4KEBA 4HOGA 4KD7A 5HT4A 2C2TA 3HBBA 3FREX 3I3RA 3DATA 3SRRX 3QLZA 5HI6A 4DP3A 4PSTA 1RA8A 3FL9A 3NXYA 2ANQA 4Q0DA 1RX3A 3NTZA 4QLFA 3KJRA 4P3QA 4ECKA 3FRDX 1SEJA 3NXVA 3R33A 1OHJA 3HJ3A 3ZPGA 3QG2A 5HUIA 3NXXA 1DR2A 5HVBA 4IXGX 2OIPA 3JTWA 4PSSA 1IA4A 3NXRA 1DDRA 4PTHA 4QI9A 1DRHA 5DXVA 1LY3A 3JWCA 1BOZA 3FRAX 4NX6A 3NZAX 4P66A 1CZ3A 3K74A 4H98A 4H96A 3NRRA 2DHFA 1S3YA 3KJSA 3JWKA 4FGGA 3CSEA 4M6KA 3K45A 2XW7A 1DRBA 2FZHA 3QLSA 3FQCA 5HPBA 3FYWX 5HSUA 3FQOA 2C2SA 4IXFX 5ECCA 1J3JA 3TQAA 1DYIA 2ITHA 3DG8A 5DFRA 1KMVA 1RX5A 1RX7A 4X5GA 1RX9A 4KY4A 1RA9A 2CIGA 2AZNA 3ZPCA 1CD2A 1JUVA 3UM5A 1DDSA 1HFRA 2ANOA 3JW3A 2H2QA 4KM0A 3FQFA 1U70A 3EIGA 4KFJA 4H97A 1U71A 3QLYA 4ELHA 4KY8A 2DRCA 3CLBA 4X5JA 1DRFA 3S3VA 5JG0X 3K47A 3DFRA 4Q6AA 1DG7A 3F8ZA 4Q67A 3SAIA 4M7UA 3QLRA 3SRWX 1LY4A 4DPHA 4EILA 3SA1A 3SH2A 1RC4A 3M09A 2HXVA 1DR5A 3EEKA 3RG9A 4LAEX 3D80A 3QLXA 4P68A 1KLKA 4LEKX 4EIGA 1BZFA 3F0VX 1RA3A 3GHWA 3EX8A 5U26A 2D0KA 1DHIA 4LAGX 4QLGA 1RA1A 2W3BA 4G95A 1AO8A 1DLSA 1M7AA 3NU0A 5HQYA 5U27A 1RD7A 4P3RA 1KMSA 4OR7A 3QFXA 3INVA 1RB2A 3FRBX 3DL5A 1RX4A 3NZCX 4H95A 1YHOA 1DRAA 2GD9A 3SQYX 1VJ3A 3S9UA 4KL9A 1RF7A 2OBCA 3JVXA 3FY8X 2LF1A 4KJJA 4PTJA 1RH3A 3JW5A 3TQ9A 4XRBA 4M7VA 2B3ZA 3FQVA 1LUDA 5JA3A 3TQBA 4ELBA 1DF7A 2W3MA 1RE7A 3TQ8A 4GH8A 4XT7A 1RB3A 4KLXA 1IA3A 4XECX 4XE6X 3DL6A 4G3MA 3QGTA 3UM8A 1MVTA 2BLBA 4PDJA 3F0QX 3EEJA 1HFQA 3KY8A 3IA4A 3F91A 3GHVA 3F8YA 4QHVA 3SRQX 3D84X 3GI2A 7DFRA 3F0XX 3FRFX 3VCOA 3DAUA 3JWFA 2G6VA 3RO9A 4HOEA 2BL9A 3TD8A 3FYVX 3QL3A 4Q0EA 4RGCA 1DR1A 2W9SA 1AOEA 1PD9A 4HA7A 3KGYA 1RX2A 3NXOA 3QYOA 3FQZA 1DHJA 4FGHA 2BLCA 3E0BA 3NZ9X 2QK8A 1DISA 1DREA 1DR7A 4KJLA 1RG7A 3K2HA 3OCHA 3UM6A 3SRSX 1IA1A 5HF0X 4M2XA 1S3WA 2CD2A 1PDBA 3DGAA 3L3RA 4PSYA 4XT5A 3SRUX 1DIUA 1RX8A 3F0BX 4IXED 4QLEA 4I13A 5CCCA 3IRNA 1M79A 3SR5X 3JSUA 2HQPA 4XT8A 3NZDA 3M08A 4M6LA 3NXTA 1DYRA 3SA2A 2W9HA 4NX7A 4DDRA 4KYAA 3FL8A 3GHCA 4EJ1A 4KAKA 3FQ0A 2ZZAA 3FY9X 3QYLA 1DAJA 4X5IA 3NZBX 1MVSA 1J3IA 1S3UA 3OAFA 3QL0A 3LG4A 4X5FA 2INQA 2O7PA 2W3AA 1TDRA 4HA9A 2FZIA 4KBNA 1D1GA 4OSGA 2W9TA 5HVEA 4QJZD 4DPDA 1J3KA 4M6JA 4QJCA 3IX9A 4DFRA 4KJKA 1DG5A 3DRCA 4EIZA 2W3VA 1RX6A 5HF2X 2W9GA 1AI9A 1U72A 5HT5A 3ROAA 3F0UX 3KFYA 1JOLA 1IA2A 2HM9A 4TU5X 1DG8A 3QLWA 3SGYA 3Q1HA 1S3VA 3IA5A 3N0HA 1DHFA 2L28A 1DLRA 1VDRA 4KNEA 1OHKA 3NZ6X 1M78A 4XT4A 3F0SX 5CC9A 4CD2A 2W3WA 3S7AA 2BLAA 3IROA 2KGKA 4XT6A 1DR6A 3FS6A 1RX1A 6DFRA 4FHBA 1ZDRA 3JWMA 5FDAA 4ELGA 3GYFA 4G8ZX 8DFRA 5HQZA 1E26A 2JYBA 5E8QA 3I8AX 4X5HA 1DYHA 1RA2A 3EELA 1DR4A 1QZFA 5ECXA 4I1NA 3EEMA 1PD8A 1DYJA
