3EIGA

Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase
Total Genus 49
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNERRYFERMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 49
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2008-09-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3eigA00
1DDSA 3F0SX 2DRCA 1RA1A 3UM6A 3SGYA 1BOZA 2ITHA 3FY9X 4EILA 4EIZA 1DAJA 3KGYA 4XECX 3NZ9X 4KBNA 1DRBA 3TD8A 1RX6A 3NZBX 4HOEA 1DR1A 3IROA 3QYOA 4KM2A 5HUIA 3SQYX 1RG7A 3QFXA 4HA7A 2W3WA 3UM5A 2OBCA 1RA2A 4EJ1A 1LUDA 4PSYA 2C2TA 3JWKA 5CC9A 1S3VA 4KYAA 3SRQX 5ECXA 2INQA 1M7AA 1DHJA 5U26A 4DFRA 1DRHA 3M08A 4PTJA 1DR3A 2C2SA 5HVEA 2BL9A 1DREA 1KLKA 2D0KA 4KJJA 4PTHA 1M78A 4M7VA 3F0UX 3FQVA 3FS6A 4KNEA 1HFRA 1U71A 3CSEA 3VCOA 4ECKA 3SRWX 2W3AA 3FRFX 3K2HA 3KY8A 1DHFA 4GH8A 3I8AX 3JTWA 4KLXA 4P68A 3NXYA 1DR5A 3SAIA 3JWFA 2O7PA 3JWMA 1IA4A 4Q67A 4XT5A 3FQZA 4X5FA 1LY3A 3F8ZA 3QL0A 5HQZA 1VJ3A 2D5NA 1RX5A 5HT5A 4X5GA 3R33A 3I3RA 2H2QA 3M09A 3QYLA 4X5JA 3SH2A 4G8ZX 3HJ3A 4FGHA 3F0XX 3JSUA 3ROAA 3FQFA 4KL9A 4NX7A 1M79A 3FY8X 3F0QX 5HPBA 1RB3A 3GHWA 3FYVX 3EEJA 3FRBX 4G95A 4CD2A 4P66A 2BLBA 1MVTA 3GI2A 1DYIA 3KJSA 3JW3A 3IRNA 1JUVA 4I1NA 4PSTA 3UM8A 1DRFA 3IRMA 1PD8A 2CIGA 5FDAA 3SRSX 5JG0X 1J3JA 3F0VX 4XRBA 4ELFA 4LAEX 3E0BA 5HT4A 4M2XA 1IA1A 1DR7A 3QLSA 4G3MA 4QJCA 1RX7A 4ELGA 1JOLA 3OAFA 2HXVA 3S9UA 1KMSA 5E8QA 1DRAA 4KJLA 4P3QA 3EX8A 1CZ3A 2BLCA 3ZPCA 4KEBA 3FQ0A 1RA8A 3NXOA 4LAGX 3NU0A 1CD2A 5EAJA 3RG9A 1AO8A 3FRAX 1RX3A 4QHVA 4KFJA 1HFPA 4M6JA 2ANOA 4DDRA 3EIGA 3KFYA 4X5HA 1OHKA 4XT4A 3NZ6X 1YHOA 3DRCA 5HSUA 1DR2A 1IA3A 1RE7A 5DFRA 3SRUX 3TQ9A 1RC4A 4Q0DA 4XT7A 3Q1HA 4I13A 3NXXA 2LF1A 4QLGA 1DG8A 5HI6A 5HSRA 4X5IA 2JYBA 3SRRX 3D84X 4P3RA 1RX9A 4H97A 1JOMA 3K45A 2KGKA 3FQCA 1DISA 1DHIA 3FRDX 5HVBA 3ZPGA 1DYJA 3GHCA 3DAUA 3SA2A 2QK8A 4HOFA 4IXGX 1PD9A 2CD2A 2FZIA 1RX2A 3QL3A 3SA1A 2XW7A 3S3VA 6DFRA 3DATA 4TU5X 4KAKA 4KJKA 3FYWX 4KD7A 3JWCA 1DDRA 4LAHX 3TQAA 2OIPA 1DR6A 1AI9A 4QLEA 5HF0X 1D1GA 1TDRA 3JVXA 2P4GA 4H98A 1ZDRA 2W3BA 1LY4A 1SEJA 1RH3A 3EEMA 5CCCA 1DLRA 1DF7A 3IX9A 2HM9A 3K74A 1DR4A 1DYRA 3QLWA 4DP3A 1AOEA 2W9GA 4OR7A 3IA5A 3TQBA 3SR5X 2W9TA 3S7AA 3QGTA 3QLYA 4LEKX 3OCHA 3RO9A 2B3ZA 4RGCA 2DHFA 2AZNA 3F91A 4PDJA 1KMVA 3DG8A 2W9HA 4ELHA 1PDBA 5HQYA 4XT6A 1RB2A 3DGAA 3CLBA 3NZAX 4ELEA 5ECCA 3FL8A 3QG2A 2W3VA 4FHBA 1RX1A 1DYHA 1J3IA 3EELA 4Q6AA 8DFRA 4ELBA 3INVA 4Q0EA 5U27A 1QZFA 1S3WA 3KJRA 4HOGA 4XE6X 1DG5A 1IA2A 3N0HA 3NTZA 1OHJA 3DL6A 1RD7A 5JA3A 1J3KA 2ANQA 4DPDA 2W3MA 4QJZD 3CL9A 2L28A 4M7UA 3QLXA 3GHVA 4FGGA 3NZCX 4DPHA 4H95A 3DL5A 4PSSA 