3GHVA

Human dihydrofolate reductase q35k/n64f double mutant inhibitor complex
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFKRMTTTSSVEGKQNLVIMGKKTWFSIPEKFRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Dihydrofolate reductase
total genus 53
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-03-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3ghvA00
1AI9A 4XT8A 4DP3A 1RX9A 2CD2A 3FRDX 1DYRA 1M7AA 1VJ3A 3GHWA 3CSEA 4X5FA 1KMSA 3I8AX 1RB2A 1D1GA 2AZNA 3F0UX 1MVSA 4IXED 3INVA 4Q0EA 3S7AA 4HOFA 4KD7A 4X5JA 3SA2A 4XT6A 4XE6X 1RE7A 3JSUA 4ELEA 3UM8A 1RA3A 1QZFA 3SAIA 1S3WA 3FQCA 3FQOA 5HI6A 1DHJA 1DYIA 3IA5A 3QLWA 1DAJA 3FQVA 3EEMA 3IA4A 4NX7A 5HVBA 4KFJA 1AOEA 5DFRA 3ZPGA 3OAFA 1RB3A 4HOEA 1DRHA 1KLKA 3SH2A 3TQAA 5HQZA 4HOGA 4GH8A 3FRAX 4KJKA 1HFRA 3QLXA 3NXYA 3F0QX 3RG9A 1DR1A 3HBBA 1DF7A 3FREX 4H96A 5HVEA 3F0XX 1DR7A 4H98A 8DFRA 4KJLA 4ECKA 4Q0DA 2QK8A 3KFYA 1DLRA 2JYBA 3SRUX 4ELGA 3NXTA 3N0HA 4QHVA 1DYHA 1ZDRA 3NZ9X 4ELBA 3FYVX 1RH3A 1DISA 2CIGA 3DGAA 1RG7A 2C2TA 4EILA 2W3WA 3QLRA 5E8QA 3NZCX 1RX1A 3JWKA 3DL5A 4KY4A 1AO8A 3JTWA 1DHIA 1LY4A 4ELFA 1IA4A 3EEJA 3DRCA 3Q1HA 2W3BA 3IRMA 4KAKA 1CZ3A 3IROA 5HF2X 3FQFA 1CD2A 4KBNA 4TU5X 4PTHA 4PSYA 3SRSX 4HA9A 2LF1A 3IRNA 1DG8A 1DR5A 4XECX 4XRBA 2XW7A 3GHVA 2D0KA 3TQ9A 1OHJA 1VDRA 1J3KA 3K74A 2HM9A 5HF0X 7DFRA 2ITHA 2DHFA 3DL6A 1RX7A 1J3JA 3K2HA 3EELA 5ECXA 2FZHA 3QL3A 3JWCA 1PD9A 3R33A 1KMVA 1IA1A 4M6JA 2BLBA 3JVXA 4Q6AA 2W9SA 4H97A 4KY8A 4KNEA 3DG8A 1JOLA 1RF7A 4G95A 1OHKA 3GI2A 4PDJA 4QJZD 5ECCA 1RA2A 1BOZA 3ZPCA 3F8YA 2H2QA 3SA1A 1DHFA 1BZFA 3QGTA 3KJSA 4P3RA 3K47A 1JUVA 4LAHX 3TQBA 1JOMA 4KLXA 3GHCA 3NU0A 1S3UA 5HT4A 3FL9A 3NRRA 4FGGA 1IA3A 1S3YA 2ZZAA 1PDBA 3LG4A 3KY8A 4QLFA 1RX8A 1DRFA 4X5GA 5EAJA 3JW3A 3UM5A 1IA2A 1RX4A 3EX8A 3GYFA 4I13A 1M79A 4DFRA 1DRAA 3CLBA 5JG0X 4XT5A 1TDRA 3FY8X 2W9TA 5CC9A 3CL9A 3FQ0A 3M08A 5FDAA 3F8ZA 4X5IA 3D84X 1HFPA 1DR4A 3OCHA 4QLGA 5U27A 1U71A 4LAEX 3FL8A 4I1NA 4IXGX 5HUIA 3SQYX 2G6VA 2O7PA 3JWMA 4Q67A 1E26A 3NZAX 1YHOA 3QG2A 3KJRA 5CCCA 5JA3A 3FY9X 3VCOA 2FZIA 4KL9A 1DR2A 3QLSA 4DPHA 4XT7A 4M7VA 2ANQA 1DREA 3D80A 3NXXA 3QYLA 4M2XA 3IX9A 3ROAA 4DDRA 1LY3A 3I3RA 1DR6A 3F0BX 1M78A 3FQZA 1RX5A 2KGKA 3SRQX 4FGHA 3L3RA 1HFQA 2FZJA 3NXOA 4FHBA 4HA7A 5DXVA 2HXVA 4M6KA 4QLEA 3EIGA 1S3VA 2W3AA 2C2SA 3QLZA 6DFRA 3JWFA 3UM6A 1DR3A 5HPBA 4NX6A 3FRBX 4IXFX 2OIPA 3DAUA 3SR5X 1LUDA 5HSUA 3NTZA 3EEKA 1DG5A 3SRWX 1MVTA 3SGYA 4PTJA 3K45A 3NZBX 2OBCA 3E0BA 4QJCA 1RA8A 3DATA 3F0VX 4G3MA 2DRCA 4PSTA 3FRFX 3NZ6X 1RC4A 4KEBA 5HQYA 4KYAA 3NXVA 4P68A 3JW5A 3RO9A 3F91A 4XT4A 1DG7A 3DFRA 4CD2A 3TQ8A 