3GHCA

Design, synthesis, and x-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agenst
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFSRMTTTSSVEGKQNLVIMGKKTWFSIPEKSRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 55
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3ghcA00
3K74A 4DPHA 4M7VA 1DISA 1PDBA 3NZBX 1VJ3A 3QLXA 1BZFA 5U27A 5HUIA 1DG8A 5HI6A 1KMVA 2B3ZA 1MVTA 5DXVA 4KY4A 3SRUX 3QFXA 1DLRA 5HSUA 4KD7A 1RX8A 4DFRA 3S3VA 3GHCA 3DFRA 1DYIA 1MVSA 3L3RA 3NXOA 3SRQX 1J3IA 1S3WA 3ROAA 3DL6A 5HF0X 3TD8A 4H96A 3E0BA 1DLSA 3F0SX 4HOGA 4NX6A 1RA8A 3NRRA 2W9HA 5E8QA 4M2XA 7DFRA 1RX6A 2BL9A 4QLEA 5JG0X 1DRAA 3FRBX 2H2QA 1DR6A 4M6JA 3SGYA 3FQFA 4M6LA 1DHJA 4ELBA 4KLXA 3RO9A 4M7UA 1IA4A 1RA9A 2C2TA 4IXGX 1DREA 2KGKA 4X5IA 3I8AX 3KY8A 4NX7A 2FZHA 1RF7A 3NZDA 4P66A 3FRAX 1RG7A 4KJLA 4EJ1A 1CZ3A 4TU5X 1M78A 3QLYA 3CSEA 1LUDA 1VDRA 3IA4A 4HOEA 4PDJA 5JA3A 3HJ3A 3NU0A 4KYAA 3SRRX 4XRBA 1LY4A 4ELFA 3SA2A 1JOLA 5HVEA 3QGTA 2INQA 3SQYX 4XT7A 3NXTA 4XECX 4KNEA 1U71A 2XW7A 3CD2A 4GH8A 2ITHA 1DYHA 4G95A 3JSUA 2W9TA 5HVBA 4FGHA 3UM5A 2ANOA 3KJRA 4Q6AA 1RX2A 2W9GA 1RE7A 4Q67A 1J3JA 3QG2A 5HQYA 3ZPCA 4Q0DA 2JYBA 3TQ9A 1HFRA 2BLCA 3SRWX 2QK8A 1IA3A 4M6KA 4EILA 1DAJA 1RX3A 3EELA 5ECCA 2CD2A 3FL9A 3I3RA 3NXVA 5ECXA 1OHJA 3OCHA 4EIGA 3FYVX 3DL5A 4KY8A 3K2HA 4PSYA 3JWCA 4QI9A 2BLBA 3NXRA 8DFRA 3F0UX 4KBNA 3DGAA 3F8YA 5U26A 4KM0A 1DRFA 3RG9A 3F8ZA 5HPBA 1RX9A 5CC9A 2DHFA 3TQ8A 1DR7A 1DRHA 4XT8A 1PD9A 3FQ0A 3EEJA 3QLZA 1DG7A 3NZCX 4ELEA 2W3MA 3NXYA 3JWFA 1ZDRA 4FGGA 2W3BA 3NZAX 3SR5X 3FS6A 1JOMA 3EX8A 5HT4A 2OIPA 4PSSA 1DR5A 4KM2A 3IX9A 3F0QX 4EIZA 3JW3A 1DF7A 3FY8X 4P3QA 1KMSA 2D0KA 3FQVA 1RD7A 4HA9A 4KL9A 3KFYA 4ELHA 4DDRA 1RB3A 3FL8A 1RH3A 4KJKA 3F91A 1OHKA 3FRFX 1DIUA 3QLSA 3NXXA 3FRDX 3IRMA 3QYOA 3OAFA 3QLWA 4X5FA 2ZZAA 1AO8A 1D1GA 5HT5A 4H95A 2W3AA 5HQZA 1RA1A 3GI2A 1J3KA 1SEJA 4OR7A 1RX7A 4X5JA 3NZ9X 4G3MA 4DPDA 1DDSA 1JUVA 3JTWA 3KGYA 1DDRA 3F0VX 4RGCA 2W9SA 3Q1HA 1HFQA 3F0XX 2BLAA 3INVA 4KAKA 1BOZA 1E26A 1DR3A 3TQBA 4CD2A 3N0HA 3KJSA 4XT4A 4ECKA 4H98A 1DG5A 3M09A 4X5HA 2HM9A 1PD8A 1RX5A 1DRBA 1QZFA 4OSGA 2C2SA 4I1NA 1RX1A 4HA7A 4QHVA 2D5NA 3QLRA 4PSTA 3NTZA 3S9UA 3JWMA 3TQAA 3NZ6X 3EIGA 4IXED 4XE6X 1KLKA 2FZIA 1DYRA 4KEBA 3HBBA 3LG4A 4QJCA 3QL3A 1TDRA 4PTJA 4G8ZX 3UM6A 2O7PA 1RC4A 1RA3A 1IA2A 1S3UA 4LAEX 3QL0A 1RA2A 3FQZA 1DYJA 4PTHA 2AZNA 3GHVA 1AI9A 1U72A 6DFRA 1DR4A 1DHFA 2W3WA 3FYWX 3IROA 3IA5A 4FHBA 3QYLA 3SAIA 4LAGX 1M79A 2HQPA 2OBCA 3JW5A 2G6VA 3JWKA 3CLBA 3CL9A 3GHWA 3FREX 4XT5A 4XT6A 3DRCA 3FY9X 3D80A 2CIGA 4Q0EA 1LY3A 3EEKA 1RX4A 2L28A 1YHOA 5HSRA 3IRNA 3M08A 3FQOA 2LF1A 4ELGA 3DAUA 3S7AA 4P68A 4IXFX 2DRCA 3JVXA 4LEKX 3D84X 4QJZD 3K45A 4QLFA 2FZJA 3EEMA 1U70A 5EAJA 2HXVA 4KJJA 1S3YA 3R33A 3SA1A 1HFPA 2P4GA 4HOFA 1AOEA 5FDAA 3VCOA 4P3RA 3ZPGA 2ANQA 3UM8A 5HF2X 1M7AA 4LAHX 3K47A 3SH2A 1DR2A 5DFRA 3F0BX 3DATA 2GD9A 4DP3A 4KFJA 4H97A 3SRSX 1RB2A 4I13A 3GYFA 1DR1A 1CD2A 3FQCA 1DHIA 1S3VA 1IA1A 5CCCA 3DG8A 2W3VA 4QLGA 4X5GA