3JW5A 3F0BX 4XT8A 3F8YA 1MVSA 4IXED 2FZHA 2BLAA 4OSGA 3GYFA 1RX8A 3D80A 1S3UA 1DLSA 1DG7A 2HQPA 3TQ8A 3CD2A 1U70A 4NX6A 3EEKA 3K47A 1BZFA 1RX4A 3DFRA 3FREX 3LG4A 3NZDA 4KM0A 4HA9A 1RA3A 5HF2X 3HBBA 2G6VA 3QLZA 1RF7A 3IA4A 1E26A 1RA9A 1S3YA 3FQOA 4EIGA 2FZJA 3QLRA 3NXRA 4KY4A 3L3RA 3NXTA 1VDRA 4QLFA 4M6KA 1DIUA 1U72A 3NXVA 4M6LA 4QI9A 7DFRA 1HFQA 3FL9A 2W9SA 2GD9A 4IXFX 3NRRA 2ZZAA 4KY8A 4H96A 5DXVA
chains in the Genus database with same CATH superfamily
1DDSA 3F0SX 2DRCA 1RA1A 3UM6A 3SGYA 1BOZA 2ITHA 3FY9X 4EILA 4EIZA 1DAJA 3KGYA 4XECX 3NZ9X 4KBNA 1DRBA 3TD8A 1RX6A 3NZBX 4HOEA 1DR1A 3IROA 3QYOA 4KM2A 5HUIA 3SQYX 1RG7A 3QFXA 4HA7A 2W3WA 3UM5A 2OBCA 1RA2A 4EJ1A 1LUDA 4PSYA 2C2TA 3JWKA 5CC9A 1S3VA 4KYAA 3SRQX 5ECXA 2INQA 1M7AA 1DHJA 5U26A 4DFRA 1DRHA 3M08A 4PTJA 1DR3A 2C2SA 5HVEA 2BL9A 1DREA 1KLKA 2D0KA 4KJJA 4PTHA 1M78A 4M7VA 3F0UX 3FQVA 3FS6A 4KNEA 1HFRA 1U71A 3CSEA 3VCOA 4ECKA 3SRWX 2W3AA 3FRFX 3K2HA 3KY8A 1DHFA 4GH8A 3I8AX 3JTWA 4KLXA 4P68A 3NXYA 1DR5A 3SAIA 3JWFA 2O7PA 3JWMA 1IA4A 4Q67A 4XT5A 3FQZA 4X5FA 1LY3A 3F8ZA 3QL0A 5HQZA 1VJ3A 2D5NA 1RX5A 5HT5A 4X5GA 3R33A 3I3RA 2H2QA 3M09A 3QYLA 4X5JA 3SH2A 4G8ZX 3HJ3A 4FGHA 3F0XX 3JSUA 3ROAA 3FQFA 4KL9A 4NX7A 1M79A 3FY8X 3F0QX 5HPBA 1RB3A 3GHWA 3FYVX 3EEJA 3FRBX 4G95A 4CD2A 4P66A 2BLBA 1MVTA 3GI2A 1DYIA 3KJSA 3JW3A 3IRNA 1JUVA 4I1NA 4PSTA 3UM8A 1DRFA 3IRMA 1PD8A 2CIGA 5FDAA 3SRSX 5JG0X 1J3JA 3F0VX 4XRBA 4ELFA 4LAEX 3E0BA 5HT4A 4M2XA 1IA1A 1DR7A 3QLSA 4G3MA 4QJCA 1RX7A 4ELGA 1JOLA 3OAFA 2HXVA 3S9UA 1KMSA 5E8QA 1DRAA 4KJLA 4P3QA 3EX8A 1CZ3A 2BLCA 3ZPCA 4KEBA 3FQ0A 1RA8A 3NXOA 4LAGX 3NU0A 1CD2A 5EAJA 3RG9A 1AO8A 3FRAX 1RX3A 4QHVA 4KFJA 1HFPA 4M6JA 2ANOA 4DDRA 3EIGA 3KFYA 4X5HA 1OHKA 4XT4A 3NZ6X 1YHOA 3DRCA 5HSUA 1DR2A 1IA3A 1RE7A 5DFRA 3SRUX 3TQ9A 1RC4A 4Q0DA 4XT7A 3Q1HA 4I13A 3NXXA 2LF1A 4QLGA 1DG8A 5HI6A 5HSRA 4X5IA 2JYBA 3SRRX 3D84X 4P3RA 1RX9A 4H97A 1JOMA 3K45A 2KGKA 3FQCA 1DISA 1DHIA 3FRDX 5HVBA 3ZPGA 1DYJA 3GHCA 3DAUA 3SA2A 2QK8A 4HOFA 4IXGX 1PD9A 2CD2A 2FZIA 1RX2A 3QL3A 3SA1A 2XW7A 3S3VA 6DFRA 3DATA 4TU5X 4KAKA 4KJKA 3FYWX 4KD7A 3JWCA 1DDRA 4LAHX 3TQAA 2OIPA 1DR6A 1AI9A 4QLEA 5HF0X 1D1GA 1TDRA 3JVXA 2P4GA 4H98A 1ZDRA 2W3BA 1LY4A 1SEJA 1RH3A 3EEMA 5CCCA 1DLRA 1DF7A 3IX9A 2HM9A 3K74A 1DR4A 1DYRA 3QLWA 4DP3A 1AOEA 2W9GA 4OR7A 3IA5A 3TQBA 3SR5X 2W9TA 3S7AA 3QGTA 3QLYA 4LEKX 3OCHA 3RO9A 2B3ZA 4RGCA 2DHFA 2AZNA 3F91A 4PDJA 1KMVA 3DG8A 2W9HA 4ELHA 1PDBA 5HQYA 4XT6A 1RB2A 3DGAA 3CLBA 3NZAX 4ELEA 5ECCA 3FL8A 3QG2A 2W3VA 4FHBA 1RX1A 1DYHA 1J3IA 3EELA 4Q6AA 8DFRA 4ELBA 3INVA 4Q0EA 5U27A 1QZFA 1S3WA 3KJRA 4HOGA 4XE6X 1DG5A 