3FRFX

S. aureus dhfr complexed with nadph and iclaprim
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
158
structure length
158
Chain Sequence
TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Staphylococcus aureus
molecule keywords Dihydrofolate reductase
total genus 41
structure length 158
sequence length 158
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3frfX00
4DFRA 1DRHA 2DRCA 1HFQA 4KL9A 1D1GA 3IA4A 1DG8A 4QLGA 1OHJA 2AZNA 5EAJA 3RO9A 3OAFA 3FRAX 3NZCX 1BOZA 1AOEA 3UM5A 1RX9A 1KLKA 3F0BX 3K74A 1DR2A 4P3QA 2ITHA 5HUIA 4QLEA 3F0VX 5CCCA 4G3MA 1E26A 1RX5A 3GHWA 4G95A 4KYAA 5ECCA 3F8ZA 4LEKX 3FRFX 4Q0DA 3CLBA 1DR5A 3SH2A 3SQYX 5HQZA 3NXRA 3DL6A 4HA9A 1DAJA 7DFRA 2G6VA 4EIGA 3JTWA 4I1NA 2BLAA 4M2XA 4LAGX 4FGGA 4KD7A 3FRDX 3GHCA 1RX6A 1J3JA 3IX9A 2W3AA 8DFRA 2HQPA 1RF7A 1MVTA 4M6KA 1RC4A 4HA7A 3EX8A 1DRBA 3NZ6X 4KBNA 2XW7A 3ROAA 1J3KA 3EEJA 3TQ8A 2W3MA 4PSYA 3TD8A 3GYFA 3CD2A 3F0UX 3F0SX 3NXXA 4QJZD 5E8QA 4XT8A 4HOEA 4H96A 4IXED 3SA1A 3FQ0A 1RD7A 3HBBA 1KMVA 3FQOA 4ELGA 4ELBA 3JWCA 4P3RA 4X5JA 3SRUX 3NXYA 3VCOA 3ZPGA 4KJKA 4XRBA 3I8AX 3DAUA 2W9SA 3QYOA 3JWMA 2W9TA 4QLFA 1DRFA 4Q0EA 1HFRA 1RB3A 3TQ9A 3NU0A 4KM0A 3FL9A 1IA4A 3QLYA 1CD2A 3JSUA 2CD2A 3TQAA 1IA2A 1RX8A 4PDJA 4EILA 1DYIA 2FZIA 1DR3A 5HSUA 1DHFA 4H97A 1DR6A 4XT4A 1RX3A 3OCHA 2BL9A 1HFPA 4TU5X 4LAHX 1S3WA 5JA3A 2HM9A 5CC9A 2KGKA 2FZHA 4OSGA 4G8ZX 3EEKA 4H98A 3D80A 4PTHA 1TDRA 1MVSA 2DHFA 3F91A 5HI6A 1JOLA 3FS6A 1ZDRA 1RA1A 2ZZAA 4KLXA 1DR1A 4ELFA 1U72A 3FRBX 4CD2A 3KJRA 4KJLA 1J3IA 2C2TA 3SRRX 3I3RA 3JW5A 4KY4A 4XT7A 1RX7A 1RA3A 4IXFX 1DHIA 2P4GA 1DRAA 3QFXA 1DYRA 1DR7A 1AO8A 4ELHA 3UM8A 2OIPA 4PSSA 3RG9A 1OHKA 3S7AA 1RA2A 2W3WA 4LAEX 1IA3A 6DFRA 3SR5X 5DXVA 1PD9A 5HT4A 3IROA 1DG7A 1RX2A 1DLSA 2O7PA 1RB2A 3FQZA 3JWFA 3NRRA 3SGYA 3K45A 3D84X 3DL5A 4XECX 3M08A 3R33A 3NXVA 1LUDA 2QK8A 2INQA 5HSRA 3NZDA 3QG2A 3F0QX 1JOMA 1U70A 3CSEA 3QL3A 3GHVA 3NTZA 3SAIA 2BLCA 2JYBA 4EJ1A 3S9UA 3NZBX 3IA5A 3KJSA 1S3UA 4X5GA 1LY3A 2D5NA 3QLRA 2W3BA 5ECXA 4HOFA 5HVEA 1DDRA 3FQFA 3SRSX 4KAKA 4DDRA 3DRCA 4KM2A 4KFJA 3E0BA 3NZAX 4RGCA 3NXOA 3IRNA 2LF1A 2W9HA 3DGAA 3FL8A 3FYWX 5HQYA 5U27A 4ECKA 1RX1A 3QYLA 4OR7A 4H95A 1DYJA 1RA8A 3HJ3A 4HOGA 3KGYA 4XE6X 2CIGA 1PD8A 3DG8A 1PDBA 3FQCA 3CL9A 4X5IA 3FREX 3K2HA 5HF2X 1JUVA 1DIUA 3LG4A 3JWKA 3QLZA 4IXGX 2BLBA 1RE7A 3NZ9X 3FY9X 3KFYA 2H2QA 4EIZA 5HPBA 3M09A 4FGHA 2W3VA 2D0KA 4M6LA 4NX6A 5HT5A 1RH3A 4XT5A 1YHOA 3S3VA 3ZPCA 3SRQX 1RX4A 1VJ3A 1AI9A 1M79A 3DFRA 1RG7A 1DR4A 1DISA 1QZFA 2HXVA 4ELEA 1LY4A 1DHJA 2GD9A 5U26A 2FZJA 4X5HA 1CZ3A 3GI2A 4KJJA 5DFRA 1M78A 3FYVX 3Q1HA 3QGTA 4KNEA 