chains in the Genus database with same CATH superfamily
3K74A 4DPHA 4M7VA 1DISA 1PDBA 3NZBX 1VJ3A 3QLXA 1BZFA 5U27A 5HUIA 1DG8A 5HI6A 1KMVA 2B3ZA 1MVTA 5DXVA 4KY4A 3SRUX 3QFXA 1DLRA 5HSUA 4KD7A 1RX8A 4DFRA 3S3VA 3GHCA 3DFRA 1DYIA 1MVSA 3L3RA 3NXOA 3SRQX 1J3IA 1S3WA 3ROAA 3DL6A 5HF0X 3TD8A 4H96A 3E0BA 1DLSA 3F0SX 4HOGA 4NX6A 1RA8A 3NRRA 2W9HA 5E8QA 4M2XA 7DFRA 1RX6A 2BL9A 4QLEA 5JG0X 1DRAA 3FRBX 2H2QA 1DR6A 4M6JA 3SGYA 3FQFA 4M6LA 1DHJA 4ELBA 4KLXA 3RO9A 4M7UA 1IA4A 1RA9A 2C2TA 4IXGX 1DREA 2KGKA 4X5IA 3I8AX 3KY8A 4NX7A 2FZHA 1RF7A 3NZDA 4P66A 3FRAX 1RG7A 4KJLA 4EJ1A 1CZ3A 4TU5X 1M78A 3QLYA 3CSEA 1LUDA 1VDRA 3IA4A 4HOEA 4PDJA 5JA3A 3HJ3A 3NU0A 4KYAA 3SRRX 4XRBA 1LY4A 4ELFA 3SA2A 1JOLA 5HVEA 3QGTA 2INQA 3SQYX 4XT7A 3NXTA 4XECX 4KNEA 1U71A 2XW7A 3CD2A 4GH8A 2ITHA 1DYHA 4G95A 3JSUA 2W9TA 5HVBA 4FGHA 3UM5A 2ANOA 3KJRA 4Q6AA 1RX2A 2W9GA 1RE7A 4Q67A 1J3JA 3QG2A 5HQYA 3ZPCA 4Q0DA 2JYBA 3TQ9A 1HFRA 2BLCA 3SRWX 2QK8A 1IA3A 4M6KA 4EILA 1DAJA 1RX3A 3EELA 5ECCA 2CD2A 3FL9A 3I3RA 3NXVA 5ECXA 1OHJA 3OCHA 4EIGA 3FYVX 3DL5A 4KY8A 3K2HA 4PSYA 3JWCA 4QI9A 2BLBA 3NXRA 8DFRA 3F0UX 4KBNA 3DGAA 3F8YA 5U26A 4KM0A 1DRFA 3RG9A 3F8ZA 5HPBA 1RX9A 5CC9A 2DHFA 3TQ8A 1DR7A 1DRHA 4XT8A 1PD9A 3FQ0A 3EEJA 3QLZA 1DG7A 3NZCX 4ELEA 2W3MA 3NXYA 3JWFA 1ZDRA 4FGGA 2W3BA 3NZAX 3SR5X 3FS6A 1JOMA 3EX8A 5HT4A 2OIPA 4PSSA 1DR5A 4KM2A 3IX9A 3F0QX 4EIZA 3JW3A 1DF7A 3FY8X 4P3QA 1KMSA 2D0KA 3FQVA 1RD7A 4HA9A 4KL9A 3KFYA 4ELHA 4DDRA 1RB3A 3FL8A 1RH3A 4KJKA 3F91A 1OHKA 3FRFX 1DIUA 3QLSA 3NXXA 3FRDX 3IRMA 3QYOA 3OAFA 3QLWA 4X5FA 2ZZAA 1AO8A 1D1GA 5HT5A 4H95A 2W3AA 5HQZA 1RA1A 3GI2A 1J3KA 1SEJA 4OR7A 1RX7A 4X5JA 3NZ9X 4G3MA 4DPDA 1DDSA 1JUVA 3JTWA 3KGYA 1DDRA 3F0VX 4RGCA 2W9SA 3Q1HA 1HFQA 3F0XX 2BLAA 3INVA 4KAKA 1BOZA 1E26A 1DR3A 3TQBA 4CD2A 3N0HA 3KJSA 4XT4A 4ECKA 4H98A 1DG5A 3M09A 4X5HA 2HM9A 1PD8A 1RX5A 1DRBA 1QZFA 4OSGA 2C2SA 4I1NA 1RX1A 4HA7A 4QHVA 2D5NA 3QLRA 4PSTA 3NTZA 3S9UA 3JWMA 3TQAA 3NZ6X 3EIGA 4IXED 4XE6X 1KLKA 2FZIA 1DYRA 4KEBA 3HBBA 3LG4A 4QJCA 3QL3A 1TDRA 4PTJA 4G8ZX 3UM6A 2O7PA 1RC4A 1RA3A 1IA2A 1S3UA 4LAEX 3QL0A 1RA2A 3FQZA 1DYJA 4PTHA 2AZNA 3GHVA 1AI9A 1U72A 6DFRA 1DR4A 1DHFA 2W3WA 3FYWX 3IROA 3IA5A 4FHBA 3QYLA 3SAIA 4LAGX 1M79A 