2W9HA 1SEJA 4OSGA 4ELHA 4KJJA 4KM0A 1U70A 4P3QA 4LEKX 3HJ3A 3NZDA 5HSRA 2GD9A 3QYOA 3S9UA 3QL0A 1RA9A 2BLCA 1DIUA 1RX2A 1DLSA 4H95A 4M6LA 2L28A 2BL9A 1DYJA 3FYWX 5HT5A 2BLAA 3QFXA 3F0SX 3S3VA 4EJ1A 2D5NA 3NXRA 2W9GA 4EIZA 4X5HA 3KGYA 4EIGA 3TD8A 2ANOA 2B3ZA 2HQPA 4QI9A 1RX6A 2W3VA 4OR7A 3FS6A 5U26A 4M7UA 1RX3A 1DDSA 4DPDA 4RGCA 3SRRX 1RD7A 2INQA 3QLYA 4KM2A 1DRBA 2P4GA 1PD8A 3CD2A 4LAGX 4PSSA 3M09A 2W3MA 1J3IA 4G8ZX 1U72A 1RA1A 1DDRA 4P66A
chains in the Genus database with same CATH superfamily
1AI9A 4XT8A 4DP3A 1RX9A 2CD2A 3FRDX 1DYRA 1M7AA 1VJ3A 3GHWA 3CSEA 4X5FA 1KMSA 3I8AX 1RB2A 1D1GA 2AZNA 3F0UX 1MVSA 4IXED 3INVA 4Q0EA 3S7AA 4HOFA 4KD7A 4X5JA 3SA2A 4XT6A 4XE6X 1RE7A 3JSUA 4ELEA 3UM8A 1RA3A 1QZFA 3SAIA 1S3WA 3FQCA 3FQOA 5HI6A 1DHJA 1DYIA 3IA5A 3QLWA 1DAJA 3FQVA 3EEMA 3IA4A 4NX7A 5HVBA 4KFJA 1AOEA 5DFRA 3ZPGA 3OAFA 1RB3A 4HOEA 1DRHA 1KLKA 3SH2A 3TQAA 5HQZA 4HOGA 4GH8A 3FRAX 4KJKA 1HFRA 3QLXA 3NXYA 3F0QX 3RG9A 1DR1A 3HBBA 1DF7A 3FREX 4H96A 5HVEA 3F0XX 1DR7A 4H98A 8DFRA 4KJLA 4ECKA 4Q0DA 2QK8A 3KFYA 1DLRA 2JYBA 3SRUX 4ELGA 3NXTA 3N0HA 4QHVA 1DYHA 1ZDRA 3NZ9X 4ELBA 3FYVX 1RH3A 1DISA 2CIGA 3DGAA 1RG7A 2C2TA 4EILA 2W3WA 3QLRA 5E8QA 3NZCX 1RX1A 3JWKA 3DL5A 4KY4A 1AO8A 3JTWA 1DHIA 1LY4A 4ELFA 1IA4A 3EEJA 3DRCA 3Q1HA 2W3BA 3IRMA 4KAKA 1CZ3A 3IROA 5HF2X 3FQFA 1CD2A 4KBNA 4TU5X 4PTHA 4PSYA 3SRSX 4HA9A 2LF1A 3IRNA 1DG8A 1DR5A 4XECX 4XRBA 2XW7A 3GHVA 2D0KA 3TQ9A 1OHJA 1VDRA 1J3KA 3K74A 2HM9A 5HF0X 7DFRA 2ITHA 2DHFA 3DL6A 1RX7A 1J3JA 3K2HA 3EELA 5ECXA 2FZHA 3QL3A 3JWCA 1PD9A 3R33A 1KMVA 1IA1A 4M6JA 2BLBA 3JVXA 4Q6AA 2W9SA 4H97A 4KY8A 4KNEA 3DG8A 1JOLA 1RF7A 4G95A 1OHKA 3GI2A 4PDJA 4QJZD 5ECCA 1RA2A 1BOZA 3ZPCA 3F8YA 2H2QA 3SA1A 1DHFA 1BZFA 3QGTA 3KJSA 4P3RA 3K47A 1JUVA 4LAHX 3TQBA 1JOMA 4KLXA 3GHCA 3NU0A 1S3UA 5HT4A 3FL9A 3NRRA 4FGGA 1IA3A 1S3YA 2ZZAA 1PDBA 3LG4A 3KY8A 4QLFA 1RX8A 1DRFA 4X5GA 5EAJA 3JW3A 3UM5A 1IA2A 1RX4A 3EX8A 3GYFA 4I13A 1M79A 4DFRA 1DRAA 3CLBA 5JG0X 4XT5A 1TDRA 3FY8X 2W9TA 5CC9A 3CL9A 3FQ0A 3M08A 5FDAA 3F8ZA 4X5IA 3D84X 1HFPA 1DR4A 3OCHA 4QLGA 5U27A 1U71A 4LAEX 3FL8A 4I1NA 4IXGX 5HUIA 3SQYX 2G6VA 2O7PA 3JWMA 4Q67A 1E26A 3NZAX 1YHOA 3QG2A 3KJRA 5CCCA 5JA3A 3FY9X 3VCOA 2FZIA 4KL9A 1DR2A 3QLSA 4DPHA 4XT7A 4M7VA 2ANQA 1DREA 3D80A 3NXXA 3QYLA 4M2XA 3IX9A 3ROAA 4DDRA 1LY3A 3I3RA 1DR6A 3F0BX 1M78A 3FQZA 1RX5A 2KGKA 3SRQX 4FGHA 3L3RA 1HFQA 2FZJA 3NXOA 4FHBA 4HA7A 5DXVA 2HXVA 4M6KA 4QLEA 3EIGA 1S3VA 2W3AA 2C2SA 3QLZA 6DFRA 3JWFA 3UM6A 1DR3A 5HPBA 4NX6A 3FRBX 4IXFX 2OIPA 3DAUA 3SR5X 1LUDA 5HSUA 3NTZA 3EEKA 1DG5A 3SRWX 1MVTA 3SGYA 4PTJA 3K45A 3NZBX 2OBCA 3E0BA 4QJCA 1RA8A 3DATA 