2ANOA 4DPDA 3DATA 3K47A 2L28A 4X5FA 1IA1A 1S3VA 4M7UA 4I13A 1SEJA 3N0HA 2W9GA 1BZFA 1DLRA 4DP3A 1DREA 4QJCA 1DDSA 4QI9A 1VDRA 2ANQA 2C2SA 3EEMA 5HVBA 1DG5A 4M6JA 1U71A 4KY8A 3UM6A 5HF0X 3INVA 4P66A 4Q6AA 3SRWX 5JG0X 4FHBA 4KEBA 3QLSA 2OBCA 3F0XX 4PTJA 1S3YA 3JVXA 1RA9A 1DF7A 3FY8X 4DPHA 2B3ZA 5FDAA 3QLWA 4Q67A 4XT6A 3EIGA 3QLXA 4M7VA 3F8YA 1DYHA 4P68A 3KY8A 3IRMA 3TQBA 3L3RA 1KMSA 3SA2A 3JW3A 4PSTA 3EELA 4GH8A 4QHVA 3QL0A 1M7AA 3NXTA 3FQVA 4NX7A
chains in the Genus database with same CATH superfamily
4DFRA 1DRHA 2DRCA 1HFQA 4KL9A 1D1GA 3IA4A 1DG8A 4QLGA 1OHJA 2AZNA 5EAJA 3RO9A 3OAFA 3FRAX 3NZCX 1BOZA 1AOEA 3UM5A 1RX9A 1KLKA 3F0BX 3K74A 1DR2A 4P3QA 2ITHA 5HUIA 4QLEA 3F0VX 5CCCA 4G3MA 1E26A 1RX5A 3GHWA 4G95A 4KYAA 5ECCA 3F8ZA 4LEKX 3FRFX 4Q0DA 3CLBA 1DR5A 3SH2A 3SQYX 5HQZA 3NXRA 3DL6A 4HA9A 1DAJA 7DFRA 2G6VA 4EIGA 3JTWA 4I1NA 2BLAA 4M2XA 4LAGX 4FGGA 4KD7A 3FRDX 3GHCA 1RX6A 1J3JA 3IX9A 2W3AA 8DFRA 2HQPA 1RF7A 1MVTA 4M6KA 1RC4A 4HA7A 3EX8A 1DRBA 3NZ6X 4KBNA 2XW7A 3ROAA 1J3KA 3EEJA 3TQ8A 2W3MA 4PSYA 3TD8A 3GYFA 3CD2A 3F0UX 3F0SX 3NXXA 4QJZD 5E8QA 4XT8A 4HOEA 4H96A 4IXED 3SA1A 3FQ0A 1RD7A 3HBBA 1KMVA 3FQOA 4ELGA 4ELBA 3JWCA 4P3RA 4X5JA 3SRUX 3NXYA 3VCOA 3ZPGA 4KJKA 4XRBA 3I8AX 3DAUA 2W9SA 3QYOA 3JWMA 2W9TA 4QLFA 1DRFA 4Q0EA 1HFRA 1RB3A 3TQ9A 3NU0A 4KM0A 3FL9A 1IA4A 3QLYA 1CD2A 3JSUA 2CD2A 3TQAA 1IA2A 1RX8A 4PDJA 4EILA 1DYIA 2FZIA 1DR3A 5HSUA 1DHFA 4H97A 1DR6A 4XT4A 1RX3A 3OCHA 2BL9A 1HFPA 4TU5X 4LAHX 1S3WA 5JA3A 2HM9A 5CC9A 2KGKA 2FZHA 4OSGA 4G8ZX 3EEKA 4H98A 3D80A 4PTHA 1TDRA 1MVSA 2DHFA 3F91A 5HI6A 1JOLA 3FS6A 1ZDRA 1RA1A 2ZZAA 4KLXA 1DR1A 4ELFA 1U72A 3FRBX 4CD2A 3KJRA 4KJLA 1J3IA 2C2TA 3SRRX 3I3RA 3JW5A 4KY4A 4XT7A 1RX7A 1RA3A 4IXFX 1DHIA 2P4GA 1DRAA 3QFXA 1DYRA 1DR7A 1AO8A 4ELHA 3UM8A 2OIPA 4PSSA 3RG9A 1OHKA 3S7AA 1RA2A 2W3WA 4LAEX 1IA3A 6DFRA 3SR5X 5DXVA 1PD9A 5HT4A 3IROA 1DG7A 1RX2A 1DLSA 2O7PA 1RB2A 3FQZA 3JWFA 3NRRA 3SGYA 3K45A 3D84X 3DL5A 4XECX 3M08A 3R33A 3NXVA 1LUDA 2QK8A 2INQA 5HSRA 3NZDA 3QG2A 3F0QX 1JOMA 1U70A 3CSEA 3QL3A 3GHVA 3NTZA 3SAIA 2BLCA 2JYBA 4EJ1A 3S9UA 3NZBX 3IA5A 3KJSA 1S3UA 4X5GA 1LY3A 2D5NA 3QLRA 2W3BA 5ECXA 4HOFA 5HVEA 1DDRA 3FQFA 3SRSX 4KAKA 4DDRA 3DRCA 4KM2A 4KFJA 3E0BA 3NZAX 4RGCA 3NXOA 3IRNA 2LF1A 2W9HA 3DGAA 3FL8A 3FYWX 5HQYA 5U27A 4ECKA 1RX1A 3QYLA 4OR7A 4H95A 1DYJA 1RA8A 3HJ3A 4HOGA 3KGYA 4XE6X 2CIGA 1PD8A 3DG8A 1PDBA 3FQCA 3CL9A 4X5IA 3FREX 3K2HA 5HF2X 1JUVA 1DIUA 3LG4A 3JWKA 3QLZA 4IXGX 2BLBA 1RE7A 3NZ9X 3FY9X 3KFYA 2H2QA 4EIZA 5HPBA 3M09A 4FGHA 2W3VA 2D0KA 4M6LA 4NX6A 5HT5A 1RH3A 4XT5A 1YHOA 3S3VA 3ZPCA 3SRQX 1RX4A 1VJ3A 1AI9A 1M79A 3DFRA 