2HQPA 2OBCA 3JW5A 2G6VA 3JWKA 3CLBA 3CL9A 3GHWA 3FREX 4XT5A 4XT6A 3DRCA 3FY9X 3D80A 2CIGA 4Q0EA 1LY3A 3EEKA 1RX4A 2L28A 1YHOA 5HSRA 3IRNA 3M08A 3FQOA 2LF1A 4ELGA 3DAUA 3S7AA 4P68A 4IXFX 2DRCA 3JVXA 4LEKX 3D84X 4QJZD 3K45A 4QLFA 2FZJA 3EEMA 1U70A 5EAJA 2HXVA 4KJJA 1S3YA 3R33A 3SA1A 1HFPA 2P4GA 4HOFA 1AOEA 5FDAA 3VCOA 4P3RA 3ZPGA 2ANQA 3UM8A 5HF2X 1M7AA 4LAHX 3K47A 3SH2A 1DR2A 5DFRA 3F0BX 3DATA 2GD9A 4DP3A 4KFJA 4H97A 3SRSX 1RB2A 4I13A 3GYFA 1DR1A 1CD2A 3FQCA 1DHIA 1S3VA 1IA1A 5CCCA 3DG8A 2W3VA 4QLGA 4X5GA
chains in the Genus database with same CATH topology
3K74A 4DPHA 4M7VA 1DISA 1PDBA 3NZBX 1VJ3A 3QLXA 1BZFA 5U27A 5HUIA 1DG8A 5HI6A 1KMVA 2B3ZA 1MVTA 5DXVA 4KY4A 3SRUX 3QFXA 1DLRA 5HSUA 4KD7A 1RX8A 4DFRA 3S3VA 3GHCA 3DFRA 1DYIA 1MVSA 3L3RA 3NXOA 3SRQX 1J3IA 1S3WA 3ROAA 3DL6A 5HF0X 3TD8A 4H96A 3E0BA 1DLSA 3F0SX 4HOGA 4NX6A 1RA8A 3NRRA 2W9HA 5E8QA 4M2XA 7DFRA 1RX6A 2BL9A 4QLEA 5JG0X 1DRAA 3FRBX 2H2QA 1DR6A 4M6JA 3SGYA 3FQFA 4M6LA 1DHJA 4ELBA 4KLXA 3RO9A 4M7UA 1IA4A 1RA9A 2C2TA 4IXGX 1DREA 2KGKA 4X5IA 3I8AX 3KY8A 4NX7A 2FZHA 1RF7A 3NZDA 4P66A 3FRAX 1RG7A 4KJLA 4EJ1A 1CZ3A 4TU5X 1M78A 3QLYA 3CSEA 1LUDA 1VDRA 3IA4A 4HOEA 4PDJA 5JA3A 3HJ3A 3NU0A 4KYAA 3SRRX 4XRBA 1LY4A 4ELFA 3SA2A 1JOLA 5HVEA 3QGTA 2INQA 3SQYX 4XT7A 3NXTA 4XECX 4KNEA 1U71A 2XW7A 3CD2A 4GH8A 2ITHA 1DYHA 4G95A 3JSUA 2W9TA 5HVBA 4FGHA 3UM5A 2ANOA 3KJRA 4Q6AA 1RX2A 2W9GA 1RE7A 4Q67A 1J3JA 3QG2A 5HQYA 3ZPCA 4Q0DA 2JYBA 3TQ9A 1HFRA 2BLCA 3SRWX 2QK8A 1IA3A 4M6KA 4EILA 1DAJA 1RX3A 3EELA 5ECCA 2CD2A 3FL9A 3I3RA 3NXVA 5ECXA 1OHJA 3OCHA 4EIGA 3FYVX 3DL5A 4KY8A 3K2HA 4PSYA 3JWCA 4QI9A 2BLBA 3NXRA 8DFRA 3F0UX 4KBNA 3DGAA 3F8YA 5U26A 4KM0A 1DRFA 3RG9A 3F8ZA 5HPBA 1RX9A 5CC9A 2DHFA 3TQ8A 1DR7A 1DRHA 4XT8A 1PD9A 3FQ0A 3EEJA 3QLZA 1DG7A 3NZCX 4ELEA 2W3MA 3NXYA 3JWFA 1ZDRA 4FGGA 2W3BA 3NZAX 3SR5X 3FS6A 1JOMA 3EX8A 5HT4A 2OIPA 4PSSA 1DR5A 4KM2A 3IX9A 3F0QX 4EIZA 3JW3A 1DF7A 3FY8X 4P3QA 1KMSA 2D0KA 3FQVA 1RD7A 4HA9A 4KL9A 3KFYA 4ELHA 4DDRA 1RB3A 3FL8A 1RH3A 4KJKA 3F91A 1OHKA 3FRFX 1DIUA 3QLSA 3NXXA 3FRDX 3IRMA 3QYOA 3OAFA 3QLWA 4X5FA 2ZZAA 1AO8A 1D1GA 5HT5A 4H95A 2W3AA 5HQZA 1RA1A 3GI2A 1J3KA 1SEJA 4OR7A 1RX7A 4X5JA 3NZ9X 4G3MA 4DPDA 1DDSA 1JUVA 3JTWA 3KGYA 1DDRA 3F0VX 4RGCA 2W9SA 3Q1HA 1HFQA 3F0XX 2BLAA 3INVA 4KAKA 1BOZA 1E26A 1DR3A 3TQBA 4CD2A 3N0HA 3KJSA 4XT4A 4ECKA 4H98A 1DG5A 3M09A 4X5HA 2HM9A 1PD8A 1RX5A 1DRBA 1QZFA 4OSGA 2C2SA 4I1NA 1RX1A 4HA7A 4QHVA 2D5NA 3QLRA 4PSTA 3NTZA 3S9UA 3JWMA 3TQAA 3NZ6X 3EIGA 4IXED 4XE6X 1KLKA 2FZIA 1DYRA 4KEBA 3HBBA 3LG4A 4QJCA 3QL3A 1TDRA 4PTJA 4G8ZX 3UM6A 2O7PA 1RC4A 1RA3A 1IA2A 1S3UA 