chains in the Genus database with same CATH superfamily
2P4GA 4ELEA 1JOMA 3CD2A 4LAHX 1HFPA 5EAJA 3CL9A 4HOFA 2D5NA 2FZJA 4KM2A 4ELFA 3IRMA 5HSRA 1DR3A 4KEBA 4HOGA 4KD7A 5HT4A 2C2TA 3HBBA 3FREX 3I3RA 3DATA 3SRRX 3QLZA 5HI6A 4DP3A 4PSTA 1RA8A 3FL9A 3NXYA 2ANQA 4Q0DA 1RX3A 3NTZA 4QLFA 3KJRA 4P3QA 4ECKA 3FRDX 1SEJA 3NXVA 3R33A 1OHJA 3HJ3A 3ZPGA 3QG2A 5HUIA 3NXXA 1DR2A 5HVBA 4IXGX 2OIPA 3JTWA 4PSSA 1IA4A 3NXRA 1DDRA 4PTHA 4QI9A 1DRHA 5DXVA 1LY3A 3JWCA 1BOZA 3FRAX 4NX6A 3NZAX 4P66A 1CZ3A 3K74A 4H98A 4H96A 3NRRA 2DHFA 1S3YA 3KJSA 3JWKA 4FGGA 3CSEA 4M6KA 3K45A 2XW7A 1DRBA 2FZHA 3QLSA 3FQCA 5HPBA 3FYWX 5HSUA 3FQOA 2C2SA 4IXFX 5ECCA 1J3JA 3TQAA 1DYIA 2ITHA 3DG8A 5DFRA 1KMVA 1RX5A 1RX7A 4X5GA 1RX9A 4KY4A 1RA9A 2CIGA 2AZNA 3ZPCA 1CD2A 1JUVA 3UM5A 1DDSA 1HFRA 2ANOA 3JW3A 2H2QA 4KM0A 3FQFA 1U70A 3EIGA 4KFJA 4H97A 1U71A 3QLYA 4ELHA 4KY8A 2DRCA 3CLBA 4X5JA 1DRFA 3S3VA 5JG0X 3K47A 3DFRA 4Q6AA 1DG7A 3F8ZA 4Q67A 3SAIA 4M7UA 3QLRA 3SRWX 1LY4A 4DPHA 4EILA 3SA1A 3SH2A 1RC4A 3M09A 2HXVA 1DR5A 3EEKA 3RG9A 4LAEX 3D80A 3QLXA 4P68A 1KLKA 4LEKX 4EIGA 1BZFA 3F0VX 1RA3A 3GHWA 3EX8A 5U26A 2D0KA 1DHIA 4LAGX 4QLGA 1RA1A 2W3BA 4G95A 1AO8A 1DLSA 1M7AA 3NU0A 5HQYA 5U27A 1RD7A 4P3RA 1KMSA 4OR7A 3QFXA 3INVA 1RB2A 3FRBX 3DL5A 1RX4A 3NZCX 4H95A 1YHOA 1DRAA 2GD9A 3SQYX 1VJ3A 3S9UA 4KL9A 1RF7A 2OBCA 3JVXA 3FY8X 2LF1A 4KJJA 4PTJA 1RH3A 3JW5A 3TQ9A 4XRBA 4M7VA 2B3ZA 3FQVA 1LUDA 5JA3A 3TQBA 4ELBA 1DF7A 2W3MA 1RE7A 3TQ8A 4GH8A 4XT7A 1RB3A 4KLXA 1IA3A 4XECX 4XE6X 3DL6A 4G3MA 3QGTA 3UM8A 1MVTA 2BLBA 4PDJA 3F0QX 3EEJA 1HFQA 3KY8A 3IA4A 3F91A 3GHVA 3F8YA 4QHVA 3SRQX 3D84X 3GI2A 7DFRA 3F0XX 3FRFX 3VCOA 3DAUA 3JWFA 2G6VA 3RO9A 4HOEA 2BL9A 3TD8A 3FYVX 3QL3A 4Q0EA 4RGCA 1DR1A 2W9SA 1AOEA 1PD9A 4HA7A 3KGYA 1RX2A 3NXOA 3QYOA 3FQZA 1DHJA 4FGHA 2BLCA 3E0BA 3NZ9X 2QK8A 1DISA 1DREA 1DR7A 4KJLA 1RG7A 3K2HA 3OCHA 3UM6A 3SRSX 1IA1A 5HF0X 4M2XA 1S3WA 2CD2A 1PDBA 3DGAA 3L3RA 4PSYA 4XT5A 3SRUX 1DIUA 1RX8A 3F0BX 4IXED 4QLEA 4I13A 5CCCA 3IRNA 1M79A 3SR5X 3JSUA 2HQPA 4XT8A 3NZDA 3M08A 4M6LA 3NXTA 1DYRA 3SA2A 2W9HA 4NX7A 4DDRA 4KYAA 3FL8A 3GHCA 4EJ1A 4KAKA 3FQ0A 2ZZAA 3FY9X 3QYLA 1DAJA 4X5IA 3NZBX 1MVSA 1J3IA 1S3UA 3OAFA 3QL0A 3LG4A 4X5FA 2INQA 2O7PA 2W3AA 1TDRA 4HA9A 2FZIA 4KBNA 1D1GA 4OSGA 2W9TA 5HVEA 4QJZD 4DPDA 1J3KA 4M6JA 4QJCA 3IX9A 4DFRA 4KJKA 1DG5A 3DRCA 4EIZA 2W3VA 1RX6A 5HF2X 2W9GA 1AI9A 1U72A 5HT5A 3ROAA 3F0UX 3KFYA 1JOLA 1IA2A 2HM9A 4TU5X 1DG8A 3QLWA 3SGYA 3Q1HA 1S3VA 3IA5A 3N0HA 1DHFA 2L28A 1DLRA 1VDRA 4KNEA 1OHKA 3NZ6X 1M78A 4XT4A 3F0SX 5CC9A 4CD2A 2W3WA 3S7AA 2BLAA 3IROA 2KGKA 4XT6A 1DR6A 3FS6A 1RX1A 6DFRA 4FHBA 1ZDRA 3JWMA 5FDAA 4ELGA 3GYFA 4G8ZX 8DFRA 5HQZA 1E26A 2JYBA 5E8QA 3I8AX 4X5HA 1DYHA 1RA2A 3EELA 1DR4A 1QZFA 5ECXA 4I1NA 3EEMA 1PD8A 1DYJA