1IA2A 3N0HA 3NTZA 1OHJA 3DL6A 1RD7A 5JA3A 1J3KA 2ANQA 4DPDA 2W3MA 4QJZD 3CL9A 2L28A 4M7UA 3QLXA 3GHVA 4FGGA 3NZCX 4DPHA 4H95A 3DL5A 4PSSA 3JW5A 3F0BX 4XT8A 3F8YA 1MVSA 4IXED 2FZHA 2BLAA 4OSGA 3GYFA 1RX8A 3D80A 1S3UA 1DLSA 1DG7A 2HQPA 3TQ8A 3CD2A 1U70A 4NX6A 3EEKA 3K47A 1BZFA 1RX4A 3DFRA 3FREX 3LG4A 3NZDA 4KM0A 4HA9A 1RA3A 5HF2X 3HBBA 2G6VA 3QLZA 1RF7A 3IA4A 1E26A 1RA9A 1S3YA 3FQOA 4EIGA 2FZJA 3QLRA 3NXRA 4KY4A 3L3RA 3NXTA 1VDRA 4QLFA 4M6KA 1DIUA 1U72A 3NXVA 4M6LA 4QI9A 7DFRA 1HFQA 3FL9A 2W9SA 2GD9A 4IXFX 3NRRA 2ZZAA 4KY8A 4H96A 5DXVA
chains in the Genus database with same CATH topology
1DDSA 3F0SX 2DRCA 1RA1A 3UM6A 3SGYA 1BOZA 2ITHA 3FY9X 4EILA 4EIZA 1DAJA 3KGYA 4XECX 3NZ9X 4KBNA 1DRBA 3TD8A 1RX6A 3NZBX 4HOEA 1DR1A 3IROA 3QYOA 4KM2A 5HUIA 3SQYX 1RG7A 3QFXA 4HA7A 2W3WA 3UM5A 2OBCA 1RA2A 4EJ1A 1LUDA 4PSYA 2C2TA 3JWKA 5CC9A 1S3VA 4KYAA 3SRQX 5ECXA 2INQA 1M7AA 1DHJA 5U26A 4DFRA 1DRHA 3M08A 4PTJA 1DR3A 2C2SA 5HVEA 2BL9A 1DREA 1KLKA 2D0KA 4KJJA 4PTHA 1M78A 4M7VA 3F0UX 3FQVA 3FS6A 4KNEA 1HFRA 1U71A 3CSEA 3VCOA 4ECKA 3SRWX 2W3AA 3FRFX 3K2HA 3KY8A 1DHFA 4GH8A 3I8AX 3JTWA 4KLXA 4P68A 3NXYA 1DR5A 3SAIA 3JWFA 2O7PA 3JWMA 1IA4A 4Q67A 4XT5A 3FQZA 4X5FA 1LY3A 3F8ZA 3QL0A 5HQZA 1VJ3A 2D5NA 1RX5A 5HT5A 4X5GA 3R33A 3I3RA 2H2QA 3M09A 3QYLA 4X5JA 3SH2A 4G8ZX 3HJ3A 4FGHA 3F0XX 3JSUA 3ROAA 3FQFA 4KL9A 4NX7A 1M79A 3FY8X 3F0QX 5HPBA 1RB3A 3GHWA 3FYVX 3EEJA 3FRBX 4G95A 4CD2A 4P66A 2BLBA 1MVTA 3GI2A 1DYIA 3KJSA 3JW3A 3IRNA 1JUVA 4I1NA 4PSTA 3UM8A 1DRFA 3IRMA 1PD8A 2CIGA 5FDAA 3SRSX 5JG0X 1J3JA 3F0VX 4XRBA 4ELFA 4LAEX 3E0BA 5HT4A 4M2XA 1IA1A 1DR7A 3QLSA 4G3MA 4QJCA 1RX7A 4ELGA 1JOLA 3OAFA 2HXVA 3S9UA 1KMSA 5E8QA 1DRAA 4KJLA 4P3QA 3EX8A 1CZ3A 2BLCA 3ZPCA 4KEBA 3FQ0A 1RA8A 3NXOA 4LAGX 3NU0A 1CD2A 5EAJA 3RG9A 1AO8A 3FRAX 1RX3A 4QHVA 4KFJA 1HFPA 4M6JA 2ANOA 4DDRA 3EIGA 3KFYA 4X5HA 1OHKA 4XT4A 3NZ6X 1YHOA 3DRCA 5HSUA 1DR2A 1IA3A 1RE7A 5DFRA 3SRUX 3TQ9A 1RC4A 4Q0DA 4XT7A 3Q1HA 4I13A 3NXXA 2LF1A 4QLGA 1DG8A 5HI6A 5HSRA 4X5IA 2JYBA 3SRRX 3D84X 4P3RA 1RX9A 4H97A 1JOMA 3K45A 2KGKA 3FQCA 1DISA 1DHIA 3FRDX 5HVBA 3ZPGA 1DYJA 3GHCA 3DAUA 3SA2A 2QK8A 4HOFA 4IXGX 1PD9A 2CD2A 2FZIA 1RX2A 3QL3A 3SA1A 2XW7A 3S3VA 6DFRA 3DATA 4TU5X 4KAKA 4KJKA 3FYWX 4KD7A 3JWCA 1DDRA 4LAHX 3TQAA 2OIPA 1DR6A 1AI9A 4QLEA 5HF0X 1D1GA 1TDRA 3JVXA 2P4GA 4H98A 1ZDRA 2W3BA 1LY4A 1SEJA 1RH3A 3EEMA 5CCCA 1DLRA 1DF7A 3IX9A 2HM9A 3K74A 1DR4A 1DYRA 3QLWA 4DP3A 1AOEA 2W9GA 4OR7A 3IA5A 3TQBA 3SR5X 2W9TA 3S7AA 3QGTA 3QLYA 4LEKX 3OCHA 3RO9A 2B3ZA 4RGCA 2DHFA 2AZNA 3F91A 4PDJA 1KMVA 3DG8A 2W9HA 4ELHA 1PDBA 5HQYA 4XT6A 1RB2A 3DGAA 3CLBA 3NZAX 