3F0VX 4G3MA 2DRCA 4PSTA 3FRFX 3NZ6X 1RC4A 4KEBA 5HQYA 4KYAA 3NXVA 4P68A 3JW5A 3RO9A 3F91A 4XT4A 1DG7A 3DFRA 4CD2A 3TQ8A 2W9HA 1SEJA 4OSGA 4ELHA 4KJJA 4KM0A 1U70A 4P3QA 4LEKX 3HJ3A 3NZDA 5HSRA 2GD9A 3QYOA 3S9UA 3QL0A 1RA9A 2BLCA 1DIUA 1RX2A 1DLSA 4H95A 4M6LA 2L28A 2BL9A 1DYJA 3FYWX 5HT5A 2BLAA 3QFXA 3F0SX 3S3VA 4EJ1A 2D5NA 3NXRA 2W9GA 4EIZA 4X5HA 3KGYA 4EIGA 3TD8A 2ANOA 2B3ZA 2HQPA 4QI9A 1RX6A 2W3VA 4OR7A 3FS6A 5U26A 4M7UA 1RX3A 1DDSA 4DPDA 4RGCA 3SRRX 1RD7A 2INQA 3QLYA 4KM2A 1DRBA 2P4GA 1PD8A 3CD2A 4LAGX 4PSSA 3M09A 2W3MA 1J3IA 4G8ZX 1U72A 1RA1A 1DDRA 4P66A
chains in the Genus database with same CATH topology
1AI9A 4XT8A 4DP3A 1RX9A 2CD2A 3FRDX 1DYRA 1M7AA 1VJ3A 3GHWA 3CSEA 4X5FA 1KMSA 3I8AX 1RB2A 1D1GA 2AZNA 3F0UX 1MVSA 4IXED 3INVA 4Q0EA 3S7AA 4HOFA 4KD7A 4X5JA 3SA2A 4XT6A 4XE6X 1RE7A 3JSUA 4ELEA 3UM8A 1RA3A 1QZFA 3SAIA 1S3WA 3FQCA 3FQOA 5HI6A 1DHJA 1DYIA 3IA5A 3QLWA 1DAJA 3FQVA 3EEMA 3IA4A 4NX7A 5HVBA 4KFJA 1AOEA 5DFRA 3ZPGA 3OAFA 1RB3A 4HOEA 1DRHA 1KLKA 3SH2A 3TQAA 5HQZA 4HOGA 4GH8A 3FRAX 4KJKA 1HFRA 3QLXA 3NXYA 3F0QX 3RG9A 1DR1A 3HBBA 1DF7A 3FREX 4H96A 5HVEA 3F0XX 1DR7A 4H98A 8DFRA 4KJLA 4ECKA 4Q0DA 2QK8A 3KFYA 1DLRA 2JYBA 3SRUX 4ELGA 3NXTA 3N0HA 4QHVA 1DYHA 1ZDRA 3NZ9X 4ELBA 3FYVX 1RH3A 1DISA 2CIGA 3DGAA 1RG7A 2C2TA 4EILA 2W3WA 3QLRA 5E8QA 3NZCX 1RX1A 3JWKA 3DL5A 4KY4A 1AO8A 3JTWA 1DHIA 1LY4A 4ELFA 1IA4A 3EEJA 3DRCA 3Q1HA 2W3BA 3IRMA 4KAKA 1CZ3A 3IROA 5HF2X 3FQFA 1CD2A 4KBNA 4TU5X 4PTHA 4PSYA 3SRSX 4HA9A 2LF1A 3IRNA 1DG8A 1DR5A 4XECX 4XRBA 2XW7A 3GHVA 2D0KA 3TQ9A 1OHJA 1VDRA 1J3KA 3K74A 2HM9A 5HF0X 7DFRA 2ITHA 2DHFA 3DL6A 1RX7A 1J3JA 3K2HA 3EELA 5ECXA 2FZHA 3QL3A 3JWCA 1PD9A 3R33A 1KMVA 1IA1A 4M6JA 2BLBA 3JVXA 4Q6AA 2W9SA 4H97A 4KY8A 4KNEA 3DG8A 1JOLA 1RF7A 4G95A 1OHKA 3GI2A 4PDJA 4QJZD 5ECCA 1RA2A 1BOZA 3ZPCA 3F8YA 2H2QA 3SA1A 1DHFA 1BZFA 3QGTA 3KJSA 4P3RA 3K47A 1JUVA 4LAHX 3TQBA 1JOMA 4KLXA 3GHCA 3NU0A 1S3UA 5HT4A 3FL9A 3NRRA 4FGGA 1IA3A 1S3YA 2ZZAA 1PDBA 3LG4A 3KY8A 4QLFA 1RX8A 1DRFA 4X5GA 5EAJA 3JW3A 3UM5A 1IA2A 1RX4A 3EX8A 3GYFA 4I13A 1M79A 4DFRA 1DRAA 3CLBA 5JG0X 4XT5A 1TDRA 3FY8X 2W9TA 5CC9A 3CL9A 3FQ0A 3M08A 5FDAA 3F8ZA 4X5IA 3D84X 1HFPA 1DR4A 3OCHA 4QLGA 5U27A 1U71A 4LAEX 3FL8A 4I1NA 4IXGX 5HUIA 3SQYX 2G6VA 2O7PA 3JWMA 4Q67A 1E26A 3NZAX 1YHOA 3QG2A 3KJRA 5CCCA 5JA3A 3FY9X 3VCOA 2FZIA 4KL9A 1DR2A 3QLSA 4DPHA 4XT7A 4M7VA 2ANQA 1DREA 3D80A 3NXXA 3QYLA 4M2XA 3IX9A 3ROAA 4DDRA 1LY3A 3I3RA 1DR6A 3F0BX 1M78A 3FQZA 1RX5A 2KGKA 3SRQX 4FGHA 3L3RA 1HFQA 2FZJA 3NXOA 4FHBA 4HA7A 5DXVA 2HXVA 4M6KA 4QLEA 3EIGA 1S3VA 2W3AA 2C2SA 3QLZA 6DFRA 3JWFA 3UM6A 1DR3A 5HPBA 4NX6A 