1RG7A 1DR4A 1DISA 1QZFA 2HXVA 4ELEA 1LY4A 1DHJA 2GD9A 5U26A 2FZJA 4X5HA 1CZ3A 3GI2A 4KJJA 5DFRA 1M78A 3FYVX 3Q1HA 3QGTA 4KNEA 2ANOA 4DPDA 3DATA 3K47A 2L28A 4X5FA 1IA1A 1S3VA 4M7UA 4I13A 1SEJA 3N0HA 2W9GA 1BZFA 1DLRA 4DP3A 1DREA 4QJCA 1DDSA 4QI9A 1VDRA 2ANQA 2C2SA 3EEMA 5HVBA 1DG5A 4M6JA 1U71A 4KY8A 3UM6A 5HF0X 3INVA 4P66A 4Q6AA 3SRWX 5JG0X 4FHBA 4KEBA 3QLSA 2OBCA 3F0XX 4PTJA 1S3YA 3JVXA 1RA9A 1DF7A 3FY8X 4DPHA 2B3ZA 5FDAA 3QLWA 4Q67A 4XT6A 3EIGA 3QLXA 4M7VA 3F8YA 1DYHA 4P68A 3KY8A 3IRMA 3TQBA 3L3RA 1KMSA 3SA2A 3JW3A 4PSTA 3EELA 4GH8A 4QHVA 3QL0A 1M7AA 3NXTA 3FQVA 4NX7A
chains in the Genus database with same CATH topology
4DFRA 1DRHA 2DRCA 1HFQA 4KL9A 1D1GA 3IA4A 1DG8A 4QLGA 1OHJA 2AZNA 5EAJA 3RO9A 3OAFA 3FRAX 3NZCX 1BOZA 1AOEA 3UM5A 1RX9A 1KLKA 3F0BX 3K74A 1DR2A 4P3QA 2ITHA 5HUIA 4QLEA 3F0VX 5CCCA 4G3MA 1E26A 1RX5A 3GHWA 4G95A 4KYAA 5ECCA 3F8ZA 4LEKX 3FRFX 4Q0DA 3CLBA 1DR5A 3SH2A 3SQYX 5HQZA 3NXRA 3DL6A 4HA9A 1DAJA 7DFRA 2G6VA 4EIGA 3JTWA 4I1NA 2BLAA 4M2XA 4LAGX 4FGGA 4KD7A 3FRDX 3GHCA 1RX6A 1J3JA 3IX9A 2W3AA 8DFRA 2HQPA 1RF7A 1MVTA 4M6KA 1RC4A 4HA7A 3EX8A 1DRBA 3NZ6X 4KBNA 2XW7A 3ROAA 1J3KA 3EEJA 3TQ8A 2W3MA 4PSYA 3TD8A 3GYFA 3CD2A 3F0UX 3F0SX 3NXXA 4QJZD 5E8QA 4XT8A 4HOEA 4H96A 4IXED 3SA1A 3FQ0A 1RD7A 3HBBA 1KMVA 3FQOA 4ELGA 4ELBA 3JWCA 4P3RA 4X5JA 3SRUX 3NXYA 3VCOA 3ZPGA 4KJKA 4XRBA 3I8AX 3DAUA 2W9SA 3QYOA 3JWMA 2W9TA 4QLFA 1DRFA 4Q0EA 1HFRA 1RB3A 3TQ9A 3NU0A 4KM0A 3FL9A 1IA4A 3QLYA 1CD2A 3JSUA 2CD2A 3TQAA 1IA2A 1RX8A 4PDJA 4EILA 1DYIA 2FZIA 1DR3A 5HSUA 1DHFA 4H97A 1DR6A 4XT4A 1RX3A 3OCHA 2BL9A 1HFPA 4TU5X 4LAHX 1S3WA 5JA3A 2HM9A 5CC9A 2KGKA 2FZHA 4OSGA 4G8ZX 3EEKA 4H98A 3D80A 4PTHA 1TDRA 1MVSA 2DHFA 3F91A 5HI6A 1JOLA 3FS6A 1ZDRA 1RA1A 2ZZAA 4KLXA 1DR1A 4ELFA 1U72A 3FRBX 4CD2A 3KJRA 4KJLA 1J3IA 2C2TA 3SRRX 3I3RA 3JW5A 4KY4A 4XT7A 1RX7A 1RA3A 4IXFX 1DHIA 2P4GA 1DRAA 3QFXA 1DYRA 1DR7A 1AO8A 4ELHA 3UM8A 2OIPA 4PSSA 3RG9A 1OHKA 3S7AA 1RA2A 2W3WA 4LAEX 1IA3A 6DFRA 3SR5X 5DXVA 1PD9A 5HT4A 3IROA 1DG7A 1RX2A 1DLSA 2O7PA 1RB2A 3FQZA 3JWFA 3NRRA 3SGYA 3K45A 3D84X 3DL5A 4XECX 3M08A 3R33A 3NXVA 1LUDA 2QK8A 2INQA 5HSRA 3NZDA 3QG2A 3F0QX 1JOMA 1U70A 3CSEA 3QL3A 3GHVA 3NTZA 3SAIA 2BLCA 2JYBA 4EJ1A 3S9UA 3NZBX 3IA5A 3KJSA 1S3UA 4X5GA 1LY3A 2D5NA 3QLRA 2W3BA 5ECXA 4HOFA 5HVEA 1DDRA 3FQFA 3SRSX 4KAKA 4DDRA 3DRCA 4KM2A 4KFJA 3E0BA 3NZAX 4RGCA 3NXOA 3IRNA 2LF1A 2W9HA 3DGAA 3FL8A 3FYWX 5HQYA 5U27A 4ECKA 1RX1A 3QYLA 4OR7A 4H95A 1DYJA 1RA8A 3HJ3A 4HOGA 3KGYA 4XE6X 2CIGA 1PD8A 3DG8A 1PDBA 3FQCA 3CL9A 4X5IA 3FREX 3K2HA 5HF2X 1JUVA 1DIUA 3LG4A 3JWKA 3QLZA 4IXGX 2BLBA 1RE7A 3NZ9X 3FY9X 3KFYA 2H2QA 