4LAEX 3QL0A 1RA2A 3FQZA 1DYJA 4PTHA 2AZNA 3GHVA 1AI9A 1U72A 6DFRA 1DR4A 1DHFA 2W3WA 3FYWX 3IROA 3IA5A 4FHBA 3QYLA 3SAIA 4LAGX 1M79A 2HQPA 2OBCA 3JW5A 2G6VA 3JWKA 3CLBA 3CL9A 3GHWA 3FREX 4XT5A 4XT6A 3DRCA 3FY9X 3D80A 2CIGA 4Q0EA 1LY3A 3EEKA 1RX4A 2L28A 1YHOA 5HSRA 3IRNA 3M08A 3FQOA 2LF1A 4ELGA 3DAUA 3S7AA 4P68A 4IXFX 2DRCA 3JVXA 4LEKX 3D84X 4QJZD 3K45A 4QLFA 2FZJA 3EEMA 1U70A 5EAJA 2HXVA 4KJJA 1S3YA 3R33A 3SA1A 1HFPA 2P4GA 4HOFA 1AOEA 5FDAA 3VCOA 4P3RA 3ZPGA 2ANQA 3UM8A 5HF2X 1M7AA 4LAHX 3K47A 3SH2A 1DR2A 5DFRA 3F0BX 3DATA 2GD9A 4DP3A 4KFJA 4H97A 3SRSX 1RB2A 4I13A 3GYFA 1DR1A 1CD2A 3FQCA 1DHIA 1S3VA 1IA1A 5CCCA 3DG8A 2W3VA 4QLGA 4X5GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3K74 A;  4DPH A;  4M7V A;  1DIS A;  1PDB A;  3NZB X;  1VJ3 A;  3QLX A;  1BZF A;  5U27 A;  5HUI A;  1DG8 A;  5HI6 A;  1KMV A;  2B3Z A;  1MVT A;  5DXV A;  4KY4 A;  3SRU X;  3QFX A;  1DLR A;  5HSU A;  4KD7 A;  1RX8 A;  4DFR A;  3S3V A;  3GHC A;  3DFR A;  1DYI A;  1MVS A;  3L3R A;  3NXO A;  3SRQ X;  1J3I A;  1S3W A;  3ROA A;  3DL6 A;  5HF0 X;  3TD8 A;  4H96 A;  3E0B A;  1DLS A;  3F0S X;  4HOG A;  4NX6 A;  1RA8 A;  3NRR A;  2W9H A;  5E8Q A;  4M2X A;  7DFR A;  1RX6 A;  2BL9 A;  4QLE A;  5JG0 X;  1DRA A;  3FRB X;  2H2Q A;  1DR6 A;  4M6J A;  3SGY A;  3FQF A;  4M6L A;  1DHJ A;  4ELB A;  4KLX A;  3RO9 A;  4M7U A;  1IA4 A;  1RA9 A;  2C2T A;  4IXG X;  1DRE A;  2KGK A;  4X5I A;  3I8A X;  3KY8 A;  4NX7 A;  2FZH A;  1RF7 A;  3NZD A;  4P66 A;  3FRA X;  1RG7 A;  4KJL A;  4EJ1 A;  1CZ3 A;  4TU5 X;  1M78 A;  3QLY A;  3CSE A;  1LUD A;  1VDR A;  3IA4 A;  4HOE A;  4PDJ A;  5JA3 A;  3HJ3 A;  3NU0 A;  4KYA A;  3SRR X;  4XRB A;  1LY4 A;  4ELF A;  3SA2 A;  1JOL A;  5HVE A;  3QGT A;  2INQ A;  3SQY X;  4XT7 A;  3NXT A;  4XEC X;  4KNE A;  1U71 A;  2XW7 A;  3CD2 A;  4GH8 A;  2ITH A;  1DYH A;  4G95 A;  3JSU A;  2W9T A;  5HVB A;  4FGH A;  3UM5 A;  2ANO A;  3KJR A;  4Q6A A;  1RX2 A;  2W9G A;  1RE7 A;  4Q67 A;  1J3J A;  3QG2 A;  5HQY A;  3ZPC A;  4Q0D A;  2JYB A;  3TQ9 A;  1HFR A;  2BLC A;  3SRW X;  2QK8 A;  1IA3 A;  4M6K A;  4EIL A;  1DAJ A;  1RX3 A;  3EEL A;  5ECC A;  2CD2 A;  3FL9 A;  3I3R A;  3NXV A;  5ECX A;  1OHJ A;  3OCH A;  4EIG A;  3FYV X;  3DL5 A;  4KY8 A;  3K2H A;  4PSY A;  3JWC A;  4QI9 A;  2BLB A;  3NXR A;  8DFR A;  3F0U X;  4KBN A;  3DGA A;  3F8Y A;  5U26 A;  4KM0 A;  1DRF A;  3RG9 A;  3F8Z A;  5HPB A;  1RX9 A;  5CC9 A;  2DHF A;  3TQ8 A;  1DR7 A;  1DRH A;  4XT8 A;  1PD9 A;  3FQ0 A;  3EEJ A;  3QLZ A;  1DG7 A;  3NZC X;  4ELE A;  2W3M A;  3NXY A;  3JWF A;  1ZDR A;  4FGG A;  2W3B A;  3NZA X;  3SR5 X;  3FS6 A;  