3FRBX 4IXFX 2OIPA 3DAUA 3SR5X 1LUDA 5HSUA 3NTZA 3EEKA 1DG5A 3SRWX 1MVTA 3SGYA 4PTJA 3K45A 3NZBX 2OBCA 3E0BA 4QJCA 1RA8A 3DATA 3F0VX 4G3MA 2DRCA 4PSTA 3FRFX 3NZ6X 1RC4A 4KEBA 5HQYA 4KYAA 3NXVA 4P68A 3JW5A 3RO9A 3F91A 4XT4A 1DG7A 3DFRA 4CD2A 3TQ8A 2W9HA 1SEJA 4OSGA 4ELHA 4KJJA 4KM0A 1U70A 4P3QA 4LEKX 3HJ3A 3NZDA 5HSRA 2GD9A 3QYOA 3S9UA 3QL0A 1RA9A 2BLCA 1DIUA 1RX2A 1DLSA 4H95A 4M6LA 2L28A 2BL9A 1DYJA 3FYWX 5HT5A 2BLAA 3QFXA 3F0SX 3S3VA 4EJ1A 2D5NA 3NXRA 2W9GA 4EIZA 4X5HA 3KGYA 4EIGA 3TD8A 2ANOA 2B3ZA 2HQPA 4QI9A 1RX6A 2W3VA 4OR7A 3FS6A 5U26A 4M7UA 1RX3A 1DDSA 4DPDA 4RGCA 3SRRX 1RD7A 2INQA 3QLYA 4KM2A 1DRBA 2P4GA 1PD8A 3CD2A 4LAGX 4PSSA 3M09A 2W3MA 1J3IA 4G8ZX 1U72A 1RA1A 1DDRA 4P66A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AI9 A;  4XT8 A;  4DP3 A;  1RX9 A;  2CD2 A;  3FRD X;  1DYR A;  1M7A A;  1VJ3 A;  3GHW A;  3CSE A;  4X5F A;  1KMS A;  3I8A X;  1RB2 A;  1D1G A;  2AZN A;  3F0U X;  1MVS A;  4IXE D;  3INV A;  4Q0E A;  3S7A A;  4HOF A;  4KD7 A;  4X5J A;  3SA2 A;  4XT6 A;  4XE6 X;  1RE7 A;  3JSU A;  4ELE A;  3UM8 A;  1RA3 A;  1QZF A;  3SAI A;  1S3W A;  3FQC A;  3FQO A;  5HI6 A;  1DHJ A;  1DYI A;  3IA5 A;  3QLW A;  1DAJ A;  3FQV A;  3EEM A;  3IA4 A;  4NX7 A;  5HVB A;  4KFJ A;  1AOE A;  5DFR A;  3ZPG A;  3OAF A;  1RB3 A;  4HOE A;  1DRH A;  1KLK A;  3SH2 A;  3TQA A;  5HQZ A;  4HOG A;  4GH8 A;  3FRA X;  4KJK A;  1HFR A;  3QLX A;  3NXY A;  3F0Q X;  3RG9 A;  1DR1 A;  3HBB A;  1DF7 A;  3FRE X;  4H96 A;  5HVE A;  3F0X X;  1DR7 A;  4H98 A;  8DFR A;  4KJL A;  4ECK A;  4Q0D A;  2QK8 A;  3KFY A;  1DLR A;  2JYB A;  3SRU X;  4ELG A;  3NXT A;  3N0H A;  4QHV A;  1DYH A;  1ZDR A;  3NZ9 X;  4ELB A;  3FYV X;  1RH3 A;  1DIS A;  2CIG A;  3DGA A;  1RG7 A;  2C2T A;  4EIL A;  2W3W A;  3QLR A;  5E8Q A;  3NZC X;  1RX1 A;  3JWK A;  3DL5 A;  4KY4 A;  1AO8 A;  3JTW A;  1DHI A;  1LY4 A;  4ELF A;  1IA4 A;  3EEJ A;  3DRC A;  3Q1H A;  2W3B A;  3IRM A;  4KAK A;  1CZ3 A;  3IRO A;  5HF2 X;  3FQF A;  1CD2 A;  4KBN A;  4TU5 X;  4PTH A;  4PSY A;  3SRS X;  4HA9 A;  2LF1 A;  3IRN A;  1DG8 A;  1DR5 A;  4XEC X;  4XRB A;  2XW7 A;  3GHV A;  2D0K A;  3TQ9 A;  1OHJ A;  1VDR A;  1J3K A;  3K74 A;  2HM9 A;  5HF0 X;  7DFR A;  2ITH A;  2DHF A;  3DL6 A;  1RX7 A;  1J3J A;  3K2H A;  3EEL A;  5ECX A;  2FZH A;  3QL3 A;  3JWC A;  1PD9 A;  3R33 A;  1KMV A;  1IA1 A;  4M6J A;  2BLB A;  3JVX A;  4Q6A A;  2W9S A;  4H97 A;  4KY8 A;  4KNE A;  3DG8 A;  1JOL A;  1RF7 A;  4G95 A;  1OHK A;  3GI2 A;  4PDJ A;  4QJZ D;  5ECC A;  1RA2 A;  1BOZ A;  3ZPC A;  3F8Y A;  2H2Q A;  3SA1 A;  1DHF A;  1BZF A;  3QGT A;  3KJS A;  4P3R A;  3K47 A;  1JUV