3F8YA

Correlations of human dihydrofolate reductase with structural data for human active site mutant enzyme complexes
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFKRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 56
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2008-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3f8yA00
4DDRA 1AI9A 4M7UA 1DHIA 2B3ZA 1S3YA 3NZCX 4Q6AA 1U72A 2W3VA 5HPBA 4X5IA 3F8YA 3FYWX 1ZDRA 4M7VA 2CIGA 1OHJA 1DG5A 1DHFA 2W3MA 3FYVX 3NTZA 3S3VA 4P68A 1DISA 3F0SX 3SRRX 1DG8A 2DRCA 3KY8A 1DYIA 3RO9A 3K45A 3SA2A 2BLBA 1JOMA 3LG4A 3JTWA 3NRRA 1RX3A 3VCOA 3DAUA 2FZHA 1LUDA 3FREX 3QYLA 4I13A 4QI9A 4I1NA 1RX5A 4FGGA 1RB3A 4P66A 3TD8A 1DDSA 1RX4A 3F0BX 4QLFA 3JWCA 3R33A 4HOFA 5DFRA 1DLSA 4G95A 2ITHA 4H95A 5JA3A 4KD7A 1M7AA 1QZFA 4QLGA 1DYJA 5U27A 1IA3A 2BL9A 3EX8A 3GYFA 1J3KA 1DR7A 2C2SA 3SQYX 3IROA 3DATA 1RX1A 3JVXA 1RX9A 3FL9A 3M09A 1RC4A 3QFXA 1DLRA 3JW3A 5HT4A 1CD2A 3GHWA 4DFRA 4OR7A 1DIUA 2W3BA 3TQ9A 2GD9A 2QK8A 4G8ZX 4QJCA 4M6KA 4KY8A 4M2XA 4NX6A 1BZFA 5ECCA 4KBNA 3QLYA 4IXGX 3IA4A 1KMVA 3S7AA 3S9UA 3DG8A 3ROAA 1J3JA 2BLAA 5E8QA 3FQVA 3NZBX 3QLSA 1E26A 8DFRA 1CZ3A 5HI6A 1MVSA 2KGKA 1RF7A 3INVA 2CD2A 1RA8A 3FRAX 5HVEA 2ANOA 4X5GA 3RG9A 3FRBX 4PTHA 3JWFA 1KMSA 4XECX 1RX8A 4EIZA 1PD9A 1S3UA 3F0VX 3EEMA 1DR5A 1LY4A 4X5FA 5DXVA 4H98A 1RH3A 3NZAX 1S3WA 5HT5A 5FDAA 4EILA 1DAJA 1IA2A 2L28A 3QYOA 4IXFX 5CCCA 2H2QA 4KJLA 1RX2A 2C2TA 1DYHA 3K2HA 1DR1A 3FQ0A 4HA9A 3EELA 1JOLA 1PD8A 4H97A 3JW5A 3K74A 2AZNA 3UM8A 2W9GA 3JWKA 5JG0X 3DRCA 4CD2A 3NXXA 4X5JA 1IA4A 3NZ9X 3D84X 5ECXA 1RE7A 6DFRA 2ANQA 4KAKA 3GHVA 3NXTA 3IRNA 3QLRA 1IA1A 4ELBA 1SEJA 3FRDX 4NX7A 5HF2X 4LEKX 2HQPA 4XT7A 3KJRA 1RA3A 1DDRA 4Q0DA 3QL0A 2W9SA 1YHOA 4FGHA 4LAEX 4QLEA 3K47A 3FQZA 1DREA 3FY9X 3NZ6X 4G3MA 1DRAA 7DFRA 4EIGA 3IA5A 3SA1A 4ELGA 3KFYA 4DPDA 4KM0A 3UM6A 4FHBA 4DP3A 3F0QX 1AOEA 3CLBA 3HBBA 3HJ3A 3FQCA 2W9TA 1DR3A 3SH2A 3SRUX 1J3IA 5EAJA 3FL8A 3N0HA 2W3WA 2O7PA 4LAHX 2LF1A 3SAIA 3F0XX 5HSRA 5HVBA 1DR2A 2ZZAA 3FS6A 4Q0EA 4M6JA 4KY4A 3FQOA 3Q1HA 3TQ8A 1DRFA 2W3AA 3D80A 4ELHA 1MVTA 1RD7A 4XT5A 3CD2A 4PTJA 1DF7A 3DFRA 3DGAA 4M6LA 4ELEA 3TQBA 1U71A 2BLCA 3QLXA 2JYBA 1RX7A 1VDRA 2D0KA 3KGYA 4PSYA 4XT6A 4P3RA 4DPHA 3EIGA 3OCHA 1DR6A 3UM5A 1RA2A 4KYAA 1JUVA 3DL6A 3QGTA 4PSSA 1DHJA 1BOZA 4QHVA 1RG7A 3F8ZA 4IXED 4X5HA 1TDRA 1RA9A 3JSUA 3NXOA 3ZPGA 4KNEA 3SRSX 3IX9A 4KFJA 5HF0X 1U70A 1RB2A 1OHKA 2HXVA 3FQFA 2D5NA 2INQA 3IRMA 3FRFX 2W9HA 3OAFA 1DG7A 4RGCA 3NXYA 4XT4A 5U26A 3I8AX 4QJZD 3NXRA 3QL3A 3QLZA 1KLKA 4KLXA 4OSGA 3SR5X 3I3RA 2OBCA 3F91A 4HA7A 1LY3A 1RA1A 1DRBA 4H96A 