4ELEA 5ECCA 3FL8A 3QG2A 2W3VA 4FHBA 1RX1A 1DYHA 1J3IA 3EELA 4Q6AA 8DFRA 4ELBA 3INVA 4Q0EA 5U27A 1QZFA 1S3WA 3KJRA 4HOGA 4XE6X 1DG5A 1IA2A 3N0HA 3NTZA 1OHJA 3DL6A 1RD7A 5JA3A 1J3KA 2ANQA 4DPDA 2W3MA 4QJZD 3CL9A 2L28A 4M7UA 3QLXA 3GHVA 4FGGA 3NZCX 4DPHA 4H95A 3DL5A 4PSSA 3JW5A 3F0BX 4XT8A 3F8YA 1MVSA 4IXED 2FZHA 2BLAA 4OSGA 3GYFA 1RX8A 3D80A 1S3UA 1DLSA 1DG7A 2HQPA 3TQ8A 3CD2A 1U70A 4NX6A 3EEKA 3K47A 1BZFA 1RX4A 3DFRA 3FREX 3LG4A 3NZDA 4KM0A 4HA9A 1RA3A 5HF2X 3HBBA 2G6VA 3QLZA 1RF7A 3IA4A 1E26A 1RA9A 1S3YA 3FQOA 4EIGA 2FZJA 3QLRA 3NXRA 4KY4A 3L3RA 3NXTA 1VDRA 4QLFA 4M6KA 1DIUA 1U72A 3NXVA 4M6LA 4QI9A 7DFRA 1HFQA 3FL9A 2W9SA 2GD9A 4IXFX 3NRRA 2ZZAA 4KY8A 4H96A 5DXVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DDS A;  3F0S X;  2DRC A;  1RA1 A;  3UM6 A;  3SGY A;  1BOZ A;  2ITH A;  3FY9 X;  4EIL A;  4EIZ A;  1DAJ A;  3KGY A;  4XEC X;  3NZ9 X;  4KBN A;  1DRB A;  3TD8 A;  1RX6 A;  3NZB X;  4HOE A;  1DR1 A;  3IRO A;  3QYO A;  4KM2 A;  5HUI A;  3SQY X;  1RG7 A;  3QFX A;  4HA7 A;  2W3W A;  3UM5 A;  2OBC A;  1RA2 A;  4EJ1 A;  1LUD A;  4PSY A;  2C2T A;  3JWK A;  5CC9 A;  1S3V A;  4KYA A;  3SRQ X;  5ECX A;  2INQ A;  1M7A A;  1DHJ A;  5U26 A;  4DFR A;  1DRH A;  3M08 A;  4PTJ A;  1DR3 A;  2C2S A;  5HVE A;  2BL9 A;  1DRE A;  1KLK A;  2D0K A;  4KJJ A;  4PTH A;  1M78 A;  4M7V A;  3F0U X;  3FQV A;  3FS6 A;  4KNE A;  1HFR A;  1U71 A;  3CSE A;  3VCO A;  4ECK A;  3SRW X;  2W3A A;  3FRF X;  3K2H A;  3KY8 A;  1DHF A;  4GH8 A;  3I8A X;  3JTW A;  4KLX A;  4P68 A;  3NXY A;  1DR5 A;  3SAI A;  3JWF A;  2O7P A;  3JWM A;  1IA4 A;  4Q67 A;  4XT5 A;  3FQZ A;  4X5F A;  1LY3 A;  3F8Z A;  3QL0 A;  5HQZ A;  1VJ3 A;  2D5N A;  1RX5 A;  5HT5 A;  4X5G A;  3R33 A;  3I3R A;  2H2Q A;  3M09 A;  3QYL A;  4X5J A;  3SH2 A;  4G8Z X;  3HJ3 A;  4FGH A;  3F0X X;  3JSU A;  3ROA A;  3FQF A;  4KL9 A;  4NX7 A;  1M79 A;  3FY8 X;  3F0Q X;  5HPB A;  1RB3 A;  3GHW A;  3FYV X;  3EEJ A;  3FRB X;  4G95 A;  4CD2 A;  4P66 A;  2BLB A;  1MVT A;  3GI2 A;  1DYI A;  3KJS A;  3JW3 A;  3IRN A;  1JUV A;  4I1N A;  4PST A;  3UM8 A;  1DRF A;  3IRM A;  1PD8 A;  2CIG A;  5FDA A;  3SRS X;  5JG0 X;  1J3J A;  3F0V X;  4XRB A;  4ELF A;  4LAE X;  3E0B A;  5HT4 A;  4M2X A;  1IA1 A;  1DR7 A;  3QLS A;  4G3M A;  4QJC A;  1RX7 A;  4ELG A;  1JOL A;  3OAF A;  2HXV A;  3S9U A;  1KMS A;  5E8Q A;  1DRA A;  4KJL A;  4P3Q A;  3EX8 A;  1CZ3 A;  2BLC A;  3ZPC A;  4KEB A;  3FQ0 A;  1RA8 A;  3NXO A;  4LAG X;  3NU0 A;  1CD2 A;  5EAJ A;  3RG9 A;  1AO8 A;  3FRA X;  1RX3 A;  4QHV A;  4KFJ A;  1HFP A;  4M6J A;  2ANO A;  4DDR A;  3EIG A;  3KFY A;  4X5H A;  