4EIZA 5HPBA 3M09A 4FGHA 2W3VA 2D0KA 4M6LA 4NX6A 5HT5A 1RH3A 4XT5A 1YHOA 3S3VA 3ZPCA 3SRQX 1RX4A 1VJ3A 1AI9A 1M79A 3DFRA 1RG7A 1DR4A 1DISA 1QZFA 2HXVA 4ELEA 1LY4A 1DHJA 2GD9A 5U26A 2FZJA 4X5HA 1CZ3A 3GI2A 4KJJA 5DFRA 1M78A 3FYVX 3Q1HA 3QGTA 4KNEA 2ANOA 4DPDA 3DATA 3K47A 2L28A 4X5FA 1IA1A 1S3VA 4M7UA 4I13A 1SEJA 3N0HA 2W9GA 1BZFA 1DLRA 4DP3A 1DREA 4QJCA 1DDSA 4QI9A 1VDRA 2ANQA 2C2SA 3EEMA 5HVBA 1DG5A 4M6JA 1U71A 4KY8A 3UM6A 5HF0X 3INVA 4P66A 4Q6AA 3SRWX 5JG0X 4FHBA 4KEBA 3QLSA 2OBCA 3F0XX 4PTJA 1S3YA 3JVXA 1RA9A 1DF7A 3FY8X 4DPHA 2B3ZA 5FDAA 3QLWA 4Q67A 4XT6A 3EIGA 3QLXA 4M7VA 3F8YA 1DYHA 4P68A 3KY8A 3IRMA 3TQBA 3L3RA 1KMSA 3SA2A 3JW3A 4PSTA 3EELA 4GH8A 4QHVA 3QL0A 1M7AA 3NXTA 3FQVA 4NX7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DFR A;  1DRH A;  2DRC A;  1HFQ A;  4KL9 A;  1D1G A;  3IA4 A;  1DG8 A;  4QLG A;  1OHJ A;  2AZN A;  5EAJ A;  3RO9 A;  3OAF A;  3FRA X;  3NZC X;  1BOZ A;  1AOE A;  3UM5 A;  1RX9 A;  1KLK A;  3F0B X;  3K74 A;  1DR2 A;  4P3Q A;  2ITH A;  5HUI A;  4QLE A;  3F0V X;  5CCC A;  4G3M A;  1E26 A;  1RX5 A;  3GHW A;  4G95 A;  4KYA A;  5ECC A;  3F8Z A;  4LEK X;  3FRF X;  4Q0D A;  3CLB A;  1DR5 A;  3SH2 A;  3SQY X;  5HQZ A;  3NXR A;  3DL6 A;  4HA9 A;  1DAJ A;  7DFR A;  2G6V A;  4EIG A;  3JTW A;  4I1N A;  2BLA A;  4M2X A;  4LAG X;  4FGG A;  4KD7 A;  3FRD X;  3GHC A;  1RX6 A;  1J3J A;  3IX9 A;  2W3A A;  8DFR A;  2HQP A;  1RF7 A;  1MVT A;  4M6K A;  1RC4 A;  4HA7 A;  3EX8 A;  1DRB A;  3NZ6 X;  4KBN A;  2XW7 A;  3ROA A;  1J3K A;  3EEJ A;  3TQ8 A;  2W3M A;  4PSY A;  3TD8 A;  3GYF A;  3CD2 A;  3F0U X;  3F0S X;  3NXX A;  4QJZ D;  5E8Q A;  4XT8 A;  4HOE A;  4H96 A;  4IXE D;  3SA1 A;  3FQ0 A;  1RD7 A;  3HBB A;  1KMV A;  3FQO A;  4ELG A;  4ELB A;  3JWC A;  4P3R A;  4X5J A;  3SRU X;  3NXY A;  3VCO A;  3ZPG A;  4KJK A;  4XRB A;  3I8A X;  3DAU A;  2W9S A;  3QYO A;  3JWM A;  2W9T A;  4QLF A;  1DRF A;  4Q0E A;  1HFR A;  1RB3 A;  3TQ9 A;  3NU0 A;  4KM0 A;  3FL9 A;  1IA4 A;  3QLY A;  1CD2 A;  3JSU A;  2CD2 A;  3TQA A;  1IA2 A;  1RX8 A;  4PDJ A;  4EIL A;  1DYI A;  2FZI A;  1DR3 A;  5HSU A;  1DHF A;  4H97 A;  1DR6 A;  4XT4 A;  1RX3 A;  3OCH A;  2BL9 A;  1HFP A;  4TU5 X;  4LAH X;  1S3W A;  5JA3 A;  2HM9 A;  5CC9 A;  2KGK A;  2FZH A;  4OSG A;  4G8Z X;  3EEK A;  4H98 A;  3D80 A;  4PTH A;  1TDR A;  1MVS A;  2DHF A;  3F91 A;  5HI6 A;  1JOL A;  3FS6 A;  1ZDR A;  1RA1 A;  2ZZA A;  4KLX A;  1DR1 A;  4ELF A;  1U72 A;  3FRB X;  4CD2 A;  3KJR A;  4KJL A;  1J3I A;  2C2T A;  3SRR X;  3I3R A;  3JW5 A;  4KY4 A;  4XT7 A;  1RX7 A;  1RA3 A;  4IXF X;  1DHI A;  2P4G A;  1DRA A;  3QFX A;  1DYR A;  