A;  4LAH X;  3TQB A;  1JOM A;  4KLX A;  3GHC A;  3NU0 A;  1S3U A;  5HT4 A;  3FL9 A;  3NRR A;  4FGG A;  1IA3 A;  1S3Y A;  2ZZA A;  1PDB A;  3LG4 A;  3KY8 A;  4QLF A;  1RX8 A;  1DRF A;  4X5G A;  5EAJ A;  3JW3 A;  3UM5 A;  1IA2 A;  1RX4 A;  3EX8 A;  3GYF A;  4I13 A;  1M79 A;  4DFR A;  1DRA A;  3CLB A;  5JG0 X;  4XT5 A;  1TDR A;  3FY8 X;  2W9T A;  5CC9 A;  3CL9 A;  3FQ0 A;  3M08 A;  5FDA A;  3F8Z A;  4X5I A;  3D84 X;  1HFP A;  1DR4 A;  3OCH A;  4QLG A;  5U27 A;  1U71 A;  4LAE X;  3FL8 A;  4I1N A;  4IXG X;  5HUI A;  3SQY X;  2G6V A;  2O7P A;  3JWM A;  4Q67 A;  1E26 A;  3NZA X;  1YHO A;  3QG2 A;  3KJR A;  5CCC A;  5JA3 A;  3FY9 X;  3VCO A;  2FZI A;  4KL9 A;  1DR2 A;  3QLS A;  4DPH A;  4XT7 A;  4M7V A;  2ANQ A;  1DRE A;  3D80 A;  3NXX A;  3QYL A;  4M2X A;  3IX9 A;  3ROA A;  4DDR A;  1LY3 A;  3I3R A;  1DR6 A;  3F0B X;  1M78 A;  3FQZ A;  1RX5 A;  2KGK A;  3SRQ X;  4FGH A;  3L3R A;  1HFQ A;  2FZJ A;  3NXO A;  4FHB A;  4HA7 A;  5DXV A;  2HXV A;  4M6K A;  4QLE A;  3EIG A;  1S3V A;  2W3A A;  2C2S A;  3QLZ A;  6DFR A;  3JWF A;  3UM6 A;  1DR3 A;  5HPB A;  4NX6 A;  3FRB X;  4IXF X;  2OIP A;  3DAU A;  3SR5 X;  1LUD A;  5HSU A;  3NTZ A;  3EEK A;  1DG5 A;  3SRW X;  1MVT A;  3SGY A;  4PTJ A;  3K45 A;  3NZB X;  2OBC A;  3E0B A;  4QJC A;  1RA8 A;  3DAT A;  3F0V X;  4G3M A;  2DRC A;  4PST A;  3FRF X;  3NZ6 X;  1RC4 A;  4KEB A;  5HQY A;  4KYA A;  3NXV A;  4P68 A;  3JW5 A;  3RO9 A;  3F91 A;  4XT4 A;  1DG7 A;  3DFR A;  4CD2 A;  3TQ8 A;  2W9H A;  1SEJ A;  4OSG A;  4ELH A;  4KJJ A;  4KM0 A;  1U70 A;  4P3Q A;  4LEK X;  3HJ3 A;  3NZD A;  5HSR A;  2GD9 A;  3QYO A;  3S9U A;  3QL0 A;  1RA9 A;  2BLC A;  1DIU A;  1RX2 A;  1DLS A;  4H95 A;  4M6L A;  2L28 A;  2BL9 A;  1DYJ A;  3FYW X;  5HT5 A;  2BLA A;  3QFX A;  3F0S X;  3S3V A;  4EJ1 A;  2D5N A;  3NXR A;  2W9G A;  4EIZ A;  4X5H A;  3KGY A;  4EIG A;  3TD8 A;  2ANO A;  2B3Z A;  2HQP A;  4QI9 A;  1RX6 A;  2W3V A;  4OR7 A;  3FS6 A;  5U26 A;  4M7U A;  1RX3 A;  1DDS A;  4DPD A;  4RGC A;  3SRR X;  1RD7 A;  2INQ A;  3QLY A;  4KM2 A;  1DRB A;  2P4G A;  1PD8 A;  3CD2 A;  4LAG X;  4PSS A;  3M09 A;  2W3M A;  1J3I A;  4G8Z X;  1U72 A;  1RA1 A;  1DDR A;  4P66 A; 
#chains in the Genus database with same CATH topology