1OHK A;  4XT4 A;  3NZ6 X;  1YHO A;  3DRC A;  5HSU A;  1DR2 A;  1IA3 A;  1RE7 A;  5DFR A;  3SRU X;  3TQ9 A;  1RC4 A;  4Q0D A;  4XT7 A;  3Q1H A;  4I13 A;  3NXX A;  2LF1 A;  4QLG A;  1DG8 A;  5HI6 A;  5HSR A;  4X5I A;  2JYB A;  3SRR X;  3D84 X;  4P3R A;  1RX9 A;  4H97 A;  1JOM A;  3K45 A;  2KGK A;  3FQC A;  1DIS A;  1DHI A;  3FRD X;  5HVB A;  3ZPG A;  1DYJ A;  3GHC A;  3DAU A;  3SA2 A;  2QK8 A;  4HOF A;  4IXG X;  1PD9 A;  2CD2 A;  2FZI A;  1RX2 A;  3QL3 A;  3SA1 A;  2XW7 A;  3S3V A;  6DFR A;  3DAT A;  4TU5 X;  4KAK A;  4KJK A;  3FYW X;  4KD7 A;  3JWC A;  1DDR A;  4LAH X;  3TQA A;  2OIP A;  1DR6 A;  1AI9 A;  4QLE A;  5HF0 X;  1D1G A;  1TDR A;  3JVX A;  2P4G A;  4H98 A;  1ZDR A;  2W3B A;  1LY4 A;  1SEJ A;  1RH3 A;  3EEM A;  5CCC A;  1DLR A;  1DF7 A;  3IX9 A;  2HM9 A;  3K74 A;  1DR4 A;  1DYR A;  3QLW A;  4DP3 A;  1AOE A;  2W9G A;  4OR7 A;  3IA5 A;  3TQB A;  3SR5 X;  2W9T A;  3S7A A;  3QGT A;  3QLY A;  4LEK X;  3OCH A;  3RO9 A;  2B3Z A;  4RGC A;  2DHF A;  2AZN A;  3F91 A;  4PDJ A;  1KMV A;  3DG8 A;  2W9H A;  4ELH A;  1PDB A;  5HQY A;  4XT6 A;  1RB2 A;  3DGA A;  3CLB A;  3NZA X;  4ELE A;  5ECC A;  3FL8 A;  3QG2 A;  2W3V A;  4FHB A;  1RX1 A;  1DYH A;  1J3I A;  3EEL A;  4Q6A A;  8DFR A;  4ELB A;  3INV A;  4Q0E A;  5U27 A;  1QZF A;  1S3W A;  3KJR A;  4HOG A;  4XE6 X;  1DG5 A;  1IA2 A;  3N0H A;  3NTZ A;  1OHJ A;  3DL6 A;  1RD7 A;  5JA3 A;  1J3K A;  2ANQ A;  4DPD A;  2W3M A;  4QJZ D;  3CL9 A;  2L28 A;  4M7U A;  3QLX A;  3GHV A;  4FGG A;  3NZC X;  4DPH A;  4H95 A;  3DL5 A;  4PSS A;  3JW5 A;  3F0B X;  4XT8 A;  3F8Y A;  1MVS A;  4IXE D;  2FZH A;  2BLA A;  4OSG A;  3GYF A;  1RX8 A;  3D80 A;  1S3U A;  1DLS A;  1DG7 A;  2HQP A;  3TQ8 A;  3CD2 A;  1U70 A;  4NX6 A;  3EEK A;  3K47 A;  1BZF A;  1RX4 A;  3DFR A;  3FRE X;  3LG4 A;  3NZD A;  4KM0 A;  4HA9 A;  1RA3 A;  5HF2 X;  3HBB A;  2G6V A;  3QLZ A;  1RF7 A;  3IA4 A;  1E26 A;  1RA9 A;  1S3Y A;  3FQO A;  4EIG A;  2FZJ A;  3QLR A;  3NXR A;  4KY4 A;  3L3R A;  3NXT A;  1VDR A;  4QLF A;  4M6K A;  1DIU A;  1U72 A;  3NXV A;  4M6L A;  4QI9 A;  7DFR A;  1HFQ A;  3FL9 A;  2W9S A;  2GD9 A;  4IXF X;  3NRR A;  2ZZA A;  4KY8 A;  4H96 A;  5DXV A; 
#chains in the Genus database with same CATH topology