3NZDA 3E0BA 2XW7A 1HFQA 3CL9A 3L3RA 4LAGX 1DRHA 4P3QA 3TQAA 1S3VA 4EJ1A 3F0UX 3KJSA 3FY8X 4ELFA 4TU5X 3GHCA 4Q67A 4KM2A 3GI2A 2G6VA 4HOEA 4PDJA 1VJ3A 3SRQX 3M08A 3SGYA 4KL9A 2P4GA 1M78A 2FZJA 2HM9A 3SRWX 1D1GA 4KJJA 5HQZA 4HOGA 5HSUA 3QLWA 3ZPCA 4XT8A 3NU0A 3EEJA 3NXVA 4KJKA 3CSEA 1DR4A 3JWMA 5CC9A 1AO8A 2FZIA 4PSTA 1PDBA 4GH8A 4XE6X 1HFRA 1RX6A 3EEKA 4ECKA 3QG2A 5HQYA 3DL5A 2OIPA 1M79A 1HFPA 1DYRA 4XRBA 2DHFA 4KEBA 5HUIA
chains in the Genus database with same CATH superfamily
4DDRA 1AI9A 4M7UA 1DHIA 2B3ZA 1S3YA 3NZCX 4Q6AA 1U72A 2W3VA 5HPBA 4X5IA 3F8YA 3FYWX 1ZDRA 4M7VA 2CIGA 1OHJA 1DG5A 1DHFA 2W3MA 3FYVX 3NTZA 3S3VA 4P68A 1DISA 3F0SX 3SRRX 1DG8A 2DRCA 3KY8A 1DYIA 3RO9A 3K45A 3SA2A 2BLBA 1JOMA 3LG4A 3JTWA 3NRRA 1RX3A 3VCOA 3DAUA 2FZHA 1LUDA 3FREX 3QYLA 4I13A 4QI9A 4I1NA 1RX5A 4FGGA 1RB3A 4P66A 3TD8A 1DDSA 1RX4A 3F0BX 4QLFA 3JWCA 3R33A 4HOFA 5DFRA 1DLSA 4G95A 2ITHA 4H95A 5JA3A 4KD7A 1M7AA 1QZFA 4QLGA 1DYJA 5U27A 1IA3A 2BL9A 3EX8A 3GYFA 1J3KA 1DR7A 2C2SA 3SQYX 3IROA 3DATA 1RX1A 3JVXA 1RX9A 3FL9A 3M09A 1RC4A 3QFXA 1DLRA 3JW3A 5HT4A 1CD2A 3GHWA 4DFRA 4OR7A 1DIUA 2W3BA 3TQ9A 2GD9A 2QK8A 4G8ZX 4QJCA 4M6KA 4KY8A 4M2XA 4NX6A 1BZFA 5ECCA 4KBNA 3QLYA 4IXGX 3IA4A 1KMVA 3S7AA 3S9UA 3DG8A 3ROAA 1J3JA 2BLAA 5E8QA 3FQVA 3NZBX 3QLSA 1E26A 8DFRA 1CZ3A 5HI6A 1MVSA 2KGKA 1RF7A 3INVA 2CD2A 1RA8A 3FRAX 5HVEA 2ANOA 4X5GA 3RG9A 3FRBX 4PTHA 3JWFA 1KMSA 4XECX 1RX8A 4EIZA 1PD9A 1S3UA 3F0VX 3EEMA 1DR5A 1LY4A 4X5FA 5DXVA 4H98A 1RH3A 3NZAX 1S3WA 5HT5A 5FDAA 4EILA 1DAJA 1IA2A 2L28A 3QYOA 4IXFX 5CCCA 2H2QA 4KJLA 1RX2A 2C2TA 1DYHA 3K2HA 1DR1A 3FQ0A 4HA9A 3EELA 1JOLA 1PD8A 4H97A 3JW5A 3K74A 2AZNA 3UM8A 2W9GA 3JWKA 5JG0X 3DRCA 4CD2A 3NXXA 4X5JA 1IA4A 3NZ9X 3D84X 5ECXA 1RE7A 6DFRA 2ANQA 4KAKA 3GHVA 3NXTA 3IRNA 3QLRA 1IA1A 4ELBA 1SEJA 3FRDX 4NX7A 5HF2X 4LEKX 2HQPA 4XT7A 3KJRA 1RA3A 1DDRA 4Q0DA 3QL0A 2W9SA 1YHOA 4FGHA 4LAEX 4QLEA 3K47A 3FQZA 1DREA 3FY9X 3NZ6X 4G3MA 1DRAA 7DFRA 4EIGA 3IA5A 3SA1A 4ELGA 3KFYA 4DPDA 4KM0A 3UM6A 4FHBA 4DP3A 3F0QX 1AOEA 3CLBA 3HBBA 3HJ3A 3FQCA 2W9TA 1DR3A 3SH2A 3SRUX 1J3IA 5EAJA 3FL8A 3N0HA 2W3WA 2O7PA 4LAHX 2LF1A 3SAIA 3F0XX 5HSRA 5HVBA 1DR2A 2ZZAA 3FS6A 4Q0EA 4M6JA 4KY4A 3FQOA 3Q1HA 3TQ8A 1DRFA 2W3AA 3D80A 4ELHA 1MVTA 1RD7A 4XT5A 3CD2A 4PTJA 1DF7A 3DFRA 3DGAA 4M6LA 4ELEA 3TQBA 1U71A 2BLCA 3QLXA 2JYBA 1RX7A 1VDRA 2D0KA 3KGYA 4PSYA 4XT6A 4P3RA 4DPHA 3EIGA 3OCHA 1DR6A 3UM5A 1RA2A 4KYAA 1JUVA 3DL6A 3QGTA 4PSSA 1DHJA 1BOZA 4QHVA 1RG7A 3F8ZA 4IXED 4X5HA 1TDRA 1RA9A 3JSUA 3NXOA 3ZPGA 4KNEA 3SRSX 3IX9A 4KFJA 5HF0X 1U70A 1RB2A 1OHKA 2HXVA 3FQFA 2D5NA 2INQA 3IRMA 3FRFX 2W9HA 3OAFA 1DG7A 