1JOM A;  3EX8 A;  5HT4 A;  2OIP A;  4PSS A;  1DR5 A;  4KM2 A;  3IX9 A;  3F0Q X;  4EIZ A;  3JW3 A;  1DF7 A;  3FY8 X;  4P3Q A;  1KMS A;  2D0K A;  3FQV A;  1RD7 A;  4HA9 A;  4KL9 A;  3KFY A;  4ELH A;  4DDR A;  1RB3 A;  3FL8 A;  1RH3 A;  4KJK A;  3F91 A;  1OHK A;  3FRF X;  1DIU A;  3QLS A;  3NXX A;  3FRD X;  3IRM A;  3QYO A;  3OAF A;  3QLW A;  4X5F A;  2ZZA A;  1AO8 A;  1D1G A;  5HT5 A;  4H95 A;  2W3A A;  5HQZ A;  1RA1 A;  3GI2 A;  1J3K A;  1SEJ A;  4OR7 A;  1RX7 A;  4X5J A;  3NZ9 X;  4G3M A;  4DPD A;  1DDS A;  1JUV A;  3JTW A;  3KGY A;  1DDR A;  3F0V X;  4RGC A;  2W9S A;  3Q1H A;  1HFQ A;  3F0X X;  2BLA A;  3INV A;  4KAK A;  1BOZ A;  1E26 A;  1DR3 A;  3TQB A;  4CD2 A;  3N0H A;  3KJS A;  4XT4 A;  4ECK A;  4H98 A;  1DG5 A;  3M09 A;  4X5H A;  2HM9 A;  1PD8 A;  1RX5 A;  1DRB A;  1QZF A;  4OSG A;  2C2S A;  4I1N A;  1RX1 A;  4HA7 A;  4QHV A;  2D5N A;  3QLR A;  4PST A;  3NTZ A;  3S9U A;  3JWM A;  3TQA A;  3NZ6 X;  3EIG A;  4IXE D;  4XE6 X;  1KLK A;  2FZI A;  1DYR A;  4KEB A;  3HBB A;  3LG4 A;  4QJC A;  3QL3 A;  1TDR A;  4PTJ A;  4G8Z X;  3UM6 A;  2O7P A;  1RC4 A;  1RA3 A;  1IA2 A;  1S3U A;  4LAE X;  3QL0 A;  1RA2 A;  3FQZ A;  1DYJ A;  4PTH A;  2AZN A;  3GHV A;  1AI9 A;  1U72 A;  6DFR A;  1DR4 A;  1DHF A;  2W3W A;  3FYW X;  3IRO A;  3IA5 A;  4FHB A;  3QYL A;  3SAI A;  4LAG X;  1M79 A;  2HQP A;  2OBC A;  3JW5 A;  2G6V A;  3JWK A;  3CLB A;  3CL9 A;  3GHW A;  3FRE X;  4XT5 A;  4XT6 A;  3DRC A;  3FY9 X;  3D80 A;  2CIG A;  4Q0E A;  1LY3 A;  3EEK A;  1RX4 A;  2L28 A;  1YHO A;  5HSR A;  3IRN A;  3M08 A;  3FQO A;  2LF1 A;  4ELG A;  3DAU A;  3S7A A;  4P68 A;  4IXF X;  2DRC A;  3JVX A;  4LEK X;  3D84 X;  4QJZ D;  3K45 A;  4QLF A;  2FZJ A;  3EEM A;  1U70 A;  5EAJ A;  2HXV A;  4KJJ A;  1S3Y A;  3R33 A;  3SA1 A;  1HFP A;  2P4G A;  4HOF A;  1AOE A;  5FDA A;  3VCO A;  4P3R A;  3ZPG A;  2ANQ A;  3UM8 A;  5HF2 X;  1M7A A;  4LAH X;  3K47 A;  3SH2 A;  1DR2 A;  5DFR A;  3F0B X;  3DAT A;  2GD9 A;  4DP3 A;  4KFJ A;  4H97 A;  3SRS X;  1RB2 A;  4I13 A;  3GYF A;  1DR1 A;  1CD2 A;  3FQC A;  1DHI A;  1S3V A;  1IA1 A;  5CCC A;  3DG8 A;  2W3V A;  4QLG A;  4X5G A; 
#chains in the Genus database with same CATH topology
 3K74 A;  4DPH A;  4M7V A;  1DIS A;  1PDB A;  3NZB X;  1VJ3 A;  3QLX A;  1BZF A;  5U27 A;  5HUI A;  1DG8 A;  5HI6 A;  1KMV A;  2B3Z A;  1MVT A;  5DXV A;  4KY4 A;  3SRU X;  3QFX A;  1DLR A;  5HSU A;  4KD7 A;  1RX8 A;  4DFR A;  3S3V A;  3GHC A;  3DFR A;  1DYI A;  1MVS A;  3L3R A;  3NXO A;  3SRQ X;  1J3I A;  1S3W A;  3ROA A;  3DL6 A;  5HF0 X;  3TD8 A;  4H96 A;  3E0B A;  1DLS A;  3F0S X;  4HOG