 1DDS A;  3F0S X;  2DRC A;  1RA1 A;  3UM6 A;  3SGY A;  1BOZ A;  2ITH A;  3FY9 X;  4EIL A;  4EIZ A;  1DAJ A;  3KGY A;  4XEC X;  3NZ9 X;  4KBN A;  1DRB A;  3TD8 A;  1RX6 A;  3NZB X;  4HOE A;  1DR1 A;  3IRO A;  3QYO A;  4KM2 A;  5HUI A;  3SQY X;  1RG7 A;  3QFX A;  4HA7 A;  2W3W A;  3UM5 A;  2OBC A;  1RA2 A;  4EJ1 A;  1LUD A;  4PSY A;  2C2T A;  3JWK A;  5CC9 A;  1S3V A;  4KYA A;  3SRQ X;  5ECX A;  2INQ A;  1M7A A;  1DHJ A;  5U26 A;  4DFR A;  1DRH A;  3M08 A;  4PTJ A;  1DR3 A;  2C2S A;  5HVE A;  2BL9 A;  1DRE A;  1KLK A;  2D0K A;  4KJJ A;  4PTH A;  1M78 A;  4M7V A;  3F0U X;  3FQV A;  3FS6 A;  4KNE A;  1HFR A;  1U71 A;  3CSE A;  3VCO A;  4ECK A;  3SRW X;  2W3A A;  3FRF X;  3K2H A;  3KY8 A;  1DHF A;  4GH8 A;  3I8A X;  3JTW A;  4KLX A;  4P68 A;  3NXY A;  1DR5 A;  3SAI A;  3JWF A;  2O7P A;  3JWM A;  1IA4 A;  4Q67 A;  4XT5 A;  3FQZ A;  4X5F A;  1LY3 A;  3F8Z A;  3QL0 A;  5HQZ A;  1VJ3 A;  2D5N A;  1RX5 A;  5HT5 A;  4X5G A;  3R33 A;  3I3R A;  2H2Q A;  3M09 A;  3QYL A;  4X5J A;  3SH2 A;  4G8Z X;  3HJ3 A;  4FGH A;  3F0X X;  3JSU A;  3ROA A;  3FQF A;  4KL9 A;  4NX7 A;  1M79 A;  3FY8 X;  3F0Q X;  5HPB A;  1RB3 A;  3GHW A;  3FYV X;  3EEJ A;  3FRB X;  4G95 A;  4CD2 A;  4P66 A;  2BLB A;  1MVT A;  3GI2 A;  1DYI A;  3KJS A;  3JW3 A;  3IRN A;  1JUV A;  4I1N A;  4PST A;  3UM8 A;  1DRF A;  3IRM A;  1PD8 A;  2CIG A;  5FDA A;  3SRS X;  5JG0 X;  1J3J A;  3F0V X;  4XRB A;  4ELF A;  4LAE X;  3E0B A;  5HT4 A;  4M2X A;  1IA1 A;  1DR7 A;  3QLS A;  4G3M A;  4QJC A;  1RX7 A;  4ELG A;  1JOL A;  3OAF A;  2HXV A;  3S9U A;  1KMS A;  5E8Q A;  1DRA A;  4KJL A;  4P3Q A;  3EX8 A;  1CZ3 A;  2BLC A;  3ZPC A;  4KEB A;  3FQ0 A;  1RA8 A;  3NXO A;  4LAG X;  3NU0 A;  1CD2 A;  5EAJ A;  3RG9 A;  1AO8 A;  3FRA X;  1RX3 A;  4QHV A;  4KFJ A;  1HFP A;  4M6J A;  2ANO A;  4DDR A;  3EIG A;  3KFY A;  4X5H A;  1OHK A;  4XT4 A;  3NZ6 X;  1YHO A;  3DRC A;  5HSU A;  1DR2 A;  1IA3 A;  1RE7 A;  5DFR A;  3SRU X;  3TQ9 A;  1RC4 A;  4Q0D A;  4XT7 A;  3Q1H A;  4I13 A;  3NXX A;  2LF1 A;  4QLG A;  1DG8 A;  5HI6 A;  5HSR A;  4X5I A;  2JYB A;  3SRR X;  3D84 X;  4P3R A;  1RX9 A;  4H97 A;  1JOM A;  3K45 A;  2KGK A;  3FQC A;  1DIS A;  1DHI A;  3FRD X;  5HVB A;  3ZPG A;  1DYJ A;  3GHC A;  3DAU A;  3SA2 A;  2QK8 A;  4HOF A;  4IXG X;  1PD9 A;  2CD2 A;  2FZI A;  1RX2 A;  3QL3 A;  3SA1 A;  2XW7 A;  3S3V A;  6DFR A;  3DAT A;  4TU5 X;  4KAK A;  4KJK A;  3FYW X;  4KD7 A;  3JWC A;  1DDR A;  4LAH X;  3TQA A;  2OIP A;  1DR6 A;  1AI9 A;  4QLE A;  5HF0 X;  1D1G A;  1TDR A;  3JVX A;  2P4G A;  4H98 A;  1ZDR A;  2W3B A;  1LY4 A;  1SEJ A;  1RH3 A;  3EEM A;  5CCC A;  1DLR A;  1DF7 A;  3IX9 A;  2HM9 A;  3K74 A;  1DR4 A;  1DYR A;  3QLW A;  4DP3 A;  1AOE A;  2W9G A;  4OR7 A;  3IA5 A;  3TQB A;  3SR5 X;  2W9T A;  3S7A A;  3QGT A;  3QLY A;  4LEK X;  3OCH A;  3RO9 A;  2B3Z A;  4RGC A;  2DHF A;  2AZN A;  3F91 A;  4PDJ A;  1KMV A;  3DG8 A;  2W9H A;  4ELH A;  1PDB A;  5HQY A;  4XT6 A;  1RB2 A;  3DGA A;  3CLB