4RGCA 3NXYA 4XT4A 5U26A 3I8AX 4QJZD 3NXRA 3QL3A 3QLZA 1KLKA 4KLXA 4OSGA 3SR5X 3I3RA 2OBCA 3F91A 4HA7A 1LY3A 1RA1A 1DRBA 4H96A 3NZDA 3E0BA 2XW7A 1HFQA 3CL9A 3L3RA 4LAGX 1DRHA 4P3QA 3TQAA 1S3VA 4EJ1A 3F0UX 3KJSA 3FY8X 4ELFA 4TU5X 3GHCA 4Q67A 4KM2A 3GI2A 2G6VA 4HOEA 4PDJA 1VJ3A 3SRQX 3M08A 3SGYA 4KL9A 2P4GA 1M78A 2FZJA 2HM9A 3SRWX 1D1GA 4KJJA 5HQZA 4HOGA 5HSUA 3QLWA 3ZPCA 4XT8A 3NU0A 3EEJA 3NXVA 4KJKA 3CSEA 1DR4A 3JWMA 5CC9A 1AO8A 2FZIA 4PSTA 1PDBA 4GH8A 4XE6X 1HFRA 1RX6A 3EEKA 4ECKA 3QG2A 5HQYA 3DL5A 2OIPA 1M79A 1HFPA 1DYRA 4XRBA 2DHFA 4KEBA 5HUIA
chains in the Genus database with same CATH topology
4DDRA 1AI9A 4M7UA 1DHIA 2B3ZA 1S3YA 3NZCX 4Q6AA 1U72A 2W3VA 5HPBA 4X5IA 3F8YA 3FYWX 1ZDRA 4M7VA 2CIGA 1OHJA 1DG5A 1DHFA 2W3MA 3FYVX 3NTZA 3S3VA 4P68A 1DISA 3F0SX 3SRRX 1DG8A 2DRCA 3KY8A 1DYIA 3RO9A 3K45A 3SA2A 2BLBA 1JOMA 3LG4A 3JTWA 3NRRA 1RX3A 3VCOA 3DAUA 2FZHA 1LUDA 3FREX 3QYLA 4I13A 4QI9A 4I1NA 1RX5A 4FGGA 1RB3A 4P66A 3TD8A 1DDSA 1RX4A 3F0BX 4QLFA 3JWCA 3R33A 4HOFA 5DFRA 1DLSA 4G95A 2ITHA 4H95A 5JA3A 4KD7A 1M7AA 1QZFA 4QLGA 1DYJA 5U27A 1IA3A 2BL9A 3EX8A 3GYFA 1J3KA 1DR7A 2C2SA 3SQYX 3IROA 3DATA 1RX1A 3JVXA 1RX9A 3FL9A 3M09A 1RC4A 3QFXA 1DLRA 3JW3A 5HT4A 1CD2A 3GHWA 4DFRA 4OR7A 1DIUA 2W3BA 3TQ9A 2GD9A 2QK8A 4G8ZX 4QJCA 4M6KA 4KY8A 4M2XA 4NX6A 1BZFA 5ECCA 4KBNA 3QLYA 4IXGX 3IA4A 1KMVA 3S7AA 3S9UA 3DG8A 3ROAA 1J3JA 2BLAA 5E8QA 3FQVA 3NZBX 3QLSA 1E26A 8DFRA 1CZ3A 5HI6A 1MVSA 2KGKA 1RF7A 3INVA 2CD2A 1RA8A 3FRAX 5HVEA 2ANOA 4X5GA 3RG9A 3FRBX 4PTHA 3JWFA 1KMSA 4XECX 1RX8A 4EIZA 1PD9A 1S3UA 3F0VX 3EEMA 1DR5A 1LY4A 4X5FA 5DXVA 4H98A 1RH3A 3NZAX 1S3WA 5HT5A 5FDAA 4EILA 1DAJA 1IA2A 2L28A 3QYOA 4IXFX 5CCCA 2H2QA 4KJLA 1RX2A 2C2TA 1DYHA 3K2HA 1DR1A 3FQ0A 4HA9A 3EELA 1JOLA 1PD8A 4H97A 3JW5A 3K74A 2AZNA 3UM8A 2W9GA 3JWKA 5JG0X 3DRCA 4CD2A 3NXXA 4X5JA 1IA4A 3NZ9X 3D84X 5ECXA 1RE7A 6DFRA 2ANQA 4KAKA 3GHVA 3NXTA 3IRNA 3QLRA 1IA1A 4ELBA 1SEJA 3FRDX 4NX7A 5HF2X 4LEKX 2HQPA 4XT7A 3KJRA 1RA3A 1DDRA 4Q0DA 3QL0A 2W9SA 1YHOA 4FGHA 4LAEX 4QLEA 3K47A 3FQZA 1DREA 3FY9X 3NZ6X 4G3MA 1DRAA 7DFRA 4EIGA 3IA5A 3SA1A 4ELGA 3KFYA 4DPDA 4KM0A 3UM6A 4FHBA 4DP3A 3F0QX 1AOEA 3CLBA 3HBBA 3HJ3A 3FQCA 2W9TA 1DR3A 3SH2A 3SRUX 1J3IA 5EAJA 3FL8A 3N0HA 2W3WA 2O7PA 4LAHX 2LF1A 3SAIA 3F0XX 5HSRA 5HVBA 1DR2A 2ZZAA 3FS6A 4Q0EA 4M6JA 4KY4A 3FQOA 3Q1HA 3TQ8A 1DRFA 2W3AA 3D80A 4ELHA 1MVTA 1RD7A 4XT5A 3CD2A 4PTJA 1DF7A 3DFRA 3DGAA 4M6LA 4ELEA 3TQBA 1U71A 2BLCA 3QLXA 2JYBA 1RX7A 1VDRA 2D0KA 3KGYA 4PSYA 4XT6A 4P3RA 4DPHA 3EIGA 3OCHA 1DR6A 3UM5A 1RA2A 4KYAA 1JUVA 3DL6A 3QGTA 4PSSA 1DHJA 1BOZA 4QHVA 1RG7A 3F8ZA 4IXED 4X5HA 1TDRA 