 1AI9 A;  4XT8 A;  4DP3 A;  1RX9 A;  2CD2 A;  3FRD X;  1DYR A;  1M7A A;  1VJ3 A;  3GHW A;  3CSE A;  4X5F A;  1KMS A;  3I8A X;  1RB2 A;  1D1G A;  2AZN A;  3F0U X;  1MVS A;  4IXE D;  3INV A;  4Q0E A;  3S7A A;  4HOF A;  4KD7 A;  4X5J A;  3SA2 A;  4XT6 A;  4XE6 X;  1RE7 A;  3JSU A;  4ELE A;  3UM8 A;  1RA3 A;  1QZF A;  3SAI A;  1S3W A;  3FQC A;  3FQO A;  5HI6 A;  1DHJ A;  1DYI A;  3IA5 A;  3QLW A;  1DAJ A;  3FQV A;  3EEM A;  3IA4 A;  4NX7 A;  5HVB A;  4KFJ A;  1AOE A;  5DFR A;  3ZPG A;  3OAF A;  1RB3 A;  4HOE A;  1DRH A;  1KLK A;  3SH2 A;  3TQA A;  5HQZ A;  4HOG A;  4GH8 A;  3FRA X;  4KJK A;  1HFR A;  3QLX A;  3NXY A;  3F0Q X;  3RG9 A;  1DR1 A;  3HBB A;  1DF7 A;  3FRE X;  4H96 A;  5HVE A;  3F0X X;  1DR7 A;  4H98 A;  8DFR A;  4KJL A;  4ECK A;  4Q0D A;  2QK8 A;  3KFY A;  1DLR A;  2JYB A;  3SRU X;  4ELG A;  3NXT A;  3N0H A;  4QHV A;  1DYH A;  1ZDR A;  3NZ9 X;  4ELB A;  3FYV X;  1RH3 A;  1DIS A;  2CIG A;  3DGA A;  1RG7 A;  2C2T A;  4EIL A;  2W3W A;  3QLR A;  5E8Q A;  3NZC X;  1RX1 A;  3JWK A;  3DL5 A;  4KY4 A;  1AO8 A;  3JTW A;  1DHI A;  1LY4 A;  4ELF A;  1IA4 A;  3EEJ A;  3DRC A;  3Q1H A;  2W3B A;  3IRM A;  4KAK A;  1CZ3 A;  3IRO A;  5HF2 X;  3FQF A;  1CD2 A;  4KBN A;  4TU5 X;  4PTH A;  4PSY A;  3SRS X;  4HA9 A;  2LF1 A;  3IRN A;  1DG8 A;  1DR5 A;  4XEC X;  4XRB A;  2XW7 A;  3GHV A;  2D0K A;  3TQ9 A;  1OHJ A;  1VDR A;  1J3K A;  3K74 A;  2HM9 A;  5HF0 X;  7DFR A;  2ITH A;  2DHF A;  3DL6 A;  1RX7 A;  1J3J A;  3K2H A;  3EEL A;  5ECX A;  2FZH A;  3QL3 A;  3JWC A;  1PD9 A;  3R33 A;  1KMV A;  1IA1 A;  4M6J A;  2BLB A;  3JVX A;  4Q6A A;  2W9S A;  4H97 A;  4KY8 A;  4KNE A;  3DG8 A;  1JOL A;  1RF7 A;  4G95 A;  1OHK A;  3GI2 A;  4PDJ A;  4QJZ D;  5ECC A;  1RA2 A;  1BOZ A;  3ZPC A;  3F8Y A;  2H2Q A;  3SA1 A;  1DHF A;  1BZF A;  3QGT A;  3KJS A;  4P3R A;  3K47 A;  1JUV A;  4LAH X;  3TQB A;  1JOM A;  4KLX A;  3GHC A;  3NU0 A;  1S3U A;  5HT4 A;  3FL9 A;  3NRR A;  4FGG A;  1IA3 A;  1S3Y A;  2ZZA A;  1PDB A;  3LG4 A;  3KY8 A;  4QLF A;  1RX8 A;  1DRF A;  4X5G A;  5EAJ A;  3JW3 A;  3UM5 A;  1IA2 A;  1RX4 A;  3EX8 A;  3GYF A;  4I13 A;  1M79 A;  4DFR A;  1DRA A;  3CLB A;  5JG0 X;  4XT5 A;  1TDR A;  3FY8 X;  2W9T A;  5CC9 A;  3CL9 A;  3FQ0 A;  3M08 A;  5FDA A;  3F8Z A;  4X5I A;  3D84 X;  1HFP A;  1DR4 A;  3OCH A;  4QLG A;  5U27 A;  1U71 A;  4LAE X;  3FL8 A;  4I1N A;  4IXG X;  5HUI A;  3SQY X;  2G6V A;  2O7P A;  3JWM A;  4Q67 A;  1E26 A;  3NZA X;  1YHO A;  3QG2 A;  3KJR A;  5CCC A;  5JA3 A;  3FY9 X;  3VCO A;  2FZI A;  4KL9 A;  1DR2 A;  3QLS A;  4DPH A;  4XT7 A;  4M7V A;  2ANQ A;  1DRE A;  3D80 A;  3NXX A;  3QYL A;  4M2X A;  3IX9 A;  3ROA A;  4DDR A;  1LY3 A;  3I3R A;  1DR6 A;  3F0B X;  1M78 A;  3FQZ A;  1RX5 A;  2KGK A;  3SRQ X;  4FGH A;  3L3R A;  1HFQ A;  2FZJ A;  3NXO A;  4FHB A;  4HA7 A;  5DXV A;  2HXV A;  4M6K A;  4QLE A;  3EIG A;  1S3V A;  2W3A A;  2C2S A;  3QLZ A;  6DFR A;  3JWF A;  3UM6 A;  1DR3 A;  5HPB A;  4NX6 A;  3FRB X;  4IXF X;  2OIP A;  3DAU A;  