A;  3NZA X;  4ELE A;  5ECC A;  3FL8 A;  3QG2 A;  2W3V A;  4FHB A;  1RX1 A;  1DYH A;  1J3I A;  3EEL A;  4Q6A A;  8DFR A;  4ELB A;  3INV A;  4Q0E A;  5U27 A;  1QZF A;  1S3W A;  3KJR A;  4HOG A;  4XE6 X;  1DG5 A;  1IA2 A;  3N0H A;  3NTZ A;  1OHJ A;  3DL6 A;  1RD7 A;  5JA3 A;  1J3K A;  2ANQ A;  4DPD A;  2W3M A;  4QJZ D;  3CL9 A;  2L28 A;  4M7U A;  3QLX A;  3GHV A;  4FGG A;  3NZC X;  4DPH A;  4H95 A;  3DL5 A;  4PSS A;  3JW5 A;  3F0B X;  4XT8 A;  3F8Y A;  1MVS A;  4IXE D;  2FZH A;  2BLA A;  4OSG A;  3GYF A;  1RX8 A;  3D80 A;  1S3U A;  1DLS A;  1DG7 A;  2HQP A;  3TQ8 A;  3CD2 A;  1U70 A;  4NX6 A;  3EEK A;  3K47 A;  1BZF A;  1RX4 A;  3DFR A;  3FRE X;  3LG4 A;  3NZD A;  4KM0 A;  4HA9 A;  1RA3 A;  5HF2 X;  3HBB A;  2G6V A;  3QLZ A;  1RF7 A;  3IA4 A;  1E26 A;  1RA9 A;  1S3Y A;  3FQO A;  4EIG A;  2FZJ A;  3QLR A;  3NXR A;  4KY4 A;  3L3R A;  3NXT A;  1VDR A;  4QLF A;  4M6K A;  1DIU A;  1U72 A;  3NXV A;  4M6L A;  4QI9 A;  7DFR A;  1HFQ A;  3FL9 A;  2W9S A;  2GD9 A;  4IXF X;  3NRR A;  2ZZA A;  4KY8 A;  4H96 A;  5DXV A; 
#chains in the Genus database with same CATH homology
 1DDS A;  3F0S X;  2DRC A;  1RA1 A;  3UM6 A;  3SGY A;  1BOZ A;  2ITH A;  3FY9 X;  4EIL A;  4EIZ A;  1DAJ A;  3KGY A;  4XEC X;  3NZ9 X;  4KBN A;  1DRB A;  3TD8 A;  1RX6 A;  3NZB X;  4HOE A;  1DR1 A;  3IRO A;  3QYO A;  4KM2 A;  5HUI A;  3SQY X;  1RG7 A;  3QFX A;  4HA7 A;  2W3W A;  3UM5 A;  2OBC A;  1RA2 A;  4EJ1 A;  1LUD A;  4PSY A;  2C2T A;  3JWK A;  5CC9 A;  1S3V A;  4KYA A;  3SRQ X;  5ECX A;  2INQ A;  1M7A A;  1DHJ A;  5U26 A;  4DFR A;  1DRH A;  3M08 A;  4PTJ A;  1DR3 A;  2C2S A;  5HVE A;  2BL9 A;  1DRE A;  1KLK A;  2D0K A;  4KJJ A;  4PTH A;  1M78 A;  4M7V A;  3F0U X;  3FQV A;  3FS6 A;  4KNE A;  1HFR A;  1U71 A;  3CSE A;  3VCO A;  4ECK A;  3SRW X;  2W3A A;  3FRF X;  3K2H A;  3KY8 A;  1DHF A;  4GH8 A;  3I8A X;  3JTW A;  4KLX A;  4P68 A;  3NXY A;  1DR5 A;  3SAI A;  3JWF A;  2O7P A;  3JWM A;  1IA4 A;  4Q67 A;  4XT5 A;  3FQZ A;  4X5F A;  1LY3 A;  3F8Z A;  3QL0 A;  5HQZ A;  1VJ3 A;  2D5N A;  1RX5 A;  5HT5 A;  4X5G A;  3R33 A;  3I3R A;  2H2Q A;  3M09 A;  3QYL A;  4X5J A;  3SH2 A;  4G8Z X;  3HJ3 A;  4FGH A;  3F0X X;  3JSU A;  3ROA A;  3FQF A;  4KL9 A;  4NX7 A;  1M79 A;  3FY8 X;  3F0Q X;  5HPB A;  1RB3 A;  3GHW A;  3FYV X;  3EEJ A;  3FRB X;  4G95 A;  4CD2 A;  4P66 A;  2BLB A;  1MVT A;  3GI2 A;  1DYI A;  3KJS A;  3JW3 A;  3IRN A;  1JUV A;  4I1N A;  4PST A;  3UM8 A;  1DRF A;  3IRM A;  1PD8 A;  2CIG A;  5FDA A;  3SRS X;  5JG0 X;  1J3J A;  3F0V X;  4XRB A;  4ELF A;  4LAE X;  3E0B A;  5HT4 A;  4M2X A;  1IA1 A;  1DR7 