1RA9A 3JSUA 3NXOA 3ZPGA 4KNEA 3SRSX 3IX9A 4KFJA 5HF0X 1U70A 1RB2A 1OHKA 2HXVA 3FQFA 2D5NA 2INQA 3IRMA 3FRFX 2W9HA 3OAFA 1DG7A 4RGCA 3NXYA 4XT4A 5U26A 3I8AX 4QJZD 3NXRA 3QL3A 3QLZA 1KLKA 4KLXA 4OSGA 3SR5X 3I3RA 2OBCA 3F91A 4HA7A 1LY3A 1RA1A 1DRBA 4H96A 3NZDA 3E0BA 2XW7A 1HFQA 3CL9A 3L3RA 4LAGX 1DRHA 4P3QA 3TQAA 1S3VA 4EJ1A 3F0UX 3KJSA 3FY8X 4ELFA 4TU5X 3GHCA 4Q67A 4KM2A 3GI2A 2G6VA 4HOEA 4PDJA 1VJ3A 3SRQX 3M08A 3SGYA 4KL9A 2P4GA 1M78A 2FZJA 2HM9A 3SRWX 1D1GA 4KJJA 5HQZA 4HOGA 5HSUA 3QLWA 3ZPCA 4XT8A 3NU0A 3EEJA 3NXVA 4KJKA 3CSEA 1DR4A 3JWMA 5CC9A 1AO8A 2FZIA 4PSTA 1PDBA 4GH8A 4XE6X 1HFRA 1RX6A 3EEKA 4ECKA 3QG2A 5HQYA 3DL5A 2OIPA 1M79A 1HFPA 1DYRA 4XRBA 2DHFA 4KEBA 5HUIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DDR A;  1AI9 A;  4M7U A;  1DHI A;  2B3Z A;  1S3Y A;  3NZC X;  4Q6A A;  1U72 A;  2W3V A;  5HPB A;  4X5I A;  3F8Y A;  3FYW X;  1ZDR A;  4M7V A;  2CIG A;  1OHJ A;  1DG5 A;  1DHF A;  2W3M A;  3FYV X;  3NTZ A;  3S3V A;  4P68 A;  1DIS A;  3F0S X;  3SRR X;  1DG8 A;  2DRC A;  3KY8 A;  1DYI A;  3RO9 A;  3K45 A;  3SA2 A;  2BLB A;  1JOM A;  3LG4 A;  3JTW A;  3NRR A;  1RX3 A;  3VCO A;  3DAU A;  2FZH A;  1LUD A;  3FRE X;  3QYL A;  4I13 A;  4QI9 A;  4I1N A;  1RX5 A;  4FGG A;  1RB3 A;  4P66 A;  3TD8 A;  1DDS A;  1RX4 A;  3F0B X;  4QLF A;  3JWC A;  3R33 A;  4HOF A;  5DFR A;  1DLS A;  4G95 A;  2ITH A;  4H95 A;  5JA3 A;  4KD7 A;  1M7A A;  1QZF A;  4QLG A;  1DYJ A;  5U27 A;  1IA3 A;  2BL9 A;  3EX8 A;  3GYF A;  1J3K A;  1DR7 A;  2C2S A;  3SQY X;  3IRO A;  3DAT A;  1RX1 A;  3JVX A;  1RX9 A;  3FL9 A;  3M09 A;  1RC4 A;  3QFX A;  1DLR A;  3JW3 A;  5HT4 A;  1CD2 A;  3GHW A;  4DFR A;  4OR7 A;  1DIU A;  2W3B A;  3TQ9 A;  2GD9 A;  2QK8 A;  4G8Z X;  4QJC A;  4M6K A;  4KY8 A;  4M2X A;  4NX6 A;  1BZF A;  5ECC A;  4KBN A;  3QLY A;  4IXG X;  3IA4 A;  1KMV A;  3S7A A;  3S9U A;  3DG8 A;  3ROA A;  1J3J A;  2BLA A;  5E8Q A;  3FQV A;  3NZB X;  3QLS A;  1E26 A;  8DFR A;  1CZ3 A;  5HI6 A;  1MVS A;  2KGK A;  1RF7 A;  3INV A;  2CD2 A;  1RA8 A;  3FRA X;  5HVE A;  2ANO A;  4X5G A;  3RG9 A;  3FRB X;  4PTH A;  3JWF A;  1KMS A;  4XEC X;  1RX8 A;  4EIZ A;  1PD9 A;  1S3U A;  3F0V X;  3EEM A;  1DR5 A;  1LY4 A;  4X5F A;  5DXV A;  4H98 A;  1RH3 A;  3NZA X;  1S3W A;  5HT5 A;  5FDA A;  4EIL A;  1DAJ A;  1IA2 A;  2L28 A;  3QYO A;  4IXF X;  5CCC A;  2H2Q A;  4KJL A;  1RX2 A;  2C2T A;  1DYH A;  3K2H A;  1DR1 A;  3FQ0 A;  4HA9 A;  3EEL A;  1JOL A;  1PD8 A;  4H97 A;  3JW5 A;  3K74 A;  2AZN A;  3UM8 A;  2W9G A;  3JWK A;  5JG0 X;  3DRC A;  4CD2 A;  3NXX A;  4X5J A;  1IA4 A;  3NZ9 X;  3D84 X;  5ECX A;  1RE7 A;  6DFR A;  