A;  4NX6 A;  1RA8 A;  3NRR A;  2W9H A;  5E8Q A;  4M2X A;  7DFR A;  1RX6 A;  2BL9 A;  4QLE A;  5JG0 X;  1DRA A;  3FRB X;  2H2Q A;  1DR6 A;  4M6J A;  3SGY A;  3FQF A;  4M6L A;  1DHJ A;  4ELB A;  4KLX A;  3RO9 A;  4M7U A;  1IA4 A;  1RA9 A;  2C2T A;  4IXG X;  1DRE A;  2KGK A;  4X5I A;  3I8A X;  3KY8 A;  4NX7 A;  2FZH A;  1RF7 A;  3NZD A;  4P66 A;  3FRA X;  1RG7 A;  4KJL A;  4EJ1 A;  1CZ3 A;  4TU5 X;  1M78 A;  3QLY A;  3CSE A;  1LUD A;  1VDR A;  3IA4 A;  4HOE A;  4PDJ A;  5JA3 A;  3HJ3 A;  3NU0 A;  4KYA A;  3SRR X;  4XRB A;  1LY4 A;  4ELF A;  3SA2 A;  1JOL A;  5HVE A;  3QGT A;  2INQ A;  3SQY X;  4XT7 A;  3NXT A;  4XEC X;  4KNE A;  1U71 A;  2XW7 A;  3CD2 A;  4GH8 A;  2ITH A;  1DYH A;  4G95 A;  3JSU A;  2W9T A;  5HVB A;  4FGH A;  3UM5 A;  2ANO A;  3KJR A;  4Q6A A;  1RX2 A;  2W9G A;  1RE7 A;  4Q67 A;  1J3J A;  3QG2 A;  5HQY A;  3ZPC A;  4Q0D A;  2JYB A;  3TQ9 A;  1HFR A;  2BLC A;  3SRW X;  2QK8 A;  1IA3 A;  4M6K A;  4EIL A;  1DAJ A;  1RX3 A;  3EEL A;  5ECC A;  2CD2 A;  3FL9 A;  3I3R A;  3NXV A;  5ECX A;  1OHJ A;  3OCH A;  4EIG A;  3FYV X;  3DL5 A;  4KY8 A;  3K2H A;  4PSY A;  3JWC A;  4QI9 A;  2BLB A;  3NXR A;  8DFR A;  3F0U X;  4KBN A;  3DGA A;  3F8Y A;  5U26 A;  4KM0 A;  1DRF A;  3RG9 A;  3F8Z A;  5HPB A;  1RX9 A;  5CC9 A;  2DHF A;  3TQ8 A;  1DR7 A;  1DRH A;  4XT8 A;  1PD9 A;  3FQ0 A;  3EEJ A;  3QLZ A;  1DG7 A;  3NZC X;  4ELE A;  2W3M A;  3NXY A;  3JWF A;  1ZDR A;  4FGG A;  2W3B A;  3NZA X;  3SR5 X;  3FS6 A;  1JOM A;  3EX8 A;  5HT4 A;  2OIP A;  4PSS A;  1DR5 A;  4KM2 A;  3IX9 A;  3F0Q X;  4EIZ A;  3JW3 A;  1DF7 A;  3FY8 X;  4P3Q A;  1KMS A;  2D0K A;  3FQV A;  1RD7 A;  4HA9 A;  4KL9 A;  3KFY A;  4ELH A;  4DDR A;  1RB3 A;  3FL8 A;  1RH3 A;  4KJK A;  3F91 A;  1OHK A;  3FRF X;  1DIU A;  3QLS A;  3NXX A;  3FRD X;  3IRM A;  3QYO A;  3OAF A;  3QLW A;  4X5F A;  2ZZA A;  1AO8 A;  1D1G A;  5HT5 A;  4H95 A;  2W3A A;  5HQZ A;  1RA1 A;  3GI2 A;  1J3K A;  1SEJ A;  4OR7 A;  1RX7 A;  4X5J A;  3NZ9 X;  4G3M A;  4DPD A;  1DDS A;  1JUV A;  3JTW A;  3KGY A;  1DDR A;  3F0V X;  4RGC A;  2W9S A;  3Q1H A;  1HFQ A;  3F0X X;  2BLA A;  3INV A;  4KAK A;  1BOZ A;  1E26 A;  1DR3 A;  3TQB A;  4CD2 A;  3N0H A;  3KJS A;  4XT4 A;  4ECK A;  4H98 A;  1DG5 A;  3M09 A;  4X5H A;  2HM9 A;  1PD8 A;  1RX5 A;  1DRB A;  1QZF A;  4OSG A;  2C2S A;  4I1N A;  1RX1 A;  4HA7 A;  4QHV A;  2D5N A;  3QLR A;  4PST A;  3NTZ A;  3S9U A;  3JWM A;  3TQA A;  3NZ6 X;  3EIG A;  4IXE D;  4XE6 X;  1KLK A;  2FZI A;  1DYR A;  4KEB A;  3HBB A;  3LG4 A;  4QJC A;  3QL3 A;  1TDR A;  4PTJ A;  4G8Z X;  3UM6 A;  2O7P A;  1RC4 A;  1RA3 A;  