3SR5 X;  1LUD A;  5HSU A;  3NTZ A;  3EEK A;  1DG5 A;  3SRW X;  1MVT A;  3SGY A;  4PTJ A;  3K45 A;  3NZB X;  2OBC A;  3E0B A;  4QJC A;  1RA8 A;  3DAT A;  3F0V X;  4G3M A;  2DRC A;  4PST A;  3FRF X;  3NZ6 X;  1RC4 A;  4KEB A;  5HQY A;  4KYA A;  3NXV A;  4P68 A;  3JW5 A;  3RO9 A;  3F91 A;  4XT4 A;  1DG7 A;  3DFR A;  4CD2 A;  3TQ8 A;  2W9H A;  1SEJ A;  4OSG A;  4ELH A;  4KJJ A;  4KM0 A;  1U70 A;  4P3Q A;  4LEK X;  3HJ3 A;  3NZD A;  5HSR A;  2GD9 A;  3QYO A;  3S9U A;  3QL0 A;  1RA9 A;  2BLC A;  1DIU A;  1RX2 A;  1DLS A;  4H95 A;  4M6L A;  2L28 A;  2BL9 A;  1DYJ A;  3FYW X;  5HT5 A;  2BLA A;  3QFX A;  3F0S X;  3S3V A;  4EJ1 A;  2D5N A;  3NXR A;  2W9G A;  4EIZ A;  4X5H A;  3KGY A;  4EIG A;  3TD8 A;  2ANO A;  2B3Z A;  2HQP A;  4QI9 A;  1RX6 A;  2W3V A;  4OR7 A;  3FS6 A;  5U26 A;  4M7U A;  1RX3 A;  1DDS A;  4DPD A;  4RGC A;  3SRR X;  1RD7 A;  2INQ A;  3QLY A;  4KM2 A;  1DRB A;  2P4G A;  1PD8 A;  3CD2 A;  4LAG X;  4PSS A;  3M09 A;  2W3M A;  1J3I A;  4G8Z X;  1U72 A;  1RA1 A;  1DDR A;  4P66 A; 
#chains in the Genus database with same CATH homology
 1AI9 A;  4XT8 A;  4DP3 A;  1RX9 A;  2CD2 A;  3FRD X;  1DYR A;  1M7A A;  1VJ3 A;  3GHW A;  3CSE A;  4X5F A;  1KMS A;  3I8A X;  1RB2 A;  1D1G A;  2AZN A;  3F0U X;  1MVS A;  4IXE D;  3INV A;  4Q0E A;  3S7A A;  4HOF A;  4KD7 A;  4X5J A;  3SA2 A;  4XT6 A;  4XE6 X;  1RE7 A;  3JSU A;  4ELE A;  3UM8 A;  1RA3 A;  1QZF A;  3SAI A;  1S3W A;  3FQC A;  3FQO A;  5HI6 A;  1DHJ A;  1DYI A;  3IA5 A;  3QLW A;  1DAJ A;  3FQV A;  3EEM A;  3IA4 A;  4NX7 A;  5HVB A;  4KFJ A;  1AOE A;  5DFR A;  3ZPG A;  3OAF A;  1RB3 A;  4HOE A;  1DRH A;  1KLK A;  3SH2 A;  3TQA A;  5HQZ A;  4HOG A;  4GH8 A;  3FRA X;  4KJK A;  1HFR A;  3QLX A;  3NXY A;  3F0Q X;  3RG9 A;  1DR1 A;  3HBB A;  1DF7 A;  3FRE X;  4H96 A;  5HVE A;  3F0X X;  1DR7 A;  4H98 A;  8DFR A;  4KJL A;  4ECK A;  4Q0D A;  2QK8 A;  3KFY A;  1DLR A;  2JYB A;  3SRU X;  4ELG A;  3NXT A;  3N0H A;  4QHV A;  1DYH A;  1ZDR A;  3NZ9 X;  4ELB A;  3FYV X;  1RH3 A;  1DIS A;  2CIG A;  3DGA A;  1RG7 A;  2C2T A;  4EIL A;  2W3W A;  3QLR A;  5E8Q A;  3NZC X;  1RX1 A;  3JWK A;  3DL5 A;  4KY4 A;  1AO8 A;  3JTW A;  1DHI A;  1LY4 A;  4ELF A;  1IA4 A;  3EEJ A;  3DRC A;  3Q1H A;  2W3B A;  3IRM A;  4KAK A;  1CZ3 A;  3IRO A;  5HF2 X;  3FQF A;  1CD2 A;  4KBN A;  4TU5 X;  4PTH A;  4PSY A;  3SRS X;  4HA9 A;  2LF1 A;  3IRN A;  1DG8 A;  1DR5 A;  4XEC X;  4XRB A;  2XW7 A;  3GHV A;  2D0K A;  3TQ9 A;  1OHJ A;  1VDR A;  1J3K A;  3K74 A;  2HM9 A;  5HF0 X;  7DFR A;  2ITH A;  2DHF A;  3DL6 A;  1RX7 A;  1J3J A;  3K2H A;  3EEL A;  5ECX A;  2FZH A;  3QL3 