2ANQ A;  4KAK A;  3GHV A;  3NXT A;  3IRN A;  3QLR A;  1IA1 A;  4ELB A;  1SEJ A;  3FRD X;  4NX7 A;  5HF2 X;  4LEK X;  2HQP A;  4XT7 A;  3KJR A;  1RA3 A;  1DDR A;  4Q0D A;  3QL0 A;  2W9S A;  1YHO A;  4FGH A;  4LAE X;  4QLE A;  3K47 A;  3FQZ A;  1DRE A;  3FY9 X;  3NZ6 X;  4G3M A;  1DRA A;  7DFR A;  4EIG A;  3IA5 A;  3SA1 A;  4ELG A;  3KFY A;  4DPD A;  4KM0 A;  3UM6 A;  4FHB A;  4DP3 A;  3F0Q X;  1AOE A;  3CLB A;  3HBB A;  3HJ3 A;  3FQC A;  2W9T A;  1DR3 A;  3SH2 A;  3SRU X;  1J3I A;  5EAJ A;  3FL8 A;  3N0H A;  2W3W A;  2O7P A;  4LAH X;  2LF1 A;  3SAI A;  3F0X X;  5HSR A;  5HVB A;  1DR2 A;  2ZZA A;  3FS6 A;  4Q0E A;  4M6J A;  4KY4 A;  3FQO A;  3Q1H A;  3TQ8 A;  1DRF A;  2W3A A;  3D80 A;  4ELH A;  1MVT A;  1RD7 A;  4XT5 A;  3CD2 A;  4PTJ A;  1DF7 A;  3DFR A;  3DGA A;  4M6L A;  4ELE A;  3TQB A;  1U71 A;  2BLC A;  3QLX A;  2JYB A;  1RX7 A;  1VDR A;  2D0K A;  3KGY A;  4PSY A;  4XT6 A;  4P3R A;  4DPH A;  3EIG A;  3OCH A;  1DR6 A;  3UM5 A;  1RA2 A;  4KYA A;  1JUV A;  3DL6 A;  3QGT A;  4PSS A;  1DHJ A;  1BOZ A;  4QHV A;  1RG7 A;  3F8Z A;  4IXE D;  4X5H A;  1TDR A;  1RA9 A;  3JSU A;  3NXO A;  3ZPG A;  4KNE A;  3SRS X;  3IX9 A;  4KFJ A;  5HF0 X;  1U70 A;  1RB2 A;  1OHK A;  2HXV A;  3FQF A;  2D5N A;  2INQ A;  3IRM A;  3FRF X;  2W9H A;  3OAF A;  1DG7 A;  4RGC A;  3NXY A;  4XT4 A;  5U26 A;  3I8A X;  4QJZ D;  3NXR A;  3QL3 A;  3QLZ A;  1KLK A;  4KLX A;  4OSG A;  3SR5 X;  3I3R A;  2OBC A;  3F91 A;  4HA7 A;  1LY3 A;  1RA1 A;  1DRB A;  4H96 A;  3NZD A;  3E0B A;  2XW7 A;  1HFQ A;  3CL9 A;  3L3R A;  4LAG X;  1DRH A;  4P3Q A;  3TQA A;  1S3V A;  4EJ1 A;  3F0U X;  3KJS A;  3FY8 X;  4ELF A;  4TU5 X;  3GHC A;  4Q67 A;  4KM2 A;  3GI2 A;  2G6V A;  4HOE A;  4PDJ A;  1VJ3 A;  3SRQ X;  3M08 A;  3SGY A;  4KL9 A;  2P4G A;  1M78 A;  2FZJ A;  2HM9 A;  3SRW X;  1D1G A;  4KJJ A;  5HQZ A;  4HOG A;  5HSU A;  3QLW A;  3ZPC A;  4XT8 A;  3NU0 A;  3EEJ A;  3NXV A;  4KJK A;  3CSE A;  1DR4 A;  3JWM A;  5CC9 A;  1AO8 A;  2FZI A;  4PST A;  1PDB A;  4GH8 A;  4XE6 X;  1HFR A;  1RX6 A;  3EEK A;  4ECK A;  3QG2 A;  5HQY A;  3DL5 A;  2OIP A;  1M79 A;  1HFP A;  1DYR A;  4XRB A;  2DHF A;  4KEB A;  5HUI A; 
#chains in the Genus database with same CATH topology