chains in the Genus database with same CATH topology
2P4GA 4ELEA 1JOMA 3CD2A 4LAHX 1HFPA 5EAJA 3CL9A 4HOFA 2D5NA 2FZJA 4KM2A 4ELFA 3IRMA 5HSRA 1DR3A 4KEBA 4HOGA 4KD7A 5HT4A 2C2TA 3HBBA 3FREX 3I3RA 3DATA 3SRRX 3QLZA 5HI6A 4DP3A 4PSTA 1RA8A 3FL9A 3NXYA 2ANQA 4Q0DA 1RX3A 3NTZA 4QLFA 3KJRA 4P3QA 4ECKA 3FRDX 1SEJA 3NXVA 3R33A 1OHJA 3HJ3A 3ZPGA 3QG2A 5HUIA 3NXXA 1DR2A 5HVBA 4IXGX 2OIPA 3JTWA 4PSSA 1IA4A 3NXRA 1DDRA 4PTHA 4QI9A 1DRHA 5DXVA 1LY3A 3JWCA 1BOZA 3FRAX 4NX6A 3NZAX 4P66A 1CZ3A 3K74A 4H98A 4H96A 3NRRA 2DHFA 1S3YA 3KJSA 3JWKA 4FGGA 3CSEA 4M6KA 3K45A 2XW7A 1DRBA 2FZHA 3QLSA 3FQCA 5HPBA 3FYWX 5HSUA 3FQOA 2C2SA 4IXFX 5ECCA 1J3JA 3TQAA 1DYIA 2ITHA 3DG8A 5DFRA 1KMVA 1RX5A 1RX7A 4X5GA 1RX9A 4KY4A 1RA9A 2CIGA 2AZNA 3ZPCA 1CD2A 1JUVA 3UM5A 1DDSA 1HFRA 2ANOA 3JW3A 2H2QA 4KM0A 3FQFA 1U70A 3EIGA 4KFJA 4H97A 1U71A 3QLYA 4ELHA 4KY8A 2DRCA 3CLBA 4X5JA 1DRFA 3S3VA 5JG0X 3K47A 3DFRA 4Q6AA 1DG7A 3F8ZA 4Q67A 3SAIA 4M7UA 3QLRA 3SRWX 1LY4A 4DPHA 4EILA 3SA1A 3SH2A 1RC4A 3M09A 2HXVA 1DR5A 3EEKA 3RG9A 4LAEX 3D80A 3QLXA 4P68A 1KLKA 4LEKX 4EIGA 1BZFA 3F0VX 1RA3A 3GHWA 3EX8A 5U26A 2D0KA 1DHIA 4LAGX 4QLGA 1RA1A 2W3BA 4G95A 1AO8A 1DLSA 1M7AA 3NU0A 5HQYA 5U27A 1RD7A 4P3RA 1KMSA 4OR7A 3QFXA 3INVA 1RB2A 3FRBX 3DL5A 1RX4A 3NZCX 4H95A 1YHOA 1DRAA 2GD9A 3SQYX 1VJ3A 3S9UA 4KL9A 1RF7A 2OBCA 3JVXA 3FY8X 2LF1A 4KJJA 4PTJA 1RH3A 3JW5A 3TQ9A 4XRBA 4M7VA 2B3ZA 3FQVA 1LUDA 5JA3A 3TQBA 4ELBA 1DF7A 2W3MA 1RE7A 3TQ8A 4GH8A 4XT7A 1RB3A 4KLXA 1IA3A 4XECX 4XE6X 3DL6A 4G3MA 3QGTA 3UM8A 1MVTA 2BLBA 4PDJA 3F0QX 3EEJA 1HFQA 3KY8A 3IA4A 3F91A 3GHVA 3F8YA 4QHVA 3SRQX 3D84X 3GI2A 7DFRA 3F0XX 3FRFX 3VCOA 3DAUA 3JWFA 2G6VA 3RO9A 4HOEA 2BL9A 3TD8A 3FYVX 3QL3A 4Q0EA 4RGCA 1DR1A 2W9SA 1AOEA 1PD9A 4HA7A 3KGYA 1RX2A 3NXOA 3QYOA 3FQZA 1DHJA 4FGHA 2BLCA 3E0BA 3NZ9X 2QK8A 1DISA 1DREA 1DR7A 4KJLA 1RG7A 3K2HA 3OCHA 3UM6A 3SRSX 1IA1A 5HF0X 4M2XA 1S3WA 2CD2A 1PDBA 3DGAA 3L3RA 4PSYA 4XT5A 3SRUX 1DIUA 1RX8A 3F0BX 4IXED 4QLEA 4I13A 5CCCA 3IRNA 1M79A 3SR5X 3JSUA 2HQPA 4XT8A 3NZDA 3M08A 4M6LA 3NXTA 1DYRA 3SA2A 2W9HA 4NX7A 4DDRA 4KYAA 3FL8A 3GHCA 4EJ1A 4KAKA 3FQ0A 2ZZAA 3FY9X 3QYLA 1DAJA 4X5IA 3NZBX 1MVSA 1J3IA 1S3UA 3OAFA 3QL0A 3LG4A 4X5FA 2INQA 2O7PA 2W3AA 1TDRA 4HA9A 2FZIA 4KBNA 1D1GA 4OSGA 2W9TA 5HVEA 4QJZD 4DPDA 1J3KA 4M6JA 4QJCA 3IX9A 4DFRA 4KJKA 1DG5A 3DRCA 4EIZA 2W3VA 