1DR7 A;  1AO8 A;  4ELH A;  3UM8 A;  2OIP A;  4PSS A;  3RG9 A;  1OHK A;  3S7A A;  1RA2 A;  2W3W A;  4LAE X;  1IA3 A;  6DFR A;  3SR5 X;  5DXV A;  1PD9 A;  5HT4 A;  3IRO A;  1DG7 A;  1RX2 A;  1DLS A;  2O7P A;  1RB2 A;  3FQZ A;  3JWF A;  3NRR A;  3SGY A;  3K45 A;  3D84 X;  3DL5 A;  4XEC X;  3M08 A;  3R33 A;  3NXV A;  1LUD A;  2QK8 A;  2INQ A;  5HSR A;  3NZD A;  3QG2 A;  3F0Q X;  1JOM A;  1U70 A;  3CSE A;  3QL3 A;  3GHV A;  3NTZ A;  3SAI A;  2BLC A;  2JYB A;  4EJ1 A;  3S9U A;  3NZB X;  3IA5 A;  3KJS A;  1S3U A;  4X5G A;  1LY3 A;  2D5N A;  3QLR A;  2W3B A;  5ECX A;  4HOF A;  5HVE A;  1DDR A;  3FQF A;  3SRS X;  4KAK A;  4DDR A;  3DRC A;  4KM2 A;  4KFJ A;  3E0B A;  3NZA X;  4RGC A;  3NXO A;  3IRN A;  2LF1 A;  2W9H A;  3DGA A;  3FL8 A;  3FYW X;  5HQY A;  5U27 A;  4ECK A;  1RX1 A;  3QYL A;  4OR7 A;  4H95 A;  1DYJ A;  1RA8 A;  3HJ3 A;  4HOG A;  3KGY A;  4XE6 X;  2CIG A;  1PD8 A;  3DG8 A;  1PDB A;  3FQC A;  3CL9 A;  4X5I A;  3FRE X;  3K2H A;  5HF2 X;  1JUV A;  1DIU A;  3LG4 A;  3JWK A;  3QLZ A;  4IXG X;  2BLB A;  1RE7 A;  3NZ9 X;  3FY9 X;  3KFY A;  2H2Q A;  4EIZ A;  5HPB A;  3M09 A;  4FGH A;  2W3V A;  2D0K A;  4M6L A;  4NX6 A;  5HT5 A;  1RH3 A;  4XT5 A;  1YHO A;  3S3V A;  3ZPC A;  3SRQ X;  1RX4 A;  1VJ3 A;  1AI9 A;  1M79 A;  3DFR A;  1RG7 A;  1DR4 A;  1DIS A;  1QZF A;  2HXV A;  4ELE A;  1LY4 A;  1DHJ A;  2GD9 A;  5U26 A;  2FZJ A;  4X5H A;  1CZ3 A;  3GI2 A;  4KJJ A;  5DFR A;  1M78 A;  3FYV X;  3Q1H A;  3QGT A;  4KNE A;  2ANO A;  4DPD A;  3DAT A;  3K47 A;  2L28 A;  4X5F A;  1IA1 A;  1S3V A;  4M7U A;  4I13 A;  1SEJ A;  3N0H A;  2W9G A;  1BZF A;  1DLR A;  4DP3 A;  1DRE A;  4QJC A;  1DDS A;  4QI9 A;  1VDR A;  2ANQ A;  2C2S A;  3EEM A;  5HVB A;  1DG5 A;  4M6J A;  1U71 A;  4KY8 A;  3UM6 A;  5HF0 X;  3INV A;  4P66 A;  4Q6A A;  3SRW X;  5JG0 X;  4FHB A;  4KEB A;  3QLS A;  2OBC A;  3F0X X;  4PTJ A;  1S3Y A;  3JVX A;  1RA9 A;  1DF7 A;  3FY8 X;  4DPH A;  2B3Z A;  5FDA A;  3QLW A;  4Q67 A;  4XT6 A;  3EIG A;  3QLX A;  4M7V A;  3F8Y A;  1DYH A;  4P68 A;  3KY8 A;  3IRM A;  3TQB A;  3L3R A;  1KMS A;  3SA2 A;  3JW3 A;  4PST A;  3EEL A;  4GH8 A;  4QHV A;  3QL0 A;  1M7A A;  3NXT A;  3FQV A;  4NX7 A; 
#chains in the Genus database with same CATH topology