 4DDR A;  1AI9 A;  4M7U A;  1DHI A;  2B3Z A;  1S3Y A;  3NZC X;  4Q6A A;  1U72 A;  2W3V A;  5HPB A;  4X5I A;  3F8Y A;  3FYW X;  1ZDR A;  4M7V A;  2CIG A;  1OHJ A;  1DG5 A;  1DHF A;  2W3M A;  3FYV X;  3NTZ A;  3S3V A;  4P68 A;  1DIS A;  3F0S X;  3SRR X;  1DG8 A;  2DRC A;  3KY8 A;  1DYI A;  3RO9 A;  3K45 A;  3SA2 A;  2BLB A;  1JOM A;  3LG4 A;  3JTW A;  3NRR A;  1RX3 A;  3VCO A;  3DAU A;  2FZH A;  1LUD A;  3FRE X;  3QYL A;  4I13 A;  4QI9 A;  4I1N A;  1RX5 A;  4FGG A;  1RB3 A;  4P66 A;  3TD8 A;  1DDS A;  1RX4 A;  3F0B X;  4QLF A;  3JWC A;  3R33 A;  4HOF A;  5DFR A;  1DLS A;  4G95 A;  2ITH A;  4H95 A;  5JA3 A;  4KD7 A;  1M7A A;  1QZF A;  4QLG A;  1DYJ A;  5U27 A;  1IA3 A;  2BL9 A;  3EX8 A;  3GYF A;  1J3K A;  1DR7 A;  2C2S A;  3SQY X;  3IRO A;  3DAT A;  1RX1 A;  3JVX A;  1RX9 A;  3FL9 A;  3M09 A;  1RC4 A;  3QFX A;  1DLR A;  3JW3 A;  5HT4 A;  1CD2 A;  3GHW A;  4DFR A;  4OR7 A;  1DIU A;  2W3B A;  3TQ9 A;  2GD9 A;  2QK8 A;  4G8Z X;  4QJC A;  4M6K A;  4KY8 A;  4M2X A;  4NX6 A;  1BZF A;  5ECC A;  4KBN A;  3QLY A;  4IXG X;  3IA4 A;  1KMV A;  3S7A A;  3S9U A;  3DG8 A;  3ROA A;  1J3J A;  2BLA A;  5E8Q A;  3FQV A;  3NZB X;  3QLS A;  1E26 A;  8DFR A;  1CZ3 A;  5HI6 A;  1MVS A;  2KGK A;  1RF7 A;  3INV A;  2CD2 A;  1RA8 A;  3FRA X;  5HVE A;  2ANO A;  4X5G A;  3RG9 A;  3FRB X;  4PTH A;  3JWF A;  1KMS A;  4XEC X;  1RX8 A;  4EIZ A;  1PD9 A;  1S3U A;  3F0V X;  3EEM A;  1DR5 A;  1LY4 A;  4X5F A;  5DXV A;  4H98 A;  1RH3 A;  3NZA X;  1S3W A;  5HT5 A;  5FDA A;  4EIL A;  1DAJ A;  1IA2 A;  2L28 A;  3QYO A;  4IXF X;  5CCC A;  2H2Q A;  4KJL A;  1RX2 A;  2C2T A;  1DYH A;  3K2H A;  1DR1 A;  3FQ0 A;  4HA9 A;  3EEL A;  1JOL A;  1PD8 A;  4H97 A;  3JW5 A;  3K74 A;  2AZN A;  3UM8 A;  2W9G A;  3JWK A;  5JG0 X;  3DRC A;  4CD2 A;  3NXX A;  4X5J A;  1IA4 A;  3NZ9 X;  3D84 X;  5ECX A;  1RE7 A;  6DFR A;  2ANQ A;  4KAK A;  3GHV A;  3NXT A;  3IRN A;  3QLR A;  1IA1 A;  4ELB A;  1SEJ A;  3FRD X;  4NX7 A;  5HF2 X;  4LEK X;  2HQP A;  4XT7 A;  3KJR A;  1RA3 A;  1DDR A;  4Q0D A;  3QL0 A;  2W9S A;  1YHO A;  4FGH A;  4LAE X;  4QLE A;  3K47 A;  3FQZ A;  1DRE A;  3FY9 X;  3NZ6 X;  4G3M A;  1DRA A;  7DFR A;  4EIG A;  3IA5 A;  3SA1 A;  4ELG A;  3KFY A;  4DPD A;  4KM0 A;  3UM6 A;  4FHB A;  4DP3 A;  3F0Q X;  1AOE A;  3CLB A;  3HBB A;  3HJ3 A;  3FQC A;  2W9T A;  1DR3 A;  3SH2 A;  3SRU X;  1J3I A;  5EAJ A;  3FL8 A;  3N0H A;  2W3W A;  2O7P A;  4LAH X;  2LF1 A;  3SAI A;  3F0X X;  5HSR A;  5HVB A;  1DR2 A;  2ZZA A;  3FS6 A;  4Q0E A;  4M6J A;  4KY4 A;  3FQO A;  3Q1H A;  3TQ8 A;  1DRF A;  2W3A A;  3D80 A;  4ELH A;  1MVT A;  1RD7 A;  4XT5 A;  3CD2 A;  4PTJ A;  1DF7 A;  3DFR A;  3DGA A;  4M6L A;  4ELE A;  3TQB A;  1U71 A;  2BLC A;  3QLX A;  2JYB A;  1RX7 A;  1VDR A;  2D0K A;  3KGY A;  4PSY A;  4XT6 A;  4P3R A;  4DPH A;  3EIG A;  3OCH A;  1DR6 A;  3UM5 A;  1RA2 A;  4KYA A;  1JUV A;  3DL6 A;  3QGT A;  4PSS A;  1DHJ A;  1BOZ A;  4QHV A;  1RG7 A;  3F8Z A;  4IXE D;  4X5H A;  1TDR A;  1RA9 A;  3JSU A;  3NXO