1RX6A 5HF2X 2W9GA 1AI9A 1U72A 5HT5A 3ROAA 3F0UX 3KFYA 1JOLA 1IA2A 2HM9A 4TU5X 1DG8A 3QLWA 3SGYA 3Q1HA 1S3VA 3IA5A 3N0HA 1DHFA 2L28A 1DLRA 1VDRA 4KNEA 1OHKA 3NZ6X 1M78A 4XT4A 3F0SX 5CC9A 4CD2A 2W3WA 3S7AA 2BLAA 3IROA 2KGKA 4XT6A 1DR6A 3FS6A 1RX1A 6DFRA 4FHBA 1ZDRA 3JWMA 5FDAA 4ELGA 3GYFA 4G8ZX 8DFRA 5HQZA 1E26A 2JYBA 5E8QA 3I8AX 4X5HA 1DYHA 1RA2A 3EELA 1DR4A 1QZFA 5ECXA 4I1NA 3EEMA 1PD8A 1DYJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2P4G A;  4ELE A;  1JOM A;  3CD2 A;  4LAH X;  1HFP A;  5EAJ A;  3CL9 A;  4HOF A;  2D5N A;  2FZJ A;  4KM2 A;  4ELF A;  3IRM A;  5HSR A;  1DR3 A;  4KEB A;  4HOG A;  4KD7 A;  5HT4 A;  2C2T A;  3HBB A;  3FRE X;  3I3R A;  3DAT A;  3SRR X;  3QLZ A;  5HI6 A;  4DP3 A;  4PST A;  1RA8 A;  3FL9 A;  3NXY A;  2ANQ A;  4Q0D A;  1RX3 A;  3NTZ A;  4QLF A;  3KJR A;  4P3Q A;  4ECK A;  3FRD X;  1SEJ A;  3NXV A;  3R33 A;  1OHJ A;  3HJ3 A;  3ZPG A;  3QG2 A;  5HUI A;  3NXX A;  1DR2 A;  5HVB A;  4IXG X;  2OIP A;  3JTW A;  4PSS A;  1IA4 A;  3NXR A;  1DDR A;  4PTH A;  4QI9 A;  1DRH A;  5DXV A;  1LY3 A;  3JWC A;  1BOZ A;  3FRA X;  4NX6 A;  3NZA X;  4P66 A;  1CZ3 A;  3K74 A;  4H98 A;  4H96 A;  3NRR A;  2DHF A;  1S3Y A;  3KJS A;  3JWK A;  4FGG A;  3CSE A;  4M6K A;  3K45 A;  2XW7 A;  1DRB A;  2FZH A;  3QLS A;  3FQC A;  5HPB A;  3FYW X;  5HSU A;  3FQO A;  2C2S A;  4IXF X;  5ECC A;  1J3J A;  3TQA A;  1DYI A;  2ITH A;  3DG8 A;  5DFR A;  1KMV A;  1RX5 A;  1RX7 A;  4X5G A;  1RX9 A;  4KY4 A;  1RA9 A;  2CIG A;  2AZN A;  3ZPC A;  1CD2 A;  1JUV A;  3UM5 A;  1DDS A;  1HFR A;  2ANO A;  3JW3 A;  2H2Q A;  4KM0 A;  3FQF A;  1U70 A;  3EIG A;  4KFJ A;  4H97 A;  1U71 A;  3QLY A;  4ELH A;  4KY8 A;  2DRC A;  3CLB A;  4X5J A;  1DRF A;  3S3V A;  5JG0 X;  3K47 A;  3DFR A;  4Q6A A;  1DG7 A;  3F8Z A;  4Q67 A;  3SAI A;  4M7U A;  3QLR A;  3SRW X;  1LY4 A;  4DPH A;  4EIL A;  3SA1 A;  3SH2 A;  1RC4 A;  3M09 A;  2HXV A;  1DR5 A;  3EEK A;  3RG9 A;  4LAE X;  3D80 A;  3QLX A;  4P68 A;  1KLK A;  4LEK X;  4EIG A;  1BZF A;  3F0V X;  1RA3 A;  3GHW A;  3EX8 A;  5U26 A;  2D0K A;  1DHI A;  4LAG X;  4QLG A;  1RA1 A;  2W3B A;  4G95 A;  1AO8 A;  1DLS A;  1M7A A;  3NU0 A;  5HQY A;  5U27 A;  1RD7 A;  4P3R A;  1KMS A;  4OR7 A;  3QFX A;  3INV A;  1RB2 A;  3FRB X;  3DL5 A;  1RX4 A;  3NZC X;  4H95 A;  1YHO A;  1DRA A;  2GD9 A;  3SQY X;  1VJ3 A;  3S9U A;  4KL9 A;  1RF7 A;  2OBC A;  3JVX A;  3FY8 X;  2LF1 A;  4KJJ A;  4PTJ A;  1RH3 A;  3JW5 A;  3TQ9 A;  4XRB A;  4M7V A;  2B3Z A;  3FQV A;  1LUD A;  5JA3 A;  3TQB A;  4ELB A;  1DF7 A;  2W3M A;  1RE7 A;  3TQ8 