 4DFR A;  1DRH A;  2DRC A;  1HFQ A;  4KL9 A;  1D1G A;  3IA4 A;  1DG8 A;  4QLG A;  1OHJ A;  2AZN A;  5EAJ A;  3RO9 A;  3OAF A;  3FRA X;  3NZC X;  1BOZ A;  1AOE A;  3UM5 A;  1RX9 A;  1KLK A;  3F0B X;  3K74 A;  1DR2 A;  4P3Q A;  2ITH A;  5HUI A;  4QLE A;  3F0V X;  5CCC A;  4G3M A;  1E26 A;  1RX5 A;  3GHW A;  4G95 A;  4KYA A;  5ECC A;  3F8Z A;  4LEK X;  3FRF X;  4Q0D A;  3CLB A;  1DR5 A;  3SH2 A;  3SQY X;  5HQZ A;  3NXR A;  3DL6 A;  4HA9 A;  1DAJ A;  7DFR A;  2G6V A;  4EIG A;  3JTW A;  4I1N A;  2BLA A;  4M2X A;  4LAG X;  4FGG A;  4KD7 A;  3FRD X;  3GHC A;  1RX6 A;  1J3J A;  3IX9 A;  2W3A A;  8DFR A;  2HQP A;  1RF7 A;  1MVT A;  4M6K A;  1RC4 A;  4HA7 A;  3EX8 A;  1DRB A;  3NZ6 X;  4KBN A;  2XW7 A;  3ROA A;  1J3K A;  3EEJ A;  3TQ8 A;  2W3M A;  4PSY A;  3TD8 A;  3GYF A;  3CD2 A;  3F0U X;  3F0S X;  3NXX A;  4QJZ D;  5E8Q A;  4XT8 A;  4HOE A;  4H96 A;  4IXE D;  3SA1 A;  3FQ0 A;  1RD7 A;  3HBB A;  1KMV A;  3FQO A;  4ELG A;  4ELB A;  3JWC A;  4P3R A;  4X5J A;  3SRU X;  3NXY A;  3VCO A;  3ZPG A;  4KJK A;  4XRB A;  3I8A X;  3DAU A;  2W9S A;  3QYO A;  3JWM A;  2W9T A;  4QLF A;  1DRF A;  4Q0E A;  1HFR A;  1RB3 A;  3TQ9 A;  3NU0 A;  4KM0 A;  3FL9 A;  1IA4 A;  3QLY A;  1CD2 A;  3JSU A;  2CD2 A;  3TQA A;  1IA2 A;  1RX8 A;  4PDJ A;  4EIL A;  1DYI A;  2FZI A;  1DR3 A;  5HSU A;  1DHF A;  4H97 A;  1DR6 A;  4XT4 A;  1RX3 A;  3OCH A;  2BL9 A;  1HFP A;  4TU5 X;  4LAH X;  1S3W A;  5JA3 A;  2HM9 A;  5CC9 A;  2KGK A;  2FZH A;  4OSG A;  4G8Z X;  3EEK A;  4H98 A;  3D80 A;  4PTH A;  1TDR A;  1MVS A;  2DHF A;  3F91 A;  5HI6 A;  1JOL A;  3FS6 A;  1ZDR A;  1RA1 A;  2ZZA A;  4KLX A;  1DR1 A;  4ELF A;  1U72 A;  3FRB X;  4CD2 A;  3KJR A;  4KJL A;  1J3I A;  2C2T A;  3SRR X;  3I3R A;  3JW5 A;  4KY4 A;  4XT7 A;  1RX7 A;  1RA3 A;  4IXF X;  1DHI A;  2P4G A;  1DRA A;  3QFX A;  1DYR A;  1DR7 A;  1AO8 A;  4ELH A;  3UM8 A;  2OIP A;  4PSS A;  3RG9 A;  1OHK A;  3S7A A;  1RA2 A;  2W3W A;  4LAE X;  1IA3 A;  6DFR A;  3SR5 X;  5DXV A;  1PD9 A;  5HT4 A;  3IRO A;  1DG7 A;  1RX2 A;  1DLS A;  2O7P A;  1RB2 A;  3FQZ A;  3JWF A;  3NRR A;  3SGY A;  3K45 A;  3D84 X;  3DL5 A;  4XEC X;  3M08 A;  3R33 A;  3NXV A;  1LUD A;  2QK8 A;  2INQ A;  5HSR A;  3NZD A;  3QG2 A;  3F0Q X;  1JOM A;  1U70 A;  3CSE A;  3QL3 A;  3GHV A;  3NTZ A;  3SAI A;  2BLC A;  2JYB A;  4EJ1 A;  3S9U A;  3NZB X;  3IA5 A;  3KJS A;  1S3U A;  4X5G A;  1LY3 A;  2D5N A;  3QLR A;  2W3B A;  5ECX A;  4HOF A;  5HVE A;  1DDR A;  3FQF A;  3SRS X;  4KAK A;  4DDR A;  3DRC A;  4KM2 A;  4KFJ A;  3E0B A;  3NZA X;  4RGC A;  3NXO A;  3IRN A;  2LF1 A;  2W9H A;  3DGA A;  3FL8 A;  3FYW X;  5HQY A;  5U27 A;  4ECK A;  1RX1 A;  3QYL A;  4OR7 A;  4H95 A;  1DYJ A;  1RA8 A;  3HJ3 A;  4HOG A;  3KGY A;  4XE6 X;  2CIG A;  1PD8 A;  3DG8 A;  1PDB A;  3FQC A;  3CL9 A;  4X5I A;  3FRE X;  3K2H A;  5HF2 X;  1JUV A;  1DIU A;  3LG4 A;  3JWK A;  3QLZ A;  4IXG X;  2BLB A;  1RE7 A;  3NZ9 X;  3FY9 X;  3KFY A;  2H2Q A;  4EIZ A;  5HPB A;  3M09 A;  4FGH A;  2W3V