A;  3ZPG A;  4KNE A;  3SRS X;  3IX9 A;  4KFJ A;  5HF0 X;  1U70 A;  1RB2 A;  1OHK A;  2HXV A;  3FQF A;  2D5N A;  2INQ A;  3IRM A;  3FRF X;  2W9H A;  3OAF A;  1DG7 A;  4RGC A;  3NXY A;  4XT4 A;  5U26 A;  3I8A X;  4QJZ D;  3NXR A;  3QL3 A;  3QLZ A;  1KLK A;  4KLX A;  4OSG A;  3SR5 X;  3I3R A;  2OBC A;  3F91 A;  4HA7 A;  1LY3 A;  1RA1 A;  1DRB A;  4H96 A;  3NZD A;  3E0B A;  2XW7 A;  1HFQ A;  3CL9 A;  3L3R A;  4LAG X;  1DRH A;  4P3Q A;  3TQA A;  1S3V A;  4EJ1 A;  3F0U X;  3KJS A;  3FY8 X;  4ELF A;  4TU5 X;  3GHC A;  4Q67 A;  4KM2 A;  3GI2 A;  2G6V A;  4HOE A;  4PDJ A;  1VJ3 A;  3SRQ X;  3M08 A;  3SGY A;  4KL9 A;  2P4G A;  1M78 A;  2FZJ A;  2HM9 A;  3SRW X;  1D1G A;  4KJJ A;  5HQZ A;  4HOG A;  5HSU A;  3QLW A;  3ZPC A;  4XT8 A;  3NU0 A;  3EEJ A;  3NXV A;  4KJK A;  3CSE A;  1DR4 A;  3JWM A;  5CC9 A;  1AO8 A;  2FZI A;  4PST A;  1PDB A;  4GH8 A;  4XE6 X;  1HFR A;  1RX6 A;  3EEK A;  4ECK A;  3QG2 A;  5HQY A;  3DL5 A;  2OIP A;  1M79 A;  1HFP A;  1DYR A;  4XRB A;  2DHF A;  4KEB A;  5HUI A; 
#chains in the Genus database with same CATH homology
 4DDR A;  1AI9 A;  4M7U A;  1DHI A;  2B3Z A;  1S3Y A;  3NZC X;  4Q6A A;  1U72 A;  2W3V A;  5HPB A;  4X5I A;  3F8Y A;  3FYW X;  1ZDR A;  4M7V A;  2CIG A;  1OHJ A;  1DG5 A;  1DHF A;  2W3M A;  3FYV X;  3NTZ A;  3S3V A;  4P68 A;  1DIS A;  3F0S X;  3SRR X;  1DG8 A;  2DRC A;  3KY8 A;  1DYI A;  3RO9 A;  3K45 A;  3SA2 A;  2BLB A;  1JOM A;  3LG4 A;  3JTW A;  3NRR A;  1RX3 A;  3VCO A;  3DAU A;  2FZH A;  1LUD A;  3FRE X;  3QYL A;  4I13 A;  4QI9 A;  4I1N A;  1RX5 A;  4FGG A;  1RB3 A;  4P66 A;  3TD8 A;  1DDS A;  1RX4 A;  3F0B X;  4QLF A;  3JWC A;  3R33 A;  4HOF A;  5DFR A;  1DLS A;  4G95 A;  2ITH A;  4H95 A;  5JA3 A;  4KD7 A;  1M7A A;  1QZF A;  4QLG A;  1DYJ A;  5U27 A;  1IA3 A;  2BL9 A;  3EX8 A;  3GYF A;  1J3K A;  1DR7 A;  2C2S A;  3SQY X;  3IRO A;  3DAT A;  1RX1 A;  3JVX A;  1RX9 A;  3FL9 A;  3M09 A;  1RC4 A;  3QFX A;  1DLR A;  3JW3 A;  5HT4 A;  1CD2 A;  3GHW A;  4DFR A;  4OR7 A;  1DIU A;  2W3B A;  3TQ9 A;  2GD9 A;  2QK8 A;  4G8Z X;  4QJC A;  4M6K A;  4KY8 A;  4M2X A;  4NX6 A;  1BZF A;  5ECC A;  4KBN A;  3QLY A;  4IXG X;  3IA4 A;  1KMV A;  3S7A A;  3S9U A;  3DG8 A;  3ROA A;  1J3J A;  2BLA A;  5E8Q A;  3FQV A;  3NZB X;  3QLS A;  1E26 A;  8DFR A;  1CZ3 A;  5HI6 A;  1MVS A;  2KGK A;  1RF7 A;  3INV A;  2CD2 A;  1RA8 A;  3FRA X;  5HVE A;  2ANO A;  4X5G A;  3RG9 A;  3FRB X;  4PTH A;  3JWF A;  1KMS A;  4XEC X;  1RX8 A;  4EIZ A;  1PD9 A;  1S3U A;  3F0V X;  3EEM A;  1DR5 A;  1LY4 A;  4X5F A;  5DXV A;  4H98 A;  1RH3 A;  3NZA X;  1S3W A;  5HT5 A;  5FDA A;  4EIL A;  