A;  4GH8 A;  4XT7 A;  1RB3 A;  4KLX A;  1IA3 A;  4XEC X;  4XE6 X;  3DL6 A;  4G3M A;  3QGT A;  3UM8 A;  1MVT A;  2BLB A;  4PDJ A;  3F0Q X;  3EEJ A;  1HFQ A;  3KY8 A;  3IA4 A;  3F91 A;  3GHV A;  3F8Y A;  4QHV A;  3SRQ X;  3D84 X;  3GI2 A;  7DFR A;  3F0X X;  3FRF X;  3VCO A;  3DAU A;  3JWF A;  2G6V A;  3RO9 A;  4HOE A;  2BL9 A;  3TD8 A;  3FYV X;  3QL3 A;  4Q0E A;  4RGC A;  1DR1 A;  2W9S A;  1AOE A;  1PD9 A;  4HA7 A;  3KGY A;  1RX2 A;  3NXO A;  3QYO A;  3FQZ A;  1DHJ A;  4FGH A;  2BLC A;  3E0B A;  3NZ9 X;  2QK8 A;  1DIS A;  1DRE A;  1DR7 A;  4KJL A;  1RG7 A;  3K2H A;  3OCH A;  3UM6 A;  3SRS X;  1IA1 A;  5HF0 X;  4M2X A;  1S3W A;  2CD2 A;  1PDB A;  3DGA A;  3L3R A;  4PSY A;  4XT5 A;  3SRU X;  1DIU A;  1RX8 A;  3F0B X;  4IXE D;  4QLE A;  4I13 A;  5CCC A;  3IRN A;  1M79 A;  3SR5 X;  3JSU A;  2HQP A;  4XT8 A;  3NZD A;  3M08 A;  4M6L A;  3NXT A;  1DYR A;  3SA2 A;  2W9H A;  4NX7 A;  4DDR A;  4KYA A;  3FL8 A;  3GHC A;  4EJ1 A;  4KAK A;  3FQ0 A;  2ZZA A;  3FY9 X;  3QYL A;  1DAJ A;  4X5I A;  3NZB X;  1MVS A;  1J3I A;  1S3U A;  3OAF A;  3QL0 A;  3LG4 A;  4X5F A;  2INQ A;  2O7P A;  2W3A A;  1TDR A;  4HA9 A;  2FZI A;  4KBN A;  1D1G A;  4OSG A;  2W9T A;  5HVE A;  4QJZ D;  4DPD A;  1J3K A;  4M6J A;  4QJC A;  3IX9 A;  4DFR A;  4KJK A;  1DG5 A;  3DRC A;  4EIZ A;  2W3V A;  1RX6 A;  5HF2 X;  2W9G A;  1AI9 A;  1U72 A;  5HT5 A;  3ROA A;  3F0U X;  3KFY A;  1JOL A;  1IA2 A;  2HM9 A;  4TU5 X;  1DG8 A;  3QLW A;  3SGY A;  3Q1H A;  1S3V A;  3IA5 A;  3N0H A;  1DHF A;  2L28 A;  1DLR A;  1VDR A;  4KNE A;  1OHK A;  3NZ6 X;  1M78 A;  4XT4 A;  3F0S X;  5CC9 A;  4CD2 A;  2W3W A;  3S7A A;  2BLA A;  3IRO A;  2KGK A;  4XT6 A;  1DR6 A;  3FS6 A;  1RX1 A;  6DFR A;  4FHB A;  1ZDR A;  3JWM A;  5FDA A;  4ELG A;  3GYF A;  4G8Z X;  8DFR A;  5HQZ A;  1E26 A;  2JYB A;  5E8Q A;  3I8A X;  4X5H A;  1DYH A;  1RA2 A;  3EEL A;  1DR4 A;  1QZF A;  5ECX A;  4I1N A;  3EEM A;  1PD8 A;  1DYJ A; 
#chains in the Genus database with same CATH topology
 2P4G A;  4ELE A;  1JOM A;  3CD2 A;  4LAH X;  1HFP A;  5EAJ A;  3CL9 A;  4HOF A;  2D5N A;  2FZJ A;  4KM2 A;  4ELF A;  3IRM A;  5HSR A;  1DR3 A;  4KEB A;  4HOG A;  4KD7 A;  5HT4 A;  2C2T A;  3HBB A;  3FRE X;  3I3R A;  3DAT A;  3SRR X;  3QLZ A;  5HI6 A;  4DP3 A;  4PST A;  1RA8 A;  3FL9 A;  3NXY A;  2ANQ A;  4Q0D A;  1RX3 A;  3NTZ A;  4QLF A;  3KJR A;  4P3Q A;  4ECK A;  3FRD X;  1SEJ A;  3NXV A;  3R33 A;  1OHJ A;  3HJ3 A;  3ZPG A;  3QG2 A;  5HUI A;  3NXX A;  1DR2 A;  5HVB A;  4IXG X;  2OIP A;  3JTW A;  4PSS A;  1IA4 A;  3NXR A;  1DDR