A;  2D0K A;  4M6L A;  4NX6 A;  5HT5 A;  1RH3 A;  4XT5 A;  1YHO A;  3S3V A;  3ZPC A;  3SRQ X;  1RX4 A;  1VJ3 A;  1AI9 A;  1M79 A;  3DFR A;  1RG7 A;  1DR4 A;  1DIS A;  1QZF A;  2HXV A;  4ELE A;  1LY4 A;  1DHJ A;  2GD9 A;  5U26 A;  2FZJ A;  4X5H A;  1CZ3 A;  3GI2 A;  4KJJ A;  5DFR A;  1M78 A;  3FYV X;  3Q1H A;  3QGT A;  4KNE A;  2ANO A;  4DPD A;  3DAT A;  3K47 A;  2L28 A;  4X5F A;  1IA1 A;  1S3V A;  4M7U A;  4I13 A;  1SEJ A;  3N0H A;  2W9G A;  1BZF A;  1DLR A;  4DP3 A;  1DRE A;  4QJC A;  1DDS A;  4QI9 A;  1VDR A;  2ANQ A;  2C2S A;  3EEM A;  5HVB A;  1DG5 A;  4M6J A;  1U71 A;  4KY8 A;  3UM6 A;  5HF0 X;  3INV A;  4P66 A;  4Q6A A;  3SRW X;  5JG0 X;  4FHB A;  4KEB A;  3QLS A;  2OBC A;  3F0X X;  4PTJ A;  1S3Y A;  3JVX A;  1RA9 A;  1DF7 A;  3FY8 X;  4DPH A;  2B3Z A;  5FDA A;  3QLW A;  4Q67 A;  4XT6 A;  3EIG A;  3QLX A;  4M7V A;  3F8Y A;  1DYH A;  4P68 A;  3KY8 A;  3IRM A;  3TQB A;  3L3R A;  1KMS A;  3SA2 A;  3JW3 A;  4PST A;  3EEL A;  4GH8 A;  4QHV A;  3QL0 A;  1M7A A;  3NXT A;  3FQV A;  4NX7 A; 
#chains in the Genus database with same CATH homology
 4DFR A;  1DRH A;  2DRC A;  1HFQ A;  4KL9 A;  1D1G A;  3IA4 A;  1DG8 A;  4QLG A;  1OHJ A;  2AZN A;  5EAJ A;  3RO9 A;  3OAF A;  3FRA X;  3NZC X;  1BOZ A;  1AOE A;  3UM5 A;  1RX9 A;  1KLK A;  3F0B X;  3K74 A;  1DR2 A;  4P3Q A;  2ITH A;  5HUI A;  4QLE A;  3F0V X;  5CCC A;  4G3M A;  1E26 A;  1RX5 A;  3GHW A;  4G95 A;  4KYA A;  5ECC A;  3F8Z A;  4LEK X;  3FRF X;  4Q0D A;  3CLB A;  1DR5 A;  3SH2 A;  3SQY X;  5HQZ A;  3NXR A;  3DL6 A;  4HA9 A;  1DAJ A;  7DFR A;  2G6V A;  4EIG A;  3JTW A;  4I1N A;  2BLA A;  4M2X A;  4LAG X;  4FGG A;  4KD7 A;  3FRD X;  3GHC A;  1RX6 A;  1J3J A;  3IX9 A;  2W3A A;  8DFR A;  2HQP A;  1RF7 A;  1MVT A;  4M6K A;  1RC4 A;  4HA7 A;  3EX8 A;  1DRB A;  3NZ6 X;  4KBN A;  2XW7 A;  3ROA A;  1J3K A;  3EEJ A;  3TQ8 A;  2W3M A;  4PSY A;  3TD8 A;  3GYF A;  3CD2 A;  3F0U X;  3F0S X;  3NXX A;  4QJZ D;  5E8Q A;  4XT8 A;  4HOE A;  4H96 A;  4IXE D;  3SA1 A;  3FQ0 A;  1RD7 A;  3HBB A;  1KMV A;  3FQO A;  4ELG A;  4ELB A;  3JWC A;  4P3R A;  4X5J A;  3SRU X;  3NXY A;  3VCO A;  3ZPG A;  4KJK A;  4XRB A;  3I8A X;  3DAU A;  2W9S A;  3QYO A;  3JWM A;  2W9T A;  4QLF A;  1DRF A;  4Q0E A;  1HFR A;  1RB3 A;  3TQ9 A;  3NU0 A;  4KM0 A;  3FL9 A;  1IA4 A;  3QLY A;  1CD2 A;  3JSU A;  2CD2 A;  3TQA A;  1IA2 A;  1RX8 A;  4PDJ A;  4EIL A;  1DYI A;  2FZI A;  1DR3 A;  5HSU A;  1DHF A;  4H97 A;  1DR6 A;  4XT4 A;  1RX3 A;  3OCH A;  2BL9 A;  1HFP A;  4TU5 X;  4LAH X;  1S3W A;  5JA3 A;  2HM9 A;  5CC9 A;  2KGK A;  2FZH A;  4OSG A;  4G8Z X;  3EEK A;  4H98 A;  3D80 