A;  3QLS A;  4G3M A;  4QJC A;  1RX7 A;  4ELG A;  1JOL A;  3OAF A;  2HXV A;  3S9U A;  1KMS A;  5E8Q A;  1DRA A;  4KJL A;  4P3Q A;  3EX8 A;  1CZ3 A;  2BLC A;  3ZPC A;  4KEB A;  3FQ0 A;  1RA8 A;  3NXO A;  4LAG X;  3NU0 A;  1CD2 A;  5EAJ A;  3RG9 A;  1AO8 A;  3FRA X;  1RX3 A;  4QHV A;  4KFJ A;  1HFP A;  4M6J A;  2ANO A;  4DDR A;  3EIG A;  3KFY A;  4X5H A;  1OHK A;  4XT4 A;  3NZ6 X;  1YHO A;  3DRC A;  5HSU A;  1DR2 A;  1IA3 A;  1RE7 A;  5DFR A;  3SRU X;  3TQ9 A;  1RC4 A;  4Q0D A;  4XT7 A;  3Q1H A;  4I13 A;  3NXX A;  2LF1 A;  4QLG A;  1DG8 A;  5HI6 A;  5HSR A;  4X5I A;  2JYB A;  3SRR X;  3D84 X;  4P3R A;  1RX9 A;  4H97 A;  1JOM A;  3K45 A;  2KGK A;  3FQC A;  1DIS A;  1DHI A;  3FRD X;  5HVB A;  3ZPG A;  1DYJ A;  3GHC A;  3DAU A;  3SA2 A;  2QK8 A;  4HOF A;  4IXG X;  1PD9 A;  2CD2 A;  2FZI A;  1RX2 A;  3QL3 A;  3SA1 A;  2XW7 A;  3S3V A;  6DFR A;  3DAT A;  4TU5 X;  4KAK A;  4KJK A;  3FYW X;  4KD7 A;  3JWC A;  1DDR A;  4LAH X;  3TQA A;  2OIP A;  1DR6 A;  1AI9 A;  4QLE A;  5HF0 X;  1D1G A;  1TDR A;  3JVX A;  2P4G A;  4H98 A;  1ZDR A;  2W3B A;  1LY4 A;  1SEJ A;  1RH3 A;  3EEM A;  5CCC A;  1DLR A;  1DF7 A;  3IX9 A;  2HM9 A;  3K74 A;  1DR4 A;  1DYR A;  3QLW A;  4DP3 A;  1AOE A;  2W9G A;  4OR7 A;  3IA5 A;  3TQB A;  3SR5 X;  2W9T A;  3S7A A;  3QGT A;  3QLY A;  4LEK X;  3OCH A;  3RO9 A;  2B3Z A;  4RGC A;  2DHF A;  2AZN A;  3F91 A;  4PDJ A;  1KMV A;  3DG8 A;  2W9H A;  4ELH A;  1PDB A;  5HQY A;  4XT6 A;  1RB2 A;  3DGA A;  3CLB A;  3NZA X;  4ELE A;  5ECC A;  3FL8 A;  3QG2 A;  2W3V A;  4FHB A;  1RX1 A;  1DYH A;  1J3I A;  3EEL A;  4Q6A A;  8DFR A;  4ELB A;  3INV A;  4Q0E A;  5U27 A;  1QZF A;  1S3W A;  3KJR A;  4HOG A;  4XE6 X;  1DG5 A;  1IA2 A;  3N0H A;  3NTZ A;  1OHJ A;  3DL6 A;  1RD7 A;  5JA3 A;  1J3K A;  2ANQ A;  4DPD A;  2W3M A;  4QJZ D;  3CL9 A;  2L28 A;  4M7U A;  3QLX A;  3GHV A;  4FGG A;  3NZC X;  4DPH A;  4H95 A;  3DL5 A;  4PSS A;  3JW5 A;  3F0B X;  4XT8 A;  3F8Y A;  1MVS A;  4IXE D;  2FZH A;  2BLA A;  4OSG A;  3GYF A;  1RX8 A;  3D80 A;  1S3U A;  1DLS A;  1DG7 A;  2HQP A;  3TQ8 A;  3CD2 A;  1U70 A;  4NX6 A;  3EEK A;  3K47 A;  1BZF A;  1RX4 A;  3DFR A;  3FRE X;  3LG4 A;  3NZD A;  4KM0 A;  4HA9 A;  1RA3 A;  5HF2 X;  3HBB A;  2G6V A;  3QLZ A;  1RF7 A;  3IA4 A;  1E26 A;  1RA9 A;  1S3Y A;  3FQO A;  4EIG A;  2FZJ A;  3QLR A;  3NXR A;  4KY4 A;  3L3R A;  3NXT A;  1VDR A;  4QLF A;  4M6K A;  1DIU A;  1U72 A;  3NXV A;  4M6L A;  4QI9 A;  7DFR A;  1HFQ A;  3FL9 A;  2W9S A;  2GD9 A;  4IXF X;  3NRR A;  2ZZA A;  4KY8 A;  4H96 A;  5DXV A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...