A;  4PTH A;  4QI9 A;  1DRH A;  5DXV A;  1LY3 A;  3JWC A;  1BOZ A;  3FRA X;  4NX6 A;  3NZA X;  4P66 A;  1CZ3 A;  3K74 A;  4H98 A;  4H96 A;  3NRR A;  2DHF A;  1S3Y A;  3KJS A;  3JWK A;  4FGG A;  3CSE A;  4M6K A;  3K45 A;  2XW7 A;  1DRB A;  2FZH A;  3QLS A;  3FQC A;  5HPB A;  3FYW X;  5HSU A;  3FQO A;  2C2S A;  4IXF X;  5ECC A;  1J3J A;  3TQA A;  1DYI A;  2ITH A;  3DG8 A;  5DFR A;  1KMV A;  1RX5 A;  1RX7 A;  4X5G A;  1RX9 A;  4KY4 A;  1RA9 A;  2CIG A;  2AZN A;  3ZPC A;  1CD2 A;  1JUV A;  3UM5 A;  1DDS A;  1HFR A;  2ANO A;  3JW3 A;  2H2Q A;  4KM0 A;  3FQF A;  1U70 A;  3EIG A;  4KFJ A;  4H97 A;  1U71 A;  3QLY A;  4ELH A;  4KY8 A;  2DRC A;  3CLB A;  4X5J A;  1DRF A;  3S3V A;  5JG0 X;  3K47 A;  3DFR A;  4Q6A A;  1DG7 A;  3F8Z A;  4Q67 A;  3SAI A;  4M7U A;  3QLR A;  3SRW X;  1LY4 A;  4DPH A;  4EIL A;  3SA1 A;  3SH2 A;  1RC4 A;  3M09 A;  2HXV A;  1DR5 A;  3EEK A;  3RG9 A;  4LAE X;  3D80 A;  3QLX A;  4P68 A;  1KLK A;  4LEK X;  4EIG A;  1BZF A;  3F0V X;  1RA3 A;  3GHW A;  3EX8 A;  5U26 A;  2D0K A;  1DHI A;  4LAG X;  4QLG A;  1RA1 A;  2W3B A;  4G95 A;  1AO8 A;  1DLS A;  1M7A A;  3NU0 A;  5HQY A;  5U27 A;  1RD7 A;  4P3R A;  1KMS A;  4OR7 A;  3QFX A;  3INV A;  1RB2 A;  3FRB X;  3DL5 A;  1RX4 A;  3NZC X;  4H95 A;  1YHO A;  1DRA A;  2GD9 A;  3SQY X;  1VJ3 A;  3S9U A;  4KL9 A;  1RF7 A;  2OBC A;  3JVX A;  3FY8 X;  2LF1 A;  4KJJ A;  4PTJ A;  1RH3 A;  3JW5 A;  3TQ9 A;  4XRB A;  4M7V A;  2B3Z A;  3FQV A;  1LUD A;  5JA3 A;  3TQB A;  4ELB A;  1DF7 A;  2W3M A;  1RE7 A;  3TQ8 A;  4GH8 A;  4XT7 A;  1RB3 A;  4KLX A;  1IA3 A;  4XEC X;  4XE6 X;  3DL6 A;  4G3M A;  3QGT A;  3UM8 A;  1MVT A;  2BLB A;  4PDJ A;  3F0Q X;  3EEJ A;  1HFQ A;  3KY8 A;  3IA4 A;  3F91 A;  3GHV A;  3F8Y A;  4QHV A;  3SRQ X;  3D84 X;  3GI2 A;  7DFR A;  3F0X X;  3FRF X;  3VCO A;  3DAU A;  3JWF A;  2G6V A;  3RO9 A;  4HOE A;  2BL9 A;  3TD8 A;  3FYV X;  3QL3 A;  4Q0E A;  4RGC A;  1DR1 A;  2W9S A;  1AOE A;  1PD9 A;  4HA7 A;  3KGY A;  1RX2 A;  3NXO A;  3QYO A;  3FQZ A;  1DHJ A;  4FGH A;  2BLC A;  3E0B A;  3NZ9 X;  2QK8 A;  1DIS A;  1DRE A;  1DR7 A;  4KJL A;  1RG7 A;  3K2H A;  3OCH A;  3UM6 A;  3SRS X;  1IA1 A;  5HF0 X;  4M2X A;  1S3W A;  2CD2 A;  1PDB A;  3DGA A;  3L3R A;  4PSY A;  4XT5 A;  3SRU X;  1DIU A;  1RX8 A;  3F0B X;  4IXE D;  4QLE A;  4I13 A;  5CCC A;  3IRN A;  1M79 A;  3SR5 X;  3JSU A;  2HQP A;  4XT8 A;  3NZD A;  3M08 A;  4M6L A;  3NXT A;  1DYR A;  3SA2 A;  2W9H A;  4NX7 A;  4DDR A;  4KYA A;  3FL8 A;  3GHC A;  4EJ1 A;  4KAK A;  3FQ0 A;  2ZZA A;  3FY9 X;  3QYL A;  1DAJ A;  