1IA2 A;  1S3U A;  4LAE X;  3QL0 A;  1RA2 A;  3FQZ A;  1DYJ A;  4PTH A;  2AZN A;  3GHV A;  1AI9 A;  1U72 A;  6DFR A;  1DR4 A;  1DHF A;  2W3W A;  3FYW X;  3IRO A;  3IA5 A;  4FHB A;  3QYL A;  3SAI A;  4LAG X;  1M79 A;  2HQP A;  2OBC A;  3JW5 A;  2G6V A;  3JWK A;  3CLB A;  3CL9 A;  3GHW A;  3FRE X;  4XT5 A;  4XT6 A;  3DRC A;  3FY9 X;  3D80 A;  2CIG A;  4Q0E A;  1LY3 A;  3EEK A;  1RX4 A;  2L28 A;  1YHO A;  5HSR A;  3IRN A;  3M08 A;  3FQO A;  2LF1 A;  4ELG A;  3DAU A;  3S7A A;  4P68 A;  4IXF X;  2DRC A;  3JVX A;  4LEK X;  3D84 X;  4QJZ D;  3K45 A;  4QLF A;  2FZJ A;  3EEM A;  1U70 A;  5EAJ A;  2HXV A;  4KJJ A;  1S3Y A;  3R33 A;  3SA1 A;  1HFP A;  2P4G A;  4HOF A;  1AOE A;  5FDA A;  3VCO A;  4P3R A;  3ZPG A;  2ANQ A;  3UM8 A;  5HF2 X;  1M7A A;  4LAH X;  3K47 A;  3SH2 A;  1DR2 A;  5DFR A;  3F0B X;  3DAT A;  2GD9 A;  4DP3 A;  4KFJ A;  4H97 A;  3SRS X;  1RB2 A;  4I13 A;  3GYF A;  1DR1 A;  1CD2 A;  3FQC A;  1DHI A;  1S3V A;  1IA1 A;  5CCC A;  3DG8 A;  2W3V A;  4QLG A;  4X5G A; 
#chains in the Genus database with same CATH homology
 3K74 A;  4DPH A;  4M7V A;  1DIS A;  1PDB A;  3NZB X;  1VJ3 A;  3QLX A;  1BZF A;  5U27 A;  5HUI A;  1DG8 A;  5HI6 A;  1KMV A;  2B3Z A;  1MVT A;  5DXV A;  4KY4 A;  3SRU X;  3QFX A;  1DLR A;  5HSU A;  4KD7 A;  1RX8 A;  4DFR A;  3S3V A;  3GHC A;  3DFR A;  1DYI A;  1MVS A;  3L3R A;  3NXO A;  3SRQ X;  1J3I A;  1S3W A;  3ROA A;  3DL6 A;  5HF0 X;  3TD8 A;  4H96 A;  3E0B A;  1DLS A;  3F0S X;  4HOG A;  4NX6 A;  1RA8 A;  3NRR A;  2W9H A;  5E8Q A;  4M2X A;  7DFR A;  1RX6 A;  2BL9 A;  4QLE A;  5JG0 X;  1DRA A;  3FRB X;  2H2Q A;  1DR6 A;  4M6J A;  3SGY A;  3FQF A;  4M6L A;  1DHJ A;  4ELB A;  4KLX A;  3RO9 A;  4M7U A;  1IA4 A;  1RA9 A;  2C2T A;  4IXG X;  1DRE A;  2KGK A;  4X5I A;  3I8A X;  3KY8 A;  4NX7 A;  2FZH A;  1RF7 A;  3NZD A;  4P66 A;  3FRA X;  1RG7 A;  4KJL A;  4EJ1 A;  1CZ3 A;  4TU5 X;  1M78 A;  3QLY A;  3CSE A;  1LUD A;  1VDR A;  3IA4 A;  4HOE A;  4PDJ A;  5JA3 A;  3HJ3 A;  3NU0 A;  4KYA A;  3SRR X;  4XRB A;  1LY4 A;  4ELF A;  3SA2 A;  1JOL A;  5HVE A;  3QGT A;  2INQ A;  3SQY X;  4XT7 A;  3NXT A;  4XEC X;  4KNE A;  1U71 A;  2XW7 A;  3CD2 A;  4GH8 A;  2ITH A;  1DYH A;  4G95 A;  3JSU A;  2W9T A;  5HVB A;  4FGH A;  3UM5 A;  2ANO A;  3KJR A;  4Q6A A;  1RX2 A;  2W9G A;  1RE7 A;  4Q67 A;  1J3J A;  3QG2 A;  5HQY A;  3ZPC A;  4Q0D A;  2JYB A;  3TQ9 A;  1HFR A;  2BLC A;  3SRW X;  2QK8 A;  1IA3 A;  4M6K A;  4EIL A;  1DAJ A;  1RX3 A;  3EEL A;  5ECC A;  2CD2 A;  3FL9 A;  3I3R A;  3NXV A;  5ECX A;  1OHJ A;  3OCH A;  4EIG A;  3FYV X;  3DL5 A;  4KY8 A;  3K2H A;  4PSY