1DAJ A;  1IA2 A;  2L28 A;  3QYO A;  4IXF X;  5CCC A;  2H2Q A;  4KJL A;  1RX2 A;  2C2T A;  1DYH A;  3K2H A;  1DR1 A;  3FQ0 A;  4HA9 A;  3EEL A;  1JOL A;  1PD8 A;  4H97 A;  3JW5 A;  3K74 A;  2AZN A;  3UM8 A;  2W9G A;  3JWK A;  5JG0 X;  3DRC A;  4CD2 A;  3NXX A;  4X5J A;  1IA4 A;  3NZ9 X;  3D84 X;  5ECX A;  1RE7 A;  6DFR A;  2ANQ A;  4KAK A;  3GHV A;  3NXT A;  3IRN A;  3QLR A;  1IA1 A;  4ELB A;  1SEJ A;  3FRD X;  4NX7 A;  5HF2 X;  4LEK X;  2HQP A;  4XT7 A;  3KJR A;  1RA3 A;  1DDR A;  4Q0D A;  3QL0 A;  2W9S A;  1YHO A;  4FGH A;  4LAE X;  4QLE A;  3K47 A;  3FQZ A;  1DRE A;  3FY9 X;  3NZ6 X;  4G3M A;  1DRA A;  7DFR A;  4EIG A;  3IA5 A;  3SA1 A;  4ELG A;  3KFY A;  4DPD A;  4KM0 A;  3UM6 A;  4FHB A;  4DP3 A;  3F0Q X;  1AOE A;  3CLB A;  3HBB A;  3HJ3 A;  3FQC A;  2W9T A;  1DR3 A;  3SH2 A;  3SRU X;  1J3I A;  5EAJ A;  3FL8 A;  3N0H A;  2W3W A;  2O7P A;  4LAH X;  2LF1 A;  3SAI A;  3F0X X;  5HSR A;  5HVB A;  1DR2 A;  2ZZA A;  3FS6 A;  4Q0E A;  4M6J A;  4KY4 A;  3FQO A;  3Q1H A;  3TQ8 A;  1DRF A;  2W3A A;  3D80 A;  4ELH A;  1MVT A;  1RD7 A;  4XT5 A;  3CD2 A;  4PTJ A;  1DF7 A;  3DFR A;  3DGA A;  4M6L A;  4ELE A;  3TQB A;  1U71 A;  2BLC A;  3QLX A;  2JYB A;  1RX7 A;  1VDR A;  2D0K A;  3KGY A;  4PSY A;  4XT6 A;  4P3R A;  4DPH A;  3EIG A;  3OCH A;  1DR6 A;  3UM5 A;  1RA2 A;  4KYA A;  1JUV A;  3DL6 A;  3QGT A;  4PSS A;  1DHJ A;  1BOZ A;  4QHV A;  1RG7 A;  3F8Z A;  4IXE D;  4X5H A;  1TDR A;  1RA9 A;  3JSU A;  3NXO A;  3ZPG A;  4KNE A;  3SRS X;  3IX9 A;  4KFJ A;  5HF0 X;  1U70 A;  1RB2 A;  1OHK A;  2HXV A;  3FQF A;  2D5N A;  2INQ A;  3IRM A;  3FRF X;  2W9H A;  3OAF A;  1DG7 A;  4RGC A;  3NXY A;  4XT4 A;  5U26 A;  3I8A X;  4QJZ D;  3NXR A;  3QL3 A;  3QLZ A;  1KLK A;  4KLX A;  4OSG A;  3SR5 X;  3I3R A;  2OBC A;  3F91 A;  4HA7 A;  1LY3 A;  1RA1 A;  1DRB A;  4H96 A;  3NZD A;  3E0B A;  2XW7 A;  1HFQ A;  3CL9 A;  3L3R A;  4LAG X;  1DRH A;  4P3Q A;  3TQA A;  1S3V A;  4EJ1 A;  3F0U X;  3KJS A;  3FY8 X;  4ELF A;  4TU5 X;  3GHC A;  4Q67 A;  4KM2 A;  3GI2 A;  2G6V A;  4HOE A;  4PDJ A;  1VJ3 A;  3SRQ X;  3M08 A;  3SGY A;  4KL9 A;  2P4G A;  1M78 A;  2FZJ A;  2HM9 A;  3SRW X;  1D1G A;  4KJJ A;  5HQZ A;  4HOG A;  5HSU A;  3QLW A;  3ZPC A;  4XT8 A;  3NU0 A;  3EEJ A;  3NXV A;  4KJK A;  3CSE A;  1DR4 A;  3JWM A;  5CC9 A;  1AO8 A;  2FZI A;  4PST A;  1PDB A;  4GH8 A;  4XE6 X;  1HFR A;  1RX6 A;  3EEK A;  4ECK A;  3QG2 A;  5HQY A;  3DL5 A;  2OIP A;  1M79 A;  1HFP A;  1DYR A;  4XRB A;  2DHF A;  4KEB A;  5HUI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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