4X5I A;  3NZB X;  1MVS A;  1J3I A;  1S3U A;  3OAF A;  3QL0 A;  3LG4 A;  4X5F A;  2INQ A;  2O7P A;  2W3A A;  1TDR A;  4HA9 A;  2FZI A;  4KBN A;  1D1G A;  4OSG A;  2W9T A;  5HVE A;  4QJZ D;  4DPD A;  1J3K A;  4M6J A;  4QJC A;  3IX9 A;  4DFR A;  4KJK A;  1DG5 A;  3DRC A;  4EIZ A;  2W3V A;  1RX6 A;  5HF2 X;  2W9G A;  1AI9 A;  1U72 A;  5HT5 A;  3ROA A;  3F0U X;  3KFY A;  1JOL A;  1IA2 A;  2HM9 A;  4TU5 X;  1DG8 A;  3QLW A;  3SGY A;  3Q1H A;  1S3V A;  3IA5 A;  3N0H A;  1DHF A;  2L28 A;  1DLR A;  1VDR A;  4KNE A;  1OHK A;  3NZ6 X;  1M78 A;  4XT4 A;  3F0S X;  5CC9 A;  4CD2 A;  2W3W A;  3S7A A;  2BLA A;  3IRO A;  2KGK A;  4XT6 A;  1DR6 A;  3FS6 A;  1RX1 A;  6DFR A;  4FHB A;  1ZDR A;  3JWM A;  5FDA A;  4ELG A;  3GYF A;  4G8Z X;  8DFR A;  5HQZ A;  1E26 A;  2JYB A;  5E8Q A;  3I8A X;  4X5H A;  1DYH A;  1RA2 A;  3EEL A;  1DR4 A;  1QZF A;  5ECX A;  4I1N A;  3EEM A;  1PD8 A;  1DYJ A; 
#chains in the Genus database with same CATH homology
 2P4G A;  4ELE A;  1JOM A;  3CD2 A;  4LAH X;  1HFP A;  5EAJ A;  3CL9 A;  4HOF A;  2D5N A;  2FZJ A;  4KM2 A;  4ELF A;  3IRM A;  5HSR A;  1DR3 A;  4KEB A;  4HOG A;  4KD7 A;  5HT4 A;  2C2T A;  3HBB A;  3FRE X;  3I3R A;  3DAT A;  3SRR X;  3QLZ A;  5HI6 A;  4DP3 A;  4PST A;  1RA8 A;  3FL9 A;  3NXY A;  2ANQ A;  4Q0D A;  1RX3 A;  3NTZ A;  4QLF A;  3KJR A;  4P3Q A;  4ECK A;  3FRD X;  1SEJ A;  3NXV A;  3R33 A;  1OHJ A;  3HJ3 A;  3ZPG A;  3QG2 A;  5HUI A;  3NXX A;  1DR2 A;  5HVB A;  4IXG X;  2OIP A;  3JTW A;  4PSS A;  1IA4 A;  3NXR A;  1DDR A;  4PTH A;  4QI9 A;  1DRH A;  5DXV A;  1LY3 A;  3JWC A;  1BOZ A;  3FRA X;  4NX6 A;  3NZA X;  4P66 A;  1CZ3 A;  3K74 A;  4H98 A;  4H96 A;  3NRR A;  2DHF A;  1S3Y A;  3KJS A;  3JWK A;  4FGG A;  3CSE A;  4M6K A;  3K45 A;  2XW7 A;  1DRB A;  2FZH A;  3QLS A;  3FQC A;  5HPB A;  3FYW X;  5HSU A;  3FQO A;  2C2S A;  4IXF X;  5ECC A;  1J3J A;  3TQA A;  1DYI A;  2ITH A;  3DG8 A;  5DFR A;  1KMV A;  1RX5 A;  1RX7 A;  4X5G A;  1RX9 A;  4KY4 A;  1RA9 A;  2CIG A;  2AZN A;  3ZPC A;  1CD2 A;  1JUV A;  3UM5 A;  1DDS A;  1HFR A;  2ANO A;  3JW3 A;  2H2Q A;  4KM0 A;  3FQF A;  1U70 A;  3EIG A;  4KFJ A;  4H97 A;  1U71 A;  3QLY A;  4ELH A;  4KY8 A;  2DRC A;  3CLB A;  4X5J A;  1DRF A;  3S3V A;  5JG0 X;  3K47 A;  3DFR A;  4Q6A A;  1DG7 A;  3F8Z A;  4Q67 A;  3SAI A;  4M7U A;  3QLR A;  3SRW X;  1LY4 A;  4DPH A;  4EIL A;  3SA1 A;  3SH2 A;  1RC4 A;  3M09 A;  2HXV A;  1DR5 A;  3EEK A;  3RG9 A;  4LAE X;  3D80 A;  3QLX A;  4P68 A;  1KLK A;  4LEK X;  4EIG A;  1BZF A;  3F0V X;  1RA3 A;  3GHW A;  3EX8 A;  