A;  3JWC A;  4QI9 A;  2BLB A;  3NXR A;  8DFR A;  3F0U X;  4KBN A;  3DGA A;  3F8Y A;  5U26 A;  4KM0 A;  1DRF A;  3RG9 A;  3F8Z A;  5HPB A;  1RX9 A;  5CC9 A;  2DHF A;  3TQ8 A;  1DR7 A;  1DRH A;  4XT8 A;  1PD9 A;  3FQ0 A;  3EEJ A;  3QLZ A;  1DG7 A;  3NZC X;  4ELE A;  2W3M A;  3NXY A;  3JWF A;  1ZDR A;  4FGG A;  2W3B A;  3NZA X;  3SR5 X;  3FS6 A;  1JOM A;  3EX8 A;  5HT4 A;  2OIP A;  4PSS A;  1DR5 A;  4KM2 A;  3IX9 A;  3F0Q X;  4EIZ A;  3JW3 A;  1DF7 A;  3FY8 X;  4P3Q A;  1KMS A;  2D0K A;  3FQV A;  1RD7 A;  4HA9 A;  4KL9 A;  3KFY A;  4ELH A;  4DDR A;  1RB3 A;  3FL8 A;  1RH3 A;  4KJK A;  3F91 A;  1OHK A;  3FRF X;  1DIU A;  3QLS A;  3NXX A;  3FRD X;  3IRM A;  3QYO A;  3OAF A;  3QLW A;  4X5F A;  2ZZA A;  1AO8 A;  1D1G A;  5HT5 A;  4H95 A;  2W3A A;  5HQZ A;  1RA1 A;  3GI2 A;  1J3K A;  1SEJ A;  4OR7 A;  1RX7 A;  4X5J A;  3NZ9 X;  4G3M A;  4DPD A;  1DDS A;  1JUV A;  3JTW A;  3KGY A;  1DDR A;  3F0V X;  4RGC A;  2W9S A;  3Q1H A;  1HFQ A;  3F0X X;  2BLA A;  3INV A;  4KAK A;  1BOZ A;  1E26 A;  1DR3 A;  3TQB A;  4CD2 A;  3N0H A;  3KJS A;  4XT4 A;  4ECK A;  4H98 A;  1DG5 A;  3M09 A;  4X5H A;  2HM9 A;  1PD8 A;  1RX5 A;  1DRB A;  1QZF A;  4OSG A;  2C2S A;  4I1N A;  1RX1 A;  4HA7 A;  4QHV A;  2D5N A;  3QLR A;  4PST A;  3NTZ A;  3S9U A;  3JWM A;  3TQA A;  3NZ6 X;  3EIG A;  4IXE D;  4XE6 X;  1KLK A;  2FZI A;  1DYR A;  4KEB A;  3HBB A;  3LG4 A;  4QJC A;  3QL3 A;  1TDR A;  4PTJ A;  4G8Z X;  3UM6 A;  2O7P A;  1RC4 A;  1RA3 A;  1IA2 A;  1S3U A;  4LAE X;  3QL0 A;  1RA2 A;  3FQZ A;  1DYJ A;  4PTH A;  2AZN A;  3GHV A;  1AI9 A;  1U72 A;  6DFR A;  1DR4 A;  1DHF A;  2W3W A;  3FYW X;  3IRO A;  3IA5 A;  4FHB A;  3QYL A;  3SAI A;  4LAG X;  1M79 A;  2HQP A;  2OBC A;  3JW5 A;  2G6V A;  3JWK A;  3CLB A;  3CL9 A;  3GHW A;  3FRE X;  4XT5 A;  4XT6 A;  3DRC A;  3FY9 X;  3D80 A;  2CIG A;  4Q0E A;  1LY3 A;  3EEK A;  1RX4 A;  2L28 A;  1YHO A;  5HSR A;  3IRN A;  3M08 A;  3FQO A;  2LF1 A;  4ELG A;  3DAU A;  3S7A A;  4P68 A;  4IXF X;  2DRC A;  3JVX A;  4LEK X;  3D84 X;  4QJZ D;  3K45 A;  4QLF A;  2FZJ A;  3EEM A;  1U70 A;  5EAJ A;  2HXV A;  4KJJ A;  1S3Y A;  3R33 A;  3SA1 A;  1HFP A;  2P4G A;  4HOF A;  1AOE A;  5FDA A;  3VCO A;  4P3R A;  3ZPG A;  2ANQ A;  3UM8 A;  5HF2 X;  1M7A A;  4LAH X;  3K47 A;  3SH2 A;  1DR2 A;  5DFR A;  3F0B X;  3DAT A;  2GD9 A;  4DP3 A;  4KFJ A;  4H97 A;  3SRS X;  1RB2 A;  4I13 A;  3GYF A;  1DR1 A;  1CD2 A;  3FQC A;  1DHI A;  1S3V A;  1IA1 A;  5CCC A;  3DG8 A;  2W3V A;  4QLG A;  4X5G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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