A;  4PTH A;  1TDR A;  1MVS A;  2DHF A;  3F91 A;  5HI6 A;  1JOL A;  3FS6 A;  1ZDR A;  1RA1 A;  2ZZA A;  4KLX A;  1DR1 A;  4ELF A;  1U72 A;  3FRB X;  4CD2 A;  3KJR A;  4KJL A;  1J3I A;  2C2T A;  3SRR X;  3I3R A;  3JW5 A;  4KY4 A;  4XT7 A;  1RX7 A;  1RA3 A;  4IXF X;  1DHI A;  2P4G A;  1DRA A;  3QFX A;  1DYR A;  1DR7 A;  1AO8 A;  4ELH A;  3UM8 A;  2OIP A;  4PSS A;  3RG9 A;  1OHK A;  3S7A A;  1RA2 A;  2W3W A;  4LAE X;  1IA3 A;  6DFR A;  3SR5 X;  5DXV A;  1PD9 A;  5HT4 A;  3IRO A;  1DG7 A;  1RX2 A;  1DLS A;  2O7P A;  1RB2 A;  3FQZ A;  3JWF A;  3NRR A;  3SGY A;  3K45 A;  3D84 X;  3DL5 A;  4XEC X;  3M08 A;  3R33 A;  3NXV A;  1LUD A;  2QK8 A;  2INQ A;  5HSR A;  3NZD A;  3QG2 A;  3F0Q X;  1JOM A;  1U70 A;  3CSE A;  3QL3 A;  3GHV A;  3NTZ A;  3SAI A;  2BLC A;  2JYB A;  4EJ1 A;  3S9U A;  3NZB X;  3IA5 A;  3KJS A;  1S3U A;  4X5G A;  1LY3 A;  2D5N A;  3QLR A;  2W3B A;  5ECX A;  4HOF A;  5HVE A;  1DDR A;  3FQF A;  3SRS X;  4KAK A;  4DDR A;  3DRC A;  4KM2 A;  4KFJ A;  3E0B A;  3NZA X;  4RGC A;  3NXO A;  3IRN A;  2LF1 A;  2W9H A;  3DGA A;  3FL8 A;  3FYW X;  5HQY A;  5U27 A;  4ECK A;  1RX1 A;  3QYL A;  4OR7 A;  4H95 A;  1DYJ A;  1RA8 A;  3HJ3 A;  4HOG A;  3KGY A;  4XE6 X;  2CIG A;  1PD8 A;  3DG8 A;  1PDB A;  3FQC A;  3CL9 A;  4X5I A;  3FRE X;  3K2H A;  5HF2 X;  1JUV A;  1DIU A;  3LG4 A;  3JWK A;  3QLZ A;  4IXG X;  2BLB A;  1RE7 A;  3NZ9 X;  3FY9 X;  3KFY A;  2H2Q A;  4EIZ A;  5HPB A;  3M09 A;  4FGH A;  2W3V A;  2D0K A;  4M6L A;  4NX6 A;  5HT5 A;  1RH3 A;  4XT5 A;  1YHO A;  3S3V A;  3ZPC A;  3SRQ X;  1RX4 A;  1VJ3 A;  1AI9 A;  1M79 A;  3DFR A;  1RG7 A;  1DR4 A;  1DIS A;  1QZF A;  2HXV A;  4ELE A;  1LY4 A;  1DHJ A;  2GD9 A;  5U26 A;  2FZJ A;  4X5H A;  1CZ3 A;  3GI2 A;  4KJJ A;  5DFR A;  1M78 A;  3FYV X;  3Q1H A;  3QGT A;  4KNE A;  2ANO A;  4DPD A;  3DAT A;  3K47 A;  2L28 A;  4X5F A;  1IA1 A;  1S3V A;  4M7U A;  4I13 A;  1SEJ A;  3N0H A;  2W9G A;  1BZF A;  1DLR A;  4DP3 A;  1DRE A;  4QJC A;  1DDS A;  4QI9 A;  1VDR A;  2ANQ A;  2C2S A;  3EEM A;  5HVB A;  1DG5 A;  4M6J A;  1U71 A;  4KY8 A;  3UM6 A;  5HF0 X;  3INV A;  4P66 A;  4Q6A A;  3SRW X;  5JG0 X;  4FHB A;  4KEB A;  3QLS A;  2OBC A;  3F0X X;  4PTJ A;  1S3Y A;  3JVX A;  1RA9 A;  1DF7 A;  3FY8 X;  4DPH A;  2B3Z A;  5FDA A;  3QLW A;  4Q67 A;  4XT6 A;  3EIG A;  3QLX A;  4M7V A;  3F8Y A;  1DYH A;  4P68 A;  3KY8 A;  3IRM A;  3TQB A;  3L3R A;  1KMS A;  3SA2 A;  3JW3 A;  4PST A;  3EEL A;  4GH8 A;  4QHV A;  3QL0 A;  1M7A A;  3NXT A;  3FQV A;  4NX7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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