5U26 A;  2D0K A;  1DHI A;  4LAG X;  4QLG A;  1RA1 A;  2W3B A;  4G95 A;  1AO8 A;  1DLS A;  1M7A A;  3NU0 A;  5HQY A;  5U27 A;  1RD7 A;  4P3R A;  1KMS A;  4OR7 A;  3QFX A;  3INV A;  1RB2 A;  3FRB X;  3DL5 A;  1RX4 A;  3NZC X;  4H95 A;  1YHO A;  1DRA A;  2GD9 A;  3SQY X;  1VJ3 A;  3S9U A;  4KL9 A;  1RF7 A;  2OBC A;  3JVX A;  3FY8 X;  2LF1 A;  4KJJ A;  4PTJ A;  1RH3 A;  3JW5 A;  3TQ9 A;  4XRB A;  4M7V A;  2B3Z A;  3FQV A;  1LUD A;  5JA3 A;  3TQB A;  4ELB A;  1DF7 A;  2W3M A;  1RE7 A;  3TQ8 A;  4GH8 A;  4XT7 A;  1RB3 A;  4KLX A;  1IA3 A;  4XEC X;  4XE6 X;  3DL6 A;  4G3M A;  3QGT A;  3UM8 A;  1MVT A;  2BLB A;  4PDJ A;  3F0Q X;  3EEJ A;  1HFQ A;  3KY8 A;  3IA4 A;  3F91 A;  3GHV A;  3F8Y A;  4QHV A;  3SRQ X;  3D84 X;  3GI2 A;  7DFR A;  3F0X X;  3FRF X;  3VCO A;  3DAU A;  3JWF A;  2G6V A;  3RO9 A;  4HOE A;  2BL9 A;  3TD8 A;  3FYV X;  3QL3 A;  4Q0E A;  4RGC A;  1DR1 A;  2W9S A;  1AOE A;  1PD9 A;  4HA7 A;  3KGY A;  1RX2 A;  3NXO A;  3QYO A;  3FQZ A;  1DHJ A;  4FGH A;  2BLC A;  3E0B A;  3NZ9 X;  2QK8 A;  1DIS A;  1DRE A;  1DR7 A;  4KJL A;  1RG7 A;  3K2H A;  3OCH A;  3UM6 A;  3SRS X;  1IA1 A;  5HF0 X;  4M2X A;  1S3W A;  2CD2 A;  1PDB A;  3DGA A;  3L3R A;  4PSY A;  4XT5 A;  3SRU X;  1DIU A;  1RX8 A;  3F0B X;  4IXE D;  4QLE A;  4I13 A;  5CCC A;  3IRN A;  1M79 A;  3SR5 X;  3JSU A;  2HQP A;  4XT8 A;  3NZD A;  3M08 A;  4M6L A;  3NXT A;  1DYR A;  3SA2 A;  2W9H A;  4NX7 A;  4DDR A;  4KYA A;  3FL8 A;  3GHC A;  4EJ1 A;  4KAK A;  3FQ0 A;  2ZZA A;  3FY9 X;  3QYL A;  1DAJ A;  4X5I A;  3NZB X;  1MVS A;  1J3I A;  1S3U A;  3OAF A;  3QL0 A;  3LG4 A;  4X5F A;  2INQ A;  2O7P A;  2W3A A;  1TDR A;  4HA9 A;  2FZI A;  4KBN A;  1D1G A;  4OSG A;  2W9T A;  5HVE A;  4QJZ D;  4DPD A;  1J3K A;  4M6J A;  4QJC A;  3IX9 A;  4DFR A;  4KJK A;  1DG5 A;  3DRC A;  4EIZ A;  2W3V A;  1RX6 A;  5HF2 X;  2W9G A;  1AI9 A;  1U72 A;  5HT5 A;  3ROA A;  3F0U X;  3KFY A;  1JOL A;  1IA2 A;  2HM9 A;  4TU5 X;  1DG8 A;  3QLW A;  3SGY A;  3Q1H A;  1S3V A;  3IA5 A;  3N0H A;  1DHF A;  2L28 A;  1DLR A;  1VDR A;  4KNE A;  1OHK A;  3NZ6 X;  1M78 A;  4XT4 A;  3F0S X;  5CC9 A;  4CD2 A;  2W3W A;  3S7A A;  2BLA A;  3IRO A;  2KGK A;  4XT6 A;  1DR6 A;  3FS6 A;  1RX1 A;  6DFR A;  4FHB A;  1ZDR A;  3JWM A;  5FDA A;  4ELG A;  3GYF A;  4G8Z X;  8DFR A;  5HQZ A;  1E26 A;  2JYB A;  5E8Q A;  3I8A X;  4X5H A;  1DYH A;  1RA2 A;  3EEL A;  1DR4 A;  1QZF A;  5ECX A;  4I1N A;  3EEM A;  1PD8 A;  1DYJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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