A;  3JWC A;  1PD9 A;  3R33 A;  1KMV A;  1IA1 A;  4M6J A;  2BLB A;  3JVX A;  4Q6A A;  2W9S A;  4H97 A;  4KY8 A;  4KNE A;  3DG8 A;  1JOL A;  1RF7 A;  4G95 A;  1OHK A;  3GI2 A;  4PDJ A;  4QJZ D;  5ECC A;  1RA2 A;  1BOZ A;  3ZPC A;  3F8Y A;  2H2Q A;  3SA1 A;  1DHF A;  1BZF A;  3QGT A;  3KJS A;  4P3R A;  3K47 A;  1JUV A;  4LAH X;  3TQB A;  1JOM A;  4KLX A;  3GHC A;  3NU0 A;  1S3U A;  5HT4 A;  3FL9 A;  3NRR A;  4FGG A;  1IA3 A;  1S3Y A;  2ZZA A;  1PDB A;  3LG4 A;  3KY8 A;  4QLF A;  1RX8 A;  1DRF A;  4X5G A;  5EAJ A;  3JW3 A;  3UM5 A;  1IA2 A;  1RX4 A;  3EX8 A;  3GYF A;  4I13 A;  1M79 A;  4DFR A;  1DRA A;  3CLB A;  5JG0 X;  4XT5 A;  1TDR A;  3FY8 X;  2W9T A;  5CC9 A;  3CL9 A;  3FQ0 A;  3M08 A;  5FDA A;  3F8Z A;  4X5I A;  3D84 X;  1HFP A;  1DR4 A;  3OCH A;  4QLG A;  5U27 A;  1U71 A;  4LAE X;  3FL8 A;  4I1N A;  4IXG X;  5HUI A;  3SQY X;  2G6V A;  2O7P A;  3JWM A;  4Q67 A;  1E26 A;  3NZA X;  1YHO A;  3QG2 A;  3KJR A;  5CCC A;  5JA3 A;  3FY9 X;  3VCO A;  2FZI A;  4KL9 A;  1DR2 A;  3QLS A;  4DPH A;  4XT7 A;  4M7V A;  2ANQ A;  1DRE A;  3D80 A;  3NXX A;  3QYL A;  4M2X A;  3IX9 A;  3ROA A;  4DDR A;  1LY3 A;  3I3R A;  1DR6 A;  3F0B X;  1M78 A;  3FQZ A;  1RX5 A;  2KGK A;  3SRQ X;  4FGH A;  3L3R A;  1HFQ A;  2FZJ A;  3NXO A;  4FHB A;  4HA7 A;  5DXV A;  2HXV A;  4M6K A;  4QLE A;  3EIG A;  1S3V A;  2W3A A;  2C2S A;  3QLZ A;  6DFR A;  3JWF A;  3UM6 A;  1DR3 A;  5HPB A;  4NX6 A;  3FRB X;  4IXF X;  2OIP A;  3DAU A;  3SR5 X;  1LUD A;  5HSU A;  3NTZ A;  3EEK A;  1DG5 A;  3SRW X;  1MVT A;  3SGY A;  4PTJ A;  3K45 A;  3NZB X;  2OBC A;  3E0B A;  4QJC A;  1RA8 A;  3DAT A;  3F0V X;  4G3M A;  2DRC A;  4PST A;  3FRF X;  3NZ6 X;  1RC4 A;  4KEB A;  5HQY A;  4KYA A;  3NXV A;  4P68 A;  3JW5 A;  3RO9 A;  3F91 A;  4XT4 A;  1DG7 A;  3DFR A;  4CD2 A;  3TQ8 A;  2W9H A;  1SEJ A;  4OSG A;  4ELH A;  4KJJ A;  4KM0 A;  1U70 A;  4P3Q A;  4LEK X;  3HJ3 A;  3NZD A;  5HSR A;  2GD9 A;  3QYO A;  3S9U A;  3QL0 A;  1RA9 A;  2BLC A;  1DIU A;  1RX2 A;  1DLS A;  4H95 A;  4M6L A;  2L28 A;  2BL9 A;  1DYJ A;  3FYW X;  5HT5 A;  2BLA A;  3QFX A;  3F0S X;  3S3V A;  4EJ1 A;  2D5N A;  3NXR A;  2W9G A;  4EIZ A;  4X5H A;  3KGY A;  4EIG A;  3TD8 A;  2ANO A;  2B3Z A;  2HQP A;  4QI9 A;  1RX6 A;  2W3V A;  4OR7 A;  3FS6 A;  5U26 A;  4M7U A;  1RX3 A;  1DDS A;  4DPD A;  4RGC A;  3SRR X;  1RD7 A;  2INQ A;  3QLY A;  4KM2 A;  1DRB A;  2P4G A;  1PD8 A;  3CD2 A;  4LAG X;  4PSS A;  3M09 A;  2W3M A;  1J3I A;  4G8Z X;  1U72 A;  1RA1 A;  1DDR A;  4P66 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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